RPL31P58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)8.57631760
2cellular response to vitamin (GO:0071295)7.10154883
3nucleobase catabolic process (GO:0046113)7.00284743
4response to UV-C (GO:0010225)6.96101863
5melanin biosynthetic process (GO:0042438)6.69724832
6negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)6.63181240
7negative regulation of cell cycle arrest (GO:0071157)6.51820684
8melanin metabolic process (GO:0006582)6.20903317
9negative regulation of norepinephrine secretion (GO:0010700)6.11305879
10secondary metabolite biosynthetic process (GO:0044550)6.09144373
11embryonic camera-type eye development (GO:0031076)5.60003916
12hair cell differentiation (GO:0035315)5.54826205
13positive regulation of protein export from nucleus (GO:0046827)5.18210339
14response to magnesium ion (GO:0032026)5.07279267
15cell migration involved in heart development (GO:0060973)5.06062249
16positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)5.01755247
17venous blood vessel morphogenesis (GO:0048845)4.95892186
18cellular response to antibiotic (GO:0071236)4.90655732
19ketone body metabolic process (GO:1902224)4.75143996
20ventricular cardiac muscle cell development (GO:0055015)4.73888542
21positive regulation of cell cycle G1/S phase transition (GO:1902808)4.69875643
22lung morphogenesis (GO:0060425)4.68464749
23regulation of nuclear cell cycle DNA replication (GO:0033262)4.65958450
24left/right axis specification (GO:0070986)4.60988224
25negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.59198711
26central nervous system projection neuron axonogenesis (GO:0021952)4.26056158
27negative regulation of catecholamine secretion (GO:0033604)4.13024369
28cellular response to toxic substance (GO:0097237)4.11967238
29protein K11-linked deubiquitination (GO:0035871)4.08383520
30positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.00783960
31female gonad development (GO:0008585)3.91937862
32melanosome organization (GO:0032438)3.84620619
33regulation of penile erection (GO:0060405)3.71110691
34pigment granule organization (GO:0048753)3.70949985
35negative regulation of signal transduction by p53 class mediator (GO:1901797)3.58936040
36detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.53708410
37central nervous system neuron axonogenesis (GO:0021955)3.48342090
38male meiosis (GO:0007140)3.45357595
39ganglion development (GO:0061548)3.41222948
40ventricular septum morphogenesis (GO:0060412)3.38903761
41nerve growth factor signaling pathway (GO:0038180)3.38075106
42sympathetic nervous system development (GO:0048485)3.37726521
43synaptonemal complex assembly (GO:0007130)3.33737021
44exocrine pancreas development (GO:0031017)3.31014800
45synaptonemal complex organization (GO:0070193)3.27431894
46melanocyte differentiation (GO:0030318)3.26388974
47regulation of norepinephrine secretion (GO:0014061)3.23936537
48response to cocaine (GO:0042220)3.23885703
49phenol-containing compound biosynthetic process (GO:0046189)3.21610053
50olfactory bulb development (GO:0021772)3.20406485
51digestive tract morphogenesis (GO:0048546)3.17106065
52postsynaptic membrane organization (GO:0001941)3.14878851
53retinal ganglion cell axon guidance (GO:0031290)3.08729230
54piRNA metabolic process (GO:0034587)3.06746296
55mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.06497572
56response to iron ion (GO:0010039)3.05603464
57short-chain fatty acid metabolic process (GO:0046459)3.05178326
58dentate gyrus development (GO:0021542)3.04914710
59cellular response to nutrient (GO:0031670)3.04632305
60neuron recognition (GO:0008038)3.01830807
61pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.99687313
62UMP metabolic process (GO:0046049)2.99687313
63pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.99687313
64UMP biosynthetic process (GO:0006222)2.99687313
65peristalsis (GO:0030432)2.97380641
66response to vitamin A (GO:0033189)2.94269258
67neuroepithelial cell differentiation (GO:0060563)2.92291958
68pigment cell differentiation (GO:0050931)2.90889225
69myoblast fusion (GO:0007520)2.90614840
70protein destabilization (GO:0031648)2.90370175
71positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.87171236
72embryonic digestive tract morphogenesis (GO:0048557)2.86930815
73regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.85753561
74regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)2.84613237
75positive regulation of developmental pigmentation (GO:0048087)2.83478406
76DNA damage response, detection of DNA damage (GO:0042769)2.81732782
77regulation of protein export from nucleus (GO:0046825)2.80668137
78regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.79817490
79epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79693951
80rRNA methylation (GO:0031167)2.78090052
81regulation of inositol phosphate biosynthetic process (GO:0010919)2.75047783
82phasic smooth muscle contraction (GO:0014821)2.73400444
83inositol phosphate catabolic process (GO:0071545)2.73273415
84ncRNA catabolic process (GO:0034661)2.70735046
85regulation of telomere maintenance via telomerase (GO:0032210)2.69616138
86regulation of hexokinase activity (GO:1903299)2.69040455
87regulation of glucokinase activity (GO:0033131)2.69040455
88opioid receptor signaling pathway (GO:0038003)2.69018686
89cellular response to estrogen stimulus (GO:0071391)2.68322874
90neural crest cell migration (GO:0001755)2.66610037
91brain morphogenesis (GO:0048854)2.66575366
92replication fork processing (GO:0031297)2.65859017
93rRNA catabolic process (GO:0016075)2.64093677
94membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.63800285
95rRNA modification (GO:0000154)2.62993480
96RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.61451424
97neuron fate determination (GO:0048664)2.61245834
98positive regulation of DNA-dependent DNA replication (GO:2000105)2.61153535
99mitochondrial respiratory chain complex assembly (GO:0033108)2.60168803
100anterograde synaptic vesicle transport (GO:0048490)2.59716318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.17638384
2ZNF274_21170338_ChIP-Seq_K562_Hela3.36188910
3EZH2_22144423_ChIP-Seq_EOC_Human3.35969516
4VDR_22108803_ChIP-Seq_LS180_Human2.99422829
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.80068333
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71926890
7GBX2_23144817_ChIP-Seq_PC3_Human2.58406150
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.55820112
9FUS_26573619_Chip-Seq_HEK293_Human2.47180466
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42963971
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.42929054
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.25385824
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.19422920
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19422920
15PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.17962645
16P300_19829295_ChIP-Seq_ESCs_Human2.16631990
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98038925
18IGF1R_20145208_ChIP-Seq_DFB_Human1.94559047
19EWS_26573619_Chip-Seq_HEK293_Human1.88944508
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.77197816
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76016253
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75280516
23TP53_16413492_ChIP-PET_HCT116_Human1.65565081
24SMAD3_21741376_ChIP-Seq_EPCs_Human1.64459257
25PRDM14_20953172_ChIP-Seq_ESCs_Human1.63864554
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56891546
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54448382
28SMAD4_21799915_ChIP-Seq_A2780_Human1.54292194
29BCAT_22108803_ChIP-Seq_LS180_Human1.53455859
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50523381
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50437742
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47707746
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46311508
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45356953
35TAF15_26573619_Chip-Seq_HEK293_Human1.44601926
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43644995
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.43038664
38RNF2_27304074_Chip-Seq_NSC_Mouse1.41287536
39RUNX2_22187159_ChIP-Seq_PCA_Human1.40241218
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40110122
41REST_21632747_ChIP-Seq_MESCs_Mouse1.38640386
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37864398
43TP53_18474530_ChIP-ChIP_U2OS_Human1.36588356
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35708618
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35645082
46STAT3_23295773_ChIP-Seq_U87_Human1.35505025
47TCF4_22108803_ChIP-Seq_LS180_Human1.34686464
48AR_21572438_ChIP-Seq_LNCaP_Human1.34092245
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34049495
50AR_25329375_ChIP-Seq_VCAP_Human1.33806158
51RXR_22108803_ChIP-Seq_LS180_Human1.33786944
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.31881022
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31454186
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29895091
55TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28662760
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28553502
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.26780865
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26260212
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24801494
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.18356689
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17899076
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.17132262
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14850416
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.14150422
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.12176555
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11794793
67P53_22387025_ChIP-Seq_ESCs_Mouse1.11475718
68TAL1_26923725_Chip-Seq_HPCs_Mouse1.11460882
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.11213835
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10285139
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09971330
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.09859668
73SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.09587198
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.09380235
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09350881
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.08947800
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08568204
78CBP_20019798_ChIP-Seq_JUKART_Human1.08568204
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08514510
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.08131106
81TCF4_23295773_ChIP-Seq_U87_Human1.07804254
82GF1B_26923725_Chip-Seq_HPCs_Mouse1.06556152
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.06503930
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.06223825
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05777809
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.04374552
87TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04031812
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04003147
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04003147
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.03850292
91NCOR_22424771_ChIP-Seq_293T_Human1.03397607
92JUN_21703547_ChIP-Seq_K562_Human1.02031448
93ER_23166858_ChIP-Seq_MCF-7_Human1.01732777
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01207245
95CMYC_18555785_Chip-Seq_ESCs_Mouse0.99505142
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99176704
97POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.97597836
98TP53_22573176_ChIP-Seq_HFKS_Human0.96579932
99SMAD_19615063_ChIP-ChIP_OVARY_Human0.96561804
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96212575

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology5.59109586
2MP0003878_abnormal_ear_physiology4.63306029
3MP0005377_hearing/vestibular/ear_phenot4.63306029
4MP0010030_abnormal_orbit_morphology4.31291125
5MP0006292_abnormal_olfactory_placode3.83543597
6MP0000372_irregular_coat_pigmentation3.47231912
7MP0004133_heterotaxia3.07731805
8MP0005075_abnormal_melanosome_morpholog2.81306557
9MP0003136_yellow_coat_color2.71712991
10MP0008789_abnormal_olfactory_epithelium2.63984128
11MP0004885_abnormal_endolymph2.57262965
12MP0000778_abnormal_nervous_system2.49707827
13MP0003221_abnormal_cardiomyocyte_apopto2.32134045
14MP0000569_abnormal_digit_pigmentation2.16377228
15MP0001299_abnormal_eye_distance/2.09376481
16MP0002234_abnormal_pharynx_morphology2.06213748
17MP0000015_abnormal_ear_pigmentation2.05515561
18MP0005171_absent_coat_pigmentation1.98733936
19MP0005499_abnormal_olfactory_system1.97745406
20MP0005394_taste/olfaction_phenotype1.97745406
21MP0003137_abnormal_impulse_conducting1.90994711
22MP0002938_white_spotting1.86634663
23MP0001545_abnormal_hematopoietic_system1.72856542
24MP0005397_hematopoietic_system_phenotyp1.72856542
25MP0001324_abnormal_eye_pigmentation1.72468612
26MP0000631_abnormal_neuroendocrine_gland1.64239943
27MP0008872_abnormal_physiological_respon1.61808309
28MP0003880_abnormal_central_pattern1.60092622
29MP0005408_hypopigmentation1.57679417
30MP0000371_diluted_coat_color1.54247041
31MP0002095_abnormal_skin_pigmentation1.48894700
32MP0005197_abnormal_uvea_morphology1.47254577
33MP0000534_abnormal_ureter_morphology1.46409844
34MP0003755_abnormal_palate_morphology1.42048688
35MP0001984_abnormal_olfaction1.41377185
36MP0008877_abnormal_DNA_methylation1.39732505
37MP0001286_abnormal_eye_development1.29560265
38MP0005423_abnormal_somatic_nervous1.25429024
39MP0003186_abnormal_redox_activity1.24458474
40MP0003787_abnormal_imprinting1.21163072
41MP0002184_abnormal_innervation1.16181830
42MP0001293_anophthalmia1.09637178
43MP0005195_abnormal_posterior_eye1.08196185
44MP0002233_abnormal_nose_morphology1.04017661
45MP0000955_abnormal_spinal_cord1.03686167
46MP0005451_abnormal_body_composition1.02554685
47MP0000470_abnormal_stomach_morphology1.01177677
48MP0002653_abnormal_ependyma_morphology1.00835962
49MP0005386_behavior/neurological_phenoty1.00318395
50MP0004924_abnormal_behavior1.00318395
51MP0005551_abnormal_eye_electrophysiolog1.00014002
52MP0004859_abnormal_synaptic_plasticity0.99576346
53MP0003942_abnormal_urinary_system0.99529142
54MP0009053_abnormal_anal_canal0.99214576
55MP0003635_abnormal_synaptic_transmissio0.99016106
56MP0008057_abnormal_DNA_replication0.97991976
57MP0001177_atelectasis0.97633935
58MP0002092_abnormal_eye_morphology0.97188628
59MP0003718_maternal_effect0.96717048
60MP0003385_abnormal_body_wall0.96269974
61MP0004085_abnormal_heartbeat0.96067387
62MP0002822_catalepsy0.93955934
63MP0005391_vision/eye_phenotype0.92589471
64MP0002752_abnormal_somatic_nervous0.91364284
65MP0001664_abnormal_digestion0.90912877
66MP0000049_abnormal_middle_ear0.90182493
67MP0004742_abnormal_vestibular_system0.89189928
68MP0009745_abnormal_behavioral_response0.88768038
69MP0005174_abnormal_tail_pigmentation0.88637737
70MP0002089_abnormal_postnatal_growth/wei0.87023447
71MP0002837_dystrophic_cardiac_calcinosis0.85991511
72MP0003861_abnormal_nervous_system0.85324402
73MP0002882_abnormal_neuron_morphology0.83023771
74MP0003938_abnormal_ear_development0.81281162
75MP0005220_abnormal_exocrine_pancreas0.78156069
76MP0002733_abnormal_thermal_nociception0.78088976
77MP0002272_abnormal_nervous_system0.78066401
78MP0002736_abnormal_nociception_after0.77917483
79MP0006072_abnormal_retinal_apoptosis0.77596255
80MP0003121_genomic_imprinting0.76865135
81MP0005253_abnormal_eye_physiology0.76224315
82MP0003122_maternal_imprinting0.74964984
83MP0000026_abnormal_inner_ear0.74467765
84MP0001963_abnormal_hearing_physiology0.73493719
85MP0004381_abnormal_hair_follicle0.72967944
86MP0003656_abnormal_erythrocyte_physiolo0.72518256
87MP0002751_abnormal_autonomic_nervous0.72299860
88MP0001486_abnormal_startle_reflex0.70303506
89MP0009379_abnormal_foot_pigmentation0.67732895
90MP0008775_abnormal_heart_ventricle0.67113290
91MP0001485_abnormal_pinna_reflex0.67083762
92MP0002735_abnormal_chemical_nociception0.67026525
93MP0000516_abnormal_urinary_system0.66518207
94MP0005367_renal/urinary_system_phenotyp0.66518207
95MP0002064_seizures0.66233777
96MP0002063_abnormal_learning/memory/cond0.65491141
97MP0004142_abnormal_muscle_tone0.64962095
98MP0002152_abnormal_brain_morphology0.64768858
99MP0001986_abnormal_taste_sensitivity0.63912436
100MP0001968_abnormal_touch/_nociception0.63867957

Predicted human phenotypes

RankGene SetZ-score
1Anterior segment dysgenesis (HP:0007700)6.98665512
2Neoplasm of the adrenal gland (HP:0100631)6.57222228
3Iris hypopigmentation (HP:0007730)6.12280171
4Hypoplasia of the iris (HP:0007676)4.31041981
5Ocular albinism (HP:0001107)4.17783165
6Focal motor seizures (HP:0011153)4.13177788
7Intestinal atresia (HP:0011100)3.73371806
8Anal stenosis (HP:0002025)3.57845532
9Focal seizures (HP:0007359)3.30913674
10Pancreatic fibrosis (HP:0100732)3.26345395
11Megalocornea (HP:0000485)3.20961408
12Gastrointestinal atresia (HP:0002589)3.10572289
13Melanoma (HP:0002861)3.08402626
14Tetraplegia (HP:0002445)3.06630922
15Growth hormone deficiency (HP:0000824)3.03666774
16Molar tooth sign on MRI (HP:0002419)2.87442937
17Abnormality of midbrain morphology (HP:0002418)2.87442937
18Decreased subcutaneous fat (HP:0001002)2.78983805
19Metaphyseal dysplasia (HP:0100255)2.78962582
20Short chin (HP:0000331)2.71675375
21Acute necrotizing encephalopathy (HP:0006965)2.66979440
22Steatorrhea (HP:0002570)2.65942333
23Abnormality of pyrimidine metabolism (HP:0004353)2.62342217
24Optic nerve hypoplasia (HP:0000609)2.61816609
25Anal atresia (HP:0002023)2.60644495
26Absent rod-and cone-mediated responses on ERG (HP:0007688)2.59557228
27Aplasia/Hypoplasia of the lens (HP:0008063)2.52327747
28Progressive macrocephaly (HP:0004481)2.46197281
29Neoplasm of the lung (HP:0100526)2.44933615
30Abnormality of the anterior chamber (HP:0000593)2.41527226
31Medial flaring of the eyebrow (HP:0010747)2.38705843
32Dialeptic seizures (HP:0011146)2.37028913
33Abnormality of subcutaneous fat tissue (HP:0001001)2.36030912
34Congenital stationary night blindness (HP:0007642)2.30431241
35Neoplasm of the colon (HP:0100273)2.29260942
36Rectovaginal fistula (HP:0000143)2.28152557
37Rectal fistula (HP:0100590)2.28152557
38Renal hypoplasia (HP:0000089)2.25958813
39Acute encephalopathy (HP:0006846)2.25046505
40Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.25022681
41Abnormal hair whorl (HP:0010721)2.24759105
42Pachygyria (HP:0001302)2.24738841
43Congenital glaucoma (HP:0001087)2.24343141
44Abnormality of the line of Schwalbe (HP:0008048)2.22813522
45Genital tract atresia (HP:0001827)2.19894872
46Abnormal mitochondria in muscle tissue (HP:0008316)2.19320821
47Ulnar claw (HP:0001178)2.18855361
48Inability to walk (HP:0002540)2.18699299
49Atonic seizures (HP:0010819)2.16915379
50Maternal diabetes (HP:0009800)2.15977927
51Neoplasm of the respiratory system (HP:0100606)2.15226500
52Preaxial hand polydactyly (HP:0001177)2.09887247
53Posterior embryotoxon (HP:0000627)2.09253011
54Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.09245443
55Gait imbalance (HP:0002141)2.08563587
56Mitochondrial inheritance (HP:0001427)2.08104021
57Retinal dysplasia (HP:0007973)2.04440801
58Nephronophthisis (HP:0000090)2.02915028
59Drooling (HP:0002307)2.02756941
60Increased corneal curvature (HP:0100692)2.02745088
61Keratoconus (HP:0000563)2.02745088
62Megalencephaly (HP:0001355)2.02313653
63Median cleft lip (HP:0000161)2.01914607
64Reticulocytopenia (HP:0001896)2.01804583
65Fat malabsorption (HP:0002630)2.00600831
66Congenital primary aphakia (HP:0007707)2.00286685
67Neoplasm of the adrenal cortex (HP:0100641)11.8131211
68Abnormality of the pupil (HP:0000615)1.97483139
69Abnormal rod and cone electroretinograms (HP:0008323)1.97422059
70Gaze-evoked nystagmus (HP:0000640)1.97096197
71Amblyopia (HP:0000646)1.94243359
72Postaxial foot polydactyly (HP:0001830)1.92086435
73Decreased central vision (HP:0007663)1.90813937
74Cerebral hypomyelination (HP:0006808)1.90244654
75Abnormality of cells of the erythroid lineage (HP:0012130)1.90049849
76Freckling (HP:0001480)1.89569459
77Absence seizures (HP:0002121)1.86159170
78Excessive salivation (HP:0003781)1.86125772
79True hermaphroditism (HP:0010459)1.85983595
80Scotoma (HP:0000575)1.83295887
81Pancreatic cysts (HP:0001737)1.82754352
82Partial duplication of thumb phalanx (HP:0009944)1.82049414
83Vaginal fistula (HP:0004320)1.81444354
84Sclerocornea (HP:0000647)1.80806159
85White forelock (HP:0002211)1.79681969
86Increased CSF lactate (HP:0002490)1.79539576
87Prominent supraorbital ridges (HP:0000336)1.77768252
88Poor coordination (HP:0002370)1.76854014
89Adrenal hypoplasia (HP:0000835)1.76836714
90Hyperglycinemia (HP:0002154)1.75583144
91Syncope (HP:0001279)1.74430803
92Aplasia/Hypoplasia of the tibia (HP:0005772)1.73702074
93Short tibia (HP:0005736)1.73424669
94Generalized tonic-clonic seizures (HP:0002069)1.72652175
95Nephrogenic diabetes insipidus (HP:0009806)1.71678773
96Patchy hypopigmentation of hair (HP:0011365)1.71088329
97Birth length less than 3rd percentile (HP:0003561)1.70809092
98Abnormality of lateral ventricle (HP:0030047)1.69874842
99Abnormality of the nasal septum (HP:0000419)1.69482340
100Intestinal fistula (HP:0100819)1.69298352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYRO34.48742581
2TRIM284.38288755
3DAPK34.24260417
4FRK3.87659497
5MARK13.40422737
6PIM12.62393773
7EPHA42.44854850
8ERBB32.38513563
9BMPR1B2.18558290
10BCR2.10470925
11MAP4K22.05421880
12CASK1.95973044
13CDK191.85057983
14DYRK21.76113472
15ACVR1B1.71610579
16PINK11.64034570
17WEE11.62243031
18CSNK1G11.57750578
19STK391.56951927
20FGFR21.48973819
21BMPR21.44819108
22RPS6KB11.43642707
23CSNK1D1.33091077
24GRK11.30871020
25PLK21.30518491
26CSNK1G21.29512449
27PLK41.29225146
28WNK41.23936726
29PRKCZ1.14826839
30ADRBK11.13547882
31WNK31.10338174
32AKT21.07262234
33CSNK1G31.06806594
34PLK11.05036235
35TGFBR21.02682964
36ADRBK21.02235718
37NUAK10.99760406
38MAPKAPK20.97905657
39MAPK130.97693350
40OXSR10.93795670
41PAK30.87251645
42CAMK1D0.86097107
43CAMKK20.85245060
44DAPK20.83660956
45MAP2K70.81473752
46CAMK40.74707767
47CSNK1A1L0.73652912
48TIE10.73537824
49GRK50.71797348
50MAP3K40.71620349
51ATR0.71165232
52FES0.68496590
53ABL10.67697406
54ATM0.64273989
55CSNK1A10.63831415
56SGK2230.62485046
57SGK4940.62485046
58CDC70.61434895
59PRKCD0.60681562
60STK38L0.60107344
61PIK3CA0.58024822
62PRKDC0.57354732
63SGK20.56508164
64ZAK0.56312515
65VRK20.55992744
66PRKCG0.55954047
67MINK10.54978851
68PRKCE0.54633683
69DYRK30.54053876
70CHUK0.53268357
71EIF2AK30.53110517
72ILK0.51974545
73CLK10.51573803
74STK110.51407348
75KDR0.51134880
76LRRK20.51056388
77CDK50.50777235
78CAMK1G0.49504277
79PRKACA0.49503933
80NTRK20.49013403
81YES10.48141035
82CAMK10.47013924
83STK30.46185567
84STK380.44751859
85GSK3B0.44072533
86CHEK20.43781691
87AKT10.43380453
88DYRK1A0.42944595
89SIK20.39737979
90CAMK2A0.39343727
91MKNK20.39061689
92PRKCB0.38989877
93RPS6KA30.37976901
94MARK20.37826953
95FER0.35697655
96PRKCI0.35072624
97CDK20.34794712
98PRKAA10.34676300
99TEC0.34222122
100PRKACG0.34050851

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.18904200
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.77459775
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.70259659
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.63183191
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.60537284
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.46551982
7Linoleic acid metabolism_Homo sapiens_hsa005912.27403665
8Dorso-ventral axis formation_Homo sapiens_hsa043202.21667747
9Collecting duct acid secretion_Homo sapiens_hsa049662.18297974
10p53 signaling pathway_Homo sapiens_hsa041152.08932043
11Phototransduction_Homo sapiens_hsa047441.99855917
12Protein export_Homo sapiens_hsa030601.98335758
13Oxidative phosphorylation_Homo sapiens_hsa001901.97439321
14Bladder cancer_Homo sapiens_hsa052191.91495960
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85450777
16Nicotine addiction_Homo sapiens_hsa050331.83020653
17Tyrosine metabolism_Homo sapiens_hsa003501.72165634
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71906947
19Melanoma_Homo sapiens_hsa052181.64100300
20Taste transduction_Homo sapiens_hsa047421.57425194
21Synaptic vesicle cycle_Homo sapiens_hsa047211.54515039
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49851997
23Parkinsons disease_Homo sapiens_hsa050121.47099205
24Basal transcription factors_Homo sapiens_hsa030221.46857874
25RNA degradation_Homo sapiens_hsa030181.42852065
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41481686
27Glioma_Homo sapiens_hsa052141.39666806
28Fanconi anemia pathway_Homo sapiens_hsa034601.38198678
29Caffeine metabolism_Homo sapiens_hsa002321.37825819
30RNA polymerase_Homo sapiens_hsa030201.33690182
31Ether lipid metabolism_Homo sapiens_hsa005651.31746840
32beta-Alanine metabolism_Homo sapiens_hsa004101.30253956
33Homologous recombination_Homo sapiens_hsa034401.27603909
34Non-homologous end-joining_Homo sapiens_hsa034501.23647791
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23099062
36Tryptophan metabolism_Homo sapiens_hsa003801.21690030
37Serotonergic synapse_Homo sapiens_hsa047261.21148786
38Steroid biosynthesis_Homo sapiens_hsa001001.14485094
39Alzheimers disease_Homo sapiens_hsa050101.14478659
40Morphine addiction_Homo sapiens_hsa050321.12493313
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.12201246
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11010891
43Axon guidance_Homo sapiens_hsa043601.05439727
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04403257
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03312563
46Huntingtons disease_Homo sapiens_hsa050161.03100364
47Histidine metabolism_Homo sapiens_hsa003401.01190484
48Ribosome_Homo sapiens_hsa030100.96097108
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93314282
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.90356239
51FoxO signaling pathway_Homo sapiens_hsa040680.90297954
52Glutamatergic synapse_Homo sapiens_hsa047240.90196598
53Regulation of autophagy_Homo sapiens_hsa041400.89930502
54Peroxisome_Homo sapiens_hsa041460.87853565
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87603547
56Arachidonic acid metabolism_Homo sapiens_hsa005900.87167718
57Long-term depression_Homo sapiens_hsa047300.85295903
58RNA transport_Homo sapiens_hsa030130.84530877
59Olfactory transduction_Homo sapiens_hsa047400.83073451
60Prostate cancer_Homo sapiens_hsa052150.80809921
61Vibrio cholerae infection_Homo sapiens_hsa051100.76756256
62Salivary secretion_Homo sapiens_hsa049700.76098300
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73356413
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73054695
65Fat digestion and absorption_Homo sapiens_hsa049750.70008013
66Retinol metabolism_Homo sapiens_hsa008300.69850448
67Ovarian steroidogenesis_Homo sapiens_hsa049130.68491816
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67538351
69GABAergic synapse_Homo sapiens_hsa047270.65962007
70Dopaminergic synapse_Homo sapiens_hsa047280.65182525
71Insulin secretion_Homo sapiens_hsa049110.65038841
72Cell cycle_Homo sapiens_hsa041100.63122013
73Chemical carcinogenesis_Homo sapiens_hsa052040.62983227
74Cholinergic synapse_Homo sapiens_hsa047250.61762051
75Cardiac muscle contraction_Homo sapiens_hsa042600.61441981
76TGF-beta signaling pathway_Homo sapiens_hsa043500.58727432
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57902529
78Glycerolipid metabolism_Homo sapiens_hsa005610.55309036
79Melanogenesis_Homo sapiens_hsa049160.54491952
80Pancreatic secretion_Homo sapiens_hsa049720.53783953
81Circadian entrainment_Homo sapiens_hsa047130.53029522
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.52704538
83Cocaine addiction_Homo sapiens_hsa050300.52461893
84Calcium signaling pathway_Homo sapiens_hsa040200.50848182
85Pyrimidine metabolism_Homo sapiens_hsa002400.50556870
86Gastric acid secretion_Homo sapiens_hsa049710.49144310
87Nitrogen metabolism_Homo sapiens_hsa009100.48237357
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47904089
89Amphetamine addiction_Homo sapiens_hsa050310.47853226
90Pyruvate metabolism_Homo sapiens_hsa006200.44373270
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41439779
92Vitamin digestion and absorption_Homo sapiens_hsa049770.40236206
93mTOR signaling pathway_Homo sapiens_hsa041500.38574542
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38261432
95Long-term potentiation_Homo sapiens_hsa047200.38049716
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35552790
97Wnt signaling pathway_Homo sapiens_hsa043100.35519779
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35458182
99One carbon pool by folate_Homo sapiens_hsa006700.33161743
100Chronic myeloid leukemia_Homo sapiens_hsa052200.30109374

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