RPL34P27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)7.35390846
2cytidine catabolic process (GO:0006216)7.35390846
3cytidine deamination (GO:0009972)7.35390846
4DNA deamination (GO:0045006)7.21820599
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.15184198
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.46267688
7ribosomal small subunit assembly (GO:0000028)4.69783049
8Arp2/3 complex-mediated actin nucleation (GO:0034314)4.50487338
9negative T cell selection (GO:0043383)4.40279105
10positive T cell selection (GO:0043368)4.38714860
11positive thymic T cell selection (GO:0045059)4.31889036
12actin nucleation (GO:0045010)4.18363447
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.13072569
14cellular response to interleukin-15 (GO:0071350)3.93869801
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.89012066
16T cell migration (GO:0072678)3.87019535
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86395583
18ATP synthesis coupled proton transport (GO:0015986)3.86395583
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.85477064
20positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.82765603
21positive regulation of natural killer cell mediated immunity (GO:0002717)3.82710894
22positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.80343651
23positive regulation of calcium-mediated signaling (GO:0050850)3.74578773
24sequestering of actin monomers (GO:0042989)3.73440909
25regulation of leukocyte mediated cytotoxicity (GO:0001910)3.63061883
26negative regulation of T cell apoptotic process (GO:0070233)3.61957765
27negative thymic T cell selection (GO:0045060)3.58296674
28regulation of activation of Janus kinase activity (GO:0010533)3.57973363
29positive regulation of T cell mediated cytotoxicity (GO:0001916)3.57860957
30regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.53064553
31regulation of natural killer cell mediated immunity (GO:0002715)3.53064553
32positive regulation of defense response to virus by host (GO:0002230)3.48509344
33regulation of B cell receptor signaling pathway (GO:0050855)3.48433103
34pyrimidine nucleoside catabolic process (GO:0046135)3.47656369
35positive regulation of cell killing (GO:0031343)3.44397498
36viral transcription (GO:0019083)3.42238083
37regulation of T cell mediated cytotoxicity (GO:0001914)3.38512526
38mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38257591
39regulation of regulatory T cell differentiation (GO:0045589)3.37066527
40thymic T cell selection (GO:0045061)3.36995769
41regulation of T cell receptor signaling pathway (GO:0050856)3.31336274
42regulation of cell killing (GO:0031341)3.31207677
43behavioral response to nicotine (GO:0035095)3.25514700
44translational termination (GO:0006415)3.24111623
45T cell receptor signaling pathway (GO:0050852)3.22869096
46respiratory electron transport chain (GO:0022904)3.15990273
47response to pheromone (GO:0019236)3.14978238
48cytolysis (GO:0019835)3.13556288
49electron transport chain (GO:0022900)3.13449212
50positive regulation of interleukin-8 secretion (GO:2000484)3.13140359
51mast cell activation (GO:0045576)3.08002738
52platelet dense granule organization (GO:0060155)3.03930846
53negative regulation by host of viral transcription (GO:0043922)3.03777699
54regulation of interleukin-8 secretion (GO:2000482)3.03046055
55regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.03038955
56regulation of T cell tolerance induction (GO:0002664)3.02721127
57negative regulation of viral genome replication (GO:0045071)3.02693904
58response to interferon-beta (GO:0035456)3.02180310
59translational elongation (GO:0006414)3.02061486
60maturation of SSU-rRNA (GO:0030490)2.99648856
61positive regulation of tolerance induction (GO:0002645)2.98540572
62protein neddylation (GO:0045116)2.96757081
63T cell selection (GO:0045058)2.96206094
64SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.95163848
65protein targeting to ER (GO:0045047)2.93687839
66positive regulation of gamma-delta T cell activation (GO:0046645)2.93562053
67positive regulation of B cell differentiation (GO:0045579)2.91724922
68cotranslational protein targeting to membrane (GO:0006613)2.89978753
69response to interleukin-15 (GO:0070672)2.84097539
70iron-sulfur cluster assembly (GO:0016226)2.81840968
71metallo-sulfur cluster assembly (GO:0031163)2.81840968
72regulation of gamma-delta T cell differentiation (GO:0045586)2.79655694
73negative regulation of cell killing (GO:0031342)2.79540574
74negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.79540574
75protein localization to endoplasmic reticulum (GO:0070972)2.79441066
76establishment of protein localization to endoplasmic reticulum (GO:0072599)2.78166841
77regulation of chronic inflammatory response (GO:0002676)2.77174311
78interferon-gamma production (GO:0032609)2.76820272
79T cell costimulation (GO:0031295)2.75662986
80lymphocyte costimulation (GO:0031294)2.73503207
81regulation of calcium-mediated signaling (GO:0050848)2.72891876
82positive regulation of alpha-beta T cell proliferation (GO:0046641)2.72715483
83regulation of T cell apoptotic process (GO:0070232)2.71263439
84positive regulation of prostaglandin secretion (GO:0032308)2.70800910
85negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.69722742
86tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69485375
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69485375
88antigen receptor-mediated signaling pathway (GO:0050851)2.69460497
89kynurenine metabolic process (GO:0070189)2.68033255
90positive regulation of T cell apoptotic process (GO:0070234)2.67538632
91negative regulation of lymphocyte apoptotic process (GO:0070229)2.67400327
92mast cell activation involved in immune response (GO:0002279)2.66754484
93mast cell degranulation (GO:0043303)2.66754484
94positive regulation of uterine smooth muscle contraction (GO:0070474)2.66703821
95GPI anchor metabolic process (GO:0006505)2.65341251
96eosinophil chemotaxis (GO:0048245)2.64599139
97regulation of alpha-beta T cell proliferation (GO:0046640)2.62928646
98DNA demethylation (GO:0080111)2.61579827
99GPI anchor biosynthetic process (GO:0006506)2.61364298
100regulation of isotype switching to IgG isotypes (GO:0048302)2.60329395

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.05121547
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.76265881
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.53559844
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.46119084
5EZH2_22144423_ChIP-Seq_EOC_Human3.32581473
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.81626223
7VDR_22108803_ChIP-Seq_LS180_Human2.75026127
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63965248
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56762769
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.40470497
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.23993393
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17447484
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13497039
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.06679712
15ZNF274_21170338_ChIP-Seq_K562_Hela2.02056988
16MYB_26560356_Chip-Seq_TH2_Human1.97316176
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95570233
18RUNX_20019798_ChIP-Seq_JUKART_Human1.92938807
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89594190
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.89164080
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.80136167
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75194657
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73181145
24GATA3_26560356_Chip-Seq_TH2_Human1.66838115
25VDR_23849224_ChIP-Seq_CD4+_Human1.63840958
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.61577630
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.60608550
28GATA3_27048872_Chip-Seq_THYMUS_Human1.58354045
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52541789
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48323820
31RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47080738
32EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.46685734
33TP53_22573176_ChIP-Seq_HFKS_Human1.40492916
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39646456
35NANOG_20526341_ChIP-Seq_ESCs_Human1.38219374
36PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.38118884
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37894983
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36686696
39IGF1R_20145208_ChIP-Seq_DFB_Human1.36093789
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35412496
41AR_20517297_ChIP-Seq_VCAP_Human1.34132586
42TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.33460024
43MYC_18940864_ChIP-ChIP_HL60_Human1.33246321
44TAF2_19829295_ChIP-Seq_ESCs_Human1.32085166
45BCL6_27268052_Chip-Seq_Bcells_Human1.31622201
46NCOR_22424771_ChIP-Seq_293T_Human1.30422549
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29571969
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28168688
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28108333
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25860138
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.25860138
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25613327
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.23939005
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.22365564
55CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.21162657
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18113333
57MYC_19829295_ChIP-Seq_ESCs_Human1.17953613
58FOXP3_21729870_ChIP-Seq_TREG_Human1.17386532
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16621047
60MYB_26560356_Chip-Seq_TH1_Human1.15482111
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14606085
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13383824
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13330017
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12438333
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.10526473
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10190493
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09662366
68ER_23166858_ChIP-Seq_MCF-7_Human1.09137371
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08920776
70CTCF_20526341_ChIP-Seq_ESCs_Human1.07928843
71UTX_26944678_Chip-Seq_JUKART_Human1.07137907
72FOXH1_21741376_ChIP-Seq_EPCs_Human1.06338702
73ERA_21632823_ChIP-Seq_H3396_Human1.06062348
74NANOG_19829295_ChIP-Seq_ESCs_Human1.04182999
75SOX2_19829295_ChIP-Seq_ESCs_Human1.04182999
76HTT_18923047_ChIP-ChIP_STHdh_Human1.03130437
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02442964
78CBP_20019798_ChIP-Seq_JUKART_Human1.02442964
79FOXH1_21741376_ChIP-Seq_ESCs_Human1.01079579
80P300_27268052_Chip-Seq_Bcells_Human1.00597124
81ERG_20517297_ChIP-Seq_VCAP_Human0.99909148
82YY1_22570637_ChIP-Seq_MALME-3M_Human0.99692015
83RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98952996
84JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98038840
85BCAT_22108803_ChIP-Seq_LS180_Human0.97288253
86OCT4_20526341_ChIP-Seq_ESCs_Human0.96586587
87MAF_26560356_Chip-Seq_TH2_Human0.96571168
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.96490465
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95717487
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95226022
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94926906
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94386860
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94354209
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94002655
95EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93943807
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93746272
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91930816
98GATA6_21074721_ChIP-Seq_CACO-2_Human0.90322032
99SA1_27219007_Chip-Seq_Bcells_Human0.90277222
100E2F1_20622854_ChIP-Seq_HELA_Human0.90081980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.65280585
2MP0009785_altered_susceptibility_to2.86574997
3MP0001835_abnormal_antigen_presentation2.66229867
4MP0003763_abnormal_thymus_physiology2.57523983
5MP0003646_muscle_fatigue2.39566469
6MP0005000_abnormal_immune_tolerance2.22353209
7MP0009379_abnormal_foot_pigmentation2.22162086
8MP0001800_abnormal_humoral_immune2.21137722
9MP0002102_abnormal_ear_morphology2.11531114
10MP0006292_abnormal_olfactory_placode2.07040179
11MP0000685_abnormal_immune_system2.05753859
12MP0009333_abnormal_splenocyte_physiolog2.05460213
13MP0002166_altered_tumor_susceptibility1.97209204
14MP0002723_abnormal_immune_serum1.95988517
15MP0005025_abnormal_response_to1.92765361
16MP0005377_hearing/vestibular/ear_phenot1.92418224
17MP0003878_abnormal_ear_physiology1.92418224
18MP0002420_abnormal_adaptive_immunity1.92220510
19MP0001819_abnormal_immune_cell1.87335914
20MP0002148_abnormal_hypersensitivity_rea1.87145634
21MP0005645_abnormal_hypothalamus_physiol1.82979179
22MP0008877_abnormal_DNA_methylation1.78682696
23MP0003866_abnormal_defecation1.75797143
24MP0001790_abnormal_immune_system1.73978025
25MP0005387_immune_system_phenotype1.73978025
26MP0006072_abnormal_retinal_apoptosis1.73668281
27MP0008872_abnormal_physiological_respon1.69836679
28MP0003787_abnormal_imprinting1.68403365
29MP0005551_abnormal_eye_electrophysiolog1.66411009
30MP0002163_abnormal_gland_morphology1.63364397
31MP0003724_increased_susceptibility_to1.61809939
32MP0002452_abnormal_antigen_presenting1.59978625
33MP0002876_abnormal_thyroid_physiology1.59194555
34MP0001919_abnormal_reproductive_system1.56538191
35MP0004145_abnormal_muscle_electrophysio1.54394980
36MP0001873_stomach_inflammation1.51830203
37MP0000372_irregular_coat_pigmentation1.51768910
38MP0002837_dystrophic_cardiac_calcinosis1.50331870
39MP0005646_abnormal_pituitary_gland1.50047597
40MP0002006_tumorigenesis1.48907270
41MP0005075_abnormal_melanosome_morpholog1.46377323
42MP0004885_abnormal_endolymph1.44822977
43MP0001968_abnormal_touch/_nociception1.42712482
44MP0002138_abnormal_hepatobiliary_system1.41618825
45MP0000716_abnormal_immune_system1.40626863
46MP0003011_delayed_dark_adaptation1.39569193
47MP0005389_reproductive_system_phenotype1.38845430
48MP0004147_increased_porphyrin_level1.38697829
49MP0001905_abnormal_dopamine_level1.36216113
50MP0008875_abnormal_xenobiotic_pharmacok1.35893673
51MP0002736_abnormal_nociception_after1.34413231
52MP0003436_decreased_susceptibility_to1.33475843
53MP0002933_joint_inflammation1.33203294
54MP0002398_abnormal_bone_marrow1.32688403
55MP0002405_respiratory_system_inflammati1.32586225
56MP0002277_abnormal_respiratory_mucosa1.24945967
57MP0006082_CNS_inflammation1.24861799
58MP0010155_abnormal_intestine_physiology1.20027718
59MP0001845_abnormal_inflammatory_respons1.19662563
60MP0005379_endocrine/exocrine_gland_phen1.18338775
61MP0005410_abnormal_fertilization1.16638534
62MP0000703_abnormal_thymus_morphology1.15125824
63MP0005253_abnormal_eye_physiology1.14533188
64MP0001986_abnormal_taste_sensitivity1.13219623
65MP0003195_calcinosis1.12658146
66MP0000689_abnormal_spleen_morphology1.12519873
67MP0004142_abnormal_muscle_tone1.11695276
68MP0002419_abnormal_innate_immunity1.10015964
69MP0001485_abnormal_pinna_reflex1.09900823
70MP0009764_decreased_sensitivity_to1.09854420
71MP0002095_abnormal_skin_pigmentation1.05715750
72MP0006276_abnormal_autonomic_nervous1.05195868
73MP0002638_abnormal_pupillary_reflex1.04571096
74MP0002722_abnormal_immune_system1.02719381
75MP0001501_abnormal_sleep_pattern1.02222692
76MP0002429_abnormal_blood_cell0.99806400
77MP0004742_abnormal_vestibular_system0.98988160
78MP0003880_abnormal_central_pattern0.98893190
79MP0001765_abnormal_ion_homeostasis0.97660947
80MP0008995_early_reproductive_senescence0.97409683
81MP0002272_abnormal_nervous_system0.93807938
82MP0009745_abnormal_behavioral_response0.91843305
83MP0002693_abnormal_pancreas_physiology0.91701730
84MP0008469_abnormal_protein_level0.88318349
85MP0002160_abnormal_reproductive_system0.83682048
86MP0003252_abnormal_bile_duct0.82515354
87MP0002234_abnormal_pharynx_morphology0.81610703
88MP0001970_abnormal_pain_threshold0.77879948
89MP0005084_abnormal_gallbladder_morpholo0.75919789
90MP0003045_fibrosis0.75399697
91MP0005636_abnormal_mineral_homeostasis0.75380381
92MP0003786_premature_aging0.74328387
93MP0002733_abnormal_thermal_nociception0.74294396
94MP0005360_urolithiasis0.74036278
95MP0002653_abnormal_ependyma_morphology0.73531184
96MP0004947_skin_inflammation0.73358319
97MP0001533_abnormal_skeleton_physiology0.68918721
98MP0000230_abnormal_systemic_arterial0.67616836
99MP0008789_abnormal_olfactory_epithelium0.66543055
100MP0004381_abnormal_hair_follicle0.66373856

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.85235693
2T lymphocytopenia (HP:0005403)4.56961807
3Abnormality of T cell number (HP:0011839)4.48451851
4Aplastic anemia (HP:0001915)4.37071535
5Elevated erythrocyte sedimentation rate (HP:0003565)4.26180474
6Severe combined immunodeficiency (HP:0004430)4.22750561
7Congenital stationary night blindness (HP:0007642)4.01675531
8Hypoproteinemia (HP:0003075)3.84871724
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.84730733
10Increased IgM level (HP:0003496)3.74430638
11Abnormality of B cell number (HP:0010975)3.53636610
12Thyroiditis (HP:0100646)3.49576745
13Mitochondrial inheritance (HP:0001427)3.36504934
14Acute necrotizing encephalopathy (HP:0006965)3.30454386
15Abnormality of T cells (HP:0002843)3.24717267
16Abnormal rod and cone electroretinograms (HP:0008323)3.21389944
17Combined immunodeficiency (HP:0005387)3.19677723
18Autoimmune hemolytic anemia (HP:0001890)3.18308102
19Abnormal mitochondria in muscle tissue (HP:0008316)3.03925905
20Abnormality of eosinophils (HP:0001879)3.00681162
21B lymphocytopenia (HP:0010976)2.97348007
22Stomatitis (HP:0010280)2.92553585
23Attenuation of retinal blood vessels (HP:0007843)2.84254632
24Pancreatic cysts (HP:0001737)2.82297172
253-Methylglutaconic aciduria (HP:0003535)2.78033646
26Increased CSF lactate (HP:0002490)2.75430402
27Progressive macrocephaly (HP:0004481)2.72957047
28Increased intramyocellular lipid droplets (HP:0012240)2.72709293
29Acute encephalopathy (HP:0006846)2.65550113
30Abnormality of the prostate (HP:0008775)2.63040087
31Increased hepatocellular lipid droplets (HP:0006565)2.58774887
32Pancreatic fibrosis (HP:0100732)2.58617150
33Hepatocellular necrosis (HP:0001404)2.57847379
34Abolished electroretinogram (ERG) (HP:0000550)2.55719254
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.51636133
36Chronic diarrhea (HP:0002028)2.48799704
37Abnormality of cells of the erythroid lineage (HP:0012130)2.47282070
38Decreased central vision (HP:0007663)2.45207611
39True hermaphroditism (HP:0010459)2.43398551
40Renal Fanconi syndrome (HP:0001994)2.37984207
41Eosinophilia (HP:0001880)2.35412839
42Pancytopenia (HP:0001876)2.34392152
43Molar tooth sign on MRI (HP:0002419)2.30598990
44Abnormality of midbrain morphology (HP:0002418)2.30598990
45Optic disc pallor (HP:0000543)2.29113748
46Lipid accumulation in hepatocytes (HP:0006561)2.28871969
47Recurrent bronchitis (HP:0002837)2.23548815
48Increased muscle lipid content (HP:0009058)2.23140898
49Hepatic necrosis (HP:0002605)2.23127526
50Cerebral edema (HP:0002181)2.22378880
51Abnormal number of erythroid precursors (HP:0012131)2.20865766
52Leukocytosis (HP:0001974)2.19976925
53Reticulocytopenia (HP:0001896)2.18607767
54Abnormality of the renal cortex (HP:0011035)2.18447365
55Encephalitis (HP:0002383)2.18397701
56Hypoplasia of the thymus (HP:0000778)2.12466605
57Type II lissencephaly (HP:0007260)2.12062780
58Abnormal albumin level (HP:0012116)2.09379258
59Hypoalbuminemia (HP:0003073)2.09379258
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.08559139
61Panhypogammaglobulinemia (HP:0003139)2.07855536
62Absent thumb (HP:0009777)2.06989482
63Type 2 muscle fiber atrophy (HP:0003554)2.05952149
64Constricted visual fields (HP:0001133)2.02692777
65Bronchitis (HP:0012387)2.00023958
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98822652
67Agammaglobulinemia (HP:0004432)1.96287012
68Aplasia/Hypoplasia of the spleen (HP:0010451)1.94934168
69Asplenia (HP:0001746)1.93993387
70Pendular nystagmus (HP:0012043)1.93925772
71Renal cortical cysts (HP:0000803)1.92668327
72Hypergammaglobulinemia (HP:0010702)1.90826305
73Keratoconus (HP:0000563)1.90075849
74Increased corneal curvature (HP:0100692)1.90075849
75Abnormal respiratory motile cilium physiology (HP:0012261)1.89456474
76Abnormal drinking behavior (HP:0030082)1.89186626
77Polydipsia (HP:0001959)1.89186626
78Stenosis of the external auditory canal (HP:0000402)1.88974689
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88012734
80Chronic obstructive pulmonary disease (HP:0006510)1.87848736
81Obstructive lung disease (HP:0006536)1.87848736
82Methylmalonic acidemia (HP:0002912)1.87108829
83Severe visual impairment (HP:0001141)1.86017924
84Lymphopenia (HP:0001888)1.85174420
85Macrocytic anemia (HP:0001972)1.84943696
86Medial flaring of the eyebrow (HP:0010747)1.84139812
87Autoimmune thrombocytopenia (HP:0001973)1.82304173
88Increased serum lactate (HP:0002151)1.80417830
89Lactic acidosis (HP:0003128)1.79547219
90Abnormality of cells of the lymphoid lineage (HP:0012140)1.78349566
91Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77838706
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77838706
93Abnormality of T cell physiology (HP:0011840)1.77504437
94Amyotrophic lateral sclerosis (HP:0007354)1.76703049
95Meningitis (HP:0001287)1.76491399
96Nephronophthisis (HP:0000090)1.76173083
97Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76113866
98Sclerocornea (HP:0000647)1.75566049
99Polyuria (HP:0000103)1.74610508
100Ketosis (HP:0001946)1.73496891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.22304277
2TESK24.98496820
3KDR4.75054738
4BCKDK2.77842641
5MAP4K12.58276866
6TLK12.53599771
7ZAK2.42956304
8ADRBK22.39057059
9GRK12.28042848
10TAOK32.13659866
11ITK2.12758223
12MAP3K121.99009974
13GRK61.95743245
14CDK191.84994076
15MAP4K21.79361099
16FRK1.75469737
17MUSK1.73134317
18VRK21.71606039
19FES1.70970747
20LIMK11.63917118
21SYK1.50560949
22PINK11.49788617
23WNK41.44048482
24SCYL21.43700402
25TEC1.41262542
26NUAK11.41132313
27PASK1.39865956
28MAP3K111.35834904
29TESK11.33587447
30BTK1.33229203
31PRKCQ1.30091882
32IKBKB1.19455966
33VRK11.16844819
34TIE11.11198191
35CAMKK21.06453415
36TNK21.05980270
37LCK1.05735735
38MYLK1.05607589
39MAPKAPK31.00918364
40IKBKE0.97696758
41STK160.97615032
42GRK70.95646172
43PIK3CA0.91195828
44ZAP700.91102756
45LYN0.90879852
46INSRR0.90649899
47CSK0.89406699
48CAMKK10.88236127
49DAPK10.79070499
50KIT0.75779355
51CSF1R0.75763870
52NME10.73922696
53TBK10.67608273
54BMPR1B0.66300134
55MAP2K70.66267725
56PIM10.64705340
57MAPK130.62951948
58ADRBK10.62924005
59RPS6KA50.60831157
60JAK30.60471467
61OBSCN0.59148185
62OXSR10.58351412
63IGF1R0.55307115
64ROCK10.53965627
65MST40.53819119
66MAP2K20.53271842
67WNK30.51101400
68PIK3CG0.49400353
69TRPM70.48419854
70PRKCA0.47124992
71BMPR20.46835115
72DAPK30.45659182
73PRKACA0.43385444
74CAMK10.42911565
75FYN0.42874356
76DAPK20.41816857
77HCK0.39944245
78AURKA0.37158344
79MAP2K60.36467685
80PRKCG0.36187527
81ERBB30.36104545
82PRKCH0.35309231
83PRKCD0.35284104
84INSR0.34643538
85MAPK150.33805555
86DYRK20.33247100
87NTRK20.32988887
88STK390.32777375
89RPS6KA40.32388587
90MATK0.29877454
91PIM20.29449828
92CAMK2A0.26944242
93PAK10.26072450
94MARK30.25851795
95PHKG20.25692116
96PHKG10.25692116
97GRK50.25433407
98ABL10.24326765
99NLK0.23830371
100MAP3K40.22366144

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.24849697
2Oxidative phosphorylation_Homo sapiens_hsa001903.40090996
3Ribosome_Homo sapiens_hsa030103.31384676
4Proteasome_Homo sapiens_hsa030503.06037609
5Graft-versus-host disease_Homo sapiens_hsa053323.01533304
6Autoimmune thyroid disease_Homo sapiens_hsa053202.78310950
7Antigen processing and presentation_Homo sapiens_hsa046122.70885266
8Allograft rejection_Homo sapiens_hsa053302.70604987
9Parkinsons disease_Homo sapiens_hsa050122.70004661
10Type I diabetes mellitus_Homo sapiens_hsa049402.29682482
11Hematopoietic cell lineage_Homo sapiens_hsa046402.18294566
12Phototransduction_Homo sapiens_hsa047442.15802197
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.06317261
14Asthma_Homo sapiens_hsa053102.02551280
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.02492318
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98137299
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90463955
18T cell receptor signaling pathway_Homo sapiens_hsa046601.89230113
19Alzheimers disease_Homo sapiens_hsa050101.80662328
20Cardiac muscle contraction_Homo sapiens_hsa042601.79173788
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.78691102
22Linoleic acid metabolism_Homo sapiens_hsa005911.58592963
23Huntingtons disease_Homo sapiens_hsa050161.55467671
24Nitrogen metabolism_Homo sapiens_hsa009101.52491112
25RNA polymerase_Homo sapiens_hsa030201.50141617
26Rheumatoid arthritis_Homo sapiens_hsa053231.47729285
27Caffeine metabolism_Homo sapiens_hsa002321.35776344
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31720288
29Protein export_Homo sapiens_hsa030601.31121016
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28583515
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27107833
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.25880135
33Homologous recombination_Homo sapiens_hsa034401.19694228
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15953864
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.09276312
36Olfactory transduction_Homo sapiens_hsa047401.04880236
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03753581
38Viral myocarditis_Homo sapiens_hsa054160.95372281
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89282731
40Nicotine addiction_Homo sapiens_hsa050330.86701236
41Peroxisome_Homo sapiens_hsa041460.85032987
42Retinol metabolism_Homo sapiens_hsa008300.84957978
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84192558
44Malaria_Homo sapiens_hsa051440.81267796
45Measles_Homo sapiens_hsa051620.79830325
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.79501047
47Chemical carcinogenesis_Homo sapiens_hsa052040.79218775
48RNA degradation_Homo sapiens_hsa030180.76061330
49Tryptophan metabolism_Homo sapiens_hsa003800.73609971
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72526494
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69245296
52Arachidonic acid metabolism_Homo sapiens_hsa005900.69031500
53Taste transduction_Homo sapiens_hsa047420.68108608
54Fanconi anemia pathway_Homo sapiens_hsa034600.66243756
55Butanoate metabolism_Homo sapiens_hsa006500.65596115
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.64378495
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62028604
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61631403
59Ether lipid metabolism_Homo sapiens_hsa005650.61096985
60Pyrimidine metabolism_Homo sapiens_hsa002400.58892080
61Collecting duct acid secretion_Homo sapiens_hsa049660.58502798
62Systemic lupus erythematosus_Homo sapiens_hsa053220.58157549
63Morphine addiction_Homo sapiens_hsa050320.57639011
64Staphylococcus aureus infection_Homo sapiens_hsa051500.56958122
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55402296
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51022299
67Purine metabolism_Homo sapiens_hsa002300.49903622
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46658513
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.46319641
70Fat digestion and absorption_Homo sapiens_hsa049750.45248274
71Shigellosis_Homo sapiens_hsa051310.45114136
72One carbon pool by folate_Homo sapiens_hsa006700.45001478
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43868651
74Salmonella infection_Homo sapiens_hsa051320.43712582
75Basal transcription factors_Homo sapiens_hsa030220.41031999
76Nucleotide excision repair_Homo sapiens_hsa034200.39127075
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36220609
78Propanoate metabolism_Homo sapiens_hsa006400.35661381
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34313153
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.34163610
81Metabolic pathways_Homo sapiens_hsa011000.34103171
82Salivary secretion_Homo sapiens_hsa049700.33369606
83Herpes simplex infection_Homo sapiens_hsa051680.33273659
84Regulation of autophagy_Homo sapiens_hsa041400.32843716
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30595589
86GABAergic synapse_Homo sapiens_hsa047270.30177749
87Leishmaniasis_Homo sapiens_hsa051400.29835244
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26718101
89African trypanosomiasis_Homo sapiens_hsa051430.23796843
90Ovarian steroidogenesis_Homo sapiens_hsa049130.23361638
91Serotonergic synapse_Homo sapiens_hsa047260.23052094
92ABC transporters_Homo sapiens_hsa020100.22224740
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.20970006
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.20687092
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17685119
96Chemokine signaling pathway_Homo sapiens_hsa040620.17324187
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.16094098
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15371918
99Tyrosine metabolism_Homo sapiens_hsa003500.14657519
100Renin secretion_Homo sapiens_hsa049240.14473891

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