RPL31P41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)7.47317362
2maturation of SSU-rRNA (GO:0030490)7.24278179
3viral transcription (GO:0019083)7.03234558
4ribosomal small subunit assembly (GO:0000028)6.87326436
5translational termination (GO:0006415)6.63401095
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.61976977
7cotranslational protein targeting to membrane (GO:0006613)5.56551480
8translational elongation (GO:0006414)5.54310828
9protein targeting to ER (GO:0045047)5.48137153
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.25420740
11protein localization to endoplasmic reticulum (GO:0070972)5.11135436
12viral life cycle (GO:0019058)5.02910931
13water-soluble vitamin biosynthetic process (GO:0042364)5.02265629
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.98965779
15cellular protein complex disassembly (GO:0043624)4.95040369
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.66439850
17behavioral response to nicotine (GO:0035095)4.44210557
18protein complex disassembly (GO:0043241)4.34582340
19nonmotile primary cilium assembly (GO:0035058)4.20990867
20DNA methylation involved in gamete generation (GO:0043046)4.12361906
21macromolecular complex disassembly (GO:0032984)4.12361058
22piRNA metabolic process (GO:0034587)4.08184422
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.91048980
24mitochondrial respiratory chain complex I assembly (GO:0032981)3.91048980
25NADH dehydrogenase complex assembly (GO:0010257)3.91048980
26cell wall macromolecule catabolic process (GO:0016998)3.88914710
27protein targeting to membrane (GO:0006612)3.88317190
28translational initiation (GO:0006413)3.87071885
29regulation of cilium movement (GO:0003352)3.84233796
30ribosomal large subunit biogenesis (GO:0042273)3.82360740
31kynurenine metabolic process (GO:0070189)3.77275911
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.75382978
33ATP synthesis coupled proton transport (GO:0015986)3.75382978
34nuclear-transcribed mRNA catabolic process (GO:0000956)3.75119236
35cell proliferation in forebrain (GO:0021846)3.70468587
36response to gravity (GO:0009629)3.61708370
37positive regulation of respiratory burst (GO:0060267)3.58498494
38tryptophan catabolic process (GO:0006569)3.58266284
39indole-containing compound catabolic process (GO:0042436)3.58266284
40indolalkylamine catabolic process (GO:0046218)3.58266284
41protein complex biogenesis (GO:0070271)3.56630063
42mRNA catabolic process (GO:0006402)3.51964748
43negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.47688307
44protein neddylation (GO:0045116)3.41179203
45synapsis (GO:0007129)3.39478257
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.37523814
47nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37163069
48head development (GO:0060322)3.35514558
49dentate gyrus development (GO:0021542)3.35064897
50auditory receptor cell differentiation (GO:0042491)3.34477958
51cardiovascular system development (GO:0072358)3.30843805
52chaperone-mediated protein transport (GO:0072321)3.25972743
53positive regulation of T cell apoptotic process (GO:0070234)3.25475462
54cell wall macromolecule metabolic process (GO:0044036)3.24889494
55epithelial cilium movement (GO:0003351)3.21207914
56somite development (GO:0061053)3.19366515
57translation (GO:0006412)3.17249555
58myoblast migration (GO:0051451)3.16988888
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.12310395
60viral protein processing (GO:0019082)3.12044024
61negative regulation of appetite (GO:0032099)3.10826059
62negative regulation of response to food (GO:0032096)3.10826059
63protein K6-linked ubiquitination (GO:0085020)3.09606391
64regulation of microtubule-based movement (GO:0060632)3.06767006
65mitochondrial respiratory chain complex assembly (GO:0033108)3.06128547
66pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.05752715
67RNA catabolic process (GO:0006401)3.04028651
68RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.02248071
69tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.02248071
70spinal cord association neuron differentiation (GO:0021527)3.02232836
71retinal rod cell development (GO:0046548)3.02158341
72central nervous system myelination (GO:0022010)2.98036705
73axon ensheathment in central nervous system (GO:0032291)2.98036705
74mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96649205
75cellular component biogenesis (GO:0044085)2.96353396
76kinetochore assembly (GO:0051382)2.95827585
77resolution of meiotic recombination intermediates (GO:0000712)2.95621776
78ribonucleoprotein complex biogenesis (GO:0022613)2.92209967
79tryptophan metabolic process (GO:0006568)2.91246615
80neuronal stem cell maintenance (GO:0097150)2.90879286
81kinetochore organization (GO:0051383)2.89763138
82ncRNA 3-end processing (GO:0043628)2.86746212
83sulfate transmembrane transport (GO:1902358)2.85973438
84neuron fate determination (GO:0048664)2.85806979
85cilium movement (GO:0003341)2.83645298
86brain morphogenesis (GO:0048854)2.82354712
87negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.78106484
88genetic imprinting (GO:0071514)2.75153855
89establishment of protein localization to mitochondrial membrane (GO:0090151)2.70938526
90electron transport chain (GO:0022900)2.70812962
91cellular biogenic amine catabolic process (GO:0042402)2.69702550
92amine catabolic process (GO:0009310)2.69702550
93positive regulation of lymphocyte apoptotic process (GO:0070230)2.69049100
94respiratory electron transport chain (GO:0022904)2.67606398
95establishment of protein localization to membrane (GO:0090150)2.64970087
96indolalkylamine metabolic process (GO:0006586)2.62048470
97protein targeting (GO:0006605)2.60461523
98substrate-independent telencephalic tangential migration (GO:0021826)2.60438857
99substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.60438857
100regulation of DNA endoreduplication (GO:0032875)2.58652674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.62254873
2VDR_22108803_ChIP-Seq_LS180_Human3.34880465
3IRF1_19129219_ChIP-ChIP_H3396_Human2.70708137
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.66810906
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.65851126
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.51181233
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25521289
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25517103
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12425898
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.04170875
11ZNF274_21170338_ChIP-Seq_K562_Hela1.92951189
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92516212
13EST1_17652178_ChIP-ChIP_JURKAT_Human1.87144079
14JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86693549
15GATA1_26923725_Chip-Seq_HPCs_Mouse1.85953004
16BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84967878
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.82752745
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81114375
19RNF2_27304074_Chip-Seq_NSC_Mouse1.73423276
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.71450481
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70569773
22REST_21632747_ChIP-Seq_MESCs_Mouse1.63702952
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.62684746
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.62567267
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62239111
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51898618
27NANOG_20526341_ChIP-Seq_ESCs_Human1.45560414
28ERA_21632823_ChIP-Seq_H3396_Human1.44752149
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44027773
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42398871
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.40914966
32SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.39518691
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38201003
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37837096
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35219827
36MYC_18940864_ChIP-ChIP_HL60_Human1.35080821
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.34337549
38TAF2_19829295_ChIP-Seq_ESCs_Human1.33526115
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.33154702
40FUS_26573619_Chip-Seq_HEK293_Human1.31638439
41FOXH1_21741376_ChIP-Seq_EPCs_Human1.29081557
42TTF2_22483619_ChIP-Seq_HELA_Human1.29073912
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28595230
44GATA3_21878914_ChIP-Seq_MCF-7_Human1.23142029
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22262953
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21495501
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20451248
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.19743688
49TP53_20018659_ChIP-ChIP_R1E_Mouse1.18524709
50CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16292820
51XRN2_22483619_ChIP-Seq_HELA_Human1.15920038
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15428017
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14798424
54FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12927641
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11404541
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11404541
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11309259
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11231673
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10816473
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09212591
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08271948
62OCT4_20526341_ChIP-Seq_ESCs_Human1.07686870
63FOXH1_21741376_ChIP-Seq_ESCs_Human1.07086109
64FOXP3_21729870_ChIP-Seq_TREG_Human1.06534990
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05276515
66EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03727933
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03533598
68IGF1R_20145208_ChIP-Seq_DFB_Human1.03129213
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02237626
70ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02225265
71TP53_22573176_ChIP-Seq_HFKS_Human1.02171783
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01712240
73CTCF_27219007_Chip-Seq_Bcells_Human1.01309158
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.01289333
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00641667
76ELK1_19687146_ChIP-ChIP_HELA_Human1.00498948
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99533602
78NCOR_22424771_ChIP-Seq_293T_Human0.99038490
79BCL6_27268052_Chip-Seq_Bcells_Human0.97835786
80BCAT_22108803_ChIP-Seq_LS180_Human0.96345260
81GABP_19822575_ChIP-Seq_HepG2_Human0.95507532
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95367823
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95173454
84GATA3_21867929_ChIP-Seq_TH1_Mouse0.93803014
85TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92758986
86CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92385721
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92232243
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92155952
89EWS_26573619_Chip-Seq_HEK293_Human0.90957823
90E2F1_20622854_ChIP-Seq_HELA_Human0.90113353
91P68_20966046_ChIP-Seq_HELA_Human0.89434613
92P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89287229
93SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87367937
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87000328
95VDR_23849224_ChIP-Seq_CD4+_Human0.85877222
96OCT4_19829295_ChIP-Seq_ESCs_Human0.85823644
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85784609
98HOXB7_26014856_ChIP-Seq_BT474_Human0.85702242
99RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85586763
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85361365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.58610082
2MP0006292_abnormal_olfactory_placode4.54055208
3MP0002653_abnormal_ependyma_morphology3.18952196
4MP0003787_abnormal_imprinting3.04533017
5MP0003122_maternal_imprinting3.04237305
6MP0008789_abnormal_olfactory_epithelium2.97003427
7MP0008877_abnormal_DNA_methylation2.65748213
8MP0005394_taste/olfaction_phenotype2.53953759
9MP0005499_abnormal_olfactory_system2.53953759
10MP0001485_abnormal_pinna_reflex2.34457977
11MP0002163_abnormal_gland_morphology2.21713878
12MP0003121_genomic_imprinting2.16649195
13MP0003646_muscle_fatigue2.11976524
14MP0001293_anophthalmia2.07797291
15MP0003123_paternal_imprinting1.96030188
16MP0002102_abnormal_ear_morphology1.86743637
17MP0002234_abnormal_pharynx_morphology1.85800522
18MP0003878_abnormal_ear_physiology1.85327589
19MP0005377_hearing/vestibular/ear_phenot1.85327589
20MP0006276_abnormal_autonomic_nervous1.84080031
21MP0004145_abnormal_muscle_electrophysio1.84005971
22MP0001984_abnormal_olfaction1.81094034
23MP0002938_white_spotting1.79653685
24MP0004885_abnormal_endolymph1.77866368
25MP0001968_abnormal_touch/_nociception1.75600476
26MP0000049_abnormal_middle_ear1.72322080
27MP0000631_abnormal_neuroendocrine_gland1.67102880
28MP0005551_abnormal_eye_electrophysiolog1.59755179
29MP0000778_abnormal_nervous_system1.56986525
30MP0004142_abnormal_muscle_tone1.55587177
31MP0002160_abnormal_reproductive_system1.46849510
32MP0005084_abnormal_gallbladder_morpholo1.44100281
33MP0000955_abnormal_spinal_cord1.43858156
34MP0001440_abnormal_grooming_behavior1.37268503
35MP0005195_abnormal_posterior_eye1.35396089
36MP0004742_abnormal_vestibular_system1.34199448
37MP0002837_dystrophic_cardiac_calcinosis1.33941220
38MP0002736_abnormal_nociception_after1.33807870
39MP0002557_abnormal_social/conspecific_i1.31952152
40MP0001970_abnormal_pain_threshold1.30024246
41MP0004133_heterotaxia1.29143933
42MP0002733_abnormal_thermal_nociception1.29094827
43MP0006072_abnormal_retinal_apoptosis1.28851147
44MP0002734_abnormal_mechanical_nocicepti1.27181291
45MP0001986_abnormal_taste_sensitivity1.20967648
46MP0001905_abnormal_dopamine_level1.20449470
47MP0009745_abnormal_behavioral_response1.18707445
48MP0002272_abnormal_nervous_system1.18427036
49MP0002063_abnormal_learning/memory/cond1.17853909
50MP0005389_reproductive_system_phenotype1.15916080
51MP0005645_abnormal_hypothalamus_physiol1.14750059
52MP0005174_abnormal_tail_pigmentation1.14433714
53MP0002184_abnormal_innervation1.12009310
54MP0003879_abnormal_hair_cell1.11897963
55MP0002095_abnormal_skin_pigmentation1.11454944
56MP0002752_abnormal_somatic_nervous1.10740874
57MP0002572_abnormal_emotion/affect_behav1.10065422
58MP0003938_abnormal_ear_development1.09944844
59MP0000026_abnormal_inner_ear1.09766450
60MP0001486_abnormal_startle_reflex1.09587258
61MP0005379_endocrine/exocrine_gland_phen1.05547510
62MP0001963_abnormal_hearing_physiology1.05145911
63MP0003119_abnormal_digestive_system1.02973371
64MP0003011_delayed_dark_adaptation0.99686448
65MP0008775_abnormal_heart_ventricle0.98636829
66MP0005423_abnormal_somatic_nervous0.98585432
67MP0003635_abnormal_synaptic_transmissio0.98478187
68MP0005448_abnormal_energy_balance0.98105695
69MP0004859_abnormal_synaptic_plasticity0.96940544
70MP0003195_calcinosis0.95191406
71MP0002152_abnormal_brain_morphology0.94765407
72MP0003937_abnormal_limbs/digits/tail_de0.93991962
73MP0002233_abnormal_nose_morphology0.93882012
74MP0001529_abnormal_vocalization0.92563882
75MP0002882_abnormal_neuron_morphology0.91876706
76MP0004043_abnormal_pH_regulation0.90231063
77MP0008872_abnormal_physiological_respon0.85783507
78MP0003942_abnormal_urinary_system0.85690759
79MP0002876_abnormal_thyroid_physiology0.85664228
80MP0001502_abnormal_circadian_rhythm0.85296442
81MP0001286_abnormal_eye_development0.83560205
82MP0002210_abnormal_sex_determination0.81224796
83MP0003880_abnormal_central_pattern0.79095440
84MP0002638_abnormal_pupillary_reflex0.78056740
85MP0002067_abnormal_sensory_capabilities0.78051549
86MP0002229_neurodegeneration0.76559409
87MP0003136_yellow_coat_color0.76309350
88MP0003861_abnormal_nervous_system0.76130533
89MP0003698_abnormal_male_reproductive0.75916202
90MP0003283_abnormal_digestive_organ0.75161646
91MP0002064_seizures0.74342277
92MP0001944_abnormal_pancreas_morphology0.73016167
93MP0005253_abnormal_eye_physiology0.70740088
94MP0009046_muscle_twitch0.70361650
95MP0000427_abnormal_hair_cycle0.69734762
96MP0002928_abnormal_bile_duct0.68210582
97MP0003186_abnormal_redox_activity0.67711264
98MP0002735_abnormal_chemical_nociception0.66706809
99MP0005220_abnormal_exocrine_pancreas0.66609385
100MP0000653_abnormal_sex_gland0.64158431

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.43656778
2Pancreatic fibrosis (HP:0100732)4.30484052
3Molar tooth sign on MRI (HP:0002419)4.20044477
4Abnormality of midbrain morphology (HP:0002418)4.20044477
5Medial flaring of the eyebrow (HP:0010747)3.92936361
6Abnormal hair whorl (HP:0010721)3.86864656
7Abnormality of cells of the erythroid lineage (HP:0012130)3.76144855
8Stenosis of the external auditory canal (HP:0000402)3.57258434
9Macrocytic anemia (HP:0001972)3.49835688
10Acute necrotizing encephalopathy (HP:0006965)3.49471586
11Type II lissencephaly (HP:0007260)3.49294742
12Nephronophthisis (HP:0000090)3.37193792
13Acute encephalopathy (HP:0006846)3.30532397
14Gait imbalance (HP:0002141)3.28451476
15Colon cancer (HP:0003003)3.25490963
16Asplenia (HP:0001746)3.13358289
17Congenital primary aphakia (HP:0007707)3.09252167
18Hyperglycinemia (HP:0002154)3.08737808
19Aplasia/Hypoplasia of the spleen (HP:0010451)3.03976818
20Pancreatic cysts (HP:0001737)3.03658380
21Abnormal mitochondria in muscle tissue (HP:0008316)3.00193220
22True hermaphroditism (HP:0010459)2.98941105
23Cerebellar dysplasia (HP:0007033)2.97944610
24Supernumerary spleens (HP:0009799)2.96328924
25Progressive macrocephaly (HP:0004481)2.96129897
26Pallor (HP:0000980)2.93152253
27Partial duplication of thumb phalanx (HP:0009944)2.91246596
28Nephrogenic diabetes insipidus (HP:0009806)2.88502679
29Mitochondrial inheritance (HP:0001427)2.82987832
30Papilledema (HP:0001085)2.75166497
31Abnormal hemoglobin (HP:0011902)2.61746757
32Absent thumb (HP:0009777)2.61281313
33Absent/shortened dynein arms (HP:0200106)2.57529976
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.57529976
35Abnormality of the renal medulla (HP:0100957)2.57439276
36Myokymia (HP:0002411)2.54397744
37Abnormality of the labia minora (HP:0012880)2.52963827
38Abnormal respiratory motile cilium morphology (HP:0005938)2.50961071
39Abnormal respiratory epithelium morphology (HP:0012253)2.50961071
40Chronic hepatic failure (HP:0100626)2.50394737
41Increased CSF lactate (HP:0002490)2.48541512
42Poor coordination (HP:0002370)2.47333214
43Anencephaly (HP:0002323)2.46883057
44Hepatic necrosis (HP:0002605)2.46607472
45Hepatocellular necrosis (HP:0001404)2.44458774
46Partial duplication of the phalanx of hand (HP:0009999)2.37305453
47Lipid accumulation in hepatocytes (HP:0006561)2.31625826
48Depressed nasal ridge (HP:0000457)2.30159664
49Anomalous pulmonary venous return (HP:0010772)2.26344039
50Progressive cerebellar ataxia (HP:0002073)2.25459499
51Increased hepatocellular lipid droplets (HP:0006565)2.23402131
52Polyphagia (HP:0002591)2.23242491
53Abnormal ciliary motility (HP:0012262)2.22187479
54Cerebral edema (HP:0002181)2.21942795
55Methylmalonic acidemia (HP:0002912)2.21832639
56Cystic liver disease (HP:0006706)2.21479841
57Pendular nystagmus (HP:0012043)2.21232925
58Abnormality of DNA repair (HP:0003254)2.19525524
59Type 2 muscle fiber atrophy (HP:0003554)2.16698275
60Decreased muscle mass (HP:0003199)2.16678301
61Vaginal atresia (HP:0000148)2.12514006
62Tachypnea (HP:0002789)2.11692384
63Sclerocornea (HP:0000647)2.10381698
64Postaxial foot polydactyly (HP:0001830)2.10082829
65Abnormal number of erythroid precursors (HP:0012131)2.09512484
66Renal Fanconi syndrome (HP:0001994)2.09142505
67Pachygyria (HP:0001302)2.07991431
68Optic disc pallor (HP:0000543)2.03697799
69Congenital hepatic fibrosis (HP:0002612)2.03685530
70Abnormality of the aortic arch (HP:0012303)2.02526039
71Genital tract atresia (HP:0001827)2.01431488
72Abnormality of urine glucose concentration (HP:0011016)2.00658690
73Glycosuria (HP:0003076)2.00658690
74Hyperthyroidism (HP:0000836)2.00216484
75Abnormal pupillary function (HP:0007686)1.99576091
76Abnormality of renal resorption (HP:0011038)1.97457020
77Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92174639
78Abnormality of the pulmonary veins (HP:0011718)1.90984129
79Failure to thrive in infancy (HP:0001531)1.89528920
80Muscle fiber atrophy (HP:0100295)1.83899668
81Methylmalonic aciduria (HP:0012120)1.83760393
82Postaxial hand polydactyly (HP:0001162)1.80119381
83Poor suck (HP:0002033)1.79554931
84Abnormal pancreas size (HP:0012094)1.74646026
85Abnormal rod and cone electroretinograms (HP:0008323)1.74208728
86Rectal fistula (HP:0100590)1.72578947
87Rectovaginal fistula (HP:0000143)1.72578947
88Anterior segment dysgenesis (HP:0007700)1.71876973
89Hypoplasia of the pons (HP:0012110)1.71796972
90Partial agenesis of the corpus callosum (HP:0001338)1.71786782
91Adrenal hypoplasia (HP:0000835)1.71445862
92Abolished electroretinogram (ERG) (HP:0000550)1.70441081
93Severe muscular hypotonia (HP:0006829)1.70440771
94Dandy-Walker malformation (HP:0001305)1.69928092
95Left ventricular hypertrophy (HP:0001712)1.69693253
96Congenital stationary night blindness (HP:0007642)1.69521688
97Lissencephaly (HP:0001339)1.67620172
98Holoprosencephaly (HP:0001360)1.67500564
99Hypoplasia of the radius (HP:0002984)1.66838435
100Polyuria (HP:0000103)1.65995441

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B4.21196273
2TLK12.86121704
3PINK12.76152679
4WNK42.71248681
5ADRBK22.60274732
6CDC72.53864895
7PIK3CA2.40427926
8DYRK22.29132514
9PASK2.29121231
10FRK2.24368797
11GRK12.21035393
12ZAK2.16473769
13TRIM282.01129505
14CASK1.98977154
15CDK191.86437420
16CAMKK11.77087354
17TNIK1.72727638
18PHKG21.65669774
19PHKG11.65669774
20PRKCG1.59984794
21NUAK11.59917770
22PDK21.53822759
23TYRO31.53270765
24NEK11.51814659
25MAP2K71.45791917
26NTRK21.45627746
27IRAK11.44904711
28MKNK21.40458447
29LRRK21.33797522
30STK241.30206368
31EPHA31.29487643
32PRKCI1.26883112
33SIK21.25971112
34STK161.23809677
35BCKDK1.17005863
36MAPK131.14818412
37CAMK11.12672153
38NEK21.11740885
39TAOK31.10671578
40BRAF1.02351045
41CAMKK21.01369591
42MAP3K40.99300232
43STK30.96410854
44STK390.96052426
45MKNK10.95461258
46MARK10.90582663
47ACVR1B0.88454219
48PAK30.88130362
49PLK20.87089002
50WNK30.81129453
51MAPK150.80958489
52ALK0.80478883
53PRKCQ0.79801333
54CAMK1D0.78694589
55HIPK20.77334843
56MAP3K110.73452341
57PRKCZ0.73305686
58MINK10.71525799
59CSNK1G20.71183070
60DAPK20.70404730
61PRKCH0.70113561
62NTRK30.68552506
63OXSR10.66803937
64ADRBK10.66388244
65AURKA0.65990655
66STK110.65981076
67CAMK40.64958165
68PRKCD0.64813885
69ARAF0.64192536
70VRK20.63754991
71RPS6KA50.60997604
72PLK10.60556439
73CSNK1G30.59650072
74TAF10.59364560
75DYRK1B0.57772789
76PRKACA0.57580931
77PRKCE0.56882156
78INSRR0.56633388
79CSNK2A20.55715415
80DAPK30.54049771
81MARK20.50233858
82SGK2230.49301806
83SGK4940.49301806
84FGFR20.48335747
85VRK10.47962815
86ITK0.46823100
87CHUK0.46595194
88NME10.44935266
89CHEK20.43749119
90GRK70.43555628
91LIMK10.42829963
92RPS6KA60.42826669
93CAMK2A0.42406272
94PRKACB0.41185429
95CSNK1E0.41018396
96AURKB0.39886524
97DYRK1A0.39192884
98PRKDC0.39176483
99WNK10.38789967
100AKT20.38517921

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.58560303
2Oxidative phosphorylation_Homo sapiens_hsa001903.71467785
3Parkinsons disease_Homo sapiens_hsa050123.24440958
4Sulfur relay system_Homo sapiens_hsa041222.48484908
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.47796536
6Cardiac muscle contraction_Homo sapiens_hsa042602.47243799
7Protein export_Homo sapiens_hsa030602.40325020
8Huntingtons disease_Homo sapiens_hsa050162.21268034
9Alzheimers disease_Homo sapiens_hsa050102.15695200
10Linoleic acid metabolism_Homo sapiens_hsa005912.02782221
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92237982
12RNA polymerase_Homo sapiens_hsa030201.88892250
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82918938
14Fanconi anemia pathway_Homo sapiens_hsa034601.79014389
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76245934
16RNA degradation_Homo sapiens_hsa030181.73512773
17Folate biosynthesis_Homo sapiens_hsa007901.71328631
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69468620
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.69176622
20Phototransduction_Homo sapiens_hsa047441.68996102
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67195764
22Basal transcription factors_Homo sapiens_hsa030221.53174399
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.45870099
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39879005
25Ether lipid metabolism_Homo sapiens_hsa005651.34459095
26Basal cell carcinoma_Homo sapiens_hsa052171.21880810
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21569949
28Arachidonic acid metabolism_Homo sapiens_hsa005901.20767427
29Homologous recombination_Homo sapiens_hsa034401.19197865
30Butanoate metabolism_Homo sapiens_hsa006501.15222004
31Propanoate metabolism_Homo sapiens_hsa006401.13898648
32Tryptophan metabolism_Homo sapiens_hsa003801.12450641
33Peroxisome_Homo sapiens_hsa041461.12227253
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12093626
35Nicotine addiction_Homo sapiens_hsa050331.08451476
36Fat digestion and absorption_Homo sapiens_hsa049751.01825211
37Proteasome_Homo sapiens_hsa030501.00779848
38Pyrimidine metabolism_Homo sapiens_hsa002401.00381595
39Base excision repair_Homo sapiens_hsa034100.99344250
40Ovarian steroidogenesis_Homo sapiens_hsa049130.98739970
41Steroid biosynthesis_Homo sapiens_hsa001000.98195986
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96026871
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.93896852
44Mismatch repair_Homo sapiens_hsa034300.92980288
45Nucleotide excision repair_Homo sapiens_hsa034200.91211512
46Morphine addiction_Homo sapiens_hsa050320.88649510
47Collecting duct acid secretion_Homo sapiens_hsa049660.85298756
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.84577113
49Hedgehog signaling pathway_Homo sapiens_hsa043400.82450097
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81879749
51One carbon pool by folate_Homo sapiens_hsa006700.80765140
52Insulin secretion_Homo sapiens_hsa049110.79414591
53Asthma_Homo sapiens_hsa053100.77076365
54Glutamatergic synapse_Homo sapiens_hsa047240.74631086
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72062046
56DNA replication_Homo sapiens_hsa030300.72049802
57Metabolic pathways_Homo sapiens_hsa011000.69903702
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66195326
59Pyruvate metabolism_Homo sapiens_hsa006200.64691377
60Chemical carcinogenesis_Homo sapiens_hsa052040.64598321
61Hippo signaling pathway_Homo sapiens_hsa043900.62304743
62Purine metabolism_Homo sapiens_hsa002300.61348737
63Selenocompound metabolism_Homo sapiens_hsa004500.60210358
64Serotonergic synapse_Homo sapiens_hsa047260.60134411
65Olfactory transduction_Homo sapiens_hsa047400.60050178
66p53 signaling pathway_Homo sapiens_hsa041150.59578131
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59201431
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57774214
69Synaptic vesicle cycle_Homo sapiens_hsa047210.52586165
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.52273341
71Retinol metabolism_Homo sapiens_hsa008300.50938718
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49980386
73Caffeine metabolism_Homo sapiens_hsa002320.48539920
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48361823
75Nitrogen metabolism_Homo sapiens_hsa009100.46524453
76Notch signaling pathway_Homo sapiens_hsa043300.45551696
77Glycerolipid metabolism_Homo sapiens_hsa005610.45151675
78Non-homologous end-joining_Homo sapiens_hsa034500.43936288
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43440151
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43207615
81Taste transduction_Homo sapiens_hsa047420.43125299
82GABAergic synapse_Homo sapiens_hsa047270.42208443
83Long-term depression_Homo sapiens_hsa047300.40180083
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38603155
85beta-Alanine metabolism_Homo sapiens_hsa004100.38149406
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36662956
87Regulation of autophagy_Homo sapiens_hsa041400.36187712
88Systemic lupus erythematosus_Homo sapiens_hsa053220.36113962
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33159331
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33091015
91RNA transport_Homo sapiens_hsa030130.33078624
92Dopaminergic synapse_Homo sapiens_hsa047280.32219827
93Axon guidance_Homo sapiens_hsa043600.32016346
94Alcoholism_Homo sapiens_hsa050340.30378226
95Salivary secretion_Homo sapiens_hsa049700.29696993
96Oxytocin signaling pathway_Homo sapiens_hsa049210.27889701
97Fatty acid degradation_Homo sapiens_hsa000710.27269063
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.26142023
99Circadian entrainment_Homo sapiens_hsa047130.26003962
100Arginine and proline metabolism_Homo sapiens_hsa003300.25672443

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