ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.92806117
2	viral transcription (GO:0019083)	5.24831941
3	translational termination (GO:0006415)	5.00864814
4	ribosomal small subunit assembly (GO:0000028)	4.80838467
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.41561139
6	ATP synthesis coupled proton transport (GO:0015986)	4.41561139
7	protein neddylation (GO:0045116)	4.25296141
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.09112904
9	translational elongation (GO:0006414)	4.07385123
10	cotranslational protein targeting to membrane (GO:0006613)	4.06508711
11	protein targeting to ER (GO:0045047)	4.02179771
12	somite development (GO:0061053)	3.98241129
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.95238676
14	ribosomal small subunit biogenesis (GO:0042274)	3.95000430
15	chaperone-mediated protein transport (GO:0072321)	3.90199737
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.86784403
17	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.82633263
18	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.76523083
19	cellular protein complex disassembly (GO:0043624)	3.73797093
20	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.72291033
21	protein localization to endoplasmic reticulum (GO:0070972)	3.72184953
22	maturation of SSU-rRNA (GO:0030490)	3.63685154
23	cell proliferation in forebrain (GO:0021846)	3.62229952
24	viral life cycle (GO:0019058)	3.57755914
25	pyrimidine nucleobase catabolic process (GO:0006208)	3.57699252
26	male meiosis I (GO:0007141)	3.44162139
27	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.42007067
28	valine metabolic process (GO:0006573)	3.37600547
29	regulation of feeding behavior (GO:0060259)	3.28120200
30	GTP biosynthetic process (GO:0006183)	3.28025239
31	behavioral response to ethanol (GO:0048149)	3.24787120
32	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	3.24518582
33	protein complex disassembly (GO:0043241)	3.19642739
34	regulation of cilium movement (GO:0003352)	3.16695312
35	forebrain neuron differentiation (GO:0021879)	3.11918727
36	translational initiation (GO:0006413)	3.10574432
37	regulation of isotype switching to IgG isotypes (GO:0048302)	3.05128516
38	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.04206394
39	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.03950256
40	short-term memory (GO:0007614)	3.03006691
41	synapsis (GO:0007129)	3.02769755
42	nucleotide transmembrane transport (GO:1901679)	3.01258316
43	water-soluble vitamin biosynthetic process (GO:0042364)	3.00971622
44	macromolecular complex disassembly (GO:0032984)	3.00682484
45	parturition (GO:0007567)	3.00379665
46	olfactory bulb development (GO:0021772)	3.00199080
47	nonmotile primary cilium assembly (GO:0035058)	2.97201965
48	establishment of mitochondrion localization (GO:0051654)	2.95039606
49	membrane repolarization during action potential (GO:0086011)	2.93017381
50	regulation of penile erection (GO:0060405)	2.90572572
51	mitochondrion transport along microtubule (GO:0047497)	2.89461991
52	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.89461991
53	epithelial cilium movement (GO:0003351)	2.88908305
54	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.88372873
55	dendritic spine morphogenesis (GO:0060997)	2.87523342
56	cerebral cortex radially oriented cell migration (GO:0021799)	2.83775959
57	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.83053765
58	substrate-independent telencephalic tangential migration (GO:0021826)	2.83053765
59	nucleobase catabolic process (GO:0046113)	2.82515171
60	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.81197372
61	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.80526279
62	membrane repolarization (GO:0086009)	2.79112680
63	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.77991739
64	protein polyglutamylation (GO:0018095)	2.76478460
65	cellular anion homeostasis (GO:0030002)	2.72291142
66	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.72110631
67	indolalkylamine metabolic process (GO:0006586)	2.71402403
68	regulation of microtubule-based movement (GO:0060632)	2.71341375
69	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.70844770
70	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.70844770
71	NADH dehydrogenase complex assembly (GO:0010257)	2.70844770
72	negative regulation of multicellular organism growth (GO:0040015)	2.70209488
73	kynurenine metabolic process (GO:0070189)	2.67345800
74	UTP biosynthetic process (GO:0006228)	2.66699778
75	ATP biosynthetic process (GO:0006754)	2.66409625
76	protein complex biogenesis (GO:0070271)	2.66203294
77	negative regulation of mast cell activation (GO:0033004)	2.64101367
78	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.60712713
79	protein K6-linked ubiquitination (GO:0085020)	2.57101420
80	cell migration in hindbrain (GO:0021535)	2.56715433
81	protein targeting to membrane (GO:0006612)	2.56601400
82	negative regulation of appetite (GO:0032099)	2.55975378
83	negative regulation of response to food (GO:0032096)	2.55975378
84	spinal cord development (GO:0021510)	2.55143508
85	synaptic transmission, cholinergic (GO:0007271)	2.54838235
86	endoderm formation (GO:0001706)	2.54247683
87	transmission of nerve impulse (GO:0019226)	2.53677999
88	detection of light stimulus involved in visual perception (GO:0050908)	2.52214166
89	detection of light stimulus involved in sensory perception (GO:0050962)	2.52214166
90	regulation of membrane repolarization (GO:0060306)	2.51462849
91	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.51040034
92	neuronal action potential (GO:0019228)	2.49931696
93	UTP metabolic process (GO:0046051)	2.49842995
94	establishment of nucleus localization (GO:0040023)	2.49550072
95	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.49373280
96	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.48963657
97	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.48963657
98	tryptophan catabolic process (GO:0006569)	2.48796825
99	indole-containing compound catabolic process (GO:0042436)	2.48796825
100	indolalkylamine catabolic process (GO:0046218)	2.48796825

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.07684972
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.49979281
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.94306854
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.75003281
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.72852675
6	VDR_22108803_ChIP-Seq_LS180_Human	2.63179347
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.58343984
8	IRF1_19129219_ChIP-ChIP_H3396_Human	2.53182850
9	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.39976028
10	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.29802453
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.14302006
12	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.05936989
13	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.04833387
14	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.98834631
15	REST_21632747_ChIP-Seq_MESCs_Mouse	1.95191170
16	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.94581917
17	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.92933900
18	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.92794447
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.90820283
20	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.87563728
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.81031022
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.79134794
23	RNF2_27304074_Chip-Seq_NSC_Mouse	1.77628368
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.77071364
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.76794072
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73306751
27	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.66939053
28	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.59569098
29	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.58764525
30	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.58119103
31	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.54494073
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.54348720
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51742491
34	EWS_26573619_Chip-Seq_HEK293_Human	1.49684421
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.48474422
36	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.47502081
37	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.44286883
38	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.44286883
39	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.43173099
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.40794369
41	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.38656239
42	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.36501934
43	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.34796471
44	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.32698679
45	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.32256187
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30338869
47	P300_19829295_ChIP-Seq_ESCs_Human	1.29006786
48	GBX2_23144817_ChIP-Seq_PC3_Human	1.29000446
49	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.28900286
50	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.28482213
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25567015
52	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.25089612
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.24467987
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.24467987
55	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.23822515
56	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.23310914
57	FUS_26573619_Chip-Seq_HEK293_Human	1.22782442
58	TAF15_26573619_Chip-Seq_HEK293_Human	1.22758486
59	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.22619995
60	ERA_21632823_ChIP-Seq_H3396_Human	1.21011520
61	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.17379617
62	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.15806238
63	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.14225494
64	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14029053
65	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12017354
66	ER_23166858_ChIP-Seq_MCF-7_Human	1.10835872
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10579485
68	AR_21572438_ChIP-Seq_LNCaP_Human	1.08578328
69	TAF2_19829295_ChIP-Seq_ESCs_Human	1.07609342
70	IGF1R_20145208_ChIP-Seq_DFB_Human	1.07379683
71	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.07285284
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.06942878
73	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.06141793
74	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.03071631
75	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.02037851
76	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.01739895
77	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01604723
78	NCOR_22424771_ChIP-Seq_293T_Human	1.00859250
79	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.00066731
80	TP53_22573176_ChIP-Seq_HFKS_Human	0.99547687
81	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.98347126
82	NANOG_20526341_ChIP-Seq_ESCs_Human	0.98292650
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97478495
84	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.97245777
85	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.96857632
86	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.94450136
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93433770
88	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.93293113
89	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.91392699
90	RUNX2_22187159_ChIP-Seq_PCA_Human	0.91277066
91	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.90613509
92	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.90040383
93	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.90040383
94	TCF4_22108803_ChIP-Seq_LS180_Human	0.89449406
95	TCF4_23295773_ChIP-Seq_U87_Human	0.89152905
96	SMAD4_21799915_ChIP-Seq_A2780_Human	0.88310989
97	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88011552
98	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.87854881
99	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.87794880
100	AR_25329375_ChIP-Seq_VCAP_Human	0.87588405

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.55081002
2	MP0006292_abnormal_olfactory_placode	4.24063574
3	MP0002653_abnormal_ependyma_morphology	3.34557663
4	MP0003787_abnormal_imprinting	2.57014276
5	MP0006276_abnormal_autonomic_nervous	2.48731061
6	MP0003122_maternal_imprinting	2.42764851
7	MP0008877_abnormal_DNA_methylation	2.33400893
8	MP0003011_delayed_dark_adaptation	2.27010903
9	MP0001188_hyperpigmentation	2.25409871
10	MP0008789_abnormal_olfactory_epithelium	2.22114989
11	MP0003646_muscle_fatigue	2.21932027
12	MP0005394_taste/olfaction_phenotype	2.17925804
13	MP0005499_abnormal_olfactory_system	2.17925804
14	MP0004885_abnormal_endolymph	2.10596135
15	MP0003121_genomic_imprinting	2.07906200
16	MP0003880_abnormal_central_pattern	1.98824511
17	MP0000778_abnormal_nervous_system	1.90478814
18	MP0005551_abnormal_eye_electrophysiolog	1.85129858
19	MP0001485_abnormal_pinna_reflex	1.77630872
20	MP0003878_abnormal_ear_physiology	1.70885369
21	MP0005377_hearing/vestibular/ear_phenot	1.70885369
22	MP0001984_abnormal_olfaction	1.66882767
23	MP0001968_abnormal_touch/_nociception	1.65514346
24	MP0003136_yellow_coat_color	1.64080049
25	MP0002102_abnormal_ear_morphology	1.63361184
26	MP0001293_anophthalmia	1.63038506
27	MP0004142_abnormal_muscle_tone	1.62204264
28	MP0002736_abnormal_nociception_after	1.59928916
29	MP0002938_white_spotting	1.58422764
30	MP0003123_paternal_imprinting	1.58112869
31	MP0002837_dystrophic_cardiac_calcinosis	1.57143679
32	MP0005423_abnormal_somatic_nervous	1.51782067
33	MP0002272_abnormal_nervous_system	1.51320835
34	MP0000631_abnormal_neuroendocrine_gland	1.50454572
35	MP0000566_synostosis	1.50066817
36	MP0002638_abnormal_pupillary_reflex	1.49779388
37	MP0008872_abnormal_physiological_respon	1.49041461
38	MP0008875_abnormal_xenobiotic_pharmacok	1.46983471
39	MP0002160_abnormal_reproductive_system	1.45463075
40	MP0002822_catalepsy	1.39576863
41	MP0009745_abnormal_behavioral_response	1.39545412
42	MP0000049_abnormal_middle_ear	1.35808148
43	MP0001440_abnormal_grooming_behavior	1.35479187
44	MP0004742_abnormal_vestibular_system	1.34806492
45	MP0001529_abnormal_vocalization	1.27162828
46	MP0002184_abnormal_innervation	1.27082138
47	MP0005389_reproductive_system_phenotype	1.26637916
48	MP0002557_abnormal_social/conspecific_i	1.26456313
49	MP0002234_abnormal_pharynx_morphology	1.26251088
50	MP0004145_abnormal_muscle_electrophysio	1.24519947
51	MP0005195_abnormal_posterior_eye	1.22882837
52	MP0002928_abnormal_bile_duct	1.22428529
53	MP0001905_abnormal_dopamine_level	1.20565494
54	MP0002063_abnormal_learning/memory/cond	1.19755303
55	MP0005084_abnormal_gallbladder_morpholo	1.19661244
56	MP0006072_abnormal_retinal_apoptosis	1.19500170
57	MP0002752_abnormal_somatic_nervous	1.18176415
58	MP0004133_heterotaxia	1.17825590
59	MP0009046_muscle_twitch	1.17810618
60	MP0002572_abnormal_emotion/affect_behav	1.16315429
61	MP0004782_abnormal_surfactant_physiolog	1.14843021
62	MP0002163_abnormal_gland_morphology	1.14688062
63	MP0003879_abnormal_hair_cell	1.12853747
64	MP0008058_abnormal_DNA_repair	1.08836492
65	MP0003890_abnormal_embryonic-extraembry	1.08612967
66	MP0003635_abnormal_synaptic_transmissio	1.08485222
67	MP0000955_abnormal_spinal_cord	1.08009380
68	MP0001986_abnormal_taste_sensitivity	1.07789182
69	MP0001486_abnormal_startle_reflex	1.07683918
70	MP0005645_abnormal_hypothalamus_physiol	1.06789075
71	MP0000026_abnormal_inner_ear	1.05798213
72	MP0005646_abnormal_pituitary_gland	1.04358454
73	MP0010030_abnormal_orbit_morphology	1.03425653
74	MP0001970_abnormal_pain_threshold	1.02769554
75	MP0001502_abnormal_circadian_rhythm	1.01937510
76	MP0002233_abnormal_nose_morphology	0.98190879
77	MP0005253_abnormal_eye_physiology	0.97316845
78	MP0002734_abnormal_mechanical_nocicepti	0.97183627
79	MP0003938_abnormal_ear_development	0.95725756
80	MP0002733_abnormal_thermal_nociception	0.94033953
81	MP0002735_abnormal_chemical_nociception	0.93780677
82	MP0002882_abnormal_neuron_morphology	0.93184717
83	MP0000534_abnormal_ureter_morphology	0.92725434
84	MP0001963_abnormal_hearing_physiology	0.91825676
85	MP0002876_abnormal_thyroid_physiology	0.90318861
86	MP0002064_seizures	0.89950323
87	MP0005410_abnormal_fertilization	0.89085235
88	MP0001919_abnormal_reproductive_system	0.87537984
89	MP0002210_abnormal_sex_determination	0.87440380
90	MP0003195_calcinosis	0.85968460
91	MP0004924_abnormal_behavior	0.84457742
92	MP0005386_behavior/neurological_phenoty	0.84457742
93	MP0004859_abnormal_synaptic_plasticity	0.83984692
94	MP0003942_abnormal_urinary_system	0.83823332
95	MP0001286_abnormal_eye_development	0.81847777
96	MP0002152_abnormal_brain_morphology	0.81727287
97	MP0003119_abnormal_digestive_system	0.80829244
98	MP0004085_abnormal_heartbeat	0.78543992
99	MP0002138_abnormal_hepatobiliary_system	0.76484606
100	MP0004043_abnormal_pH_regulation	0.74704381

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.32414338
2	Pancreatic fibrosis (HP:0100732)	4.00951390
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.81835003
4	Absent/shortened dynein arms (HP:0200106)	3.81835003
5	Abnormality of midbrain morphology (HP:0002418)	3.59984940
6	Molar tooth sign on MRI (HP:0002419)	3.59984940
7	Abnormal rod and cone electroretinograms (HP:0008323)	3.40557552
8	Reticulocytopenia (HP:0001896)	3.36593021
9	Nephronophthisis (HP:0000090)	3.08153160
10	Pancreatic cysts (HP:0001737)	3.05889897
11	Abnormality of the labia minora (HP:0012880)	3.01178494
12	Hyperventilation (HP:0002883)	2.93267498
13	True hermaphroditism (HP:0010459)	2.84021665
14	Abnormal respiratory epithelium morphology (HP:0012253)	2.79022668
15	Abnormal respiratory motile cilium morphology (HP:0005938)	2.79022668
16	Cystic liver disease (HP:0006706)	2.74300753
17	Anencephaly (HP:0002323)	2.66365347
18	Pendular nystagmus (HP:0012043)	2.58235355
19	Progressive cerebellar ataxia (HP:0002073)	2.55905259
20	Chronic hepatic failure (HP:0100626)	2.53466898
21	Abnormality of the renal medulla (HP:0100957)	2.52419422
22	Pachygyria (HP:0001302)	2.51181980
23	Abnormal ciliary motility (HP:0012262)	2.45724478
24	Medial flaring of the eyebrow (HP:0010747)	2.44410093
25	Pallor (HP:0000980)	2.41905933
26	Sclerocornea (HP:0000647)	2.41674832
27	Acute necrotizing encephalopathy (HP:0006965)	2.41549631
28	Rib fusion (HP:0000902)	2.40468859
29	Bony spicule pigmentary retinopathy (HP:0007737)	2.39931594
30	Lissencephaly (HP:0001339)	2.39629736
31	Decreased central vision (HP:0007663)	2.36916764
32	Colon cancer (HP:0003003)	2.35467944
33	Congenital stationary night blindness (HP:0007642)	2.35093000
34	Abnormality of cells of the erythroid lineage (HP:0012130)	2.34905308
35	Abnormality of the 4th metacarpal (HP:0010012)	2.31052622
36	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.29726679
37	Short 4th metacarpal (HP:0010044)	2.29726679
38	Macrocytic anemia (HP:0001972)	2.28087327
39	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.25509240
40	Asplenia (HP:0001746)	2.25313556
41	Focal motor seizures (HP:0011153)	2.25251178
42	Stenosis of the external auditory canal (HP:0000402)	2.23347356
43	Epileptic encephalopathy (HP:0200134)	2.18248411
44	Lipid accumulation in hepatocytes (HP:0006561)	2.17445978
45	Acute encephalopathy (HP:0006846)	2.14447054
46	Dyskinesia (HP:0100660)	2.13229574
47	Type II lissencephaly (HP:0007260)	2.12153136
48	Status epilepticus (HP:0002133)	2.10894702
49	Bile duct proliferation (HP:0001408)	2.10421175
50	Abnormal biliary tract physiology (HP:0012439)	2.10421175
51	Increased hepatocellular lipid droplets (HP:0006565)	2.10347877
52	Abnormality of the renal cortex (HP:0011035)	2.09615547
53	Postaxial foot polydactyly (HP:0001830)	2.09536341
54	Mitochondrial inheritance (HP:0001427)	2.08775606
55	Septo-optic dysplasia (HP:0100842)	2.07772115
56	Abnormal respiratory motile cilium physiology (HP:0012261)	2.06958783
57	Myokymia (HP:0002411)	2.06869200
58	Progressive macrocephaly (HP:0004481)	2.06161868
59	Abnormal mitochondria in muscle tissue (HP:0008316)	2.05347109
60	Shawl scrotum (HP:0000049)	2.04077851
61	Anophthalmia (HP:0000528)	2.03224192
62	Focal seizures (HP:0007359)	2.01951170
63	Absent thumb (HP:0009777)	2.01701862
64	Gait imbalance (HP:0002141)	2.00082609
65	Abolished electroretinogram (ERG) (HP:0000550)	1.95668163
66	Genital tract atresia (HP:0001827)	1.95354188
67	Abnormal drinking behavior (HP:0030082)	1.93244203
68	Polydipsia (HP:0001959)	1.93244203
69	3-Methylglutaconic aciduria (HP:0003535)	1.93056725
70	Hyperglycinemia (HP:0002154)	1.92538075
71	Nephrogenic diabetes insipidus (HP:0009806)	1.86957215
72	Aplasia/Hypoplasia of the patella (HP:0006498)	1.84377941
73	Patellar aplasia (HP:0006443)	1.84305416
74	Polyphagia (HP:0002591)	1.84152675
75	Increased CSF lactate (HP:0002490)	1.83722651
76	Vaginal atresia (HP:0000148)	1.82109595
77	Renal cortical cysts (HP:0000803)	1.81560966
78	Congenital primary aphakia (HP:0007707)	1.81187421
79	Limb dystonia (HP:0002451)	1.80824973
80	Decreased circulating renin level (HP:0003351)	1.80693533
81	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.80146055
82	Preaxial hand polydactyly (HP:0001177)	1.79548780
83	Hypoplasia of the ulna (HP:0003022)	1.78177343
84	Renal Fanconi syndrome (HP:0001994)	1.75864331
85	Occipital encephalocele (HP:0002085)	1.75094521
86	Postaxial hand polydactyly (HP:0001162)	1.73583013
87	Abnormal number of erythroid precursors (HP:0012131)	1.73430199
88	Retinal dysplasia (HP:0007973)	1.71509391
89	Abnormality of renal resorption (HP:0011038)	1.70213092
90	Congenital hepatic fibrosis (HP:0002612)	1.70079369
91	Agitation (HP:0000713)	1.69823165
92	Glycosuria (HP:0003076)	1.68423374
93	Abnormality of urine glucose concentration (HP:0011016)	1.68423374
94	Small hand (HP:0200055)	1.66649768
95	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.66193556
96	Hypoplasia of the brainstem (HP:0002365)	1.66193556
97	Optic nerve hypoplasia (HP:0000609)	1.65924907
98	Broad-based gait (HP:0002136)	1.65713605
99	Optic disc pallor (HP:0000543)	1.64940749
100	Triphalangeal thumb (HP:0001199)	1.64615777

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.20115736
2	TLK1	3.18881586
3	WNK4	3.07088455
4	MAP4K2	2.75720624
5	WNK3	2.57155884
6	ZAK	2.41176527
7	TXK	2.40101726
8	BMPR1B	2.33805944
9	STK39	2.19016462
10	CDC7	2.08521282
11	MARK1	1.94851896
12	NUAK1	1.92254954
13	GRK1	1.83833273
14	GRK7	1.82126294
15	DYRK2	1.65385319
16	FGFR2	1.64275726
17	ADRBK2	1.62537760
18	TGFBR2	1.58620919
19	MAPK13	1.54270134
20	PIK3CA	1.53753243
21	PINK1	1.52794189
22	TNIK	1.52668106
23	CAMKK2	1.43422219
24	CASK	1.33720243
25	EPHB2	1.28696585
26	TYRO3	1.28063140
27	INSRR	1.27450336
28	PAK3	1.26009093
29	STK16	1.19211069
30	BCKDK	1.18594008
31	SGK2	1.16767977
32	SGK494	1.16617165
33	SGK223	1.16617165
34	TAOK1	1.16041069
35	CDK19	1.15042435
36	AKT3	1.10948104
37	OXSR1	1.10302363
38	CAMK1	1.09528079
39	NTRK2	1.05662454
40	PRKCG	1.02651529
41	CAMKK1	0.98781960
42	STK11	0.98612080
43	SIK2	0.98013300
44	MAP3K11	0.97071531
45	MINK1	0.94665592
46	DAPK2	0.92793335
47	VRK1	0.92692517
48	ADRBK1	0.91350933
49	MAP2K7	0.90258138
50	PRKCQ	0.88932752
51	TIE1	0.88060130
52	MAPK15	0.86635347
53	VRK2	0.86551318
54	PLK1	0.85798791
55	NEK2	0.84820931
56	EPHA4	0.84501478
57	BRAF	0.81067586
58	PRKACA	0.76483759
59	MAP3K4	0.75505663
60	LATS1	0.72407615
61	CSNK1G2	0.69477842
62	PLK4	0.69126986
63	RPS6KA6	0.67442356
64	NTRK3	0.65554561
65	PRKCZ	0.65054174
66	DYRK3	0.63054649
67	CAMK4	0.62680443
68	PHKG2	0.62363333
69	PHKG1	0.62363333
70	PKN1	0.62258070
71	MKNK2	0.61944826
72	SGK1	0.61528721
73	TAOK3	0.60873170
74	GRK5	0.60098891
75	MUSK	0.59895167
76	CSNK1G3	0.58291869
77	AURKB	0.57163240
78	NEK1	0.55605809
79	CAMK2A	0.54365834
80	RPS6KA2	0.54214051
81	PNCK	0.54028207
82	NME1	0.52907921
83	RPS6KA5	0.51546443
84	AURKA	0.51366054
85	DYRK1A	0.50693148
86	SGK3	0.50318009
87	PAK6	0.48769151
88	ACVR1B	0.46327172
89	RPS6KC1	0.46032065
90	RPS6KL1	0.46032065
91	STK3	0.43282110
92	CSNK1A1	0.42822816
93	PDK2	0.42660970
94	CSNK1A1L	0.41616450
95	PRKCA	0.38944196
96	CAMK1G	0.38909496
97	PLK2	0.38174458
98	OBSCN	0.37942282
99	ATR	0.37723863
100	CSNK1G1	0.36791072

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.79084022
2	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.81977803
3	Sulfur relay system_Homo sapiens_hsa04122	3.03449425
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.92564648
5	Phototransduction_Homo sapiens_hsa04744	2.87509438
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.61152119
7	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.33852270
8	Homologous recombination_Homo sapiens_hsa03440	2.31024548
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.20160853
10	Caffeine metabolism_Homo sapiens_hsa00232	2.16850043
11	Parkinsons disease_Homo sapiens_hsa05012	2.12769204
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.09035817
13	Cardiac muscle contraction_Homo sapiens_hsa04260	2.02981280
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.96147094
15	Ether lipid metabolism_Homo sapiens_hsa00565	1.88878700
16	Protein export_Homo sapiens_hsa03060	1.83322862
17	Nicotine addiction_Homo sapiens_hsa05033	1.78097056
18	Huntingtons disease_Homo sapiens_hsa05016	1.67345014
19	RNA polymerase_Homo sapiens_hsa03020	1.65587182
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.52096646
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.46816527
22	Alzheimers disease_Homo sapiens_hsa05010	1.46519802
23	RNA degradation_Homo sapiens_hsa03018	1.43766906
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.42464577
25	Basal transcription factors_Homo sapiens_hsa03022	1.40025211
26	Folate biosynthesis_Homo sapiens_hsa00790	1.39048789
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.35995309
28	Morphine addiction_Homo sapiens_hsa05032	1.33766722
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25427328
30	Olfactory transduction_Homo sapiens_hsa04740	1.24710780
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.22771952
32	Insulin secretion_Homo sapiens_hsa04911	1.20557853
33	Retinol metabolism_Homo sapiens_hsa00830	1.19047612
34	Peroxisome_Homo sapiens_hsa04146	1.12174825
35	Glutamatergic synapse_Homo sapiens_hsa04724	0.98945143
36	Mismatch repair_Homo sapiens_hsa03430	0.98898033
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98340488
38	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.98245748
39	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.94428519
40	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94424866
41	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.93843981
42	Serotonergic synapse_Homo sapiens_hsa04726	0.90984626
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.90512402
44	Asthma_Homo sapiens_hsa05310	0.88678018
45	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.87852347
46	Circadian entrainment_Homo sapiens_hsa04713	0.87069282
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84863930
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82038387
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.81889413
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.78573253
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78266714
52	Propanoate metabolism_Homo sapiens_hsa00640	0.77078404
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.76862483
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.75323203
55	Cholinergic synapse_Homo sapiens_hsa04725	0.75253753
56	Dopaminergic synapse_Homo sapiens_hsa04728	0.73788419
57	One carbon pool by folate_Homo sapiens_hsa00670	0.73133825
58	Taste transduction_Homo sapiens_hsa04742	0.69772529
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.68548458
60	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.68383284
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.67748009
62	Basal cell carcinoma_Homo sapiens_hsa05217	0.61036446
63	Steroid biosynthesis_Homo sapiens_hsa00100	0.60751138
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.60163653
65	Butanoate metabolism_Homo sapiens_hsa00650	0.58288333
66	Non-homologous end-joining_Homo sapiens_hsa03450	0.56875829
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56274799
68	GABAergic synapse_Homo sapiens_hsa04727	0.55405818
69	Long-term depression_Homo sapiens_hsa04730	0.54447739
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.53539821
71	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.53181788
72	Metabolic pathways_Homo sapiens_hsa01100	0.52410521
73	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.52325603
74	Salivary secretion_Homo sapiens_hsa04970	0.51986791
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51520992
76	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.51471506
77	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.51351793
78	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.48693143
79	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.47615765
80	Purine metabolism_Homo sapiens_hsa00230	0.47274677
81	Proteasome_Homo sapiens_hsa03050	0.47191994
82	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46072469
83	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.45219759
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43026625
85	Axon guidance_Homo sapiens_hsa04360	0.42764907
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42084126
87	Hippo signaling pathway_Homo sapiens_hsa04390	0.39179171
88	Allograft rejection_Homo sapiens_hsa05330	0.38757283
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.36597015
90	Primary immunodeficiency_Homo sapiens_hsa05340	0.36538309
91	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.35963352
92	Gastric acid secretion_Homo sapiens_hsa04971	0.32637744
93	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.32501124
94	Calcium signaling pathway_Homo sapiens_hsa04020	0.31031939
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.30894671
96	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.29981081
97	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.28913806
98	ABC transporters_Homo sapiens_hsa02010	0.28527224
99	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.27595619
100	Base excision repair_Homo sapiens_hsa03410	0.27020807

RPL31P61

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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