RPL31P35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H4-K12 acetylation (GO:0043983)7.80782533
2regulation of posttranscriptional gene silencing (GO:0060147)7.38721657
3regulation of gene silencing by miRNA (GO:0060964)7.38721657
4regulation of gene silencing by RNA (GO:0060966)7.38721657
5behavioral response to nicotine (GO:0035095)7.30626651
6myoblast migration (GO:0051451)6.28728582
7negative regulation of gene silencing (GO:0060969)6.14443342
8viral transcription (GO:0019083)5.98732032
9ribosomal small subunit biogenesis (GO:0042274)5.96204791
10translational termination (GO:0006415)5.76254433
11fatty acid elongation (GO:0030497)5.37349345
12translational elongation (GO:0006414)4.95081491
13ribosomal small subunit assembly (GO:0000028)4.90620092
14intra-S DNA damage checkpoint (GO:0031573)4.90396552
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.73897140
16energy coupled proton transport, down electrochemical gradient (GO:0015985)4.68923099
17ATP synthesis coupled proton transport (GO:0015986)4.68923099
18DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.68357075
19protein targeting to ER (GO:0045047)4.65324137
20cotranslational protein targeting to membrane (GO:0006613)4.64375728
21response to pheromone (GO:0019236)4.57845611
22heart trabecula morphogenesis (GO:0061384)4.47436054
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.46271869
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.43650733
25protein localization to endoplasmic reticulum (GO:0070972)4.34486700
26DNA damage response, signal transduction resulting in transcription (GO:0042772)4.32327245
27cellular protein complex disassembly (GO:0043624)4.26847753
28viral life cycle (GO:0019058)4.21230879
29trabecula morphogenesis (GO:0061383)4.20718190
30skeletal muscle tissue regeneration (GO:0043403)4.20210152
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.18685105
32cardiovascular system development (GO:0072358)4.08754204
33mitochondrion transport along microtubule (GO:0047497)3.91507323
34establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.91507323
35signal peptide processing (GO:0006465)3.85166447
36pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.77626845
37negative regulation of striated muscle cell apoptotic process (GO:0010664)3.73418337
38nucleoside diphosphate catabolic process (GO:0009134)3.71779253
39base-excision repair, AP site formation (GO:0006285)3.69037763
40maturation of 5.8S rRNA (GO:0000460)3.68418271
41regulation of DNA damage checkpoint (GO:2000001)3.66317581
42establishment of mitochondrion localization (GO:0051654)3.64996258
43protein complex biogenesis (GO:0070271)3.63017013
44regulation of striated muscle cell apoptotic process (GO:0010662)3.57412128
45ovulation cycle (GO:0042698)3.52354735
46inner cell mass cell proliferation (GO:0001833)3.47696165
47protein complex disassembly (GO:0043241)3.47518724
48GTP biosynthetic process (GO:0006183)3.44127923
49translational initiation (GO:0006413)3.43698942
50membrane tubulation (GO:0097320)3.43325313
51positive regulation of muscle cell apoptotic process (GO:0010661)3.42501886
52cellular response to interferon-beta (GO:0035458)3.30937082
53DNA damage response, detection of DNA damage (GO:0042769)3.30237864
54macromolecular complex disassembly (GO:0032984)3.28313640
55DNA deamination (GO:0045006)3.22433590
56somite development (GO:0061053)3.22067800
57RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22067022
58tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22067022
59protein polyglutamylation (GO:0018095)3.19448326
60purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.19157638
61autophagic vacuole fusion (GO:0000046)3.17282157
62pyrimidine nucleotide catabolic process (GO:0006244)3.12733690
63phosphate ion homeostasis (GO:0055062)3.12346755
64trivalent inorganic anion homeostasis (GO:0072506)3.12346755
65ATP biosynthetic process (GO:0006754)3.11272285
66positive regulation of skeletal muscle tissue development (GO:0048643)3.10287711
67purine nucleoside triphosphate biosynthetic process (GO:0009145)3.08083036
68mitochondrial respiratory chain complex assembly (GO:0033108)3.07509516
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.06128890
70valine metabolic process (GO:0006573)3.06017062
71nuclear-transcribed mRNA catabolic process (GO:0000956)3.01056280
72mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99151761
73mitochondrial respiratory chain complex I assembly (GO:0032981)2.99151761
74NADH dehydrogenase complex assembly (GO:0010257)2.99151761
75UTP metabolic process (GO:0046051)2.95401577
76microglial cell activation (GO:0001774)2.94848445
77translation (GO:0006412)2.94792414
78UTP biosynthetic process (GO:0006228)2.92132059
79protein targeting to membrane (GO:0006612)2.91430450
80negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.90028380
81mRNA catabolic process (GO:0006402)2.87808697
82arginine catabolic process (GO:0006527)2.87142306
83replication fork processing (GO:0031297)2.86623756
84mannosylation (GO:0097502)2.85550749
85oxidative phosphorylation (GO:0006119)2.83198893
86seminiferous tubule development (GO:0072520)2.81906168
87response to xenobiotic stimulus (GO:0009410)2.81282065
88negative regulation of telomere maintenance (GO:0032205)2.77535369
89positive regulation of T cell apoptotic process (GO:0070234)2.76625801
90muscle cell fate commitment (GO:0042693)2.75336686
91regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.74848552
92cellular component biogenesis (GO:0044085)2.74798896
93positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.73796220
94macrophage chemotaxis (GO:0048246)2.73031429
95regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.72144297
96pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.71827738
97regulation of protein kinase A signaling (GO:0010738)2.70225928
98ribonucleoside triphosphate biosynthetic process (GO:0009201)2.70178478
99ribonucleoprotein complex biogenesis (GO:0022613)2.69668386
100L-fucose metabolic process (GO:0042354)2.69258948

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.61902799
2ELF1_17652178_ChIP-ChIP_JURKAT_Human6.26990852
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.12435891
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29277452
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22934696
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.19080316
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12438493
8ZNF274_21170338_ChIP-Seq_K562_Hela2.08015198
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.02159793
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.01139711
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92613435
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88974746
13EZH2_27304074_Chip-Seq_ESCs_Mouse1.87519600
14JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85085228
15ETS1_20019798_ChIP-Seq_JURKAT_Human1.84107769
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.79195985
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77292918
18CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71378272
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71350328
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.69302345
21VDR_22108803_ChIP-Seq_LS180_Human1.65531286
22REST_21632747_ChIP-Seq_MESCs_Mouse1.63569978
23TDRD3_21172665_ChIP-Seq_MCF-7_Human1.62768557
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59261900
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.58378311
26BCL6_27268052_Chip-Seq_Bcells_Human1.57183413
27YY1_22570637_ChIP-Seq_MALME-3M_Human1.56387822
28CTCF_27219007_Chip-Seq_Bcells_Human1.52934124
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51613234
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50349547
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.50279241
32MYC_18940864_ChIP-ChIP_HL60_Human1.47840411
33CTCF_20526341_ChIP-Seq_ESCs_Human1.45163335
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40986578
35E2F1_20622854_ChIP-Seq_HELA_Human1.40449697
36TP53_20018659_ChIP-ChIP_R1E_Mouse1.39961041
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37892232
38SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.37873231
39RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.36535980
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35865006
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34581642
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.33120758
43KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.31217298
44IRF1_19129219_ChIP-ChIP_H3396_Human1.29414344
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29325846
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27581908
47AR_20517297_ChIP-Seq_VCAP_Human1.25721793
48REST_18959480_ChIP-ChIP_MESCs_Mouse1.25640503
49NANOG_20526341_ChIP-Seq_ESCs_Human1.25536975
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25179384
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25179384
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24087685
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.23041422
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21290201
55STAT1_20625510_ChIP-Seq_HELA_Human1.21232037
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21102875
57PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.20446520
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.19885638
59ERA_21632823_ChIP-Seq_H3396_Human1.19472287
60SA1_27219007_Chip-Seq_Bcells_Human1.19453644
61EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.18716324
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16227179
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16143341
64TAF2_19829295_ChIP-Seq_ESCs_Human1.15160928
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13390955
66FOXH1_21741376_ChIP-Seq_ESCs_Human1.11193300
67CBP_20019798_ChIP-Seq_JUKART_Human1.10393208
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10393208
69RNF2_27304074_Chip-Seq_NSC_Mouse1.09690394
70CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09677232
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.09407843
72TP53_22573176_ChIP-Seq_HFKS_Human1.05319116
73GABP_19822575_ChIP-Seq_HepG2_Human1.04952690
74FOXH1_21741376_ChIP-Seq_EPCs_Human1.02195495
75SPI1_20517297_ChIP-Seq_HL60_Human1.01654812
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.01356835
77SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00416297
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.00016150
79MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99714376
80OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99383363
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99370836
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98272002
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.98272002
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97977131
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97866474
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97841159
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97357739
88SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.97181747
89NOTCH1_21737748_ChIP-Seq_TLL_Human0.97134938
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96450567
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95756836
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95639250
93TP63_19390658_ChIP-ChIP_HaCaT_Human0.93165506
94VDR_23849224_ChIP-Seq_CD4+_Human0.92269031
95CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91701818
96RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91124789
97P68_20966046_ChIP-Seq_HELA_Human0.90836450
98SOX2_21211035_ChIP-Seq_LN229_Human0.90084005
99KLF4_19829295_ChIP-Seq_ESCs_Human0.89958743
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89179747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.73652245
2MP0003787_abnormal_imprinting4.73393434
3MP0002638_abnormal_pupillary_reflex3.75054873
4MP0003646_muscle_fatigue3.49372079
5MP0008877_abnormal_DNA_methylation3.31921229
6MP0001188_hyperpigmentation2.68460439
7MP0002234_abnormal_pharynx_morphology2.58298481
8MP0003121_genomic_imprinting2.51435545
9MP0003567_abnormal_fetal_cardiomyocyte2.28478093
10MP0003315_abnormal_perineum_morphology2.18849838
11MP0002138_abnormal_hepatobiliary_system2.13326454
12MP0006292_abnormal_olfactory_placode2.09723143
13MP0004185_abnormal_adipocyte_glucose2.08727671
14MP0004142_abnormal_muscle_tone2.06176099
15MP0003122_maternal_imprinting1.93831228
16MP0006082_CNS_inflammation1.86877523
17MP0001919_abnormal_reproductive_system1.84759757
18MP0004883_abnormal_blood_vessel1.83874378
19MP0002837_dystrophic_cardiac_calcinosis1.80425015
20MP0005646_abnormal_pituitary_gland1.79726916
21MP0005389_reproductive_system_phenotype1.77975178
22MP0000750_abnormal_muscle_regeneration1.75398053
23MP0005671_abnormal_response_to1.68617454
24MP0004885_abnormal_endolymph1.66940300
25MP0002653_abnormal_ependyma_morphology1.66814938
26MP0004145_abnormal_muscle_electrophysio1.63936803
27MP0008789_abnormal_olfactory_epithelium1.60355965
28MP0002102_abnormal_ear_morphology1.60098267
29MP0005551_abnormal_eye_electrophysiolog1.59345317
30MP0000613_abnormal_salivary_gland1.54917753
31MP0000049_abnormal_middle_ear1.48933358
32MP0002160_abnormal_reproductive_system1.47631776
33MP0005499_abnormal_olfactory_system1.46129629
34MP0005394_taste/olfaction_phenotype1.46129629
35MP0000685_abnormal_immune_system1.43868420
36MP0006072_abnormal_retinal_apoptosis1.39577564
37MP0002163_abnormal_gland_morphology1.31647161
38MP0003183_abnormal_peptide_metabolism1.30217321
39MP0005645_abnormal_hypothalamus_physiol1.28990362
40MP0005195_abnormal_posterior_eye1.26636990
41MP0004019_abnormal_vitamin_homeostasis1.24009436
42MP0002272_abnormal_nervous_system1.23875282
43MP0004858_abnormal_nervous_system1.23705892
44MP0001968_abnormal_touch/_nociception1.15803493
45MP0008260_abnormal_autophagy1.15181469
46MP0002736_abnormal_nociception_after1.09949614
47MP0004043_abnormal_pH_regulation1.09317492
48MP0000569_abnormal_digit_pigmentation1.07818551
49MP0008872_abnormal_physiological_respon1.06856645
50MP0002733_abnormal_thermal_nociception1.06804973
51MP0003045_fibrosis1.05098300
52MP0006276_abnormal_autonomic_nervous1.03989001
53MP0003123_paternal_imprinting1.02805533
54MP0009333_abnormal_splenocyte_physiolog1.00574844
55MP0008875_abnormal_xenobiotic_pharmacok0.99750717
56MP0005670_abnormal_white_adipose0.94245431
57MP0001348_abnormal_lacrimal_gland0.93028838
58MP0001970_abnormal_pain_threshold0.91358937
59MP0001485_abnormal_pinna_reflex0.89268202
60MP0009745_abnormal_behavioral_response0.88511886
61MP0000778_abnormal_nervous_system0.87510086
62MP0002210_abnormal_sex_determination0.84962232
63MP0001293_anophthalmia0.84747995
64MP0002557_abnormal_social/conspecific_i0.84249823
65MP0001145_abnormal_male_reproductive0.83728202
66MP0003186_abnormal_redox_activity0.82518867
67MP0001440_abnormal_grooming_behavior0.82181718
68MP0003136_yellow_coat_color0.81354725
69MP0000026_abnormal_inner_ear0.81046088
70MP0002822_catalepsy0.79608666
71MP0004742_abnormal_vestibular_system0.78466281
72MP0010030_abnormal_orbit_morphology0.77621962
73MP0005197_abnormal_uvea_morphology0.77293083
74MP0001986_abnormal_taste_sensitivity0.74596230
75MP0004130_abnormal_muscle_cell0.73321850
76MP0003880_abnormal_central_pattern0.73033300
77MP0005379_endocrine/exocrine_gland_phen0.70749612
78MP0002229_neurodegeneration0.70726924
79MP0005166_decreased_susceptibility_to0.70595585
80MP0002184_abnormal_innervation0.70350185
81MP0001486_abnormal_startle_reflex0.70096322
82MP0004133_heterotaxia0.69854808
83MP0009046_muscle_twitch0.69580106
84MP0000653_abnormal_sex_gland0.68841418
85MP0000631_abnormal_neuroendocrine_gland0.68083160
86MP0009250_abnormal_appendicular_skeleto0.67351518
87MP0005164_abnormal_response_to0.66882908
88MP0003878_abnormal_ear_physiology0.66826355
89MP0005377_hearing/vestibular/ear_phenot0.66826355
90MP0002876_abnormal_thyroid_physiology0.65309966
91MP0000230_abnormal_systemic_arterial0.65299399
92MP0002249_abnormal_larynx_morphology0.65265983
93MP0002938_white_spotting0.64913210
94MP0003119_abnormal_digestive_system0.64047212
95MP0002734_abnormal_mechanical_nocicepti0.63880766
96MP0001663_abnormal_digestive_system0.63807492
97MP0003936_abnormal_reproductive_system0.62887383
98MP0002277_abnormal_respiratory_mucosa0.62696823
99MP0002752_abnormal_somatic_nervous0.60729051
100MP0003942_abnormal_urinary_system0.59412603

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)5.55773473
2Abnormal rod and cone electroretinograms (HP:0008323)5.27102042
3Deep palmar crease (HP:0006191)4.38437021
4Prostate neoplasm (HP:0100787)4.16574290
5Pendular nystagmus (HP:0012043)4.09657045
6Congenital stationary night blindness (HP:0007642)3.99415396
7Asplenia (HP:0001746)3.92744749
8Pachygyria (HP:0001302)3.81326318
9Oligomenorrhea (HP:0000876)3.80498727
10Aplasia/Hypoplasia of the spleen (HP:0010451)3.75372441
11Self-mutilation (HP:0000742)3.60304493
12Congenital malformation of the right heart (HP:0011723)3.44294245
13Double outlet right ventricle (HP:0001719)3.44294245
14Type II lissencephaly (HP:0007260)3.31482386
15Acute necrotizing encephalopathy (HP:0006965)3.23965231
16Increased corneal curvature (HP:0100692)3.20460667
17Keratoconus (HP:0000563)3.20460667
18Decreased central vision (HP:0007663)2.96491247
19Severe visual impairment (HP:0001141)2.93567473
20Mitochondrial inheritance (HP:0001427)2.84151353
21Dynein arm defect of respiratory motile cilia (HP:0012255)2.83695099
22Absent/shortened dynein arms (HP:0200106)2.83695099
23Abnormal mitochondria in muscle tissue (HP:0008316)2.78713520
24Pancreatic fibrosis (HP:0100732)2.74353169
25Sclerocornea (HP:0000647)2.73492483
26Attenuation of retinal blood vessels (HP:0007843)2.71735864
27Decreased electroretinogram (ERG) amplitude (HP:0000654)2.66755187
28Progressive macrocephaly (HP:0004481)2.60949187
29Lissencephaly (HP:0001339)2.60115867
30Reticulocytopenia (HP:0001896)2.55053703
31Acute encephalopathy (HP:0006846)2.50624687
32Rib fusion (HP:0000902)2.50557540
33Renal cortical cysts (HP:0000803)2.43805465
34Abnormality of cells of the erythroid lineage (HP:0012130)2.43553687
35Pallor (HP:0000980)2.43431756
36True hermaphroditism (HP:0010459)2.42525148
37Colon cancer (HP:0003003)2.42138473
38Truncus arteriosus (HP:0001660)2.37451515
39Abnormality of the aortic arch (HP:0012303)2.37083485
40Optic disc pallor (HP:0000543)2.36011433
41Agitation (HP:0000713)2.34052526
42Increased CSF lactate (HP:0002490)2.33752334
43Bulbous nose (HP:0000414)2.31742188
44Anencephaly (HP:0002323)2.31353944
45Pancreatic cysts (HP:0001737)2.22628973
46Macrocytic anemia (HP:0001972)2.21500327
47Congenital, generalized hypertrichosis (HP:0004540)2.20873644
48Poor suck (HP:0002033)2.17423143
49Progressive microcephaly (HP:0000253)2.15706395
50Scotoma (HP:0000575)2.15110531
51Acanthocytosis (HP:0001927)2.12431498
52Abnormality of the prostate (HP:0008775)2.12336144
53Abnormality of the antihelix (HP:0009738)2.09180767
54Cutaneous melanoma (HP:0012056)2.09022540
55Optic nerve coloboma (HP:0000588)2.09014947
56Maternal diabetes (HP:0009800)2.08997785
57Absent thumb (HP:0009777)2.03497555
58Dyskinesia (HP:0100660)2.01714763
59Cortical dysplasia (HP:0002539)2.00166014
60Molar tooth sign on MRI (HP:0002419)1.99755652
61Abnormality of midbrain morphology (HP:0002418)1.99755652
62Poor head control (HP:0002421)1.99362285
63Abnormal respiratory epithelium morphology (HP:0012253)1.98840470
64Abnormal respiratory motile cilium morphology (HP:0005938)1.98840470
65Elevated erythrocyte sedimentation rate (HP:0003565)1.96667006
66Lipid accumulation in hepatocytes (HP:0006561)1.94467920
67Abnormal ciliary motility (HP:0012262)1.94196859
68Stenosis of the external auditory canal (HP:0000402)1.93728586
69Cystic liver disease (HP:0006706)1.91335410
70Cerebral hypomyelination (HP:0006808)1.90737088
71Decreased muscle mass (HP:0003199)1.89176101
72Increased hepatocellular lipid droplets (HP:0006565)1.88952749
73Disinhibition (HP:0000734)1.84455691
74Nephronophthisis (HP:0000090)1.83330648
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83040694
76Hepatocellular necrosis (HP:0001404)1.82033079
77Alveolar cell carcinoma (HP:0006519)1.81250670
78Erythroderma (HP:0001019)1.80022209
79Visual hallucinations (HP:0002367)1.79924040
80Palpebral edema (HP:0100540)1.77908415
81Male pseudohermaphroditism (HP:0000037)1.77667267
82Polyphagia (HP:0002591)1.76904530
83Villous atrophy (HP:0011473)1.76274757
84Abnormality of small intestinal villus morphology (HP:0011472)1.76274757
85Submucous cleft hard palate (HP:0000176)1.75541187
86Epidermoid cyst (HP:0200040)1.75040251
87Bony spicule pigmentary retinopathy (HP:0007737)1.74776670
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.74546727
89Muscle fiber atrophy (HP:0100295)1.73251475
90Renal Fanconi syndrome (HP:0001994)1.72781235
91Supernumerary spleens (HP:0009799)1.72069373
92Abnormality of hair growth rate (HP:0011363)1.71644824
93Slow-growing hair (HP:0002217)1.71644824
94Cerebral edema (HP:0002181)1.69114907
95Abnormality of DNA repair (HP:0003254)1.69053715
96Type 2 muscle fiber atrophy (HP:0003554)1.68737183
97Abnormality of the renal cortex (HP:0011035)1.68106595
98Abnormal ventriculo-arterial connection (HP:0011563)1.67978563
99Transposition of the great arteries (HP:0001669)1.67978563
100Abnormal connection of the cardiac segments (HP:0011545)1.67978563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF18.04678836
2IRAK45.23774689
3AKT35.05808081
4VRK24.23258442
5SMG12.96258433
6NUAK12.94469673
7BRAF2.37269001
8MAP3K112.12831326
9NME21.83349480
10DYRK21.80729419
11PRKD31.70650361
12ILK1.68821223
13MARK31.66487323
14KSR11.62485038
15PIK3CG1.55560023
16WNK31.43281950
17WNK41.43263137
18MAPKAPK51.36366582
19VRK11.23958679
20DAPK11.22827045
21ACVR1B1.18639808
22LRRK21.14859585
23PRKCI1.10640594
24TLK11.08602572
25FRK1.07911244
26GRK51.05178372
27SGK4941.02645216
28SGK2231.02645216
29HIPK21.00152812
30GRK10.98410193
31SGK20.98010979
32STK110.96920015
33ADRBK20.95071749
34GRK60.89628100
35RIPK40.86752177
36DAPK30.82858045
37PTK20.82844756
38STK390.74003968
39CSNK1G20.72193226
40STK160.71645895
41BCKDK0.70510963
42ERN10.69878766
43ABL20.68608237
44PRKCZ0.68053493
45BMPR1B0.66599964
46PLK20.65624205
47MAPK130.63207540
48PRKCG0.62026876
49PHKG10.60246374
50PHKG20.60246374
51MAP4K10.57610471
52TNIK0.56350223
53WEE10.56159304
54SGK30.54065650
55NTRK20.52484640
56CDC70.52232435
57PINK10.49737446
58INSRR0.47465368
59CSNK1G30.47291801
60CDK90.47186387
61PIK3CA0.46871063
62MAP4K20.45801971
63TIE10.45427430
64PTK60.45230593
65PAK30.44675823
66PRKACA0.43444656
67EPHB20.43246261
68CHEK10.41917395
69AURKA0.41495055
70KIT0.40995218
71EIF2AK20.40963189
72MAPKAPK30.40830967
73CSNK2A20.40743118
74CAMK10.39853383
75MAP2K60.37853994
76CSNK1A1L0.36943481
77CDK190.36529410
78CSNK1G10.36241162
79CAMKK20.33345820
80PLK40.32893006
81DAPK20.32774818
82CAMK40.32526899
83CDK70.31558937
84ERBB30.31117531
85BRSK10.30890779
86RPS6KA60.29924012
87PIM10.29410547
88SYK0.28755629
89AURKB0.27435180
90CSNK2A10.27434350
91IKBKB0.27182474
92PKN10.26819839
93OBSCN0.24697185
94IRAK10.24546853
95PRKCQ0.24073443
96CSNK1E0.21972786
97MAPK110.20720678
98DYRK1A0.19807194
99TXK0.19622842
100PLK30.19481521

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.20916112
2Oxidative phosphorylation_Homo sapiens_hsa001903.67744402
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.02809460
4Sulfur relay system_Homo sapiens_hsa041222.87786179
5Parkinsons disease_Homo sapiens_hsa050122.73721755
6Fatty acid elongation_Homo sapiens_hsa000622.70540910
7Alzheimers disease_Homo sapiens_hsa050102.24090857
8Phototransduction_Homo sapiens_hsa047442.21818648
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09379505
10Cardiac muscle contraction_Homo sapiens_hsa042602.02867912
11Huntingtons disease_Homo sapiens_hsa050162.00435827
12Homologous recombination_Homo sapiens_hsa034401.95926740
13Linoleic acid metabolism_Homo sapiens_hsa005911.95200709
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.86728387
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65068401
16RNA polymerase_Homo sapiens_hsa030201.60721661
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50842003
18Nitrogen metabolism_Homo sapiens_hsa009101.50822404
19RNA degradation_Homo sapiens_hsa030181.50455967
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.47046082
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40545921
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38809746
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36736513
24Fanconi anemia pathway_Homo sapiens_hsa034601.31329740
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29667912
26Asthma_Homo sapiens_hsa053101.27963169
27Nicotine addiction_Homo sapiens_hsa050331.26648506
28Olfactory transduction_Homo sapiens_hsa047401.18227126
29Graft-versus-host disease_Homo sapiens_hsa053321.18177570
30Pyrimidine metabolism_Homo sapiens_hsa002401.12979413
31Primary immunodeficiency_Homo sapiens_hsa053401.08693556
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07364874
33Caffeine metabolism_Homo sapiens_hsa002321.07050386
34Sulfur metabolism_Homo sapiens_hsa009201.05371272
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.05086955
36Regulation of autophagy_Homo sapiens_hsa041401.04658925
37Proteasome_Homo sapiens_hsa030500.97567310
38Basal transcription factors_Homo sapiens_hsa030220.95724955
39Steroid biosynthesis_Homo sapiens_hsa001000.92384194
40Autoimmune thyroid disease_Homo sapiens_hsa053200.87929535
41Arachidonic acid metabolism_Homo sapiens_hsa005900.86355269
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85829356
43Base excision repair_Homo sapiens_hsa034100.83932733
44Melanoma_Homo sapiens_hsa052180.83932678
45Allograft rejection_Homo sapiens_hsa053300.83900716
46Type I diabetes mellitus_Homo sapiens_hsa049400.83889038
47Basal cell carcinoma_Homo sapiens_hsa052170.82312302
48Peroxisome_Homo sapiens_hsa041460.79333367
49Vitamin B6 metabolism_Homo sapiens_hsa007500.77510381
50Notch signaling pathway_Homo sapiens_hsa043300.76896079
51Protein export_Homo sapiens_hsa030600.73719283
52Insulin secretion_Homo sapiens_hsa049110.71158220
53Fat digestion and absorption_Homo sapiens_hsa049750.71011144
54Thyroid cancer_Homo sapiens_hsa052160.68831529
55Nucleotide excision repair_Homo sapiens_hsa034200.67294202
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66244270
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65703208
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65617720
59ABC transporters_Homo sapiens_hsa020100.65251795
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64241744
61Ether lipid metabolism_Homo sapiens_hsa005650.63453624
62Chemical carcinogenesis_Homo sapiens_hsa052040.62571439
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60360049
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59534467
65Hedgehog signaling pathway_Homo sapiens_hsa043400.58999409
66Purine metabolism_Homo sapiens_hsa002300.58772902
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57678181
68Salivary secretion_Homo sapiens_hsa049700.56128702
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.55896429
70Butanoate metabolism_Homo sapiens_hsa006500.55452548
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53048352
72Bladder cancer_Homo sapiens_hsa052190.52519704
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51141422
74Selenocompound metabolism_Homo sapiens_hsa004500.50885691
75Retinol metabolism_Homo sapiens_hsa008300.50693786
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49232673
77Morphine addiction_Homo sapiens_hsa050320.48809581
78Arginine and proline metabolism_Homo sapiens_hsa003300.48463013
79Metabolic pathways_Homo sapiens_hsa011000.48307283
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45425042
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.44785609
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42955736
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.41003167
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39560882
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.38423346
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38130408
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38035236
88Ovarian steroidogenesis_Homo sapiens_hsa049130.37574415
89beta-Alanine metabolism_Homo sapiens_hsa004100.36802304
90Mismatch repair_Homo sapiens_hsa034300.36748249
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36531921
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35829531
93DNA replication_Homo sapiens_hsa030300.33899821
94Mineral absorption_Homo sapiens_hsa049780.31798553
95Serotonergic synapse_Homo sapiens_hsa047260.31137579
96Pertussis_Homo sapiens_hsa051330.27204190
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26359890
98Non-small cell lung cancer_Homo sapiens_hsa052230.25955966
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25164381
100Axon guidance_Homo sapiens_hsa043600.24846663

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