RPL31P47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hematopoietic stem cell differentiation (GO:0060218)9.43213833
2base-excision repair, AP site formation (GO:0006285)6.71211825
3cerebral cortex radially oriented cell migration (GO:0021799)6.29052527
4sulfate transmembrane transport (GO:1902358)6.03157253
5protein polyglutamylation (GO:0018095)5.68122432
6sulfate transport (GO:0008272)5.39975839
7cholesterol catabolic process (GO:0006707)5.21758641
8sterol catabolic process (GO:0016127)5.21758641
9mitochondrial calcium ion homeostasis (GO:0051560)4.96513648
10virion assembly (GO:0019068)4.70909720
11protein K6-linked ubiquitination (GO:0085020)4.69679077
12viral protein processing (GO:0019082)4.62606091
13acrosome assembly (GO:0001675)4.52742780
14mRNA modification (GO:0016556)4.51190491
15seminiferous tubule development (GO:0072520)4.49163352
16response to gravity (GO:0009629)4.47348586
17regulation of cholesterol homeostasis (GO:2000188)4.44170369
18positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc4.28530666
19DNA damage response, detection of DNA damage (GO:0042769)4.26991613
20positive regulation of mitochondrial membrane permeability (GO:0035794)4.24127180
21cytidine deamination (GO:0009972)4.17376786
22cytidine metabolic process (GO:0046087)4.17376786
23cytidine catabolic process (GO:0006216)4.17376786
24melanocyte differentiation (GO:0030318)4.10925086
25negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.05803502
26DNA catabolic process, exonucleolytic (GO:0000738)3.99309216
27detection of light stimulus involved in visual perception (GO:0050908)3.90044777
28detection of light stimulus involved in sensory perception (GO:0050962)3.90044777
29behavioral response to nicotine (GO:0035095)3.90035311
30positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.85023756
31regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.85023756
32pigment cell differentiation (GO:0050931)3.79926492
33regulation of synapse maturation (GO:0090128)3.77084723
34cell proliferation in forebrain (GO:0021846)3.65822249
35dicarboxylic acid catabolic process (GO:0043649)3.65550179
36negative regulation of keratinocyte proliferation (GO:0010839)3.65045470
37dopamine transport (GO:0015872)3.59931667
38mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.51591247
39positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.51591247
40pyrimidine ribonucleoside catabolic process (GO:0046133)3.48490973
41regulation of MHC class I biosynthetic process (GO:0045343)3.47453667
42positive regulation of cellular amide metabolic process (GO:0034250)3.45001740
43DNA replication-dependent nucleosome assembly (GO:0006335)3.43319214
44DNA replication-dependent nucleosome organization (GO:0034723)3.43319214
45regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.40639210
46regulation of megakaryocyte differentiation (GO:0045652)3.40396975
47cellular response to ATP (GO:0071318)3.38439675
48alkaloid metabolic process (GO:0009820)3.36295714
49regulation of protein glycosylation (GO:0060049)3.34866520
50lipoprotein transport (GO:0042953)3.34803518
51DNA double-strand break processing (GO:0000729)3.34453530
52TOR signaling (GO:0031929)3.29129146
53signal peptide processing (GO:0006465)3.27796273
54embryonic digestive tract morphogenesis (GO:0048557)3.26727445
55sodium-independent organic anion transport (GO:0043252)3.26337811
56base-excision repair (GO:0006284)3.25823204
57mammary gland epithelial cell proliferation (GO:0033598)3.23463431
58regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.22063039
59L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.20831415
60pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.20497467
61regulation of metalloenzyme activity (GO:0048552)3.19057154
62protein-cofactor linkage (GO:0018065)3.17502990
63regulation of cilium movement (GO:0003352)3.16897357
64positive regulation of protein kinase C signaling (GO:0090037)3.14857210
65positive regulation of erythrocyte differentiation (GO:0045648)3.13409675
66DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.13309205
67histone deubiquitination (GO:0016578)3.10831801
68neural tube formation (GO:0001841)3.09835635
69keratinocyte development (GO:0003334)3.07586367
70regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.06857292
71regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.05144725
72positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.04523696
73regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.04523696
74positive regulation of megakaryocyte differentiation (GO:0045654)3.03551436
75mitochondrial genome maintenance (GO:0000002)3.00520641
76entrainment of circadian clock (GO:0009649)2.97792017
77entrainment of circadian clock by photoperiod (GO:0043153)2.96851262
78neuroepithelial cell differentiation (GO:0060563)2.94808049
79negative regulation of actin filament bundle assembly (GO:0032232)2.94646618
80regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:22.94433527
81negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.87172380
82regulation of beta-amyloid formation (GO:1902003)2.85331327
83positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.84903154
84regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.84903154
85mucosal-associated lymphoid tissue development (GO:0048537)2.84803326
86Peyers patch development (GO:0048541)2.84803326
87positive regulation of calcium ion import (GO:0090280)2.84096901
88adaptation of signaling pathway (GO:0023058)2.83729291
89amino acid salvage (GO:0043102)2.82439565
90L-methionine salvage (GO:0071267)2.82439565
91L-methionine biosynthetic process (GO:0071265)2.82439565
92cerebral cortex cell migration (GO:0021795)2.81058390
93retinal cone cell development (GO:0046549)2.80766213
94positive regulation of astrocyte differentiation (GO:0048711)2.80476066
95positive regulation of extracellular matrix organization (GO:1903055)2.79998641
96cellular response to reactive nitrogen species (GO:1902170)2.77840683
97sulfur compound transport (GO:0072348)2.77499419
98steroid catabolic process (GO:0006706)2.76067818
99L-fucose catabolic process (GO:0042355)2.75226882
100L-fucose metabolic process (GO:0042354)2.75226882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.70669821
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.23154584
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.45950015
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.05941801
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.77272152
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.48723219
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.48723219
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.48723219
9EZH2_22144423_ChIP-Seq_EOC_Human3.22625613
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70623085
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.67059211
12ZNF274_21170338_ChIP-Seq_K562_Hela2.60833641
13ESR1_15608294_ChIP-ChIP_MCF-7_Human2.46811088
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.37612354
15DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.36977842
16VDR_22108803_ChIP-Seq_LS180_Human2.13683479
17CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.86340538
18NOTCH1_21737748_ChIP-Seq_TLL_Human1.71540559
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.66879430
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62954677
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61995975
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53261258
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51226419
24FUS_26573619_Chip-Seq_HEK293_Human1.49540891
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44666679
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44564762
27P300_19829295_ChIP-Seq_ESCs_Human1.44533633
28NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42994905
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.41117958
30EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.41024782
31TCF4_22108803_ChIP-Seq_LS180_Human1.38880150
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37673177
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.36898704
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35561266
35AHR_22903824_ChIP-Seq_MCF-7_Human1.33145032
36IRF1_19129219_ChIP-ChIP_H3396_Human1.32978480
37ER_23166858_ChIP-Seq_MCF-7_Human1.31279591
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28507290
39SOX2_19829295_ChIP-Seq_ESCs_Human1.27707452
40NANOG_19829295_ChIP-Seq_ESCs_Human1.27707452
41TP53_22573176_ChIP-Seq_HFKS_Human1.27532789
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25795781
43ERG_20517297_ChIP-Seq_VCAP_Human1.22227781
44BCAT_22108803_ChIP-Seq_LS180_Human1.21287958
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19961179
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.16663744
47IGF1R_20145208_ChIP-Seq_DFB_Human1.16145271
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15771656
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15676861
50AR_25329375_ChIP-Seq_VCAP_Human1.14349035
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.14183734
52JUN_21703547_ChIP-Seq_K562_Human1.13363078
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13224652
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12218000
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11481211
56CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10165537
57FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07957936
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06707203
59STAT3_23295773_ChIP-Seq_U87_Human1.06374882
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05379909
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.05275213
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.04023816
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.02092267
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.01996197
65DROSHA_22980978_ChIP-Seq_HELA_Human1.01440068
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01419691
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00599513
68HOXB7_26014856_ChIP-Seq_BT474_Human0.98815205
69FOXA1_25329375_ChIP-Seq_VCAP_Human0.97128142
70FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97128142
71CJUN_26792858_Chip-Seq_BT549_Human0.94636707
72EP300_21415370_ChIP-Seq_HL-1_Mouse0.93911082
73POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93130410
74GABP_17652178_ChIP-ChIP_JURKAT_Human0.92510385
75NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91712056
76CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90878872
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89820228
78CRX_20693478_ChIP-Seq_RETINA_Mouse0.89628540
79GBX2_23144817_ChIP-Seq_PC3_Human0.88568146
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88407390
81SMAD4_21799915_ChIP-Seq_A2780_Human0.88225825
82REST_21632747_ChIP-Seq_MESCs_Mouse0.87452167
83EST1_17652178_ChIP-ChIP_JURKAT_Human0.86675395
84SALL4_22934838_ChIP-ChIP_CD34+_Human0.86005451
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85294367
86POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85167995
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84950113
88GATA3_26560356_Chip-Seq_TH2_Human0.84376977
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82025085
90SOX2_16153702_ChIP-ChIP_HESCs_Human0.81674842
91BRD4_25478319_ChIP-Seq_HGPS_Human0.81028610
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80808440
93CTBP1_25329375_ChIP-Seq_LNCAP_Human0.80683364
94EWS_26573619_Chip-Seq_HEK293_Human0.80356252
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.80205723
96RUNX2_22187159_ChIP-Seq_PCA_Human0.79718277
97OCT4_21477851_ChIP-Seq_ESCs_Mouse0.79556006
98ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79303690
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.78553238
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.77270812

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue8.20389913
2MP0008004_abnormal_stomach_pH7.60078917
3MP0000003_abnormal_adipose_tissue4.83402826
4MP0001984_abnormal_olfaction3.22283817
5MP0001502_abnormal_circadian_rhythm3.10792560
6MP0002736_abnormal_nociception_after2.95805187
7MP0003787_abnormal_imprinting2.95652602
8MP0001986_abnormal_taste_sensitivity2.33727931
9MP0001501_abnormal_sleep_pattern2.14778096
10MP0006054_spinal_hemorrhage2.11972619
11MP0005551_abnormal_eye_electrophysiolog2.08755637
12MP0001968_abnormal_touch/_nociception2.06664191
13MP0004885_abnormal_endolymph2.05456345
14MP0002933_joint_inflammation2.01386072
15MP0006072_abnormal_retinal_apoptosis1.90524325
16MP0009250_abnormal_appendicular_skeleto1.61692907
17MP0004742_abnormal_vestibular_system1.59540271
18MP0000371_diluted_coat_color1.58842229
19MP0000538_abnormal_urinary_bladder1.56922445
20MP0008961_abnormal_basal_metabolism1.55548667
21MP0003195_calcinosis1.54747057
22MP0003950_abnormal_plasma_membrane1.52942115
23MP0006292_abnormal_olfactory_placode1.52123222
24MP0005375_adipose_tissue_phenotype1.48500593
25MP0004484_altered_response_of1.41898603
26MP0005253_abnormal_eye_physiology1.39865689
27MP0008875_abnormal_xenobiotic_pharmacok1.37970251
28MP0004233_abnormal_muscle_weight1.37704940
29MP0004145_abnormal_muscle_electrophysio1.36616457
30MP0001486_abnormal_startle_reflex1.34888788
31MP0001485_abnormal_pinna_reflex1.29912995
32MP0002733_abnormal_thermal_nociception1.26244743
33MP0005646_abnormal_pituitary_gland1.20913034
34MP0003693_abnormal_embryo_hatching1.19696614
35MP0005367_renal/urinary_system_phenotyp1.17420318
36MP0000516_abnormal_urinary_system1.17420318
37MP0000427_abnormal_hair_cycle1.16973097
38MP0004142_abnormal_muscle_tone1.16285545
39MP0009278_abnormal_bone_marrow1.14521943
40MP0009046_muscle_twitch1.14446379
41MP0003011_delayed_dark_adaptation1.11780098
42MP0008877_abnormal_DNA_methylation1.07495381
43MP0010307_abnormal_tumor_latency1.05462144
44MP0002572_abnormal_emotion/affect_behav1.04269300
45MP0005410_abnormal_fertilization1.00477561
46MP0001970_abnormal_pain_threshold0.97653739
47MP0001440_abnormal_grooming_behavior0.97569305
48MP0000470_abnormal_stomach_morphology0.97208969
49MP0002735_abnormal_chemical_nociception0.95815519
50MP0008058_abnormal_DNA_repair0.93771386
51MP0005377_hearing/vestibular/ear_phenot0.92995145
52MP0003878_abnormal_ear_physiology0.92995145
53MP0005076_abnormal_cell_differentiation0.89159930
54MP0002234_abnormal_pharynx_morphology0.85391798
55MP0002653_abnormal_ependyma_morphology0.83081390
56MP0008872_abnormal_physiological_respon0.80978311
57MP0010368_abnormal_lymphatic_system0.79146829
58MP0005386_behavior/neurological_phenoty0.78338949
59MP0004924_abnormal_behavior0.78338949
60MP0010329_abnormal_lipoprotein_level0.76475120
61MP0002272_abnormal_nervous_system0.75608892
62MP0003635_abnormal_synaptic_transmissio0.74933504
63MP0004019_abnormal_vitamin_homeostasis0.74703384
64MP0003121_genomic_imprinting0.70750987
65MP0003646_muscle_fatigue0.69942010
66MP0003879_abnormal_hair_cell0.69791179
67MP0001919_abnormal_reproductive_system0.68979422
68MP0009115_abnormal_fat_cell0.67249223
69MP0005671_abnormal_response_to0.67005318
70MP0010386_abnormal_urinary_bladder0.66279379
71MP0002876_abnormal_thyroid_physiology0.65753693
72MP0002896_abnormal_bone_mineralization0.65420027
73MP0005334_abnormal_fat_pad0.65110843
74MP0009745_abnormal_behavioral_response0.64596239
75MP0000627_abnormal_mammary_gland0.64419946
76MP0002210_abnormal_sex_determination0.64298502
77MP0002135_abnormal_kidney_morphology0.63614980
78MP0002557_abnormal_social/conspecific_i0.61015135
79MP0003718_maternal_effect0.59865688
80MP0005310_abnormal_salivary_gland0.59496595
81MP0009764_decreased_sensitivity_to0.58443607
82MP0000631_abnormal_neuroendocrine_gland0.58219655
83MP0002638_abnormal_pupillary_reflex0.58206016
84MP0001800_abnormal_humoral_immune0.57812473
85MP0008775_abnormal_heart_ventricle0.56642800
86MP0002229_neurodegeneration0.56271193
87MP0002064_seizures0.56212278
88MP0001929_abnormal_gametogenesis0.56158766
89MP0002118_abnormal_lipid_homeostasis0.53748235
90MP0001666_abnormal_nutrient_absorption0.52549276
91MP0005332_abnormal_amino_acid0.49908456
92MP0002063_abnormal_learning/memory/cond0.49788383
93MP0005452_abnormal_adipose_tissue0.49503870
94MP0002067_abnormal_sensory_capabilities0.49358392
95MP0001764_abnormal_homeostasis0.47324394
96MP0000579_abnormal_nail_morphology0.46932342
97MP0002136_abnormal_kidney_physiology0.46883459
98MP0000653_abnormal_sex_gland0.46848208
99MP0008995_early_reproductive_senescence0.46731228
100MP0002282_abnormal_trachea_morphology0.46260702

Predicted human phenotypes

RankGene SetZ-score
1Stomach cancer (HP:0012126)6.00978314
2Renal cortical cysts (HP:0000803)5.70602295
3Generalized hypopigmentation of hair (HP:0011358)5.02347938
4Abnormality of the renal cortex (HP:0011035)4.87661928
5Aplasia/Hypoplasia of the fovea (HP:0008060)4.86691233
6Hypoplasia of the fovea (HP:0007750)4.86691233
7Prominent supraorbital ridges (HP:0000336)4.59014122
8Abnormality of lateral ventricle (HP:0030047)4.10524789
9Colon cancer (HP:0003003)4.02254555
10Anterior segment dysgenesis (HP:0007700)3.96357618
11Abnormality of the fovea (HP:0000493)3.66267962
12Woolly hair (HP:0002224)3.60264918
13Chronic hepatic failure (HP:0100626)3.45751562
14Proximal amyotrophy (HP:0007126)3.36480805
15Abnormal hair laboratory examination (HP:0003328)3.30565432
16Intellectual disability, moderate (HP:0002342)3.16656478
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.16023780
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.16023780
19Generalized hypopigmentation (HP:0007513)3.13370369
20Vacuolated lymphocytes (HP:0001922)3.12923509
21Conical tooth (HP:0000698)3.02530388
22Hypoalbuminemia (HP:0003073)2.96675714
23Abnormal albumin level (HP:0012116)2.96675714
24Abnormality of the renal medulla (HP:0100957)2.88191129
25Aplasia/Hypoplasia of the macula (HP:0008059)2.87153265
26Volvulus (HP:0002580)2.79542481
27Molar tooth sign on MRI (HP:0002419)2.77791122
28Abnormality of midbrain morphology (HP:0002418)2.77791122
29Polyuria (HP:0000103)2.72727426
30Aplasia/Hypoplasia affecting the retina (HP:0008061)2.63934588
31Hypoplastic labia majora (HP:0000059)2.63756783
32Polydipsia (HP:0001959)2.61086621
33Abnormal drinking behavior (HP:0030082)2.61086621
34Abnormality of the proximal phalanges of the hand (HP:0009834)2.56293504
35Overlapping toe (HP:0001845)2.53764012
36Congenital, generalized hypertrichosis (HP:0004540)2.45484372
37Abnormality of the labia majora (HP:0012881)2.43898246
38Abnormality of sulfur amino acid metabolism (HP:0004339)2.41331067
39Prominent forehead (HP:0011220)2.40951146
40Wormian bones (HP:0002645)2.40941453
41Congenital stationary night blindness (HP:0007642)2.39922935
42True hermaphroditism (HP:0010459)2.39383897
43Curly hair (HP:0002212)2.35127082
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.35024439
45Nephronophthisis (HP:0000090)2.34958611
46Ocular albinism (HP:0001107)2.33636233
47Abnormality of methionine metabolism (HP:0010901)2.31070863
48Chorioretinal coloboma (HP:0000567)2.30584533
49Nausea (HP:0002018)2.28792430
50Scrotal hypoplasia (HP:0000046)2.28159380
51Thrombocytosis (HP:0001894)2.25517949
52Abnormal urine output (HP:0012590)2.24949955
53Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.24190949
54Flat capital femoral epiphysis (HP:0003370)2.23016943
55Abnormal number of incisors (HP:0011064)2.21907847
56Absent speech (HP:0001344)2.18514548
57Brittle hair (HP:0002299)2.18148819
58Patellar aplasia (HP:0006443)2.17115287
59Abnormality of dental color (HP:0011073)2.15214162
60Hyperaldosteronism (HP:0000859)2.14831207
61Abnormality of small intestinal villus morphology (HP:0011472)2.13103293
62Villous atrophy (HP:0011473)2.13103293
63Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11764483
64Thyroid-stimulating hormone excess (HP:0002925)2.11413304
65Neoplasm of the oral cavity (HP:0100649)2.08826117
66Aplasia/Hypoplasia of the patella (HP:0006498)2.04786793
67Febrile seizures (HP:0002373)2.04527460
68Broad alveolar ridges (HP:0000187)2.02437200
69Tracheomalacia (HP:0002779)2.01561485
70Subacute progressive viral hepatitis (HP:0006572)2.01274736
71IgG deficiency (HP:0004315)2.00970474
72Hepatocellular necrosis (HP:0001404)1.99126289
73Hypoplasia of the thymus (HP:0000778)1.97986602
74Small epiphyses (HP:0010585)1.96614349
75Broad-based gait (HP:0002136)1.94713958
76Pancreatic cysts (HP:0001737)1.94454959
77Tetraplegia (HP:0002445)1.94000882
78Chronic diarrhea (HP:0002028)1.92021288
79Iris hypopigmentation (HP:0007730)1.91510998
80Abnormality of alanine metabolism (HP:0010916)1.91134917
81Hyperalaninemia (HP:0003348)1.91134917
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91134917
83Hypokalemic alkalosis (HP:0001949)1.88963034
84Abnormality of the incisor (HP:0000676)1.87399527
85Abnormality of macular pigmentation (HP:0008002)1.87263054
86Supernumerary bones of the axial skeleton (HP:0009144)1.87099680
87Abnormality of renal excretion (HP:0011036)1.86715790
88Pancreatic fibrosis (HP:0100732)1.85712725
89Optic nerve hypoplasia (HP:0000609)1.82172939
90Autoimmune hemolytic anemia (HP:0001890)1.82062464
91Optic disc pallor (HP:0000543)1.82010978
92Abnormal number of erythroid precursors (HP:0012131)1.81604542
93Abnormal gallbladder physiology (HP:0012438)1.81490887
94Cholecystitis (HP:0001082)1.81490887
95Postnatal microcephaly (HP:0005484)1.79221979
96Aortic regurgitation (HP:0001659)1.79208815
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78400239
98Abnormality of transition element cation homeostasis (HP:0011030)1.76538529
99Sclerocornea (HP:0000647)1.74012454
100Abnormality of iron homeostasis (HP:0011031)1.73753190

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.97034137
2TLK17.00095718
3ZAK6.13586484
4TRIM283.05645181
5BCKDK2.70031151
6PDK22.45703565
7VRK12.28505521
8CCNB12.22495615
9EPHA32.11860707
10MST41.98807521
11KDR1.97809460
12PNCK1.94779365
13WNK31.81975955
14PHKG11.65055137
15PHKG21.65055137
16NEK61.50926360
17FLT31.46663865
18WEE11.41806849
19PKN11.36516583
20NUAK11.33279206
21STK38L1.31401239
22TSSK61.28437171
23PRKD31.27270171
24FRK1.14703993
25DAPK21.12841515
26RPS6KA51.12803301
27VRK21.07894378
28PIM11.05974063
29STK391.02414298
30CDK120.93089611
31STK240.91979245
32WNK40.91628262
33GRK50.86500684
34IKBKB0.85275472
35TNIK0.81239587
36MKNK20.76109433
37PRKCQ0.68877983
38DYRK20.68520069
39PINK10.61111330
40MAP4K20.60911982
41SIK30.60037283
42MAP3K140.58751387
43MAPK130.57416530
44MAPKAPK50.55867770
45CAMKK20.55530367
46DAPK10.53808785
47ROCK10.52770808
48MAP2K20.52638018
49PRKCI0.52091948
50MAPKAPK30.48877979
51OXSR10.48830137
52AKT20.46894960
53JAK10.46149856
54CHUK0.42170551
55CHEK20.41231688
56MAP3K120.40901317
57PRKAA10.40045202
58CDK60.39382574
59MKNK10.39028595
60BRSK20.37428501
61STK40.36782043
62ADRBK10.36177018
63BMPR20.33202201
64MAPK140.32066074
65IKBKE0.31581541
66MAPK70.29662304
67NTRK10.29462845
68LRRK20.28768964
69MAP3K50.28523306
70CAMK1G0.28288770
71PLK40.27683458
72TAF10.27438204
73PRKAA20.27362435
74MARK10.27050822
75DAPK30.25236679
76NLK0.24805310
77MAPK90.23663848
78MELK0.23563298
79GRK10.23408323
80CSNK1A1L0.22839638
81CDK40.22387750
82RPS6KA60.21010631
83MET0.20324237
84ERBB40.19973139
85CSNK1G30.19947236
86PIK3CA0.18399698
87GRK70.17101425
88BMPR1B0.16004163
89TAOK30.15591790
90STK100.14785090
91LATS20.14726075
92PKN20.13872554
93EIF2AK20.13535098
94RPS6KA20.13240757
95RPS6KA10.12002903
96TRPM70.11948228
97HIPK20.11883587
98TIE10.11568845
99DYRK1A0.11531518
100NTRK20.11077358

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034104.41146432
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29925290
3Caffeine metabolism_Homo sapiens_hsa002323.08596815
4Selenocompound metabolism_Homo sapiens_hsa004502.85136512
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.75360098
6Protein export_Homo sapiens_hsa030602.48762723
7Systemic lupus erythematosus_Homo sapiens_hsa053222.24194044
8Butanoate metabolism_Homo sapiens_hsa006502.10558544
9Proteasome_Homo sapiens_hsa030501.89564409
10Circadian rhythm_Homo sapiens_hsa047101.88721394
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87134529
12Mineral absorption_Homo sapiens_hsa049781.79530780
13Phototransduction_Homo sapiens_hsa047441.60918438
14Alcoholism_Homo sapiens_hsa050341.52478513
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51021234
16Linoleic acid metabolism_Homo sapiens_hsa005911.50738377
17Retinol metabolism_Homo sapiens_hsa008301.49670862
18Nicotine addiction_Homo sapiens_hsa050331.48332958
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46863004
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44292045
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44206025
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40383375
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39485075
24Oxidative phosphorylation_Homo sapiens_hsa001901.36616338
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33950400
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33642987
27Cardiac muscle contraction_Homo sapiens_hsa042601.31952320
28RNA degradation_Homo sapiens_hsa030181.29013597
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28995190
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25941377
31Tyrosine metabolism_Homo sapiens_hsa003501.21177806
32Parkinsons disease_Homo sapiens_hsa050121.17335146
33Propanoate metabolism_Homo sapiens_hsa006401.16871873
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.16678178
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.15788551
36Chemical carcinogenesis_Homo sapiens_hsa052041.14979580
37beta-Alanine metabolism_Homo sapiens_hsa004101.14966466
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14328027
39Steroid biosynthesis_Homo sapiens_hsa001001.11204071
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08894794
41Lysine degradation_Homo sapiens_hsa003101.06979156
42Salivary secretion_Homo sapiens_hsa049701.05480405
43Olfactory transduction_Homo sapiens_hsa047401.03248296
44Fructose and mannose metabolism_Homo sapiens_hsa000511.02730376
45Primary immunodeficiency_Homo sapiens_hsa053401.02379931
46RNA polymerase_Homo sapiens_hsa030200.94967959
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94676891
48Fatty acid degradation_Homo sapiens_hsa000710.94283189
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94242684
50Arginine and proline metabolism_Homo sapiens_hsa003300.88943524
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88648805
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.85326058
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.84977097
54Morphine addiction_Homo sapiens_hsa050320.83237467
55Calcium signaling pathway_Homo sapiens_hsa040200.82985114
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82446977
57Dorso-ventral axis formation_Homo sapiens_hsa043200.81829754
58Asthma_Homo sapiens_hsa053100.81015650
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79114043
60Fanconi anemia pathway_Homo sapiens_hsa034600.78391008
61Alzheimers disease_Homo sapiens_hsa050100.76259887
62Tryptophan metabolism_Homo sapiens_hsa003800.75598604
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74047497
64Circadian entrainment_Homo sapiens_hsa047130.72093017
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72035876
66Huntingtons disease_Homo sapiens_hsa050160.68889946
67Phenylalanine metabolism_Homo sapiens_hsa003600.67833300
68Taste transduction_Homo sapiens_hsa047420.64917144
69Renin secretion_Homo sapiens_hsa049240.64689926
70Gastric acid secretion_Homo sapiens_hsa049710.64031501
71Glycerolipid metabolism_Homo sapiens_hsa005610.63284324
72Amphetamine addiction_Homo sapiens_hsa050310.61940402
73Estrogen signaling pathway_Homo sapiens_hsa049150.61213748
74Regulation of autophagy_Homo sapiens_hsa041400.60807821
75FoxO signaling pathway_Homo sapiens_hsa040680.59770657
76Dopaminergic synapse_Homo sapiens_hsa047280.57321382
77Insulin secretion_Homo sapiens_hsa049110.56116088
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55888450
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53912374
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53138571
81Histidine metabolism_Homo sapiens_hsa003400.53040497
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52307641
83Pancreatic secretion_Homo sapiens_hsa049720.50362619
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47729850
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46840553
86Nitrogen metabolism_Homo sapiens_hsa009100.43831110
87Serotonergic synapse_Homo sapiens_hsa047260.43659871
88PPAR signaling pathway_Homo sapiens_hsa033200.42527187
89Viral carcinogenesis_Homo sapiens_hsa052030.40578247
90One carbon pool by folate_Homo sapiens_hsa006700.39544542
91Oxytocin signaling pathway_Homo sapiens_hsa049210.37850852
92Fatty acid metabolism_Homo sapiens_hsa012120.37726649
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33893185
94Spliceosome_Homo sapiens_hsa030400.33228953
95Ribosome_Homo sapiens_hsa030100.30591041
96TNF signaling pathway_Homo sapiens_hsa046680.28974245
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27495229
98GABAergic synapse_Homo sapiens_hsa047270.27422312
99Ovarian steroidogenesis_Homo sapiens_hsa049130.27245953
100Bile secretion_Homo sapiens_hsa049760.26959260

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