ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	9.00622643
2	viral transcription (GO:0019083)	8.83868317
3	translational termination (GO:0006415)	8.45438534
4	ribosomal small subunit biogenesis (GO:0042274)	7.44455759
5	translational elongation (GO:0006414)	7.23662643
6	maturation of SSU-rRNA (GO:0030490)	7.23544318
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.12255769
8	cotranslational protein targeting to membrane (GO:0006613)	7.05355951
9	protein targeting to ER (GO:0045047)	7.03796678
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.73905469
11	protein localization to endoplasmic reticulum (GO:0070972)	6.67902211
12	cellular protein complex disassembly (GO:0043624)	6.45967979
13	viral life cycle (GO:0019058)	6.33045195
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.16835192
15	ATP synthesis coupled proton transport (GO:0015986)	6.16835192
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.15709217
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.60040753
18	protein complex disassembly (GO:0043241)	5.43844100
19	protein neddylation (GO:0045116)	5.43522883
20	translational initiation (GO:0006413)	5.42396460
21	macromolecular complex disassembly (GO:0032984)	5.12869313
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.81776704
23	protein targeting to membrane (GO:0006612)	4.77298630
24	behavioral response to nicotine (GO:0035095)	4.67199888
25	chaperone-mediated protein transport (GO:0072321)	4.47984235
26	translation (GO:0006412)	4.37608734
27	ribosomal large subunit biogenesis (GO:0042273)	4.27419042
28	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.24042770
29	respiratory electron transport chain (GO:0022904)	4.20827725
30	electron transport chain (GO:0022900)	4.17526252
31	mRNA catabolic process (GO:0006402)	4.01715683
32	protein complex biogenesis (GO:0070271)	3.88911051
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.81184564
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.81184564
35	NADH dehydrogenase complex assembly (GO:0010257)	3.81184564
36	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.79270278
37	water-soluble vitamin biosynthetic process (GO:0042364)	3.71427637
38	RNA catabolic process (GO:0006401)	3.63573578
39	DNA deamination (GO:0045006)	3.61939912
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.53821557
41	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.53114692
42	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.53114692
43	nonmotile primary cilium assembly (GO:0035058)	3.43254378
44	ribonucleoprotein complex biogenesis (GO:0022613)	3.41217949
45	cellular component biogenesis (GO:0044085)	3.40706076
46	endoderm formation (GO:0001706)	3.35882680
47	ATP biosynthetic process (GO:0006754)	3.35819238
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.27043969
49	hydrogen ion transmembrane transport (GO:1902600)	3.26379139
50	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.25322498
51	establishment of protein localization to membrane (GO:0090150)	3.21964777
52	cardiovascular system development (GO:0072358)	3.19253681
53	protein targeting (GO:0006605)	3.08993378
54	synaptic transmission, cholinergic (GO:0007271)	3.02842216
55	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.96804319
56	head development (GO:0060322)	2.96609970
57	proton transport (GO:0015992)	2.95545931
58	GTP biosynthetic process (GO:0006183)	2.92082823
59	positive regulation of respiratory burst (GO:0060267)	2.91093310
60	myoblast migration (GO:0051451)	2.90471206
61	hydrogen transport (GO:0006818)	2.89109103
62	rRNA processing (GO:0006364)	2.88336934
63	establishment of protein localization to organelle (GO:0072594)	2.87746672
64	rRNA metabolic process (GO:0016072)	2.87140886
65	sequestering of actin monomers (GO:0042989)	2.86896320
66	epithelial cilium movement (GO:0003351)	2.83667765
67	cell proliferation in forebrain (GO:0021846)	2.83629853
68	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.81276302
69	positive regulation of T cell apoptotic process (GO:0070234)	2.81076927
70	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.81014586
71	protein polyglutamylation (GO:0018095)	2.76358457
72	platelet dense granule organization (GO:0060155)	2.75850156
73	intracellular protein transmembrane import (GO:0044743)	2.75473557
74	somite development (GO:0061053)	2.72212875
75	regulation of cilium movement (GO:0003352)	2.71264499
76	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.68955364
77	axoneme assembly (GO:0035082)	2.62736276
78	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.60365909
79	protein localization to membrane (GO:0072657)	2.59406851
80	protein-cofactor linkage (GO:0018065)	2.58891405
81	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.58243789
82	hypothalamus development (GO:0021854)	2.57493094
83	pseudouridine synthesis (GO:0001522)	2.55588333
84	UTP biosynthetic process (GO:0006228)	2.53779493
85	nucleoside triphosphate biosynthetic process (GO:0009142)	2.51489577
86	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.50620601
87	spinal cord association neuron differentiation (GO:0021527)	2.46420025
88	ncRNA 3-end processing (GO:0043628)	2.43911235
89	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.43679266
90	parturition (GO:0007567)	2.43528398
91	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.40183679
92	substrate-independent telencephalic tangential migration (GO:0021826)	2.40183679
93	cytochrome complex assembly (GO:0017004)	2.39703108
94	negative regulation of telomere maintenance (GO:0032205)	2.38863380
95	tRNA processing (GO:0008033)	2.37459902
96	regulation of glycogen (starch) synthase activity (GO:2000465)	2.35745974
97	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.35249695
98	UTP metabolic process (GO:0046051)	2.34636531
99	cilium movement (GO:0003341)	2.31991159
100	respiratory chain complex IV assembly (GO:0008535)	2.30483650

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.83437420
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.05962678
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.95182427
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.59988529
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.53349589
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.77117421
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.61967196
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.55122766
9	VDR_22108803_ChIP-Seq_LS180_Human	2.37770563
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.30105439
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.12744209
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.11229215
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.00353690
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.73622855
15	MYC_18940864_ChIP-ChIP_HL60_Human	1.71712907
16	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.67592330
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.65703070
18	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64737891
19	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.63171320
20	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.62649488
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61744778
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.60746285
23	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.59578096
24	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.58853767
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.51126935
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.50863964
27	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.45408732
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.43305787
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.42345699
30	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.41955541
31	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.40913323
32	REST_21632747_ChIP-Seq_MESCs_Mouse	1.39113134
33	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.35972728
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.34594780
35	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.33587971
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33242125
37	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31384779
38	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28723643
39	ELK1_19687146_ChIP-ChIP_HELA_Human	1.28142317
40	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.27782707
41	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.26940781
42	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.25312180
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25248821
44	TTF2_22483619_ChIP-Seq_HELA_Human	1.24610482
45	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.24008664
46	NANOG_20526341_ChIP-Seq_ESCs_Human	1.23514093
47	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.22698175
48	XRN2_22483619_ChIP-Seq_HELA_Human	1.22604741
49	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22380219
50	FUS_26573619_Chip-Seq_HEK293_Human	1.22265039
51	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.21937814
52	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.20870474
53	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.20686173
54	NCOR_22424771_ChIP-Seq_293T_Human	1.19200929
55	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.18544345
56	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.18427432
57	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.17591655
58	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.15552147
59	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.14815305
60	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.14193435
61	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.13560412
62	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08760295
63	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.08707075
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.07341844
65	EWS_26573619_Chip-Seq_HEK293_Human	1.05394162
66	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.04428624
67	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04187656
68	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.03034329
69	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.02890126
70	RNF2_27304074_Chip-Seq_NSC_Mouse	1.00861054
71	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00196881
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00196881
73	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.99656870
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99082242
75	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.98848244
76	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.98543919
77	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.98097036
78	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95377325
79	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.95152544
80	CTCF_27219007_Chip-Seq_Bcells_Human	0.95114631
81	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.94913191
82	CTCF_20526341_ChIP-Seq_ESCs_Human	0.94535786
83	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.94459129
84	ERA_21632823_ChIP-Seq_H3396_Human	0.93427059
85	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.93396943
86	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.93151875
87	TAF2_19829295_ChIP-Seq_ESCs_Human	0.92943658
88	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.92134933
89	MYC_19829295_ChIP-Seq_ESCs_Human	0.91126241
90	P53_21459846_ChIP-Seq_SAOS-2_Human	0.88615426
91	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.87387313
92	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.87024245
93	GBX2_23144817_ChIP-Seq_PC3_Human	0.86871620
94	BCL6_27268052_Chip-Seq_Bcells_Human	0.84519895
95	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.84342808
96	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.83750335
97	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.83185285
98	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.82689623
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.82408248
100	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.81906871

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.79122172
2	MP0003787_abnormal_imprinting	4.13559066
3	MP0006292_abnormal_olfactory_placode	3.52943200
4	MP0008877_abnormal_DNA_methylation	3.25569751
5	MP0003123_paternal_imprinting	2.72669327
6	MP0003121_genomic_imprinting	2.48537353
7	MP0002163_abnormal_gland_morphology	2.28858696
8	MP0004885_abnormal_endolymph	2.22937088
9	MP0004142_abnormal_muscle_tone	2.21554395
10	MP0004145_abnormal_muscle_electrophysio	2.20398106
11	MP0003122_maternal_imprinting	2.20330339
12	MP0006276_abnormal_autonomic_nervous	2.16919369
13	MP0008789_abnormal_olfactory_epithelium	2.04872226
14	MP0003646_muscle_fatigue	1.94646089
15	MP0006072_abnormal_retinal_apoptosis	1.94455856
16	MP0002638_abnormal_pupillary_reflex	1.84030604
17	MP0002653_abnormal_ependyma_morphology	1.81360450
18	MP0005551_abnormal_eye_electrophysiolog	1.75108786
19	MP0001968_abnormal_touch/_nociception	1.75084164
20	MP0005377_hearing/vestibular/ear_phenot	1.73317675
21	MP0003878_abnormal_ear_physiology	1.73317675
22	MP0002160_abnormal_reproductive_system	1.71532858
23	MP0005084_abnormal_gallbladder_morpholo	1.70946917
24	MP0000049_abnormal_middle_ear	1.70207519
25	MP0004742_abnormal_vestibular_system	1.69764127
26	MP0002837_dystrophic_cardiac_calcinosis	1.66442587
27	MP0008875_abnormal_xenobiotic_pharmacok	1.58153608
28	MP0004147_increased_porphyrin_level	1.57553273
29	MP0005394_taste/olfaction_phenotype	1.55409977
30	MP0005499_abnormal_olfactory_system	1.55409977
31	MP0001485_abnormal_pinna_reflex	1.51035027
32	MP0005389_reproductive_system_phenotype	1.50983308
33	MP0002272_abnormal_nervous_system	1.49269630
34	MP0005174_abnormal_tail_pigmentation	1.49224124
35	MP0002102_abnormal_ear_morphology	1.48436889
36	MP0002736_abnormal_nociception_after	1.47998143
37	MP0004133_heterotaxia	1.45914521
38	MP0001293_anophthalmia	1.44099999
39	MP0001440_abnormal_grooming_behavior	1.39209164
40	MP0002557_abnormal_social/conspecific_i	1.35286533
41	MP0001905_abnormal_dopamine_level	1.34590186
42	MP0005646_abnormal_pituitary_gland	1.32621359
43	MP0001188_hyperpigmentation	1.31714179
44	MP0001970_abnormal_pain_threshold	1.29626583
45	MP0002938_white_spotting	1.28724767
46	MP0002095_abnormal_skin_pigmentation	1.26050980
47	MP0000778_abnormal_nervous_system	1.26024552
48	MP0002733_abnormal_thermal_nociception	1.25816961
49	MP0002184_abnormal_innervation	1.24536624
50	MP0001919_abnormal_reproductive_system	1.20825989
51	MP0005645_abnormal_hypothalamus_physiol	1.20662337
52	MP0003011_delayed_dark_adaptation	1.20513876
53	MP0009046_muscle_twitch	1.19161816
54	MP0005195_abnormal_posterior_eye	1.16459887
55	MP0008872_abnormal_physiological_respon	1.16385458
56	MP0009745_abnormal_behavioral_response	1.14441089
57	MP0005379_endocrine/exocrine_gland_phen	1.14338165
58	MP0003938_abnormal_ear_development	1.13634570
59	MP0000026_abnormal_inner_ear	1.12810027
60	MP0002752_abnormal_somatic_nervous	1.12610050
61	MP0000631_abnormal_neuroendocrine_gland	1.11032671
62	MP0003880_abnormal_central_pattern	1.09887221
63	MP0003136_yellow_coat_color	1.07584225
64	MP0009053_abnormal_anal_canal	1.04873713
65	MP0001986_abnormal_taste_sensitivity	1.04424494
66	MP0003879_abnormal_hair_cell	1.03699232
67	MP0002928_abnormal_bile_duct	1.00602733
68	MP0000955_abnormal_spinal_cord	0.99649940
69	MP0001486_abnormal_startle_reflex	0.96914666
70	MP0001984_abnormal_olfaction	0.96807767
71	MP0005075_abnormal_melanosome_morpholog	0.96776310
72	MP0002277_abnormal_respiratory_mucosa	0.96555386
73	MP0005253_abnormal_eye_physiology	0.94970511
74	MP0005671_abnormal_response_to	0.94354289
75	MP0002572_abnormal_emotion/affect_behav	0.93214247
76	MP0001963_abnormal_hearing_physiology	0.92546897
77	MP0002876_abnormal_thyroid_physiology	0.91803029
78	MP0002734_abnormal_mechanical_nocicepti	0.90442183
79	MP0002735_abnormal_chemical_nociception	0.89307162
80	MP0003186_abnormal_redox_activity	0.82892045
81	MP0008058_abnormal_DNA_repair	0.82480566
82	MP0003718_maternal_effect	0.81003651
83	MP0002234_abnormal_pharynx_morphology	0.80521159
84	MP0003635_abnormal_synaptic_transmissio	0.80148797
85	MP0002063_abnormal_learning/memory/cond	0.79143519
86	MP0001324_abnormal_eye_pigmentation	0.79131622
87	MP0001286_abnormal_eye_development	0.78894983
88	MP0002210_abnormal_sex_determination	0.77524579
89	MP0002067_abnormal_sensory_capabilities	0.77093245
90	MP0005423_abnormal_somatic_nervous	0.75605988
91	MP0003567_abnormal_fetal_cardiomyocyte	0.73884932
92	MP0003638_abnormal_response/metabolism_	0.72082274
93	MP0002882_abnormal_neuron_morphology	0.68534646
94	MP0000569_abnormal_digit_pigmentation	0.68148441
95	MP0009250_abnormal_appendicular_skeleto	0.67415130
96	MP0002064_seizures	0.66935390
97	MP0002138_abnormal_hepatobiliary_system	0.66547879
98	MP0000427_abnormal_hair_cycle	0.65723382
99	MP0002229_neurodegeneration	0.65145356
100	MP0003942_abnormal_urinary_system	0.64819618

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.01724792
2	Abnormality of cells of the erythroid lineage (HP:0012130)	5.36624855
3	Acute necrotizing encephalopathy (HP:0006965)	4.67855058
4	Abnormal number of erythroid precursors (HP:0012131)	4.15477220
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.07994961
6	Acute encephalopathy (HP:0006846)	4.05390058
7	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.98816645
8	Macrocytic anemia (HP:0001972)	3.91764561
9	Progressive macrocephaly (HP:0004481)	3.78161106
10	Mitochondrial inheritance (HP:0001427)	3.73375490
11	Pancreatic fibrosis (HP:0100732)	3.72675501
12	Congenital stationary night blindness (HP:0007642)	3.49634923
13	Abnormal rod and cone electroretinograms (HP:0008323)	3.42387147
14	Pancreatic cysts (HP:0001737)	3.32426825
15	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.31393420
16	Increased CSF lactate (HP:0002490)	3.23461008
17	Abnormality of midbrain morphology (HP:0002418)	3.19778667
18	Molar tooth sign on MRI (HP:0002419)	3.19778667
19	True hermaphroditism (HP:0010459)	3.03775312
20	Septo-optic dysplasia (HP:0100842)	3.03605186
21	Pallor (HP:0000980)	3.03275430
22	Pendular nystagmus (HP:0012043)	3.02717456
23	Cerebral edema (HP:0002181)	2.87919995
24	Type 2 muscle fiber atrophy (HP:0003554)	2.85711720
25	Stenosis of the external auditory canal (HP:0000402)	2.84761025
26	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.82029482
27	Nephronophthisis (HP:0000090)	2.77746572
28	Absent thumb (HP:0009777)	2.76509414
29	Asplenia (HP:0001746)	2.72152550
30	Optic disc pallor (HP:0000543)	2.63585719
31	Abnormality of the renal cortex (HP:0011035)	2.54427773
32	Increased hepatocellular lipid droplets (HP:0006565)	2.51085277
33	Renal Fanconi syndrome (HP:0001994)	2.48539265
34	Supernumerary spleens (HP:0009799)	2.42748176
35	Polydipsia (HP:0001959)	2.42725253
36	Abnormal drinking behavior (HP:0030082)	2.42725253
37	Anencephaly (HP:0002323)	2.40161329
38	Tubular atrophy (HP:0000092)	2.39349955
39	Medial flaring of the eyebrow (HP:0010747)	2.38385853
40	Myokymia (HP:0002411)	2.38161460
41	Hepatocellular necrosis (HP:0001404)	2.37420197
42	Abnormality of the renal medulla (HP:0100957)	2.37306233
43	Colon cancer (HP:0003003)	2.35510256
44	Sclerocornea (HP:0000647)	2.31041364
45	Lipid accumulation in hepatocytes (HP:0006561)	2.30707172
46	Muscle fiber atrophy (HP:0100295)	2.28563043
47	Cystic liver disease (HP:0006706)	2.25766168
48	Congenital, generalized hypertrichosis (HP:0004540)	2.23712239
49	Depressed nasal ridge (HP:0000457)	2.21822521
50	Polyphagia (HP:0002591)	2.15799349
51	Polyuria (HP:0000103)	2.13198271
52	Renal cortical cysts (HP:0000803)	2.12680349
53	Abolished electroretinogram (ERG) (HP:0000550)	2.11738180
54	Increased serum lactate (HP:0002151)	2.11248440
55	Agitation (HP:0000713)	2.06530063
56	Abnormality of magnesium homeostasis (HP:0004921)	2.05151109
57	Hepatic necrosis (HP:0002605)	2.05074871
58	Maternal diabetes (HP:0009800)	2.04274025
59	3-Methylglutaconic aciduria (HP:0003535)	2.03302341
60	Optic nerve hypoplasia (HP:0000609)	2.03214316
61	Abnormal hemoglobin (HP:0011902)	2.02517000
62	Increased intramyocellular lipid droplets (HP:0012240)	2.02378380
63	Leukodystrophy (HP:0002415)	1.99771488
64	Hypomagnesemia (HP:0002917)	1.99127494
65	Abnormality of renal resorption (HP:0011038)	1.98314577
66	Lethargy (HP:0001254)	1.96200834
67	Chorioretinal atrophy (HP:0000533)	1.95529156
68	Rib fusion (HP:0000902)	1.94223034
69	Chronic hepatic failure (HP:0100626)	1.92372035
70	Increased corneal curvature (HP:0100692)	1.92153084
71	Keratoconus (HP:0000563)	1.92153084
72	Hyperglycinemia (HP:0002154)	1.90887079
73	Male pseudohermaphroditism (HP:0000037)	1.90511571
74	Hypoplasia of the radius (HP:0002984)	1.89997064
75	Abnormality of the labia minora (HP:0012880)	1.88109752
76	Absent septum pellucidum (HP:0001331)	1.87671476
77	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.85903668
78	Adrenal hypoplasia (HP:0000835)	1.85799402
79	Respiratory failure (HP:0002878)	1.84759355
80	Lactic acidosis (HP:0003128)	1.84719743
81	Oligomenorrhea (HP:0000876)	1.84668639
82	Anomalous pulmonary venous return (HP:0010772)	1.82999919
83	Methylmalonic aciduria (HP:0012120)	1.79824579
84	Type II lissencephaly (HP:0007260)	1.78544689
85	Exercise intolerance (HP:0003546)	1.78351234
86	Hypoplasia of the ulna (HP:0003022)	1.77887517
87	Gait imbalance (HP:0002141)	1.74541239
88	Triphalangeal thumb (HP:0001199)	1.73508366
89	Congenital hepatic fibrosis (HP:0002612)	1.72811748
90	Decreased central vision (HP:0007663)	1.72026601
91	Forearm undergrowth (HP:0009821)	1.71851762
92	Growth hormone deficiency (HP:0000824)	1.69772912
93	Abnormal urine output (HP:0012590)	1.69526146
94	Anterior segment dysgenesis (HP:0007700)	1.69027047
95	Bony spicule pigmentary retinopathy (HP:0007737)	1.68246990
96	Abnormality of cochlea (HP:0000375)	1.67912355
97	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.66081189
98	Abnormality of reticulocytes (HP:0004312)	1.65734887
99	Anophthalmia (HP:0000528)	1.65675911
100	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.64500677

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	4.07758748
2	BCKDK	2.86925024
3	TXK	2.70803691
4	WNK4	2.60755636
5	VRK2	2.47314946
6	TLK1	2.31455237
7	EPHB2	2.31240076
8	ADRBK2	2.29764256
9	TESK2	2.26838165
10	DYRK2	2.18492720
11	GRK1	2.08548606
12	ZAK	2.00725754
13	MAP4K2	1.83119510
14	MAP3K12	1.81780509
15	LIMK1	1.80823558
16	CDC7	1.79778953
17	PASK	1.76679873
18	KDR	1.67649288
19	NUAK1	1.64320320
20	BUB1	1.45257419
21	CAMKK1	1.38049927
22	FRK	1.37839587
23	TIE1	1.34160433
24	NME1	1.30622637
25	PRKCG	1.27373237
26	MAPKAPK5	1.24910692
27	CAMKK2	1.23562302
28	STK39	1.23056388
29	MAP3K11	1.19840467
30	NTRK2	1.12901098
31	TAOK3	1.11052868
32	RPS6KA5	1.10964768
33	TEC	1.08363726
34	CDK19	1.08272780
35	VRK1	1.08159169
36	PIK3CA	1.07701530
37	PRKCQ	1.05422065
38	ITK	1.04475238
39	CAMK1	1.01865872
40	CASK	0.98421955
41	BMPR1B	0.98104753
42	MAP4K1	0.95577445
43	ADRBK1	0.94145620
44	LRRK2	0.93156197
45	MARK1	0.92924924
46	WNK3	0.92626529
47	PAK3	0.92267377
48	MAP2K2	0.90352293
49	BTK	0.88718889
50	SGK223	0.88079515
51	SGK494	0.88079515
52	TAF1	0.87753964
53	PINK1	0.87015655
54	DAPK3	0.86351821
55	PDK2	0.85924563
56	OXSR1	0.84902934
57	IKBKB	0.83707184
58	INSRR	0.79533008
59	DYRK1B	0.77910015
60	PHKG2	0.77604607
61	PHKG1	0.77604607
62	BRAF	0.73153917
63	PRKACA	0.69399818
64	MAPK13	0.68310704
65	AURKB	0.68081297
66	GRK6	0.68039494
67	CSNK2A2	0.67995420
68	MAP2K7	0.66701213
69	RPS6KA6	0.65612055
70	MKNK1	0.64979751
71	SYK	0.63371826
72	TNK2	0.62660753
73	SGK1	0.61920913
74	KIT	0.61385622
75	MINK1	0.61315839
76	AURKA	0.60263294
77	PLK4	0.60043355
78	TNIK	0.59422751
79	MST4	0.58328931
80	GRK7	0.57540369
81	MAP3K9	0.55757359
82	PRKCD	0.55328797
83	CDK3	0.54731615
84	OBSCN	0.50729821
85	IKBKE	0.45946542
86	CSNK1G2	0.45390318
87	MKNK2	0.44732595
88	CSNK1E	0.43832598
89	PRKCA	0.43609317
90	PRKCH	0.43443746
91	RPS6KB2	0.43336890
92	TYRO3	0.43111122
93	NME2	0.42332838
94	RPS6KL1	0.42151731
95	RPS6KC1	0.42151731
96	LYN	0.40439229
97	PRKCI	0.39429191
98	CHEK2	0.39182323
99	SGK2	0.39118820
100	PRKCZ	0.38790731

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.83203477
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.68972353
3	Parkinsons disease_Homo sapiens_hsa05012	4.01276064
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.83778391
5	Alzheimers disease_Homo sapiens_hsa05010	2.76406478
6	Huntingtons disease_Homo sapiens_hsa05016	2.71623613
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.60251088
8	Proteasome_Homo sapiens_hsa03050	2.53319319
9	RNA polymerase_Homo sapiens_hsa03020	2.04928560
10	Phototransduction_Homo sapiens_hsa04744	1.98944323
11	Protein export_Homo sapiens_hsa03060	1.83009501
12	Homologous recombination_Homo sapiens_hsa03440	1.77321701
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.75501787
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.57226805
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.57106440
16	Mismatch repair_Homo sapiens_hsa03430	1.56855925
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.53805556
18	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.50560123
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.44494820
20	Caffeine metabolism_Homo sapiens_hsa00232	1.43946527
21	RNA degradation_Homo sapiens_hsa03018	1.31388499
22	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.31173618
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.29491723
24	Basal transcription factors_Homo sapiens_hsa03022	1.29489243
25	DNA replication_Homo sapiens_hsa03030	1.27448595
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.26348423
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.24166161
28	Nicotine addiction_Homo sapiens_hsa05033	1.23295137
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.19433396
30	Primary immunodeficiency_Homo sapiens_hsa05340	1.19294547
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.19272347
32	Base excision repair_Homo sapiens_hsa03410	1.10894252
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.09145112
34	One carbon pool by folate_Homo sapiens_hsa00670	1.03081800
35	Butanoate metabolism_Homo sapiens_hsa00650	1.00476155
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00289025
37	Peroxisome_Homo sapiens_hsa04146	0.95373054
38	Fat digestion and absorption_Homo sapiens_hsa04975	0.94125417
39	Sulfur relay system_Homo sapiens_hsa04122	0.93270590
40	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91911816
41	Retinol metabolism_Homo sapiens_hsa00830	0.87399726
42	Olfactory transduction_Homo sapiens_hsa04740	0.85789767
43	Spliceosome_Homo sapiens_hsa03040	0.84027539
44	Asthma_Homo sapiens_hsa05310	0.81682790
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.81232196
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80775300
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.77945235
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74383734
49	Morphine addiction_Homo sapiens_hsa05032	0.73013893
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.72161421
51	Folate biosynthesis_Homo sapiens_hsa00790	0.71798058
52	Allograft rejection_Homo sapiens_hsa05330	0.70220381
53	Basal cell carcinoma_Homo sapiens_hsa05217	0.69700756
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.69611033
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.69109670
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.66664920
57	Purine metabolism_Homo sapiens_hsa00230	0.65804422
58	Metabolic pathways_Homo sapiens_hsa01100	0.64286809
59	Propanoate metabolism_Homo sapiens_hsa00640	0.63947361
60	RNA transport_Homo sapiens_hsa03013	0.63609104
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63106678
62	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.62300039
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.59919939
64	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.59677337
65	Nitrogen metabolism_Homo sapiens_hsa00910	0.58410142
66	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.56785270
67	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.56223825
68	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.55977170
69	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53338122
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51515364
71	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.51474907
72	Graft-versus-host disease_Homo sapiens_hsa05332	0.50067910
73	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.49616799
74	Taste transduction_Homo sapiens_hsa04742	0.49596871
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49233523
76	Steroid biosynthesis_Homo sapiens_hsa00100	0.47536165
77	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.47040743
78	Antigen processing and presentation_Homo sapiens_hsa04612	0.45838061
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45786131
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44601232
81	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.39073279
82	Insulin secretion_Homo sapiens_hsa04911	0.38605104
83	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.38519107
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38448039
85	Serotonergic synapse_Homo sapiens_hsa04726	0.37915903
86	Tyrosine metabolism_Homo sapiens_hsa00350	0.37012845
87	Type I diabetes mellitus_Homo sapiens_hsa04940	0.33403115
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29630840
89	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.28212640
90	Salivary secretion_Homo sapiens_hsa04970	0.27631167
91	Axon guidance_Homo sapiens_hsa04360	0.27557864
92	Glutamatergic synapse_Homo sapiens_hsa04724	0.26900190
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.25860766
94	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.25438383
95	GABAergic synapse_Homo sapiens_hsa04727	0.25086983
96	Selenocompound metabolism_Homo sapiens_hsa00450	0.24942229
97	Circadian entrainment_Homo sapiens_hsa04713	0.21923744
98	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.21363871
99	Rheumatoid arthritis_Homo sapiens_hsa05323	0.20359348
100	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.19342584

RPL32P31

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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