ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.66697328
2	viral transcription (GO:0019083)	5.24180628
3	translational termination (GO:0006415)	4.93240248
4	ATP synthesis coupled proton transport (GO:0015986)	4.67066670
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.67066670
6	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.51037843
7	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.51037843
8	translational elongation (GO:0006414)	4.40275955
9	DNA deamination (GO:0045006)	4.34490924
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.25752051
11	cotranslational protein targeting to membrane (GO:0006613)	4.15840653
12	protein targeting to ER (GO:0045047)	4.13563244
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.12324502
14	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.06214400
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.02769151
16	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.98831202
17	maturation of SSU-rRNA (GO:0030490)	3.98011443
18	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.92991014
19	protein localization to endoplasmic reticulum (GO:0070972)	3.91091855
20	ribosomal small subunit biogenesis (GO:0042274)	3.86101825
21	behavioral response to nicotine (GO:0035095)	3.82332326
22	viral life cycle (GO:0019058)	3.74768890
23	ribosomal large subunit biogenesis (GO:0042273)	3.72389124
24	chaperone-mediated protein transport (GO:0072321)	3.69834635
25	protein complex biogenesis (GO:0070271)	3.65408810
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.58952268
27	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.58952268
28	NADH dehydrogenase complex assembly (GO:0010257)	3.58952268
29	cellular protein complex disassembly (GO:0043624)	3.55898093
30	respiratory chain complex IV assembly (GO:0008535)	3.53426013
31	ubiquinone biosynthetic process (GO:0006744)	3.45672912
32	electron transport chain (GO:0022900)	3.43093334
33	respiratory electron transport chain (GO:0022904)	3.40322085
34	protein neddylation (GO:0045116)	3.39258954
35	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.34050848
36	adenosine metabolic process (GO:0046085)	3.26745193
37	GTP biosynthetic process (GO:0006183)	3.26007140
38	mitochondrial respiratory chain complex assembly (GO:0033108)	3.18740010
39	translational initiation (GO:0006413)	3.15608532
40	cytochrome complex assembly (GO:0017004)	3.11161230
41	sequestering of actin monomers (GO:0042989)	3.08818121
42	water-soluble vitamin biosynthetic process (GO:0042364)	3.08066847
43	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.06962897
44	S-adenosylmethionine metabolic process (GO:0046500)	3.01695166
45	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.00011094
46	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.99781718
47	ubiquinone metabolic process (GO:0006743)	2.98913957
48	positive regulation of prostaglandin secretion (GO:0032308)	2.98151432
49	ATP biosynthetic process (GO:0006754)	2.91500006
50	protein complex disassembly (GO:0043241)	2.89972642
51	cytidine deamination (GO:0009972)	2.88120212
52	cytidine metabolic process (GO:0046087)	2.88120212
53	cytidine catabolic process (GO:0006216)	2.88120212
54	kynurenine metabolic process (GO:0070189)	2.88023547
55	translation (GO:0006412)	2.87011741
56	cellular component biogenesis (GO:0044085)	2.85680806
57	piRNA metabolic process (GO:0034587)	2.82759863
58	platelet dense granule organization (GO:0060155)	2.80665778
59	negative regulation of telomere maintenance (GO:0032205)	2.78664935
60	macromolecular complex disassembly (GO:0032984)	2.78118686
61	response to interferon-beta (GO:0035456)	2.76972276
62	positive regulation of defense response to virus by host (GO:0002230)	2.75621414
63	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.74750778
64	termination of RNA polymerase III transcription (GO:0006386)	2.74750778
65	quinone biosynthetic process (GO:1901663)	2.72989658
66	tryptophan catabolic process (GO:0006569)	2.72974115
67	indole-containing compound catabolic process (GO:0042436)	2.72974115
68	indolalkylamine catabolic process (GO:0046218)	2.72974115
69	GPI anchor metabolic process (GO:0006505)	2.72445013
70	regulation of antigen processing and presentation (GO:0002577)	2.69104871
71	negative T cell selection (GO:0043383)	2.68317948
72	ribonucleoprotein complex biogenesis (GO:0022613)	2.66919062
73	UTP biosynthetic process (GO:0006228)	2.66531004
74	indolalkylamine metabolic process (GO:0006586)	2.66491332
75	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.66391719
76	sleep (GO:0030431)	2.65853134
77	protein-cofactor linkage (GO:0018065)	2.63717979
78	aldehyde catabolic process (GO:0046185)	2.63589901
79	mast cell activation (GO:0045576)	2.62362725
80	response to pheromone (GO:0019236)	2.62316811
81	protein targeting to membrane (GO:0006612)	2.62113227
82	regulation of hypersensitivity (GO:0002883)	2.61092458
83	negative regulation of T cell differentiation in thymus (GO:0033085)	2.60949244
84	tryptophan metabolic process (GO:0006568)	2.60536138
85	GPI anchor biosynthetic process (GO:0006506)	2.59116984
86	UTP metabolic process (GO:0046051)	2.58311522
87	hydrogen ion transmembrane transport (GO:1902600)	2.57820849
88	hydrogen transport (GO:0006818)	2.57047051
89	proton transport (GO:0015992)	2.56716088
90	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.54418281
91	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.53738563
92	preassembly of GPI anchor in ER membrane (GO:0016254)	2.53608343
93	positive regulation of antigen processing and presentation (GO:0002579)	2.53439491
94	negative thymic T cell selection (GO:0045060)	2.52970539
95	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.52282751
96	mannosylation (GO:0097502)	2.51412704
97	positive regulation of activated T cell proliferation (GO:0042104)	2.50749583
98	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.46469726
99	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.45225809
100	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.44897134

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.31121588
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.64602324
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.40610570
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.36090290
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.91439011
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.84794670
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.68489364
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.66475093
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.55204007
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.46106165
11	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.34553815
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.34269540
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.14139413
14	VDR_22108803_ChIP-Seq_LS180_Human	2.11179272
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.01080266
16	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.00966784
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.99593645
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.86305553
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75735721
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.75289297
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.72871567
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.71469474
23	TP53_22573176_ChIP-Seq_HFKS_Human	1.66656122
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.63927092
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61213941
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.50629855
27	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.48329504
28	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.47803670
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.47371231
30	AR_20517297_ChIP-Seq_VCAP_Human	1.46114757
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.42855789
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.41897119
33	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.41780035
34	GATA3_26560356_Chip-Seq_TH2_Human	1.36640770
35	TAF2_19829295_ChIP-Seq_ESCs_Human	1.36156129
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35123422
37	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.33062653
38	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.31859799
39	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.31839482
40	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.30973091
41	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.30708239
42	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27886644
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.27852001
44	NANOG_20526341_ChIP-Seq_ESCs_Human	1.27847701
45	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.27592725
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26767634
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26767634
48	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.25940667
49	NCOR_22424771_ChIP-Seq_293T_Human	1.24812530
50	STAT1_20625510_ChIP-Seq_HELA_Human	1.23730248
51	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.23361660
52	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.23188958
53	IGF1R_20145208_ChIP-Seq_DFB_Human	1.22460457
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.20700506
55	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.20159868
56	BCL6_27268052_Chip-Seq_Bcells_Human	1.17811585
57	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.16725000
58	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.14217446
59	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.14173208
60	EWS_26573619_Chip-Seq_HEK293_Human	1.13570254
61	P300_27268052_Chip-Seq_Bcells_Human	1.13155522
62	FUS_26573619_Chip-Seq_HEK293_Human	1.11214113
63	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.09279289
64	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09062862
65	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.08289274
66	ER_23166858_ChIP-Seq_MCF-7_Human	1.07009027
67	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.04926311
68	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04570063
69	MYC_19829295_ChIP-Seq_ESCs_Human	1.04447928
70	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.03472768
71	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.02957229
72	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02871453
73	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.01985403
74	ERG_20517297_ChIP-Seq_VCAP_Human	1.01749570
75	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.01594039
76	ERA_21632823_ChIP-Seq_H3396_Human	1.01143954
77	P300_19829295_ChIP-Seq_ESCs_Human	1.01102373
78	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.98027886
79	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.97024529
80	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96692289
81	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.96407584
82	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95989275
83	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95765588
84	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.95592300
85	E2F1_20622854_ChIP-Seq_HELA_Human	0.95182310
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94606550
87	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.94524029
88	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.93989741
89	CBP_20019798_ChIP-Seq_JUKART_Human	0.93989741
90	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.93779149
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.93727074
92	SOX2_19829295_ChIP-Seq_ESCs_Human	0.93727074
93	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.92902792
94	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.92618232
95	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.91400322
96	GATA3_27048872_Chip-Seq_THYMUS_Human	0.90525233
97	TCF4_22108803_ChIP-Seq_LS180_Human	0.90445435
98	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.90293926
99	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.89961602
100	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.89801717

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.15750081
2	MP0005671_abnormal_response_to	2.93359752
3	MP0002837_dystrophic_cardiac_calcinosis	2.86403409
4	MP0001835_abnormal_antigen_presentation	2.74561570
5	MP0009379_abnormal_foot_pigmentation	2.66698908
6	MP0005646_abnormal_pituitary_gland	2.64835716
7	MP0002102_abnormal_ear_morphology	2.33742175
8	MP0001986_abnormal_taste_sensitivity	2.30049331
9	MP0006072_abnormal_retinal_apoptosis	2.27826685
10	MP0002138_abnormal_hepatobiliary_system	2.23176012
11	MP0004885_abnormal_endolymph	2.16361213
12	MP0008875_abnormal_xenobiotic_pharmacok	2.15379680
13	MP0004145_abnormal_muscle_electrophysio	2.08562664
14	MP0008872_abnormal_physiological_respon	2.04949545
15	MP0004147_increased_porphyrin_level	2.02455503
16	MP0001968_abnormal_touch/_nociception	2.00918258
17	MP0002653_abnormal_ependyma_morphology	1.97884147
18	MP0003646_muscle_fatigue	1.84548146
19	MP0003878_abnormal_ear_physiology	1.74694856
20	MP0005377_hearing/vestibular/ear_phenot	1.74694856
21	MP0003195_calcinosis	1.72879187
22	MP0002148_abnormal_hypersensitivity_rea	1.67000127
23	MP0003724_increased_susceptibility_to	1.66960548
24	MP0001800_abnormal_humoral_immune	1.65322552
25	MP0005551_abnormal_eye_electrophysiolog	1.64522826
26	MP0005645_abnormal_hypothalamus_physiol	1.62205076
27	MP0004142_abnormal_muscle_tone	1.59672659
28	MP0002736_abnormal_nociception_after	1.59288840
29	MP0000372_irregular_coat_pigmentation	1.58471768
30	MP0002876_abnormal_thyroid_physiology	1.57369392
31	MP0008995_early_reproductive_senescence	1.53954382
32	MP0002163_abnormal_gland_morphology	1.53764025
33	MP0005000_abnormal_immune_tolerance	1.51834286
34	MP0003186_abnormal_redox_activity	1.47246484
35	MP0004043_abnormal_pH_regulation	1.46076863
36	MP0002723_abnormal_immune_serum	1.42483137
37	MP0009785_altered_susceptibility_to	1.40208810
38	MP0008877_abnormal_DNA_methylation	1.34368547
39	MP0003787_abnormal_imprinting	1.34252473
40	MP0005360_urolithiasis	1.33434583
41	MP0003786_premature_aging	1.30028371
42	MP0008789_abnormal_olfactory_epithelium	1.27647400
43	MP0001905_abnormal_dopamine_level	1.26691573
44	MP0006276_abnormal_autonomic_nervous	1.26314404
45	MP0005253_abnormal_eye_physiology	1.25664011
46	MP0001661_extended_life_span	1.22769348
47	MP0006054_spinal_hemorrhage	1.21986464
48	MP0002452_abnormal_antigen_presenting	1.21428807
49	MP0005389_reproductive_system_phenotype	1.18139747
50	MP0009764_decreased_sensitivity_to	1.17126719
51	MP0005075_abnormal_melanosome_morpholog	1.15218173
52	MP0008775_abnormal_heart_ventricle	1.14948718
53	MP0002272_abnormal_nervous_system	1.13865629
54	MP0002160_abnormal_reproductive_system	1.10988226
55	MP0002420_abnormal_adaptive_immunity	1.09126316
56	MP0003011_delayed_dark_adaptation	1.08303454
57	MP0002234_abnormal_pharynx_morphology	1.06986269
58	MP0001819_abnormal_immune_cell	1.06835495
59	MP0002277_abnormal_respiratory_mucosa	1.06240451
60	MP0009745_abnormal_behavioral_response	1.06209615
61	MP0000685_abnormal_immune_system	1.06186569
62	MP0003806_abnormal_nucleotide_metabolis	1.02503108
63	MP0001486_abnormal_startle_reflex	1.02417275
64	MP0001440_abnormal_grooming_behavior	1.02008815
65	MP0001501_abnormal_sleep_pattern	1.00213723
66	MP0001764_abnormal_homeostasis	0.98824615
67	MP0006036_abnormal_mitochondrial_physio	0.98697719
68	MP0004742_abnormal_vestibular_system	0.98129586
69	MP0002006_tumorigenesis	0.97809594
70	MP0003252_abnormal_bile_duct	0.93957899
71	MP0002733_abnormal_thermal_nociception	0.93421240
72	MP0002166_altered_tumor_susceptibility	0.92764803
73	MP0003866_abnormal_defecation	0.91956878
74	MP0005379_endocrine/exocrine_gland_phen	0.91695166
75	MP0005332_abnormal_amino_acid	0.91132770
76	MP0009333_abnormal_splenocyte_physiolog	0.90935045
77	MP0001919_abnormal_reproductive_system	0.90706633
78	MP0010155_abnormal_intestine_physiology	0.89789279
79	MP0002735_abnormal_chemical_nociception	0.89594519
80	MP0003880_abnormal_central_pattern	0.89182540
81	MP0001485_abnormal_pinna_reflex	0.88788064
82	MP0005410_abnormal_fertilization	0.88007015
83	MP0005084_abnormal_gallbladder_morpholo	0.87970779
84	MP0000678_abnormal_parathyroid_gland	0.87359006
85	MP0001970_abnormal_pain_threshold	0.87132074
86	MP0005387_immune_system_phenotype	0.87120891
87	MP0001790_abnormal_immune_system	0.87120891
88	MP0000631_abnormal_neuroendocrine_gland	0.85767184
89	MP0002095_abnormal_skin_pigmentation	0.84041085
90	MP0001765_abnormal_ion_homeostasis	0.82454839
91	MP0001845_abnormal_inflammatory_respons	0.82368388
92	MP0004133_heterotaxia	0.79106339
93	MP0005025_abnormal_response_to	0.79089462
94	MP0005636_abnormal_mineral_homeostasis	0.78939057
95	MP0005394_taste/olfaction_phenotype	0.78740901
96	MP0005499_abnormal_olfactory_system	0.78740901
97	MP0004130_abnormal_muscle_cell	0.77391343
98	MP0000230_abnormal_systemic_arterial	0.77337667
99	MP0000516_abnormal_urinary_system	0.76608213
100	MP0005367_renal/urinary_system_phenotyp	0.76608213

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.14353608
2	Mitochondrial inheritance (HP:0001427)	4.09217972
3	Elevated erythrocyte sedimentation rate (HP:0003565)	3.97349087
4	Hepatocellular necrosis (HP:0001404)	3.87511778
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.78636983
6	Pancreatic cysts (HP:0001737)	3.65091128
7	Increased CSF lactate (HP:0002490)	3.56185576
8	Abnormality of cells of the erythroid lineage (HP:0012130)	3.55864712
9	Increased hepatocellular lipid droplets (HP:0006565)	3.55320032
10	Progressive macrocephaly (HP:0004481)	3.52553309
11	Pancreatic fibrosis (HP:0100732)	3.46495145
12	Lipid accumulation in hepatocytes (HP:0006561)	3.43290732
13	Abnormal number of erythroid precursors (HP:0012131)	3.41815208
14	Acute encephalopathy (HP:0006846)	3.39627752
15	Chronic hepatic failure (HP:0100626)	3.33018258
16	Hepatic necrosis (HP:0002605)	3.21778393
17	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.18717448
18	3-Methylglutaconic aciduria (HP:0003535)	3.06722113
19	True hermaphroditism (HP:0010459)	3.02402432
20	Abolished electroretinogram (ERG) (HP:0000550)	2.99522625
21	Reticulocytopenia (HP:0001896)	2.99293150
22	Congenital stationary night blindness (HP:0007642)	2.90526064
23	Renal Fanconi syndrome (HP:0001994)	2.89496825
24	Increased intramyocellular lipid droplets (HP:0012240)	2.85922332
25	IgG deficiency (HP:0004315)	2.83040828
26	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.78162371
27	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.78162371
28	Pendular nystagmus (HP:0012043)	2.75833329
29	Absent/shortened dynein arms (HP:0200106)	2.72978776
30	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.72978776
31	Exertional dyspnea (HP:0002875)	2.68168137
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.67086648
33	Cerebral edema (HP:0002181)	2.67064708
34	Severe combined immunodeficiency (HP:0004430)	2.58391650
35	Keratoconus (HP:0000563)	2.56554830
36	Increased corneal curvature (HP:0100692)	2.56554830
37	Molar tooth sign on MRI (HP:0002419)	2.55929725
38	Abnormality of midbrain morphology (HP:0002418)	2.55929725
39	Type II lissencephaly (HP:0007260)	2.55366883
40	Increased serum lactate (HP:0002151)	2.54215758
41	Lactic acidosis (HP:0003128)	2.52793272
42	Progressive inability to walk (HP:0002505)	2.50567922
43	Optic disc pallor (HP:0000543)	2.49116414
44	Nephronophthisis (HP:0000090)	2.44894694
45	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.44506469
46	Increased muscle lipid content (HP:0009058)	2.44476822
47	Abnormal rod and cone electroretinograms (HP:0008323)	2.41853380
48	Congenital, generalized hypertrichosis (HP:0004540)	2.41392857
49	Constricted visual fields (HP:0001133)	2.39956857
50	Attenuation of retinal blood vessels (HP:0007843)	2.36946161
51	Cystic liver disease (HP:0006706)	2.36861839
52	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.34470133
53	Methylmalonic acidemia (HP:0002912)	2.26448171
54	Abnormality of the prostate (HP:0008775)	2.26212748
55	Macrocytic anemia (HP:0001972)	2.22861626
56	Abnormality of the renal medulla (HP:0100957)	2.21413712
57	Abnormality of DNA repair (HP:0003254)	2.21399843
58	Thyroiditis (HP:0100646)	2.18585994
59	Sclerocornea (HP:0000647)	2.16213155
60	Abnormality of the renal cortex (HP:0011035)	2.15438437
61	Type 2 muscle fiber atrophy (HP:0003554)	2.14616805
62	Decreased central vision (HP:0007663)	2.14546012
63	Polydipsia (HP:0001959)	2.08514889
64	Abnormal drinking behavior (HP:0030082)	2.08514889
65	Asplenia (HP:0001746)	2.08011709
66	Stomatitis (HP:0010280)	2.07843162
67	Pallor (HP:0000980)	2.07774323
68	Chorioretinal atrophy (HP:0000533)	2.07543525
69	Abnormal respiratory motile cilium morphology (HP:0005938)	2.07500252
70	Abnormal respiratory epithelium morphology (HP:0012253)	2.07500252
71	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.05717530
72	Panhypogammaglobulinemia (HP:0003139)	2.05478464
73	Aplasia/hypoplasia of the uterus (HP:0008684)	2.03436413
74	Respiratory failure (HP:0002878)	2.02564986
75	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.00088422
76	Abnormality of alanine metabolism (HP:0010916)	2.00088422
77	Hyperalaninemia (HP:0003348)	2.00088422
78	Aplastic anemia (HP:0001915)	1.94399280
79	Hypoproteinemia (HP:0003075)	1.92991469
80	Leukodystrophy (HP:0002415)	1.92716659
81	Abnormal biliary tract physiology (HP:0012439)	1.90432911
82	Bile duct proliferation (HP:0001408)	1.90432911
83	Pancytopenia (HP:0001876)	1.85521697
84	Absent thumb (HP:0009777)	1.85451268
85	Hypoplasia of the uterus (HP:0000013)	1.84561672
86	Lethargy (HP:0001254)	1.83703438
87	Hypomagnesemia (HP:0002917)	1.82399218
88	Inability to walk (HP:0002540)	1.81499120
89	Polyuria (HP:0000103)	1.81214549
90	Abnormality of urine glucose concentration (HP:0011016)	1.80883556
91	Glycosuria (HP:0003076)	1.80883556
92	Anencephaly (HP:0002323)	1.79293899
93	Combined immunodeficiency (HP:0005387)	1.78123693
94	Methylmalonic aciduria (HP:0012120)	1.74474792
95	Congenital hepatic fibrosis (HP:0002612)	1.73787990
96	Abnormality of renal resorption (HP:0011038)	1.72970014
97	Agitation (HP:0000713)	1.72191856
98	Exercise intolerance (HP:0003546)	1.71237839
99	Hyperphosphaturia (HP:0003109)	1.71057767
100	Type I transferrin isoform profile (HP:0003642)	1.70067490

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.02467107
2	TXK	3.48888589
3	PASK	3.42543257
4	WNK4	2.70760231
5	CDK19	2.61542061
6	TLK1	2.53281896
7	ADRBK2	2.52146490
8	MAP4K2	2.50211027
9	BCKDK	2.31509430
10	FRK	2.28794507
11	STK16	2.17472032
12	NUAK1	2.13243675
13	GRK1	2.06876156
14	FES	1.99155701
15	MAP3K13	1.92542557
16	MAP4K1	1.86414639
17	ZAK	1.79539572
18	CAMKK1	1.76022500
19	OXSR1	1.71762252
20	TEC	1.66865904
21	KDR	1.66629470
22	KIT	1.60467139
23	IKBKB	1.57534258
24	ITK	1.56956013
25	BMPR2	1.53708986
26	MAPKAPK3	1.34373472
27	SYK	1.28084643
28	BTK	1.25682952
29	STK39	1.23509195
30	PHKG2	1.21954496
31	PHKG1	1.21954496
32	MAP3K14	1.18286449
33	JAK3	1.17015873
34	WNK3	1.16486558
35	PIK3CA	1.14125850
36	CAMKK2	1.10784481
37	TIE1	1.09795610
38	DYRK2	1.03782999
39	PINK1	1.01105361
40	MUSK	1.01042587
41	GRK6	0.96844099
42	ERBB3	0.93477657
43	RIPK4	0.91357319
44	PRKCQ	0.91133769
45	LYN	0.86603118
46	VRK2	0.85357367
47	LRRK2	0.84181290
48	IKBKE	0.83981670
49	LCK	0.83965729
50	MAP2K2	0.83033732
51	MAP3K4	0.82992380
52	CSF1R	0.81904624
53	MST4	0.80443951
54	BMPR1B	0.77763878
55	MAPK13	0.77659158
56	INSRR	0.77168480
57	ADRBK1	0.76955896
58	DAPK2	0.76714445
59	SIK2	0.74957560
60	MAP3K12	0.73066730
61	MATK	0.65038204
62	TESK2	0.63428111
63	IGF1R	0.59041393
64	CSNK1G3	0.58198736
65	OBSCN	0.56420815
66	CSNK1G2	0.55944417
67	RPS6KA5	0.53667169
68	MYLK	0.52876776
69	LIMK1	0.51495584
70	RPS6KB2	0.51382298
71	PRKCE	0.49933179
72	TRPM7	0.49651093
73	VRK1	0.49100123
74	PRKCA	0.48801801
75	NME1	0.48786745
76	EIF2AK3	0.48493475
77	CAMK1	0.48209189
78	PRKACA	0.47675647
79	PRKCD	0.45031530
80	ABL1	0.42308590
81	TBK1	0.41328739
82	CSNK1G1	0.41097798
83	DAPK1	0.40375926
84	NEK2	0.38611008
85	PAK6	0.37500029
86	PRKCG	0.37194833
87	CSNK2A2	0.36339601
88	GRK7	0.35791841
89	MAPKAPK5	0.33923857
90	HCK	0.33759863
91	CHUK	0.33490105
92	ATR	0.33446577
93	FLT3	0.32082830
94	CSNK1A1	0.31918069
95	CSNK2A1	0.31853313
96	GRK5	0.30760235
97	AURKA	0.30499215
98	DAPK3	0.30287057
99	MAP2K6	0.30181208
100	PIM1	0.29484839

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.15689409
2	Asthma_Homo sapiens_hsa05310	4.05149689
3	Allograft rejection_Homo sapiens_hsa05330	3.35912791
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.27240863
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.20955072
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.12718871
7	Graft-versus-host disease_Homo sapiens_hsa05332	3.09699830
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.77843833
9	Parkinsons disease_Homo sapiens_hsa05012	2.70977244
10	RNA polymerase_Homo sapiens_hsa03020	1.93983750
11	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.93321746
12	Proteasome_Homo sapiens_hsa03050	1.92101214
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.91178451
14	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.86329092
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.81712235
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.74668017
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.74131409
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.70588660
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.70274313
20	Alzheimers disease_Homo sapiens_hsa05010	1.64523369
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.62736223
22	Phototransduction_Homo sapiens_hsa04744	1.55781916
23	Antigen processing and presentation_Homo sapiens_hsa04612	1.55328672
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.52435958
25	One carbon pool by folate_Homo sapiens_hsa00670	1.48832624
26	Huntingtons disease_Homo sapiens_hsa05016	1.48416398
27	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.44076378
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.34794486
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.33566736
30	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.24993038
31	Viral myocarditis_Homo sapiens_hsa05416	1.13640718
32	Homologous recombination_Homo sapiens_hsa03440	1.08740258
33	Protein export_Homo sapiens_hsa03060	1.01457287
34	Peroxisome_Homo sapiens_hsa04146	1.00903236
35	Sulfur metabolism_Homo sapiens_hsa00920	1.00821439
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00783167
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96374648
38	Tryptophan metabolism_Homo sapiens_hsa00380	0.95015160
39	Fanconi anemia pathway_Homo sapiens_hsa03460	0.93549431
40	Leishmaniasis_Homo sapiens_hsa05140	0.92891259
41	RNA degradation_Homo sapiens_hsa03018	0.92024070
42	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.90749545
43	Olfactory transduction_Homo sapiens_hsa04740	0.85460078
44	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.84551874
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.83406309
46	Purine metabolism_Homo sapiens_hsa00230	0.81489904
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.80402820
48	Morphine addiction_Homo sapiens_hsa05032	0.77758987
49	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.77610347
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.77519077
51	Nucleotide excision repair_Homo sapiens_hsa03420	0.75792409
52	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.73601834
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73355561
54	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.72957121
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.70756514
56	Propanoate metabolism_Homo sapiens_hsa00640	0.68106795
57	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.66821062
58	Butanoate metabolism_Homo sapiens_hsa00650	0.66281704
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.65861836
60	Selenocompound metabolism_Homo sapiens_hsa00450	0.64169243
61	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.61824713
62	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.61102230
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.60276065
64	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57180938
65	Sulfur relay system_Homo sapiens_hsa04122	0.56787909
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56511826
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56420998
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.54918853
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.54349118
70	Regulation of autophagy_Homo sapiens_hsa04140	0.54273278
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.54219045
72	Caffeine metabolism_Homo sapiens_hsa00232	0.53574551
73	Nicotine addiction_Homo sapiens_hsa05033	0.53301601
74	Retinol metabolism_Homo sapiens_hsa00830	0.52152040
75	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.51657611
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.51471959
77	Metabolic pathways_Homo sapiens_hsa01100	0.51400714
78	DNA replication_Homo sapiens_hsa03030	0.50966876
79	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.50149420
80	Serotonergic synapse_Homo sapiens_hsa04726	0.49828609
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.49306161
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49173648
83	GABAergic synapse_Homo sapiens_hsa04727	0.48479967
84	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43482049
85	Taste transduction_Homo sapiens_hsa04742	0.40791345
86	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.38587371
87	Herpes simplex infection_Homo sapiens_hsa05168	0.37370083
88	Basal transcription factors_Homo sapiens_hsa03022	0.35377611
89	Spliceosome_Homo sapiens_hsa03040	0.34728876
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33231155
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.32852854
92	Glycerolipid metabolism_Homo sapiens_hsa00561	0.30933084
93	Mismatch repair_Homo sapiens_hsa03430	0.29826128
94	Circadian entrainment_Homo sapiens_hsa04713	0.28887470
95	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.28438440
96	Base excision repair_Homo sapiens_hsa03410	0.27828919
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.25691723
98	Salivary secretion_Homo sapiens_hsa04970	0.23239965
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.22960935
100	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.22703547

RPL31P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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