ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	8.68551910
2	viral transcription (GO:0019083)	7.64803118
3	behavioral response to nicotine (GO:0035095)	7.42997806
4	translational termination (GO:0006415)	7.27156038
5	ribosomal small subunit biogenesis (GO:0042274)	7.18256434
6	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	6.89952905
7	axoneme assembly (GO:0035082)	6.27870648
8	translational elongation (GO:0006414)	5.90546242
9	pyrimidine nucleobase catabolic process (GO:0006208)	5.90122115
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.88769117
11	protein targeting to ER (GO:0045047)	5.86292959
12	cotranslational protein targeting to membrane (GO:0006613)	5.79067742
13	nonmotile primary cilium assembly (GO:0035058)	5.69356882
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.60140764
15	cellular protein complex disassembly (GO:0043624)	5.59060528
16	cellular response to dexamethasone stimulus (GO:0071549)	5.57300787
17	protein localization to endoplasmic reticulum (GO:0070972)	5.51554562
18	negative regulation of T cell differentiation in thymus (GO:0033085)	5.40868509
19	viral life cycle (GO:0019058)	5.32156520
20	maturation of SSU-rRNA (GO:0030490)	5.22942849
21	positive regulation of muscle cell apoptotic process (GO:0010661)	5.22617068
22	response to dexamethasone (GO:0071548)	5.20002387
23	embryonic body morphogenesis (GO:0010172)	5.14736940
24	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.11595738
25	establishment of tissue polarity (GO:0007164)	5.02816052
26	establishment of planar polarity (GO:0001736)	5.02816052
27	protein complex disassembly (GO:0043241)	4.77015473
28	nucleobase catabolic process (GO:0046113)	4.74526673
29	body morphogenesis (GO:0010171)	4.61106213
30	macromolecular complex disassembly (GO:0032984)	4.42003198
31	regulation of antigen processing and presentation (GO:0002577)	4.41571744
32	translational initiation (GO:0006413)	4.38143344
33	ribosomal large subunit biogenesis (GO:0042273)	4.32058866
34	snRNA transcription (GO:0009301)	4.27510644
35	glomerular filtration (GO:0003094)	4.14337697
36	cilium movement (GO:0003341)	4.12747105
37	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	4.10960980
38	valine metabolic process (GO:0006573)	4.05125967
39	positive regulation of organelle assembly (GO:1902117)	4.02961537
40	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.00282124
41	synaptic transmission, cholinergic (GO:0007271)	4.00249706
42	protein targeting to membrane (GO:0006612)	3.94323267
43	negative regulation of defense response to virus (GO:0050687)	3.89043870
44	negative regulation of macrophage differentiation (GO:0045650)	3.85584569
45	regulation of interleukin-12 biosynthetic process (GO:0045075)	3.84083472
46	regulation of isotype switching to IgG isotypes (GO:0048302)	3.81400139
47	lysosome localization (GO:0032418)	3.75198498
48	negative regulation of cell cycle arrest (GO:0071157)	3.74814893
49	mast cell degranulation (GO:0043303)	3.61845145
50	mast cell activation involved in immune response (GO:0002279)	3.61845145
51	renal filtration (GO:0097205)	3.60139457
52	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.56272455
53	cellular extravasation (GO:0045123)	3.53028854
54	translation (GO:0006412)	3.50170012
55	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.47739445
56	ATP synthesis coupled proton transport (GO:0015986)	3.47739445
57	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.47619691
58	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.47619691
59	NADH dehydrogenase complex assembly (GO:0010257)	3.47619691
60	histone H4-K12 acetylation (GO:0043983)	3.43706298
61	regulation of smooth muscle cell apoptotic process (GO:0034391)	3.43254658
62	positive regulation of viral genome replication (GO:0045070)	3.41821027
63	positive regulation of T cell apoptotic process (GO:0070234)	3.31851133
64	neurofilament cytoskeleton organization (GO:0060052)	3.31621542
65	response to xenobiotic stimulus (GO:0009410)	3.28480366
66	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.22337998
67	regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)	3.17681140
68	negative regulation of response to biotic stimulus (GO:0002832)	3.16907721
69	negative regulation of macroautophagy (GO:0016242)	3.16238284
70	positive regulation of immunoglobulin production (GO:0002639)	3.12369804
71	water-soluble vitamin biosynthetic process (GO:0042364)	3.10144298
72	iron-sulfur cluster assembly (GO:0016226)	3.05899865
73	metallo-sulfur cluster assembly (GO:0031163)	3.05899865
74	protein targeting to mitochondrion (GO:0006626)	3.05550184
75	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	3.04127125
76	mRNA catabolic process (GO:0006402)	3.02475995
77	positive regulation of cardiac muscle cell differentiation (GO:2000727)	3.00291614
78	ribonucleoprotein complex biogenesis (GO:0022613)	2.92505926
79	head development (GO:0060322)	2.89756299
80	establishment of protein localization to mitochondrion (GO:0072655)	2.86676014
81	microtubule bundle formation (GO:0001578)	2.83507178
82	regulation of viral entry into host cell (GO:0046596)	2.83099913
83	platelet formation (GO:0030220)	2.82812366
84	nucleotide transmembrane transport (GO:1901679)	2.77296935
85	cellular response to glucocorticoid stimulus (GO:0071385)	2.76923719
86	positive regulation of respiratory burst (GO:0060267)	2.76356425
87	negative regulation of T cell differentiation (GO:0045581)	2.75066431
88	cellular response to ketone (GO:1901655)	2.68945067
89	lung secretory cell differentiation (GO:0061140)	2.68657197
90	protein targeting (GO:0006605)	2.67156807
91	neuromuscular synaptic transmission (GO:0007274)	2.66811012
92	phosphatidylinositol 3-kinase signaling (GO:0014065)	2.66485463
93	RNA catabolic process (GO:0006401)	2.66151442
94	cellular component biogenesis (GO:0044085)	2.64953999
95	protein complex biogenesis (GO:0070271)	2.61927028
96	protein localization to mitochondrion (GO:0070585)	2.55773802
97	protein polyglutamylation (GO:0018095)	2.55477244
98	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.53813690
99	secondary metabolite biosynthetic process (GO:0044550)	2.53377494
100	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	10.3224094

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.54520756
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.04931336
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.42425445
4	VDR_22108803_ChIP-Seq_LS180_Human	3.13268295
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.42980079
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.31137344
7	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.28587274
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.19230320
9	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.08019636
10	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.05456499
11	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.96195526
12	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.94905018
13	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.94069499
14	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.81836592
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.80925946
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.80827352
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.76234499
18	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.72674075
19	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.72527996
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.71649401
21	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.71143732
22	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.66450574
23	GATA1_22025678_ChIP-Seq_K562_Human	1.63640141
24	EWS_26573619_Chip-Seq_HEK293_Human	1.62696328
25	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.62416991
26	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.61763659
27	MYC_19829295_ChIP-Seq_ESCs_Human	1.59602287
28	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.58923540
29	ERA_21632823_ChIP-Seq_H3396_Human	1.54115608
30	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.53318500
31	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.51370003
32	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.49936018
33	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.47586961
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.46588076
35	RNF2_27304074_Chip-Seq_NSC_Mouse	1.45950877
36	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.42789542
37	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.42024077
38	FUS_26573619_Chip-Seq_HEK293_Human	1.41654357
39	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41401790
40	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.40937855
41	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.40533242
42	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.38366128
43	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.38313980
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34603762
45	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.33563163
46	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.32229344
47	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.30836345
48	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.30752777
49	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.30058947
50	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29650707
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29347437
52	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.29154782
53	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.28677133
54	TAF2_19829295_ChIP-Seq_ESCs_Human	1.27466934
55	NCOR_22424771_ChIP-Seq_293T_Human	1.27354627
56	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.26859744
57	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.26314312
58	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.25629710
59	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.25235077
60	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.22418868
61	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.22418868
62	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.20816165
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.17971939
64	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.17321339
65	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.17208930
66	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.11927306
67	BCL6_27268052_Chip-Seq_Bcells_Human	1.11282985
68	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.11208331
69	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.10836615
70	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08639827
71	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.06485171
72	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.06397799
73	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.05597936
74	VDR_23849224_ChIP-Seq_CD4+_Human	1.04784022
75	IRF1_19129219_ChIP-ChIP_H3396_Human	1.04028989
76	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03866261
77	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.02598901
78	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.02049233
79	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00455912
80	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99845618
81	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.99614677
82	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98091671
83	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.97230818
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97194200
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97194200
86	MYC_18940864_ChIP-ChIP_HL60_Human	0.95683805
87	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95246359
88	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.94456886
89	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.94352739
90	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94343596
91	GBX2_23144817_ChIP-Seq_PC3_Human	0.93860954
92	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93048710
93	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.93048710
94	IGF1R_20145208_ChIP-Seq_DFB_Human	0.92764539
95	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.90957516
96	CTCF_20526341_ChIP-Seq_ESCs_Human	0.90541689
97	P300_27268052_Chip-Seq_Bcells_Human	0.89929494
98	E2F1_20622854_ChIP-Seq_HELA_Human	0.89887609
99	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.89843294
100	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.89837577

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.74502974
2	MP0008789_abnormal_olfactory_epithelium	5.49755723
3	MP0005394_taste/olfaction_phenotype	4.48780515
4	MP0005499_abnormal_olfactory_system	4.48780515
5	MP0006292_abnormal_olfactory_placode	4.22176393
6	MP0010386_abnormal_urinary_bladder	2.74926569
7	MP0001348_abnormal_lacrimal_gland	2.46183055
8	MP0001293_anophthalmia	2.42044945
9	MP0009333_abnormal_splenocyte_physiolog	2.21840907
10	MP0004145_abnormal_muscle_electrophysio	2.10523342
11	MP0003122_maternal_imprinting	2.07005224
12	MP0001986_abnormal_taste_sensitivity	1.94316433
13	MP0003693_abnormal_embryo_hatching	1.90483591
14	MP0002163_abnormal_gland_morphology	1.90458231
15	MP0000372_irregular_coat_pigmentation	1.86067946
16	MP0003136_yellow_coat_color	1.85034866
17	MP0004885_abnormal_endolymph	1.83397975
18	MP0005423_abnormal_somatic_nervous	1.74680629
19	MP0004742_abnormal_vestibular_system	1.57931764
20	MP0008875_abnormal_xenobiotic_pharmacok	1.57806035
21	MP0003567_abnormal_fetal_cardiomyocyte	1.54629521
22	MP0003646_muscle_fatigue	1.52615260
23	MP0002653_abnormal_ependyma_morphology	1.52503390
24	MP0001835_abnormal_antigen_presentation	1.46294734
25	MP0002733_abnormal_thermal_nociception	1.44732771
26	MP0009745_abnormal_behavioral_response	1.42230158
27	MP0000778_abnormal_nervous_system	1.38424353
28	MP0001873_stomach_inflammation	1.38347071
29	MP0001968_abnormal_touch/_nociception	1.38274456
30	MP0004142_abnormal_muscle_tone	1.36226758
31	MP0003763_abnormal_thymus_physiology	1.34577976
32	MP0003787_abnormal_imprinting	1.33943658
33	MP0008872_abnormal_physiological_respon	1.33823983
34	MP0002102_abnormal_ear_morphology	1.31915553
35	MP0001790_abnormal_immune_system	1.30901486
36	MP0005387_immune_system_phenotype	1.30901486
37	MP0002233_abnormal_nose_morphology	1.29835188
38	MP0003878_abnormal_ear_physiology	1.26173152
39	MP0005377_hearing/vestibular/ear_phenot	1.26173152
40	MP0000538_abnormal_urinary_bladder	1.23553282
41	MP0002837_dystrophic_cardiac_calcinosis	1.22655550
42	MP0000631_abnormal_neuroendocrine_gland	1.17414286
43	MP0001324_abnormal_eye_pigmentation	1.10000531
44	MP0000685_abnormal_immune_system	1.09429444
45	MP0008877_abnormal_DNA_methylation	1.09316520
46	MP0008775_abnormal_heart_ventricle	1.07844519
47	MP0000955_abnormal_spinal_cord	1.07272303
48	MP0002184_abnormal_innervation	1.06213162
49	MP0005551_abnormal_eye_electrophysiolog	1.06055678
50	MP0006072_abnormal_retinal_apoptosis	1.06025102
51	MP0002638_abnormal_pupillary_reflex	1.05527299
52	MP0004133_heterotaxia	1.05028034
53	MP0001970_abnormal_pain_threshold	1.03278233
54	MP0003937_abnormal_limbs/digits/tail_de	1.01438183
55	MP0003011_delayed_dark_adaptation	1.01048879
56	MP0003121_genomic_imprinting	0.98764006
57	MP0002938_white_spotting	0.97867837
58	MP0002006_tumorigenesis	0.95755933
59	MP0002557_abnormal_social/conspecific_i	0.95028233
60	MP0001440_abnormal_grooming_behavior	0.92915720
61	MP0000750_abnormal_muscle_regeneration	0.92726657
62	MP0009046_muscle_twitch	0.91971416
63	MP0003879_abnormal_hair_cell	0.91447409
64	MP0002234_abnormal_pharynx_morphology	0.89689160
65	MP0001905_abnormal_dopamine_level	0.89663191
66	MP0002736_abnormal_nociception_after	0.89362844
67	MP0001486_abnormal_startle_reflex	0.89011867
68	MP0004381_abnormal_hair_follicle	0.88932083
69	MP0002148_abnormal_hypersensitivity_rea	0.88289608
70	MP0000049_abnormal_middle_ear	0.87893562
71	MP0005671_abnormal_response_to	0.87261922
72	MP0002909_abnormal_adrenal_gland	0.87051724
73	MP0002098_abnormal_vibrissa_morphology	0.86181024
74	MP0006276_abnormal_autonomic_nervous	0.86137116
75	MP0005379_endocrine/exocrine_gland_phen	0.85228987
76	MP0002160_abnormal_reproductive_system	0.80855485
77	MP0002272_abnormal_nervous_system	0.78975088
78	MP0002734_abnormal_mechanical_nocicepti	0.78581042
79	MP0003436_decreased_susceptibility_to	0.78260732
80	MP0008995_early_reproductive_senescence	0.77982429
81	MP0005389_reproductive_system_phenotype	0.77595884
82	MP0001485_abnormal_pinna_reflex	0.77473469
83	MP0002876_abnormal_thyroid_physiology	0.77069761
84	MP0000569_abnormal_digit_pigmentation	0.74925756
85	MP0002572_abnormal_emotion/affect_behav	0.74211278
86	MP0003123_paternal_imprinting	0.73731485
87	MP0005646_abnormal_pituitary_gland	0.71981423
88	MP0000026_abnormal_inner_ear	0.71567501
89	MP0001188_hyperpigmentation	0.70718109
90	MP0005645_abnormal_hypothalamus_physiol	0.69853466
91	MP0004084_abnormal_cardiac_muscle	0.69766928
92	MP0002064_seizures	0.68082777
93	MP0002735_abnormal_chemical_nociception	0.65927079
94	MP0002752_abnormal_somatic_nervous	0.65791312
95	MP0001765_abnormal_ion_homeostasis	0.65235748
96	MP0006036_abnormal_mitochondrial_physio	0.64177180
97	MP0002277_abnormal_respiratory_mucosa	0.63789586
98	MP0002095_abnormal_skin_pigmentation	0.63732984
99	MP0003635_abnormal_synaptic_transmissio	0.62061875
100	MP0001800_abnormal_humoral_immune	0.61727865

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the sacrum (HP:0008517)	6.76687173
2	Abnormal ciliary motility (HP:0012262)	6.66097766
3	Abnormal respiratory motile cilium morphology (HP:0005938)	6.13357548
4	Abnormal respiratory epithelium morphology (HP:0012253)	6.13357548
5	Increased intramyocellular lipid droplets (HP:0012240)	5.33891440
6	Abnormal pupillary function (HP:0007686)	5.06668748
7	Abnormal respiratory motile cilium physiology (HP:0012261)	4.96828302
8	Abnormality of cells of the erythroid lineage (HP:0012130)	4.92754536
9	Chronic sinusitis (HP:0011109)	4.90553496
10	Abnormal number of erythroid precursors (HP:0012131)	4.89243964
11	Increased muscle lipid content (HP:0009058)	4.87203002
12	Stomatitis (HP:0010280)	4.57003442
13	Rhinitis (HP:0012384)	4.18791555
14	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.09683481
15	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.09683481
16	Rectal prolapse (HP:0002035)	4.07564505
17	Maternal diabetes (HP:0009800)	3.96841310
18	Concave nail (HP:0001598)	3.91635699
19	Reticulocytopenia (HP:0001896)	3.73379791
20	Pancreatic cysts (HP:0001737)	3.56883954
21	Increased hepatocellular lipid droplets (HP:0006565)	3.55778592
22	Tubular atrophy (HP:0000092)	3.51296953
23	Lipid accumulation in hepatocytes (HP:0006561)	3.38467711
24	Macrocytic anemia (HP:0001972)	3.38082693
25	Type 2 muscle fiber atrophy (HP:0003554)	3.36824713
26	Nephronophthisis (HP:0000090)	3.27363951
27	Pallor (HP:0000980)	3.15057657
28	Acute encephalopathy (HP:0006846)	3.09743835
29	Areflexia of lower limbs (HP:0002522)	3.05548864
30	Renal Fanconi syndrome (HP:0001994)	3.04662910
31	Muscle fiber atrophy (HP:0100295)	3.02134387
32	Exercise intolerance (HP:0003546)	3.00794211
33	Acute necrotizing encephalopathy (HP:0006965)	2.97912354
34	Asplenia (HP:0001746)	2.97254160
35	Anencephaly (HP:0002323)	2.96784960
36	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.94936669
37	Abnormality of the musculature of the hand (HP:0001421)	2.85309029
38	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.84856341
39	Myelomeningocele (HP:0002475)	2.83445295
40	Abnormal mitochondria in muscle tissue (HP:0008316)	2.59202217
41	Bronchiectasis (HP:0002110)	2.59166048
42	Abnormality of the renal cortex (HP:0011035)	2.57432746
43	Exertional dyspnea (HP:0002875)	2.53778040
44	Mitochondrial inheritance (HP:0001427)	2.52015152
45	Abnormality of the renal medulla (HP:0100957)	2.48081033
46	Hyperglycinemia (HP:0002154)	2.46390626
47	3-Methylglutaconic aciduria (HP:0003535)	2.40052606
48	Horseshoe kidney (HP:0000085)	2.34830539
49	Progressive macrocephaly (HP:0004481)	2.32831806
50	Episodic fever (HP:0001954)	2.32824314
51	Abnormality of midbrain morphology (HP:0002418)	2.32214176
52	Molar tooth sign on MRI (HP:0002419)	2.32214176
53	Congenital stationary night blindness (HP:0007642)	2.30968038
54	Decreased central vision (HP:0007663)	2.29581390
55	Optic nerve coloboma (HP:0000588)	2.25123183
56	Down-sloping shoulders (HP:0200021)	2.24285808
57	Anophthalmia (HP:0000528)	2.20769029
58	Abnormal number of incisors (HP:0011064)	2.19442673
59	Difficulty running (HP:0009046)	2.18348806
60	Microretrognathia (HP:0000308)	2.18007310
61	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.15571019
62	Increased CSF lactate (HP:0002490)	2.13962249
63	Abnormal hemoglobin (HP:0011902)	2.13508568
64	Abnormality of renal resorption (HP:0011038)	2.12346664
65	Methylmalonic acidemia (HP:0002912)	2.10952153
66	Pancreatic fibrosis (HP:0100732)	2.09512225
67	Respiratory difficulties (HP:0002880)	2.05833347
68	Partial agenesis of the corpus callosum (HP:0001338)	2.03206945
69	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.00059376
70	Abnormal rod and cone electroretinograms (HP:0008323)	1.97145572
71	Lymphangioma (HP:0100764)	1.94095601
72	Palpitations (HP:0001962)	1.92073024
73	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.86280273
74	Fatigable weakness (HP:0003473)	1.85674902
75	Abnormality of the neuromuscular junction (HP:0003398)	1.85674902
76	Agitation (HP:0000713)	1.83040883
77	Multiple enchondromatosis (HP:0005701)	1.81107764
78	Bowel incontinence (HP:0002607)	1.80860507
79	Depressed nasal ridge (HP:0000457)	1.79162281
80	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.77057298
81	Congenital, generalized hypertrichosis (HP:0004540)	1.76114269
82	True hermaphroditism (HP:0010459)	1.75503165
83	Premature skin wrinkling (HP:0100678)	1.73548324
84	Cerebral edema (HP:0002181)	1.72352868
85	Joint hemorrhage (HP:0005261)	1.71680139
86	Oligodontia (HP:0000677)	1.70964389
87	Spontaneous hematomas (HP:0007420)	1.70386701
88	Restlessness (HP:0000711)	1.69861726
89	Hyperphosphaturia (HP:0003109)	1.67623482
90	Abnormality of urine glucose concentration (HP:0011016)	1.64768548
91	Glycosuria (HP:0003076)	1.64768548
92	Easy fatigability (HP:0003388)	1.64687570
93	Abnormal large intestine physiology (HP:0012700)	1.64328263
94	Pendular nystagmus (HP:0012043)	1.63771910
95	Hyperthyroidism (HP:0000836)	1.61927020
96	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.59826825
97	Optic disc pallor (HP:0000543)	1.59618578
98	Hypoplasia of the uterus (HP:0000013)	1.59248529
99	Vesicoureteral reflux (HP:0000076)	1.58818832
100	Triphalangeal thumb (HP:0001199)	1.56568798

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP2K2	5.40716299
2	TNK2	4.25466400
3	NEK9	4.14417305
4	EIF2AK1	3.91335225
5	MAP3K4	3.31009783
6	MUSK	3.13743825
7	MAP2K1	2.83821136
8	BUB1	2.67011852
9	DYRK2	2.64245551
10	MKNK2	2.62127327
11	DYRK1A	2.59826450
12	ADRBK2	2.36658526
13	STK38L	1.97729528
14	NME2	1.95804743
15	AKT3	1.93283434
16	WNK4	1.76325783
17	MAP4K2	1.70677465
18	MKNK1	1.66734643
19	SGK494	1.51510538
20	SGK223	1.51510538
21	GRK1	1.47066982
22	TLK1	1.36082237
23	PINK1	1.25873050
24	MARK3	1.16602749
25	RPS6KA6	1.13794178
26	TXK	1.13441422
27	PLK4	1.10042539
28	BRAF	1.04955985
29	NME1	0.97503874
30	BTK	0.96944098
31	PRKCQ	0.96567358
32	TIE1	0.96143903
33	NTRK2	0.94047031
34	PRKCZ	0.91758204
35	NTRK3	0.86423164
36	GRK7	0.83819293
37	ADRBK1	0.83750936
38	STK39	0.81338486
39	PIK3CA	0.79241905
40	INSRR	0.78948878
41	MAPK13	0.78148023
42	EPHB2	0.77466711
43	DYRK1B	0.75240565
44	RPS6KA5	0.74873231
45	FRK	0.74712041
46	TEC	0.73537284
47	RPS6KL1	0.71394280
48	RPS6KC1	0.71394280
49	BCKDK	0.71342790
50	MAP3K12	0.70179129
51	ERBB2	0.68869578
52	ZAK	0.67729939
53	LRRK2	0.67308272
54	WNK3	0.66938183
55	RPS6KB2	0.66227336
56	PRKCG	0.65266617
57	STK11	0.63721407
58	LIMK1	0.63178558
59	PAK6	0.63072913
60	SGK1	0.62668001
61	PRKACA	0.60587437
62	OBSCN	0.59952103
63	PAK3	0.57731192
64	CAMK1	0.56635111
65	CSNK2A1	0.56444642
66	ABL1	0.54964903
67	CSNK2A2	0.54896614
68	MAPK15	0.51914438
69	RPS6KA1	0.50770218
70	PIM2	0.49990231
71	OXSR1	0.46234986
72	CAMK2A	0.45201945
73	PHKG1	0.43328152
74	PHKG2	0.43328152
75	DYRK3	0.42146866
76	PRKD3	0.41157619
77	MAPKAPK5	0.39786838
78	BMPR1B	0.39576553
79	PRKCA	0.38973873
80	RPS6KA2	0.37145401
81	CAMKK2	0.36916501
82	AURKA	0.35888078
83	AURKB	0.34455979
84	CASK	0.34163930
85	FES	0.31882557
86	EPHA4	0.30955374
87	MOS	0.29692988
88	ILK	0.28949521
89	GRK5	0.28557239
90	DAPK3	0.28231977
91	NEK2	0.27225658
92	RPS6KA3	0.26936395
93	MYLK	0.26726830
94	STK16	0.26123278
95	PRKACG	0.26061920
96	MAPK3	0.25915703
97	AKT1	0.25646464
98	NTRK1	0.25462950
99	MAPK14	0.25410975
100	ERBB4	0.24500897

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.40289661
2	Asthma_Homo sapiens_hsa05310	5.05379353
3	Allograft rejection_Homo sapiens_hsa05330	4.25624838
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.83789229
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.67728615
6	Graft-versus-host disease_Homo sapiens_hsa05332	3.27391116
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.96754346
8	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.57656414
9	Viral myocarditis_Homo sapiens_hsa05416	2.55953410
10	Parkinsons disease_Homo sapiens_hsa05012	2.15390697
11	Oxidative phosphorylation_Homo sapiens_hsa00190	1.86957031
12	Antigen processing and presentation_Homo sapiens_hsa04612	1.73530743
13	Propanoate metabolism_Homo sapiens_hsa00640	1.57686641
14	Primary immunodeficiency_Homo sapiens_hsa05340	1.53349086
15	Phototransduction_Homo sapiens_hsa04744	1.52116077
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.44216755
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.44131233
18	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.43593326
19	Huntingtons disease_Homo sapiens_hsa05016	1.34457950
20	Alzheimers disease_Homo sapiens_hsa05010	1.32604257
21	Rheumatoid arthritis_Homo sapiens_hsa05323	1.30463360
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.29088867
23	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.20098893
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.10237537
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.09893873
26	beta-Alanine metabolism_Homo sapiens_hsa00410	1.08910544
27	RNA polymerase_Homo sapiens_hsa03020	1.05911366
28	Melanoma_Homo sapiens_hsa05218	1.01928693
29	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.00293577
30	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.99695544
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98680115
32	VEGF signaling pathway_Homo sapiens_hsa04370	0.95493598
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92650831
34	One carbon pool by folate_Homo sapiens_hsa00670	0.91021857
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.89445253
36	Leishmaniasis_Homo sapiens_hsa05140	0.88136243
37	Colorectal cancer_Homo sapiens_hsa05210	0.87212417
38	Olfactory transduction_Homo sapiens_hsa04740	0.84832311
39	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.84493584
40	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.84182810
41	Toxoplasmosis_Homo sapiens_hsa05145	0.83969571
42	Endometrial cancer_Homo sapiens_hsa05213	0.82788457
43	Nicotine addiction_Homo sapiens_hsa05033	0.82559234
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.73225378
45	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.73084922
46	Regulation of autophagy_Homo sapiens_hsa04140	0.71728762
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.69270598
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64675376
49	Non-small cell lung cancer_Homo sapiens_hsa05223	0.60613555
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60584923
51	Nitrogen metabolism_Homo sapiens_hsa00910	0.59071281
52	Butanoate metabolism_Homo sapiens_hsa00650	0.59011167
53	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.58208736
54	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.57967556
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57908854
56	Taste transduction_Homo sapiens_hsa04742	0.57493844
57	Caffeine metabolism_Homo sapiens_hsa00232	0.56869161
58	Phenylalanine metabolism_Homo sapiens_hsa00360	0.55371694
59	Tryptophan metabolism_Homo sapiens_hsa00380	0.55248664
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.54070880
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53441925
62	p53 signaling pathway_Homo sapiens_hsa04115	0.51845706
63	Basal transcription factors_Homo sapiens_hsa03022	0.51644565
64	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.48921645
65	Retinol metabolism_Homo sapiens_hsa00830	0.48595418
66	Sulfur relay system_Homo sapiens_hsa04122	0.48549590
67	Proteasome_Homo sapiens_hsa03050	0.47786627
68	Protein export_Homo sapiens_hsa03060	0.46543390
69	Ether lipid metabolism_Homo sapiens_hsa00565	0.46504159
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.45408027
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44015025
72	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.43951097
73	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.43173084
74	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.42703648
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42589381
76	Fanconi anemia pathway_Homo sapiens_hsa03460	0.41768935
77	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.37538097
78	Influenza A_Homo sapiens_hsa05164	0.37352472
79	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.36538709
80	Pancreatic cancer_Homo sapiens_hsa05212	0.36516341
81	Tyrosine metabolism_Homo sapiens_hsa00350	0.36060706
82	Serotonergic synapse_Homo sapiens_hsa04726	0.35237153
83	Morphine addiction_Homo sapiens_hsa05032	0.35039684
84	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.34140621
85	Sphingolipid metabolism_Homo sapiens_hsa00600	0.33879190
86	Pyrimidine metabolism_Homo sapiens_hsa00240	0.29344782
87	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.26968980
88	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.25427497
89	Homologous recombination_Homo sapiens_hsa03440	0.24556825
90	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.24420468
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.23952008
92	Type II diabetes mellitus_Homo sapiens_hsa04930	0.23223706
93	Selenocompound metabolism_Homo sapiens_hsa00450	0.22285496
94	Calcium signaling pathway_Homo sapiens_hsa04020	0.22153535
95	Tuberculosis_Homo sapiens_hsa05152	0.21618595
96	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.19840705
97	Folate biosynthesis_Homo sapiens_hsa00790	0.19309108
98	Purine metabolism_Homo sapiens_hsa00230	0.18935993
99	Choline metabolism in cancer_Homo sapiens_hsa05231	0.17419366
100	Basal cell carcinoma_Homo sapiens_hsa05217	0.17106699

RPL32P33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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