RPL34P21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of respiratory burst (GO:0060267)5.54377112
2positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.60092381
3protein prenylation (GO:0018342)4.58324393
4prenylation (GO:0097354)4.58324393
5water-soluble vitamin biosynthetic process (GO:0042364)4.29517803
6cellular ketone body metabolic process (GO:0046950)4.27128793
7regulation of transmission of nerve impulse (GO:0051969)4.25885478
8mitochondrial respiratory chain complex I assembly (GO:0032981)4.23193758
9NADH dehydrogenase complex assembly (GO:0010257)4.23193758
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.23193758
11mechanosensory behavior (GO:0007638)4.16104570
12diterpenoid biosynthetic process (GO:0016102)4.02177486
13protein complex biogenesis (GO:0070271)3.97595646
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.93210659
15neural tube formation (GO:0001841)3.89786476
16mitochondrial calcium ion homeostasis (GO:0051560)3.88041879
17phosphatidylinositol acyl-chain remodeling (GO:0036149)3.86076473
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.85345625
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.84470762
20termination of RNA polymerase III transcription (GO:0006386)3.84470762
21sphingomyelin metabolic process (GO:0006684)3.82775110
22protein neddylation (GO:0045116)3.77569346
23ketone body metabolic process (GO:1902224)3.75868619
24mitochondrial calcium ion transport (GO:0006851)3.74449494
25behavioral response to nicotine (GO:0035095)3.72736178
26terpenoid biosynthetic process (GO:0016114)3.71231587
27positive regulation of glycolytic process (GO:0045821)3.69139227
28signal peptide processing (GO:0006465)3.67958200
29mitochondrial respiratory chain complex assembly (GO:0033108)3.67845972
30phosphatidylserine acyl-chain remodeling (GO:0036150)3.66563494
31negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.63965794
32negative regulation of T-helper cell differentiation (GO:0045623)3.63965794
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.55942549
34ATP synthesis coupled proton transport (GO:0015986)3.55942549
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.49200391
36regulation of immunoglobulin secretion (GO:0051023)3.48457001
37negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.47400219
38monoubiquitinated protein deubiquitination (GO:0035520)3.46834497
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.45724407
40respiratory electron transport chain (GO:0022904)3.42462322
41auditory receptor cell differentiation (GO:0042491)3.42147165
42electron transport chain (GO:0022900)3.41740442
43protein heterotetramerization (GO:0051290)3.36145842
44endoderm formation (GO:0001706)3.34560570
45piRNA metabolic process (GO:0034587)3.30387204
46inner ear receptor cell differentiation (GO:0060113)3.24862034
47DNA deamination (GO:0045006)3.23570580
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.18043371
49detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.17393738
50positive regulation of fatty acid oxidation (GO:0046321)3.14613083
51mast cell activation involved in immune response (GO:0002279)3.10055103
52mast cell degranulation (GO:0043303)3.10055103
53icosanoid secretion (GO:0032309)3.09647508
54arachidonic acid secretion (GO:0050482)3.09647508
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.09053886
56exocrine pancreas development (GO:0031017)3.07603937
57proteasome assembly (GO:0043248)3.05276517
58protein K11-linked deubiquitination (GO:0035871)3.04689753
59rRNA methylation (GO:0031167)3.04159500
60keratinocyte development (GO:0003334)3.02788822
61rRNA modification (GO:0000154)3.01863998
62regulation of chronic inflammatory response (GO:0002676)2.99987651
63regulation of B cell receptor signaling pathway (GO:0050855)2.97338024
64DNA methylation involved in gamete generation (GO:0043046)2.91966612
65protein-cofactor linkage (GO:0018065)2.91681905
66hydrogen ion transmembrane transport (GO:1902600)2.87841903
67negative regulation of alpha-beta T cell differentiation (GO:0046639)2.86773916
68regulation of isotype switching to IgG isotypes (GO:0048302)2.85271673
69photoreceptor cell maintenance (GO:0045494)2.84874589
70positive regulation of granulocyte differentiation (GO:0030854)2.82414991
71negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.81772130
72ribosomal small subunit assembly (GO:0000028)2.75695213
73branched-chain amino acid catabolic process (GO:0009083)2.75325906
74drug catabolic process (GO:0042737)2.74647117
75proton transport (GO:0015992)2.73903187
76nonmotile primary cilium assembly (GO:0035058)2.73867434
77phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.73464997
78cell wall macromolecule catabolic process (GO:0016998)2.69501888
79regulation of cilium movement (GO:0003352)2.67805501
80hydrogen transport (GO:0006818)2.67209240
81glyoxylate metabolic process (GO:0046487)2.64748468
82intracellular protein transmembrane import (GO:0044743)2.63625486
83regulation of vitamin D biosynthetic process (GO:0060556)2.63624463
84epithelial cilium movement (GO:0003351)2.63301687
85oxidative demethylation (GO:0070989)2.62859153
86DNA double-strand break processing (GO:0000729)2.57575817
87metallo-sulfur cluster assembly (GO:0031163)2.56525430
88iron-sulfur cluster assembly (GO:0016226)2.56525430
89peptidyl-tyrosine autophosphorylation (GO:0038083)2.55273348
90aldehyde catabolic process (GO:0046185)2.55121032
91indolalkylamine metabolic process (GO:0006586)2.54366013
92GTP biosynthetic process (GO:0006183)2.53966167
93positive regulation of glycogen biosynthetic process (GO:0045725)2.52815929
94DNA catabolic process, exonucleolytic (GO:0000738)2.51428666
95N-terminal protein amino acid acetylation (GO:0006474)2.50461135
96phosphatidylcholine acyl-chain remodeling (GO:0036151)2.50029018
97fatty acid derivative transport (GO:1901571)2.49533230
98icosanoid transport (GO:0071715)2.49533230
99kinetochore assembly (GO:0051382)2.47235104
100respiratory chain complex IV assembly (GO:0008535)2.45983748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.43168037
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.13364210
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.08338636
4FLI1_27457419_Chip-Seq_LIVER_Mouse3.01982594
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.84758181
6ZNF274_21170338_ChIP-Seq_K562_Hela2.59432713
7EWS_26573619_Chip-Seq_HEK293_Human2.53724608
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.46250730
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.42939905
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.35338347
11FUS_26573619_Chip-Seq_HEK293_Human2.34311015
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30728365
13ELK1_19687146_ChIP-ChIP_HELA_Human2.25309809
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18452796
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16345352
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16130912
17ER_23166858_ChIP-Seq_MCF-7_Human2.15445325
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13709678
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.00103604
20TAF15_26573619_Chip-Seq_HEK293_Human1.95677863
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.94506580
22SUZ12_27294783_Chip-Seq_NPCs_Mouse1.90327098
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89549793
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.87595804
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85623883
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84924644
27TP53_22573176_ChIP-Seq_HFKS_Human1.80382098
28VDR_23849224_ChIP-Seq_CD4+_Human1.80223643
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.75521916
30P300_19829295_ChIP-Seq_ESCs_Human1.70805535
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.70519041
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70469749
33EZH2_27294783_Chip-Seq_NPCs_Mouse1.60789327
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47942013
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45575041
36CBP_20019798_ChIP-Seq_JUKART_Human1.45575041
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44991305
38GATA3_21878914_ChIP-Seq_MCF-7_Human1.43595260
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42606051
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.41872442
41BCAT_22108803_ChIP-Seq_LS180_Human1.40260397
42CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39261200
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37959223
44TCF4_22108803_ChIP-Seq_LS180_Human1.36804089
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36102608
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31054941
47AR_20517297_ChIP-Seq_VCAP_Human1.30678715
48CRX_20693478_ChIP-Seq_RETINA_Mouse1.29952080
49IGF1R_20145208_ChIP-Seq_DFB_Human1.28650951
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28092814
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25936692
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22944922
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22400694
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.22400694
55MYC_18940864_ChIP-ChIP_HL60_Human1.19127056
56OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18376809
57FOXP3_21729870_ChIP-Seq_TREG_Human1.18215714
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17588333
59STAT3_18555785_Chip-Seq_ESCs_Mouse1.17076540
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15617048
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.15487061
62SMAD4_21741376_ChIP-Seq_EPCs_Human1.14565602
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.13101167
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12311917
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12159536
66NANOG_19829295_ChIP-Seq_ESCs_Human1.11661972
67SOX2_19829295_ChIP-Seq_ESCs_Human1.11661972
68FOXH1_21741376_ChIP-Seq_EPCs_Human1.11041210
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10554206
70P53_22387025_ChIP-Seq_ESCs_Mouse1.10431603
71CDX2_22108803_ChIP-Seq_LS180_Human1.09773099
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.09735710
73P300_18555785_Chip-Seq_ESCs_Mouse1.09078480
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.09049457
75CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08425587
76NFYB_21822215_ChIP-Seq_K562_Human1.08421039
77GATA3_26560356_Chip-Seq_TH2_Human1.08257353
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08212521
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07811673
80TBL1_22424771_ChIP-Seq_293T_Human1.07623844
81EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06949284
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06765154
83RBPJ_21746931_ChIP-Seq_IB4_Human1.05130208
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.04807942
85ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04480218
86AR_21572438_ChIP-Seq_LNCaP_Human1.04322563
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04005213
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03937801
89GATA6_21074721_ChIP-Seq_CACO-2_Human1.03463294
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03457355
91RUNX2_22187159_ChIP-Seq_PCA_Human1.02858185
92TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01931495
93NFYA_21822215_ChIP-Seq_K562_Human1.01521139
94TCF4_23295773_ChIP-Seq_U87_Human1.00608404
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.00225051
96NMYC_18555785_Chip-Seq_ESCs_Mouse0.99800839
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99751627
98AR_25329375_ChIP-Seq_VCAP_Human0.99124848
99PHF8_20622853_ChIP-Seq_HELA_Human0.98869914
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98234691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005084_abnormal_gallbladder_morpholo3.69661645
2MP0001873_stomach_inflammation3.43398679
3MP0003646_muscle_fatigue3.33339944
4MP0001485_abnormal_pinna_reflex3.30061706
5MP0004742_abnormal_vestibular_system3.00933548
6MP0008875_abnormal_xenobiotic_pharmacok2.77813578
7MP0005670_abnormal_white_adipose2.73969504
8MP0006292_abnormal_olfactory_placode2.64176928
9MP0005451_abnormal_body_composition2.38021537
10MP0000427_abnormal_hair_cycle2.37405076
11MP0003283_abnormal_digestive_organ2.21307245
12MP0005365_abnormal_bile_salt2.12757012
13MP0005551_abnormal_eye_electrophysiolog2.11166179
14MP0001486_abnormal_startle_reflex2.06332993
15MP0001764_abnormal_homeostasis1.78619397
16MP0008872_abnormal_physiological_respon1.76955570
17MP0004043_abnormal_pH_regulation1.75997118
18MP0002736_abnormal_nociception_after1.75736993
19MP0005671_abnormal_response_to1.69135497
20MP0004142_abnormal_muscle_tone1.68312145
21MP0006072_abnormal_retinal_apoptosis1.66802337
22MP0002653_abnormal_ependyma_morphology1.66258433
23MP0004885_abnormal_endolymph1.61027606
24MP0004019_abnormal_vitamin_homeostasis1.58986301
25MP0001348_abnormal_lacrimal_gland1.58277271
26MP0003119_abnormal_digestive_system1.56701047
27MP0001293_anophthalmia1.54077081
28MP0006036_abnormal_mitochondrial_physio1.51112021
29MP0003763_abnormal_thymus_physiology1.44439947
30MP0008877_abnormal_DNA_methylation1.43141193
31MP0006035_abnormal_mitochondrial_morpho1.41050759
32MP0002009_preneoplasia1.39638247
33MP0008057_abnormal_DNA_replication1.39342752
34MP0002166_altered_tumor_susceptibility1.39116037
35MP0001986_abnormal_taste_sensitivity1.38453948
36MP0005646_abnormal_pituitary_gland1.33201942
37MP0002234_abnormal_pharynx_morphology1.29574410
38MP0000685_abnormal_immune_system1.28728784
39MP0002254_reproductive_system_inflammat1.25568512
40MP0008058_abnormal_DNA_repair1.24917138
41MP0010386_abnormal_urinary_bladder1.24091826
42MP0002160_abnormal_reproductive_system1.23658817
43MP0001756_abnormal_urination1.20894942
44MP0003718_maternal_effect1.16312651
45MP0005389_reproductive_system_phenotype1.16212486
46MP0003786_premature_aging1.15187311
47MP0003195_calcinosis1.14772926
48MP0003938_abnormal_ear_development1.13685081
49MP0005410_abnormal_fertilization1.13070676
50MP0001835_abnormal_antigen_presentation1.12750827
51MP0006276_abnormal_autonomic_nervous1.12390627
52MP0005645_abnormal_hypothalamus_physiol1.10537087
53MP0005448_abnormal_energy_balance1.10522595
54MP0002102_abnormal_ear_morphology1.09929035
55MP0005310_abnormal_salivary_gland1.08121088
56MP0001501_abnormal_sleep_pattern1.07852073
57MP0001529_abnormal_vocalization1.06789811
58MP0002876_abnormal_thyroid_physiology1.06254671
59MP0001968_abnormal_touch/_nociception1.05299730
60MP0003252_abnormal_bile_duct1.04384698
61MP0004133_heterotaxia1.02150787
62MP0003878_abnormal_ear_physiology1.01703458
63MP0005377_hearing/vestibular/ear_phenot1.01703458
64MP0005253_abnormal_eye_physiology1.00474557
65MP0002006_tumorigenesis0.96194719
66MP0003937_abnormal_limbs/digits/tail_de0.93986501
67MP0003638_abnormal_response/metabolism_0.93042411
68MP0001663_abnormal_digestive_system0.92393889
69MP0000631_abnormal_neuroendocrine_gland0.91783501
70MP0001800_abnormal_humoral_immune0.90549497
71MP0002909_abnormal_adrenal_gland0.90508304
72MP0005386_behavior/neurological_phenoty0.89065769
73MP0004924_abnormal_behavior0.89065769
74MP0002837_dystrophic_cardiac_calcinosis0.87064763
75MP0003787_abnormal_imprinting0.86556488
76MP0001919_abnormal_reproductive_system0.85654670
77MP0003828_pulmonary_edema0.85383663
78MP0002735_abnormal_chemical_nociception0.82958621
79MP0008995_early_reproductive_senescence0.82164727
80MP0002693_abnormal_pancreas_physiology0.82140023
81MP0001963_abnormal_hearing_physiology0.81555721
82MP0002233_abnormal_nose_morphology0.79874402
83MP0009764_decreased_sensitivity_to0.79644958
84MP0009046_muscle_twitch0.79317837
85MP0001929_abnormal_gametogenesis0.77722807
86MP0001984_abnormal_olfaction0.77455379
87MP0005408_hypopigmentation0.76751975
88MP0002396_abnormal_hematopoietic_system0.75910129
89MP0010094_abnormal_chromosome_stability0.74566370
90MP0001944_abnormal_pancreas_morphology0.73501028
91MP0003880_abnormal_central_pattern0.72349146
92MP0002277_abnormal_respiratory_mucosa0.72019318
93MP0003698_abnormal_male_reproductive0.71848015
94MP0000470_abnormal_stomach_morphology0.70602295
95MP0009115_abnormal_fat_cell0.69808092
96MP0009643_abnormal_urine_homeostasis0.68867608
97MP0001790_abnormal_immune_system0.68222701
98MP0005387_immune_system_phenotype0.68222701
99MP0001145_abnormal_male_reproductive0.68198819
100MP0002210_abnormal_sex_determination0.66356193

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic islet-cell hyperplasia (HP:0004510)5.25895346
2Stomatitis (HP:0010280)4.71903920
3Congenital, generalized hypertrichosis (HP:0004540)4.61154974
4Hypoglycemic seizures (HP:0002173)4.10938178
5Pendular nystagmus (HP:0012043)4.06171787
6Hyperinsulinemic hypoglycemia (HP:0000825)3.89689597
73-Methylglutaconic aciduria (HP:0003535)3.78010688
8Pancreatic cysts (HP:0001737)3.55652368
9Molar tooth sign on MRI (HP:0002419)3.50602137
10Abnormality of midbrain morphology (HP:0002418)3.50602137
11Enlarged penis (HP:0000040)3.49255165
12Type II lissencephaly (HP:0007260)3.32870561
13IgG deficiency (HP:0004315)3.29016616
14Decreased central vision (HP:0007663)3.20250673
15Absent rod-and cone-mediated responses on ERG (HP:0007688)3.19653345
16Attenuation of retinal blood vessels (HP:0007843)3.18518413
17Hypoglycemic coma (HP:0001325)3.17477281
18Abnormal rod and cone electroretinograms (HP:0008323)3.03632461
19Increased IgM level (HP:0003496)3.02276748
20Cerebellar dysplasia (HP:0007033)3.01178048
21Long foot (HP:0001833)3.00132618
22Febrile seizures (HP:0002373)2.86368438
23B lymphocytopenia (HP:0010976)2.80522434
24Congenital stationary night blindness (HP:0007642)2.80091247
25Neuroendocrine neoplasm (HP:0100634)2.79632799
26Keratoconus (HP:0000563)2.78198063
27Increased corneal curvature (HP:0100692)2.78198063
28Pheochromocytoma (HP:0002666)2.76511467
29Symptomatic seizures (HP:0011145)2.65837330
30Acute necrotizing encephalopathy (HP:0006965)2.65829712
31Abnormality of B cell number (HP:0010975)2.62008779
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59754696
33Abnormality of alanine metabolism (HP:0010916)2.59754696
34Hyperalaninemia (HP:0003348)2.59754696
35Ketoacidosis (HP:0001993)2.59502993
36Acute encephalopathy (HP:0006846)2.58954285
37Clitoromegaly (HP:0000057)2.55573113
38Abnormality of endocrine pancreas physiology (HP:0012093)2.55058324
39Abnormality of the pancreatic islet cells (HP:0006476)2.55058324
40Optic disc pallor (HP:0000543)2.52075269
41Progressive macrocephaly (HP:0004481)2.48163907
42True hermaphroditism (HP:0010459)2.42073218
43Medial flaring of the eyebrow (HP:0010747)2.40272641
44Abnormality of the ileum (HP:0001549)2.35101255
45Chronic bronchitis (HP:0004469)2.35070569
46Abolished electroretinogram (ERG) (HP:0000550)2.34815157
47Pancreatic fibrosis (HP:0100732)2.33424567
48Cerebral hemorrhage (HP:0001342)2.33280912
49Nephronophthisis (HP:0000090)2.26841789
50Reticulocytopenia (HP:0001896)2.22067092
51Clubbing of toes (HP:0100760)2.17010262
52Ectopic kidney (HP:0000086)2.15821742
53Thick nail (HP:0001805)2.13448788
54Meckel diverticulum (HP:0002245)2.13409481
55Ketosis (HP:0001946)2.13381759
56Fatigue (HP:0012378)2.13347855
57Colon cancer (HP:0003003)2.11796592
58Female pseudohermaphroditism (HP:0010458)2.08441862
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.06579604
60Absent/shortened dynein arms (HP:0200106)2.06579604
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04651321
62Acute myeloid leukemia (HP:0004808)2.03452110
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.01534417
64Increased CSF lactate (HP:0002490)1.99049839
65Abnormal mitochondria in muscle tissue (HP:0008316)1.95996017
66Hyperglycemia (HP:0003074)1.95304455
67Bifid tongue (HP:0010297)1.95245886
68Mitochondrial inheritance (HP:0001427)1.94328347
69Genital tract atresia (HP:0001827)1.94313024
70Insulin-resistant diabetes mellitus (HP:0000831)1.94129237
71Vaginal atresia (HP:0000148)1.94091475
72Chorioretinal atrophy (HP:0000533)1.94028377
73Cellular immunodeficiency (HP:0005374)1.90846784
74Aplastic anemia (HP:0001915)1.89480407
75Elevated erythrocyte sedimentation rate (HP:0003565)1.89228748
76Abnormal lung lobation (HP:0002101)1.88074534
77Lethargy (HP:0001254)1.88000515
78Hypoplasia of the thymus (HP:0000778)1.87986878
79Chromsome breakage (HP:0040012)1.87890164
80Abnormality of chromosome stability (HP:0003220)1.87603119
81Homocystinuria (HP:0002156)1.87448398
82Abnormality of homocysteine metabolism (HP:0010919)1.87448398
83Abnormality of the renal medulla (HP:0100957)1.87418135
84Impulsivity (HP:0100710)1.85953910
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.85537108
86Abnormality of the prostate (HP:0008775)1.81857047
87Gaze-evoked nystagmus (HP:0000640)1.79836460
88Pancytopenia (HP:0001876)1.79539558
89Lissencephaly (HP:0001339)1.77923782
90Poor coordination (HP:0002370)1.77243050
91Bilateral microphthalmos (HP:0007633)1.76713059
92Methylmalonic aciduria (HP:0012120)1.76539066
93Methylmalonic acidemia (HP:0002912)1.76485021
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.76365691
95Absent thumb (HP:0009777)1.75708710
96Aplasia/Hypoplasia of the spleen (HP:0010451)1.74185657
97Asplenia (HP:0001746)1.73400671
98Cerebral edema (HP:0002181)1.71867302
99Abnormality of the preputium (HP:0100587)1.71552025
100Hyperglycinemia (HP:0002154)1.70762893

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR8.08894023
2FRK4.90028423
3NUAK13.59867387
4CASK3.09715262
5MKNK12.72443587
6WNK32.48344683
7PDK22.24254504
8MAP4K22.24068462
9ZAK2.16696963
10TAF12.10230962
11TNIK1.97855253
12SIK21.85389408
13VRK21.83038774
14MST41.77574241
15TAOK31.68168097
16PBK1.64605971
17PIK3CG1.63174755
18MAPKAPK51.58664858
19TLK11.49161526
20MKNK21.43186444
21BMPR21.34970860
22BRSK21.30690266
23ADRBK21.23686488
24NEK21.23617282
25EIF2AK31.22709073
26LATS11.22048420
27EPHA31.21416033
28STK38L1.13341177
29GRK11.12951313
30NLK1.06341561
31TEC1.04569717
32VRK11.04123545
33CDC71.01792120
34STK391.01712447
35AKT31.00506352
36BRD40.99908719
37NME10.99348308
38OXSR10.97640474
39MAP3K90.97469831
40TNK20.93331625
41EIF2AK10.92375660
42PLK40.91158159
43STK380.87193664
44STK30.86397920
45BCKDK0.85900679
46EIF2AK20.85154761
47ACVR1B0.83319450
48RPS6KA50.82449863
49NEK60.80849909
50CAMKK20.78880013
51PLK20.77205742
52NME20.76878320
53ITK0.75544917
54WNK40.75292768
55BMPR1B0.72925027
56PINK10.70768039
57STK40.70254261
58BUB10.67146131
59FLT30.65358406
60ADRBK10.62723780
61IRAK10.62471728
62LYN0.61205490
63TIE10.56234420
64PIK3CA0.54772925
65TRIM280.51027639
66IKBKB0.50357610
67FER0.49596769
68TXK0.48735395
69DAPK20.48403329
70BLK0.47521316
71FES0.41819331
72PTK2B0.41335805
73DYRK1A0.41074633
74PRKAA20.39161400
75SYK0.37602199
76BRSK10.37399358
77TGFBR20.37188925
78CAMK10.37021032
79FGFR20.36234620
80PLK30.34921325
81WEE10.32178999
82CDK80.31388895
83IGF1R0.30423331
84CAMK40.28706514
85MAP4K10.27446820
86FGFR10.27393940
87CSNK1A10.27207673
88INSR0.25953974
89DYRK20.25037719
90SGK20.24210307
91GRK60.23146749
92PRKCH0.22352156
93PRKCA0.21207396
94GRK50.21183899
95TSSK60.21010058
96DAPK30.20733059
97PRKCE0.19873127
98PRKCG0.19846789
99EPHA40.19560874
100PRKCQ0.19185818

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.41230898
2Oxidative phosphorylation_Homo sapiens_hsa001903.36938644
3Asthma_Homo sapiens_hsa053103.10624194
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.86493775
5Homologous recombination_Homo sapiens_hsa034402.85767108
6Protein export_Homo sapiens_hsa030602.83353965
7RNA polymerase_Homo sapiens_hsa030202.75957823
8Linoleic acid metabolism_Homo sapiens_hsa005912.64881221
9Parkinsons disease_Homo sapiens_hsa050122.50853536
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26049759
11Ribosome_Homo sapiens_hsa030102.24527537
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.24079386
13Primary immunodeficiency_Homo sapiens_hsa053402.21169760
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97715493
15RNA degradation_Homo sapiens_hsa030181.95446093
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83716855
17Fanconi anemia pathway_Homo sapiens_hsa034601.79740478
18Huntingtons disease_Homo sapiens_hsa050161.79535124
19Ether lipid metabolism_Homo sapiens_hsa005651.71034727
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.69465756
21Autoimmune thyroid disease_Homo sapiens_hsa053201.68972476
22Allograft rejection_Homo sapiens_hsa053301.68017917
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.67537582
24Alzheimers disease_Homo sapiens_hsa050101.64447766
25Caffeine metabolism_Homo sapiens_hsa002321.50905849
26Olfactory transduction_Homo sapiens_hsa047401.41677116
27Basal transcription factors_Homo sapiens_hsa030221.39883640
28Phototransduction_Homo sapiens_hsa047441.39084770
29Ovarian steroidogenesis_Homo sapiens_hsa049131.37420764
30Cardiac muscle contraction_Homo sapiens_hsa042601.34623716
31Vitamin B6 metabolism_Homo sapiens_hsa007501.34027089
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25852860
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21596043
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20255066
35Vitamin digestion and absorption_Homo sapiens_hsa049771.19306199
36Arachidonic acid metabolism_Homo sapiens_hsa005901.17947331
37Selenocompound metabolism_Homo sapiens_hsa004501.17096687
38Nitrogen metabolism_Homo sapiens_hsa009101.12513515
39Propanoate metabolism_Homo sapiens_hsa006401.11315332
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10148970
41Collecting duct acid secretion_Homo sapiens_hsa049661.08475286
42Tryptophan metabolism_Homo sapiens_hsa003801.08023004
43Butanoate metabolism_Homo sapiens_hsa006501.03397392
44Taste transduction_Homo sapiens_hsa047421.02344939
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.00917400
46Hematopoietic cell lineage_Homo sapiens_hsa046400.95563126
47Pyrimidine metabolism_Homo sapiens_hsa002400.95402774
48Systemic lupus erythematosus_Homo sapiens_hsa053220.94612004
49Peroxisome_Homo sapiens_hsa041460.92568170
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91318318
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.88488039
52T cell receptor signaling pathway_Homo sapiens_hsa046600.88023995
53One carbon pool by folate_Homo sapiens_hsa006700.87142252
54Sphingolipid metabolism_Homo sapiens_hsa006000.85275199
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82869837
56Nicotine addiction_Homo sapiens_hsa050330.81470129
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79786470
58Purine metabolism_Homo sapiens_hsa002300.79641278
59Fatty acid degradation_Homo sapiens_hsa000710.79387218
60Nucleotide excision repair_Homo sapiens_hsa034200.73470840
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72354946
62Mismatch repair_Homo sapiens_hsa034300.71467823
63Chemical carcinogenesis_Homo sapiens_hsa052040.70524183
64Retinol metabolism_Homo sapiens_hsa008300.70520486
65RNA transport_Homo sapiens_hsa030130.69052067
66Arginine and proline metabolism_Homo sapiens_hsa003300.67474846
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65619540
68Folate biosynthesis_Homo sapiens_hsa007900.59047969
69Mineral absorption_Homo sapiens_hsa049780.58487720
70Glycerolipid metabolism_Homo sapiens_hsa005610.57692709
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55394427
72TGF-beta signaling pathway_Homo sapiens_hsa043500.55337998
73Metabolic pathways_Homo sapiens_hsa011000.54211008
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54069749
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53843342
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.53000952
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52528895
78Non-homologous end-joining_Homo sapiens_hsa034500.50981285
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47927453
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45297667
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43521342
82Pyruvate metabolism_Homo sapiens_hsa006200.42400515
83Circadian rhythm_Homo sapiens_hsa047100.41470872
84Rheumatoid arthritis_Homo sapiens_hsa053230.39198300
85DNA replication_Homo sapiens_hsa030300.36762328
86Serotonergic synapse_Homo sapiens_hsa047260.35973062
87Glutamatergic synapse_Homo sapiens_hsa047240.35486172
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34128581
89Fat digestion and absorption_Homo sapiens_hsa049750.32015843
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.29713499
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29354225
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29246723
93GABAergic synapse_Homo sapiens_hsa047270.28697094
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27721010
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.24432929
96Histidine metabolism_Homo sapiens_hsa003400.22252208
97FoxO signaling pathway_Homo sapiens_hsa040680.22187622
98Sulfur relay system_Homo sapiens_hsa041220.21125421
99p53 signaling pathway_Homo sapiens_hsa041150.20675794
100mRNA surveillance pathway_Homo sapiens_hsa030150.20247365

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »