ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.15166252
2	translational termination (GO:0006415)	6.82093201
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.44484732
4	ATP synthesis coupled proton transport (GO:0015986)	6.44484732
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.38061129
6	ribosomal small subunit assembly (GO:0000028)	6.17282295
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.97876505
8	translational elongation (GO:0006414)	5.93800361
9	ribosomal small subunit biogenesis (GO:0042274)	5.93760704
10	protein targeting to ER (GO:0045047)	5.87152472
11	cotranslational protein targeting to membrane (GO:0006613)	5.86605441
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.57815100
13	chaperone-mediated protein transport (GO:0072321)	5.55867699
14	protein localization to endoplasmic reticulum (GO:0070972)	5.50466773
15	viral life cycle (GO:0019058)	5.27489704
16	cellular protein complex disassembly (GO:0043624)	5.17939210
17	maturation of SSU-rRNA (GO:0030490)	5.12246327
18	DNA deamination (GO:0045006)	5.05370730
19	behavioral response to nicotine (GO:0035095)	4.98791732
20	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.90104122
21	translational initiation (GO:0006413)	4.64850059
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.42983309
23	ribosomal large subunit biogenesis (GO:0042273)	4.40636061
24	protein complex disassembly (GO:0043241)	4.25423444
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.23621871
26	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.23621871
27	NADH dehydrogenase complex assembly (GO:0010257)	4.23621871
28	protein complex biogenesis (GO:0070271)	4.21951353
29	electron transport chain (GO:0022900)	4.12991624
30	respiratory electron transport chain (GO:0022904)	4.12042507
31	translation (GO:0006412)	4.06286161
32	positive regulation of prostaglandin secretion (GO:0032308)	4.05229547
33	macromolecular complex disassembly (GO:0032984)	4.01557162
34	protein neddylation (GO:0045116)	3.93755446
35	mitochondrial respiratory chain complex assembly (GO:0033108)	3.92420349
36	GTP biosynthetic process (GO:0006183)	3.89883984
37	protein targeting to membrane (GO:0006612)	3.83550824
38	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.81160239
39	ATP biosynthetic process (GO:0006754)	3.78405372
40	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.77417410
41	regulation of isotype switching to IgG isotypes (GO:0048302)	3.58877736
42	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.50433683
43	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.48949531
44	positive regulation of fatty acid transport (GO:2000193)	3.45765668
45	cellular component biogenesis (GO:0044085)	3.39874314
46	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.36380356
47	positive regulation of icosanoid secretion (GO:0032305)	3.34658406
48	mRNA catabolic process (GO:0006402)	3.32135222
49	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.29827765
50	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.29827765
51	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.27661415
52	ribonucleoprotein complex biogenesis (GO:0022613)	3.25644388
53	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.23462254
54	UTP biosynthetic process (GO:0006228)	3.18777195
55	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.17070428
56	water-soluble vitamin biosynthetic process (GO:0042364)	3.12424128
57	hydrogen ion transmembrane transport (GO:1902600)	3.05165887
58	regulation of prostaglandin secretion (GO:0032306)	3.04540441
59	L-fucose catabolic process (GO:0042355)	3.03206289
60	fucose catabolic process (GO:0019317)	3.03206289
61	L-fucose metabolic process (GO:0042354)	3.03206289
62	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.00255246
63	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.98776845
64	RNA catabolic process (GO:0006401)	2.97436488
65	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.97362571
66	UTP metabolic process (GO:0046051)	2.93037894
67	pseudouridine synthesis (GO:0001522)	2.91782230
68	cytidine catabolic process (GO:0006216)	2.90075273
69	cytidine deamination (GO:0009972)	2.90075273
70	cytidine metabolic process (GO:0046087)	2.90075273
71	proton transport (GO:0015992)	2.81386148
72	nucleoside triphosphate biosynthetic process (GO:0009142)	2.81352348
73	protein-cofactor linkage (GO:0018065)	2.79813052
74	peptidyl-histidine modification (GO:0018202)	2.79358362
75	hydrogen transport (GO:0006818)	2.78801524
76	intracellular protein transmembrane import (GO:0044743)	2.77796928
77	metallo-sulfur cluster assembly (GO:0031163)	2.77686123
78	iron-sulfur cluster assembly (GO:0016226)	2.77686123
79	negative regulation of mast cell activation (GO:0033004)	2.77097373
80	pyrimidine nucleotide catabolic process (GO:0006244)	2.76079804
81	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.71140719
82	protein targeting to mitochondrion (GO:0006626)	2.70755967
83	maturation of 5.8S rRNA (GO:0000460)	2.70401995
84	rRNA processing (GO:0006364)	2.69801771
85	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.69335373
86	respiratory chain complex IV assembly (GO:0008535)	2.66626943
87	CTP biosynthetic process (GO:0006241)	2.64949376
88	CTP metabolic process (GO:0046036)	2.64949376
89	somite development (GO:0061053)	2.64692839
90	rRNA metabolic process (GO:0016072)	2.63865218
91	nonmotile primary cilium assembly (GO:0035058)	2.63223893
92	regulation of chronic inflammatory response (GO:0002676)	2.62575736
93	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.62334716
94	negative regulation of telomere maintenance (GO:0032205)	2.62245001
95	base-excision repair, AP site formation (GO:0006285)	2.61316705
96	protein targeting (GO:0006605)	2.60332208
97	termination of RNA polymerase III transcription (GO:0006386)	2.59914404
98	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.59914404
99	cytochrome complex assembly (GO:0017004)	2.59880169
100	tRNA processing (GO:0008033)	2.58858227

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.79946267
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.70643781
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.61332739
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.58442401
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.14970544
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.12283536
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.04934264
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.98979440
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.78238887
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.72214451
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.55217902
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.55167788
13	VDR_22108803_ChIP-Seq_LS180_Human	2.54163064
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.03388433
15	VDR_23849224_ChIP-Seq_CD4+_Human	1.99393891
16	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.97239436
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93399720
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.87319162
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.83848895
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.82819275
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.80645820
22	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.78652933
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73748280
24	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.65860003
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.59240910
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.58488155
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.56912118
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.54346056
29	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.52294770
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.51997667
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.51248297
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.50411761
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.50148648
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.49956978
35	FUS_26573619_Chip-Seq_HEK293_Human	1.48503254
36	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.46625553
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.46109095
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.42025053
39	EWS_26573619_Chip-Seq_HEK293_Human	1.40454810
40	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.40075056
41	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.37284298
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34349131
43	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.34160778
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29403247
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.28404390
46	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.27467976
47	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25381668
48	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.25006161
49	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.24990140
50	NCOR_22424771_ChIP-Seq_293T_Human	1.23539064
51	TAF2_19829295_ChIP-Seq_ESCs_Human	1.22433138
52	XRN2_22483619_ChIP-Seq_HELA_Human	1.22299240
53	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.21110317
54	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.20003550
55	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19217614
56	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.19003641
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18744138
58	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.18389844
59	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18175719
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18175719
61	AR_20517297_ChIP-Seq_VCAP_Human	1.17279809
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16929451
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16929451
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16148225
65	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.15300849
66	ERA_21632823_ChIP-Seq_H3396_Human	1.15268223
67	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14394844
68	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.13157681
69	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.12998098
70	NANOG_20526341_ChIP-Seq_ESCs_Human	1.12402085
71	P300_19829295_ChIP-Seq_ESCs_Human	1.12142823
72	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11495992
73	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.11457400
74	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.11121705
75	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.10204518
76	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.08074439
77	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.03942739
78	ER_23166858_ChIP-Seq_MCF-7_Human	1.03678003
79	TAF15_26573619_Chip-Seq_HEK293_Human	1.02989444
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02455706
81	CBP_20019798_ChIP-Seq_JUKART_Human	1.02455706
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99458130
83	REST_21632747_ChIP-Seq_MESCs_Mouse	0.98802718
84	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.98503402
85	CTCF_20526341_ChIP-Seq_ESCs_Human	0.97050972
86	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.96962856
87	MYC_19829295_ChIP-Seq_ESCs_Human	0.96874368
88	GABP_19822575_ChIP-Seq_HepG2_Human	0.93180801
89	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.92322297
90	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.91717376
91	ERG_20517297_ChIP-Seq_VCAP_Human	0.91481949
92	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.91414330
93	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.90668065
94	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.89144772
95	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.88833314
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.88815495
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.88627831
98	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.88434429
99	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.88302365
100	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.88223768

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.31853486
2	MP0002102_abnormal_ear_morphology	4.12563534
3	MP0006292_abnormal_olfactory_placode	3.28881683
4	MP0003646_muscle_fatigue	2.58874171
5	MP0001968_abnormal_touch/_nociception	2.54744582
6	MP0008789_abnormal_olfactory_epithelium	2.39429066
7	MP0002653_abnormal_ependyma_morphology	2.36825722
8	MP0002163_abnormal_gland_morphology	2.34919775
9	MP0002638_abnormal_pupillary_reflex	2.13151102
10	MP0005499_abnormal_olfactory_system	2.11977116
11	MP0005394_taste/olfaction_phenotype	2.11977116
12	MP0005671_abnormal_response_to	2.09320072
13	MP0001529_abnormal_vocalization	2.08284620
14	MP0002736_abnormal_nociception_after	2.06743862
15	MP0005646_abnormal_pituitary_gland	2.03021579
16	MP0005551_abnormal_eye_electrophysiolog	1.94580400
17	MP0005645_abnormal_hypothalamus_physiol	1.89827913
18	MP0002938_white_spotting	1.85409209
19	MP0006072_abnormal_retinal_apoptosis	1.74624197
20	MP0006276_abnormal_autonomic_nervous	1.68744755
21	MP0004142_abnormal_muscle_tone	1.66183125
22	MP0000049_abnormal_middle_ear	1.65388183
23	MP0008872_abnormal_physiological_respon	1.60604745
24	MP0002277_abnormal_respiratory_mucosa	1.56986303
25	MP0000372_irregular_coat_pigmentation	1.52410737
26	MP0004885_abnormal_endolymph	1.48865292
27	MP0008875_abnormal_xenobiotic_pharmacok	1.45761302
28	MP0001905_abnormal_dopamine_level	1.44910973
29	MP0003011_delayed_dark_adaptation	1.43598770
30	MP0004145_abnormal_muscle_electrophysio	1.37290925
31	MP0005379_endocrine/exocrine_gland_phen	1.36112836
32	MP0008877_abnormal_DNA_methylation	1.34105224
33	MP0009745_abnormal_behavioral_response	1.32659344
34	MP0000631_abnormal_neuroendocrine_gland	1.32536363
35	MP0002837_dystrophic_cardiac_calcinosis	1.31733517
36	MP0004147_increased_porphyrin_level	1.25552029
37	MP0002095_abnormal_skin_pigmentation	1.23425782
38	MP0002876_abnormal_thyroid_physiology	1.22583827
39	MP0003880_abnormal_central_pattern	1.21679195
40	MP0003878_abnormal_ear_physiology	1.20766910
41	MP0005377_hearing/vestibular/ear_phenot	1.20766910
42	MP0002272_abnormal_nervous_system	1.20114978
43	MP0001984_abnormal_olfaction	1.20037587
44	MP0002735_abnormal_chemical_nociception	1.18602262
45	MP0000026_abnormal_inner_ear	1.15075606
46	MP0005253_abnormal_eye_physiology	1.14590165
47	MP0001440_abnormal_grooming_behavior	1.13011717
48	MP0002160_abnormal_reproductive_system	1.12891689
49	MP0003122_maternal_imprinting	1.12524217
50	MP0005084_abnormal_gallbladder_morpholo	1.10652076
51	MP0001485_abnormal_pinna_reflex	1.10621432
52	MP0002557_abnormal_social/conspecific_i	1.09124992
53	MP0002234_abnormal_pharynx_morphology	1.07932493
54	MP0005085_abnormal_gallbladder_physiolo	1.07911040
55	MP0001986_abnormal_taste_sensitivity	1.05390921
56	MP0005389_reproductive_system_phenotype	1.04216955
57	MP0001970_abnormal_pain_threshold	1.03694048
58	MP0001835_abnormal_antigen_presentation	1.02241258
59	MP0006036_abnormal_mitochondrial_physio	1.01244146
60	MP0003136_yellow_coat_color	0.97819224
61	MP0008058_abnormal_DNA_repair	0.94307944
62	MP0002734_abnormal_mechanical_nocicepti	0.92409630
63	MP0001963_abnormal_hearing_physiology	0.90434146
64	MP0005387_immune_system_phenotype	0.90070208
65	MP0001790_abnormal_immune_system	0.90070208
66	MP0009046_muscle_twitch	0.88448460
67	MP0005195_abnormal_posterior_eye	0.87038021
68	MP0001293_anophthalmia	0.86843909
69	MP0003186_abnormal_redox_activity	0.86362160
70	MP0002572_abnormal_emotion/affect_behav	0.83545988
71	MP0010030_abnormal_orbit_morphology	0.83069558
72	MP0002909_abnormal_adrenal_gland	0.82636986
73	MP0001919_abnormal_reproductive_system	0.82021516
74	MP0002752_abnormal_somatic_nervous	0.81777025
75	MP0000685_abnormal_immune_system	0.81189982
76	MP0009764_decreased_sensitivity_to	0.80165040
77	MP0003938_abnormal_ear_development	0.79710153
78	MP0001800_abnormal_humoral_immune	0.79681219
79	MP0003787_abnormal_imprinting	0.77788493
80	MP0003195_calcinosis	0.76319246
81	MP0005386_behavior/neurological_phenoty	0.76247981
82	MP0004924_abnormal_behavior	0.76247981
83	MP0002733_abnormal_thermal_nociception	0.75197079
84	MP0008995_early_reproductive_senescence	0.74968944
85	MP0008775_abnormal_heart_ventricle	0.74648942
86	MP0009785_altered_susceptibility_to	0.74634285
87	MP0003879_abnormal_hair_cell	0.74513267
88	MP0003693_abnormal_embryo_hatching	0.74383036
89	MP0002148_abnormal_hypersensitivity_rea	0.74224630
90	MP0001663_abnormal_digestive_system	0.71909078
91	MP0004782_abnormal_surfactant_physiolog	0.71534674
92	MP0002184_abnormal_innervation	0.71100451
93	MP0005448_abnormal_energy_balance	0.70140948
94	MP0000566_synostosis	0.69253852
95	MP0002233_abnormal_nose_morphology	0.69242185
96	MP0001486_abnormal_startle_reflex	0.69067132
97	MP0005332_abnormal_amino_acid	0.67273201
98	MP0010386_abnormal_urinary_bladder	0.67242785
99	MP0003121_genomic_imprinting	0.66618924
100	MP0001764_abnormal_homeostasis	0.65811495

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.62375437
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.15618485
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.09780506
4	Mitochondrial inheritance (HP:0001427)	4.03710917
5	3-Methylglutaconic aciduria (HP:0003535)	4.02885485
6	Increased hepatocellular lipid droplets (HP:0006565)	3.80292163
7	Acute encephalopathy (HP:0006846)	3.78375555
8	Progressive macrocephaly (HP:0004481)	3.71413410
9	Abnormality of cells of the erythroid lineage (HP:0012130)	3.61271190
10	Increased CSF lactate (HP:0002490)	3.60123098
11	Lipid accumulation in hepatocytes (HP:0006561)	3.52197071
12	Macrocytic anemia (HP:0001972)	3.51944682
13	Reticulocytopenia (HP:0001896)	3.50219164
14	Renal Fanconi syndrome (HP:0001994)	3.44494344
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.40305374
16	Pendular nystagmus (HP:0012043)	3.27870477
17	Abnormal number of erythroid precursors (HP:0012131)	3.22605195
18	Increased intramyocellular lipid droplets (HP:0012240)	3.15250288
19	Pancreatic cysts (HP:0001737)	3.12769528
20	Pancreatic fibrosis (HP:0100732)	3.00349735
21	Abnormality of midbrain morphology (HP:0002418)	2.99820067
22	Molar tooth sign on MRI (HP:0002419)	2.99820067
23	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.91981642
24	Hepatocellular necrosis (HP:0001404)	2.87783274
25	Cerebral edema (HP:0002181)	2.85514817
26	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.84179034
27	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.84179034
28	Pallor (HP:0000980)	2.80613402
29	Congenital stationary night blindness (HP:0007642)	2.67972010
30	Optic disc pallor (HP:0000543)	2.67814252
31	True hermaphroditism (HP:0010459)	2.65169722
32	Stenosis of the external auditory canal (HP:0000402)	2.65141779
33	Nephronophthisis (HP:0000090)	2.61841389
34	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.60401582
35	Absent/shortened dynein arms (HP:0200106)	2.60401582
36	Increased muscle lipid content (HP:0009058)	2.59045161
37	Hepatic necrosis (HP:0002605)	2.55883140
38	Abnormality of renal resorption (HP:0011038)	2.54775857
39	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.51049998
40	Decreased central vision (HP:0007663)	2.49417567
41	Polydipsia (HP:0001959)	2.44202858
42	Abnormal drinking behavior (HP:0030082)	2.44202858
43	Exertional dyspnea (HP:0002875)	2.43816487
44	Attenuation of retinal blood vessels (HP:0007843)	2.40383343
45	Abnormal respiratory epithelium morphology (HP:0012253)	2.39606190
46	Abnormal respiratory motile cilium morphology (HP:0005938)	2.39606190
47	Tubular atrophy (HP:0000092)	2.38622597
48	Increased serum lactate (HP:0002151)	2.38501015
49	Increased corneal curvature (HP:0100692)	2.34447170
50	Keratoconus (HP:0000563)	2.34447170
51	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.29723053
52	Asplenia (HP:0001746)	2.24885723
53	Lactic acidosis (HP:0003128)	2.23178749
54	Medial flaring of the eyebrow (HP:0010747)	2.20132203
55	Abnormality of the renal cortex (HP:0011035)	2.19869309
56	Abnormality of the renal medulla (HP:0100957)	2.19821718
57	Polyuria (HP:0000103)	2.16569691
58	Abnormality of the labia minora (HP:0012880)	2.15311009
59	Abolished electroretinogram (ERG) (HP:0000550)	2.14564616
60	Glycosuria (HP:0003076)	2.13824190
61	Abnormality of urine glucose concentration (HP:0011016)	2.13824190
62	Septo-optic dysplasia (HP:0100842)	2.13359502
63	IgG deficiency (HP:0004315)	2.09631144
64	Exercise intolerance (HP:0003546)	2.07182273
65	Absent thumb (HP:0009777)	2.06979891
66	Hyperphosphaturia (HP:0003109)	2.06322311
67	Lethargy (HP:0001254)	2.06071060
68	Elevated erythrocyte sedimentation rate (HP:0003565)	2.04200344
69	Dyskinesia (HP:0100660)	2.01135566
70	Type II lissencephaly (HP:0007260)	2.00308645
71	Increased IgM level (HP:0003496)	1.99406820
72	Abnormal ciliary motility (HP:0012262)	1.98936485
73	Congenital, generalized hypertrichosis (HP:0004540)	1.92130893
74	Sclerocornea (HP:0000647)	1.91967216
75	Leukodystrophy (HP:0002415)	1.90929114
76	Cystic liver disease (HP:0006706)	1.90304810
77	Abnormal respiratory motile cilium physiology (HP:0012261)	1.89981336
78	Respiratory failure (HP:0002878)	1.87478349
79	Rib fusion (HP:0000902)	1.86088054
80	Abnormal urine output (HP:0012590)	1.85292672
81	Anencephaly (HP:0002323)	1.84353449
82	Hypoplasia of the radius (HP:0002984)	1.83040971
83	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.77819635
84	Bile duct proliferation (HP:0001408)	1.76195083
85	Abnormal biliary tract physiology (HP:0012439)	1.76195083
86	Chronic hepatic failure (HP:0100626)	1.75707198
87	Bony spicule pigmentary retinopathy (HP:0007737)	1.75566194
88	Colon cancer (HP:0003003)	1.74774404
89	Abnormality of the 4th metacarpal (HP:0010012)	1.73983317
90	Aplastic anemia (HP:0001915)	1.72831828
91	Hypoplasia of the ulna (HP:0003022)	1.71733528
92	Testicular atrophy (HP:0000029)	1.70133753
93	Abnormality of renal excretion (HP:0011036)	1.68566045
94	Gait imbalance (HP:0002141)	1.68390205
95	Decreased circulating renin level (HP:0003351)	1.68086506
96	Lissencephaly (HP:0001339)	1.66677555
97	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.65594337
98	X-linked dominant inheritance (HP:0001423)	1.65188213
99	Hypoproteinemia (HP:0003075)	1.64482309
100	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.63992834

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.74904271
2	ADRBK2	3.35475917
3	STK16	2.81382874
4	MAP4K2	2.79592734
5	WNK4	2.60327459
6	NME2	2.56765492
7	TXK	2.44328027
8	BCKDK	2.36574982
9	GRK1	2.32276310
10	ZAK	2.17361839
11	TIE1	2.01356851
12	WNK3	1.89355169
13	MAP4K1	1.84621121
14	DYRK2	1.79179321
15	MAPK13	1.75729129
16	NUAK1	1.70308496
17	FRK	1.51563343
18	TSSK6	1.50610313
19	STK39	1.50328613
20	PINK1	1.41991506
21	INSRR	1.39725465
22	CDK19	1.38687009
23	BMPR1B	1.35288708
24	PASK	1.35241417
25	CAMKK2	1.35119995
26	MAP3K11	1.29113225
27	KDR	1.28467993
28	TEC	1.22265172
29	LIMK1	1.19658363
30	OXSR1	1.13875763
31	TAOK3	1.12611213
32	ADRBK1	1.06923682
33	PRKCG	1.02934298
34	SRPK1	1.01458094
35	LRRK2	0.98042230
36	RPS6KA5	0.97116026
37	PAK3	0.94477086
38	VRK2	0.94193741
39	ITK	0.92962176
40	VRK1	0.90950754
41	ABL2	0.90892366
42	NME1	0.90854606
43	NTRK3	0.90328442
44	MAPK15	0.89011592
45	MAPKAPK3	0.86320472
46	NEK1	0.85892965
47	MAP2K7	0.83846704
48	CASK	0.83150156
49	NTRK2	0.82708372
50	MUSK	0.81182997
51	PIK3CA	0.79998660
52	PHKG2	0.79993130
53	PHKG1	0.79993130
54	DAPK2	0.79911713
55	PRKACA	0.74187042
56	PDK2	0.71111312
57	PRKCQ	0.70163159
58	EPHB2	0.69828133
59	OBSCN	0.69805517
60	MAP3K4	0.68900022
61	BCR	0.67678389
62	CSNK1G2	0.67455365
63	CAMK1	0.65294424
64	PLK4	0.64361499
65	MARK1	0.64353820
66	CSNK2A1	0.64089958
67	EPHA4	0.63321832
68	TRIM28	0.62423094
69	MINK1	0.62204154
70	CAMK2A	0.61735135
71	CAMKK1	0.61670034
72	CSNK2A2	0.61131507
73	CDK8	0.60936573
74	MAP3K12	0.60783443
75	AURKB	0.60552768
76	LCK	0.59863539
77	CSNK1G3	0.59514393
78	ERBB2	0.58083328
79	BTK	0.57269704
80	DYRK1B	0.57124388
81	TGFBR1	0.56379736
82	MAP2K6	0.56176384
83	IKBKB	0.53921814
84	CSNK1A1	0.53710011
85	MATK	0.52992901
86	PLK1	0.52077033
87	PRKCA	0.50334512
88	LYN	0.50193369
89	PLK3	0.49578408
90	GRK7	0.47444772
91	EIF2AK1	0.47390646
92	SYK	0.47085650
93	ATR	0.44821042
94	EPHA3	0.43413892
95	PIM1	0.42759442
96	GRK6	0.42037036
97	AURKA	0.41674345
98	CLK1	0.40182108
99	PRKG1	0.38274849
100	RPS6KA6	0.37693852

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.76050145
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.21687094
3	Parkinsons disease_Homo sapiens_hsa05012	3.38724560
4	Sulfur relay system_Homo sapiens_hsa04122	2.51029475
5	Proteasome_Homo sapiens_hsa03050	2.33091242
6	Huntingtons disease_Homo sapiens_hsa05016	2.29917447
7	Alzheimers disease_Homo sapiens_hsa05010	2.29551340
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.27784777
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.06755289
10	Asthma_Homo sapiens_hsa05310	2.05911356
11	Protein export_Homo sapiens_hsa03060	2.04125532
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.00140334
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.91130651
14	RNA polymerase_Homo sapiens_hsa03020	1.82495242
15	Phototransduction_Homo sapiens_hsa04744	1.82180221
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.78373556
17	Primary immunodeficiency_Homo sapiens_hsa05340	1.66774103
18	Allograft rejection_Homo sapiens_hsa05330	1.60504806
19	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.60007273
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.59808953
21	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.58868581
22	One carbon pool by folate_Homo sapiens_hsa00670	1.57336063
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.56288497
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.54670660
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.43924848
26	Caffeine metabolism_Homo sapiens_hsa00232	1.41324630
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.40310937
28	Homologous recombination_Homo sapiens_hsa03440	1.29578552
29	Basal transcription factors_Homo sapiens_hsa03022	1.29061775
30	Type I diabetes mellitus_Homo sapiens_hsa04940	1.27802832
31	RNA degradation_Homo sapiens_hsa03018	1.26229599
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.25644641
33	Fat digestion and absorption_Homo sapiens_hsa04975	1.22974246
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.16809211
35	Nicotine addiction_Homo sapiens_hsa05033	1.14431701
36	Folate biosynthesis_Homo sapiens_hsa00790	1.06630690
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.06283823
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.06088537
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.05294111
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.96667030
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.94376690
42	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94137448
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.89574847
44	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.88552058
45	Retinol metabolism_Homo sapiens_hsa00830	0.88161154
46	Fanconi anemia pathway_Homo sapiens_hsa03460	0.87023755
47	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.86347142
48	Regulation of autophagy_Homo sapiens_hsa04140	0.84580619
49	Sulfur metabolism_Homo sapiens_hsa00920	0.84346427
50	Butanoate metabolism_Homo sapiens_hsa00650	0.80725538
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.79640642
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78921136
53	Purine metabolism_Homo sapiens_hsa00230	0.78327534
54	Peroxisome_Homo sapiens_hsa04146	0.75951523
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.75513247
56	Spliceosome_Homo sapiens_hsa03040	0.75362882
57	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74956288
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.72153769
59	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.72079890
60	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.69889264
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69480906
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.67728512
63	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.67649179
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67011772
65	Tryptophan metabolism_Homo sapiens_hsa00380	0.66829137
66	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.66756787
67	Metabolic pathways_Homo sapiens_hsa01100	0.66635953
68	Olfactory transduction_Homo sapiens_hsa04740	0.65681075
69	Rheumatoid arthritis_Homo sapiens_hsa05323	0.64894032
70	Antigen processing and presentation_Homo sapiens_hsa04612	0.63088902
71	Propanoate metabolism_Homo sapiens_hsa00640	0.60261566
72	Selenocompound metabolism_Homo sapiens_hsa00450	0.57511468
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.56743943
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.55663059
75	Morphine addiction_Homo sapiens_hsa05032	0.53661470
76	DNA replication_Homo sapiens_hsa03030	0.52673676
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.49862047
78	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.49802857
79	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.47983695
80	Mineral absorption_Homo sapiens_hsa04978	0.46412484
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.46275294
82	RNA transport_Homo sapiens_hsa03013	0.44024394
83	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.43904412
84	Mismatch repair_Homo sapiens_hsa03430	0.43695174
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41355235
86	Base excision repair_Homo sapiens_hsa03410	0.40610578
87	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.37374753
88	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.35450274
89	Taste transduction_Homo sapiens_hsa04742	0.34838589
90	Glutathione metabolism_Homo sapiens_hsa00480	0.33550380
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30287105
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.26932461
93	GABAergic synapse_Homo sapiens_hsa04727	0.26906442
94	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.25607782
95	Insulin secretion_Homo sapiens_hsa04911	0.24639300
96	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.23988738
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.23656627
98	Basal cell carcinoma_Homo sapiens_hsa05217	0.23559081
99	Steroid biosynthesis_Homo sapiens_hsa00100	0.22929492
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.21101155

RPL32P34

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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