RPL34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Overexpression of this gene has been observed in some cancer cells. Alternative splicing results in multiple transcript variants, all encoding the same isoform. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)9.75226489
2* cotranslational protein targeting to membrane (GO:0006613)9.62897532
3* protein targeting to ER (GO:0045047)9.59412921
4* translational elongation (GO:0006414)9.48131619
5* establishment of protein localization to endoplasmic reticulum (GO:0072599)9.18259532
6* protein localization to endoplasmic reticulum (GO:0070972)9.01039501
7* viral life cycle (GO:0019058)8.85439691
8* cellular protein complex disassembly (GO:0043624)8.78038123
9* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)8.64029790
10maturation of SSU-rRNA (GO:0030490)8.44495775
11* translational initiation (GO:0006413)7.93322139
12* protein complex disassembly (GO:0043241)7.55797248
13ribosomal large subunit biogenesis (GO:0042273)7.24273445
14* macromolecular complex disassembly (GO:0032984)7.04207666
15* protein targeting to membrane (GO:0006612)6.43629387
16* nuclear-transcribed mRNA catabolic process (GO:0000956)5.97788997
17* mRNA catabolic process (GO:0006402)5.67936848
18* translation (GO:0006412)5.63546743
19* RNA catabolic process (GO:0006401)5.15762512
20ribonucleoprotein complex biogenesis (GO:0022613)5.10119182
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.76479862
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.59536348
23ATP synthesis coupled proton transport (GO:0015986)4.59536348
24* establishment of protein localization to membrane (GO:0090150)4.35207068
25ATP biosynthetic process (GO:0006754)4.24127282
26mitochondrial respiratory chain complex assembly (GO:0033108)4.23672642
27DNA deamination (GO:0045006)4.10020226
28hydrogen ion transmembrane transport (GO:1902600)4.02320545
29cellular component biogenesis (GO:0044085)4.01055567
30* protein targeting (GO:0006605)3.97647885
31sequestering of actin monomers (GO:0042989)3.97277581
32rRNA processing (GO:0006364)3.90254215
33purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.82328210
34purine nucleoside triphosphate biosynthetic process (GO:0009145)3.81579426
35* establishment of protein localization to organelle (GO:0072594)3.80437994
36rRNA metabolic process (GO:0016072)3.73814422
37proton transport (GO:0015992)3.61668969
38formation of translation preinitiation complex (GO:0001731)3.57944330
39hydrogen transport (GO:0006818)3.55088685
40inner mitochondrial membrane organization (GO:0007007)3.42842107
41* protein localization to membrane (GO:0072657)3.39931989
42oxidative phosphorylation (GO:0006119)3.30884458
43ribonucleoside triphosphate biosynthetic process (GO:0009201)3.30718426
44protein-cofactor linkage (GO:0018065)3.21751547
45ncRNA 3-end processing (GO:0043628)3.19949597
46establishment of integrated proviral latency (GO:0075713)3.14608663
47termination of RNA polymerase III transcription (GO:0006386)3.14217432
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.14217432
49GTP biosynthetic process (GO:0006183)3.14110518
50mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.13604873
51intracellular protein transmembrane import (GO:0044743)3.09679558
52proteasome assembly (GO:0043248)2.97249375
53respiratory electron transport chain (GO:0022904)2.96075933
54tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95921047
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95921047
56UTP biosynthetic process (GO:0006228)2.93586780
57electron transport chain (GO:0022900)2.90960015
58nucleoside triphosphate biosynthetic process (GO:0009142)2.87006217
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85407780
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84621673
61cytochrome complex assembly (GO:0017004)2.84505791
62establishment of protein localization to mitochondrion (GO:0072655)2.83291019
63protein targeting to mitochondrion (GO:0006626)2.83192262
64respiratory chain complex IV assembly (GO:0008535)2.82866045
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.82086243
66regulation of mitochondrial translation (GO:0070129)2.81952723
67* cellular component disassembly (GO:0022411)2.81119214
68purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.79938993
69purine nucleoside monophosphate biosynthetic process (GO:0009127)2.79938993
70establishment of viral latency (GO:0019043)2.77633739
71aerobic respiration (GO:0009060)2.75706448
72establishment of protein localization to mitochondrial membrane (GO:0090151)2.75591608
73spliceosomal complex assembly (GO:0000245)2.75535542
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74672896
75rRNA modification (GO:0000154)2.74075131
76* protein localization to organelle (GO:0033365)2.74058239
77mitochondrial transport (GO:0006839)2.72269794
78spliceosomal snRNP assembly (GO:0000387)2.72146789
79protein localization to mitochondrion (GO:0070585)2.71596081
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.69613042
81neuron fate determination (GO:0048664)2.68426401
82antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.66661068
83chromatin remodeling at centromere (GO:0031055)2.65234677
84pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.64187749
85pseudouridine synthesis (GO:0001522)2.62385558
86organelle disassembly (GO:1903008)2.62066557
87DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.60930677
88telomere maintenance via semi-conservative replication (GO:0032201)2.60545347
89DNA damage response, detection of DNA damage (GO:0042769)2.57982912
90chaperone-mediated protein transport (GO:0072321)2.57511424
91negative regulation of ligase activity (GO:0051352)2.57012230
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.57012230
93CENP-A containing nucleosome assembly (GO:0034080)2.55993007
94intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55213185
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55213185
96deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.54153969
97UTP metabolic process (GO:0046051)2.53980211
98ncRNA processing (GO:0034470)2.52618522
99negative regulation of RNA splicing (GO:0033119)2.52117935
100CTP biosynthetic process (GO:0006241)2.50581863
101CTP metabolic process (GO:0046036)2.50581863
102signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.49893712
103signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.49893712
104signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.49893712
105DNA strand elongation involved in DNA replication (GO:0006271)2.49182722
106otic vesicle formation (GO:0030916)2.47653909
107* gene expression (GO:0010467)2.47312614
108mitochondrial respiratory chain complex I assembly (GO:0032981)2.46807046
109NADH dehydrogenase complex assembly (GO:0010257)2.46807046
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.46807046
111termination of RNA polymerase I transcription (GO:0006363)2.45030095
112signal transduction involved in DNA integrity checkpoint (GO:0072401)2.44753034
113signal transduction involved in DNA damage checkpoint (GO:0072422)2.44753034
114protein neddylation (GO:0045116)2.42663755
115transcription elongation from RNA polymerase I promoter (GO:0006362)2.42506586
116water-soluble vitamin biosynthetic process (GO:0042364)2.42051016
117positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.41577502
118signal transduction involved in cell cycle checkpoint (GO:0072395)2.41005103
119positive regulation of respiratory burst (GO:0060267)2.40206485
120pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.39766366
121behavioral response to nicotine (GO:0035095)2.39349670
122regulation of cellular amino acid metabolic process (GO:0006521)2.39098825
123epithelial cilium movement (GO:0003351)2.35744783
124histone mRNA metabolic process (GO:0008334)2.35630364
125guanosine-containing compound biosynthetic process (GO:1901070)2.34321837
126DNA strand elongation (GO:0022616)2.34245341
127regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.33460686
128platelet dense granule organization (GO:0060155)2.32440137
129pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.31335371
1307-methylguanosine mRNA capping (GO:0006370)2.29842758
131pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.28547573
132protein complex biogenesis (GO:0070271)2.28350719
133RNA capping (GO:0036260)2.28321841
1347-methylguanosine RNA capping (GO:0009452)2.28321841
135* viral transcription (GO:0019083)11.9434270
136* translational termination (GO:0006415)11.4102874
137ribosomal small subunit biogenesis (GO:0042274)11.0810957
138ribosomal small subunit assembly (GO:0000028)10.6739945

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.95822914
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.81537747
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.88918341
4* GABP_17652178_ChIP-ChIP_JURKAT_Human3.84837454
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.75072287
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.61256527
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.60945439
8E2F7_22180533_ChIP-Seq_HELA_Human3.48070302
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.33725622
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.28123518
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27809356
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03491113
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87514830
14XRN2_22483619_ChIP-Seq_HELA_Human2.85763252
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82503892
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.80700612
17* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.78203192
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74510281
19EZH2_22144423_ChIP-Seq_EOC_Human2.70286114
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55947265
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52215983
22* TTF2_22483619_ChIP-Seq_HELA_Human2.51511283
23VDR_23849224_ChIP-Seq_CD4+_Human2.50820539
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.35484512
25ELK1_19687146_ChIP-ChIP_HELA_Human2.34312514
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.26043918
27DCP1A_22483619_ChIP-Seq_HELA_Human2.19132495
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14549479
29* FOXP3_21729870_ChIP-Seq_TREG_Human2.04694349
30E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03474566
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03055774
32* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.00907667
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96175973
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88208751
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83920611
36* ELK1_22589737_ChIP-Seq_MCF10A_Human1.80088802
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77335716
38FUS_26573619_Chip-Seq_HEK293_Human1.75990032
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73091091
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71843940
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.67506087
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67483068
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66618049
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.66393475
45EWS_26573619_Chip-Seq_HEK293_Human1.64876584
46VDR_22108803_ChIP-Seq_LS180_Human1.60902357
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57945633
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54941809
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51276243
50KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.49655777
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49161405
52* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46343756
53VDR_21846776_ChIP-Seq_THP-1_Human1.45845135
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45522536
55GABP_19822575_ChIP-Seq_HepG2_Human1.44954742
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.44737120
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.42491286
58SPI1_23547873_ChIP-Seq_NB4_Human1.42329736
59* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39936354
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39652421
61* MYC_18940864_ChIP-ChIP_HL60_Human1.39120450
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.34790962
63BP1_19119308_ChIP-ChIP_Hs578T_Human1.34680663
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34650553
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33364045
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32703399
67ZNF274_21170338_ChIP-Seq_K562_Hela1.32366461
68* YY1_21170310_ChIP-Seq_MESCs_Mouse1.30554235
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27371650
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26756800
71SCL_19346495_ChIP-Seq_HPC-7_Human1.26278953
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24165528
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19926832
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19712504
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18326695
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18257398
77CIITA_25753668_ChIP-Seq_RAJI_Human1.17061412
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15003981
79IRF8_22096565_ChIP-ChIP_GC-B_Human1.09652311
80CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09247869
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.09039255
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08283406
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08199938
84NANOG_16153702_ChIP-ChIP_HESCs_Human1.06074157
85MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05384070
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04931112
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03926704
88TP53_22573176_ChIP-Seq_HFKS_Human1.03761046
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.03644491
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03091665
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02930821
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02778021
93FOXM1_23109430_ChIP-Seq_U2OS_Human1.02114223
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01642444
95MYC_22102868_ChIP-Seq_BL_Human1.01503596
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00706777
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00678031
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97780356
99MAF_26560356_Chip-Seq_TH2_Human0.97182240
100ERG_20517297_ChIP-Seq_VCAP_Human0.96891864
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95718744
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93168331
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90865180
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88188453
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87993501
106* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86943057
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86398486
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85790381
109VDR_24763502_ChIP-Seq_THP-1_Human0.85240718
110RNF2_27304074_Chip-Seq_NSC_Mouse0.84984442
111MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84970352
112FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.84302760
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83994772
114TAF15_26573619_Chip-Seq_HEK293_Human0.83780700
115STAT1_20625510_ChIP-Seq_HELA_Human0.82846885
116EZH2_27304074_Chip-Seq_ESCs_Mouse0.82272100
117SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82062895
118KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81821936
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80591359
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80472519
121FOXA1_25329375_ChIP-Seq_VCAP_Human0.80395244
122FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80395244
123UTX_26944678_Chip-Seq_JUKART_Human0.80288157
124CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79776120
125ELF5_23300383_ChIP-Seq_T47D_Human0.79042410
126AR_20517297_ChIP-Seq_VCAP_Human0.78794383
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.77955571
128MAF_26560356_Chip-Seq_TH1_Human0.77408379
129KDM5A_27292631_Chip-Seq_BREAST_Human0.77054060
130CTCF_26484167_Chip-Seq_Bcells_Mouse0.77019219
131MYB_26560356_Chip-Seq_TH2_Human0.75741969
132P300_19829295_ChIP-Seq_ESCs_Human0.73808238
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.72151356
134* IRF1_19129219_ChIP-ChIP_H3396_Human0.71937088
135CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.71741390
136FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.71396694
137TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71307213
138IGF1R_20145208_ChIP-Seq_DFB_Human0.70933213
139PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70809295
140PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70519038
141NANOG_19829295_ChIP-Seq_ESCs_Human0.68201231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.43978483
2MP0004381_abnormal_hair_follicle2.97873604
3MP0000566_synostosis2.69457332
4MP0003693_abnormal_embryo_hatching2.65323084
5MP0010030_abnormal_orbit_morphology2.62490708
6MP0005174_abnormal_tail_pigmentation2.30463859
7MP0004957_abnormal_blastocyst_morpholog2.27366354
8MP0003136_yellow_coat_color2.26758864
9MP0006072_abnormal_retinal_apoptosis2.24911837
10MP0001835_abnormal_antigen_presentation2.18536081
11MP0003763_abnormal_thymus_physiology2.13105995
12MP0003011_delayed_dark_adaptation2.09311531
13MP0004142_abnormal_muscle_tone1.98377926
14MP0009333_abnormal_splenocyte_physiolog1.94512008
15MP0005671_abnormal_response_to1.94135741
16MP0008057_abnormal_DNA_replication1.91302481
17MP0000685_abnormal_immune_system1.89075198
18MP0002148_abnormal_hypersensitivity_rea1.89060875
19MP0003880_abnormal_central_pattern1.88282577
20MP0002396_abnormal_hematopoietic_system1.86693663
21MP0002166_altered_tumor_susceptibility1.83871383
22MP0001293_anophthalmia1.81168366
23MP0001800_abnormal_humoral_immune1.80929126
24MP0002132_abnormal_respiratory_system1.80826258
25MP0002796_impaired_skin_barrier1.79880603
26MP0009785_altered_susceptibility_to1.79755279
27MP0005409_darkened_coat_color1.74480277
28MP0000490_abnormal_crypts_of1.71889675
29MP0003806_abnormal_nucleotide_metabolis1.69293183
30MP0005075_abnormal_melanosome_morpholog1.68388086
31MP0002653_abnormal_ependyma_morphology1.67311030
32MP0005000_abnormal_immune_tolerance1.64673978
33MP0005025_abnormal_response_to1.64034373
34MP0001853_heart_inflammation1.61242383
35MP0000465_gastrointestinal_hemorrhage1.58684831
36MP0003724_increased_susceptibility_to1.57374290
37MP0002420_abnormal_adaptive_immunity1.57121031
38MP0003283_abnormal_digestive_organ1.57085903
39MP0003077_abnormal_cell_cycle1.56743972
40MP0002938_white_spotting1.55926040
41MP0002095_abnormal_skin_pigmentation1.55193522
42MP0002723_abnormal_immune_serum1.55049437
43MP0002452_abnormal_antigen_presenting1.54384674
44MP0001819_abnormal_immune_cell1.53960749
45MP0000631_abnormal_neuroendocrine_gland1.53130367
46MP0002009_preneoplasia1.52537874
47MP0003941_abnormal_skin_development1.52126879
48MP0002398_abnormal_bone_marrow1.51783197
49MP0003786_premature_aging1.51079229
50MP0005084_abnormal_gallbladder_morpholo1.47808517
51MP0002006_tumorigenesis1.46573680
52MP0003436_decreased_susceptibility_to1.44676358
53MP0002163_abnormal_gland_morphology1.44495427
54MP0001485_abnormal_pinna_reflex1.44110297
55MP0010094_abnormal_chromosome_stability1.43807109
56MP0002722_abnormal_immune_system1.39176638
57MP0005501_abnormal_skin_physiology1.38558061
58MP0000372_irregular_coat_pigmentation1.37230440
59MP0002277_abnormal_respiratory_mucosa1.37039886
60MP0002102_abnormal_ear_morphology1.36998797
61MP0002405_respiratory_system_inflammati1.36362072
62MP0006054_spinal_hemorrhage1.35642590
63MP0001790_abnormal_immune_system1.34316133
64MP0005387_immune_system_phenotype1.34316133
65MP0000716_abnormal_immune_system1.33063823
66MP0003315_abnormal_perineum_morphology1.29616223
67MP0000703_abnormal_thymus_morphology1.29331223
68MP0008995_early_reproductive_senescence1.29132715
69MP0001873_stomach_inflammation1.29080580
70MP0005423_abnormal_somatic_nervous1.28631421
71MP0008877_abnormal_DNA_methylation1.28025316
72MP0008932_abnormal_embryonic_tissue1.25932439
73MP0000689_abnormal_spleen_morphology1.25827095
74MP0002429_abnormal_blood_cell1.23803946
75MP0004133_heterotaxia1.23802336
76MP0000383_abnormal_hair_follicle1.23776960
77MP0005551_abnormal_eye_electrophysiolog1.21503530
78MP0005499_abnormal_olfactory_system1.20317697
79MP0005394_taste/olfaction_phenotype1.20317697
80MP0001286_abnormal_eye_development1.19316218
81MP0010155_abnormal_intestine_physiology1.19107346
82MP0003866_abnormal_defecation1.18687365
83MP0004742_abnormal_vestibular_system1.17568857
84MP0005253_abnormal_eye_physiology1.15866067
85MP0000026_abnormal_inner_ear1.15328619
86MP0001216_abnormal_epidermal_layer1.14600485
87MP0004808_abnormal_hematopoietic_stem1.13765244
88MP0002638_abnormal_pupillary_reflex1.12970320
89MP0008058_abnormal_DNA_repair1.11029194
90MP0002098_abnormal_vibrissa_morphology1.09983976
91MP0003111_abnormal_nucleus_morphology1.07995355
92MP0006036_abnormal_mitochondrial_physio1.07293570
93MP0002234_abnormal_pharynx_morphology1.06095068
94MP0001346_abnormal_lacrimal_gland1.05776379
95MP0004885_abnormal_endolymph1.05558850
96MP0006276_abnormal_autonomic_nervous1.04279802
97MP0002822_catalepsy1.03010258
98MP0008007_abnormal_cellular_replicative1.02773973
99MP0003890_abnormal_embryonic-extraembry1.00525720
100MP0002160_abnormal_reproductive_system1.00181918
101MP0001984_abnormal_olfaction0.98175965
102MP0004145_abnormal_muscle_electrophysio0.97707864
103MP0003878_abnormal_ear_physiology0.97130176
104MP0005377_hearing/vestibular/ear_phenot0.97130176
105MP0002060_abnormal_skin_morphology0.96020405
106MP0000778_abnormal_nervous_system0.95945638
107MP0005397_hematopoietic_system_phenotyp0.95894027
108MP0001545_abnormal_hematopoietic_system0.95894027
109MP0005645_abnormal_hypothalamus_physiol0.95662416
110MP0001727_abnormal_embryo_implantation0.95635799
111MP0005195_abnormal_posterior_eye0.94842171
112MP0002419_abnormal_innate_immunity0.94405226
113MP0008789_abnormal_olfactory_epithelium0.92965210
114MP0002736_abnormal_nociception_after0.92443183
115MP0004947_skin_inflammation0.91543013
116MP0003938_abnormal_ear_development0.91090837
117MP0003121_genomic_imprinting0.90891109
118MP0000858_altered_metastatic_potential0.90478073
119MP0005646_abnormal_pituitary_gland0.90418701
120MP0003787_abnormal_imprinting0.90329955
121MP0005379_endocrine/exocrine_gland_phen0.89823343
122MP0005408_hypopigmentation0.89448522
123MP0005464_abnormal_platelet_physiology0.89183896
124MP0008875_abnormal_xenobiotic_pharmacok0.87687591
125MP0002019_abnormal_tumor_incidence0.87441715
126MP0002254_reproductive_system_inflammat0.87227977
127MP0002752_abnormal_somatic_nervous0.86567543
128MP0005389_reproductive_system_phenotype0.86402337
129MP0002282_abnormal_trachea_morphology0.85951305
130MP0008872_abnormal_physiological_respon0.85754265
131MP0001986_abnormal_taste_sensitivity0.85553710
132MP0010771_integument_phenotype0.85509666
133MP0001851_eye_inflammation0.85296218
134MP0002210_abnormal_sex_determination0.85290929
135MP0002928_abnormal_bile_duct0.85103819
136MP0006292_abnormal_olfactory_placode0.84876292
137MP0001905_abnormal_dopamine_level0.84868431
138MP0005391_vision/eye_phenotype0.83872437
139MP0001845_abnormal_inflammatory_respons0.83650102
140MP0002272_abnormal_nervous_system0.83465472
141MP0002751_abnormal_autonomic_nervous0.83452872
142MP0002933_joint_inflammation0.82719221
143MP0001968_abnormal_touch/_nociception0.81484965
144MP0000049_abnormal_middle_ear0.80924665
145MP0001529_abnormal_vocalization0.79591945
146MP0008961_abnormal_basal_metabolism0.79565387
147MP0009745_abnormal_behavioral_response0.78146499
148MP0009931_abnormal_skin_appearance0.77662509
149MP0003567_abnormal_fetal_cardiomyocyte0.77002408
150MP0003718_maternal_effect0.76496178
151MP0001919_abnormal_reproductive_system0.75931401
152MP0006035_abnormal_mitochondrial_morpho0.75509455
153MP0000377_abnormal_hair_follicle0.75000425
154MP0001324_abnormal_eye_pigmentation0.74914721
155MP0002233_abnormal_nose_morphology0.74780779
156MP0000762_abnormal_tongue_morphology0.74488285
157MP0003186_abnormal_redox_activity0.74328532
158MP0002697_abnormal_eye_size0.73850926
159MP0010386_abnormal_urinary_bladder0.73526035
160MP0002837_dystrophic_cardiac_calcinosis0.73082212
161MP0003937_abnormal_limbs/digits/tail_de0.72806692
162MP0001764_abnormal_homeostasis0.71721237
163MP0001963_abnormal_hearing_physiology0.70160643
164MP0009250_abnormal_appendicular_skeleto0.69532572
165MP0004147_increased_porphyrin_level0.67309188
166MP0002557_abnormal_social/conspecific_i0.66968371

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)9.54177318
2Reticulocytopenia (HP:0001896)8.72439993
3Macrocytic anemia (HP:0001972)6.97785743
4Pallor (HP:0000980)6.49081413
5Increased hepatocellular lipid droplets (HP:0006565)3.83572416
6Acute necrotizing encephalopathy (HP:0006965)3.64872042
7Aplasia/Hypoplasia of the sacrum (HP:0008517)3.58077993
8Mitochondrial inheritance (HP:0001427)3.53018738
9Congenital, generalized hypertrichosis (HP:0004540)3.45476908
10Thrombocytosis (HP:0001894)3.32840383
11Abnormal hemoglobin (HP:0011902)3.32250577
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.26631057
13Lipid accumulation in hepatocytes (HP:0006561)3.24899691
14Renal Fanconi syndrome (HP:0001994)3.20474774
15Exertional dyspnea (HP:0002875)3.17959615
16Abnormality of secondary sexual hair (HP:0009888)3.16153053
17Abnormality of the axillary hair (HP:0100134)3.16153053
18Septo-optic dysplasia (HP:0100842)3.13562325
19Abnormal mitochondria in muscle tissue (HP:0008316)3.13413778
20Stenosis of the external auditory canal (HP:0000402)3.07702810
21Progressive macrocephaly (HP:0004481)2.97354765
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.91204578
23Depressed nasal ridge (HP:0000457)2.88988098
243-Methylglutaconic aciduria (HP:0003535)2.87920852
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87154656
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87154656
27Parakeratosis (HP:0001036)2.87005106
28Aplastic anemia (HP:0001915)2.85245021
29Hepatocellular necrosis (HP:0001404)2.84718196
30Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.82329548
31Pancreatic cysts (HP:0001737)2.81297324
32Increased CSF lactate (HP:0002490)2.77529650
33Abnormality of reticulocytes (HP:0004312)2.75756565
3411 pairs of ribs (HP:0000878)2.75502084
35Molar tooth sign on MRI (HP:0002419)2.72222336
36Abnormality of midbrain morphology (HP:0002418)2.72222336
37Migraine (HP:0002076)2.69479435
38Acute encephalopathy (HP:0006846)2.68758706
39Pancreatic fibrosis (HP:0100732)2.68353140
40Respiratory difficulties (HP:0002880)2.65025510
41Elevated erythrocyte sedimentation rate (HP:0003565)2.64697590
42IgM deficiency (HP:0002850)2.63676797
43Increased intramyocellular lipid droplets (HP:0012240)2.59767901
44True hermaphroditism (HP:0010459)2.59646113
45Nephronophthisis (HP:0000090)2.52863834
46Absent thumb (HP:0009777)2.51929394
47Chronic otitis media (HP:0000389)2.50357866
48Woolly hair (HP:0002224)2.47483207
49Colon cancer (HP:0003003)2.43632353
50Glycosuria (HP:0003076)2.31631886
51Abnormality of urine glucose concentration (HP:0011016)2.31631886
52Thick lower lip vermilion (HP:0000179)2.28494233
53Hyperphosphaturia (HP:0003109)2.27812262
54Medial flaring of the eyebrow (HP:0010747)2.26722860
55Asplenia (HP:0001746)2.25856117
56Hepatic necrosis (HP:0002605)2.24206078
57Concave nail (HP:0001598)2.20693497
58Abnormality of the parietal bone (HP:0002696)2.18642376
59Petechiae (HP:0000967)2.18271425
60Partial duplication of thumb phalanx (HP:0009944)2.15836066
61Absent septum pellucidum (HP:0001331)2.13823064
62Congenital ichthyosiform erythroderma (HP:0007431)2.13201404
63Trismus (HP:0000211)2.10569061
64Rib fusion (HP:0000902)2.09469937
65Increased muscle lipid content (HP:0009058)2.05391150
66Type I transferrin isoform profile (HP:0003642)2.04472763
67Hypoplasia of the radius (HP:0002984)2.03859203
68Exercise intolerance (HP:0003546)2.03724126
69Methylmalonic acidemia (HP:0002912)2.02911467
70Fragile nails (HP:0001808)2.02172210
71Aplasia/Hypoplasia of the spleen (HP:0010451)2.01285506
72Abnormality of cells of the erythroid lineage (HP:0012130)10.8718346
73Sclerocornea (HP:0000647)1.99008104
74Partial duplication of the phalanx of hand (HP:0009999)1.97092219
75Myokymia (HP:0002411)1.96716834
76Abnormality of the phalanges of the 2nd finger (HP:0009541)1.96229813
77Triphalangeal thumb (HP:0001199)1.95937202
78Abnormality of the renal medulla (HP:0100957)1.95486731
79Recurrent bronchitis (HP:0002837)1.92945627
80Hypoproteinemia (HP:0003075)1.92039626
81Multiple enchondromatosis (HP:0005701)1.89909328
82Panhypogammaglobulinemia (HP:0003139)1.88933509
83Abnormal respiratory motile cilium physiology (HP:0012261)1.87944118
84Glossoptosis (HP:0000162)1.87806147
85Hypotrichosis (HP:0001006)1.87761045
86Oral leukoplakia (HP:0002745)1.87323328
87Lethargy (HP:0001254)1.86272346
88Maternal diabetes (HP:0009800)1.85322379
89Esophageal atresia (HP:0002032)1.84887595
90Abnormality of placental membranes (HP:0011409)1.84042918
91Amniotic constriction ring (HP:0009775)1.84042918
92Sparse eyelashes (HP:0000653)1.83910863
93Rhinitis (HP:0012384)1.83875621
94Increased serum lactate (HP:0002151)1.82501452
95Abnormal ciliary motility (HP:0012262)1.82000485
96Abnormality of renal resorption (HP:0011038)1.81594690
97Respiratory failure (HP:0002878)1.81163211
98Chronic sinusitis (HP:0011109)1.81135564
99Bilateral microphthalmos (HP:0007633)1.80652636
100Congenital primary aphakia (HP:0007707)1.79224718
101Optic disc pallor (HP:0000543)1.78688353
102Abnormality of the septum pellucidum (HP:0007375)1.77632869
103Cleft eyelid (HP:0000625)1.77446997
104Gait imbalance (HP:0002141)1.77430628
105Abnormality of the labia minora (HP:0012880)1.76617014
106Aplasia cutis congenita (HP:0001057)1.75541198
107Hypoplasia of the pons (HP:0012110)1.74262338
108Abnormality of the pons (HP:0007361)1.73068952
109Anophthalmia (HP:0000528)1.72884809
110Abnormal urine phosphate concentration (HP:0012599)1.71649778
111Male pseudohermaphroditism (HP:0000037)1.71496655
112Congenital stationary night blindness (HP:0007642)1.71271710
113Erythema (HP:0010783)1.71061425
114Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.68005150
115Optic nerve hypoplasia (HP:0000609)1.67281177
116Muscle fiber atrophy (HP:0100295)1.67273261
117Rough bone trabeculation (HP:0100670)1.67217644
118Methylmalonic aciduria (HP:0012120)1.67041777
119Abnormality of the heme biosynthetic pathway (HP:0010472)1.66756796
120IgG deficiency (HP:0004315)1.64832721
121Abnormal respiratory epithelium morphology (HP:0012253)1.64730911
122Abnormal respiratory motile cilium morphology (HP:0005938)1.64730911
123Nasolacrimal duct obstruction (HP:0000579)1.64227333
124Abnormality of aspartate family amino acid metabolism (HP:0010899)1.63007893
125Poikiloderma (HP:0001029)1.62781405
126Onycholysis (HP:0001806)1.62095242
127Nephrogenic diabetes insipidus (HP:0009806)1.62031870
128Vaginal atresia (HP:0000148)1.61801264
129Absent rod-and cone-mediated responses on ERG (HP:0007688)1.60687691
130Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60176302
131Agammaglobulinemia (HP:0004432)1.60134655
132Microretrognathia (HP:0000308)1.59910950
133Anencephaly (HP:0002323)1.59452712
134Nasal polyposis (HP:0100582)1.58621578
135Pancytopenia (HP:0001876)1.58480507
136Lactic acidosis (HP:0003128)1.57350287
137Ridged nail (HP:0001807)1.55505472
138Seborrheic dermatitis (HP:0001051)1.55208808
139Recurrent abscess formation (HP:0002722)1.54158580
140Septate vagina (HP:0001153)1.53918627
141Leukodystrophy (HP:0002415)1.53702582
142Myositis (HP:0100614)1.52950943
143Pustule (HP:0200039)1.52619773
144Cerebral edema (HP:0002181)1.52226686
145Breast hypoplasia (HP:0003187)1.51374051
146Anhidrosis (HP:0000970)1.50865288
147Duplication of thumb phalanx (HP:0009942)1.50371909

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.66393258
2VRK25.07914419
3STK163.18907161
4MST43.07834186
5ZAK2.99053522
6TLK12.67337229
7BUB12.55272882
8LRRK22.49474420
9PIM22.49163458
10RPS6KB22.34140676
11VRK12.33499874
12MAP4K12.19925826
13WEE12.19292216
14SRPK11.99200527
15NUAK11.95845480
16TGFBR11.95372523
17DYRK31.91689186
18CDK191.86582836
19TAF11.83452466
20PNCK1.78526774
21BLK1.70859265
22KDR1.67975697
23EEF2K1.59007577
24NME11.55280997
25TEC1.43619385
26BTK1.43290085
27BCKDK1.43201238
28WNK31.36551705
29TAOK31.34160438
30KIT1.32501423
31EIF2AK31.29904327
32MAP3K41.29643174
33ILK1.29436412
34MAP4K21.24657097
35IKBKB1.22273273
36IRAK41.21203035
37MUSK1.21099300
38PASK1.19818407
39TYK21.19400524
40ACVR1B1.16227296
41TNIK1.14390717
42MAPKAPK31.14070554
43GRK71.13342739
44MAPKAPK51.12983300
45MKNK11.12632765
46INSRR1.10609041
47SYK1.09476965
48GRK61.08331620
49RPS6KA41.07098153
50NLK1.05094079
51MAP3K31.04044063
52EIF2AK11.03648374
53PBK1.00437020
54MAP2K70.96321506
55AURKB0.96176345
56RPS6KA50.95771381
57TESK20.95634531
58FGFR20.94995734
59WNK40.93687867
60PLK40.92483838
61MAP2K20.91972525
62PINK10.91073684
63BMPR1B0.90243289
64PLK30.87825019
65OXSR10.87166021
66CDK70.86708526
67TXK0.85744470
68MAP3K120.85459162
69ADRBK20.84969938
70IKBKE0.84683010
71ZAP700.81590478
72CDK30.81442301
73PIM10.79812315
74IRAK30.79340322
75TBK10.79281236
76LYN0.79091279
77CSNK2A20.76918362
78TGFBR20.76040340
79LCK0.75702678
80STK100.74685999
81DYRK20.73609108
82ITK0.73588964
83EIF2AK20.71898778
84CSF1R0.69742250
85FLT30.69702164
86CHEK20.69574594
87PRKCG0.68843955
88GRK10.67726997
89AURKA0.65364054
90CDC70.64175456
91CSNK2A10.64103865
92FES0.63643014
93MYLK0.63592180
94MST1R0.63011547
95MAP3K110.62692384
96MAPK40.62550302
97NEK20.61918872
98MAPK150.60969569
99CDK80.59391584
100JAK30.58539811
101TSSK60.54442361
102YES10.52970795
103MAP2K30.52545764
104NTRK20.52491352
105CLK10.50959875
106ADRBK10.50959118
107MKNK20.50537054
108ATR0.48832133
109DAPK30.48761756
110MAPK130.48239317
111BRSK20.47879537
112CSNK1G30.45566368
113MATK0.45536499
114ABL20.44855735
115CAMKK20.44360761
116PRKCQ0.44211191
117PAK10.44189482
118MAP2K40.44033493
119PIK3CG0.42938111
120CCNB10.41794238
121MAPKAPK20.41255534
122DYRK1B0.40900560
123PAK20.40887906
124PRKACA0.40669599
125EPHA40.39634224
126PRKCD0.38043577
127FGR0.38041756
128TIE10.37816264
129PIK3CA0.37704668
130CASK0.37428540
131TTK0.36785078
132MAP3K100.36287600
133MAPK70.35625283
134MOS0.35523463
135CSNK1E0.35267521
136EPHB20.35010238
137PLK10.34889132
138PRKG10.33648781
139STK240.33586867
140CAMK10.32477955
141UHMK10.32290991
142PHKG20.31176495
143PHKG10.31176495

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030109.04602328
2Proteasome_Homo sapiens_hsa030503.40473219
3RNA polymerase_Homo sapiens_hsa030203.15618639
4Oxidative phosphorylation_Homo sapiens_hsa001903.08157647
5Parkinsons disease_Homo sapiens_hsa050122.72320215
6DNA replication_Homo sapiens_hsa030302.71444296
7Spliceosome_Homo sapiens_hsa030402.57577151
8Protein export_Homo sapiens_hsa030602.37819209
9Mismatch repair_Homo sapiens_hsa034302.21403145
10Pyrimidine metabolism_Homo sapiens_hsa002402.02251359
11Huntingtons disease_Homo sapiens_hsa050162.01437523
12Alzheimers disease_Homo sapiens_hsa050101.95836347
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.86126493
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84686013
15Homologous recombination_Homo sapiens_hsa034401.80704964
16Nucleotide excision repair_Homo sapiens_hsa034201.80477412
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75213068
18Primary immunodeficiency_Homo sapiens_hsa053401.67743402
19Base excision repair_Homo sapiens_hsa034101.57644616
20RNA transport_Homo sapiens_hsa030131.34534987
21RNA degradation_Homo sapiens_hsa030181.19316320
22Non-homologous end-joining_Homo sapiens_hsa034501.18933983
23Basal transcription factors_Homo sapiens_hsa030221.14687935
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14286462
25Fanconi anemia pathway_Homo sapiens_hsa034601.09405832
26Systemic lupus erythematosus_Homo sapiens_hsa053221.00159397
27Hematopoietic cell lineage_Homo sapiens_hsa046400.98429717
28Purine metabolism_Homo sapiens_hsa002300.96093351
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93213425
30Antigen processing and presentation_Homo sapiens_hsa046120.91172997
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89450597
32Sulfur relay system_Homo sapiens_hsa041220.88421850
33Intestinal immune network for IgA production_Homo sapiens_hsa046720.87190013
34p53 signaling pathway_Homo sapiens_hsa041150.85678963
35Allograft rejection_Homo sapiens_hsa053300.83605090
36Epstein-Barr virus infection_Homo sapiens_hsa051690.83507354
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81073820
38Collecting duct acid secretion_Homo sapiens_hsa049660.79939251
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.79787552
40Phototransduction_Homo sapiens_hsa047440.79429699
41Graft-versus-host disease_Homo sapiens_hsa053320.78390966
42Chemical carcinogenesis_Homo sapiens_hsa052040.77884846
43Maturity onset diabetes of the young_Homo sapiens_hsa049500.77794189
44Asthma_Homo sapiens_hsa053100.74444219
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72772186
46Cell cycle_Homo sapiens_hsa041100.72764642
47Herpes simplex infection_Homo sapiens_hsa051680.72128747
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70217961
49Arachidonic acid metabolism_Homo sapiens_hsa005900.69794485
50Cardiac muscle contraction_Homo sapiens_hsa042600.69631673
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.68913844
52Vitamin digestion and absorption_Homo sapiens_hsa049770.65945840
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65807502
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64979763
55One carbon pool by folate_Homo sapiens_hsa006700.64015496
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63285667
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62671183
58Nitrogen metabolism_Homo sapiens_hsa009100.62409606
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60848665
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60109487
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58354902
62Glutathione metabolism_Homo sapiens_hsa004800.57747723
63Folate biosynthesis_Homo sapiens_hsa007900.57388749
64Peroxisome_Homo sapiens_hsa041460.56338554
65Measles_Homo sapiens_hsa051620.55689066
66Autoimmune thyroid disease_Homo sapiens_hsa053200.54741997
67Butanoate metabolism_Homo sapiens_hsa006500.54630374
68Propanoate metabolism_Homo sapiens_hsa006400.52385783
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50939226
70Nicotine addiction_Homo sapiens_hsa050330.50689494
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50148639
72Regulation of autophagy_Homo sapiens_hsa041400.48928882
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48812181
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48802753
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48682747
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.48106459
77B cell receptor signaling pathway_Homo sapiens_hsa046620.47752501
78Tryptophan metabolism_Homo sapiens_hsa003800.46853471
79Retinol metabolism_Homo sapiens_hsa008300.46097575
80Type I diabetes mellitus_Homo sapiens_hsa049400.45979569
81Linoleic acid metabolism_Homo sapiens_hsa005910.45288362
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44853112
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44827452
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44708606
85Sphingolipid metabolism_Homo sapiens_hsa006000.44552840
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.44497857
87Caffeine metabolism_Homo sapiens_hsa002320.44124869
88Leishmaniasis_Homo sapiens_hsa051400.44023812
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43484944
90T cell receptor signaling pathway_Homo sapiens_hsa046600.43050783
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42757750
92Alcoholism_Homo sapiens_hsa050340.42728954
93Viral carcinogenesis_Homo sapiens_hsa052030.40331956
94mRNA surveillance pathway_Homo sapiens_hsa030150.40010404
95Hedgehog signaling pathway_Homo sapiens_hsa043400.39060910
96N-Glycan biosynthesis_Homo sapiens_hsa005100.38271595
97HTLV-I infection_Homo sapiens_hsa051660.38226053
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.37035418
99Pyruvate metabolism_Homo sapiens_hsa006200.36441187
100Apoptosis_Homo sapiens_hsa042100.36033208
101Malaria_Homo sapiens_hsa051440.35913566
102Selenocompound metabolism_Homo sapiens_hsa004500.35213809
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.34812752
104Pertussis_Homo sapiens_hsa051330.34348234
105Legionellosis_Homo sapiens_hsa051340.33330983
106Metabolic pathways_Homo sapiens_hsa011000.32493985
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32357082
108Taste transduction_Homo sapiens_hsa047420.31808607
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29816854
110Olfactory transduction_Homo sapiens_hsa047400.28279584
111Shigellosis_Homo sapiens_hsa051310.28097008
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.28037926
113Notch signaling pathway_Homo sapiens_hsa043300.27909580
114Mineral absorption_Homo sapiens_hsa049780.27792733
115Ether lipid metabolism_Homo sapiens_hsa005650.27653968
116Other glycan degradation_Homo sapiens_hsa005110.26562748
117Rheumatoid arthritis_Homo sapiens_hsa053230.26176264
118Pentose phosphate pathway_Homo sapiens_hsa000300.25474758
119Tyrosine metabolism_Homo sapiens_hsa003500.23779034
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23270657
121Basal cell carcinoma_Homo sapiens_hsa052170.22823252
122Small cell lung cancer_Homo sapiens_hsa052220.21980507
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20916041
124Hepatitis B_Homo sapiens_hsa051610.20903364
125Osteoclast differentiation_Homo sapiens_hsa043800.20194225
126Platelet activation_Homo sapiens_hsa046110.19964877
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19346791
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19126905
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.18832726
130Acute myeloid leukemia_Homo sapiens_hsa052210.18352390
131Toxoplasmosis_Homo sapiens_hsa051450.17488386
132Fatty acid elongation_Homo sapiens_hsa000620.17151615
133Fat digestion and absorption_Homo sapiens_hsa049750.17042041
134Pathways in cancer_Homo sapiens_hsa052000.16592489
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.15529306
136Thyroid cancer_Homo sapiens_hsa052160.14945133
137Sulfur metabolism_Homo sapiens_hsa009200.13942745
138Influenza A_Homo sapiens_hsa051640.13914691
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12044448
140Wnt signaling pathway_Homo sapiens_hsa043100.11169727
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.10708806
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10471960

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