ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular response to exogenous dsRNA (GO:0071360)	4.59924688
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.56445098
3	ATP synthesis coupled proton transport (GO:0015986)	4.56445098
4	ribosomal small subunit assembly (GO:0000028)	4.20072941
5	DNA deamination (GO:0045006)	3.98510475
6	negative regulation of B cell apoptotic process (GO:0002903)	3.97868756
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.92026614
8	response to interferon-beta (GO:0035456)	3.91597571
9	cellular response to interferon-beta (GO:0035458)	3.89131826
10	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.74209874
11	piRNA metabolic process (GO:0034587)	3.73325433
12	negative regulation of telomere maintenance (GO:0032205)	3.49223466
13	viral transcription (GO:0019083)	3.42618114
14	regulation of B cell apoptotic process (GO:0002902)	3.36394866
15	ubiquinone biosynthetic process (GO:0006744)	3.35303462
16	immunoglobulin mediated immune response (GO:0016064)	3.35044610
17	protein neddylation (GO:0045116)	3.29697717
18	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.26443030
19	translational termination (GO:0006415)	3.24791461
20	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.22778169
21	NAD biosynthetic process (GO:0009435)	3.21934248
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.19550010
23	positive regulation of interleukin-17 production (GO:0032740)	3.17279996
24	respiratory chain complex IV assembly (GO:0008535)	3.16261743
25	purine-containing compound salvage (GO:0043101)	3.15068967
26	behavioral response to nicotine (GO:0035095)	3.12156659
27	purine nucleotide salvage (GO:0032261)	3.10834324
28	protein-cofactor linkage (GO:0018065)	3.09046183
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.06687602
30	NADH dehydrogenase complex assembly (GO:0010257)	3.06687602
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.06687602
32	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.06559762
33	electron transport chain (GO:0022900)	3.04956569
34	respiratory electron transport chain (GO:0022904)	3.04127144
35	ribosomal large subunit biogenesis (GO:0042273)	3.04034319
36	proteasome assembly (GO:0043248)	3.03991707
37	GMP metabolic process (GO:0046037)	3.03318967
38	cotranslational protein targeting to membrane (GO:0006613)	3.00242413
39	translational elongation (GO:0006414)	2.99691399
40	cytidine deamination (GO:0009972)	2.98507500
41	cytidine metabolic process (GO:0046087)	2.98507500
42	cytidine catabolic process (GO:0006216)	2.98507500
43	protein targeting to ER (GO:0045047)	2.97518905
44	pseudouridine synthesis (GO:0001522)	2.96790836
45	maturation of 5.8S rRNA (GO:0000460)	2.94379603
46	preassembly of GPI anchor in ER membrane (GO:0016254)	2.93213383
47	DNA methylation involved in gamete generation (GO:0043046)	2.92857483
48	water-soluble vitamin biosynthetic process (GO:0042364)	2.91143810
49	protein complex biogenesis (GO:0070271)	2.88700404
50	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.87723818
51	ubiquinone metabolic process (GO:0006743)	2.87185517
52	B cell mediated immunity (GO:0019724)	2.87052350
53	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.86861565
54	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.86861565
55	termination of RNA polymerase III transcription (GO:0006386)	2.86694221
56	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.86694221
57	axoneme assembly (GO:0035082)	2.86605587
58	regulation of interleukin-8 secretion (GO:2000482)	2.84665565
59	regulation of regulatory T cell differentiation (GO:0045589)	2.84348028
60	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.81710474
61	mannosylation (GO:0097502)	2.81089249
62	protein localization to endoplasmic reticulum (GO:0070972)	2.78590623
63	quinone biosynthetic process (GO:1901663)	2.78461543
64	rRNA catabolic process (GO:0016075)	2.77184674
65	positive thymic T cell selection (GO:0045059)	2.76905859
66	regulation of isotype switching to IgG isotypes (GO:0048302)	2.75319378
67	cullin deneddylation (GO:0010388)	2.75182936
68	mismatch repair (GO:0006298)	2.74271936
69	GPI anchor metabolic process (GO:0006505)	2.72099809
70	ATP biosynthetic process (GO:0006754)	2.71836357
71	regulation of B cell receptor signaling pathway (GO:0050855)	2.71110250
72	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.67754423
73	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.66834139
74	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.65452886
75	protein deneddylation (GO:0000338)	2.63392343
76	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.63083733
77	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.62988102
78	positive regulation of interleukin-8 secretion (GO:2000484)	2.61798555
79	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.61706916
80	tRNA processing (GO:0008033)	2.58790351
81	hydrogen ion transmembrane transport (GO:1902600)	2.58388259
82	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.58043081
83	nucleotide salvage (GO:0043173)	2.57559312
84	cytochrome complex assembly (GO:0017004)	2.56517919
85	platelet dense granule organization (GO:0060155)	2.55213948
86	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.53532877
87	GPI anchor biosynthetic process (GO:0006506)	2.53198440
88	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.52382648
89	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.51537055
90	fucose catabolic process (GO:0019317)	2.51437045
91	L-fucose metabolic process (GO:0042354)	2.51437045
92	L-fucose catabolic process (GO:0042355)	2.51437045
93	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.51228938
94	translation (GO:0006412)	2.49537028
95	DNA catabolic process, exonucleolytic (GO:0000738)	2.49443874
96	positive regulation of chemokine biosynthetic process (GO:0045080)	2.49429424
97	tRNA modification (GO:0006400)	2.48572603
98	hydrogen transport (GO:0006818)	2.48185930
99	regulation of cilium movement (GO:0003352)	2.47910860
100	mitochondrial respiratory chain complex assembly (GO:0033108)	2.47148094

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	5.07448218
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.26023148
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.83328205
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.64650243
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.47019329
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.36841687
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.85139403
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.79666692
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.75202784
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.71781965
11	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.68616969
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.66904893
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.59144738
14	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.58261831
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.55200495
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.48418738
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.34970012
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.20868769
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.09123272
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.01204061
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.00713311
22	VDR_22108803_ChIP-Seq_LS180_Human	2.00580364
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.91255358
24	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.84523621
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.84060681
26	GATA3_26560356_Chip-Seq_TH2_Human	1.83959540
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.77757572
28	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.68827502
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.59070852
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.54908562
31	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.53497359
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52541220
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.49447810
34	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.43684642
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.43123789
36	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.43078321
37	CIITA_25753668_ChIP-Seq_RAJI_Human	1.42416022
38	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.40388865
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.39997578
40	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.38378642
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.38014399
42	TAF2_19829295_ChIP-Seq_ESCs_Human	1.36405676
43	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.35947470
44	MYC_18940864_ChIP-ChIP_HL60_Human	1.35771152
45	MYB_26560356_Chip-Seq_TH2_Human	1.35617973
46	AR_20517297_ChIP-Seq_VCAP_Human	1.35513876
47	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.34272945
48	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.32265807
49	EWS_26573619_Chip-Seq_HEK293_Human	1.31057244
50	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.30921750
51	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.30817070
52	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.30681352
53	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.28680807
54	SCL_19346495_ChIP-Seq_HPC-7_Human	1.27257953
55	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.27072588
56	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.25622311
57	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23825370
58	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.22270192
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21556170
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21556170
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16555216
62	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.15689316
63	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.15109008
64	DCP1A_22483619_ChIP-Seq_HELA_Human	1.14277635
65	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12985902
66	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.10745893
67	GATA3_27048872_Chip-Seq_THYMUS_Human	1.09052031
68	FUS_26573619_Chip-Seq_HEK293_Human	1.08880160
69	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.08088682
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07533547
71	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07531190
72	CBP_20019798_ChIP-Seq_JUKART_Human	1.07531190
73	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.06831292
74	SPI1_23547873_ChIP-Seq_NB4_Human	1.05881300
75	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.05210861
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98860975
77	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.98351601
78	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.97280595
79	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.96583089
80	ERG_20517297_ChIP-Seq_VCAP_Human	0.96550335
81	SPI1_20517297_ChIP-Seq_HL60_Human	0.96493067
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95482189
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94718363
84	GATA3_26560356_Chip-Seq_TH1_Human	0.91978650
85	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.91953710
86	TTF2_22483619_ChIP-Seq_HELA_Human	0.90963561
87	OCT4_20526341_ChIP-Seq_ESCs_Human	0.90529394
88	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.90359820
89	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.90197902
90	XRN2_22483619_ChIP-Seq_HELA_Human	0.89613486
91	RUNX_20019798_ChIP-Seq_JUKART_Human	0.89430052
92	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.88762734
93	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88690628
94	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.88478972
95	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.88416480
96	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87990086
97	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.87787261
98	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.87342177
99	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.86957143
100	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.86933112

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	3.90462362
2	MP0005671_abnormal_response_to	3.53647354
3	MP0001835_abnormal_antigen_presentation	3.33920667
4	MP0004147_increased_porphyrin_level	3.01425110
5	MP0002166_altered_tumor_susceptibility	2.53340822
6	MP0008877_abnormal_DNA_methylation	2.49411395
7	MP0002148_abnormal_hypersensitivity_rea	2.43958245
8	MP0001968_abnormal_touch/_nociception	2.29362876
9	MP0004145_abnormal_muscle_electrophysio	2.27405085
10	MP0002736_abnormal_nociception_after	2.23031311
11	MP0006292_abnormal_olfactory_placode	2.10261719
12	MP0002006_tumorigenesis	2.08256316
13	MP0002234_abnormal_pharynx_morphology	2.00791202
14	MP0000372_irregular_coat_pigmentation	1.98053264
15	MP0006072_abnormal_retinal_apoptosis	1.93999712
16	MP0008058_abnormal_DNA_repair	1.92844053
17	MP0005167_abnormal_blood-brain_barrier	1.89778753
18	MP0003806_abnormal_nucleotide_metabolis	1.75436795
19	MP0005000_abnormal_immune_tolerance	1.72811480
20	MP0001800_abnormal_humoral_immune	1.72681877
21	MP0005646_abnormal_pituitary_gland	1.71944604
22	MP0002876_abnormal_thyroid_physiology	1.63525704
23	MP0001919_abnormal_reproductive_system	1.62171553
24	MP0003724_increased_susceptibility_to	1.60461575
25	MP0008875_abnormal_xenobiotic_pharmacok	1.60401756
26	MP0009333_abnormal_splenocyte_physiolog	1.56999796
27	MP0003763_abnormal_thymus_physiology	1.55266755
28	MP0003436_decreased_susceptibility_to	1.46693868
29	MP0003646_muscle_fatigue	1.44482103
30	MP0005389_reproductive_system_phenotype	1.42886822
31	MP0000604_amyloidosis	1.42375383
32	MP0002452_abnormal_antigen_presenting	1.41815998
33	MP0009697_abnormal_copulation	1.41375259
34	MP0001853_heart_inflammation	1.38521483
35	MP0002723_abnormal_immune_serum	1.38479259
36	MP0002160_abnormal_reproductive_system	1.38076731
37	MP0002420_abnormal_adaptive_immunity	1.38020405
38	MP0001819_abnormal_immune_cell	1.35838438
39	MP0009785_altered_susceptibility_to	1.34827738
40	MP0009764_decreased_sensitivity_to	1.34670080
41	MP0005551_abnormal_eye_electrophysiolog	1.34336872
42	MP0002638_abnormal_pupillary_reflex	1.32523674
43	MP0005647_abnormal_sex_gland	1.31574312
44	MP0008872_abnormal_physiological_respon	1.29658365
45	MP0003866_abnormal_defecation	1.27404128
46	MP0003186_abnormal_redox_activity	1.23977542
47	MP0003718_maternal_effect	1.22850291
48	MP0002837_dystrophic_cardiac_calcinosis	1.21565995
49	MP0003195_calcinosis	1.17599639
50	MP0001905_abnormal_dopamine_level	1.15992517
51	MP0005075_abnormal_melanosome_morpholog	1.15300666
52	MP0005084_abnormal_gallbladder_morpholo	1.15264733
53	MP0002009_preneoplasia	1.14521853
54	MP0001661_extended_life_span	1.14014328
55	MP0000465_gastrointestinal_hemorrhage	1.12528009
56	MP0009379_abnormal_foot_pigmentation	1.10886545
57	MP0001790_abnormal_immune_system	1.10879676
58	MP0005387_immune_system_phenotype	1.10879676
59	MP0005253_abnormal_eye_physiology	1.10417365
60	MP0010155_abnormal_intestine_physiology	1.09831755
61	MP0005025_abnormal_response_to	1.06915804
62	MP0002419_abnormal_innate_immunity	1.06833860
63	MP0004043_abnormal_pH_regulation	1.05999936
64	MP0000685_abnormal_immune_system	1.04649629
65	MP0002102_abnormal_ear_morphology	0.97638563
66	MP0001845_abnormal_inflammatory_respons	0.96882380
67	MP0001984_abnormal_olfaction	0.96573173
68	MP0005645_abnormal_hypothalamus_physiol	0.96267778
69	MP0008775_abnormal_heart_ventricle	0.95480142
70	MP0009643_abnormal_urine_homeostasis	0.94203595
71	MP0001529_abnormal_vocalization	0.94056134
72	MP0000230_abnormal_systemic_arterial	0.93505739
73	MP0002405_respiratory_system_inflammati	0.93382712
74	MP0001440_abnormal_grooming_behavior	0.92385181
75	MP0003950_abnormal_plasma_membrane	0.92028776
76	MP0005464_abnormal_platelet_physiology	0.90315139
77	MP0000689_abnormal_spleen_morphology	0.89944177
78	MP0000716_abnormal_immune_system	0.89868097
79	MP0005636_abnormal_mineral_homeostasis	0.88310475
80	MP0000569_abnormal_digit_pigmentation	0.88268978
81	MP0001986_abnormal_taste_sensitivity	0.86666974
82	MP0005410_abnormal_fertilization	0.86593300
83	MP0003011_delayed_dark_adaptation	0.85139265
84	MP0005332_abnormal_amino_acid	0.84744043
85	MP0003786_premature_aging	0.84068675
86	MP0003567_abnormal_fetal_cardiomyocyte	0.82783865
87	MP0001486_abnormal_startle_reflex	0.82767093
88	MP0001502_abnormal_circadian_rhythm	0.82716572
89	MP0004885_abnormal_endolymph	0.81558683
90	MP0003638_abnormal_response/metabolism_	0.81339046
91	MP0004142_abnormal_muscle_tone	0.81291616
92	MP0002398_abnormal_bone_marrow	0.79083060
93	MP0009745_abnormal_behavioral_response	0.78740635
94	MP0001765_abnormal_ion_homeostasis	0.76804000
95	MP0002722_abnormal_immune_system	0.76776520
96	MP0003252_abnormal_bile_duct	0.76765357
97	MP0003075_altered_response_to	0.75616254
98	MP0000613_abnormal_salivary_gland	0.75295481
99	MP0006276_abnormal_autonomic_nervous	0.74442418
100	MP0002733_abnormal_thermal_nociception	0.73784437

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the prostate (HP:0008775)	4.91389861
2	Congenital, generalized hypertrichosis (HP:0004540)	4.89098923
3	Prostate neoplasm (HP:0100787)	4.82056600
4	Testicular atrophy (HP:0000029)	4.17455095
5	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.66199807
6	Acute necrotizing encephalopathy (HP:0006965)	3.51926609
7	Mitochondrial inheritance (HP:0001427)	3.43845609
8	Elevated erythrocyte sedimentation rate (HP:0003565)	3.40012040
9	Acute encephalopathy (HP:0006846)	3.31610748
10	Visual hallucinations (HP:0002367)	3.26686092
11	Congenital stationary night blindness (HP:0007642)	3.26459393
12	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.21105104
13	Progressive macrocephaly (HP:0004481)	3.20973855
14	Increased hepatocellular lipid droplets (HP:0006565)	3.19975399
15	Abnormal mitochondria in muscle tissue (HP:0008316)	3.14559481
16	Increased CSF lactate (HP:0002490)	3.13416533
17	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.11610558
18	Abnormal rod and cone electroretinograms (HP:0008323)	3.09801276
19	Pancreatic cysts (HP:0001737)	3.08536579
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.06736579
21	Abnormality of male internal genitalia (HP:0000022)	2.95679590
22	Hepatocellular necrosis (HP:0001404)	2.90381520
23	Increased cerebral lipofuscin (HP:0011813)	2.88454616
24	Type II lissencephaly (HP:0007260)	2.80212666
25	3-Methylglutaconic aciduria (HP:0003535)	2.80135756
26	Autoimmune thrombocytopenia (HP:0001973)	2.75669846
27	Lipid accumulation in hepatocytes (HP:0006561)	2.74768530
28	Type I transferrin isoform profile (HP:0003642)	2.73119068
29	Abnormality of the axillary hair (HP:0100134)	2.67558605
30	Abnormality of secondary sexual hair (HP:0009888)	2.67558605
31	Panhypogammaglobulinemia (HP:0003139)	2.64815385
32	Pancreatic fibrosis (HP:0100732)	2.63347623
33	Abnormal protein glycosylation (HP:0012346)	2.60894177
34	Abnormal glycosylation (HP:0012345)	2.60894177
35	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.60894177
36	Abnormal protein N-linked glycosylation (HP:0012347)	2.60894177
37	True hermaphroditism (HP:0010459)	2.59218065
38	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.58061320
39	Stomach cancer (HP:0012126)	2.54722686
40	Decreased central vision (HP:0007663)	2.54674157
41	Abolished electroretinogram (ERG) (HP:0000550)	2.54236089
42	Polydipsia (HP:0001959)	2.51947876
43	Abnormal drinking behavior (HP:0030082)	2.51947876
44	Reduced antithrombin III activity (HP:0001976)	2.51852937
45	Hepatic necrosis (HP:0002605)	2.47321291
46	IgG deficiency (HP:0004315)	2.46887010
47	Methylmalonic acidemia (HP:0002912)	2.46800241
48	Renal Fanconi syndrome (HP:0001994)	2.46777777
49	Aplastic anemia (HP:0001915)	2.46331721
50	Hypoproteinemia (HP:0003075)	2.44758454
51	Bile duct proliferation (HP:0001408)	2.41682689
52	Abnormal biliary tract physiology (HP:0012439)	2.41682689
53	Lactic acidosis (HP:0003128)	2.38292105
54	Increased corneal curvature (HP:0100692)	2.38002797
55	Keratoconus (HP:0000563)	2.38002797
56	Increased intramyocellular lipid droplets (HP:0012240)	2.28371547
57	Exertional dyspnea (HP:0002875)	2.23473363
58	Cerebral edema (HP:0002181)	2.20608397
59	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.17696134
60	Increased serum lactate (HP:0002151)	2.14537317
61	Autoimmune hemolytic anemia (HP:0001890)	2.11576441
62	Attenuation of retinal blood vessels (HP:0007843)	2.07279541
63	Pendular nystagmus (HP:0012043)	2.07052803
64	Stomatitis (HP:0010280)	2.05840033
65	Nephronophthisis (HP:0000090)	2.01807712
66	Abnormality of the renal cortex (HP:0011035)	2.00167416
67	Woolly hair (HP:0002224)	1.99836506
68	Optic disc pallor (HP:0000543)	1.99293281
69	Methylmalonic aciduria (HP:0012120)	1.99076022
70	Dry hair (HP:0011359)	1.96165173
71	Abnormality of alanine metabolism (HP:0010916)	1.95634820
72	Hyperalaninemia (HP:0003348)	1.95634820
73	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.95634820
74	Polyuria (HP:0000103)	1.94615965
75	Abnormality of midbrain morphology (HP:0002418)	1.94077095
76	Molar tooth sign on MRI (HP:0002419)	1.94077095
77	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.91739829
78	Hyperglycinemia (HP:0002154)	1.91147758
79	Pancytopenia (HP:0001876)	1.89299335
80	Renal cortical cysts (HP:0000803)	1.88794452
81	Asplenia (HP:0001746)	1.86073465
82	Abnormality of T cells (HP:0002843)	1.85709163
83	Abnormality of T cell physiology (HP:0011840)	1.85148519
84	Fair hair (HP:0002286)	1.84802362
85	Thyroiditis (HP:0100646)	1.83089298
86	Alveolar cell carcinoma (HP:0006519)	1.82529479
87	Dyschromatopsia (HP:0007641)	1.80982311
88	Entropion (HP:0000621)	1.80190599
89	Constricted visual fields (HP:0001133)	1.79699404
90	Opisthotonus (HP:0002179)	1.76246646
91	Type 2 muscle fiber atrophy (HP:0003554)	1.75933292
92	Hypothermia (HP:0002045)	1.75493753
93	Increased muscle lipid content (HP:0009058)	1.74966225
94	Abnormality of B cell number (HP:0010975)	1.73851271
95	Abnormality of cells of the erythroid lineage (HP:0012130)	1.72939347
96	Ureteral stenosis (HP:0000071)	1.72740516
97	Lethargy (HP:0001254)	1.72557348
98	Abnormal number of erythroid precursors (HP:0012131)	1.70603072
99	Exercise intolerance (HP:0003546)	1.70348260
100	Abnormality of serum amino acid levels (HP:0003112)	1.68750481

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.82025068
2	TXK	3.47307609
3	FRK	3.36098411
4	TLK1	2.91297888
5	BCKDK	2.69968603
6	NME2	2.66734680
7	TAOK3	2.65500190
8	TIE1	2.39840783
9	TEC	2.33242614
10	MAP4K1	2.26509897
11	GRK1	2.17233699
12	ADRBK2	2.05056075
13	MAPKAPK3	2.03499117
14	NUAK1	2.00541905
15	FES	1.98333471
16	ITK	1.84831473
17	IKBKB	1.76729172
18	GRK6	1.65096362
19	BMPR2	1.63455925
20	MAPKAPK5	1.62215768
21	WNK4	1.62210976
22	PHKG2	1.57046157
23	PHKG1	1.57046157
24	SYK	1.53152984
25	VRK2	1.52928658
26	BRD4	1.39161839
27	VRK1	1.36481358
28	BTK	1.26555943
29	PDK2	1.26244692
30	KDR	1.25905695
31	TRPM7	1.25215803
32	MKNK1	1.25015186
33	TESK2	1.16958453
34	ERBB3	1.15206878
35	KIT	1.15022424
36	LYN	1.11191573
37	EIF2AK3	1.11097322
38	MAP3K14	1.09897636
39	DAPK1	1.03992697
40	NEK1	1.02342806
41	PRKCQ	0.99973184
42	ZAP70	0.98395607
43	RPS6KA5	0.98192092
44	OXSR1	0.96276164
45	CAMKK2	0.96252473
46	DAPK2	0.93506002
47	PIK3CA	0.92509362
48	LCK	0.90874081
49	MATK	0.84481769
50	SCYL2	0.82565327
51	BLK	0.77506932
52	CDK19	0.77284932
53	ADRBK1	0.77048817
54	INSRR	0.76689451
55	MAP4K2	0.76647325
56	PIK3CG	0.74839855
57	PRKG2	0.74362338
58	CSF1R	0.72387461
59	WNK3	0.72017267
60	TNK2	0.71888547
61	BMPR1B	0.70009167
62	MAP3K12	0.67918104
63	IGF1R	0.66601522
64	ATR	0.63882101
65	PINK1	0.63811253
66	SRPK1	0.62606950
67	JAK3	0.59798365
68	MAPK7	0.59490699
69	ABL2	0.58737880
70	GRK5	0.56724760
71	MAP2K2	0.55951734
72	STK16	0.54493319
73	MAP3K13	0.53943023
74	MYLK	0.53508690
75	RPS6KA4	0.52061718
76	RIPK4	0.51510679
77	FLT3	0.49859945
78	ABL1	0.49345576
79	STK39	0.47779893
80	MAPK13	0.47179961
81	CSNK2A2	0.45756552
82	CAMK2D	0.45366401
83	PLK1	0.44942943
84	PRKCE	0.44335673
85	PLK2	0.44166480
86	PLK4	0.44096669
87	PLK3	0.43037804
88	RPS6KB2	0.42328783
89	HCK	0.42300023
90	MAP3K11	0.41990515
91	CSNK1G3	0.41920938
92	CHEK2	0.41050713
93	IKBKE	0.40394560
94	OBSCN	0.39949219
95	AURKA	0.39877368
96	TBK1	0.39839468
97	CSNK1A1	0.38839290
98	CLK1	0.38675944
99	AURKB	0.38220205
100	CSNK2A1	0.37807750

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	5.15525480
2	Allograft rejection_Homo sapiens_hsa05330	4.07867906
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.87285672
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.84217707
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.57529724
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.23563385
7	Ribosome_Homo sapiens_hsa03010	2.73496037
8	Proteasome_Homo sapiens_hsa03050	2.70709203
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.46433275
10	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.20812356
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.19883580
12	Antigen processing and presentation_Homo sapiens_hsa04612	2.05658124
13	Parkinsons disease_Homo sapiens_hsa05012	2.04203607
14	RNA polymerase_Homo sapiens_hsa03020	1.95784951
15	Phototransduction_Homo sapiens_hsa04744	1.89014076
16	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.88071272
17	Homologous recombination_Homo sapiens_hsa03440	1.87612419
18	Rheumatoid arthritis_Homo sapiens_hsa05323	1.69871594
19	Viral myocarditis_Homo sapiens_hsa05416	1.66879027
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.57472792
21	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.48090225
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.45747408
23	Protein export_Homo sapiens_hsa03060	1.45138665
24	Leishmaniasis_Homo sapiens_hsa05140	1.41390239
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.38057172
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.36877624
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.29609011
28	Basal transcription factors_Homo sapiens_hsa03022	1.24627889
29	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.22799257
30	Alzheimers disease_Homo sapiens_hsa05010	1.21873059
31	Mismatch repair_Homo sapiens_hsa03430	1.21780704
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.18009015
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.17848160
34	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.17226174
35	Huntingtons disease_Homo sapiens_hsa05016	1.13491939
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.11851853
37	RNA degradation_Homo sapiens_hsa03018	1.09861396
38	Nucleotide excision repair_Homo sapiens_hsa03420	1.07545619
39	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.98670678
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95928521
41	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.94151477
42	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.93908752
43	Ether lipid metabolism_Homo sapiens_hsa00565	0.89388492
44	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.88458526
45	Purine metabolism_Homo sapiens_hsa00230	0.88026855
46	Spliceosome_Homo sapiens_hsa03040	0.85630379
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.83878918
48	Propanoate metabolism_Homo sapiens_hsa00640	0.82907180
49	Sulfur relay system_Homo sapiens_hsa04122	0.76201631
50	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.74920630
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.74057360
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71863715
53	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.69590091
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69530378
55	Herpes simplex infection_Homo sapiens_hsa05168	0.67030590
56	Olfactory transduction_Homo sapiens_hsa04740	0.65288121
57	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.61744277
58	Selenocompound metabolism_Homo sapiens_hsa00450	0.60935118
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56543868
60	Base excision repair_Homo sapiens_hsa03410	0.54525405
61	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.52997791
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52894627
63	Salivary secretion_Homo sapiens_hsa04970	0.51316946
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.49898243
65	One carbon pool by folate_Homo sapiens_hsa00670	0.45557111
66	Tryptophan metabolism_Homo sapiens_hsa00380	0.44806141
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44391298
68	RNA transport_Homo sapiens_hsa03013	0.43163526
69	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.42638406
70	Peroxisome_Homo sapiens_hsa04146	0.40350636
71	Retinol metabolism_Homo sapiens_hsa00830	0.39308394
72	Butanoate metabolism_Homo sapiens_hsa00650	0.38076506
73	Metabolic pathways_Homo sapiens_hsa01100	0.38007126
74	DNA replication_Homo sapiens_hsa03030	0.37656509
75	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.36641710
76	Sulfur metabolism_Homo sapiens_hsa00920	0.35848433
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33322089
78	Non-homologous end-joining_Homo sapiens_hsa03450	0.32790832
79	Caffeine metabolism_Homo sapiens_hsa00232	0.31664381
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.31227052
81	Tuberculosis_Homo sapiens_hsa05152	0.30086665
82	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.28051082
83	Phagosome_Homo sapiens_hsa04145	0.27954101
84	Glutathione metabolism_Homo sapiens_hsa00480	0.26545735
85	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.26355254
86	Toxoplasmosis_Homo sapiens_hsa05145	0.26096532
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.25589443
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.24878481
89	Taste transduction_Homo sapiens_hsa04742	0.24818246
90	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.23930077
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.23507555
92	Influenza A_Homo sapiens_hsa05164	0.22055622
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.20011712
94	Fatty acid elongation_Homo sapiens_hsa00062	0.19675712
95	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.17482070
96	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.17358300
97	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.17031469
98	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.16707138
99	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.16067975
100	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.16034226

RPL32P28

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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