RPL34P23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)9.54835820
2viral transcription (GO:0019083)7.55630267
3translational termination (GO:0006415)7.12303649
4ribosomal small subunit biogenesis (GO:0042274)6.53092900
5ribosomal small subunit assembly (GO:0000028)6.23139209
6positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)6.12372657
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.04615698
8cotranslational protein targeting to membrane (GO:0006613)5.98604976
9protein targeting to ER (GO:0045047)5.94458981
10translational elongation (GO:0006414)5.94059810
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.81079463
12protein localization to endoplasmic reticulum (GO:0070972)5.54213555
13viral life cycle (GO:0019058)5.52253108
14regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.39430577
15cellular protein complex disassembly (GO:0043624)5.27172837
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.01144981
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.63058521
18ATP synthesis coupled proton transport (GO:0015986)4.63058521
19translational initiation (GO:0006413)4.54460016
20ribosomal large subunit biogenesis (GO:0042273)4.52721776
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.48709553
22behavioral response to nicotine (GO:0035095)4.36905881
23piRNA metabolic process (GO:0034587)4.35922768
24protein complex disassembly (GO:0043241)4.33637490
25macromolecular complex disassembly (GO:0032984)4.22964182
26oxygen transport (GO:0015671)4.13231940
27negative regulation of B cell apoptotic process (GO:0002903)4.11849389
28regulation of isotype switching to IgG isotypes (GO:0048302)4.00984136
29protein targeting to membrane (GO:0006612)3.95016092
30positive regulation of fatty acid transport (GO:2000193)3.94459656
31S-adenosylmethionine metabolic process (GO:0046500)3.83853285
32positive regulation of prostaglandin secretion (GO:0032308)3.68155221
33DNA deamination (GO:0045006)3.67849758
34translation (GO:0006412)3.66794488
35rRNA catabolic process (GO:0016075)3.62366459
36cell wall macromolecule catabolic process (GO:0016998)3.55008790
37nuclear-transcribed mRNA catabolic process (GO:0000956)3.53614327
38nonmotile primary cilium assembly (GO:0035058)3.50023978
39homocysteine metabolic process (GO:0050667)3.49271888
40DNA methylation involved in gamete generation (GO:0043046)3.49123300
41gas transport (GO:0015669)3.49047356
42positive regulation of interleukin-17 production (GO:0032740)3.48920539
43regulation of regulatory T cell differentiation (GO:0045589)3.46097628
44ribonucleoprotein complex biogenesis (GO:0022613)3.41262440
45aggressive behavior (GO:0002118)3.35900722
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.35430954
47mRNA catabolic process (GO:0006402)3.35003710
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.34334304
49motile cilium assembly (GO:0044458)3.27217087
50positive regulation of icosanoid secretion (GO:0032305)3.21759285
51chaperone-mediated protein transport (GO:0072321)3.21041205
52cellular response to interferon-beta (GO:0035458)3.14563738
53positive regulation of activated T cell proliferation (GO:0042104)3.13176887
54regulation of prostaglandin secretion (GO:0032306)3.08788292
55organelle disassembly (GO:1903008)3.00351034
56mannosylation (GO:0097502)2.97729387
57male meiosis (GO:0007140)2.96216104
58cell wall macromolecule metabolic process (GO:0044036)2.95932742
59ATP biosynthetic process (GO:0006754)2.95550611
60regulation of B cell apoptotic process (GO:0002902)2.94137213
61regulation of immunoglobulin secretion (GO:0051023)2.94129512
62RNA catabolic process (GO:0006401)2.93719374
63positive regulation of T cell apoptotic process (GO:0070234)2.93688072
64myoblast migration (GO:0051451)2.93662256
65pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89809885
66preassembly of GPI anchor in ER membrane (GO:0016254)2.89751603
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89696959
68positive regulation of isotype switching (GO:0045830)2.89474889
69embryonic hemopoiesis (GO:0035162)2.89215063
70resolution of meiotic recombination intermediates (GO:0000712)2.85600482
71substrate-independent telencephalic tangential migration (GO:0021826)2.85043930
72substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.85043930
73exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84198020
74ribonucleoprotein complex disassembly (GO:0032988)2.83143842
75cellular biogenic amine catabolic process (GO:0042402)2.83068720
76amine catabolic process (GO:0009310)2.83068720
77indolalkylamine metabolic process (GO:0006586)2.82659929
78nucleotide transmembrane transport (GO:1901679)2.81034854
79interferon-gamma production (GO:0032609)2.80194900
80cellular component biogenesis (GO:0044085)2.76807031
81rRNA processing (GO:0006364)2.76027682
82positive regulation of DNA recombination (GO:0045911)2.75442679
83positive regulation of catecholamine secretion (GO:0033605)2.75397162
84rRNA metabolic process (GO:0016072)2.74878810
85somite development (GO:0061053)2.71910854
86regulation of female receptivity (GO:0045924)2.70709054
87establishment of protein localization to mitochondrial membrane (GO:0090151)2.70638947
88establishment of protein localization to membrane (GO:0090150)2.69123455
89pseudouridine synthesis (GO:0001522)2.68225049
90response to interferon-beta (GO:0035456)2.66361438
91positive regulation of defense response to virus by host (GO:0002230)2.65333194
92positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.64964709
93peptidyl-histidine modification (GO:0018202)2.63448101
94viral protein processing (GO:0019082)2.62153558
95GPI anchor metabolic process (GO:0006505)2.61934861
96negative regulation of reactive oxygen species metabolic process (GO:2000378)2.59564362
97cytidine metabolic process (GO:0046087)2.57724948
98cytidine catabolic process (GO:0006216)2.57724948
99cytidine deamination (GO:0009972)2.57724948
100negative regulation of macrophage differentiation (GO:0045650)2.56444723

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.66033286
2VDR_22108803_ChIP-Seq_LS180_Human3.23733596
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.22042026
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09131918
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.61818032
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.52541629
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40338945
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28578914
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12889973
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02498194
11EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.01326074
12IRF8_22096565_ChIP-ChIP_GC-B_Human1.97683837
13AUTS2_25519132_ChIP-Seq_293T-REX_Human1.91017018
14ZNF274_21170338_ChIP-Seq_K562_Hela1.89892078
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.88478912
16ETS1_20019798_ChIP-Seq_JURKAT_Human1.84360025
17EWS_26573619_Chip-Seq_HEK293_Human1.83581354
18MYC_18940864_ChIP-ChIP_HL60_Human1.75646425
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72911909
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.71444969
21TP53_22573176_ChIP-Seq_HFKS_Human1.55437451
22GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.55272359
23CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.53898515
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.53490488
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51323816
26NANOG_20526341_ChIP-Seq_ESCs_Human1.51091618
27MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49123714
28POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45763230
29FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44956170
30FOXA1_25329375_ChIP-Seq_VCAP_Human1.44956170
31GATA3_21878914_ChIP-Seq_MCF-7_Human1.44778575
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44324080
33NCOR_22424771_ChIP-Seq_293T_Human1.42144433
34STAT1_20625510_ChIP-Seq_HELA_Human1.42023981
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41696315
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.41044341
37FUS_26573619_Chip-Seq_HEK293_Human1.40429192
38ELK1_19687146_ChIP-ChIP_HELA_Human1.37262614
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36383451
40FOXH1_21741376_ChIP-Seq_ESCs_Human1.36336094
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.35186601
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35117315
43TDRD3_21172665_ChIP-Seq_MCF-7_Human1.34606418
44TTF2_22483619_ChIP-Seq_HELA_Human1.34185844
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32955555
46VDR_23849224_ChIP-Seq_CD4+_Human1.32090454
47RNF2_27304074_Chip-Seq_NSC_Mouse1.30488256
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30212420
49SOX2_19829295_ChIP-Seq_ESCs_Human1.28483792
50NANOG_19829295_ChIP-Seq_ESCs_Human1.28483792
51FOXP3_21729870_ChIP-Seq_TREG_Human1.27386608
52ERA_21632823_ChIP-Seq_H3396_Human1.26901942
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24599719
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23991387
55FOXH1_21741376_ChIP-Seq_EPCs_Human1.23488491
56P300_19829295_ChIP-Seq_ESCs_Human1.22345013
57EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.18649269
58AR_20517297_ChIP-Seq_VCAP_Human1.18454256
59BCAT_22108803_ChIP-Seq_LS180_Human1.18206356
60GATA6_21074721_ChIP-Seq_CACO-2_Human1.17696785
61GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.15975836
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15907861
63P53_21459846_ChIP-Seq_SAOS-2_Human1.15017504
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.14104679
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14034925
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13791489
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12163396
68CDX2_22108803_ChIP-Seq_LS180_Human1.11551813
69PHF8_20622853_ChIP-Seq_HELA_Human1.09044896
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08496552
71RBPJ_21746931_ChIP-Seq_IB4_Human1.07979625
72CTCF_20526341_ChIP-Seq_ESCs_Human1.07554649
73CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.06535235
74RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06500336
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06289212
76TAF2_19829295_ChIP-Seq_ESCs_Human1.05606557
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05502902
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05344952
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02504512
80BCL6_27268052_Chip-Seq_Bcells_Human1.01022363
81ETV1_20927104_ChIP-Seq_GIST48_Human1.00081608
82NFYB_21822215_ChIP-Seq_K562_Human0.99709556
83SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99182609
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98071347
85YY1_22570637_ChIP-Seq_MALME-3M_Human0.96415736
86CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94972874
87NFYA_21822215_ChIP-Seq_K562_Human0.94578079
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94017770
89TP53_20018659_ChIP-ChIP_R1E_Mouse0.93923480
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93709645
91MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93707325
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92571424
93SA1_27219007_Chip-Seq_Bcells_Human0.92119752
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92002589
95MYC_19829295_ChIP-Seq_ESCs_Human0.91514246
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90620879
97REST_21632747_ChIP-Seq_MESCs_Mouse0.90598881
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90344685
99HNFA_21074721_ChIP-Seq_CACO-2_Human0.89821464
100CBX2_22325352_ChIP-Seq_293T-Rex_Human0.89753573

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.38769929
2MP0003878_abnormal_ear_physiology3.58828136
3MP0005377_hearing/vestibular/ear_phenot3.58828136
4MP0003787_abnormal_imprinting3.48662984
5MP0006292_abnormal_olfactory_placode3.14252889
6MP0004147_increased_porphyrin_level3.07005294
7MP0004885_abnormal_endolymph3.03672424
8MP0003011_delayed_dark_adaptation2.78738449
9MP0008877_abnormal_DNA_methylation2.75488356
10MP0004142_abnormal_muscle_tone2.65340970
11MP0003646_muscle_fatigue2.42642747
12MP0001440_abnormal_grooming_behavior2.26174012
13MP0004742_abnormal_vestibular_system2.15792189
14MP0001968_abnormal_touch/_nociception2.09443956
15MP0003300_gastrointestinal_ulcer2.03483232
16MP0006276_abnormal_autonomic_nervous1.95674196
17MP0004019_abnormal_vitamin_homeostasis1.91393962
18MP0008875_abnormal_xenobiotic_pharmacok1.89831257
19MP0002736_abnormal_nociception_after1.89209734
20MP0001986_abnormal_taste_sensitivity1.87037717
21MP0003879_abnormal_hair_cell1.84311235
22MP0006072_abnormal_retinal_apoptosis1.70856540
23MP0000015_abnormal_ear_pigmentation1.64122592
24MP0001502_abnormal_circadian_rhythm1.63127941
25MP0008872_abnormal_physiological_respon1.60294246
26MP0001853_heart_inflammation1.58712344
27MP0000427_abnormal_hair_cycle1.57317296
28MP0002095_abnormal_skin_pigmentation1.50106698
29MP0009046_muscle_twitch1.49618520
30MP0003186_abnormal_redox_activity1.48495082
31MP0006035_abnormal_mitochondrial_morpho1.47178500
32MP0003121_genomic_imprinting1.41545780
33MP0001293_anophthalmia1.38272176
34MP0001984_abnormal_olfaction1.38007995
35MP0002234_abnormal_pharynx_morphology1.31329058
36MP0003718_maternal_effect1.30595428
37MP0002272_abnormal_nervous_system1.30384175
38MP0004133_heterotaxia1.26234187
39MP0005551_abnormal_eye_electrophysiolog1.25811550
40MP0000604_amyloidosis1.25134346
41MP0001835_abnormal_antigen_presentation1.23817166
42MP0009764_decreased_sensitivity_to1.23233794
43MP0003866_abnormal_defecation1.21538273
44MP0002160_abnormal_reproductive_system1.20326199
45MP0005360_urolithiasis1.19763845
46MP0003122_maternal_imprinting1.18684012
47MP0005389_reproductive_system_phenotype1.16889320
48MP0002638_abnormal_pupillary_reflex1.15131667
49MP0002102_abnormal_ear_morphology1.14298329
50MP0009745_abnormal_behavioral_response1.14042809
51MP0004145_abnormal_muscle_electrophysio1.10804168
52MP0005671_abnormal_response_to1.10780306
53MP0003806_abnormal_nucleotide_metabolis1.05367156
54MP0002733_abnormal_thermal_nociception1.04808687
55MP0005646_abnormal_pituitary_gland1.04716074
56MP0005083_abnormal_biliary_tract1.03670129
57MP0001970_abnormal_pain_threshold1.03099870
58MP0002876_abnormal_thyroid_physiology1.01819147
59MP0000631_abnormal_neuroendocrine_gland1.01344645
60MP0000778_abnormal_nervous_system0.99570904
61MP0002557_abnormal_social/conspecific_i0.97935067
62MP0001881_abnormal_mammary_gland0.95530449
63MP0000049_abnormal_middle_ear0.94811469
64MP0002751_abnormal_autonomic_nervous0.93064688
65MP0002148_abnormal_hypersensitivity_rea0.92769067
66MP0001529_abnormal_vocalization0.91342972
67MP0005636_abnormal_mineral_homeostasis0.91228239
68MP0001905_abnormal_dopamine_level0.90496795
69MP0004924_abnormal_behavior0.86658115
70MP0005386_behavior/neurological_phenoty0.86658115
71MP0002572_abnormal_emotion/affect_behav0.86004807
72MP0000538_abnormal_urinary_bladder0.85968487
73MP0005084_abnormal_gallbladder_morpholo0.85950888
74MP0003786_premature_aging0.81271716
75MP0001324_abnormal_eye_pigmentation0.80985991
76MP0001188_hyperpigmentation0.77614119
77MP0001919_abnormal_reproductive_system0.76965295
78MP0005253_abnormal_eye_physiology0.74840486
79MP0002064_seizures0.74812311
80MP0001879_abnormal_lymphatic_vessel0.74445360
81MP0002752_abnormal_somatic_nervous0.72112110
82MP0002735_abnormal_chemical_nociception0.71804814
83MP0002734_abnormal_mechanical_nocicepti0.71532995
84MP0005410_abnormal_fertilization0.71242367
85MP0008775_abnormal_heart_ventricle0.70841258
86MP0005423_abnormal_somatic_nervous0.70311997
87MP0001664_abnormal_digestion0.68472642
88MP0008789_abnormal_olfactory_epithelium0.67694307
89MP0000026_abnormal_inner_ear0.67622973
90MP0002938_white_spotting0.66730212
91MP0002138_abnormal_hepatobiliary_system0.66413437
92MP0005332_abnormal_amino_acid0.65827966
93MP0000470_abnormal_stomach_morphology0.64524752
94MP0005195_abnormal_posterior_eye0.62549401
95MP0002229_neurodegeneration0.61726871
96MP0001485_abnormal_pinna_reflex0.61323700
97MP0000516_abnormal_urinary_system0.60977011
98MP0005367_renal/urinary_system_phenotyp0.60977011
99MP0002184_abnormal_innervation0.60808249
100MP0000230_abnormal_systemic_arterial0.60806138

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hemoglobin (HP:0011902)6.90945057
2Reticulocytopenia (HP:0001896)5.69317184
3Abnormality of cells of the erythroid lineage (HP:0012130)5.03640946
4Abnormality of the heme biosynthetic pathway (HP:0010472)4.44547424
5Pallor (HP:0000980)4.23029809
6Acute necrotizing encephalopathy (HP:0006965)4.17991431
7Keratoconus (HP:0000563)4.08643179
8Increased corneal curvature (HP:0100692)4.08643179
9Macrocytic anemia (HP:0001972)3.97245750
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.88457153
11Pancreatic fibrosis (HP:0100732)3.83919384
12Stenosis of the external auditory canal (HP:0000402)3.80963485
13Pancreatic cysts (HP:0001737)3.72035663
14Acute encephalopathy (HP:0006846)3.65150975
15Abnormality of midbrain morphology (HP:0002418)3.64625218
16Molar tooth sign on MRI (HP:0002419)3.64625218
17Progressive macrocephaly (HP:0004481)3.58677216
18Abnormal number of erythroid precursors (HP:0012131)3.55347441
19Abnormal mitochondria in muscle tissue (HP:0008316)3.52475031
20True hermaphroditism (HP:0010459)3.10435328
21Nephronophthisis (HP:0000090)3.05019240
22Pendular nystagmus (HP:0012043)3.02198487
23Abnormal rod and cone electroretinograms (HP:0008323)3.00794356
24Cystic liver disease (HP:0006706)2.96773770
25Decreased electroretinogram (ERG) amplitude (HP:0000654)2.96519096
26Decreased central vision (HP:0007663)2.90732062
27Optic disc pallor (HP:0000543)2.88700114
28Abnormality of the renal medulla (HP:0100957)2.87324776
29Elevated erythrocyte sedimentation rate (HP:0003565)2.82626723
30Type II lissencephaly (HP:0007260)2.80539102
31Mitochondrial inheritance (HP:0001427)2.78366992
32Anencephaly (HP:0002323)2.74670428
33Absent/shortened dynein arms (HP:0200106)2.73277078
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.73277078
35Focal motor seizures (HP:0011153)2.71309659
36Abnormality of the renal cortex (HP:0011035)2.69417335
37Confusion (HP:0001289)2.58676735
38Renal Fanconi syndrome (HP:0001994)2.50200641
39Congenital stationary night blindness (HP:0007642)2.48479785
40Cerebral edema (HP:0002181)2.46823493
41Increased CSF lactate (HP:0002490)2.42969457
42Abnormality of homocysteine metabolism (HP:0010919)2.33887680
43Homocystinuria (HP:0002156)2.33887680
44Osteomalacia (HP:0002749)2.31900791
45Abnormality of reticulocytes (HP:0004312)2.31337812
463-Methylglutaconic aciduria (HP:0003535)2.27788687
47Abnormal biliary tract physiology (HP:0012439)2.26803269
48Bile duct proliferation (HP:0001408)2.26803269
49Aplasia/Hypoplasia of the spleen (HP:0010451)2.26320882
50Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.25480776
51Clumsiness (HP:0002312)2.24872137
52Septo-optic dysplasia (HP:0100842)2.14601036
53Asplenia (HP:0001746)2.12844792
54Gastrointestinal infarctions (HP:0005244)2.11543114
55Abnormality of the labia minora (HP:0012880)2.07709746
56Leukodystrophy (HP:0002415)2.05946463
57Sclerocornea (HP:0000647)2.05874166
58Supernumerary spleens (HP:0009799)2.05404392
59Congenital hepatic fibrosis (HP:0002612)2.00721211
60Medial flaring of the eyebrow (HP:0010747)1.99794925
61Constricted visual fields (HP:0001133)1.98659666
62Hypoplasia of the uterus (HP:0000013)1.95156125
63Abnormal respiratory motile cilium morphology (HP:0005938)1.93739916
64Abnormal respiratory epithelium morphology (HP:0012253)1.93739916
65Colon cancer (HP:0003003)1.93261692
66Absent thumb (HP:0009777)1.91940328
67Aplasia/hypoplasia of the uterus (HP:0008684)1.88989262
68Thyroid-stimulating hormone excess (HP:0002925)1.86252336
69Depressed nasal ridge (HP:0000457)1.86251934
70Abnormality of cochlea (HP:0000375)1.86154946
71Abnormality of serum amino acid levels (HP:0003112)1.86082673
72Chorioretinal atrophy (HP:0000533)1.85636297
73Inability to walk (HP:0002540)1.84630612
74Hyperglycinemia (HP:0002154)1.84131869
75Adrenal hypoplasia (HP:0000835)1.83890980
76Chronic hepatic failure (HP:0100626)1.83765092
77Male pseudohermaphroditism (HP:0000037)1.83386245
78Optic nerve hypoplasia (HP:0000609)1.83271383
79Brushfield spots (HP:0001088)1.82705247
80Increased serum lactate (HP:0002151)1.81554298
81Enlarged kidneys (HP:0000105)1.79356914
82Stomatitis (HP:0010280)1.78792432
83Abnormality of renal resorption (HP:0011038)1.78184604
84Type 2 muscle fiber atrophy (HP:0003554)1.77934288
85Hyperglycinuria (HP:0003108)1.77025890
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74222477
87Abnormal drinking behavior (HP:0030082)1.73198264
88Polydipsia (HP:0001959)1.73198264
89Chronic bronchitis (HP:0004469)1.67694405
90Abnormality of macular pigmentation (HP:0008002)1.66857556
91Tubular atrophy (HP:0000092)1.66635748
92Tubulointerstitial fibrosis (HP:0005576)1.66333652
93Congenital, generalized hypertrichosis (HP:0004540)1.66066602
94Thrombocytosis (HP:0001894)1.64904799
95Attenuation of retinal blood vessels (HP:0007843)1.64786871
96Progressive inability to walk (HP:0002505)1.63697088
97Hyperthyroidism (HP:0000836)1.62389093
98Polyphagia (HP:0002591)1.62349167
99Abnormal ciliary motility (HP:0012262)1.61982865
100Potter facies (HP:0002009)1.60546459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.68752846
2ADRBK23.01982736
3MAP3K132.92556382
4EIF2AK12.85978792
5TAOK32.59569181
6GRK12.55503848
7WNK42.32033486
8MAP4K22.17470069
9PIK3CA2.09806160
10NUAK11.98087948
11VRK21.97632539
12PHKG21.83274899
13PHKG11.83274899
14EPHB21.74331722
15TEC1.68297153
16DYRK21.67024430
17AKT31.66377257
18IKBKB1.63974849
19CSNK1G31.63558485
20BMPR1B1.61664953
21PINK11.60815071
22CDK191.52624360
23CSNK1G21.44794067
24CSNK1G11.42763635
25TRPM71.40679511
26TIE11.32085427
27PDK21.27963512
28ZAK1.26924104
29CSNK1A1L1.25337260
30TLK11.24252343
31RPS6KB21.18837419
32ACVR1B1.14589165
33MAP3K121.10563456
34BCKDK1.09919302
35RPS6KA61.08535027
36ADRBK11.08310570
37MAP4K11.06090306
38TGFBR11.05040769
39KIT1.02154376
40OXSR10.99520370
41RPS6KC10.96686855
42RPS6KL10.96686855
43TXK0.96147163
44ITK0.91565946
45NME20.89228430
46NTRK30.86742184
47TYRO30.86418727
48PRKCQ0.83635526
49MAPK130.83425431
50CHEK20.82476799
51DAPK30.82226246
52PLK20.82067317
53BTK0.81616677
54STK110.80956590
55PRKCG0.80619199
56VRK10.79974715
57MOS0.78485414
58RPS6KA50.76284229
59LRRK20.72570046
60PRKACA0.71882439
61INSRR0.71771040
62CAMK2A0.70895717
63CAMK2D0.70168422
64MAPKAPK50.69989998
65MKNK20.69208964
66GRK70.68309402
67BRAF0.66920192
68CHUK0.66267290
69MAP3K70.65967672
70PAK60.65517404
71CSNK2A20.65273195
72PIK3CG0.64914238
73EPHA40.62013934
74RPS6KB10.61290618
75PRKCE0.59995445
76JAK30.57895492
77PRKCI0.57775780
78MAP3K110.56615889
79PRKCA0.55401952
80CASK0.55002891
81PRKG10.54420529
82PAK30.54404407
83GRK50.53523192
84MAPKAPK30.53128758
85PLK30.52988734
86OBSCN0.52103332
87PRKCZ0.51167007
88PRKCH0.50922069
89PRKCD0.49791744
90MYLK0.47323960
91CAMKK20.46072422
92MARK10.44957523
93ABL20.44709379
94MUSK0.44213918
95STK160.43208213
96SGK10.42938181
97CSNK1A10.42294789
98PRKACG0.41204836
99DYRK1A0.39741616
100SGK2230.39016615

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.26474830
2Oxidative phosphorylation_Homo sapiens_hsa001903.43064264
3One carbon pool by folate_Homo sapiens_hsa006702.91485832
4Parkinsons disease_Homo sapiens_hsa050122.77894718
5Asthma_Homo sapiens_hsa053102.49162906
6Nitrogen metabolism_Homo sapiens_hsa009102.40178692
7Cardiac muscle contraction_Homo sapiens_hsa042602.38369626
8Linoleic acid metabolism_Homo sapiens_hsa005912.15259033
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.97427328
10Phototransduction_Homo sapiens_hsa047441.91868659
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.90735865
12Alzheimers disease_Homo sapiens_hsa050101.89329714
13Huntingtons disease_Homo sapiens_hsa050161.88316056
14Caffeine metabolism_Homo sapiens_hsa002321.87247616
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87036616
16RNA polymerase_Homo sapiens_hsa030201.85724234
17Basal transcription factors_Homo sapiens_hsa030221.77739073
18Protein export_Homo sapiens_hsa030601.75974668
19RNA degradation_Homo sapiens_hsa030181.64139607
20Allograft rejection_Homo sapiens_hsa053301.63909802
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58134069
22Fat digestion and absorption_Homo sapiens_hsa049751.55011835
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53889431
24Nicotine addiction_Homo sapiens_hsa050331.53064251
25Proteasome_Homo sapiens_hsa030501.51156351
26Graft-versus-host disease_Homo sapiens_hsa053321.50889026
27Autoimmune thyroid disease_Homo sapiens_hsa053201.47974869
28Fanconi anemia pathway_Homo sapiens_hsa034601.38827746
29Mineral absorption_Homo sapiens_hsa049781.37950063
30Dorso-ventral axis formation_Homo sapiens_hsa043201.35262823
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32649106
32Chemical carcinogenesis_Homo sapiens_hsa052041.31037134
33Olfactory transduction_Homo sapiens_hsa047401.30136896
34Arachidonic acid metabolism_Homo sapiens_hsa005901.28274256
35Type I diabetes mellitus_Homo sapiens_hsa049401.21948158
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.21903895
37Ether lipid metabolism_Homo sapiens_hsa005651.19012769
38Tryptophan metabolism_Homo sapiens_hsa003801.18529941
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16598983
40Sulfur relay system_Homo sapiens_hsa041221.16209521
41Sulfur metabolism_Homo sapiens_hsa009201.16003830
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13579180
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12619005
44Retinol metabolism_Homo sapiens_hsa008301.10058182
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08358186
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04596139
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01065626
48Peroxisome_Homo sapiens_hsa041460.95898858
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91100292
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.88874074
51Hematopoietic cell lineage_Homo sapiens_hsa046400.88164733
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85098266
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84390546
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.79230106
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74473814
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74227798
57Morphine addiction_Homo sapiens_hsa050320.72209283
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69536764
59Homologous recombination_Homo sapiens_hsa034400.68628906
60Fatty acid biosynthesis_Homo sapiens_hsa000610.67718106
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61142166
62Glycerolipid metabolism_Homo sapiens_hsa005610.60763913
63Metabolic pathways_Homo sapiens_hsa011000.59912756
64Pyrimidine metabolism_Homo sapiens_hsa002400.59653841
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57505147
66Insulin secretion_Homo sapiens_hsa049110.53127345
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53059595
68Nucleotide excision repair_Homo sapiens_hsa034200.52798722
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52528944
70Butanoate metabolism_Homo sapiens_hsa006500.52355803
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.51419010
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49552272
73Fatty acid degradation_Homo sapiens_hsa000710.49424003
74Primary immunodeficiency_Homo sapiens_hsa053400.48395857
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47669723
76Rheumatoid arthritis_Homo sapiens_hsa053230.47590402
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.46599005
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45689454
79Folate biosynthesis_Homo sapiens_hsa007900.45522069
80Propanoate metabolism_Homo sapiens_hsa006400.45105522
81Ovarian steroidogenesis_Homo sapiens_hsa049130.43618692
82Antigen processing and presentation_Homo sapiens_hsa046120.43254304
83Taste transduction_Homo sapiens_hsa047420.43026925
84Tyrosine metabolism_Homo sapiens_hsa003500.42502634
85Salivary secretion_Homo sapiens_hsa049700.38776286
86Purine metabolism_Homo sapiens_hsa002300.38700008
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.37470303
88T cell receptor signaling pathway_Homo sapiens_hsa046600.36354347
89Protein digestion and absorption_Homo sapiens_hsa049740.35314320
90beta-Alanine metabolism_Homo sapiens_hsa004100.32619158
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30577064
92Vitamin digestion and absorption_Homo sapiens_hsa049770.30240928
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29510566
94Bile secretion_Homo sapiens_hsa049760.28665776
95Fatty acid elongation_Homo sapiens_hsa000620.26290328
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24655301
97Hedgehog signaling pathway_Homo sapiens_hsa043400.22736102
98Basal cell carcinoma_Homo sapiens_hsa052170.21061357
99Histidine metabolism_Homo sapiens_hsa003400.20949974
100Serotonergic synapse_Homo sapiens_hsa047260.20418488

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