ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of SSU-rRNA (GO:0030490)	9.27288425
2	viral transcription (GO:0019083)	8.83559939
3	translational termination (GO:0006415)	8.45675646
4	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.21466432
5	ribosomal small subunit biogenesis (GO:0042274)	7.19865173
6	cotranslational protein targeting to membrane (GO:0006613)	7.08215847
7	translational elongation (GO:0006414)	7.06170745
8	protein targeting to ER (GO:0045047)	7.02876090
9	ribosomal small subunit assembly (GO:0000028)	6.78328481
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.70250936
11	protein localization to endoplasmic reticulum (GO:0070972)	6.61971993
12	cellular protein complex disassembly (GO:0043624)	6.44287539
13	viral life cycle (GO:0019058)	6.33976205
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.04674770
15	ribosomal large subunit biogenesis (GO:0042273)	5.61276758
16	ATP synthesis coupled proton transport (GO:0015986)	5.41580653
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.41580653
18	protein complex disassembly (GO:0043241)	5.37040479
19	translational initiation (GO:0006413)	5.33226457
20	ovulation cycle (GO:0042698)	5.07072134
21	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	5.05708995
22	macromolecular complex disassembly (GO:0032984)	5.05037325
23	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.99522533
24	behavioral response to nicotine (GO:0035095)	4.70216842
25	protein targeting to membrane (GO:0006612)	4.65849895
26	tyrosine phosphorylation of STAT protein (GO:0007260)	4.58791289
27	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	4.58405417
28	DNA deamination (GO:0045006)	4.52769644
29	translation (GO:0006412)	4.34482140
30	regulation of female gonad development (GO:2000194)	4.33918625
31	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.33538710
32	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.21494407
33	cellular anion homeostasis (GO:0030002)	4.21298388
34	negative regulation of mast cell activation (GO:0033004)	4.19870651
35	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.12014130
36	mRNA catabolic process (GO:0006402)	3.86231420
37	antigen processing and presentation of endogenous antigen (GO:0019883)	3.76543734
38	ribonucleoprotein complex biogenesis (GO:0022613)	3.75407935
39	protein complex biogenesis (GO:0070271)	3.68860545
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.67185280
41	NADH dehydrogenase complex assembly (GO:0010257)	3.67185280
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.67185280
43	chaperone-mediated protein transport (GO:0072321)	3.61974858
44	respiratory electron transport chain (GO:0022904)	3.56238415
45	electron transport chain (GO:0022900)	3.53675935
46	cellular component biogenesis (GO:0044085)	3.49569402
47	regulation of transmission of nerve impulse (GO:0051969)	3.49462818
48	sequestering of actin monomers (GO:0042989)	3.47159544
49	RNA catabolic process (GO:0006401)	3.40285340
50	regulation of bile acid biosynthetic process (GO:0070857)	3.33771458
51	response to pheromone (GO:0019236)	3.30303937
52	regulation of cellular respiration (GO:0043457)	3.24931004
53	intra-S DNA damage checkpoint (GO:0031573)	3.24680293
54	cytidine deamination (GO:0009972)	3.21228780
55	cytidine metabolic process (GO:0046087)	3.21228780
56	cytidine catabolic process (GO:0006216)	3.21228780
57	negative regulation of glycogen biosynthetic process (GO:0045719)	3.19756204
58	mitochondrial respiratory chain complex assembly (GO:0033108)	3.18374426
59	ATP biosynthetic process (GO:0006754)	3.16798816
60	dopamine transport (GO:0015872)	3.09814220
61	establishment of protein localization to membrane (GO:0090150)	3.08373184
62	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.08209044
63	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.06296472
64	protein neddylation (GO:0045116)	3.02773877
65	water-soluble vitamin biosynthetic process (GO:0042364)	2.94907954
66	cell proliferation in forebrain (GO:0021846)	2.94377304
67	cytochrome complex assembly (GO:0017004)	2.94100230
68	protein targeting (GO:0006605)	2.93320972
69	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.92763299
70	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.92763299
71	regulation of mesoderm development (GO:2000380)	2.91847799
72	positive regulation of fatty acid transport (GO:2000193)	2.87869509
73	respiratory chain complex IV assembly (GO:0008535)	2.87020454
74	positive regulation of interleukin-17 production (GO:0032740)	2.85552075
75	cellular biogenic amine catabolic process (GO:0042402)	2.82438995
76	amine catabolic process (GO:0009310)	2.82438995
77	GTP biosynthetic process (GO:0006183)	2.81008098
78	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.80933430
79	positive regulation of icosanoid secretion (GO:0032305)	2.80460648
80	positive regulation of T cell apoptotic process (GO:0070234)	2.80198506
81	negative regulation of glycogen metabolic process (GO:0070874)	2.73321535
82	hydrogen ion transmembrane transport (GO:1902600)	2.73110487
83	establishment of protein localization to organelle (GO:0072594)	2.69202457
84	transmission of nerve impulse (GO:0019226)	2.66855449
85	DNA replication checkpoint (GO:0000076)	2.66249712
86	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.64397203
87	positive regulation of cell fate commitment (GO:0010455)	2.63189212
88	negative regulation of cardiac muscle hypertrophy (GO:0010614)	2.61258562
89	spliceosomal complex assembly (GO:0000245)	2.58300620
90	proton transport (GO:0015992)	2.57039349
91	negative regulation of multicellular organism growth (GO:0040015)	2.56131582
92	aldehyde catabolic process (GO:0046185)	2.55893307
93	negative regulation of potassium ion transport (GO:0043267)	2.53482432
94	tolerance induction (GO:0002507)	2.53325537
95	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.53170086
96	hydrogen transport (GO:0006818)	2.52083985
97	base-excision repair, AP site formation (GO:0006285)	2.49197087
98	termination of RNA polymerase III transcription (GO:0006386)	2.48901223
99	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.48901223
100	heart trabecula morphogenesis (GO:0061384)	2.47569423

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.44008165
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.02470605
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.75184983
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.15105749
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.94586759
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.73993083
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.48314675
8	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.36603245
9	VDR_22108803_ChIP-Seq_LS180_Human	2.20671187
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.19265520
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.11664720
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.09871338
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.07448170
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.00398755
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.00100809
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.97356924
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.87856850
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.84458672
19	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.82841759
20	TP53_22573176_ChIP-Seq_HFKS_Human	1.80870863
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.74451120
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.73326403
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.67694185
24	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.65964259
25	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.64680267
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.58036553
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.57177773
28	TAF2_19829295_ChIP-Seq_ESCs_Human	1.56443762
29	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.52627307
30	VDR_23849224_ChIP-Seq_CD4+_Human	1.48565079
31	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.48428951
32	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.48162568
33	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.47114528
34	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.44949596
35	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.42976132
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.38592567
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.37547075
38	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.36844395
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.36635643
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.35937677
41	XRN2_22483619_ChIP-Seq_HELA_Human	1.35251022
42	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.33994357
43	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.33821954
44	TTF2_22483619_ChIP-Seq_HELA_Human	1.32615768
45	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.29250157
46	ERA_21632823_ChIP-Seq_H3396_Human	1.28394045
47	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.27318265
48	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.26136820
49	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.24041050
50	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.22889849
51	AR_20517297_ChIP-Seq_VCAP_Human	1.21961764
52	NANOG_20526341_ChIP-Seq_ESCs_Human	1.20868160
53	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20293839
54	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.19678049
55	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.18871794
56	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.18413508
57	NCOR_22424771_ChIP-Seq_293T_Human	1.18196222
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17900888
59	P53_21459846_ChIP-Seq_SAOS-2_Human	1.17581505
60	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.17265139
61	MYC_19829295_ChIP-Seq_ESCs_Human	1.16928835
62	E2F1_20622854_ChIP-Seq_HELA_Human	1.16003590
63	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.14566228
64	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.14430896
65	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.13557753
66	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.13530711
67	CTCF_20526341_ChIP-Seq_ESCs_Human	1.12725070
68	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.12708824
69	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.12573557
70	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.12497487
71	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.11780034
72	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11070344
73	IGF1R_20145208_ChIP-Seq_DFB_Human	1.10731309
74	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.10708063
75	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.09944776
76	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.07157516
77	BCL6_27268052_Chip-Seq_Bcells_Human	1.07142559
78	STAT1_20625510_ChIP-Seq_HELA_Human	1.06952442
79	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.05678771
80	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.05196113
81	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04652526
82	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04206535
83	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03822343
84	EWS_26573619_Chip-Seq_HEK293_Human	1.03165713
85	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.02683510
86	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.01715142
87	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.00577448
88	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.00393335
89	REST_21632747_ChIP-Seq_MESCs_Mouse	0.99812364
90	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98983916
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98343728
92	ERG_20517297_ChIP-Seq_VCAP_Human	0.96184874
93	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.96056109
94	P300_27268052_Chip-Seq_Bcells_Human	0.95449735
95	ER_23166858_ChIP-Seq_MCF-7_Human	0.94995114
96	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.93625455
97	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.93625455
98	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.92577567
99	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.91776658
100	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.91222170

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.05935678
2	MP0005646_abnormal_pituitary_gland	3.78161255
3	MP0003315_abnormal_perineum_morphology	3.59756764
4	MP0006292_abnormal_olfactory_placode	3.59463432
5	MP0002234_abnormal_pharynx_morphology	2.99719732
6	MP0002837_dystrophic_cardiac_calcinosis	2.92008080
7	MP0002653_abnormal_ependyma_morphology	2.88499192
8	MP0001835_abnormal_antigen_presentation	2.65380052
9	MP0005187_abnormal_penis_morphology	2.59334902
10	MP0001529_abnormal_vocalization	2.35531432
11	MP0006054_spinal_hemorrhage	2.27685267
12	MP0004145_abnormal_muscle_electrophysio	2.25414678
13	MP0003195_calcinosis	2.24825818
14	MP0005645_abnormal_hypothalamus_physiol	2.11347869
15	MP0002163_abnormal_gland_morphology	2.06056031
16	MP0001986_abnormal_taste_sensitivity	2.05193201
17	MP0003646_muscle_fatigue	2.01414113
18	MP0002138_abnormal_hepatobiliary_system	2.00902036
19	MP0000613_abnormal_salivary_gland	1.97726623
20	MP0005671_abnormal_response_to	1.89228655
21	MP0001873_stomach_inflammation	1.79388803
22	MP0003806_abnormal_nucleotide_metabolis	1.69578068
23	MP0000372_irregular_coat_pigmentation	1.62229656
24	MP0002160_abnormal_reproductive_system	1.55461261
25	MP0008875_abnormal_xenobiotic_pharmacok	1.53251006
26	MP0003136_yellow_coat_color	1.52724591
27	MP0001348_abnormal_lacrimal_gland	1.52712796
28	MP0008789_abnormal_olfactory_epithelium	1.48315009
29	MP0004142_abnormal_muscle_tone	1.47716270
30	MP0002938_white_spotting	1.40676314
31	MP0006072_abnormal_retinal_apoptosis	1.40410127
32	MP0005389_reproductive_system_phenotype	1.37945407
33	MP0008872_abnormal_physiological_respon	1.36241200
34	MP0003880_abnormal_central_pattern	1.32395619
35	MP0003878_abnormal_ear_physiology	1.30807475
36	MP0005377_hearing/vestibular/ear_phenot	1.30807475
37	MP0002272_abnormal_nervous_system	1.30647209
38	MP0009046_muscle_twitch	1.28247492
39	MP0004130_abnormal_muscle_cell	1.27520369
40	MP0001968_abnormal_touch/_nociception	1.25475583
41	MP0000049_abnormal_middle_ear	1.19685677
42	MP0002736_abnormal_nociception_after	1.19526255
43	MP0001984_abnormal_olfaction	1.18062546
44	MP0004147_increased_porphyrin_level	1.17813538
45	MP0003122_maternal_imprinting	1.15395356
46	MP0002277_abnormal_respiratory_mucosa	1.14978664
47	MP0003186_abnormal_redox_activity	1.13877467
48	MP0002102_abnormal_ear_morphology	1.13774211
49	MP0005360_urolithiasis	1.12509483
50	MP0005551_abnormal_eye_electrophysiolog	1.12348983
51	MP0006276_abnormal_autonomic_nervous	1.12098611
52	MP0003879_abnormal_hair_cell	1.12018097
53	MP0009745_abnormal_behavioral_response	1.11514639
54	MP0001919_abnormal_reproductive_system	1.11452561
55	MP0001485_abnormal_pinna_reflex	1.10223905
56	MP0005499_abnormal_olfactory_system	1.08446958
57	MP0005394_taste/olfaction_phenotype	1.08446958
58	MP0001905_abnormal_dopamine_level	1.03569192
59	MP0002733_abnormal_thermal_nociception	1.01238165
60	MP0005379_endocrine/exocrine_gland_phen	0.99657724
61	MP0004885_abnormal_endolymph	0.95781224
62	MP0001970_abnormal_pain_threshold	0.93274279
63	MP0001800_abnormal_humoral_immune	0.93144499
64	MP0001663_abnormal_digestive_system	0.89888163
65	MP0003567_abnormal_fetal_cardiomyocyte	0.87982083
66	MP0002557_abnormal_social/conspecific_i	0.85849182
67	MP0003787_abnormal_imprinting	0.83051369
68	MP0005423_abnormal_somatic_nervous	0.82069332
69	MP0008877_abnormal_DNA_methylation	0.81815503
70	MP0003936_abnormal_reproductive_system	0.81698537
71	MP0003252_abnormal_bile_duct	0.80862206
72	MP0005332_abnormal_amino_acid	0.78836538
73	MP0002638_abnormal_pupillary_reflex	0.77907234
74	MP0003011_delayed_dark_adaptation	0.76307876
75	MP0000026_abnormal_inner_ear	0.75490784
76	MP0001440_abnormal_grooming_behavior	0.75111192
77	MP0009785_altered_susceptibility_to	0.74555232
78	MP0002693_abnormal_pancreas_physiology	0.74388329
79	MP0003123_paternal_imprinting	0.72254574
80	MP0004133_heterotaxia	0.71313516
81	MP0005195_abnormal_posterior_eye	0.69306097
82	MP0004742_abnormal_vestibular_system	0.69218186
83	MP0002876_abnormal_thyroid_physiology	0.68873396
84	MP0008775_abnormal_heart_ventricle	0.68687914
85	MP0005410_abnormal_fertilization	0.68071822
86	MP0000631_abnormal_neuroendocrine_gland	0.66352758
87	MP0000678_abnormal_parathyroid_gland	0.66283582
88	MP0002095_abnormal_skin_pigmentation	0.65881270
89	MP0009250_abnormal_appendicular_skeleto	0.65311518
90	MP0002735_abnormal_chemical_nociception	0.63886720
91	MP0002210_abnormal_sex_determination	0.63576646
92	MP0005623_abnormal_meninges_morphology	0.63016599
93	MP0002928_abnormal_bile_duct	0.62845216
94	MP0005253_abnormal_eye_physiology	0.62238199
95	MP0002734_abnormal_mechanical_nocicepti	0.61612461
96	MP0001963_abnormal_hearing_physiology	0.61609111
97	MP0001119_abnormal_female_reproductive	0.60925110
98	MP0005636_abnormal_mineral_homeostasis	0.60797030
99	MP0000685_abnormal_immune_system	0.60612265
100	MP0001790_abnormal_immune_system	0.59724833

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic otitis media (HP:0000389)	6.42918066
2	Chronic sinusitis (HP:0011109)	4.90931078
3	Nasal polyposis (HP:0100582)	4.73590157
4	Acute necrotizing encephalopathy (HP:0006965)	4.31095417
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.98829754
6	Abnormality of cells of the erythroid lineage (HP:0012130)	3.96396549
7	3-Methylglutaconic aciduria (HP:0003535)	3.93196594
8	Abnormality of the nasal mucosa (HP:0000433)	3.81953364
9	Reticulocytopenia (HP:0001896)	3.81214680
10	Mitochondrial inheritance (HP:0001427)	3.75904878
11	Macrocytic anemia (HP:0001972)	3.74182576
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.54954667
13	Progressive macrocephaly (HP:0004481)	3.50718480
14	Increased IgM level (HP:0003496)	3.49666155
15	Acute encephalopathy (HP:0006846)	3.49103938
16	Autoimmune thrombocytopenia (HP:0001973)	3.41116345
17	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.40493308
18	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.40493308
19	Chronic hepatic failure (HP:0100626)	3.32391993
20	Abnormal number of erythroid precursors (HP:0012131)	3.29712707
21	Hypothermia (HP:0002045)	3.26072468
22	Increased CSF lactate (HP:0002490)	3.22860952
23	Abnormal rod and cone electroretinograms (HP:0008323)	3.22622820
24	Congenital stationary night blindness (HP:0007642)	3.20707664
25	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.12802728
26	Absent/shortened dynein arms (HP:0200106)	3.12802728
27	Hepatocellular necrosis (HP:0001404)	3.05065052
28	Enlarged epiphyses (HP:0010580)	3.01497032
29	Pallor (HP:0000980)	2.98532735
30	Recurrent bronchitis (HP:0002837)	2.83137351
31	Congenital, generalized hypertrichosis (HP:0004540)	2.80625208
32	Molar tooth sign on MRI (HP:0002419)	2.75930953
33	Abnormality of midbrain morphology (HP:0002418)	2.75930953
34	Autoimmune hemolytic anemia (HP:0001890)	2.69094010
35	Abnormal respiratory epithelium morphology (HP:0012253)	2.62985906
36	Abnormal respiratory motile cilium morphology (HP:0005938)	2.62985906
37	Bony spicule pigmentary retinopathy (HP:0007737)	2.62324630
38	Abnormal ciliary motility (HP:0012262)	2.61734729
39	Hepatic necrosis (HP:0002605)	2.54289062
40	Renal Fanconi syndrome (HP:0001994)	2.52696072
41	Increased hepatocellular lipid droplets (HP:0006565)	2.50999571
42	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.49032535
43	Stenosis of the external auditory canal (HP:0000402)	2.46961015
44	Medial flaring of the eyebrow (HP:0010747)	2.46033923
45	Birth length less than 3rd percentile (HP:0003561)	2.44940883
46	Optic disc pallor (HP:0000543)	2.43859137
47	Cerebral edema (HP:0002181)	2.41426502
48	Agammaglobulinemia (HP:0004432)	2.40839452
49	True hermaphroditism (HP:0010459)	2.37955260
50	Constricted visual fields (HP:0001133)	2.33148458
51	Colon cancer (HP:0003003)	2.32233798
52	Pancreatic cysts (HP:0001737)	2.31880082
53	Elevated erythrocyte sedimentation rate (HP:0003565)	2.28149932
54	Anosmia (HP:0000458)	2.27986054
55	Myotonia (HP:0002486)	2.23323618
56	Pancreatic fibrosis (HP:0100732)	2.21315914
57	Nephronophthisis (HP:0000090)	2.20555738
58	Respiratory failure (HP:0002878)	2.18575010
59	Increased intramyocellular lipid droplets (HP:0012240)	2.14869221
60	Lipid accumulation in hepatocytes (HP:0006561)	2.12492926
61	Increased serum lactate (HP:0002151)	2.11061632
62	Lethargy (HP:0001254)	2.10918704
63	Anterior segment dysgenesis (HP:0007700)	2.07396948
64	Abnormal respiratory motile cilium physiology (HP:0012261)	2.06497391
65	Lactic acidosis (HP:0003128)	2.01399445
66	Absent thumb (HP:0009777)	2.00789145
67	Bronchitis (HP:0012387)	1.99694475
68	Bronchiectasis (HP:0002110)	1.97716367
69	Lip pit (HP:0100267)	1.95811983
70	Abnormality of T cell number (HP:0011839)	1.94948831
71	Septo-optic dysplasia (HP:0100842)	1.93564752
72	Sclerocornea (HP:0000647)	1.92776140
73	Abnormality of renal resorption (HP:0011038)	1.92096229
74	Hypochromic anemia (HP:0001931)	1.91901292
75	Eosinophilia (HP:0001880)	1.91787705
76	Abnormal drinking behavior (HP:0030082)	1.90913951
77	Polydipsia (HP:0001959)	1.90913951
78	Progressive cerebellar ataxia (HP:0002073)	1.87718414
79	Hypogonadotrophic hypogonadism (HP:0000044)	1.86318874
80	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.83703938
81	Agitation (HP:0000713)	1.83269520
82	Abolished electroretinogram (ERG) (HP:0000550)	1.81613214
83	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.81206507
84	Methylmalonic acidemia (HP:0002912)	1.80479055
85	Type 2 muscle fiber atrophy (HP:0003554)	1.78468941
86	Type II lissencephaly (HP:0007260)	1.76897791
87	Genetic anticipation (HP:0003743)	1.74368482
88	Asplenia (HP:0001746)	1.73759787
89	Leukodystrophy (HP:0002415)	1.71598948
90	Depressed nasal ridge (HP:0000457)	1.71336252
91	Anencephaly (HP:0002323)	1.71075096
92	Abnormality of the renal medulla (HP:0100957)	1.70415201
93	Attenuation of retinal blood vessels (HP:0007843)	1.69733770
94	Abnormality of the pulmonary veins (HP:0011718)	1.66978218
95	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.66015455
96	Abnormality of urine glucose concentration (HP:0011016)	1.64445105
97	Glycosuria (HP:0003076)	1.64445105
98	Exertional dyspnea (HP:0002875)	1.63490575
99	Increased muscle lipid content (HP:0009058)	1.62394438
100	Polyuria (HP:0000103)	1.62213641

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	7.45202315
2	MAP3K13	7.09723874
3	PASK	3.90545177
4	PIK3CA	3.00481109
5	TXK	2.64741345
6	ZAK	2.06170996
7	CAMKK1	2.01009275
8	LIMK1	1.97937757
9	ADRBK2	1.90376963
10	VRK2	1.85186672
11	CAMKK2	1.80189295
12	PTK6	1.78183755
13	CDK19	1.78145354
14	TAOK3	1.65665668
15	BMPR2	1.63440544
16	WNK4	1.61306690
17	ARAF	1.58644965
18	MAP4K1	1.40873738
19	MAP3K9	1.40273378
20	GRK1	1.34416302
21	MAP4K2	1.33454845
22	PINK1	1.25643148
23	MAP3K14	1.18050410
24	MOS	1.17982971
25	STK16	1.17954328
26	DYRK2	1.15566559
27	VRK1	1.13312033
28	NUAK1	1.05138654
29	IKBKB	0.94185673
30	BRSK1	0.90369420
31	STK39	0.90026971
32	LRRK2	0.89776834
33	GRK7	0.89203590
34	FRK	0.86569981
35	WNK3	0.85889861
36	BRAF	0.85832214
37	OXSR1	0.83606743
38	KIT	0.81077737
39	NEK2	0.81006402
40	MAP3K12	0.79671279
41	RIPK4	0.78953416
42	MAP3K11	0.77745771
43	BTK	0.76973512
44	PRKCQ	0.75968743
45	PRKCG	0.75545742
46	TIE1	0.68848508
47	INSRR	0.67273195
48	CSNK1G2	0.66333457
49	ADRBK1	0.66117866
50	NEK1	0.66082663
51	CSNK1G3	0.63379338
52	ILK	0.62216027
53	LYN	0.59406956
54	TEC	0.59371665
55	SYK	0.58427080
56	NME2	0.57357037
57	BMPR1B	0.55805702
58	AURKA	0.55623760
59	CAMK1D	0.54732382
60	DAPK3	0.53232214
61	MAP2K6	0.51788149
62	CDK8	0.49692451
63	KDR	0.49266593
64	EPHB2	0.48859035
65	MINK1	0.48844313
66	OBSCN	0.47670669
67	NME1	0.47410847
68	EPHA4	0.47162649
69	GRK5	0.45785209
70	BCKDK	0.42939846
71	RPS6KA5	0.42322353
72	CSNK2A2	0.41714491
73	BRSK2	0.39304504
74	LCK	0.39013565
75	TAF1	0.38213042
76	CHUK	0.38067871
77	ITK	0.37410500
78	CSNK1G1	0.36443513
79	PRKACA	0.36278522
80	PRKCZ	0.33549476
81	CSNK2A1	0.33027883
82	CAMK1	0.32709737
83	NTRK2	0.31360241
84	AURKB	0.31180332
85	CSNK1A1L	0.30616637
86	ATR	0.29386954
87	STK38L	0.29277090
88	MYLK	0.29119632
89	TYRO3	0.29030792
90	PLK1	0.27569388
91	MAPK13	0.27331414
92	MAP3K7	0.26603209
93	PAK1	0.25658557
94	MAP2K4	0.24852226
95	PRKCA	0.24547848
96	STK11	0.24524910
97	MUSK	0.23118971
98	MAP3K8	0.23086679
99	IGF1R	0.21819196
100	MAP3K4	0.21526038

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.76011003
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.80013028
3	Parkinsons disease_Homo sapiens_hsa05012	3.16230872
4	Allograft rejection_Homo sapiens_hsa05330	2.90443372
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.85768467
6	Caffeine metabolism_Homo sapiens_hsa00232	2.81310745
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.78721249
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.70971755
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.55366772
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.42798781
11	Asthma_Homo sapiens_hsa05310	2.12622770
12	Huntingtons disease_Homo sapiens_hsa05016	1.99460439
13	RNA polymerase_Homo sapiens_hsa03020	1.98697718
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.97996094
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.96762404
16	Alzheimers disease_Homo sapiens_hsa05010	1.96412908
17	Proteasome_Homo sapiens_hsa03050	1.88215460
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.86582760
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.85679802
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.69652213
21	Protein export_Homo sapiens_hsa03060	1.57281503
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.49405526
23	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.45739457
24	Homologous recombination_Homo sapiens_hsa03440	1.40520919
25	Antigen processing and presentation_Homo sapiens_hsa04612	1.22597271
26	Phototransduction_Homo sapiens_hsa04744	1.22152316
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.17018076
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13070923
29	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.03827608
30	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.03101141
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.00729993
32	Nicotine addiction_Homo sapiens_hsa05033	1.00720904
33	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.99915687
34	Pyrimidine metabolism_Homo sapiens_hsa00240	0.97638968
35	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97280859
36	Rheumatoid arthritis_Homo sapiens_hsa05323	0.94659639
37	African trypanosomiasis_Homo sapiens_hsa05143	0.90764626
38	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.88738264
39	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.88690056
40	Fat digestion and absorption_Homo sapiens_hsa04975	0.85928746
41	RNA degradation_Homo sapiens_hsa03018	0.85785527
42	Nitrogen metabolism_Homo sapiens_hsa00910	0.85510799
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.85451512
44	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.84645081
45	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.84569437
46	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.84530491
47	Olfactory transduction_Homo sapiens_hsa04740	0.80730283
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.78786017
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.76575448
50	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.72696158
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.72131572
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.70048258
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69390682
54	Retinol metabolism_Homo sapiens_hsa00830	0.66411742
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.65735492
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.62008981
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61120625
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60155640
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60146534
60	Regulation of autophagy_Homo sapiens_hsa04140	0.51148287
61	Fanconi anemia pathway_Homo sapiens_hsa03460	0.51038289
62	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.49794107
63	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.48562866
64	Metabolic pathways_Homo sapiens_hsa01100	0.48371989
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46120871
66	Steroid biosynthesis_Homo sapiens_hsa00100	0.44910055
67	Alcoholism_Homo sapiens_hsa05034	0.44841005
68	Viral myocarditis_Homo sapiens_hsa05416	0.44638675
69	Spliceosome_Homo sapiens_hsa03040	0.43670243
70	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.43487014
71	Peroxisome_Homo sapiens_hsa04146	0.43435332
72	Butanoate metabolism_Homo sapiens_hsa00650	0.41927743
73	Basal transcription factors_Homo sapiens_hsa03022	0.40500258
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39116698
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.38815830
76	Purine metabolism_Homo sapiens_hsa00230	0.38393127
77	Insulin secretion_Homo sapiens_hsa04911	0.37690755
78	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.37008972
79	Fatty acid degradation_Homo sapiens_hsa00071	0.35618019
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33478801
81	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.33260122
82	Tyrosine metabolism_Homo sapiens_hsa00350	0.32114237
83	DNA replication_Homo sapiens_hsa03030	0.31551476
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.30959786
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30144002
86	Malaria_Homo sapiens_hsa05144	0.28332801
87	Base excision repair_Homo sapiens_hsa03410	0.27359694
88	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.22760149
89	Mineral absorption_Homo sapiens_hsa04978	0.20547435
90	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.20013354
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.19661124
92	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.17775659
93	Type II diabetes mellitus_Homo sapiens_hsa04930	0.16703048
94	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.16339174
95	Taste transduction_Homo sapiens_hsa04742	0.15036896
96	Apoptosis_Homo sapiens_hsa04210	0.14846325
97	Basal cell carcinoma_Homo sapiens_hsa05217	0.13735593
98	Morphine addiction_Homo sapiens_hsa05032	0.13269876
99	Glutathione metabolism_Homo sapiens_hsa00480	0.12731111
100	p53 signaling pathway_Homo sapiens_hsa04115	0.12664759

RPL31P63

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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