ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.80661333
2	ribosomal small subunit assembly (GO:0000028)	6.10089098
3	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.64501952
4	cytidine catabolic process (GO:0006216)	5.46505342
5	cytidine deamination (GO:0009972)	5.46505342
6	cytidine metabolic process (GO:0046087)	5.46505342
7	viral transcription (GO:0019083)	4.88630881
8	maturation of SSU-rRNA (GO:0030490)	4.86439991
9	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.86181697
10	translational termination (GO:0006415)	4.65949590
11	ATP synthesis coupled proton transport (GO:0015986)	4.50945307
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.50945307
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.35594578
14	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.31313225
15	translational elongation (GO:0006414)	4.17659758
16	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.11762028
17	cotranslational protein targeting to membrane (GO:0006613)	4.05278633
18	protein targeting to ER (GO:0045047)	4.04088398
19	respiratory electron transport chain (GO:0022904)	3.93249023
20	electron transport chain (GO:0022900)	3.91591164
21	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.85826428
22	protein localization to endoplasmic reticulum (GO:0070972)	3.82434329
23	positive thymic T cell selection (GO:0045059)	3.64940615
24	protein neddylation (GO:0045116)	3.57304740
25	ribosomal small subunit biogenesis (GO:0042274)	3.53299555
26	positive T cell selection (GO:0043368)	3.52246070
27	protein complex biogenesis (GO:0070271)	3.49188232
28	viral life cycle (GO:0019058)	3.48632672
29	cellular protein complex disassembly (GO:0043624)	3.47577087
30	behavioral response to nicotine (GO:0035095)	3.44761174
31	sequestering of actin monomers (GO:0042989)	3.29023297
32	positive regulation of calcium-mediated signaling (GO:0050850)	3.27334354
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.24944582
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.24944582
35	NADH dehydrogenase complex assembly (GO:0010257)	3.24944582
36	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.21547323
37	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.16403620
38	negative T cell selection (GO:0043383)	3.11250662
39	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.09357768
40	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.07049744
41	T cell migration (GO:0072678)	3.05660491
42	mitochondrial respiratory chain complex assembly (GO:0033108)	3.04398302
43	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.04100171
44	response to interferon-beta (GO:0035456)	3.00616241
45	piRNA metabolic process (GO:0034587)	2.98631631
46	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.97225367
47	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.97225367
48	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.96623292
49	actin nucleation (GO:0045010)	2.93840365
50	translational initiation (GO:0006413)	2.90985497
51	negative regulation of T cell apoptotic process (GO:0070233)	2.90668481
52	positive regulation of prostaglandin secretion (GO:0032308)	2.89095916
53	translation (GO:0006412)	2.89076617
54	hydrogen ion transmembrane transport (GO:1902600)	2.88916350
55	negative regulation by host of viral transcription (GO:0043922)	2.88843173
56	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.88060744
57	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.87705338
58	rRNA catabolic process (GO:0016075)	2.87645527
59	platelet dense granule organization (GO:0060155)	2.87227476
60	respiratory chain complex IV assembly (GO:0008535)	2.83971948
61	tryptophan catabolic process (GO:0006569)	2.83110365
62	indole-containing compound catabolic process (GO:0042436)	2.83110365
63	indolalkylamine catabolic process (GO:0046218)	2.83110365
64	cytochrome complex assembly (GO:0017004)	2.82794516
65	base-excision repair, AP site formation (GO:0006285)	2.81861710
66	positive regulation of T cell apoptotic process (GO:0070234)	2.80677945
67	protein complex disassembly (GO:0043241)	2.78783488
68	proton transport (GO:0015992)	2.77816521
69	ribosomal large subunit biogenesis (GO:0042273)	2.76099524
70	regulation of regulatory T cell differentiation (GO:0045589)	2.75039204
71	hydrogen transport (GO:0006818)	2.72476866
72	macromolecular complex disassembly (GO:0032984)	2.71095373
73	positive regulation of fatty acid transport (GO:2000193)	2.69263129
74	interferon-gamma production (GO:0032609)	2.67300483
75	sulfation (GO:0051923)	2.65934469
76	iron-sulfur cluster assembly (GO:0016226)	2.65478041
77	metallo-sulfur cluster assembly (GO:0031163)	2.65478041
78	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.64659731
79	thymic T cell selection (GO:0045061)	2.64321147
80	cellular response to interleukin-15 (GO:0071350)	2.64142598
81	water-soluble vitamin biosynthetic process (GO:0042364)	2.63082968
82	chaperone-mediated protein transport (GO:0072321)	2.63044329
83	kynurenine metabolic process (GO:0070189)	2.61865523
84	regulation of B cell receptor signaling pathway (GO:0050855)	2.60841612
85	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.60816433
86	ATP biosynthetic process (GO:0006754)	2.59913929
87	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.59732669
88	regulation of cellular amino acid metabolic process (GO:0006521)	2.59719872
89	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.59706468
90	axoneme assembly (GO:0035082)	2.59503709
91	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.59086159
92	protein targeting to membrane (GO:0006612)	2.58910473
93	indolalkylamine metabolic process (GO:0006586)	2.58526323
94	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.57771892
95	pyrimidine nucleoside catabolic process (GO:0046135)	2.56855496
96	positive regulation of defense response to virus by host (GO:0002230)	2.54539052
97	negative regulation of mast cell activation (GO:0033004)	2.54511578
98	positive regulation of cell killing (GO:0031343)	2.54332384
99	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.51600742
100	negative regulation of telomere maintenance (GO:0032205)	2.50929044

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.49029814
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.78723757
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.09097567
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.00769499
5	VDR_22108803_ChIP-Seq_LS180_Human	2.95197288
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.73642433
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.57885086
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.57011135
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.54617629
10	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.54084762
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.44161114
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.41681386
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.39766039
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.36697045
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.15584724
16	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.09158670
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.89521996
18	VDR_23849224_ChIP-Seq_CD4+_Human	1.85423850
19	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.84316028
20	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.82899879
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.77162529
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.73621948
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.66505002
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.65655713
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61931828
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.60378011
27	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.55839953
28	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.52641451
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.52587849
30	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.45874541
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.45448699
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.40864800
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.40152505
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.38640697
35	AR_20517297_ChIP-Seq_VCAP_Human	1.37975506
36	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.35477507
37	TAF2_19829295_ChIP-Seq_ESCs_Human	1.33037732
38	NANOG_20526341_ChIP-Seq_ESCs_Human	1.32915683
39	ELK1_19687146_ChIP-ChIP_HELA_Human	1.32464704
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.31818034
41	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31712295
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.31567861
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30762356
44	GATA3_26560356_Chip-Seq_TH2_Human	1.30549692
45	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.29138154
46	EWS_26573619_Chip-Seq_HEK293_Human	1.28530368
47	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.28149751
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27344288
49	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.26467863
50	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.25031286
51	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.24396348
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24282522
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24282522
54	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.24198806
55	NCOR_22424771_ChIP-Seq_293T_Human	1.22272996
56	ER_23166858_ChIP-Seq_MCF-7_Human	1.22154834
57	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.21144365
58	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.19635147
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18170094
60	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.17487696
61	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.16526792
62	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15564639
63	RUNX_20019798_ChIP-Seq_JUKART_Human	1.13644043
64	MYB_26560356_Chip-Seq_TH2_Human	1.13615976
65	BCL6_27268052_Chip-Seq_Bcells_Human	1.12970782
66	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10627355
67	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.09715711
68	ERG_20517297_ChIP-Seq_VCAP_Human	1.09272803
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08674778
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08674778
71	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.07910797
72	GATA3_27048872_Chip-Seq_THYMUS_Human	1.06387927
73	MYC_19829295_ChIP-Seq_ESCs_Human	1.05177692
74	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.04432175
75	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03795288
76	ERA_21632823_ChIP-Seq_H3396_Human	1.03749973
77	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03030176
78	CTCF_20526341_ChIP-Seq_ESCs_Human	1.02663480
79	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.02130381
80	FUS_26573619_Chip-Seq_HEK293_Human	1.01708775
81	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.01682457
82	P53_21459846_ChIP-Seq_SAOS-2_Human	1.00508874
83	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99972561
84	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.98893963
85	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.98871528
86	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98613330
87	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.97389476
88	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.96837773
89	P300_27268052_Chip-Seq_Bcells_Human	0.96776451
90	P300_19829295_ChIP-Seq_ESCs_Human	0.95884723
91	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.95580385
92	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.93345822
93	E2F1_20622854_ChIP-Seq_HELA_Human	0.93322987
94	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.92729208
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.92438129
96	CBP_20019798_ChIP-Seq_JUKART_Human	0.90626064
97	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.90626064
98	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.89795752
99	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.88483024
100	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.88218384

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.48158143
2	MP0009379_abnormal_foot_pigmentation	3.30202884
3	MP0002102_abnormal_ear_morphology	2.38323044
4	MP0003646_muscle_fatigue	2.27098077
5	MP0005646_abnormal_pituitary_gland	2.13641637
6	MP0006292_abnormal_olfactory_placode	2.11283439
7	MP0009785_altered_susceptibility_to	2.07157251
8	MP0001835_abnormal_antigen_presentation	2.02813951
9	MP0005645_abnormal_hypothalamus_physiol	2.01812625
10	MP0002163_abnormal_gland_morphology	1.99198520
11	MP0006072_abnormal_retinal_apoptosis	1.94092665
12	MP0004147_increased_porphyrin_level	1.79262131
13	MP0008872_abnormal_physiological_respon	1.76145030
14	MP0005551_abnormal_eye_electrophysiolog	1.75456379
15	MP0000685_abnormal_immune_system	1.75381021
16	MP0001800_abnormal_humoral_immune	1.70965063
17	MP0001905_abnormal_dopamine_level	1.68131552
18	MP0003878_abnormal_ear_physiology	1.65450408
19	MP0005377_hearing/vestibular/ear_phenot	1.65450408
20	MP0005387_immune_system_phenotype	1.65276864
21	MP0001790_abnormal_immune_system	1.65276864
22	MP0002876_abnormal_thyroid_physiology	1.65180820
23	MP0004145_abnormal_muscle_electrophysio	1.64637572
24	MP0006276_abnormal_autonomic_nervous	1.64348023
25	MP0003880_abnormal_central_pattern	1.63357837
26	MP0008877_abnormal_DNA_methylation	1.63096570
27	MP0003787_abnormal_imprinting	1.62491178
28	MP0002138_abnormal_hepatobiliary_system	1.62324614
29	MP0004142_abnormal_muscle_tone	1.62253002
30	MP0008789_abnormal_olfactory_epithelium	1.62164589
31	MP0008875_abnormal_xenobiotic_pharmacok	1.57496357
32	MP0009333_abnormal_splenocyte_physiolog	1.56417906
33	MP0001968_abnormal_touch/_nociception	1.55253757
34	MP0004885_abnormal_endolymph	1.54719504
35	MP0001986_abnormal_taste_sensitivity	1.54703546
36	MP0005000_abnormal_immune_tolerance	1.53869904
37	MP0002148_abnormal_hypersensitivity_rea	1.49984741
38	MP0005075_abnormal_melanosome_morpholog	1.49376185
39	MP0002723_abnormal_immune_serum	1.44704059
40	MP0002095_abnormal_skin_pigmentation	1.44502498
41	MP0002638_abnormal_pupillary_reflex	1.44012126
42	MP0008995_early_reproductive_senescence	1.41274668
43	MP0002420_abnormal_adaptive_immunity	1.37909691
44	MP0003763_abnormal_thymus_physiology	1.37478217
45	MP0002234_abnormal_pharynx_morphology	1.37244075
46	MP0003866_abnormal_defecation	1.35925054
47	MP0001819_abnormal_immune_cell	1.32948372
48	MP0002736_abnormal_nociception_after	1.32105612
49	MP0005025_abnormal_response_to	1.31210671
50	MP0001485_abnormal_pinna_reflex	1.30213150
51	MP0001984_abnormal_olfaction	1.30148902
52	MP0002837_dystrophic_cardiac_calcinosis	1.29063067
53	MP0002277_abnormal_respiratory_mucosa	1.28542168
54	MP0000372_irregular_coat_pigmentation	1.27297822
55	MP0005389_reproductive_system_phenotype	1.26769092
56	MP0001919_abnormal_reproductive_system	1.25041379
57	MP0003195_calcinosis	1.23934291
58	MP0005379_endocrine/exocrine_gland_phen	1.21670061
59	MP0004742_abnormal_vestibular_system	1.15140969
60	MP0002160_abnormal_reproductive_system	1.14791539
61	MP0002452_abnormal_antigen_presenting	1.14740393
62	MP0001529_abnormal_vocalization	1.13715523
63	MP0002272_abnormal_nervous_system	1.13194715
64	MP0009764_decreased_sensitivity_to	1.12405985
65	MP0005253_abnormal_eye_physiology	1.09987097
66	MP0005394_taste/olfaction_phenotype	1.06033093
67	MP0005499_abnormal_olfactory_system	1.06033093
68	MP0009046_muscle_twitch	1.04723162
69	MP0005084_abnormal_gallbladder_morpholo	1.04711188
70	MP0009745_abnormal_behavioral_response	1.04111705
71	MP0000716_abnormal_immune_system	1.02559190
72	MP0003011_delayed_dark_adaptation	1.01008689
73	MP0001873_stomach_inflammation	0.96619068
74	MP0002653_abnormal_ependyma_morphology	0.96101520
75	MP0002398_abnormal_bone_marrow	0.94806619
76	MP0001970_abnormal_pain_threshold	0.89466151
77	MP0001764_abnormal_homeostasis	0.89190707
78	MP0001501_abnormal_sleep_pattern	0.88179646
79	MP0006082_CNS_inflammation	0.87314188
80	MP0000631_abnormal_neuroendocrine_gland	0.86765591
81	MP0005636_abnormal_mineral_homeostasis	0.85758546
82	MP0000689_abnormal_spleen_morphology	0.85321692
83	MP0001963_abnormal_hearing_physiology	0.84856687
84	MP0003252_abnormal_bile_duct	0.83994285
85	MP0002733_abnormal_thermal_nociception	0.83587726
86	MP0001845_abnormal_inflammatory_respons	0.83466765
87	MP0005410_abnormal_fertilization	0.83293868
88	MP0002735_abnormal_chemical_nociception	0.82231943
89	MP0001440_abnormal_grooming_behavior	0.81719603
90	MP0002405_respiratory_system_inflammati	0.81234967
91	MP0002693_abnormal_pancreas_physiology	0.77835830
92	MP0000049_abnormal_middle_ear	0.77618259
93	MP0010155_abnormal_intestine_physiology	0.75823293
94	MP0005360_urolithiasis	0.75767349
95	MP0003786_premature_aging	0.74947204
96	MP0005174_abnormal_tail_pigmentation	0.71878584
97	MP0002429_abnormal_blood_cell	0.71878391
98	MP0000026_abnormal_inner_ear	0.71673803
99	MP0005195_abnormal_posterior_eye	0.71339105
100	MP0003638_abnormal_response/metabolism_	0.71311513

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.50937392
2	Congenital stationary night blindness (HP:0007642)	4.07503021
3	Mitochondrial inheritance (HP:0001427)	4.04663306
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.02908306
5	Progressive macrocephaly (HP:0004481)	3.74211160
6	Acute encephalopathy (HP:0006846)	3.70753343
7	Reticulocytopenia (HP:0001896)	3.68531191
8	Increased IgM level (HP:0003496)	3.58397488
9	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.54910027
10	IgG deficiency (HP:0004315)	3.54272965
11	Pancreatic cysts (HP:0001737)	3.48530646
12	Increased CSF lactate (HP:0002490)	3.42237395
13	Elevated erythrocyte sedimentation rate (HP:0003565)	3.36430043
14	Pancreatic fibrosis (HP:0100732)	3.29386822
15	Abnormality of cells of the erythroid lineage (HP:0012130)	3.27546928
16	3-Methylglutaconic aciduria (HP:0003535)	3.17714944
17	Abnormality of midbrain morphology (HP:0002418)	3.15830402
18	Molar tooth sign on MRI (HP:0002419)	3.15830402
19	True hermaphroditism (HP:0010459)	3.05218461
20	Hepatocellular necrosis (HP:0001404)	3.03460555
21	Abnormality of T cell number (HP:0011839)	3.03334449
22	Hypoproteinemia (HP:0003075)	3.02437058
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.98589664
24	Cerebral edema (HP:0002181)	2.93398446
25	Aplastic anemia (HP:0001915)	2.92673051
26	Increased hepatocellular lipid droplets (HP:0006565)	2.88974974
27	Abnormal number of erythroid precursors (HP:0012131)	2.85673263
28	T lymphocytopenia (HP:0005403)	2.76292124
29	Hepatic necrosis (HP:0002605)	2.71680689
30	Abnormality of B cell number (HP:0010975)	2.66693311
31	Severe combined immunodeficiency (HP:0004430)	2.66038982
32	Optic disc pallor (HP:0000543)	2.65918128
33	Increased intramyocellular lipid droplets (HP:0012240)	2.64030855
34	Lipid accumulation in hepatocytes (HP:0006561)	2.61739570
35	Abnormality of T cells (HP:0002843)	2.58116883
36	Attenuation of retinal blood vessels (HP:0007843)	2.57614512
37	Macrocytic anemia (HP:0001972)	2.54993370
38	Abolished electroretinogram (ERG) (HP:0000550)	2.54450310
39	Abnormality of the renal cortex (HP:0011035)	2.50330691
40	Autoimmune hemolytic anemia (HP:0001890)	2.46562143
41	Medial flaring of the eyebrow (HP:0010747)	2.43707943
42	Pallor (HP:0000980)	2.42233601
43	Absent thumb (HP:0009777)	2.39884333
44	Stomatitis (HP:0010280)	2.39191415
45	Renal Fanconi syndrome (HP:0001994)	2.37869880
46	Nephronophthisis (HP:0000090)	2.35700376
47	Agammaglobulinemia (HP:0004432)	2.30798225
48	Pendular nystagmus (HP:0012043)	2.29853234
49	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.28237539
50	Thyroiditis (HP:0100646)	2.27810341
51	Pancytopenia (HP:0001876)	2.25610790
52	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.24678471
53	Decreased central vision (HP:0007663)	2.24540573
54	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.23835416
55	Cystic liver disease (HP:0006706)	2.18510061
56	Increased muscle lipid content (HP:0009058)	2.16943356
57	Keratoconus (HP:0000563)	2.16936423
58	Increased corneal curvature (HP:0100692)	2.16936423
59	Colon cancer (HP:0003003)	2.16883745
60	Abnormality of the prostate (HP:0008775)	2.15965018
61	Asplenia (HP:0001746)	2.14461003
62	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.13737455
63	Lactic acidosis (HP:0003128)	2.11589122
64	Increased serum lactate (HP:0002151)	2.10334507
65	Abnormality of the renal medulla (HP:0100957)	2.10292405
66	Type II lissencephaly (HP:0007260)	2.06436708
67	Polydipsia (HP:0001959)	2.03578449
68	Abnormal drinking behavior (HP:0030082)	2.03578449
69	Panhypogammaglobulinemia (HP:0003139)	2.03218753
70	Methylmalonic acidemia (HP:0002912)	2.03134217
71	Sclerocornea (HP:0000647)	2.01786009
72	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.01268624
73	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.01268624
74	Respiratory failure (HP:0002878)	1.99553572
75	Abnormality of T cell physiology (HP:0011840)	1.97346165
76	Abnormality of DNA repair (HP:0003254)	1.96936084
77	Encephalitis (HP:0002383)	1.96769820
78	Abnormality of eosinophils (HP:0001879)	1.95449830
79	Autoimmune thrombocytopenia (HP:0001973)	1.94647388
80	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.93335380
81	Exertional dyspnea (HP:0002875)	1.93228223
82	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.92782645
83	Lethargy (HP:0001254)	1.91716383
84	B lymphocytopenia (HP:0010976)	1.90389055
85	Leukodystrophy (HP:0002415)	1.90264467
86	Anencephaly (HP:0002323)	1.89589922
87	Hyperglycinemia (HP:0002154)	1.89338793
88	Combined immunodeficiency (HP:0005387)	1.87917899
89	Renal cortical cysts (HP:0000803)	1.86354756
90	Postaxial foot polydactyly (HP:0001830)	1.85835871
91	Chronic mucocutaneous candidiasis (HP:0002728)	1.84724466
92	Recurrent cutaneous fungal infections (HP:0011370)	1.84724466
93	Polyuria (HP:0000103)	1.84243165
94	Abnormality of the renal collecting system (HP:0004742)	1.83458254
95	Stenosis of the external auditory canal (HP:0000402)	1.82172485
96	Type 2 muscle fiber atrophy (HP:0003554)	1.80684048
97	Methylmalonic aciduria (HP:0012120)	1.80453925
98	Exercise intolerance (HP:0003546)	1.78446076
99	Aplasia/hypoplasia of the uterus (HP:0008684)	1.77028830
100	Male pseudohermaphroditism (HP:0000037)	1.76807600

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	4.44444805
2	TXK	4.28901807
3	KDR	3.63734065
4	BCKDK	2.79287808
5	ZAK	2.56910663
6	GRK1	2.53676275
7	VRK2	2.51958479
8	MAP4K1	2.47670256
9	TLK1	2.46005260
10	PINK1	2.43536165
11	ADRBK2	2.34904990
12	CDK19	2.08455631
13	PASK	2.04914825
14	ITK	1.97033207
15	TAOK3	1.85401300
16	WNK4	1.80134519
17	VRK1	1.79293903
18	NUAK1	1.76397192
19	MAP4K2	1.75334707
20	MAP3K12	1.74347591
21	TEC	1.66680206
22	FRK	1.61596151
23	MUSK	1.54026502
24	MAP3K11	1.45584850
25	LIMK1	1.36582893
26	CAMKK2	1.36195796
27	CAMKK1	1.29124419
28	SYK	1.26236047
29	DYRK2	1.20185698
30	GRK6	1.17244952
31	PRKCQ	1.16668518
32	TNK2	1.10337331
33	DAPK1	1.06388243
34	OXSR1	1.01725505
35	BTK	1.01100653
36	FES	0.95942134
37	STK16	0.94855116
38	INSRR	0.93547210
39	IKBKB	0.93224688
40	TIE1	0.90565972
41	MAPKAPK3	0.89775062
42	STK39	0.89462605
43	CSNK1G3	0.89405835
44	WNK3	0.86413326
45	LYN	0.85602663
46	MAPK13	0.80415492
47	LCK	0.79318117
48	ADRBK1	0.79030446
49	NME1	0.76506240
50	RPS6KA5	0.75712667
51	MAP2K7	0.74274291
52	PIK3CA	0.71833993
53	PIK3CG	0.71532522
54	CSNK1G2	0.69747241
55	DAPK3	0.69407115
56	TESK1	0.68748747
57	GRK7	0.68732111
58	KIT	0.66885706
59	BCR	0.66678044
60	MYLK	0.66305937
61	IKBKE	0.65065823
62	OBSCN	0.63655726
63	CSNK1G1	0.61144253
64	MAP3K4	0.59295897
65	CSF1R	0.58196865
66	PRKACA	0.56759675
67	PHKG1	0.56446092
68	PHKG2	0.56446092
69	MAPK15	0.54615043
70	DAPK2	0.53883066
71	MAP2K6	0.53000786
72	CAMK1	0.52910056
73	CSNK1A1L	0.52026101
74	PRKCG	0.51842293
75	BMPR1B	0.51051949
76	LRRK2	0.49414078
77	PRKCA	0.48858940
78	IGF1R	0.46426808
79	PLK4	0.44598040
80	CSK	0.39718893
81	CAMK2A	0.38669250
82	PRKCH	0.38136524
83	PKN1	0.37354203
84	PIM1	0.37283149
85	JAK3	0.36985094
86	AURKA	0.36606077
87	FYN	0.33890749
88	PAK3	0.33837756
89	MAPKAPK5	0.33187779
90	ABL2	0.33153336
91	GRK5	0.32881205
92	CSNK2A2	0.32663327
93	CSNK1A1	0.32611097
94	PRKCD	0.32155293
95	CDK8	0.31857057
96	CSNK2A1	0.31616713
97	ABL1	0.28368013
98	PRKCE	0.28229528
99	PIM2	0.27769178
100	RPS6KA4	0.27483148

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.33917948
2	Primary immunodeficiency_Homo sapiens_hsa05340	4.20438687
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.93259081
4	Proteasome_Homo sapiens_hsa03050	3.25520506
5	Parkinsons disease_Homo sapiens_hsa05012	3.18936569
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.52764830
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.44390741
8	Allograft rejection_Homo sapiens_hsa05330	2.43574446
9	Phototransduction_Homo sapiens_hsa04744	2.19738103
10	Alzheimers disease_Homo sapiens_hsa05010	2.10033645
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.09730163
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.09217422
13	Cardiac muscle contraction_Homo sapiens_hsa04260	2.01088231
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.99214161
15	Asthma_Homo sapiens_hsa05310	1.99182259
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.93055676
17	Huntingtons disease_Homo sapiens_hsa05016	1.92664385
18	RNA polymerase_Homo sapiens_hsa03020	1.71753032
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.68758658
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.68401487
21	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.63134277
22	Protein export_Homo sapiens_hsa03060	1.57775409
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.52768440
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.50330687
25	Homologous recombination_Homo sapiens_hsa03440	1.47513751
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.45273644
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.44503491
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.36954643
29	RNA degradation_Homo sapiens_hsa03018	1.36407083
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.29057703
31	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.25661860
32	Caffeine metabolism_Homo sapiens_hsa00232	1.25442128
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.23796054
34	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.18648846
35	One carbon pool by folate_Homo sapiens_hsa00670	1.16392296
36	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.10382477
37	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.01635342
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.00414731
39	Peroxisome_Homo sapiens_hsa04146	0.97087800
40	Collecting duct acid secretion_Homo sapiens_hsa04966	0.93376167
41	Olfactory transduction_Homo sapiens_hsa04740	0.92043774
42	Nicotine addiction_Homo sapiens_hsa05033	0.89396388
43	Pyrimidine metabolism_Homo sapiens_hsa00240	0.89120404
44	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.88982043
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.88723706
46	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.88681054
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83932937
48	Butanoate metabolism_Homo sapiens_hsa00650	0.80633757
49	Purine metabolism_Homo sapiens_hsa00230	0.77913141
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76129799
51	Retinol metabolism_Homo sapiens_hsa00830	0.73650264
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.73516609
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72953682
54	Basal transcription factors_Homo sapiens_hsa03022	0.72532865
55	Viral myocarditis_Homo sapiens_hsa05416	0.72241172
56	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.72105000
57	Propanoate metabolism_Homo sapiens_hsa00640	0.70627567
58	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.69583463
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.68576224
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.67213850
61	Mismatch repair_Homo sapiens_hsa03430	0.65167848
62	Sulfur relay system_Homo sapiens_hsa04122	0.64079599
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.63917600
64	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.63417004
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62753452
66	DNA replication_Homo sapiens_hsa03030	0.62247861
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.61500213
68	Morphine addiction_Homo sapiens_hsa05032	0.60387583
69	Base excision repair_Homo sapiens_hsa03410	0.60375894
70	Taste transduction_Homo sapiens_hsa04742	0.59605715
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57114667
72	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.56751688
73	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.52660884
74	Metabolic pathways_Homo sapiens_hsa01100	0.51352323
75	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.50145966
76	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.49369188
77	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.48954970
78	Measles_Homo sapiens_hsa05162	0.47363838
79	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.46639631
80	Malaria_Homo sapiens_hsa05144	0.46169972
81	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.46088858
82	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.45583581
83	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.42892177
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.42051289
85	Selenocompound metabolism_Homo sapiens_hsa00450	0.36644079
86	GABAergic synapse_Homo sapiens_hsa04727	0.35916554
87	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.34716621
88	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.31809948
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.29500183
90	Serotonergic synapse_Homo sapiens_hsa04726	0.25839462
91	Regulation of autophagy_Homo sapiens_hsa04140	0.25636781
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.25045735
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.23533938
94	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.22358659
95	Salivary secretion_Homo sapiens_hsa04970	0.22256879
96	Pyruvate metabolism_Homo sapiens_hsa00620	0.20520027
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.19270769
98	Spliceosome_Homo sapiens_hsa03040	0.18994445
99	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.18479137
100	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.16338019

RPL34P18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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