RPL31P52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1growth hormone receptor signaling pathway (GO:0060396)7.77828065
2regulation of beta-amyloid formation (GO:1902003)7.24791235
3RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)6.96506652
4positive regulation of cellular amide metabolic process (GO:0034250)6.92964779
5cellular response to growth hormone stimulus (GO:0071378)6.88570656
6SMAD protein complex assembly (GO:0007183)6.74612189
7response to pheromone (GO:0019236)6.62121500
8protein K6-linked ubiquitination (GO:0085020)6.14055297
9cell fate commitment involved in formation of primary germ layer (GO:0060795)5.62834946
10water-soluble vitamin biosynthetic process (GO:0042364)5.52935712
11regulation of amyloid precursor protein catabolic process (GO:1902991)5.44102622
12acrosome reaction (GO:0007340)5.01173156
13negative regulation of JAK-STAT cascade (GO:0046426)4.47979469
14hypothalamus development (GO:0021854)4.44528381
15DNA replication checkpoint (GO:0000076)4.43227823
16regulation of female receptivity (GO:0045924)4.35745089
17regulation of cellular amide metabolic process (GO:0034248)4.33748993
18negative regulation of mast cell activation (GO:0033004)4.23040981
19cellular response to BMP stimulus (GO:0071773)4.11967218
20response to BMP (GO:0071772)4.11967218
21female mating behavior (GO:0060180)4.08249778
22DNA integration (GO:0015074)4.00553960
23histone H2A acetylation (GO:0043968)3.92323485
24kinetochore assembly (GO:0051382)3.91582623
25positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.91565567
26mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.91565567
27hindbrain development (GO:0030902)3.91526983
28regulation of transforming growth factor beta2 production (GO:0032909)3.87294216
29GTP biosynthetic process (GO:0006183)3.80130508
30response to growth hormone (GO:0060416)3.74852689
31attachment of spindle microtubules to kinetochore (GO:0008608)3.74832661
32kinetochore organization (GO:0051383)3.73178987
33DNA double-strand break processing (GO:0000729)3.70874192
34intra-S DNA damage checkpoint (GO:0031573)3.56216455
35aggressive behavior (GO:0002118)3.52156014
36DNA catabolic process, exonucleolytic (GO:0000738)3.51268112
37aldehyde catabolic process (GO:0046185)3.49204495
38kynurenine metabolic process (GO:0070189)3.40711565
39CTP biosynthetic process (GO:0006241)3.40128127
40CTP metabolic process (GO:0046036)3.40128127
41pentose-phosphate shunt (GO:0006098)3.37600091
42NADPH regeneration (GO:0006740)3.36458697
43mismatch repair (GO:0006298)3.35378779
44cardiac muscle cell proliferation (GO:0060038)3.30748486
45neuronal action potential propagation (GO:0019227)3.22274812
46production of molecular mediator of immune response (GO:0002440)3.16260125
47pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.15512146
48Sertoli cell development (GO:0060009)3.14094849
49UTP biosynthetic process (GO:0006228)3.10976428
50production of molecular mediator involved in inflammatory response (GO:0002532)3.09178265
51negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.08128413
52mast cell degranulation (GO:0043303)3.02311062
53mast cell activation involved in immune response (GO:0002279)3.02311062
54retinal cone cell development (GO:0046549)2.98779252
55ncRNA 3-end processing (GO:0043628)2.97864435
56response to interferon-beta (GO:0035456)2.97414194
57L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.96071488
58tryptophan metabolic process (GO:0006568)2.95228159
59regulation of mRNA 3-end processing (GO:0031440)2.93197323
60pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.92405868
61viral mRNA export from host cell nucleus (GO:0046784)2.91576984
62regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.91160056
63positive regulation of organelle assembly (GO:1902117)2.88751467
64nuclear pore organization (GO:0006999)2.88342484
65nucleoside diphosphate phosphorylation (GO:0006165)2.82566458
66UTP metabolic process (GO:0046051)2.81289178
67spliceosomal complex assembly (GO:0000245)2.79468976
68negative regulation of cAMP-mediated signaling (GO:0043951)2.77687637
69nucleotide phosphorylation (GO:0046939)2.75983784
70L-ascorbic acid metabolic process (GO:0019852)2.75468811
71RNA phosphodiester bond hydrolysis (GO:0090501)2.75169019
72striated muscle cell proliferation (GO:0014855)2.73988321
73behavioral response to ethanol (GO:0048149)2.72788999
74pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.71508450
75cellular biogenic amine catabolic process (GO:0042402)2.71403757
76amine catabolic process (GO:0009310)2.71403757
77piRNA metabolic process (GO:0034587)2.70796299
78positive regulation of mitochondrial membrane permeability (GO:0035794)2.69335151
79pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.69218069
80indolalkylamine metabolic process (GO:0006586)2.68077600
81axoneme assembly (GO:0035082)2.62588828
82positive regulation of dendrite morphogenesis (GO:0050775)2.59373613
83indole-containing compound catabolic process (GO:0042436)2.58434384
84indolalkylamine catabolic process (GO:0046218)2.58434384
85tryptophan catabolic process (GO:0006569)2.58434384
86cytokine production involved in immune response (GO:0002367)2.56929143
87response to xenobiotic stimulus (GO:0009410)2.54149122
88face development (GO:0060324)2.54101860
89glucose catabolic process (GO:0006007)2.53737341
90regulation of timing of cell differentiation (GO:0048505)2.53212364
91transcription elongation from RNA polymerase III promoter (GO:0006385)2.53187055
92termination of RNA polymerase III transcription (GO:0006386)2.53187055
93multicellular organism reproduction (GO:0032504)2.52918167
94pseudouridine synthesis (GO:0001522)2.52274951
95positive regulation of cell cycle G1/S phase transition (GO:1902808)2.51858973
96regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.50572498
97DNA deamination (GO:0045006)2.50032010
98vitamin biosynthetic process (GO:0009110)2.46656942
99muscle cell proliferation (GO:0033002)2.46551969
100detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.46538720

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.85295501
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.14434115
3VDR_22108803_ChIP-Seq_LS180_Human3.11024164
4ZNF274_21170338_ChIP-Seq_K562_Hela2.95368524
5EWS_26573619_Chip-Seq_HEK293_Human2.84255254
6EZH2_22144423_ChIP-Seq_EOC_Human2.66810108
7ELK1_19687146_ChIP-ChIP_HELA_Human2.54738802
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.41970132
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33213630
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32341076
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28763659
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25243949
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.17001486
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13089218
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.11972145
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.02779071
17ESR1_15608294_ChIP-ChIP_MCF-7_Human1.99666429
18DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.96457392
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.95930088
20TAF15_26573619_Chip-Seq_HEK293_Human1.95166860
21FUS_26573619_Chip-Seq_HEK293_Human1.91862075
22E2F7_22180533_ChIP-Seq_HELA_Human1.91506642
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.85014226
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81756271
25MYC_18940864_ChIP-ChIP_HL60_Human1.81254680
26MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.79002907
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77690482
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73010139
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65820760
30CBP_20019798_ChIP-Seq_JUKART_Human1.65820760
31RNF2_27304074_Chip-Seq_NSC_Mouse1.63832064
32VDR_23849224_ChIP-Seq_CD4+_Human1.63024926
33P300_19829295_ChIP-Seq_ESCs_Human1.61847978
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58503640
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.52552993
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.52542946
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51805336
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.48481689
39BCAT_22108803_ChIP-Seq_LS180_Human1.47981613
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47564338
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47217254
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.45401519
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.44895961
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44847525
45FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40228122
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.40228122
47ER_23166858_ChIP-Seq_MCF-7_Human1.35751525
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35506515
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34578866
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32857596
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30205970
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28854819
53SOX2_19829295_ChIP-Seq_ESCs_Human1.26311446
54NANOG_19829295_ChIP-Seq_ESCs_Human1.26311446
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25931661
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25846170
57SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.24406113
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.23338318
59GBX2_23144817_ChIP-Seq_PC3_Human1.22938256
60FLI1_21867929_ChIP-Seq_TH2_Mouse1.22768443
61RUNX2_22187159_ChIP-Seq_PCA_Human1.22445882
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22112262
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.21727041
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21573692
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.20970748
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20961706
67FOXH1_21741376_ChIP-Seq_EPCs_Human1.20213801
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.19940993
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19670486
70TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.19540915
71CDX2_22108803_ChIP-Seq_LS180_Human1.18267263
72STAT3_23295773_ChIP-Seq_U87_Human1.17961931
73SMAD4_21799915_ChIP-Seq_A2780_Human1.16981363
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16388809
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15338119
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.14985014
77TCF4_23295773_ChIP-Seq_U87_Human1.14237624
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12855029
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12574294
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12144908
81TCF4_22108803_ChIP-Seq_LS180_Human1.11951130
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11909948
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11903018
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09297597
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09280762
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09147670
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08439912
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.08264735
89FOXP3_21729870_ChIP-Seq_TREG_Human1.07522699
90IRF1_19129219_ChIP-ChIP_H3396_Human1.06836840
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06757608
92SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.06327433
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05972854
94GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.05206016
95WDR5_24793694_ChIP-Seq_LNCAP_Human1.04204057
96GATA3_26560356_Chip-Seq_TH2_Human1.03204867
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.01018816
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.00741853
99P53_22387025_ChIP-Seq_ESCs_Mouse0.99201641
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98097913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system7.15184392
2MP0004145_abnormal_muscle_electrophysio3.36827527
3MP0001968_abnormal_touch/_nociception3.31628845
4MP0005377_hearing/vestibular/ear_phenot3.03348677
5MP0003878_abnormal_ear_physiology3.03348677
6MP0003880_abnormal_central_pattern2.71786844
7MP0002653_abnormal_ependyma_morphology2.65608301
8MP0001485_abnormal_pinna_reflex2.60342328
9MP0004885_abnormal_endolymph2.57451247
10MP0006292_abnormal_olfactory_placode2.39047867
11MP0002822_catalepsy2.30041460
12MP0005503_abnormal_tendon_morphology2.18682022
13MP0000372_irregular_coat_pigmentation2.12095594
14MP0003693_abnormal_embryo_hatching2.11059481
15MP0002102_abnormal_ear_morphology1.97296126
16MP0005171_absent_coat_pigmentation1.96760984
17MP0003567_abnormal_fetal_cardiomyocyte1.93377282
18MP0006276_abnormal_autonomic_nervous1.84709654
19MP0010094_abnormal_chromosome_stability1.79236865
20MP0000427_abnormal_hair_cycle1.68561806
21MP0005410_abnormal_fertilization1.66908770
22MP0005551_abnormal_eye_electrophysiolog1.64224985
23MP0002735_abnormal_chemical_nociception1.61749058
24MP0002751_abnormal_autonomic_nervous1.59008293
25MP0005646_abnormal_pituitary_gland1.57480544
26MP0000613_abnormal_salivary_gland1.54414442
27MP0004957_abnormal_blastocyst_morpholog1.53345591
28MP0002876_abnormal_thyroid_physiology1.48577737
29MP0008875_abnormal_xenobiotic_pharmacok1.46939908
30MP0002938_white_spotting1.46531769
31MP0002734_abnormal_mechanical_nocicepti1.43807317
32MP0000490_abnormal_crypts_of1.43178544
33MP0004142_abnormal_muscle_tone1.36338197
34MP0006035_abnormal_mitochondrial_morpho1.35571350
35MP0005645_abnormal_hypothalamus_physiol1.35090286
36MP0005075_abnormal_melanosome_morpholog1.33030342
37MP0008007_abnormal_cellular_replicative1.32508806
38MP0005084_abnormal_gallbladder_morpholo1.31668773
39MP0003806_abnormal_nucleotide_metabolis1.30311713
40MP0008789_abnormal_olfactory_epithelium1.28014228
41MP0004782_abnormal_surfactant_physiolog1.26523303
42MP0004147_increased_porphyrin_level1.26422624
43MP0002733_abnormal_thermal_nociception1.25833809
44MP0005367_renal/urinary_system_phenotyp1.22664643
45MP0000516_abnormal_urinary_system1.22664643
46MP0008872_abnormal_physiological_respon1.22124332
47MP0002067_abnormal_sensory_capabilities1.20776072
48MP0008877_abnormal_DNA_methylation1.19401886
49MP0001970_abnormal_pain_threshold1.14570279
50MP0000778_abnormal_nervous_system1.14054494
51MP0006072_abnormal_retinal_apoptosis1.13840766
52MP0001929_abnormal_gametogenesis1.12343296
53MP0002210_abnormal_sex_determination1.10479062
54MP0008058_abnormal_DNA_repair1.10383476
55MP0005253_abnormal_eye_physiology1.10007552
56MP0003137_abnormal_impulse_conducting1.03077473
57MP0001145_abnormal_male_reproductive1.00241123
58MP0000653_abnormal_sex_gland0.99876240
59MP0003950_abnormal_plasma_membrane0.98949803
60MP0004085_abnormal_heartbeat0.97830749
61MP0000647_abnormal_sebaceous_gland0.96904409
62MP0003646_muscle_fatigue0.96369982
63MP0001958_emphysema0.96316880
64MP0005220_abnormal_exocrine_pancreas0.95363658
65MP0009697_abnormal_copulation0.94168276
66MP0002272_abnormal_nervous_system0.93054222
67MP0005195_abnormal_posterior_eye0.92212732
68MP0000631_abnormal_neuroendocrine_gland0.91694961
69MP0005394_taste/olfaction_phenotype0.89999019
70MP0005499_abnormal_olfactory_system0.89999019
71MP0004215_abnormal_myocardial_fiber0.89952336
72MP0001986_abnormal_taste_sensitivity0.89432052
73MP0000685_abnormal_immune_system0.88323818
74MP0002557_abnormal_social/conspecific_i0.86160849
75MP0008775_abnormal_heart_ventricle0.85345969
76MP0003385_abnormal_body_wall0.84216375
77MP0002932_abnormal_joint_morphology0.83333069
78MP0006054_spinal_hemorrhage0.79847845
79MP0002752_abnormal_somatic_nervous0.79780645
80MP0003698_abnormal_male_reproductive0.78690584
81MP0000358_abnormal_cell_content/0.77717446
82MP0006036_abnormal_mitochondrial_physio0.76914396
83MP0002837_dystrophic_cardiac_calcinosis0.76555268
84MP0001963_abnormal_hearing_physiology0.75983167
85MP0001286_abnormal_eye_development0.74203171
86MP0002736_abnormal_nociception_after0.72373448
87MP0001243_abnormal_dermal_layer0.70339074
88MP0001544_abnormal_cardiovascular_syste0.69245961
89MP0005385_cardiovascular_system_phenoty0.69245961
90MP0009046_muscle_twitch0.68418199
91MP0001984_abnormal_olfaction0.67998466
92MP0002184_abnormal_innervation0.66810719
93MP0001177_atelectasis0.66255227
94MP0004084_abnormal_cardiac_muscle0.64832611
95MP0001529_abnormal_vocalization0.64236537
96MP0001486_abnormal_startle_reflex0.63841399
97MP0005332_abnormal_amino_acid0.63339573
98MP0001293_anophthalmia0.62980370
99MP0002069_abnormal_eating/drinking_beha0.62206370
100MP0001440_abnormal_grooming_behavior0.62200149

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)6.38884675
2Amelogenesis imperfecta (HP:0000705)5.63972443
3Septo-optic dysplasia (HP:0100842)4.83081238
4Tongue fasciculations (HP:0001308)4.30757504
5Abolished electroretinogram (ERG) (HP:0000550)4.20859748
6Decreased number of large peripheral myelinated nerve fibers (HP:0003387)4.12566517
7Hypothermia (HP:0002045)4.05760772
8Segmental peripheral demyelination/remyelination (HP:0003481)3.83063081
9Abnormality of midbrain morphology (HP:0002418)3.79263316
10Molar tooth sign on MRI (HP:0002419)3.79263316
11Muscle fibrillation (HP:0010546)3.66434046
12Nephronophthisis (HP:0000090)3.59280433
13Constricted visual fields (HP:0001133)3.47776402
14Spinal muscular atrophy (HP:0007269)3.27641118
15Impaired proprioception (HP:0010831)3.27563632
16Bifid tongue (HP:0010297)3.22161381
17Abnormality of the vocal cords (HP:0008777)3.21656766
18Hypoproteinemia (HP:0003075)3.19510498
19Tubular atrophy (HP:0000092)3.10776582
20Retinal dysplasia (HP:0007973)2.92263278
21Abnormality of macular pigmentation (HP:0008002)2.90885110
22Congenital stationary night blindness (HP:0007642)2.84784778
23Degeneration of anterior horn cells (HP:0002398)2.76141378
24Abnormality of the anterior horn cell (HP:0006802)2.76141378
25Medial flaring of the eyebrow (HP:0010747)2.75627457
26Poikiloderma (HP:0001029)2.75061250
27Abnormality of the renal medulla (HP:0100957)2.71555441
28Absent septum pellucidum (HP:0001331)2.68943394
29Adactyly (HP:0009776)2.67130965
30Dyschromatopsia (HP:0007641)2.63108740
31Optic nerve hypoplasia (HP:0000609)2.62843208
32Keratoconus (HP:0000563)2.55824894
33Increased corneal curvature (HP:0100692)2.55824894
34Decreased circulating renin level (HP:0003351)2.54248458
35Pancreatic fibrosis (HP:0100732)2.52687138
36Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.46942374
37Progressive inability to walk (HP:0002505)2.44710229
38Pancreatic cysts (HP:0001737)2.41853949
39Maternal diabetes (HP:0009800)2.40508548
40Abnormality of dental color (HP:0011073)2.37379168
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.37091547
42Abnormality of the 4th metacarpal (HP:0010012)2.30430221
43Facial diplegia (HP:0001349)2.29167958
44Prostate neoplasm (HP:0100787)2.27877669
45Short tibia (HP:0005736)2.27085397
46Abnormal drinking behavior (HP:0030082)2.24485450
47Polydipsia (HP:0001959)2.24485450
48Sclerocornea (HP:0000647)2.17138045
49Concave nail (HP:0001598)2.16347347
50Abnormality of the septum pellucidum (HP:0007375)2.16297864
51Increased CSF protein (HP:0002922)2.14149822
52Growth hormone deficiency (HP:0000824)2.05225644
53Abnormality of B cell number (HP:0010975)2.05131984
54B lymphocytopenia (HP:0010976)2.04987871
55Hypoplasia of the thymus (HP:0000778)2.01491477
56Focal seizures (HP:0007359)1.99985845
57Congenital hepatic fibrosis (HP:0002612)1.99745941
58Stomach cancer (HP:0012126)1.94740154
59Polyuria (HP:0000103)1.90432612
60Hyperglycinemia (HP:0002154)1.90156385
61Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88432145
62Aplasia/Hypoplasia involving the musculature (HP:0001460)1.86861828
63Abnormality of the 2nd finger (HP:0004100)1.85035143
64Pancreatic islet-cell hyperplasia (HP:0004510)1.84514796
65Blepharitis (HP:0000498)1.83408432
66Abnormality of incisor morphology (HP:0011063)1.82433270
67Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80998917
68Steppage gait (HP:0003376)1.79922943
69Late onset (HP:0003584)1.79857253
70Postaxial hand polydactyly (HP:0001162)1.79665268
71Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79262046
72Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79262046
73Genital tract atresia (HP:0001827)1.78417082
74Median cleft lip (HP:0000161)1.77299289
75Multiple enchondromatosis (HP:0005701)1.76655986
76Abnormality of the ileum (HP:0001549)1.76285107
77True hermaphroditism (HP:0010459)1.76204756
78Meckel diverticulum (HP:0002245)1.75624047
79Aplasia/Hypoplasia of the spleen (HP:0010451)1.75242410
80Cone-rod dystrophy (HP:0000548)1.75031639
81Abnormality of cochlea (HP:0000375)1.74785138
82Abnormality of the renal cortex (HP:0011035)1.73825994
83Cerebellar dysplasia (HP:0007033)1.73194473
84Inability to walk (HP:0002540)1.72265874
85Patellar aplasia (HP:0006443)1.71801613
86Status epilepticus (HP:0002133)1.71370515
87Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.70007306
88Abnormality of the parathyroid morphology (HP:0011766)1.69783852
89Tracheoesophageal fistula (HP:0002575)1.69621613
90Congenital primary aphakia (HP:0007707)1.69094287
91Sloping forehead (HP:0000340)1.68677985
92Panhypogammaglobulinemia (HP:0003139)1.67906170
93Aplasia/Hypoplasia of the uvula (HP:0010293)1.67386655
94Gaze-evoked nystagmus (HP:0000640)1.66263264
95Abnormality of the prostate (HP:0008775)1.66030237
96Nephrogenic diabetes insipidus (HP:0009806)1.65275261
97Dialeptic seizures (HP:0011146)1.64574342
98Abnormal rod and cone electroretinograms (HP:0008323)1.64496356
99Stridor (HP:0010307)1.63508839
100Aplasia/Hypoplasia of the patella (HP:0006498)1.62942367

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B8.90028273
2CDK86.93646383
3TGFBR15.41372572
4CDK92.81462616
5CDC72.53032781
6BLK2.29412877
7MKNK22.17448740
8VRK12.13380024
9PLK31.88000567
10FRK1.79886073
11VRK21.78983088
12TAF11.56070408
13NUAK11.52651888
14STK161.40422553
15RPS6KA41.37286499
16NEK11.28542061
17CASK1.24672567
18TLK11.23443175
19TEC1.23031827
20MKNK11.22649766
21ERBB31.11686843
22WNK31.08672090
23PKN11.08033942
24PIK3CA1.05320087
25FGFR21.00990275
26EPHA40.98542490
27ILK0.97275118
28CDK70.96487246
29ZAK0.94649603
30ADRBK20.94397407
31PLK20.93372822
32GRK10.93215366
33CCNB10.92951487
34MAPK130.92509573
35STK380.88509948
36IRAK10.83002124
37BUB10.81775075
38STK240.77447997
39CDK190.75791855
40STK38L0.74764440
41CDK30.73389996
42PRKCE0.71739514
43MUSK0.67920532
44TAOK30.67628496
45PINK10.66242014
46BMPR20.64169279
47CHEK20.62276149
48TYRO30.62276070
49ZAP700.59478559
50TRIM280.58986858
51OXSR10.57120783
52KIT0.55523152
53PRKCG0.50880888
54NTRK20.49195105
55DAPK30.45072170
56CAMK2D0.43928758
57ATR0.43656023
58DAPK10.42397758
59MAP3K120.40802951
60ACVR1B0.40358997
61CSNK1A10.38420159
62DYRK20.38245274
63ADRBK10.37311966
64MAP3K40.37169741
65ATM0.31217277
66PLK40.31175900
67ERBB40.30548592
68PLK10.29823842
69PRKACB0.28273462
70INSRR0.28181372
71CHUK0.28172580
72MAP3K20.27666884
73SYK0.27625781
74PAK30.27580651
75ROCK20.26503671
76MAP4K20.26375561
77MAP3K90.26271566
78KSR10.26136438
79CSNK1G10.23655524
80PIK3CG0.23026320
81PIM10.22700028
82RIPK40.21941772
83CSNK1G30.21518630
84MELK0.20855497
85PTK2B0.19554092
86MAPKAPK20.19311120
87MAPKAPK50.19264624
88ITK0.18152150
89RPS6KA50.17847688
90CAMK10.17772941
91CAMK2G0.16518063
92NTRK30.16409224
93PRKCD0.16297342
94CSNK1A1L0.16241149
95MINK10.15988453
96CAMK2A0.15271285
97RAF10.15037766
98EIF2AK30.14752263
99PRKG10.13925392
100TIE10.13215298

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043203.95754726
2Asthma_Homo sapiens_hsa053103.67293506
3Nitrogen metabolism_Homo sapiens_hsa009102.90319311
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.87944731
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.68865266
6Graft-versus-host disease_Homo sapiens_hsa053322.47928832
7Allograft rejection_Homo sapiens_hsa053302.39580683
8Autoimmune thyroid disease_Homo sapiens_hsa053202.35250135
9Non-homologous end-joining_Homo sapiens_hsa034502.26720008
10Homologous recombination_Homo sapiens_hsa034402.18036327
11RNA polymerase_Homo sapiens_hsa030202.11951091
12RNA degradation_Homo sapiens_hsa030182.10769054
13Phototransduction_Homo sapiens_hsa047442.08232497
14Fanconi anemia pathway_Homo sapiens_hsa034602.05457239
15Caffeine metabolism_Homo sapiens_hsa002321.95496818
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91824287
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.89111099
18Pentose phosphate pathway_Homo sapiens_hsa000301.72768839
19Type I diabetes mellitus_Homo sapiens_hsa049401.71828427
20Protein export_Homo sapiens_hsa030601.68677191
21Linoleic acid metabolism_Homo sapiens_hsa005911.63929426
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55064341
23One carbon pool by folate_Homo sapiens_hsa006701.52790218
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.48843664
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46737270
26Base excision repair_Homo sapiens_hsa034101.44271538
27RNA transport_Homo sapiens_hsa030131.41809899
28Basal transcription factors_Homo sapiens_hsa030221.40163570
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38709109
30Propanoate metabolism_Homo sapiens_hsa006401.38512243
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.27022492
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24949929
33Sulfur metabolism_Homo sapiens_hsa009201.21990001
34Mismatch repair_Homo sapiens_hsa034301.20580587
35Staphylococcus aureus infection_Homo sapiens_hsa051501.20017170
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.17065799
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15764001
38Selenocompound metabolism_Homo sapiens_hsa004501.10654800
39Steroid biosynthesis_Homo sapiens_hsa001001.08517133
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08430060
41Hematopoietic cell lineage_Homo sapiens_hsa046401.04879733
42DNA replication_Homo sapiens_hsa030301.04395932
43Viral myocarditis_Homo sapiens_hsa054161.02397554
44Ether lipid metabolism_Homo sapiens_hsa005651.02172759
45Olfactory transduction_Homo sapiens_hsa047401.00584013
46Arachidonic acid metabolism_Homo sapiens_hsa005901.00021643
47Rheumatoid arthritis_Homo sapiens_hsa053230.99511685
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.99215617
49Antigen processing and presentation_Homo sapiens_hsa046120.93550276
50Parkinsons disease_Homo sapiens_hsa050120.91558933
51Pyrimidine metabolism_Homo sapiens_hsa002400.90226604
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88719213
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.87357778
54Peroxisome_Homo sapiens_hsa041460.84035767
55Huntingtons disease_Homo sapiens_hsa050160.83560240
56Proteasome_Homo sapiens_hsa030500.81460125
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78576409
58Vitamin digestion and absorption_Homo sapiens_hsa049770.78073541
59Butanoate metabolism_Homo sapiens_hsa006500.76776340
60Oxidative phosphorylation_Homo sapiens_hsa001900.76387374
61Fat digestion and absorption_Homo sapiens_hsa049750.74297782
62Purine metabolism_Homo sapiens_hsa002300.72932389
63Leishmaniasis_Homo sapiens_hsa051400.71557111
64Regulation of autophagy_Homo sapiens_hsa041400.69651368
65Calcium signaling pathway_Homo sapiens_hsa040200.66524418
66TGF-beta signaling pathway_Homo sapiens_hsa043500.66279158
67Nucleotide excision repair_Homo sapiens_hsa034200.63402630
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62744797
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61067088
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59477829
71Dopaminergic synapse_Homo sapiens_hsa047280.56632816
72Taste transduction_Homo sapiens_hsa047420.54548928
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48450567
74Vitamin B6 metabolism_Homo sapiens_hsa007500.47671770
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45164663
76mRNA surveillance pathway_Homo sapiens_hsa030150.45132439
77Glucagon signaling pathway_Homo sapiens_hsa049220.42836170
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42789239
79Systemic lupus erythematosus_Homo sapiens_hsa053220.42585046
80Glycerolipid metabolism_Homo sapiens_hsa005610.37922363
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36278159
82Insulin secretion_Homo sapiens_hsa049110.36076494
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36014865
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35731540
85Metabolic pathways_Homo sapiens_hsa011000.35135708
86Cell cycle_Homo sapiens_hsa041100.34849984
87Pyruvate metabolism_Homo sapiens_hsa006200.34844464
88Type II diabetes mellitus_Homo sapiens_hsa049300.34756024
89Morphine addiction_Homo sapiens_hsa050320.34715393
90Tryptophan metabolism_Homo sapiens_hsa003800.33904020
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33771606
92Toxoplasmosis_Homo sapiens_hsa051450.33012208
93Fatty acid biosynthesis_Homo sapiens_hsa000610.29623586
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28005502
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26473704
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26198660
97Collecting duct acid secretion_Homo sapiens_hsa049660.25222020
98Oocyte meiosis_Homo sapiens_hsa041140.23672939
99Hippo signaling pathway_Homo sapiens_hsa043900.23232706
100Serotonergic synapse_Homo sapiens_hsa047260.22029091

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