RPL34P26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.74711142
2ribosomal small subunit assembly (GO:0000028)7.68782417
3translational termination (GO:0006415)7.38744802
4ribosomal small subunit biogenesis (GO:0042274)6.86124330
5maturation of SSU-rRNA (GO:0030490)6.55144460
6translational elongation (GO:0006414)6.09591153
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.06651797
8cotranslational protein targeting to membrane (GO:0006613)6.00752150
9protein targeting to ER (GO:0045047)5.93895569
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.70981799
11protein localization to endoplasmic reticulum (GO:0070972)5.56753874
12cellular protein complex disassembly (GO:0043624)5.51461274
13viral life cycle (GO:0019058)5.49837289
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.31588111
15protein neddylation (GO:0045116)4.89986899
16ATP synthesis coupled proton transport (GO:0015986)4.81346982
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.81346982
18protein complex disassembly (GO:0043241)4.70827755
19translational initiation (GO:0006413)4.66196635
20ribosomal large subunit biogenesis (GO:0042273)4.55200611
21macromolecular complex disassembly (GO:0032984)4.45236476
22cell proliferation in forebrain (GO:0021846)4.33441513
23protein complex biogenesis (GO:0070271)4.24039069
24mitochondrial respiratory chain complex I assembly (GO:0032981)4.24014920
25NADH dehydrogenase complex assembly (GO:0010257)4.24014920
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.24014920
27chaperone-mediated protein transport (GO:0072321)4.18694606
28DNA deamination (GO:0045006)4.02364041
29behavioral response to nicotine (GO:0035095)3.98119321
30protein targeting to membrane (GO:0006612)3.94394636
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.91020086
32mitochondrial respiratory chain complex assembly (GO:0033108)3.83813684
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.82312760
34negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.80768055
35nuclear-transcribed mRNA catabolic process (GO:0000956)3.79773706
36translation (GO:0006412)3.76063604
37substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.68372062
38substrate-independent telencephalic tangential migration (GO:0021826)3.68372062
39mRNA catabolic process (GO:0006402)3.58756411
40GTP biosynthetic process (GO:0006183)3.52587794
41cellular component biogenesis (GO:0044085)3.44391754
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36486263
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36486263
44cardiovascular system development (GO:0072358)3.34882154
45response to xenobiotic stimulus (GO:0009410)3.32222878
46somite development (GO:0061053)3.30581257
47water-soluble vitamin biosynthetic process (GO:0042364)3.30300328
48ribonucleoprotein complex biogenesis (GO:0022613)3.28240387
49RNA catabolic process (GO:0006401)3.28091210
50parturition (GO:0007567)3.27947621
51respiratory electron transport chain (GO:0022904)3.26821831
52electron transport chain (GO:0022900)3.26727566
53establishment of protein localization to mitochondrial membrane (GO:0090151)3.15871186
54resolution of meiotic recombination intermediates (GO:0000712)3.10261179
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.06490634
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05658820
57purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.05529584
58tongue development (GO:0043586)3.05044281
59UTP biosynthetic process (GO:0006228)3.03307147
60pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03292490
61positive regulation of T cell apoptotic process (GO:0070234)3.01445350
62negative regulation of DNA-templated transcription, elongation (GO:0032785)3.00540983
63kinetochore assembly (GO:0051382)3.00303218
64UTP metabolic process (GO:0046051)2.98525283
65purine nucleoside triphosphate biosynthetic process (GO:0009145)2.97358190
66hypothalamus development (GO:0021854)2.93468229
67ATP biosynthetic process (GO:0006754)2.90669097
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76521755
69auditory receptor cell differentiation (GO:0042491)2.74764555
70central nervous system myelination (GO:0022010)2.74512826
71axon ensheathment in central nervous system (GO:0032291)2.74512826
72platelet dense granule organization (GO:0060155)2.72802322
73pyrimidine nucleotide catabolic process (GO:0006244)2.70608353
74myoblast migration (GO:0051451)2.69842825
75positive regulation of respiratory burst (GO:0060267)2.67946415
76dentate gyrus development (GO:0021542)2.67613030
77respiratory chain complex IV assembly (GO:0008535)2.66435702
78regulation of cilium movement (GO:0003352)2.65606380
79ribonucleoside triphosphate biosynthetic process (GO:0009201)2.65011694
80rRNA metabolic process (GO:0016072)2.62247718
81rRNA processing (GO:0006364)2.61207658
82short-term memory (GO:0007614)2.60774494
83protein targeting (GO:0006605)2.60496728
84establishment of protein localization to membrane (GO:0090150)2.60018368
85protein polyglutamylation (GO:0018095)2.58136889
86kinetochore organization (GO:0051383)2.56582453
87kynurenine metabolic process (GO:0070189)2.55858400
88glycerophospholipid catabolic process (GO:0046475)2.55747522
89nonmotile primary cilium assembly (GO:0035058)2.55344904
90pseudouridine synthesis (GO:0001522)2.54557728
91base-excision repair, AP site formation (GO:0006285)2.54550386
92neuron fate determination (GO:0048664)2.51946673
93pyrimidine nucleobase catabolic process (GO:0006208)2.51773881
94epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.49172378
95positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.48183721
96peptidyl-histidine modification (GO:0018202)2.47056203
97establishment of protein localization to organelle (GO:0072594)2.43257729
98replication fork processing (GO:0031297)2.42382680
99synaptic transmission, cholinergic (GO:0007271)2.42003190
100negative regulation of telomere maintenance (GO:0032205)2.41609032

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.41491032
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.27728084
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.24218501
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.92068079
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64941084
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.50491937
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.41656301
8IRF1_19129219_ChIP-ChIP_H3396_Human2.29178900
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18415628
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13255977
11VDR_22108803_ChIP-Seq_LS180_Human2.06850839
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.05871029
13ZNF274_21170338_ChIP-Seq_K562_Hela2.03997732
14MYC_18940864_ChIP-ChIP_HL60_Human1.97860345
15MYC_18555785_ChIP-Seq_MESCs_Mouse1.89340498
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87818279
17CBX2_27304074_Chip-Seq_ESCs_Mouse1.86730369
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.83247872
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81526698
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.75908067
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75842769
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72768906
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67307899
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66034073
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65181245
26CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61403270
27REST_21632747_ChIP-Seq_MESCs_Mouse1.59839304
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.55910989
29CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.54388585
30SRY_22984422_ChIP-ChIP_TESTIS_Rat1.52719282
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50239691
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43249336
33CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42214744
34RNF2_27304074_Chip-Seq_NSC_Mouse1.41891010
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.41659898
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.39738750
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38896136
38TTF2_22483619_ChIP-Seq_HELA_Human1.37541797
39SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36951016
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34277527
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33742364
42TP53_22573176_ChIP-Seq_HFKS_Human1.33010566
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.32419255
44GATA3_21878914_ChIP-Seq_MCF-7_Human1.31457795
45VDR_23849224_ChIP-Seq_CD4+_Human1.30888835
46TP53_20018659_ChIP-ChIP_R1E_Mouse1.30758736
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28477244
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27601062
49NANOG_20526341_ChIP-Seq_ESCs_Human1.27348362
50ERA_21632823_ChIP-Seq_H3396_Human1.26347201
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.25045134
52TAF2_19829295_ChIP-Seq_ESCs_Human1.22508544
53XRN2_22483619_ChIP-Seq_HELA_Human1.21466311
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21344711
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20747962
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18620972
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.17984079
58BCL6_27268052_Chip-Seq_Bcells_Human1.17983666
59FOXP3_21729870_ChIP-Seq_TREG_Human1.17437998
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.17301406
61CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16395810
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16176794
63NCOR_22424771_ChIP-Seq_293T_Human1.14807068
64EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14300125
65RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14300125
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10995822
67EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10983249
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09796671
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09788079
70CTCF_20526341_ChIP-Seq_ESCs_Human1.09518670
71GABP_19822575_ChIP-Seq_HepG2_Human1.09389663
72YY1_22570637_ChIP-Seq_MALME-3M_Human1.08946561
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08755582
74CTCF_27219007_Chip-Seq_Bcells_Human1.07011823
75ELK1_19687146_ChIP-ChIP_HELA_Human1.06544229
76MYC_19829295_ChIP-Seq_ESCs_Human1.05751379
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05421908
78P53_21459846_ChIP-Seq_SAOS-2_Human1.04072627
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01927812
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.00903979
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.00721945
82AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00059374
83CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99777815
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.96690551
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96690551
86MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96486240
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95561833
88SA1_27219007_Chip-Seq_Bcells_Human0.94721195
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94577688
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93667866
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91331435
92THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90723694
93FUS_26573619_Chip-Seq_HEK293_Human0.90087936
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90055578
95IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89294716
96EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89089412
97TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88704443
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.88147811
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88043852
100AR_20517297_ChIP-Seq_VCAP_Human0.87160150

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.91972199
2MP0009379_abnormal_foot_pigmentation5.70234677
3MP0003787_abnormal_imprinting3.10693610
4MP0002163_abnormal_gland_morphology2.39131314
5MP0008877_abnormal_DNA_methylation2.21659534
6MP0008789_abnormal_olfactory_epithelium2.09316764
7MP0001293_anophthalmia2.02736938
8MP0003123_paternal_imprinting1.93726324
9MP0006276_abnormal_autonomic_nervous1.91833628
10MP0002653_abnormal_ependyma_morphology1.88885161
11MP0001968_abnormal_touch/_nociception1.88174884
12MP0002837_dystrophic_cardiac_calcinosis1.77386409
13MP0002138_abnormal_hepatobiliary_system1.72108198
14MP0005423_abnormal_somatic_nervous1.71432465
15MP0003646_muscle_fatigue1.69598542
16MP0001986_abnormal_taste_sensitivity1.69284265
17MP0000049_abnormal_middle_ear1.68772441
18MP0002638_abnormal_pupillary_reflex1.68335894
19MP0005646_abnormal_pituitary_gland1.67146881
20MP0005394_taste/olfaction_phenotype1.66901484
21MP0005499_abnormal_olfactory_system1.66901484
22MP0004142_abnormal_muscle_tone1.66199713
23MP0003121_genomic_imprinting1.65581164
24MP0004885_abnormal_endolymph1.63955295
25MP0006072_abnormal_retinal_apoptosis1.63483829
26MP0008875_abnormal_xenobiotic_pharmacok1.62783180
27MP0002736_abnormal_nociception_after1.60579600
28MP0000778_abnormal_nervous_system1.59051686
29MP0003122_maternal_imprinting1.57179284
30MP0001905_abnormal_dopamine_level1.48314803
31MP0003878_abnormal_ear_physiology1.47338717
32MP0005377_hearing/vestibular/ear_phenot1.47338717
33MP0002938_white_spotting1.47128979
34MP0002272_abnormal_nervous_system1.46081240
35MP0005551_abnormal_eye_electrophysiolog1.45985520
36MP0005379_endocrine/exocrine_gland_phen1.44393668
37MP0008775_abnormal_heart_ventricle1.42515326
38MP0002234_abnormal_pharynx_morphology1.40204076
39MP0000631_abnormal_neuroendocrine_gland1.37403079
40MP0008872_abnormal_physiological_respon1.37115007
41MP0001485_abnormal_pinna_reflex1.32756916
42MP0003011_delayed_dark_adaptation1.31732114
43MP0009745_abnormal_behavioral_response1.30632950
44MP0009053_abnormal_anal_canal1.29844915
45MP0002733_abnormal_thermal_nociception1.29246740
46MP0002557_abnormal_social/conspecific_i1.29089448
47MP0002184_abnormal_innervation1.27561770
48MP0003880_abnormal_central_pattern1.26447568
49MP0003938_abnormal_ear_development1.25133117
50MP0005195_abnormal_posterior_eye1.23454366
51MP0003186_abnormal_redox_activity1.21178890
52MP0004147_increased_porphyrin_level1.18712611
53MP0004145_abnormal_muscle_electrophysio1.16809792
54MP0005084_abnormal_gallbladder_morpholo1.16010396
55MP0004742_abnormal_vestibular_system1.14963929
56MP0002752_abnormal_somatic_nervous1.14457733
57MP0001970_abnormal_pain_threshold1.12807778
58MP0000026_abnormal_inner_ear1.12234616
59MP0000955_abnormal_spinal_cord1.11856702
60MP0001486_abnormal_startle_reflex1.10587290
61MP0002572_abnormal_emotion/affect_behav1.10483160
62MP0002095_abnormal_skin_pigmentation1.09278225
63MP0010030_abnormal_orbit_morphology1.09025772
64MP0005645_abnormal_hypothalamus_physiol1.08898782
65MP0002063_abnormal_learning/memory/cond1.08552003
66MP0002160_abnormal_reproductive_system1.02660467
67MP0000427_abnormal_hair_cycle1.02660396
68MP0000372_irregular_coat_pigmentation1.02638861
69MP0000566_synostosis0.98659340
70MP0002102_abnormal_ear_morphology0.96647027
71MP0001440_abnormal_grooming_behavior0.96508875
72MP0004133_heterotaxia0.96470636
73MP0001286_abnormal_eye_development0.92909699
74MP0001963_abnormal_hearing_physiology0.89952496
75MP0009046_muscle_twitch0.88378363
76MP0001502_abnormal_circadian_rhythm0.88310743
77MP0003635_abnormal_synaptic_transmissio0.88303423
78MP0005389_reproductive_system_phenotype0.88290577
79MP0001188_hyperpigmentation0.88233660
80MP0002735_abnormal_chemical_nociception0.87517089
81MP0003879_abnormal_hair_cell0.83313170
82MP0003567_abnormal_fetal_cardiomyocyte0.82420363
83MP0002233_abnormal_nose_morphology0.82148818
84MP0002067_abnormal_sensory_capabilities0.80490765
85MP0002882_abnormal_neuron_morphology0.77747942
86MP0005253_abnormal_eye_physiology0.77180519
87MP0001529_abnormal_vocalization0.76654865
88MP0003937_abnormal_limbs/digits/tail_de0.76081264
89MP0008995_early_reproductive_senescence0.75612978
90MP0009764_decreased_sensitivity_to0.74625392
91MP0002210_abnormal_sex_determination0.74380508
92MP0000230_abnormal_systemic_arterial0.74122673
93MP0004859_abnormal_synaptic_plasticity0.73313768
94MP0002734_abnormal_mechanical_nocicepti0.73290426
95MP0001984_abnormal_olfaction0.72772884
96MP0001348_abnormal_lacrimal_gland0.71674472
97MP0005075_abnormal_melanosome_morpholog0.71566911
98MP0000613_abnormal_salivary_gland0.71433578
99MP0002249_abnormal_larynx_morphology0.71168984
100MP0001542_abnormal_bone_strength0.70270223

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.26633521
2Abnormality of cells of the erythroid lineage (HP:0012130)5.20930747
3Acute necrotizing encephalopathy (HP:0006965)4.22423348
4Pancreatic fibrosis (HP:0100732)4.15315443
5Abnormal number of erythroid precursors (HP:0012131)4.04079729
6Abnormal mitochondria in muscle tissue (HP:0008316)3.76276646
7Nephronophthisis (HP:0000090)3.66261068
8Macrocytic anemia (HP:0001972)3.62591467
9Acute encephalopathy (HP:0006846)3.61975625
10Pancreatic cysts (HP:0001737)3.49652974
11Molar tooth sign on MRI (HP:0002419)3.45391846
12Abnormality of midbrain morphology (HP:0002418)3.45391846
13Progressive macrocephaly (HP:0004481)3.42931743
14True hermaphroditism (HP:0010459)3.23758862
15Mitochondrial inheritance (HP:0001427)3.22250225
16Septo-optic dysplasia (HP:0100842)3.15447530
17Pendular nystagmus (HP:0012043)3.08687489
18Pallor (HP:0000980)2.96581341
19Abnormality of the renal medulla (HP:0100957)2.92745752
20Increased CSF lactate (HP:0002490)2.91600822
21Sclerocornea (HP:0000647)2.84809772
22Absent rod-and cone-mediated responses on ERG (HP:0007688)2.76685644
23Medial flaring of the eyebrow (HP:0010747)2.69342767
24Congenital stationary night blindness (HP:0007642)2.69306857
25Adrenal hypoplasia (HP:0000835)2.69051297
26Hyperglycinemia (HP:0002154)2.65545280
27Asplenia (HP:0001746)2.65405537
28Absent thumb (HP:0009777)2.63688695
29Stenosis of the external auditory canal (HP:0000402)2.63251426
30Aplasia/Hypoplasia of the spleen (HP:0010451)2.62711477
31Abnormal rod and cone electroretinograms (HP:0008323)2.62015902
32Cerebral edema (HP:0002181)2.57767775
33Rib fusion (HP:0000902)2.55856638
34Colon cancer (HP:0003003)2.49560135
35Anencephaly (HP:0002323)2.42204299
36Myokymia (HP:0002411)2.39570086
37Cystic liver disease (HP:0006706)2.37982721
38Abolished electroretinogram (ERG) (HP:0000550)2.36317757
39Optic disc pallor (HP:0000543)2.35773198
403-Methylglutaconic aciduria (HP:0003535)2.32761092
41Decreased electroretinogram (ERG) amplitude (HP:0000654)2.29008699
42Hepatocellular necrosis (HP:0001404)2.26592479
43Tubular atrophy (HP:0000092)2.24371787
44Depressed nasal ridge (HP:0000457)2.22429838
45Postaxial foot polydactyly (HP:0001830)2.22185719
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16890506
47Gait imbalance (HP:0002141)2.16477035
48Anophthalmia (HP:0000528)2.15565110
49Maternal diabetes (HP:0009800)2.14685010
50Type 2 muscle fiber atrophy (HP:0003554)2.13552964
51Congenital primary aphakia (HP:0007707)2.13018342
52Optic nerve hypoplasia (HP:0000609)2.12560472
53Nephrogenic diabetes insipidus (HP:0009806)2.09773770
54Hypoplasia of the ulna (HP:0003022)2.09074256
55Agitation (HP:0000713)2.08556828
56Chronic hepatic failure (HP:0100626)2.03736810
57Leukodystrophy (HP:0002415)2.03281537
58Renal dysplasia (HP:0000110)2.03273507
59Growth hormone deficiency (HP:0000824)2.02869349
60Abnormality of DNA repair (HP:0003254)2.02119147
61Congenital hepatic fibrosis (HP:0002612)2.01516542
62Absent/shortened dynein arms (HP:0200106)2.01464290
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.01464290
64Increased hepatocellular lipid droplets (HP:0006565)1.99911333
65Increased serum lactate (HP:0002151)1.99330284
66Occipital encephalocele (HP:0002085)1.98991388
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96019774
68Lipid accumulation in hepatocytes (HP:0006561)1.94384308
69Muscle fiber atrophy (HP:0100295)1.92227435
70Abnormality of the phalanges of the 5th finger (HP:0004213)1.91242712
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90288282
72Abnormality of alanine metabolism (HP:0010916)1.90288282
73Hyperalaninemia (HP:0003348)1.90288282
74Hypoplasia of the radius (HP:0002984)1.90253003
75Abnormal number of incisors (HP:0011064)1.89969495
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.88802638
77Type II lissencephaly (HP:0007260)1.86852424
78Renal Fanconi syndrome (HP:0001994)1.85771278
79Absent septum pellucidum (HP:0001331)1.85705218
80Abnormality of the renal cortex (HP:0011035)1.84803390
81Hepatic necrosis (HP:0002605)1.84158830
82Hyperthyroidism (HP:0000836)1.82856743
83Oligodactyly (HP:0012165)1.82737918
84Lactic acidosis (HP:0003128)1.82229358
85Increased corneal curvature (HP:0100692)1.81649770
86Keratoconus (HP:0000563)1.81649770
87Thyroid-stimulating hormone excess (HP:0002925)1.81173598
88Congenital, generalized hypertrichosis (HP:0004540)1.80246765
89Abnormal respiratory epithelium morphology (HP:0012253)1.78241464
90Abnormal respiratory motile cilium morphology (HP:0005938)1.78241464
91Stomatitis (HP:0010280)1.78207353
92Forearm undergrowth (HP:0009821)1.78132067
93Porencephaly (HP:0002132)1.77641710
94Decreased central vision (HP:0007663)1.75136151
95Preaxial hand polydactyly (HP:0001177)1.74623670
96Aplasia/Hypoplasia of the ulna (HP:0006495)1.74539679
97Abnormality of the nasal septum (HP:0000419)1.74536747
98Vaginal atresia (HP:0000148)1.72160170
99Male pseudohermaphroditism (HP:0000037)1.71969226
100Abnormality of the proximal phalanges of the hand (HP:0009834)1.71872908

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.61154712
2PIK3CA2.89775209
3NUAK12.75995729
4ADRBK22.66901274
5BCKDK2.62825537
6CDK192.56707018
7DYRK22.45016598
8WNK42.40552305
9NTRK22.18752360
10VRK22.18571563
11PINK11.98734352
12TXK1.94810255
13GRK11.94592864
14MAP4K21.92638080
15TAOK31.83565744
16TAF11.77343363
17TIE11.73315077
18ZAK1.73228909
19FRK1.65239769
20EPHB21.47707267
21TLK11.47686402
22BMPR1B1.37200612
23MAP3K111.36517931
24EPHA41.36042668
25PRKCG1.29931629
26NME21.25302199
27WNK31.16425820
28SIK21.14293020
29DYRK1B1.12872898
30CDC71.10254311
31CAMK11.09056067
32IKBKB1.04407001
33VRK11.02441564
34ITK1.02007739
35DAPK31.01900572
36BTK0.99481670
37ADRBK10.98102408
38SMG10.96988780
39LRRK20.95118132
40TEC0.91627073
41ABL20.91433462
42MAP3K120.89657977
43OXSR10.88102052
44CSNK1G20.87818285
45MAP3K40.87335760
46PHKG20.86429346
47PHKG10.86429346
48TYRO30.85288831
49CSNK1G30.84071757
50MAPKAPK50.81507652
51NEK20.81405782
52MAP2K70.81104242
53GRK50.80716231
54NTRK30.79754042
55MAP4K10.78789724
56DYRK30.78629154
57STK110.77761981
58RPS6KA60.75788662
59MAP3K90.73874950
60PRKCQ0.73123685
61PASK0.72587962
62RPS6KA50.67734994
63PRKACA0.66854590
64PAK30.65972800
65CAMKK20.64964692
66INSRR0.64447082
67CSNK2A20.63388466
68STK390.62637130
69CSNK1A1L0.62458440
70PRKCH0.62201579
71CSNK1G10.62018041
72PLK40.61430803
73CASK0.60245143
74MAPK130.59269640
75PRKCZ0.56192626
76PRKCE0.55374345
77AURKA0.54889217
78AURKB0.53310718
79DMPK0.52647593
80RPS6KC10.52390390
81RPS6KL10.52390390
82DYRK1A0.51779808
83ARAF0.49538989
84PLK20.48891458
85MUSK0.48575966
86PRKCD0.46828620
87PRKCA0.46669591
88WNK10.46500183
89RPS6KA10.44719487
90NTRK10.44568154
91TNK20.43856740
92PLK10.43156930
93CAMKK10.43149605
94CHUK0.41963962
95PKN10.41801878
96OBSCN0.41592466
97PRKCI0.40840841
98CHEK20.40592672
99BRAF0.40327672
100ATR0.40225897

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.66294766
2Oxidative phosphorylation_Homo sapiens_hsa001903.82087542
3Parkinsons disease_Homo sapiens_hsa050123.13845846
4Asthma_Homo sapiens_hsa053102.49228588
5Cardiac muscle contraction_Homo sapiens_hsa042602.39447298
6Sulfur relay system_Homo sapiens_hsa041222.22956665
7Linoleic acid metabolism_Homo sapiens_hsa005912.21773474
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19077410
9Huntingtons disease_Homo sapiens_hsa050162.18051898
10Alzheimers disease_Homo sapiens_hsa050102.11569739
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02001729
12RNA polymerase_Homo sapiens_hsa030201.98606922
13Homologous recombination_Homo sapiens_hsa034401.97558993
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.96633745
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.95710440
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.95708259
17Allograft rejection_Homo sapiens_hsa053301.74987181
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67545741
19Phototransduction_Homo sapiens_hsa047441.65691960
20Fanconi anemia pathway_Homo sapiens_hsa034601.63239165
21Autoimmune thyroid disease_Homo sapiens_hsa053201.62334581
22Protein export_Homo sapiens_hsa030601.52057973
23One carbon pool by folate_Homo sapiens_hsa006701.50154420
24RNA degradation_Homo sapiens_hsa030181.44058963
25Basal transcription factors_Homo sapiens_hsa030221.29164416
26Arachidonic acid metabolism_Homo sapiens_hsa005901.23907082
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18727483
28Caffeine metabolism_Homo sapiens_hsa002321.17195113
29Graft-versus-host disease_Homo sapiens_hsa053321.14554567
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10671522
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09219820
32Mismatch repair_Homo sapiens_hsa034301.08869464
33Proteasome_Homo sapiens_hsa030501.08354402
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.06765370
35Pyrimidine metabolism_Homo sapiens_hsa002401.03881820
36Type I diabetes mellitus_Homo sapiens_hsa049401.01212092
37Butanoate metabolism_Homo sapiens_hsa006501.00489465
38Olfactory transduction_Homo sapiens_hsa047400.99984042
39Ether lipid metabolism_Homo sapiens_hsa005650.96832179
40Fat digestion and absorption_Homo sapiens_hsa049750.96665153
41Basal cell carcinoma_Homo sapiens_hsa052170.96355535
42Primary immunodeficiency_Homo sapiens_hsa053400.94141012
43Peroxisome_Homo sapiens_hsa041460.90531499
44Nucleotide excision repair_Homo sapiens_hsa034200.90336311
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90067882
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87385342
47Nicotine addiction_Homo sapiens_hsa050330.84045885
48Sulfur metabolism_Homo sapiens_hsa009200.83769292
49Retinol metabolism_Homo sapiens_hsa008300.82847430
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81911695
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80768256
52Hedgehog signaling pathway_Homo sapiens_hsa043400.77659397
53Selenocompound metabolism_Homo sapiens_hsa004500.75571104
54Tryptophan metabolism_Homo sapiens_hsa003800.74001615
55Nitrogen metabolism_Homo sapiens_hsa009100.72964486
56Morphine addiction_Homo sapiens_hsa050320.71500729
57Purine metabolism_Homo sapiens_hsa002300.66261941
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.65977970
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.65552354
60Chemical carcinogenesis_Homo sapiens_hsa052040.65474367
61Metabolic pathways_Homo sapiens_hsa011000.64120715
62Insulin secretion_Homo sapiens_hsa049110.63883332
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63618297
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63211639
65Propanoate metabolism_Homo sapiens_hsa006400.62636792
66Ovarian steroidogenesis_Homo sapiens_hsa049130.60786037
67Collecting duct acid secretion_Homo sapiens_hsa049660.60404186
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59869735
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59560849
70DNA replication_Homo sapiens_hsa030300.57466816
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56984857
72RNA transport_Homo sapiens_hsa030130.53930741
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.53180127
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52364495
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51999410
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50478205
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49663634
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49008327
79Rheumatoid arthritis_Homo sapiens_hsa053230.48511267
80Spliceosome_Homo sapiens_hsa030400.46083377
81Vitamin B6 metabolism_Homo sapiens_hsa007500.45396620
82Steroid biosynthesis_Homo sapiens_hsa001000.45108729
83Base excision repair_Homo sapiens_hsa034100.44741829
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44103638
85Salivary secretion_Homo sapiens_hsa049700.43429809
86Glycerolipid metabolism_Homo sapiens_hsa005610.39850831
87Serotonergic synapse_Homo sapiens_hsa047260.38189987
88Regulation of autophagy_Homo sapiens_hsa041400.36080452
89Fatty acid biosynthesis_Homo sapiens_hsa000610.35882953
90Taste transduction_Homo sapiens_hsa047420.34886823
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34715535
92Glutathione metabolism_Homo sapiens_hsa004800.34227761
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33788496
94p53 signaling pathway_Homo sapiens_hsa041150.31129469
95Notch signaling pathway_Homo sapiens_hsa043300.29137327
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28288618
97GABAergic synapse_Homo sapiens_hsa047270.26863858
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25747490
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24610041
100Glutamatergic synapse_Homo sapiens_hsa047240.23463023

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