RPL31P59

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.15036724
2viral transcription (GO:0019083)6.02223158
3translational termination (GO:0006415)5.72402956
4icosanoid secretion (GO:0032309)5.20575310
5arachidonic acid secretion (GO:0050482)5.20575310
6cAMP catabolic process (GO:0006198)5.10123703
7translational elongation (GO:0006414)4.85308774
8mitochondrion transport along microtubule (GO:0047497)4.82086204
9establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.82086204
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.73871083
11cotranslational protein targeting to membrane (GO:0006613)4.64180647
12establishment of protein localization to endoplasmic reticulum (GO:0072599)4.55762050
13protein targeting to ER (GO:0045047)4.55286312
14pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.52218348
15positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.50568236
16mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.50568236
17pyrimidine nucleotide catabolic process (GO:0006244)4.50242625
18establishment of mitochondrion localization (GO:0051654)4.49366648
19cellular protein complex disassembly (GO:0043624)4.32836848
20icosanoid transport (GO:0071715)4.32220005
21fatty acid derivative transport (GO:1901571)4.32220005
22cyclic nucleotide catabolic process (GO:0009214)4.29878464
23protein localization to endoplasmic reticulum (GO:0070972)4.24688724
24viral life cycle (GO:0019058)4.12559487
25respiratory chain complex IV assembly (GO:0008535)4.11585494
26positive regulation of growth hormone secretion (GO:0060124)4.11005217
27regulation of short-term neuronal synaptic plasticity (GO:0048172)4.08657942
28indole-containing compound catabolic process (GO:0042436)4.01573850
29indolalkylamine catabolic process (GO:0046218)4.01573850
30tryptophan catabolic process (GO:0006569)4.01573850
31ribosomal small subunit biogenesis (GO:0042274)4.01050940
32maturation of SSU-rRNA (GO:0030490)4.00607314
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.99706302
34platelet dense granule organization (GO:0060155)3.96423486
35regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.83948775
36translational initiation (GO:0006413)3.83110772
37hepatocyte differentiation (GO:0070365)3.79636790
38protein complex disassembly (GO:0043241)3.76258740
39homocysteine metabolic process (GO:0050667)3.66507268
40deoxyribose phosphate catabolic process (GO:0046386)3.65515128
41viral mRNA export from host cell nucleus (GO:0046784)3.64948153
42macromolecular complex disassembly (GO:0032984)3.61628645
43DNA deamination (GO:0045006)3.56758617
44protein prenylation (GO:0018342)3.56349016
45prenylation (GO:0097354)3.56349016
46auditory behavior (GO:0031223)3.51008965
47regulation of relaxation of muscle (GO:1901077)3.50096560
48cytochrome complex assembly (GO:0017004)3.47904571
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.47383207
50energy coupled proton transport, down electrochemical gradient (GO:0015985)3.47332339
51ATP synthesis coupled proton transport (GO:0015986)3.47332339
52activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.45727050
53ribosomal large subunit biogenesis (GO:0042273)3.44916799
54regulation of hypersensitivity (GO:0002883)3.42007730
55negative regulation of chemokine production (GO:0032682)3.39238663
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.37214191
57chaperone-mediated protein transport (GO:0072321)3.30530258
58deoxyribonucleotide catabolic process (GO:0009264)3.30368766
59negative regulation of mast cell activation (GO:0033004)3.27746155
60translation (GO:0006412)3.26742230
61immunoglobulin mediated immune response (GO:0016064)3.26288638
62regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.22484712
63negative regulation of myeloid cell apoptotic process (GO:0033033)3.20952394
64regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.20206516
65kynurenine metabolic process (GO:0070189)3.18729465
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.16889965
67G-protein coupled receptor internalization (GO:0002031)3.14012404
68regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.10868926
69regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.10868926
70regulation of non-canonical Wnt signaling pathway (GO:2000050)3.09645010
71cellular response to epinephrine stimulus (GO:0071872)3.08914466
72peristalsis (GO:0030432)3.08466202
73negative regulation of cytosolic calcium ion concentration (GO:0051481)3.07501691
74substrate-independent telencephalic tangential migration (GO:0021826)3.07490515
75substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.07490515
76phenol-containing compound catabolic process (GO:0019336)3.07348681
77respiratory electron transport chain (GO:0022904)3.05912360
78protein targeting to membrane (GO:0006612)3.02853973
79electron transport chain (GO:0022900)3.01796741
80response to epinephrine (GO:0071871)2.98097872
81hypothalamus development (GO:0021854)2.96090945
82DNA double-strand break processing (GO:0000729)2.95668459
83behavioral response to ethanol (GO:0048149)2.93281502
84tryptophan metabolic process (GO:0006568)2.89792851
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86852275
86negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.86594765
87regulation of voltage-gated calcium channel activity (GO:1901385)2.85268814
88regulation of growth hormone secretion (GO:0060123)2.83825787
89negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.82496748
90response to acidic pH (GO:0010447)2.78855995
91nuclear-transcribed mRNA catabolic process (GO:0000956)2.78846522
92indolalkylamine metabolic process (GO:0006586)2.76671187
93regulation of cardiac muscle cell contraction (GO:0086004)2.76231836
94regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.75497863
95synaptic transmission, dopaminergic (GO:0001963)2.75003182
96replication fork processing (GO:0031297)2.71334309
97ncRNA catabolic process (GO:0034661)2.70748224
98protein heterotetramerization (GO:0051290)2.66848743
99phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.65613463
100positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.64554992

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.25380575
2EZH2_22144423_ChIP-Seq_EOC_Human5.23309637
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse5.14939942
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.59124348
5VDR_22108803_ChIP-Seq_LS180_Human4.02779487
6E2F7_22180533_ChIP-Seq_HELA_Human3.46874875
7ZNF263_19887448_ChIP-Seq_K562_Human3.27905173
8CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.14566184
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76659197
10ESR1_15608294_ChIP-ChIP_MCF-7_Human2.61102765
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.34282547
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30047783
13FUS_26573619_Chip-Seq_HEK293_Human2.23967421
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.21315946
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.16298758
16RNF2_27304074_Chip-Seq_NSC_Mouse2.03322495
17ZNF274_21170338_ChIP-Seq_K562_Hela1.94044044
18KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.86027604
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.83559092
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79288525
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77082680
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.74396898
23EWS_26573619_Chip-Seq_HEK293_Human1.69471703
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69320502
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.67219184
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63027915
27MYC_18940864_ChIP-ChIP_HL60_Human1.55645524
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54007519
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52644453
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.52642159
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42183323
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41120226
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40774443
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39914691
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.39112958
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.36477001
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.34999147
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34692586
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34692586
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33797514
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32707091
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32076742
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31134435
44TP53_22573176_ChIP-Seq_HFKS_Human1.30634108
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.29483711
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28653409
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27302808
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27141148
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27013142
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22598965
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21874582
52P300_19829295_ChIP-Seq_ESCs_Human1.18030223
53RXR_22108803_ChIP-Seq_LS180_Human1.17162958
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.17092963
55VDR_23849224_ChIP-Seq_CD4+_Human1.16634069
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16317926
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.16281061
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14347922
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.13726711
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11985701
61ELK1_19687146_ChIP-ChIP_HELA_Human1.07980403
62TTF2_22483619_ChIP-Seq_HELA_Human1.05113047
63REST_21632747_ChIP-Seq_MESCs_Mouse1.05007906
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04483212
65SOX2_19829295_ChIP-Seq_ESCs_Human1.03731627
66NANOG_19829295_ChIP-Seq_ESCs_Human1.03731627
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01922812
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.00149701
69TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97174595
70SOX2_16153702_ChIP-ChIP_HESCs_Human0.96196495
71HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96054361
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95591069
73P53_21459846_ChIP-Seq_SAOS-2_Human0.94951662
74CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94619398
75RAC3_21632823_ChIP-Seq_H3396_Human0.93542147
76ETS1_20019798_ChIP-Seq_JURKAT_Human0.92602502
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91956532
78CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89509160
79BP1_19119308_ChIP-ChIP_Hs578T_Human0.89160626
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.89061069
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88691364
82SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88685393
83JUN_21703547_ChIP-Seq_K562_Human0.86921177
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84565887
85ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84120095
86POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83384404
87YY1_21170310_ChIP-Seq_MESCs_Mouse0.83055765
88TAF2_19829295_ChIP-Seq_ESCs_Human0.82605868
89LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80799405
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80504288
91RING1B_27294783_Chip-Seq_ESCs_Mouse0.80220441
92ERG_21242973_ChIP-ChIP_JURKAT_Human0.79878982
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.79458900
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.78738894
95NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77000092
96NANOG_20526341_ChIP-Seq_ESCs_Human0.74688762
97TAF15_26573619_Chip-Seq_HEK293_Human0.74560447
98MYC_19030024_ChIP-ChIP_MESCs_Mouse0.74030075
99TCF4_22108803_ChIP-Seq_LS180_Human0.73477038
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.71948201

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.85201091
2MP0001188_hyperpigmentation4.71505424
3MP0009379_abnormal_foot_pigmentation4.15378856
4MP0000537_abnormal_urethra_morphology3.88671211
5MP0005083_abnormal_biliary_tract3.32937002
6MP0003183_abnormal_peptide_metabolism3.12645442
7MP0005409_darkened_coat_color2.84096317
8MP0009053_abnormal_anal_canal2.61164228
9MP0005367_renal/urinary_system_phenotyp2.56302535
10MP0000516_abnormal_urinary_system2.56302535
11MP0003136_yellow_coat_color2.51745367
12MP0005646_abnormal_pituitary_gland2.29919784
13MP0000569_abnormal_digit_pigmentation2.23333651
14MP0002163_abnormal_gland_morphology2.21820356
15MP0000427_abnormal_hair_cycle2.20708653
16MP0008058_abnormal_DNA_repair2.19696877
17MP0006276_abnormal_autonomic_nervous2.19150943
18MP0005645_abnormal_hypothalamus_physiol2.07659723
19MP0009780_abnormal_chondrocyte_physiolo2.02663783
20MP0003315_abnormal_perineum_morphology1.98529854
21MP0003122_maternal_imprinting1.94332238
22MP0000383_abnormal_hair_follicle1.90898590
23MP0002009_preneoplasia1.75800739
24MP0005551_abnormal_eye_electrophysiolog1.63515219
25MP0001346_abnormal_lacrimal_gland1.60044595
26MP0004019_abnormal_vitamin_homeostasis1.58790267
27MP0005085_abnormal_gallbladder_physiolo1.54920231
28MP0003121_genomic_imprinting1.50803632
29MP0009250_abnormal_appendicular_skeleto1.49997351
30MP0009764_decreased_sensitivity_to1.48709779
31MP0003880_abnormal_central_pattern1.42557306
32MP0001529_abnormal_vocalization1.36574522
33MP0002876_abnormal_thyroid_physiology1.35583066
34MP0002638_abnormal_pupillary_reflex1.33011544
35MP0002282_abnormal_trachea_morphology1.32407570
36MP0004142_abnormal_muscle_tone1.25529313
37MP0002233_abnormal_nose_morphology1.24957768
38MP0003937_abnormal_limbs/digits/tail_de1.24679895
39MP0002697_abnormal_eye_size1.24337093
40MP0006072_abnormal_retinal_apoptosis1.23081274
41MP0005174_abnormal_tail_pigmentation1.20699793
42MP0001835_abnormal_antigen_presentation1.17280652
43MP0002160_abnormal_reproductive_system1.16773184
44MP0008995_early_reproductive_senescence1.15068579
45MP0000631_abnormal_neuroendocrine_gland1.13293372
46MP0006292_abnormal_olfactory_placode1.12103133
47MP0002095_abnormal_skin_pigmentation1.08245906
48MP0001905_abnormal_dopamine_level1.08217948
49MP0005195_abnormal_posterior_eye1.07573166
50MP0000647_abnormal_sebaceous_gland1.07145470
51MP0009046_muscle_twitch1.07094124
52MP0003567_abnormal_fetal_cardiomyocyte1.03807042
53MP0005253_abnormal_eye_physiology0.99704773
54MP0010094_abnormal_chromosome_stability0.99319850
55MP0001286_abnormal_eye_development0.98729403
56MP0000639_abnormal_adrenal_gland0.98598803
57MP0005379_endocrine/exocrine_gland_phen0.95866194
58MP0002272_abnormal_nervous_system0.95402157
59MP0002938_white_spotting0.95048777
60MP0004133_heterotaxia0.94358076
61MP0010030_abnormal_orbit_morphology0.94305092
62MP0005670_abnormal_white_adipose0.93123563
63MP0003938_abnormal_ear_development0.91172710
64MP0000049_abnormal_middle_ear0.88963437
65MP0001986_abnormal_taste_sensitivity0.88562484
66MP0002109_abnormal_limb_morphology0.87200203
67MP0001486_abnormal_startle_reflex0.86276470
68MP0010678_abnormal_skin_adnexa0.85834750
69MP0005187_abnormal_penis_morphology0.85294215
70MP0008770_decreased_survivor_rate0.84160338
71MP0001145_abnormal_male_reproductive0.83387781
72MP0002098_abnormal_vibrissa_morphology0.82655017
73MP0000015_abnormal_ear_pigmentation0.82414025
74MP0005389_reproductive_system_phenotype0.80910506
75MP0005423_abnormal_somatic_nervous0.80560693
76MP0008789_abnormal_olfactory_epithelium0.79818397
77MP0002115_abnormal_skeleton_extremities0.78309934
78MP0006036_abnormal_mitochondrial_physio0.77190967
79MP0002111_abnormal_tail_morphology0.76810141
80MP0001119_abnormal_female_reproductive0.74161862
81MP0001293_anophthalmia0.74117398
82MP0002210_abnormal_sex_determination0.71488509
83MP0008872_abnormal_physiological_respon0.71316890
84MP0005220_abnormal_exocrine_pancreas0.69921056
85MP0002557_abnormal_social/conspecific_i0.69901409
86MP0000653_abnormal_sex_gland0.68697564
87MP0004885_abnormal_endolymph0.68485540
88MP0002837_dystrophic_cardiac_calcinosis0.68106997
89MP0001502_abnormal_circadian_rhythm0.68043555
90MP0003119_abnormal_digestive_system0.67771929
91MP0001664_abnormal_digestion0.66011958
92MP0000428_abnormal_craniofacial_morphol0.65468092
93MP0003123_paternal_imprinting0.65075186
94MP0004084_abnormal_cardiac_muscle0.65055134
95MP0003186_abnormal_redox_activity0.64434028
96MP0002752_abnormal_somatic_nervous0.64031297
97MP0005386_behavior/neurological_phenoty0.63398524
98MP0004924_abnormal_behavior0.63398524
99MP0001440_abnormal_grooming_behavior0.63163280
100MP0008775_abnormal_heart_ventricle0.63020396

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.97291646
2Abnormality of the phalanges of the 2nd finger (HP:0009541)4.44205327
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.38073019
4Absent/shortened dynein arms (HP:0200106)4.38073019
5Abnormality of the 2nd finger (HP:0004100)4.12710011
6Cerebellar dysplasia (HP:0007033)4.00518371
7Abnormality of DNA repair (HP:0003254)3.87636390
8Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.49544667
9Macrocytic anemia (HP:0001972)3.33684710
10Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.32575953
11Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.31331690
12Abnormality of cells of the erythroid lineage (HP:0012130)3.31293241
13Abnormality of the phalanges of the 5th finger (HP:0004213)3.18088005
14Alkalosis (HP:0001948)3.09469465
15Acute necrotizing encephalopathy (HP:0006965)2.98245621
16Metaphyseal dysplasia (HP:0100255)2.91220611
17Abnormality of the ischium (HP:0003174)2.87219803
18Entropion (HP:0000621)2.79252157
19Abnormal mitochondria in muscle tissue (HP:0008316)2.79088395
20Poor head control (HP:0002421)2.79039617
21Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78235816
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78235816
23Overlapping toe (HP:0001845)2.67087385
24Hypoplasia of the radius (HP:0002984)2.64303932
25Abnormal foot bone ossification (HP:0010675)2.63980091
26Short middle phalanx of the 5th finger (HP:0004220)2.56849313
27Oligodactyly (hands) (HP:0001180)2.50933430
28Calcaneovalgus deformity (HP:0001848)2.49666558
29Hypoplastic ischia (HP:0003175)2.48118301
30Cerebral edema (HP:0002181)2.47881161
31Anophthalmia (HP:0000528)2.47722373
32Poikiloderma (HP:0001029)2.47301902
33Increased CSF lactate (HP:0002490)2.44814536
34Septo-optic dysplasia (HP:0100842)2.41161263
35Rib fusion (HP:0000902)2.40485104
36Volvulus (HP:0002580)2.40069482
37Disproportionate short-trunk short stature (HP:0003521)2.38820382
38Abnormality of magnesium homeostasis (HP:0004921)2.36945410
39Pallor (HP:0000980)2.35312321
40Progressive macrocephaly (HP:0004481)2.31595955
41Type II lissencephaly (HP:0007260)2.30941742
42Hypomagnesemia (HP:0002917)2.26942085
43Myokymia (HP:0002411)2.25132948
44Acute encephalopathy (HP:0006846)2.24356017
45Mitochondrial inheritance (HP:0001427)2.21108974
46Supernumerary ribs (HP:0005815)2.20970568
47Abnormal number of erythroid precursors (HP:0012131)2.20760742
48Abnormal respiratory epithelium morphology (HP:0012253)2.18861016
49Abnormal respiratory motile cilium morphology (HP:0005938)2.18861016
50Short tibia (HP:0005736)2.18293201
51Deformed tarsal bones (HP:0008119)2.17490550
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16545800
53Forearm undergrowth (HP:0009821)2.14178983
54Polyuria (HP:0000103)2.13237330
55Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.11740891
56Ectopic kidney (HP:0000086)2.10798594
573-Methylglutaconic aciduria (HP:0003535)2.09203245
58Aplasia/Hypoplasia of the tibia (HP:0005772)2.08015602
59Supernumerary bones of the axial skeleton (HP:0009144)2.05467607
60Hypokinesia (HP:0002375)2.04535909
61Anencephaly (HP:0002323)2.02619564
62Oligodactyly (HP:0012165)2.02141970
63Abnormal drinking behavior (HP:0030082)2.00504104
64Polydipsia (HP:0001959)2.00504104
65Abnormality of renal excretion (HP:0011036)2.00416352
66Short 5th finger (HP:0009237)1.97346520
67Pancreatic fibrosis (HP:0100732)1.96237221
68Hypokalemic alkalosis (HP:0001949)1.95794870
69Morphological abnormality of the middle ear (HP:0008609)1.95307278
70Stenosis of the external auditory canal (HP:0000402)1.92759499
71Amblyopia (HP:0000646)1.90962547
72Protuberant abdomen (HP:0001538)1.90511791
73Vascular calcification (HP:0004934)1.88541923
74Tetany (HP:0001281)1.87065317
75Abnormal hemoglobin (HP:0011902)1.86384286
76Abnormal tarsal ossification (HP:0008369)1.85961750
77Chronic hepatic failure (HP:0100626)1.85751926
78Shawl scrotum (HP:0000049)1.81981593
79Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.81069053
80Keratitis (HP:0000491)1.80893337
81Increased circulating renin level (HP:0000848)1.80418216
82Abnormality of the middle phalanges of the toes (HP:0010183)1.80327983
83Short hallux (HP:0010109)1.80191076
84Myotonia (HP:0002486)1.79826054
85Growth hormone deficiency (HP:0000824)1.79431057
86Abnormal ciliary motility (HP:0012262)1.77872347
87Abnormal number of incisors (HP:0011064)1.77769477
88Abnormality of the renal cortex (HP:0011035)1.74418101
89Absent thumb (HP:0009777)1.73181663
90Aplasia/Hypoplasia of the spleen (HP:0010451)1.72691573
91Abnormality of the labia minora (HP:0012880)1.71638445
92Abnormal urine output (HP:0012590)1.70574336
93Abnormality of dental color (HP:0011073)1.69925235
94Ulnar deviation of finger (HP:0009465)1.68736982
95Abnormality of homocysteine metabolism (HP:0010919)1.68689038
96Homocystinuria (HP:0002156)1.68689038
97Pendular nystagmus (HP:0012043)1.68543895
98Hepatic necrosis (HP:0002605)1.68070915
99Congenital malformation of the right heart (HP:0011723)1.67325970
100Double outlet right ventricle (HP:0001719)1.67325970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK167.00883288
2PDK25.31268383
3MAP4K24.92536592
4WNK44.32373254
5BMPR23.02000285
6CDK82.98796828
7STK392.91407602
8MAP3K122.73947119
9BRSK22.05034528
10RIPK42.01796688
11CAMKK21.96641741
12OXSR11.88881397
13ILK1.74133388
14PINK11.73958040
15CDK191.73765857
16DYRK21.66645830
17ERBB31.44352134
18DAPK31.44346351
19TLK11.40361855
20PIK3CG1.30872475
21SIK21.28882659
22PRKD31.23867228
23BRSK11.21782605
24NEK11.05105412
25CDK41.00525547
26CASK0.99562074
27MYLK0.93627513
28TRPM70.93184716
29MAPK120.87860465
30TNIK0.84750038
31CCNB10.83773473
32ZAK0.79482448
33AURKB0.78356442
34GRK10.77781798
35MAPK130.76424558
36NEK60.75094452
37FLT30.72504801
38RPS6KA50.70480799
39WNK30.69757854
40CAMKK10.66463167
41PKN10.66090957
42PRKG10.63868288
43PASK0.63621645
44CSF1R0.61961227
45ABL20.61038122
46INSRR0.61030519
47CDC70.60743296
48PIM10.59624188
49PRKCG0.57591554
50MAPK70.56062579
51MST1R0.53340491
52STK110.53120011
53ADRBK20.52871965
54PHKG10.52749607
55PHKG20.52749607
56PRKACA0.52639413
57WEE10.51125263
58MKNK20.49827431
59MAP2K20.48654742
60WNK10.47115910
61ATR0.46836203
62CAMK2B0.45984207
63VRK10.44973026
64PRKCQ0.43871601
65PRKCE0.43426350
66JAK30.41829479
67RPS6KA60.41301970
68MET0.39726458
69BUB10.39609165
70KDR0.37633467
71PRKCD0.36196486
72PRKACG0.36184143
73PAK10.35771887
74CSNK2A20.35752104
75BCKDK0.34153309
76PRKCA0.33687702
77SIK10.33468732
78ATM0.33279501
79DYRK30.33165857
80MAPK140.33038109
81STK38L0.32687083
82EGFR0.32275862
83AURKA0.32208208
84PDK10.31697863
85OBSCN0.29709007
86NUAK10.29689461
87MAPK150.29427571
88PRKCB0.29168973
89CSNK1E0.29083137
90SGK4940.28349898
91SGK2230.28349898
92RPS6KA10.28109505
93ROCK10.26884688
94CAMK2A0.26863385
95MKNK10.26416520
96UHMK10.26297692
97ABL10.25289003
98CAMK2D0.25202581
99CDK10.25151252
100PDPK10.24583989

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.31399491
2Asthma_Homo sapiens_hsa053104.23311512
3Oxidative phosphorylation_Homo sapiens_hsa001903.55478349
4Parkinsons disease_Homo sapiens_hsa050123.36918330
5Autoimmune thyroid disease_Homo sapiens_hsa053202.96239640
6Allograft rejection_Homo sapiens_hsa053302.66141553
7Graft-versus-host disease_Homo sapiens_hsa053322.58333210
8One carbon pool by folate_Homo sapiens_hsa006702.46114380
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.35408135
10Alzheimers disease_Homo sapiens_hsa050102.08850276
11Systemic lupus erythematosus_Homo sapiens_hsa053222.07225602
12Cardiac muscle contraction_Homo sapiens_hsa042602.05348058
13Sulfur relay system_Homo sapiens_hsa041222.04472118
14Type I diabetes mellitus_Homo sapiens_hsa049402.04024225
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01110711
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95639910
17Basal transcription factors_Homo sapiens_hsa030221.93180418
18Huntingtons disease_Homo sapiens_hsa050161.89578544
19Non-homologous end-joining_Homo sapiens_hsa034501.82153378
20DNA replication_Homo sapiens_hsa030301.67188640
21Mismatch repair_Homo sapiens_hsa034301.63526374
22Homologous recombination_Homo sapiens_hsa034401.61638141
23Nucleotide excision repair_Homo sapiens_hsa034201.61629981
24Phototransduction_Homo sapiens_hsa047441.57634097
25Olfactory transduction_Homo sapiens_hsa047401.52245537
26Morphine addiction_Homo sapiens_hsa050321.49319368
27Antigen processing and presentation_Homo sapiens_hsa046121.30855034
28RNA degradation_Homo sapiens_hsa030181.25426318
29Rheumatoid arthritis_Homo sapiens_hsa053231.24353962
30Fanconi anemia pathway_Homo sapiens_hsa034601.22393233
31Base excision repair_Homo sapiens_hsa034101.22060748
32Viral myocarditis_Homo sapiens_hsa054161.21403026
33Nitrogen metabolism_Homo sapiens_hsa009101.18827486
34Alcoholism_Homo sapiens_hsa050341.15421745
35Glutathione metabolism_Homo sapiens_hsa004801.09623160
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07887789
37RNA transport_Homo sapiens_hsa030131.05220341
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04976309
39Arachidonic acid metabolism_Homo sapiens_hsa005900.99624204
40Staphylococcus aureus infection_Homo sapiens_hsa051500.98590029
41Tryptophan metabolism_Homo sapiens_hsa003800.98382680
42Hedgehog signaling pathway_Homo sapiens_hsa043400.94966768
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88422137
44Thyroid hormone synthesis_Homo sapiens_hsa049180.86166496
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83995666
46Selenocompound metabolism_Homo sapiens_hsa004500.79573377
47Circadian rhythm_Homo sapiens_hsa047100.77230152
48Basal cell carcinoma_Homo sapiens_hsa052170.75777422
49Cell cycle_Homo sapiens_hsa041100.73958724
50RNA polymerase_Homo sapiens_hsa030200.73884407
51Linoleic acid metabolism_Homo sapiens_hsa005910.72759302
52Salivary secretion_Homo sapiens_hsa049700.72561502
53Protein export_Homo sapiens_hsa030600.71808130
54GABAergic synapse_Homo sapiens_hsa047270.66481938
55Taste transduction_Homo sapiens_hsa047420.66200891
56Circadian entrainment_Homo sapiens_hsa047130.64796378
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64211109
58Nicotine addiction_Homo sapiens_hsa050330.62108816
59Collecting duct acid secretion_Homo sapiens_hsa049660.60586823
60Proteasome_Homo sapiens_hsa030500.60523703
61African trypanosomiasis_Homo sapiens_hsa051430.57995834
62Purine metabolism_Homo sapiens_hsa002300.56731377
63TGF-beta signaling pathway_Homo sapiens_hsa043500.56346475
64Pyrimidine metabolism_Homo sapiens_hsa002400.52759451
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49626484
66Chemical carcinogenesis_Homo sapiens_hsa052040.48888324
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45614199
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45346125
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45335521
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44646764
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43370679
72Retinol metabolism_Homo sapiens_hsa008300.42261707
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42047034
74Serotonergic synapse_Homo sapiens_hsa047260.37531517
75Spliceosome_Homo sapiens_hsa030400.36947729
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34946219
77Phenylalanine metabolism_Homo sapiens_hsa003600.34791035
78Legionellosis_Homo sapiens_hsa051340.32093450
79Insulin secretion_Homo sapiens_hsa049110.31173217
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30492169
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.30028743
82Cocaine addiction_Homo sapiens_hsa050300.29353809
83Ovarian steroidogenesis_Homo sapiens_hsa049130.29317421
84Tuberculosis_Homo sapiens_hsa051520.28790720
85Ether lipid metabolism_Homo sapiens_hsa005650.28706425
86Glutamatergic synapse_Homo sapiens_hsa047240.28171749
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27591592
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27152728
89Synaptic vesicle cycle_Homo sapiens_hsa047210.26941605
90Hematopoietic cell lineage_Homo sapiens_hsa046400.25449497
91Leishmaniasis_Homo sapiens_hsa051400.25128009
92Caffeine metabolism_Homo sapiens_hsa002320.23904218
93Arginine biosynthesis_Homo sapiens_hsa002200.23234479
94Fatty acid biosynthesis_Homo sapiens_hsa000610.21358141
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.20386471
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20082657
97Gastric acid secretion_Homo sapiens_hsa049710.19081297
98Cholinergic synapse_Homo sapiens_hsa047250.16044300
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.15122292
100Metabolic pathways_Homo sapiens_hsa011000.14803904

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