ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.66717086
2	ribosomal small subunit assembly (GO:0000028)	7.35759690
3	translational termination (GO:0006415)	7.35687730
4	translational elongation (GO:0006414)	6.43823775
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.19943918
6	ribosomal small subunit biogenesis (GO:0042274)	6.11379217
7	cotranslational protein targeting to membrane (GO:0006613)	6.08518011
8	protein targeting to ER (GO:0045047)	6.05139003
9	maturation of SSU-rRNA (GO:0030490)	5.92062120
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.80091346
11	protein localization to endoplasmic reticulum (GO:0070972)	5.68911056
12	cellular protein complex disassembly (GO:0043624)	5.57753835
13	viral life cycle (GO:0019058)	5.41862113
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.29604204
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.09427482
16	ATP synthesis coupled proton transport (GO:0015986)	5.09427482
17	behavioral response to nicotine (GO:0035095)	5.00320483
18	translational initiation (GO:0006413)	4.77059503
19	chaperone-mediated protein transport (GO:0072321)	4.70642393
20	protein complex disassembly (GO:0043241)	4.68741144
21	macromolecular complex disassembly (GO:0032984)	4.47884542
22	DNA deamination (GO:0045006)	4.46179764
23	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.43489908
24	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.42154889
25	protein neddylation (GO:0045116)	4.36402888
26	nucleotide salvage (GO:0043173)	4.20358992
27	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.18909150
28	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.18909150
29	translation (GO:0006412)	4.15388685
30	ribosomal large subunit biogenesis (GO:0042273)	4.12547545
31	protein targeting to membrane (GO:0006612)	3.96750395
32	respiratory electron transport chain (GO:0022904)	3.75970408
33	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.74232328
34	electron transport chain (GO:0022900)	3.74000737
35	CTP metabolic process (GO:0046036)	3.73053866
36	CTP biosynthetic process (GO:0006241)	3.73053866
37	protein complex biogenesis (GO:0070271)	3.68082932
38	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.66641545
39	water-soluble vitamin biosynthetic process (GO:0042364)	3.51647430
40	mRNA catabolic process (GO:0006402)	3.50986701
41	nucleoside salvage (GO:0043174)	3.49320260
42	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.46914572
43	NADH dehydrogenase complex assembly (GO:0010257)	3.46914572
44	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.46914572
45	mitochondrial respiratory chain complex assembly (GO:0033108)	3.41708948
46	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.40137738
47	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.37267555
48	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.30557993
49	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.18899216
50	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	3.18311216
51	UMP biosynthetic process (GO:0006222)	3.18311216
52	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	3.18311216
53	UMP metabolic process (GO:0046049)	3.18311216
54	purine nucleotide salvage (GO:0032261)	3.16394685
55	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.16102315
56	pyrimidine nucleotide catabolic process (GO:0006244)	3.14152219
57	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.14131512
58	RNA catabolic process (GO:0006401)	3.12939924
59	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.12789218
60	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.12110234
61	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.07781508
62	cellular component biogenesis (GO:0044085)	3.05282128
63	ATP biosynthetic process (GO:0006754)	3.03371822
64	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.02464170
65	hydrogen ion transmembrane transport (GO:1902600)	2.99304772
66	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.97649674
67	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.95863666
68	ribonucleoprotein complex biogenesis (GO:0022613)	2.95623650
69	pseudouridine synthesis (GO:0001522)	2.95406015
70	metallo-sulfur cluster assembly (GO:0031163)	2.93919935
71	iron-sulfur cluster assembly (GO:0016226)	2.93919935
72	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.93323143
73	termination of RNA polymerase III transcription (GO:0006386)	2.77081912
74	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.77081912
75	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.74231649
76	pyrimidine nucleoside salvage (GO:0043097)	2.73600983
77	pyrimidine-containing compound salvage (GO:0008655)	2.73600983
78	GTP biosynthetic process (GO:0006183)	2.72087839
79	establishment of protein localization to membrane (GO:0090150)	2.71767910
80	proton transport (GO:0015992)	2.70480560
81	response to pheromone (GO:0019236)	2.70419663
82	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.70152621
83	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.69852060
84	indolalkylamine metabolic process (GO:0006586)	2.67222033
85	S-adenosylmethionine metabolic process (GO:0046500)	2.66804001
86	nucleoside triphosphate biosynthetic process (GO:0009142)	2.65941109
87	protein targeting (GO:0006605)	2.65041605
88	hydrogen transport (GO:0006818)	2.64695468
89	piRNA metabolic process (GO:0034587)	2.59984223
90	protein-cofactor linkage (GO:0018065)	2.58059727
91	L-methionine salvage (GO:0071267)	2.57993757
92	L-methionine biosynthetic process (GO:0071265)	2.57993757
93	amino acid salvage (GO:0043102)	2.57993757
94	rRNA metabolic process (GO:0016072)	2.57086745
95	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.56749950
96	cell proliferation in forebrain (GO:0021846)	2.56029197
97	regulation of glycogen (starch) synthase activity (GO:2000465)	2.55085087
98	regulation of activation of Janus kinase activity (GO:0010533)	2.52969773
99	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.50801637
100	activation of MAPKKK activity (GO:0000185)	2.49712956

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.21843367
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.14825035
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.08598415
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.56253375
5	VDR_22108803_ChIP-Seq_LS180_Human	2.52968521
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.51796588
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.45077377
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.25154752
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.23518532
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.12925127
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.12574876
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.02610686
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.02278931
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.93832813
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.90374500
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.83869820
17	TP53_22573176_ChIP-Seq_HFKS_Human	1.80221984
18	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.77872459
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.76810864
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73131109
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.72407560
22	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.61971499
23	VDR_23849224_ChIP-Seq_CD4+_Human	1.60146151
24	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.60085812
25	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.58947895
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.52547343
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.51905233
28	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.51580005
29	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.48467171
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.45518156
31	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.45206880
32	NCOR_22424771_ChIP-Seq_293T_Human	1.44174239
33	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.40616784
34	ERA_21632823_ChIP-Seq_H3396_Human	1.40315523
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.39561243
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.39485359
37	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.37687561
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35613683
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.35096359
40	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.32987379
41	TAF2_19829295_ChIP-Seq_ESCs_Human	1.32795204
42	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.30592255
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29401783
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.29162525
45	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.29079657
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29002236
47	TTF2_22483619_ChIP-Seq_HELA_Human	1.27719732
48	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.24777252
49	AR_20517297_ChIP-Seq_VCAP_Human	1.24691577
50	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.23816616
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.22739303
52	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.22577082
53	FUS_26573619_Chip-Seq_HEK293_Human	1.21358124
54	ELK1_19687146_ChIP-ChIP_HELA_Human	1.17072906
55	NANOG_20526341_ChIP-Seq_ESCs_Human	1.16400099
56	EWS_26573619_Chip-Seq_HEK293_Human	1.16022651
57	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.15979397
58	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.15683204
59	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.14824514
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14669114
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14669114
62	XRN2_22483619_ChIP-Seq_HELA_Human	1.14276238
63	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.14238142
64	REST_21632747_ChIP-Seq_MESCs_Mouse	1.13640723
65	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13344013
66	P53_21459846_ChIP-Seq_SAOS-2_Human	1.12501583
67	MYC_19829295_ChIP-Seq_ESCs_Human	1.11111430
68	RNF2_27304074_Chip-Seq_NSC_Mouse	1.09601605
69	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.08142519
70	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.08073596
71	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.05554784
72	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.05506479
73	STAT1_20625510_ChIP-Seq_HELA_Human	1.04523925
74	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.03848922
75	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.03846192
76	CBP_20019798_ChIP-Seq_JUKART_Human	1.03778385
77	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.03778385
78	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.03610597
79	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02298441
80	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02298441
81	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.01819262
82	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01162161
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99692264
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.99305193
85	CTCF_20526341_ChIP-Seq_ESCs_Human	0.97041500
86	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.96948017
87	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.96765317
88	E2F1_20622854_ChIP-Seq_HELA_Human	0.96611814
89	GABP_19822575_ChIP-Seq_HepG2_Human	0.96289417
90	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95215835
91	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.95008511
92	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.93610519
93	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.92229926
94	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.91543034
95	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.91201972
96	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.91085734
97	GBX2_23144817_ChIP-Seq_PC3_Human	0.89802879
98	SOX2_21211035_ChIP-Seq_LN229_Human	0.89454487
99	RBPJ_21746931_ChIP-Seq_IB4_Human	0.89398968
100	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.89125393

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.39758060
2	MP0006292_abnormal_olfactory_placode	4.13399182
3	MP0002163_abnormal_gland_morphology	3.32039325
4	MP0003646_muscle_fatigue	2.41895349
5	MP0005646_abnormal_pituitary_gland	2.39345701
6	MP0005671_abnormal_response_to	2.18972772
7	MP0005379_endocrine/exocrine_gland_phen	2.08635784
8	MP0008875_abnormal_xenobiotic_pharmacok	1.98806437
9	MP0003787_abnormal_imprinting	1.94896414
10	MP0005551_abnormal_eye_electrophysiolog	1.93539455
11	MP0006072_abnormal_retinal_apoptosis	1.81217787
12	MP0006276_abnormal_autonomic_nervous	1.80883768
13	MP0008872_abnormal_physiological_respon	1.75743686
14	MP0004142_abnormal_muscle_tone	1.74353291
15	MP0002837_dystrophic_cardiac_calcinosis	1.73338457
16	MP0002638_abnormal_pupillary_reflex	1.72770817
17	MP0002234_abnormal_pharynx_morphology	1.70259171
18	MP0004885_abnormal_endolymph	1.67950034
19	MP0001968_abnormal_touch/_nociception	1.65927431
20	MP0008877_abnormal_DNA_methylation	1.63984718
21	MP0002160_abnormal_reproductive_system	1.61271957
22	MP0002102_abnormal_ear_morphology	1.57884908
23	MP0002736_abnormal_nociception_after	1.54633484
24	MP0005389_reproductive_system_phenotype	1.54075759
25	MP0005084_abnormal_gallbladder_morpholo	1.51982627
26	MP0000372_irregular_coat_pigmentation	1.49961929
27	MP0003136_yellow_coat_color	1.49193474
28	MP0000049_abnormal_middle_ear	1.45286302
29	MP0005360_urolithiasis	1.44239330
30	MP0004145_abnormal_muscle_electrophysio	1.40061179
31	MP0005377_hearing/vestibular/ear_phenot	1.39112963
32	MP0003878_abnormal_ear_physiology	1.39112963
33	MP0005645_abnormal_hypothalamus_physiol	1.38821953
34	MP0002277_abnormal_respiratory_mucosa	1.38107510
35	MP0002272_abnormal_nervous_system	1.36885991
36	MP0003880_abnormal_central_pattern	1.34246183
37	MP0002938_white_spotting	1.32581451
38	MP0000631_abnormal_neuroendocrine_gland	1.31636390
39	MP0001986_abnormal_taste_sensitivity	1.31277859
40	MP0008789_abnormal_olfactory_epithelium	1.29265029
41	MP0001905_abnormal_dopamine_level	1.28981762
42	MP0003122_maternal_imprinting	1.28422275
43	MP0002876_abnormal_thyroid_physiology	1.26763006
44	MP0009745_abnormal_behavioral_response	1.24524666
45	MP0004147_increased_porphyrin_level	1.20357294
46	MP0001919_abnormal_reproductive_system	1.20147036
47	MP0003011_delayed_dark_adaptation	1.17678631
48	MP0002138_abnormal_hepatobiliary_system	1.12720677
49	MP0002733_abnormal_thermal_nociception	1.12549008
50	MP0001873_stomach_inflammation	1.10662377
51	MP0009764_decreased_sensitivity_to	1.10599921
52	MP0001188_hyperpigmentation	1.10073690
53	MP0001970_abnormal_pain_threshold	1.07914999
54	MP0003786_premature_aging	1.06380207
55	MP0002095_abnormal_skin_pigmentation	1.05813778
56	MP0004133_heterotaxia	1.04072532
57	MP0003724_increased_susceptibility_to	1.03784256
58	MP0001835_abnormal_antigen_presentation	1.02688546
59	MP0009046_muscle_twitch	1.02452460
60	MP0003195_calcinosis	1.02384523
61	MP0001485_abnormal_pinna_reflex	1.00323380
62	MP0001293_anophthalmia	0.99940786
63	MP0005195_abnormal_posterior_eye	0.99915478
64	MP0005253_abnormal_eye_physiology	0.99748372
65	MP0008775_abnormal_heart_ventricle	0.97725126
66	MP0001440_abnormal_grooming_behavior	0.94574211
67	MP0002653_abnormal_ependyma_morphology	0.91424034
68	MP0002572_abnormal_emotion/affect_behav	0.90432127
69	MP0002132_abnormal_respiratory_system	0.88830233
70	MP0009785_altered_susceptibility_to	0.87317099
71	MP0001348_abnormal_lacrimal_gland	0.86261937
72	MP0008995_early_reproductive_senescence	0.85839654
73	MP0005332_abnormal_amino_acid	0.85799577
74	MP0003119_abnormal_digestive_system	0.85346188
75	MP0005410_abnormal_fertilization	0.85335561
76	MP0003567_abnormal_fetal_cardiomyocyte	0.83681490
77	MP0005083_abnormal_biliary_tract	0.82644634
78	MP0003121_genomic_imprinting	0.82393865
79	MP0002064_seizures	0.81820054
80	MP0002752_abnormal_somatic_nervous	0.81054151
81	MP0005423_abnormal_somatic_nervous	0.80736871
82	MP0005394_taste/olfaction_phenotype	0.80352017
83	MP0005499_abnormal_olfactory_system	0.80352017
84	MP0003879_abnormal_hair_cell	0.79972830
85	MP0003866_abnormal_defecation	0.79765567
86	MP0004742_abnormal_vestibular_system	0.78874270
87	MP0001663_abnormal_digestive_system	0.78845580
88	MP0002557_abnormal_social/conspecific_i	0.78627569
89	MP0004043_abnormal_pH_regulation	0.76835878
90	MP0005623_abnormal_meninges_morphology	0.76701843
91	MP0001502_abnormal_circadian_rhythm	0.76655517
92	MP0010386_abnormal_urinary_bladder	0.76165003
93	MP0002148_abnormal_hypersensitivity_rea	0.76011048
94	MP0003806_abnormal_nucleotide_metabolis	0.75490708
95	MP0002735_abnormal_chemical_nociception	0.75339327
96	MP0002210_abnormal_sex_determination	0.74727443
97	MP0005167_abnormal_blood-brain_barrier	0.73458438
98	MP0002184_abnormal_innervation	0.72729673
99	MP0003635_abnormal_synaptic_transmissio	0.71680006
100	MP0005187_abnormal_penis_morphology	0.71082280

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	5.13441194
2	Acute necrotizing encephalopathy (HP:0006965)	4.29685547
3	Cerebellar dysplasia (HP:0007033)	4.27300165
4	Hypoplasia of the pons (HP:0012110)	4.14108189
5	Abnormality of cells of the erythroid lineage (HP:0012130)	3.98580489
6	Abnormality of the pons (HP:0007361)	3.96451300
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.77158559
8	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.74825080
9	Acute encephalopathy (HP:0006846)	3.64395517
10	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.62344713
11	Abolished electroretinogram (ERG) (HP:0000550)	3.60303389
12	Mitochondrial inheritance (HP:0001427)	3.58851837
13	Progressive macrocephaly (HP:0004481)	3.51276521
14	Abnormality of midbrain morphology (HP:0002418)	3.50660060
15	Molar tooth sign on MRI (HP:0002419)	3.50660060
16	3-Methylglutaconic aciduria (HP:0003535)	3.50141268
17	Abnormal number of erythroid precursors (HP:0012131)	3.38312544
18	Pancreatic fibrosis (HP:0100732)	3.36819283
19	Increased hepatocellular lipid droplets (HP:0006565)	3.32999893
20	Lipid accumulation in hepatocytes (HP:0006561)	3.29104680
21	Reticulocytopenia (HP:0001896)	3.27996453
22	Pancreatic cysts (HP:0001737)	3.25969012
23	Retinal dysplasia (HP:0007973)	3.23591112
24	Macrocytic anemia (HP:0001972)	3.21203677
25	Increased CSF lactate (HP:0002490)	3.16380697
26	Pallor (HP:0000980)	3.04650576
27	Retinal atrophy (HP:0001105)	2.96314867
28	Congenital stationary night blindness (HP:0007642)	2.84845187
29	Renal Fanconi syndrome (HP:0001994)	2.84586554
30	True hermaphroditism (HP:0010459)	2.80804549
31	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.78713309
32	Hyperglycinemia (HP:0002154)	2.78381056
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.78323048
34	Asplenia (HP:0001746)	2.77883358
35	Nephronophthisis (HP:0000090)	2.73908992
36	Increased intramyocellular lipid droplets (HP:0012240)	2.68792135
37	Cerebral edema (HP:0002181)	2.62286223
38	Lissencephaly (HP:0001339)	2.43805813
39	Optic disc pallor (HP:0000543)	2.39660423
40	Hepatocellular necrosis (HP:0001404)	2.38364588
41	Increased muscle lipid content (HP:0009058)	2.37290703
42	Severe muscular hypotonia (HP:0006829)	2.36454168
43	Abnormality of the renal medulla (HP:0100957)	2.28590267
44	Sclerocornea (HP:0000647)	2.27436810
45	Hepatic necrosis (HP:0002605)	2.26584042
46	Cystic liver disease (HP:0006706)	2.25464493
47	Pachygyria (HP:0001302)	2.24187345
48	Medial flaring of the eyebrow (HP:0010747)	2.24078151
49	Stenosis of the external auditory canal (HP:0000402)	2.23216457
50	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.22969612
51	Polydipsia (HP:0001959)	2.19454286
52	Abnormal drinking behavior (HP:0030082)	2.19454286
53	Anencephaly (HP:0002323)	2.17452046
54	IgG deficiency (HP:0004315)	2.16868994
55	Abnormality of the renal cortex (HP:0011035)	2.15036978
56	Decreased central vision (HP:0007663)	2.13305899
57	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.12814915
58	Pendular nystagmus (HP:0012043)	2.12212670
59	Exertional dyspnea (HP:0002875)	2.11767990
60	Absent thumb (HP:0009777)	2.07935724
61	Congenital, generalized hypertrichosis (HP:0004540)	2.07423585
62	Absent/shortened dynein arms (HP:0200106)	2.05714947
63	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.05714947
64	Lactic acidosis (HP:0003128)	2.05685890
65	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.02014001
66	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.02014001
67	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.01248076
68	Abnormality of DNA repair (HP:0003254)	2.00721351
69	Abnormality of renal resorption (HP:0011038)	1.96017401
70	Glycosuria (HP:0003076)	1.95793885
71	Abnormality of urine glucose concentration (HP:0011016)	1.95793885
72	Elevated erythrocyte sedimentation rate (HP:0003565)	1.93400316
73	Lethargy (HP:0001254)	1.91272220
74	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.90839453
75	Supernumerary spleens (HP:0009799)	1.89698484
76	Increased serum lactate (HP:0002151)	1.89550242
77	Abnormal hemoglobin (HP:0011902)	1.85395896
78	Concave nail (HP:0001598)	1.84528709
79	Respiratory failure (HP:0002878)	1.82862322
80	Tubular atrophy (HP:0000092)	1.82400849
81	Colon cancer (HP:0003003)	1.81798714
82	Increased corneal curvature (HP:0100692)	1.81211013
83	Keratoconus (HP:0000563)	1.81211013
84	Poor suck (HP:0002033)	1.78280658
85	Agitation (HP:0000713)	1.76828311
86	Methylmalonic acidemia (HP:0002912)	1.76389681
87	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.75521461
88	Postaxial foot polydactyly (HP:0001830)	1.73924793
89	Leukodystrophy (HP:0002415)	1.73668660
90	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.72433955
91	Occipital encephalocele (HP:0002085)	1.72385170
92	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.71623525
93	Hip dysplasia (HP:0001385)	1.70350939
94	Aplasia/hypoplasia of the uterus (HP:0008684)	1.68444026
95	Polyuria (HP:0000103)	1.67730225
96	Hypoplasia of the brainstem (HP:0002365)	1.67466331
97	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.67466331
98	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.66105468
99	Abnormality of alanine metabolism (HP:0010916)	1.66105468
100	Hyperalaninemia (HP:0003348)	1.66105468

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	2.96939596
2	BCKDK	2.76471009
3	ADRBK2	2.71412258
4	GRK1	2.67356717
5	TLK1	2.63404730
6	LIMK1	2.56236243
7	WNK4	2.49743481
8	TIE1	2.47805588
9	STK16	2.39226734
10	ZAK	2.31457232
11	TAOK3	2.26457574
12	BMPR1B	1.91132814
13	NME2	1.86589432
14	MAP4K1	1.85862357
15	MARK3	1.84377966
16	FRK	1.83799276
17	PINK1	1.82582432
18	CDK19	1.79797246
19	WNK3	1.77721960
20	DYRK2	1.67873895
21	MAP4K2	1.64735862
22	NUAK1	1.60726898
23	PIK3CA	1.51746406
24	CAMKK2	1.39299691
25	KDR	1.38515542
26	STK10	1.37603142
27	PRKCQ	1.34466571
28	TEC	1.34283954
29	MAP3K4	1.33792409
30	LRRK2	1.18653026
31	MAPK13	1.18187456
32	MAP3K11	1.15497164
33	ITK	1.13229440
34	PRKCG	1.12034235
35	IKBKB	1.09325352
36	MAP2K7	1.08062259
37	INSRR	1.06270871
38	STK11	1.05096287
39	ADRBK1	1.02322505
40	CSF1R	1.00577861
41	PRKCH	0.97598276
42	STK39	0.96913077
43	PIM1	0.95763637
44	RPS6KA5	0.94816736
45	CSNK1G3	0.89666474
46	MAP2K6	0.87494919
47	PASK	0.86979397
48	CSNK1G1	0.85020138
49	MINK1	0.84532426
50	ABL2	0.80878331
51	OBSCN	0.79276264
52	CSNK1G2	0.78360573
53	CSNK2A2	0.76051895
54	OXSR1	0.74767980
55	PHKG2	0.74131707
56	PHKG1	0.74131707
57	MUSK	0.73084268
58	KIT	0.71167715
59	FES	0.71107427
60	EPHA4	0.69676845
61	BTK	0.68629633
62	PRKACA	0.66782321
63	VRK1	0.65490235
64	CASK	0.65086378
65	PLK4	0.63265892
66	CAMK1	0.62908663
67	CSNK1A1	0.61119940
68	LCK	0.60675057
69	CSNK2A1	0.60100186
70	SYK	0.59237105
71	TGFBR1	0.58543107
72	PRKCA	0.55942125
73	VRK2	0.52529222
74	NTRK2	0.52455473
75	NEK1	0.52396277
76	LYN	0.52335761
77	GRK7	0.50859003
78	CAMK2A	0.50290255
79	CSNK1A1L	0.50028823
80	CAMKK1	0.48997338
81	PRKCE	0.48600632
82	RPS6KA6	0.47704159
83	AURKA	0.47178098
84	IGF1R	0.45868819
85	MAPK15	0.45817362
86	PTK2B	0.43732715
87	PAK3	0.43168301
88	TESK1	0.41341594
89	PLK2	0.40257540
90	PIM2	0.39905816
91	CAMK2D	0.39352739
92	MAPKAPK5	0.39024579
93	PRKCD	0.38397786
94	DAPK2	0.38066716
95	PKN1	0.37292826
96	MAP2K2	0.37240559
97	SGK1	0.33216765
98	PRKACG	0.32961721
99	CSNK1E	0.32842682
100	DYRK1A	0.32840620

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.21380653
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.00725262
3	Parkinsons disease_Homo sapiens_hsa05012	3.21664605
4	Sulfur relay system_Homo sapiens_hsa04122	3.11423596
5	Huntingtons disease_Homo sapiens_hsa05016	2.25265178
6	Alzheimers disease_Homo sapiens_hsa05010	2.21564036
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.21284652
8	Asthma_Homo sapiens_hsa05310	2.14443032
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.13711395
10	RNA polymerase_Homo sapiens_hsa03020	2.01885825
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.83174339
12	Graft-versus-host disease_Homo sapiens_hsa05332	1.82854128
13	Allograft rejection_Homo sapiens_hsa05330	1.81919998
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.79719121
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.78635294
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.76131539
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.73035298
18	Phototransduction_Homo sapiens_hsa04744	1.67818209
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.66512171
20	Primary immunodeficiency_Homo sapiens_hsa05340	1.60508283
21	Proteasome_Homo sapiens_hsa03050	1.58662950
22	Protein export_Homo sapiens_hsa03060	1.51673716
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.46636429
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.45125856
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.39162916
26	One carbon pool by folate_Homo sapiens_hsa00670	1.37976087
27	RNA degradation_Homo sapiens_hsa03018	1.31500392
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.25030682
29	Nicotine addiction_Homo sapiens_hsa05033	1.23897267
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.23679756
31	Butanoate metabolism_Homo sapiens_hsa00650	1.18751811
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17748574
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.14620434
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.12966223
35	Sulfur metabolism_Homo sapiens_hsa00920	1.11043624
36	Caffeine metabolism_Homo sapiens_hsa00232	1.10293483
37	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.09234786
38	Peroxisome_Homo sapiens_hsa04146	1.04577254
39	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.03599382
40	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.01015890
41	Propanoate metabolism_Homo sapiens_hsa00640	0.96064296
42	Fat digestion and absorption_Homo sapiens_hsa04975	0.95701711
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.95493833
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.94220228
45	Homologous recombination_Homo sapiens_hsa03440	0.92893311
46	Fanconi anemia pathway_Homo sapiens_hsa03460	0.92544410
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87182041
48	Antigen processing and presentation_Homo sapiens_hsa04612	0.86224426
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.85804732
50	Purine metabolism_Homo sapiens_hsa00230	0.84936257
51	Olfactory transduction_Homo sapiens_hsa04740	0.84090952
52	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.81062862
53	Ether lipid metabolism_Homo sapiens_hsa00565	0.80448692
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79691926
55	Nucleotide excision repair_Homo sapiens_hsa03420	0.76703837
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76462647
57	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76300869
58	Retinol metabolism_Homo sapiens_hsa00830	0.75859206
59	Rheumatoid arthritis_Homo sapiens_hsa05323	0.74069755
60	Metabolic pathways_Homo sapiens_hsa01100	0.72427240
61	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71503647
62	Basal transcription factors_Homo sapiens_hsa03022	0.69675855
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.69088686
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68489821
65	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.66647066
66	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.66632207
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66575379
68	DNA replication_Homo sapiens_hsa03030	0.62666288
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62213251
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60020358
71	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.59396643
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.59009893
73	Taste transduction_Homo sapiens_hsa04742	0.58363783
74	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.50503870
75	Morphine addiction_Homo sapiens_hsa05032	0.50374319
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50252573
77	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.49860741
78	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.49748247
79	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.48291275
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.47158978
81	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.46813995
82	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.45715840
83	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.44267566
84	Mismatch repair_Homo sapiens_hsa03430	0.43117396
85	Insulin secretion_Homo sapiens_hsa04911	0.40581058
86	Regulation of autophagy_Homo sapiens_hsa04140	0.40515593
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38992508
88	Serotonergic synapse_Homo sapiens_hsa04726	0.37852526
89	Base excision repair_Homo sapiens_hsa03410	0.37664561
90	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.37512917
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36578159
92	RNA transport_Homo sapiens_hsa03013	0.34064067
93	Salivary secretion_Homo sapiens_hsa04970	0.31758031
94	GABAergic synapse_Homo sapiens_hsa04727	0.28625034
95	Spliceosome_Homo sapiens_hsa03040	0.28561199
96	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.27900277
97	Fatty acid degradation_Homo sapiens_hsa00071	0.27519759
98	Arginine and proline metabolism_Homo sapiens_hsa00330	0.25452466
99	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.22485285
100	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.21914455

RPL31P49

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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