RPL31P50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.25310410
2viral transcription (GO:0019083)7.24611074
3translational termination (GO:0006415)6.94618643
4energy coupled proton transport, down electrochemical gradient (GO:0015985)6.87859276
5ATP synthesis coupled proton transport (GO:0015986)6.87859276
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.54632404
7cotranslational protein targeting to membrane (GO:0006613)6.42098414
8protein targeting to ER (GO:0045047)6.37171047
9protein localization to endoplasmic reticulum (GO:0070972)6.11531766
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.10354758
11translational elongation (GO:0006414)5.84484332
12ribosomal small subunit assembly (GO:0000028)5.82915153
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.70928847
14ribosomal large subunit biogenesis (GO:0042273)5.69914064
15viral life cycle (GO:0019058)5.20723145
16cellular protein complex disassembly (GO:0043624)5.17168712
17respiratory electron transport chain (GO:0022904)5.00547958
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.96708004
19electron transport chain (GO:0022900)4.90710521
20translational initiation (GO:0006413)4.79425338
21ribosomal small subunit biogenesis (GO:0042274)4.67862156
22protein targeting to membrane (GO:0006612)4.51894511
23RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.47878172
24tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.47878172
25protein complex biogenesis (GO:0070271)4.40040699
26mitochondrial respiratory chain complex I assembly (GO:0032981)4.34649914
27NADH dehydrogenase complex assembly (GO:0010257)4.34649914
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.34649914
29protein complex disassembly (GO:0043241)4.22478610
30regulation of hypersensitivity (GO:0002883)4.18749906
31maturation of SSU-rRNA (GO:0030490)4.16511417
32translation (GO:0006412)4.14737542
33macromolecular complex disassembly (GO:0032984)4.06777733
34aldehyde catabolic process (GO:0046185)3.94395232
35mitochondrial respiratory chain complex assembly (GO:0033108)3.89278762
36ATP biosynthetic process (GO:0006754)3.80766669
37regulation of cellular respiration (GO:0043457)3.78391338
38nuclear-transcribed mRNA catabolic process (GO:0000956)3.67778598
39oxidative phosphorylation (GO:0006119)3.65028032
40positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.63199964
41proteasome assembly (GO:0043248)3.59723433
42chaperone-mediated protein transport (GO:0072321)3.59447863
43regulation of oxidative phosphorylation (GO:0002082)3.54037143
44purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.51581530
45purine nucleoside triphosphate biosynthetic process (GO:0009145)3.49868704
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.49631917
47GPI anchor biosynthetic process (GO:0006506)3.47269162
48mRNA catabolic process (GO:0006402)3.42936099
49negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.39022074
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.37641034
51termination of RNA polymerase III transcription (GO:0006386)3.37641034
52spliceosomal complex assembly (GO:0000245)3.33389987
53regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.28488958
54hydrogen ion transmembrane transport (GO:1902600)3.28124105
55positive regulation of mast cell degranulation (GO:0043306)3.27417365
56positive regulation of mast cell activation involved in immune response (GO:0033008)3.27417365
57GPI anchor metabolic process (GO:0006505)3.16688802
58proton transport (GO:0015992)3.16051519
59RNA catabolic process (GO:0006401)3.13350211
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13011890
61hydrogen transport (GO:0006818)3.12307565
62establishment of protein localization to membrane (GO:0090150)3.07666992
63positive regulation of mast cell activation (GO:0033005)3.03332776
64preassembly of GPI anchor in ER membrane (GO:0016254)3.02203357
65positive regulation of protein homodimerization activity (GO:0090073)2.99854502
66ribonucleoside triphosphate biosynthetic process (GO:0009201)2.98636679
67cellular component biogenesis (GO:0044085)2.98349230
68protein neddylation (GO:0045116)2.96958879
69positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.95405636
70mast cell activation (GO:0045576)2.91591215
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90119000
72DNA deamination (GO:0045006)2.88760109
73platelet dense granule organization (GO:0060155)2.88304853
74mannosylation (GO:0097502)2.87944621
75protein targeting (GO:0006605)2.86499137
76regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.85970408
77regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.79127614
78negative regulation of heart rate (GO:0010459)2.77079068
79positive regulation of interleukin-17 production (GO:0032740)2.75182004
80regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.72951345
81viral protein processing (GO:0019082)2.69228968
82anterograde synaptic vesicle transport (GO:0048490)2.67660607
83dopamine transport (GO:0015872)2.66637839
84innate immune response in mucosa (GO:0002227)2.66549154
85regulation of cilium movement (GO:0003352)2.65520623
86behavioral response to nicotine (GO:0035095)2.60459896
87GTP biosynthetic process (GO:0006183)2.59161924
88ribonucleoprotein complex biogenesis (GO:0022613)2.57399717
89detection of molecule of bacterial origin (GO:0032490)2.56277413
90nucleoside triphosphate biosynthetic process (GO:0009142)2.53658001
91negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.51735840
92establishment of protein localization to organelle (GO:0072594)2.45764149
93leukotriene biosynthetic process (GO:0019370)2.43422992
94protein localization to membrane (GO:0072657)2.42199530
95epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.41805234
96regulation of germinal center formation (GO:0002634)2.41228888
97immunoglobulin mediated immune response (GO:0016064)2.38295198
98interferon-gamma-mediated signaling pathway (GO:0060333)2.36612089
99positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.33639256
100T cell costimulation (GO:0031295)2.32718085

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.13174561
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.08662166
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16966659
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.12922868
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.93925719
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.89001776
7VDR_22108803_ChIP-Seq_LS180_Human2.81282843
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.60329567
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.56103255
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54309097
11ZNF274_21170338_ChIP-Seq_K562_Hela2.43733811
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.32565687
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.30687845
14VDR_23849224_ChIP-Seq_CD4+_Human2.27799096
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.17810695
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.09775398
17IRF8_21731497_ChIP-ChIP_J774_Mouse1.99449094
18TAF15_26573619_Chip-Seq_HEK293_Human1.99305542
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84367848
20ELK1_19687146_ChIP-ChIP_HELA_Human1.82241930
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80441126
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.78509164
23FOXP3_21729870_ChIP-Seq_TREG_Human1.76202786
24GATA3_26560356_Chip-Seq_TH2_Human1.71308414
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67816912
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66105779
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58997093
28AR_20517297_ChIP-Seq_VCAP_Human1.57826579
29EZH2_22144423_ChIP-Seq_EOC_Human1.56718021
30TTF2_22483619_ChIP-Seq_HELA_Human1.55604279
31TP53_22573176_ChIP-Seq_HFKS_Human1.46300534
32EWS_26573619_Chip-Seq_HEK293_Human1.45200879
33FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44516106
34FOXA1_25329375_ChIP-Seq_VCAP_Human1.44516106
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42731815
36ER_23166858_ChIP-Seq_MCF-7_Human1.40944857
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40760639
38NANOG_19829295_ChIP-Seq_ESCs_Human1.38952513
39SOX2_19829295_ChIP-Seq_ESCs_Human1.38952513
40TDRD3_21172665_ChIP-Seq_MCF-7_Human1.37869084
41IRF1_19129219_ChIP-ChIP_H3396_Human1.34985893
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33549554
43GATA3_21878914_ChIP-Seq_MCF-7_Human1.32226425
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31798223
45FUS_26573619_Chip-Seq_HEK293_Human1.29999866
46P300_19829295_ChIP-Seq_ESCs_Human1.28109188
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28079691
48SPI1_23547873_ChIP-Seq_NB4_Human1.25602387
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22601510
50FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22279166
51ERG_20517297_ChIP-Seq_VCAP_Human1.21236245
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20799508
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20147047
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19768646
55FOXH1_21741376_ChIP-Seq_EPCs_Human1.19060205
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18218233
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17716445
58IGF1R_20145208_ChIP-Seq_DFB_Human1.17039561
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16825029
60CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15101531
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15091263
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15089703
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15082194
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13675005
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13048908
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.12248137
67MYC_18940864_ChIP-ChIP_HL60_Human1.11825787
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11305239
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.10017538
70TAF2_19829295_ChIP-Seq_ESCs_Human1.09969540
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07926420
72PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06313419
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05786020
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.03037455
75ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01550609
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01307355
77CIITA_25753668_ChIP-Seq_RAJI_Human0.99964271
78EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99443134
79EED_16625203_ChIP-ChIP_MESCs_Mouse0.98175223
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97459461
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97240100
82TCF4_22108803_ChIP-Seq_LS180_Human0.96871186
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96206005
84MYC_19829295_ChIP-Seq_ESCs_Human0.95633618
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94686644
86BCL6_27268052_Chip-Seq_Bcells_Human0.94406413
87GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92631147
88RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92189495
89E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91540186
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91340917
91CRX_20693478_ChIP-Seq_RETINA_Mouse0.90568401
92NCOR_22424771_ChIP-Seq_293T_Human0.90263100
93CBP_20019798_ChIP-Seq_JUKART_Human0.90238784
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90238784
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90021774
96NANOG_20526341_ChIP-Seq_ESCs_Human0.89484098
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89307365
98GATA6_21074721_ChIP-Seq_CACO-2_Human0.89276696
99EZH2_27294783_Chip-Seq_NPCs_Mouse0.88502764
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88283868

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.18820602
2MP0001835_abnormal_antigen_presentation4.95530471
3MP0003806_abnormal_nucleotide_metabolis4.20741781
4MP0004142_abnormal_muscle_tone3.20458694
5MP0005671_abnormal_response_to3.06626495
6MP0006292_abnormal_olfactory_placode2.70819194
7MP0004147_increased_porphyrin_level2.65343489
8MP0000372_irregular_coat_pigmentation2.56342594
9MP0004145_abnormal_muscle_electrophysio2.49932257
10MP0003186_abnormal_redox_activity2.39306990
11MP0003724_increased_susceptibility_to2.24670077
12MP0008872_abnormal_physiological_respon2.10682814
13MP0001800_abnormal_humoral_immune1.87720467
14MP0001986_abnormal_taste_sensitivity1.86075630
15MP0002166_altered_tumor_susceptibility1.82797664
16MP0001529_abnormal_vocalization1.81198043
17MP0009785_altered_susceptibility_to1.80007085
18MP0006072_abnormal_retinal_apoptosis1.79418366
19MP0001905_abnormal_dopamine_level1.75214927
20MP0008789_abnormal_olfactory_epithelium1.71964163
21MP0002163_abnormal_gland_morphology1.70088471
22MP0002148_abnormal_hypersensitivity_rea1.62795717
23MP0003195_calcinosis1.62062634
24MP0002452_abnormal_antigen_presenting1.59939859
25MP0002837_dystrophic_cardiac_calcinosis1.59681929
26MP0001968_abnormal_touch/_nociception1.58809614
27MP0006036_abnormal_mitochondrial_physio1.57124445
28MP0005084_abnormal_gallbladder_morpholo1.56435685
29MP0009697_abnormal_copulation1.54997104
30MP0005000_abnormal_immune_tolerance1.46920982
31MP0002006_tumorigenesis1.46841237
32MP0000685_abnormal_immune_system1.46646753
33MP0005367_renal/urinary_system_phenotyp1.45686161
34MP0000516_abnormal_urinary_system1.45686161
35MP0008875_abnormal_xenobiotic_pharmacok1.45400108
36MP0003880_abnormal_central_pattern1.43002560
37MP0008995_early_reproductive_senescence1.41461250
38MP0002723_abnormal_immune_serum1.40282553
39MP0009764_decreased_sensitivity_to1.39605825
40MP0002102_abnormal_ear_morphology1.38057201
41MP0002234_abnormal_pharynx_morphology1.37073084
42MP0005551_abnormal_eye_electrophysiolog1.33807866
43MP0001919_abnormal_reproductive_system1.29814868
44MP0001440_abnormal_grooming_behavior1.28018901
45MP0005075_abnormal_melanosome_morpholog1.25106678
46MP0001819_abnormal_immune_cell1.22916973
47MP0005394_taste/olfaction_phenotype1.21057396
48MP0005499_abnormal_olfactory_system1.21057396
49MP0005389_reproductive_system_phenotype1.19156306
50MP0002420_abnormal_adaptive_immunity1.17680884
51MP0010386_abnormal_urinary_bladder1.17017069
52MP0009333_abnormal_splenocyte_physiolog1.16331702
53MP0005645_abnormal_hypothalamus_physiol1.11161822
54MP0002095_abnormal_skin_pigmentation1.10598482
55MP0005025_abnormal_response_to1.10459859
56MP0006035_abnormal_mitochondrial_morpho1.09233966
57MP0004885_abnormal_endolymph1.06725183
58MP0005646_abnormal_pituitary_gland1.06425582
59MP0002736_abnormal_nociception_after1.05923739
60MP0001970_abnormal_pain_threshold1.04926302
61MP0001485_abnormal_pinna_reflex1.04457830
62MP0001790_abnormal_immune_system1.03799680
63MP0005387_immune_system_phenotype1.03799680
64MP0002419_abnormal_innate_immunity1.02129168
65MP0001486_abnormal_startle_reflex0.99265962
66MP0006276_abnormal_autonomic_nervous0.98850189
67MP0002272_abnormal_nervous_system0.96367627
68MP0003787_abnormal_imprinting0.93795308
69MP0006082_CNS_inflammation0.91156070
70MP0005636_abnormal_mineral_homeostasis0.90757052
71MP0003786_premature_aging0.90057226
72MP0001984_abnormal_olfaction0.89013636
73MP0000716_abnormal_immune_system0.85298796
74MP0009745_abnormal_behavioral_response0.84455367
75MP0005379_endocrine/exocrine_gland_phen0.83402545
76MP0005253_abnormal_eye_physiology0.83328148
77MP0003866_abnormal_defecation0.82290074
78MP0003878_abnormal_ear_physiology0.82260640
79MP0005377_hearing/vestibular/ear_phenot0.82260640
80MP0005332_abnormal_amino_acid0.81272809
81MP0001845_abnormal_inflammatory_respons0.80831652
82MP0002735_abnormal_chemical_nociception0.77712322
83MP0003436_decreased_susceptibility_to0.76507149
84MP0008877_abnormal_DNA_methylation0.76078226
85MP0001764_abnormal_homeostasis0.75895673
86MP0001765_abnormal_ion_homeostasis0.75734874
87MP0003646_muscle_fatigue0.75140094
88MP0002398_abnormal_bone_marrow0.73315084
89MP0005167_abnormal_blood-brain_barrier0.69398406
90MP0001756_abnormal_urination0.69306675
91MP0002822_catalepsy0.68977550
92MP0003638_abnormal_response/metabolism_0.66936036
93MP0008469_abnormal_protein_level0.65211112
94MP0000230_abnormal_systemic_arterial0.65157285
95MP0002429_abnormal_blood_cell0.64493240
96MP0003137_abnormal_impulse_conducting0.63970954
97MP0008873_increased_physiological_sensi0.63024623
98MP0005408_hypopigmentation0.60466859
99MP0002653_abnormal_ependyma_morphology0.60459922
100MP0001963_abnormal_hearing_physiology0.60206883

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.27248631
2Mitochondrial inheritance (HP:0001427)4.93403840
3Hepatocellular necrosis (HP:0001404)4.72315145
4Abnormal mitochondria in muscle tissue (HP:0008316)4.71927844
5Congenital, generalized hypertrichosis (HP:0004540)4.54561677
6Increased CSF lactate (HP:0002490)4.33780288
7Progressive macrocephaly (HP:0004481)4.33537309
8Acute encephalopathy (HP:0006846)4.24641348
93-Methylglutaconic aciduria (HP:0003535)4.23845551
10Reticulocytopenia (HP:0001896)4.06861322
11Increased hepatocellular lipid droplets (HP:0006565)4.06419399
12Lipid accumulation in hepatocytes (HP:0006561)4.04918304
13Hepatic necrosis (HP:0002605)3.70602080
14Abnormality of cells of the erythroid lineage (HP:0012130)3.67283574
15Renal Fanconi syndrome (HP:0001994)3.46499591
16Exertional dyspnea (HP:0002875)3.41073272
17Increased intramyocellular lipid droplets (HP:0012240)3.39256133
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.34233320
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.34233320
20Macrocytic anemia (HP:0001972)3.31763606
21Cerebral edema (HP:0002181)3.18266834
22Pallor (HP:0000980)3.06846880
23Increased muscle lipid content (HP:0009058)3.06049215
24Elevated erythrocyte sedimentation rate (HP:0003565)2.91665196
25Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.87265100
26IgG deficiency (HP:0004315)2.79307666
27Woolly hair (HP:0002224)2.72706445
28Split foot (HP:0001839)2.69669050
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.64495347
30Abnormal number of erythroid precursors (HP:0012131)2.63850040
31Abnormality of the prostate (HP:0008775)2.61801090
32Fibular aplasia (HP:0002990)2.56417361
33Stenosis of the external auditory canal (HP:0000402)2.55498697
34Leukodystrophy (HP:0002415)2.55138408
35Respiratory failure (HP:0002878)2.46927768
36Hypoproteinemia (HP:0003075)2.46045716
37Concave nail (HP:0001598)2.44439727
38Increased serum lactate (HP:0002151)2.43945098
39Hypothermia (HP:0002045)2.42779678
40Abnormal hemoglobin (HP:0011902)2.42751033
41Lactic acidosis (HP:0003128)2.39200759
42Absent/shortened dynein arms (HP:0200106)2.34999694
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.34999694
44Optic disc pallor (HP:0000543)2.33989887
45B lymphocytopenia (HP:0010976)2.20524600
46Type I transferrin isoform profile (HP:0003642)2.15870499
47Abnormality of midbrain morphology (HP:0002418)2.08249038
48Molar tooth sign on MRI (HP:0002419)2.08249038
49Obstructive lung disease (HP:0006536)2.07998880
50Chronic obstructive pulmonary disease (HP:0006510)2.07998880
51CNS demyelination (HP:0007305)2.06577245
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04781485
53Aplasia/Hypoplasia of the ulna (HP:0006495)2.03263832
54Absent thumb (HP:0009777)2.03088809
55Type II lissencephaly (HP:0007260)2.01521994
56Panhypogammaglobulinemia (HP:0003139)2.01457104
57Abnormality of B cell number (HP:0010975)2.00196523
58Abnormality of DNA repair (HP:0003254)1.99527571
59Exercise intolerance (HP:0003546)1.98438538
60Pancreatic cysts (HP:0001737)1.98416799
61Pulmonary infiltrates (HP:0002113)1.98377205
62Aplastic anemia (HP:0001915)1.97606355
63Aplasia/hypoplasia of the uterus (HP:0008684)1.97138591
64Myokymia (HP:0002411)1.96680386
65Spastic paraparesis (HP:0002313)1.96451733
66Abnormality of renal resorption (HP:0011038)1.95997245
67Hemoptysis (HP:0002105)1.95167533
68Respiratory difficulties (HP:0002880)1.95057311
69Cerebral palsy (HP:0100021)1.94036028
70Medial flaring of the eyebrow (HP:0010747)1.93502130
71Abnormality of the pleura (HP:0002103)1.93456354
72Multiple enchondromatosis (HP:0005701)1.92933127
73Abolished electroretinogram (ERG) (HP:0000550)1.92285803
74Cleft eyelid (HP:0000625)1.91019086
75Triphalangeal thumb (HP:0001199)1.90233289
76Synostosis involving the elbow (HP:0003938)1.89503720
77Humeroradial synostosis (HP:0003041)1.89503720
78Lethargy (HP:0001254)1.87578729
79Radial bowing (HP:0002986)1.86252699
80Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85974667
81Hypoplasia of the ulna (HP:0003022)1.85782637
82Abnormality of urine glucose concentration (HP:0011016)1.83334691
83Glycosuria (HP:0003076)1.83334691
84Congenital ichthyosiform erythroderma (HP:0007431)1.82020711
85Severe combined immunodeficiency (HP:0004430)1.79421395
86Abnormal finger flexion creases (HP:0006143)1.77227550
87Hyperphosphaturia (HP:0003109)1.76625757
88Porencephaly (HP:0002132)1.76577387
89Microvesicular hepatic steatosis (HP:0001414)1.76076830
90Azoospermia (HP:0000027)1.75194329
91X-linked dominant inheritance (HP:0001423)1.71675224
92Abnormal respiratory epithelium morphology (HP:0012253)1.71469903
93Abnormal respiratory motile cilium morphology (HP:0005938)1.71469903
94Methylmalonic acidemia (HP:0002912)1.71102106
95Alveolar cell carcinoma (HP:0006519)1.70245440
96Absent rod-and cone-mediated responses on ERG (HP:0007688)1.68512844
97Nephrogenic diabetes insipidus (HP:0009806)1.65470111
98Congenital primary aphakia (HP:0007707)1.65103070
99Reduced antithrombin III activity (HP:0001976)1.62391433
100Type 2 muscle fiber atrophy (HP:0003554)1.60889166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K125.76475094
2BMPR23.92623729
3MYLK3.52940944
4TLK13.17921228
5CDK192.58207277
6ILK2.40080373
7MAP4K22.35952647
8SCYL22.34270587
9ZAK2.11253880
10GRK11.93901056
11DAPK31.93711666
12NUAK11.87314515
13TXK1.84453802
14TAOK31.66270724
15ADRBK21.58393947
16MST41.51538022
17IKBKB1.45993805
18FLT31.45021874
19TEC1.44148493
20STK161.41270860
21KIT1.41217655
22VRK21.32356662
23INSRR1.29260238
24CSF1R1.28453309
25DAPK11.25570581
26BTK1.24519555
27MAP4K11.22202411
28FES1.22141211
29MUSK1.16717766
30FRK1.11650580
31SYK1.11145828
32PIK3CG1.08524176
33EIF2AK31.08118673
34LYN1.06874092
35LIMK11.04775088
36CDK81.03347594
37CCNB11.00893740
38ERBB31.00547338
39WNK40.99930739
40TIE10.98188078
41EIF2AK20.97638313
42AURKB0.97180582
43ITK0.96358521
44DYRK20.93249574
45PKN10.92316863
46NME20.87618715
47GRK70.84940273
48OBSCN0.84101553
49KDR0.83868935
50OXSR10.81509178
51CAMKK20.79981623
52TRIM280.79754522
53ERBB20.79609839
54GRK60.76721024
55TRPM70.75660441
56TNK20.75246368
57JAK10.73407205
58WNK30.69692722
59GRK50.67388768
60ROCK10.67379246
61MAP3K130.67327741
62MATK0.64940622
63EPHA40.61866912
64LRRK20.59298779
65RPS6KA50.59248150
66PAK40.59149481
67CSNK2A20.58426470
68PINK10.58395667
69ATR0.57842210
70PRKCE0.57237829
71ZAP700.57191736
72IGF1R0.53769753
73PHKG20.53239537
74PHKG10.53239537
75EIF2AK10.52202396
76SRPK10.51451872
77ROCK20.50618505
78EGFR0.50238468
79PIK3CA0.50027849
80ABL10.49440387
81LCK0.49381177
82CSNK2A10.46955792
83RPS6KB20.46239248
84PRKACA0.45757154
85PRKCQ0.45756687
86STK390.45359907
87ADRBK10.43193022
88BLK0.43069697
89PRKCD0.42649520
90TBK10.37976827
91PIM10.37454931
92CAMK2D0.37229498
93PDK20.37146584
94PRKCA0.37079550
95CAMK10.36969522
96NEK10.36055254
97BCKDK0.35968399
98HCK0.35514197
99PRKG10.35342541
100PRKD30.34600432

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.30428567
2Ribosome_Homo sapiens_hsa030104.53338392
3Oxidative phosphorylation_Homo sapiens_hsa001904.07557113
4Allograft rejection_Homo sapiens_hsa053303.81449591
5Graft-versus-host disease_Homo sapiens_hsa053323.72777684
6Autoimmune thyroid disease_Homo sapiens_hsa053203.67462239
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.52966012
8Parkinsons disease_Homo sapiens_hsa050123.40426374
9Type I diabetes mellitus_Homo sapiens_hsa049403.07770606
10Protein export_Homo sapiens_hsa030603.01258051
11Alzheimers disease_Homo sapiens_hsa050102.34427073
12Proteasome_Homo sapiens_hsa030502.28435815
13Huntingtons disease_Homo sapiens_hsa050162.19941868
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19065699
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.11898302
16Cardiac muscle contraction_Homo sapiens_hsa042601.94883055
17Staphylococcus aureus infection_Homo sapiens_hsa051501.78060875
18Rheumatoid arthritis_Homo sapiens_hsa053231.77766577
19Viral myocarditis_Homo sapiens_hsa054161.76433232
20RNA polymerase_Homo sapiens_hsa030201.73768718
21Antigen processing and presentation_Homo sapiens_hsa046121.72018299
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43549667
23Leishmaniasis_Homo sapiens_hsa051401.43480566
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43056390
25Homologous recombination_Homo sapiens_hsa034401.38787039
26Systemic lupus erythematosus_Homo sapiens_hsa053220.95822894
27Nucleotide excision repair_Homo sapiens_hsa034200.95687887
28Regulation of autophagy_Homo sapiens_hsa041400.92026983
29Linoleic acid metabolism_Homo sapiens_hsa005910.92024543
30RNA degradation_Homo sapiens_hsa030180.88104640
31Primary immunodeficiency_Homo sapiens_hsa053400.83468194
32Fanconi anemia pathway_Homo sapiens_hsa034600.80088127
33Basal transcription factors_Homo sapiens_hsa030220.77890313
34Phototransduction_Homo sapiens_hsa047440.77724575
35Hematopoietic cell lineage_Homo sapiens_hsa046400.68815458
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66902875
37Toxoplasmosis_Homo sapiens_hsa051450.66694191
38Drug metabolism - other enzymes_Homo sapiens_hsa009830.64073245
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62854751
40Collecting duct acid secretion_Homo sapiens_hsa049660.61161515
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61132215
42Olfactory transduction_Homo sapiens_hsa047400.59798836
43Pyrimidine metabolism_Homo sapiens_hsa002400.57301951
44Phagosome_Homo sapiens_hsa041450.56776705
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55688061
46Tuberculosis_Homo sapiens_hsa051520.54787521
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53545007
48Chemical carcinogenesis_Homo sapiens_hsa052040.52266949
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49071876
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48955807
51Caffeine metabolism_Homo sapiens_hsa002320.46941064
52Spliceosome_Homo sapiens_hsa030400.45297260
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43192326
54Herpes simplex infection_Homo sapiens_hsa051680.42722607
55Arachidonic acid metabolism_Homo sapiens_hsa005900.42498408
56Mismatch repair_Homo sapiens_hsa034300.42064214
57Epstein-Barr virus infection_Homo sapiens_hsa051690.41318618
58Base excision repair_Homo sapiens_hsa034100.40365167
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.39401955
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38852814
61Influenza A_Homo sapiens_hsa051640.37469342
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37298078
63Peroxisome_Homo sapiens_hsa041460.35745580
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.35146072
65Metabolic pathways_Homo sapiens_hsa011000.32975158
66Propanoate metabolism_Homo sapiens_hsa006400.32253607
67Purine metabolism_Homo sapiens_hsa002300.31798157
68DNA replication_Homo sapiens_hsa030300.31197117
69One carbon pool by folate_Homo sapiens_hsa006700.30288675
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.30243552
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29803150
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29464760
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29316848
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28003608
75Tryptophan metabolism_Homo sapiens_hsa003800.27303123
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26119708
77Nicotine addiction_Homo sapiens_hsa050330.24607672
78Pertussis_Homo sapiens_hsa051330.24476065
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23494728
80Salmonella infection_Homo sapiens_hsa051320.22092410
81African trypanosomiasis_Homo sapiens_hsa051430.21935011
82Retinol metabolism_Homo sapiens_hsa008300.21677862
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21647748
84Morphine addiction_Homo sapiens_hsa050320.21625639
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21044013
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.20842331
87Fatty acid elongation_Homo sapiens_hsa000620.19215706
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.18173677
89RNA transport_Homo sapiens_hsa030130.18131498
90Salivary secretion_Homo sapiens_hsa049700.17720034
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.17665398
92Folate biosynthesis_Homo sapiens_hsa007900.17585340
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.16876017
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15188520
95Fat digestion and absorption_Homo sapiens_hsa049750.12012160
96Glutathione metabolism_Homo sapiens_hsa004800.10655701
97GABAergic synapse_Homo sapiens_hsa047270.10000552
98Tyrosine metabolism_Homo sapiens_hsa003500.07870068
99Circadian entrainment_Homo sapiens_hsa047130.06815321
100Starch and sucrose metabolism_Homo sapiens_hsa005000.06711336

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