ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	8.80995271
2	viral transcription (GO:0019083)	8.73888752
3	ribosomal small subunit biogenesis (GO:0042274)	8.71654812
4	translational termination (GO:0006415)	8.35192993
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.99649558
6	protein targeting to ER (GO:0045047)	6.93489929
7	cotranslational protein targeting to membrane (GO:0006613)	6.87194177
8	translational elongation (GO:0006414)	6.78032906
9	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.65218436
10	protein localization to endoplasmic reticulum (GO:0070972)	6.49125371
11	cellular protein complex disassembly (GO:0043624)	6.33992465
12	viral life cycle (GO:0019058)	6.27891575
13	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.27881192
14	maturation of SSU-rRNA (GO:0030490)	5.70295541
15	protein complex disassembly (GO:0043241)	5.45579098
16	translational initiation (GO:0006413)	5.35262542
17	ATP synthesis coupled proton transport (GO:0015986)	5.20730259
18	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.20730259
19	labyrinthine layer development (GO:0060711)	5.13501435
20	macromolecular complex disassembly (GO:0032984)	5.09701227
21	protein targeting to membrane (GO:0006612)	4.74540589
22	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.66037078
23	chaperone-mediated protein transport (GO:0072321)	4.42545487
24	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.35576443
25	ncRNA 3-end processing (GO:0043628)	4.26246558
26	protein neddylation (GO:0045116)	4.18036211
27	mRNA catabolic process (GO:0006402)	4.13818965
28	translation (GO:0006412)	4.07939942
29	behavioral response to nicotine (GO:0035095)	4.07819700
30	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.95919899
31	ribosomal large subunit biogenesis (GO:0042273)	3.93468269
32	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.87972009
33	response to misfolded protein (GO:0051788)	3.84405956
34	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.75112627
35	response to nitric oxide (GO:0071731)	3.74303861
36	GTP biosynthetic process (GO:0006183)	3.70113844
37	RNA catabolic process (GO:0006401)	3.66268111
38	pyrimidine nucleobase catabolic process (GO:0006208)	3.54888614
39	ribonucleoprotein complex biogenesis (GO:0022613)	3.49306044
40	cell proliferation in forebrain (GO:0021846)	3.44789601
41	protein complex biogenesis (GO:0070271)	3.42410877
42	UTP biosynthetic process (GO:0006228)	3.37542674
43	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.37537676
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.37537676
45	NADH dehydrogenase complex assembly (GO:0010257)	3.37537676
46	respiratory electron transport chain (GO:0022904)	3.37159091
47	positive regulation of digestive system process (GO:0060456)	3.37092750
48	cellular component biogenesis (GO:0044085)	3.37018781
49	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.36744352
50	substrate-independent telencephalic tangential migration (GO:0021826)	3.36744352
51	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.33884292
52	electron transport chain (GO:0022900)	3.33854138
53	somite development (GO:0061053)	3.30455606
54	heart trabecula formation (GO:0060347)	3.28002232
55	establishment of protein localization to membrane (GO:0090150)	3.21039710
56	regulation of G0 to G1 transition (GO:0070316)	3.12547505
57	UTP metabolic process (GO:0046051)	3.12418695
58	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.09730928
59	superoxide anion generation (GO:0042554)	3.07129039
60	mitochondrial respiratory chain complex assembly (GO:0033108)	3.06574875
61	pattern specification involved in kidney development (GO:0061004)	3.06159429
62	nucleobase catabolic process (GO:0046113)	3.06140214
63	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.04854715
64	positive regulation of respiratory burst (GO:0060267)	3.04385615
65	tongue development (GO:0043586)	3.01869189
66	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.99304925
67	protein targeting (GO:0006605)	2.99294183
68	ovulation cycle (GO:0042698)	2.98647481
69	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.97893908
70	establishment of planar polarity (GO:0001736)	2.91017654
71	establishment of tissue polarity (GO:0007164)	2.91017654
72	CTP metabolic process (GO:0046036)	2.87466285
73	CTP biosynthetic process (GO:0006241)	2.87466285
74	protein hydroxylation (GO:0018126)	2.86411085
75	parturition (GO:0007567)	2.82374423
76	icosanoid secretion (GO:0032309)	2.81926652
77	arachidonic acid secretion (GO:0050482)	2.81926652
78	4-hydroxyproline metabolic process (GO:0019471)	2.81770053
79	dendritic spine morphogenesis (GO:0060997)	2.80565880
80	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.78417137
81	ATP biosynthetic process (GO:0006754)	2.76944213
82	neurofilament cytoskeleton organization (GO:0060052)	2.76757881
83	negative regulation of organelle assembly (GO:1902116)	2.76552190
84	hydrogen ion transmembrane transport (GO:1902600)	2.74515971
85	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.74240993
86	establishment of protein localization to organelle (GO:0072594)	2.69591027
87	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.68534193
88	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.67632396
89	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.67268913
90	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.65633972
91	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.65118558
92	cornea development in camera-type eye (GO:0061303)	2.65005193
93	peptidyl-proline hydroxylation (GO:0019511)	2.63285439
94	positive regulation of fatty acid oxidation (GO:0046321)	2.63048947
95	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.62046803
96	establishment of mitochondrion localization (GO:0051654)	2.61822064
97	heparan sulfate proteoglycan biosynthetic process (GO:0015012)	2.59485763
98	glycerophospholipid catabolic process (GO:0046475)	2.58696390
99	cytochrome complex assembly (GO:0017004)	2.55969903
100	segment specification (GO:0007379)	2.55007093

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.60232537
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.82962068
3	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	3.17813385
4	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.76078844
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.39514622
6	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.39257357
7	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.22512449
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.21938855
9	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.05066109
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.02940490
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.91944404
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.91227476
13	REST_21632747_ChIP-Seq_MESCs_Mouse	1.87465763
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.87445568
15	IRF1_19129219_ChIP-ChIP_H3396_Human	1.86831845
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.83491404
17	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.83487078
18	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.79868378
19	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.79868378
20	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.79819017
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79150360
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.76522211
23	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.75446745
24	TTF2_22483619_ChIP-Seq_HELA_Human	1.74233592
25	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.71511940
26	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.71442320
27	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.71328322
28	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.70883875
29	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.70556603
30	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.67891790
31	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.65998991
32	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.64952147
33	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.64902557
34	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.60866296
35	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.60290782
36	CTCF_27219007_Chip-Seq_Bcells_Human	1.58740646
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.58414603
38	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.57970136
39	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.55108368
40	XRN2_22483619_ChIP-Seq_HELA_Human	1.52568289
41	ZNF274_21170338_ChIP-Seq_K562_Hela	1.49372246
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.48758283
43	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.43249089
44	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.41240607
45	IGF1R_20145208_ChIP-Seq_DFB_Human	1.40877128
46	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.39752495
47	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.38725597
48	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.38575138
49	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.35600594
50	VDR_22108803_ChIP-Seq_LS180_Human	1.35576867
51	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.35020312
52	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.33692247
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32269499
54	NCOR_22424771_ChIP-Seq_293T_Human	1.32093595
55	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.30866895
56	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.30499766
57	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.28950365
58	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.28945733
59	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.28177252
60	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.27727991
61	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.26541273
62	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.25974694
63	TP53_22573176_ChIP-Seq_HFKS_Human	1.23412739
64	TAF2_19829295_ChIP-Seq_ESCs_Human	1.21324553
65	GABP_19822575_ChIP-Seq_HepG2_Human	1.19738781
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18842689
67	RNF2_27304074_Chip-Seq_NSC_Mouse	1.17875115
68	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.17503275
69	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.13719016
70	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.13635802
71	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.12060657
72	TP53_22127205_ChIP-Seq_IMR90_Human	1.09333630
73	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.09101810
74	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.07473405
75	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.07374881
76	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.06175099
77	HTT_18923047_ChIP-ChIP_STHdh_Human	1.05406804
78	MYC_19829295_ChIP-Seq_ESCs_Human	1.05214752
79	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.05062419
80	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.04243770
81	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.04097276
82	ERA_21632823_ChIP-Seq_H3396_Human	1.03805536
83	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.02945734
84	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02468357
85	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.01708264
86	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01413738
87	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.00562920
88	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.99512854
89	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.98183869
90	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.97423835
91	SA1_27219007_Chip-Seq_Bcells_Human	0.96705701
92	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.94854224
93	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.94545359
94	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.94341243
95	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.93822955
96	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.93565551
97	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.93103623
98	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.93103623
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92294665
100	BCL6_27268052_Chip-Seq_Bcells_Human	0.91669585

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.64605845
2	MP0001348_abnormal_lacrimal_gland	4.43685815
3	MP0006292_abnormal_olfactory_placode	3.58558283
4	MP0005083_abnormal_biliary_tract	3.47369825
5	MP0003646_muscle_fatigue	3.27480680
6	MP0003787_abnormal_imprinting	3.26205678
7	MP0003123_paternal_imprinting	3.21642677
8	MP0003315_abnormal_perineum_morphology	2.86416635
9	MP0000566_synostosis	2.67685533
10	MP0002638_abnormal_pupillary_reflex	2.35780001
11	MP0005646_abnormal_pituitary_gland	2.26157049
12	MP0003121_genomic_imprinting	2.22114474
13	MP0008877_abnormal_DNA_methylation	2.19135245
14	MP0003122_maternal_imprinting	2.12219358
15	MP0006276_abnormal_autonomic_nervous	1.98753430
16	MP0005377_hearing/vestibular/ear_phenot	1.98648267
17	MP0003878_abnormal_ear_physiology	1.98648267
18	MP0003880_abnormal_central_pattern	1.98176164
19	MP0008789_abnormal_olfactory_epithelium	1.95073299
20	MP0005084_abnormal_gallbladder_morpholo	1.86508373
21	MP0002653_abnormal_ependyma_morphology	1.79655757
22	MP0001293_anophthalmia	1.76865806
23	MP0004142_abnormal_muscle_tone	1.76844527
24	MP0005499_abnormal_olfactory_system	1.73105191
25	MP0005394_taste/olfaction_phenotype	1.73105191
26	MP0004145_abnormal_muscle_electrophysio	1.71567641
27	MP0003136_yellow_coat_color	1.66105894
28	MP0001919_abnormal_reproductive_system	1.58711145
29	MP0003879_abnormal_hair_cell	1.57785945
30	MP0004858_abnormal_nervous_system	1.56298796
31	MP0003567_abnormal_fetal_cardiomyocyte	1.52037238
32	MP0000049_abnormal_middle_ear	1.47527072
33	MP0001984_abnormal_olfaction	1.44872714
34	MP0005187_abnormal_penis_morphology	1.44778874
35	MP0002160_abnormal_reproductive_system	1.44044784
36	MP0002272_abnormal_nervous_system	1.40727144
37	MP0000613_abnormal_salivary_gland	1.37985211
38	MP0003942_abnormal_urinary_system	1.27907065
39	MP0005389_reproductive_system_phenotype	1.25883042
40	MP0004885_abnormal_endolymph	1.20974846
41	MP0004043_abnormal_pH_regulation	1.19446834
42	MP0002132_abnormal_respiratory_system	1.18581772
43	MP0009384_cardiac_valve_regurgitation	1.17599348
44	MP0005423_abnormal_somatic_nervous	1.16369890
45	MP0009745_abnormal_behavioral_response	1.12462071
46	MP0004742_abnormal_vestibular_system	1.10745279
47	MP0001970_abnormal_pain_threshold	1.09627148
48	MP0001440_abnormal_grooming_behavior	1.09449661
49	MP0002557_abnormal_social/conspecific_i	1.08596785
50	MP0001299_abnormal_eye_distance/	1.08002373
51	MP0002063_abnormal_learning/memory/cond	1.07789505
52	MP0001485_abnormal_pinna_reflex	1.02844259
53	MP0000778_abnormal_nervous_system	1.02128193
54	MP0001968_abnormal_touch/_nociception	0.99354427
55	MP0000955_abnormal_spinal_cord	0.99297308
56	MP0002837_dystrophic_cardiac_calcinosis	0.98349989
57	MP0002184_abnormal_innervation	0.97395113
58	MP0005195_abnormal_posterior_eye	0.96151477
59	MP0003635_abnormal_synaptic_transmissio	0.95659270
60	MP0004147_increased_porphyrin_level	0.94490768
61	MP0003938_abnormal_ear_development	0.94195373
62	MP0000383_abnormal_hair_follicle	0.94019515
63	MP0002138_abnormal_hepatobiliary_system	0.93265841
64	MP0000026_abnormal_inner_ear	0.91855098
65	MP0002752_abnormal_somatic_nervous	0.91419545
66	MP0009046_muscle_twitch	0.91045047
67	MP0005645_abnormal_hypothalamus_physiol	0.90756972
68	MP0002234_abnormal_pharynx_morphology	0.90007706
69	MP0000631_abnormal_neuroendocrine_gland	0.88085288
70	MP0004484_altered_response_of	0.87174306
71	MP0001905_abnormal_dopamine_level	0.86745838
72	MP0004859_abnormal_synaptic_plasticity	0.86702558
73	MP0002733_abnormal_thermal_nociception	0.85732883
74	MP0002064_seizures	0.85039148
75	MP0006072_abnormal_retinal_apoptosis	0.83398683
76	MP0002067_abnormal_sensory_capabilities	0.81643858
77	MP0008995_early_reproductive_senescence	0.81191260
78	MP0002572_abnormal_emotion/affect_behav	0.79866953
79	MP0002102_abnormal_ear_morphology	0.79561752
80	MP0002882_abnormal_neuron_morphology	0.79051427
81	MP0002163_abnormal_gland_morphology	0.74910172
82	MP0002736_abnormal_nociception_after	0.71931278
83	MP0002735_abnormal_chemical_nociception	0.70502302
84	MP0003186_abnormal_redox_activity	0.70401889
85	MP0001664_abnormal_digestion	0.70172207
86	MP0002210_abnormal_sex_determination	0.70008677
87	MP0003890_abnormal_embryonic-extraembry	0.69307633
88	MP0001963_abnormal_hearing_physiology	0.69272860
89	MP0003936_abnormal_reproductive_system	0.68900630
90	MP0003786_premature_aging	0.68878036
91	MP0002092_abnormal_eye_morphology	0.68405733
92	MP0003755_abnormal_palate_morphology	0.68180842
93	MP0004133_heterotaxia	0.67927420
94	MP0010386_abnormal_urinary_bladder	0.67527291
95	MP0002233_abnormal_nose_morphology	0.66133569
96	MP0009053_abnormal_anal_canal	0.65922620
97	MP0002822_catalepsy	0.64575507
98	MP0003806_abnormal_nucleotide_metabolis	0.62793864
99	MP0005551_abnormal_eye_electrophysiolog	0.62045546
100	MP0001145_abnormal_male_reproductive	0.61788648

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.51467150
2	Macrocytic anemia (HP:0001972)	4.27245543
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.18251849
4	Increased intramyocellular lipid droplets (HP:0012240)	3.91975499
5	Hyperglycinemia (HP:0002154)	3.81740559
6	Acute necrotizing encephalopathy (HP:0006965)	3.74670832
7	Increased hepatocellular lipid droplets (HP:0006565)	3.67095105
8	Lipid accumulation in hepatocytes (HP:0006561)	3.64973370
9	Increased muscle lipid content (HP:0009058)	3.49457314
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.47910757
11	Acute encephalopathy (HP:0006846)	3.37091900
12	Pallor (HP:0000980)	3.32418694
13	Aplasia/Hypoplasia of the spleen (HP:0010451)	3.25657056
14	Pancreatic fibrosis (HP:0100732)	3.22049723
15	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.20217198
16	Mitochondrial inheritance (HP:0001427)	3.14704952
17	Congenital malformation of the right heart (HP:0011723)	3.14585328
18	Double outlet right ventricle (HP:0001719)	3.14585328
19	Asplenia (HP:0001746)	3.13984881
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.11452184
21	Renal Fanconi syndrome (HP:0001994)	3.08053518
22	Progressive macrocephaly (HP:0004481)	2.97558286
23	Stenosis of the external auditory canal (HP:0000402)	2.96859272
24	Anomalous pulmonary venous return (HP:0010772)	2.93994479
25	Abnormal number of erythroid precursors (HP:0012131)	2.93754043
26	Severe visual impairment (HP:0001141)	2.86333391
27	Abnormality of urine glucose concentration (HP:0011016)	2.85126271
28	Glycosuria (HP:0003076)	2.85126271
29	3-Methylglutaconic aciduria (HP:0003535)	2.84170266
30	Increased CSF lactate (HP:0002490)	2.80980713
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.80848961
32	Rectal prolapse (HP:0002035)	2.80225456
33	Congenital stationary night blindness (HP:0007642)	2.78600088
34	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.70986151
35	Anosmia (HP:0000458)	2.69525225
36	Myokymia (HP:0002411)	2.66313249
37	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.66198883
38	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.66198883
39	Nephronophthisis (HP:0000090)	2.65113966
40	Absent thumb (HP:0009777)	2.65084209
41	Colon cancer (HP:0003003)	2.58554308
42	Abnormality of the pulmonary veins (HP:0011718)	2.53831306
43	Exertional dyspnea (HP:0002875)	2.51647816
44	Rib fusion (HP:0000902)	2.45957835
45	Confusion (HP:0001289)	2.45708183
46	Agitation (HP:0000713)	2.36137547
47	True hermaphroditism (HP:0010459)	2.34664372
48	Respiratory difficulties (HP:0002880)	2.33056151
49	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.32663497
50	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.31060565
51	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.31060565
52	Hyperphosphaturia (HP:0003109)	2.27031070
53	Cerebral edema (HP:0002181)	2.24978790
54	Depressed nasal ridge (HP:0000457)	2.24625840
55	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.23279096
56	Pachygyria (HP:0001302)	2.20015336
57	Septo-optic dysplasia (HP:0100842)	2.19374180
58	Lethargy (HP:0001254)	2.18519075
59	Broad distal phalanx of finger (HP:0009836)	2.14644286
60	Elevated erythrocyte sedimentation rate (HP:0003565)	2.14452206
61	Hypogonadotrophic hypogonadism (HP:0000044)	2.13187030
62	Small hand (HP:0200055)	2.10559406
63	Ectopic kidney (HP:0000086)	2.09871685
64	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.06380788
65	Abnormality of the corticospinal tract (HP:0002492)	2.06070743
66	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.04236382
67	Hepatocellular necrosis (HP:0001404)	2.01323280
68	Methylmalonic aciduria (HP:0012120)	2.01261839
69	Optic disc pallor (HP:0000543)	2.00867411
70	Lactic acidosis (HP:0003128)	1.99453622
71	Deep palmar crease (HP:0006191)	1.99126702
72	Onycholysis (HP:0001806)	1.98875100
73	Supernumerary spleens (HP:0009799)	1.95988291
74	Horseshoe kidney (HP:0000085)	1.95304170
75	Triphalangeal thumb (HP:0001199)	1.94591256
76	11 pairs of ribs (HP:0000878)	1.94452915
77	Abnormality of the renal medulla (HP:0100957)	1.92569616
78	Esophageal atresia (HP:0002032)	1.91720999
79	Sclerocornea (HP:0000647)	1.90706289
80	Hepatic necrosis (HP:0002605)	1.90002638
81	Abnormality of alanine metabolism (HP:0010916)	1.89036711
82	Hyperalaninemia (HP:0003348)	1.89036711
83	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.89036711
84	Abnormal urine phosphate concentration (HP:0012599)	1.88000578
85	Abdominal situs inversus (HP:0003363)	1.87587240
86	Abnormality of abdominal situs (HP:0011620)	1.87587240
87	Partial agenesis of the corpus callosum (HP:0001338)	1.85367829
88	Pseudobulbar signs (HP:0002200)	1.85152898
89	Hypoplasia of the radius (HP:0002984)	1.84103710
90	Methylmalonic acidemia (HP:0002912)	1.80319677
91	Abnormality of renal resorption (HP:0011038)	1.79431252
92	Adducted thumb (HP:0001181)	1.77379826
93	Anencephaly (HP:0002323)	1.76969547
94	Exercise intolerance (HP:0003546)	1.75105837
95	Cerebellar dysplasia (HP:0007033)	1.74480895
96	Medial flaring of the eyebrow (HP:0010747)	1.74452456
97	Hyperthyroidism (HP:0000836)	1.74296633
98	Short femoral neck (HP:0100864)	1.73655796
99	Pendular nystagmus (HP:0012043)	1.72859961
100	Prolonged partial thromboplastin time (HP:0003645)	1.71321460

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.58906278
2	PBK	3.39955707
3	PIK3CA	3.22354400
4	BCKDK	3.18665307
5	TAOK3	2.97551262
6	PINK1	2.55813008
7	MAP3K11	2.44333661
8	ZAK	2.40895044
9	GRK1	2.40629856
10	CDC7	2.35678402
11	PDK2	2.24293212
12	WNK4	2.17406110
13	ADRBK2	2.14999395
14	MAP3K10	2.05991127
15	CASK	2.01942239
16	PLK4	1.96904172
17	EPHB2	1.86838841
18	LRRK2	1.84035341
19	TXK	1.83727354
20	CDK19	1.80995294
21	DYRK2	1.79069550
22	NEK1	1.77079096
23	NME2	1.72775438
24	DMPK	1.70206563
25	NTRK2	1.69692402
26	MINK1	1.41900930
27	MAP3K6	1.35368156
28	NUAK1	1.32249297
29	CAMK1D	1.28527840
30	KDR	1.28138203
31	PRKCG	1.22796578
32	PLK1	1.20296544
33	AURKA	1.19473919
34	MAPK7	1.12936692
35	ADRBK1	1.06745740
36	EPHA4	1.02932032
37	WNK3	0.99427626
38	CAMK1G	0.97523962
39	PTK6	0.97233796
40	TIE1	0.94064827
41	ABL2	0.92058724
42	DAPK3	0.91831027
43	VRK2	0.91503138
44	CAMK1	0.90395531
45	PRKD3	0.83460857
46	ILK	0.83267380
47	FRK	0.77605791
48	PAK3	0.76402765
49	MAP2K4	0.75801196
50	NEK2	0.75526557
51	CSNK1E	0.73980786
52	MAP2K2	0.72513877
53	LIMK1	0.70326514
54	MAP2K6	0.66678290
55	INSRR	0.63879606
56	CSNK2A2	0.62313142
57	MAP2K7	0.59931758
58	PRKCQ	0.57708447
59	BRSK1	0.57420501
60	WEE1	0.54903610
61	CAMKK2	0.54670482
62	PIM2	0.54262785
63	TYRO3	0.54108949
64	PRKACA	0.53985671
65	BRSK2	0.53916237
66	RPS6KA6	0.53882777
67	PRKCH	0.53248052
68	TESK2	0.53205285
69	PRKCZ	0.52423569
70	AURKB	0.51495324
71	MAPK13	0.51187249
72	MARK1	0.44629359
73	OBSCN	0.44602913
74	PTK2	0.44452725
75	NTRK3	0.44418651
76	NEK9	0.43808285
77	DYRK1B	0.43724841
78	PASK	0.43709994
79	TGFBR1	0.43015899
80	CSNK1G2	0.43006459
81	STK11	0.42411972
82	TNIK	0.42406904
83	STK39	0.42375498
84	PLK2	0.41975670
85	AKT1	0.40541469
86	RPS6KB2	0.40065605
87	ERBB2	0.39335401
88	PRKCA	0.38760038
89	PRKACG	0.38678819
90	CHEK2	0.38284751
91	BCR	0.36671868
92	MYLK	0.36137013
93	MAP3K9	0.36097836
94	CSNK2A1	0.35656111
95	CAMKK1	0.35624306
96	MAPK12	0.35281628
97	SGK1	0.35065192
98	RPS6KL1	0.33605048
99	RPS6KC1	0.33605048
100	VRK1	0.33589391

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.77648550
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.41055357
3	Parkinsons disease_Homo sapiens_hsa05012	3.92096056
4	Cardiac muscle contraction_Homo sapiens_hsa04260	3.20444140
5	Homologous recombination_Homo sapiens_hsa03440	2.53024435
6	Alzheimers disease_Homo sapiens_hsa05010	2.49367728
7	Huntingtons disease_Homo sapiens_hsa05016	2.44451279
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.35008741
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.30627250
10	Peroxisome_Homo sapiens_hsa04146	2.10849404
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.08935496
12	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.98293539
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.87905015
14	DNA replication_Homo sapiens_hsa03030	1.70665710
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.70577677
16	Protein export_Homo sapiens_hsa03060	1.64581165
17	RNA degradation_Homo sapiens_hsa03018	1.64562304
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.58163985
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.56397175
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.45902605
21	Nicotine addiction_Homo sapiens_hsa05033	1.43494524
22	Basal cell carcinoma_Homo sapiens_hsa05217	1.39955393
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.37343034
24	Retinol metabolism_Homo sapiens_hsa00830	1.27043525
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13664759
26	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.11457063
27	Phototransduction_Homo sapiens_hsa04744	1.08627795
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.08573406
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.02529556
30	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.01070847
31	Mismatch repair_Homo sapiens_hsa03430	0.98557878
32	Fat digestion and absorption_Homo sapiens_hsa04975	0.97322899
33	Butanoate metabolism_Homo sapiens_hsa00650	0.96450574
34	RNA polymerase_Homo sapiens_hsa03020	0.95779637
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.92462450
36	Collecting duct acid secretion_Homo sapiens_hsa04966	0.92412636
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.91192935
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90169138
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.83031023
40	Metabolic pathways_Homo sapiens_hsa01100	0.78280051
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77577261
42	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76288554
43	Olfactory transduction_Homo sapiens_hsa04740	0.69766313
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68895766
45	Fatty acid elongation_Homo sapiens_hsa00062	0.68327467
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.68024917
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66671043
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.66294660
49	Proteasome_Homo sapiens_hsa03050	0.64860055
50	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.64201822
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64199180
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.63352004
53	Propanoate metabolism_Homo sapiens_hsa00640	0.63010486
54	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.61887737
55	ABC transporters_Homo sapiens_hsa02010	0.61013800
56	Morphine addiction_Homo sapiens_hsa05032	0.60274521
57	Caffeine metabolism_Homo sapiens_hsa00232	0.59906574
58	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53870643
59	GABAergic synapse_Homo sapiens_hsa04727	0.53769039
60	Pancreatic secretion_Homo sapiens_hsa04972	0.52560415
61	Sulfur relay system_Homo sapiens_hsa04122	0.52292845
62	Base excision repair_Homo sapiens_hsa03410	0.51693336
63	Purine metabolism_Homo sapiens_hsa00230	0.51646189
64	Arginine and proline metabolism_Homo sapiens_hsa00330	0.50789553
65	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.47208182
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46525453
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45358005
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.44321187
69	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.43579793
70	Taste transduction_Homo sapiens_hsa04742	0.39855477
71	Fatty acid degradation_Homo sapiens_hsa00071	0.35857860
72	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.35777826
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.35642137
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.34979673
75	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.34842423
76	p53 signaling pathway_Homo sapiens_hsa04115	0.34691864
77	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.33677912
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.29829545
79	Spliceosome_Homo sapiens_hsa03040	0.28410406
80	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.27906919
81	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.27620122
82	Basal transcription factors_Homo sapiens_hsa03022	0.27533941
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.27041963
84	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.26215473
85	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.26163844
86	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.26152958
87	Melanoma_Homo sapiens_hsa05218	0.25966457
88	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.24159943
89	Melanogenesis_Homo sapiens_hsa04916	0.23381746
90	Serotonergic synapse_Homo sapiens_hsa04726	0.23020823
91	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.22799127
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.22592097
93	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.21977948
94	RNA transport_Homo sapiens_hsa03013	0.20699475
95	Insulin secretion_Homo sapiens_hsa04911	0.20018538
96	Axon guidance_Homo sapiens_hsa04360	0.18510848
97	Wnt signaling pathway_Homo sapiens_hsa04310	0.17884891
98	Ras signaling pathway_Homo sapiens_hsa04014	0.14954648
99	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.14891552
100	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.14608921

RPL31P56

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »