ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.54396498
2	ribosomal small subunit assembly (GO:0000028)	5.29842999
3	ATP synthesis coupled proton transport (GO:0015986)	4.66165777
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.66165777
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.40807836
6	viral transcription (GO:0019083)	4.40676719
7	maturation of SSU-rRNA (GO:0030490)	4.38920930
8	translational termination (GO:0006415)	4.19256317
9	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.17044203
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.86990434
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.82099545
12	cytidine metabolic process (GO:0046087)	3.78258086
13	cytidine catabolic process (GO:0006216)	3.78258086
14	cytidine deamination (GO:0009972)	3.78258086
15	cotranslational protein targeting to membrane (GO:0006613)	3.75597490
16	translational elongation (GO:0006414)	3.75354620
17	protein targeting to ER (GO:0045047)	3.73855237
18	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.57698191
19	protein localization to endoplasmic reticulum (GO:0070972)	3.54151390
20	protein neddylation (GO:0045116)	3.47807743
21	behavioral response to nicotine (GO:0035095)	3.46894088
22	electron transport chain (GO:0022900)	3.45776739
23	respiratory electron transport chain (GO:0022904)	3.45555798
24	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.39036750
25	mast cell activation (GO:0045576)	3.36820854
26	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.36690691
27	negative regulation of mast cell activation (GO:0033004)	3.25661615
28	viral life cycle (GO:0019058)	3.17709262
29	mannosylation (GO:0097502)	3.05240331
30	platelet dense granule organization (GO:0060155)	3.04602151
31	positive regulation of prostaglandin secretion (GO:0032308)	3.02750617
32	cellular protein complex disassembly (GO:0043624)	3.00983491
33	ribosomal large subunit biogenesis (GO:0042273)	2.98957078
34	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.98193429
35	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.93808766
36	chaperone-mediated protein transport (GO:0072321)	2.92621677
37	regulation of isotype switching to IgG isotypes (GO:0048302)	2.91467311
38	protein complex biogenesis (GO:0070271)	2.90977844
39	ribosomal small subunit biogenesis (GO:0042274)	2.89945509
40	negative T cell selection (GO:0043383)	2.88426727
41	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.83441343
42	S-adenosylmethionine metabolic process (GO:0046500)	2.80874773
43	hydrogen ion transmembrane transport (GO:1902600)	2.79247071
44	kynurenine metabolic process (GO:0070189)	2.79062361
45	proton transport (GO:0015992)	2.76290366
46	indole-containing compound catabolic process (GO:0042436)	2.76252562
47	indolalkylamine catabolic process (GO:0046218)	2.76252562
48	tryptophan catabolic process (GO:0006569)	2.76252562
49	positive thymic T cell selection (GO:0045059)	2.75818367
50	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.74975803
51	hydrogen transport (GO:0006818)	2.74310449
52	translational initiation (GO:0006413)	2.73596379
53	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.73339247
54	translation (GO:0006412)	2.72025432
55	mast cell degranulation (GO:0043303)	2.69534506
56	mast cell activation involved in immune response (GO:0002279)	2.69534506
57	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.69392843
58	regulation of immunoglobulin secretion (GO:0051023)	2.69212116
59	cellular response to ATP (GO:0071318)	2.69044803
60	NADH dehydrogenase complex assembly (GO:0010257)	2.66806884
61	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.66806884
62	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.66806884
63	response to pheromone (GO:0019236)	2.66770826
64	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.66738869
65	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.66738869
66	cellular response to interleukin-15 (GO:0071350)	2.66414955
67	water-soluble vitamin biosynthetic process (GO:0042364)	2.65639891
68	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.65532083
69	positive T cell selection (GO:0043368)	2.65022760
70	regulation of T cell mediated cytotoxicity (GO:0001914)	2.63392105
71	rRNA catabolic process (GO:0016075)	2.63334117
72	ATP biosynthetic process (GO:0006754)	2.61428807
73	GPI anchor metabolic process (GO:0006505)	2.60227085
74	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.60220804
75	piRNA metabolic process (GO:0034587)	2.57926307
76	positive regulation of calcium-mediated signaling (GO:0050850)	2.57637992
77	negative regulation of response to food (GO:0032096)	2.56074344
78	negative regulation of appetite (GO:0032099)	2.56074344
79	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.56038426
80	regulation of regulatory T cell differentiation (GO:0045589)	2.55194814
81	regulation of interleukin-8 secretion (GO:2000482)	2.54557002
82	detection of light stimulus involved in sensory perception (GO:0050962)	2.54235208
83	detection of light stimulus involved in visual perception (GO:0050908)	2.54235208
84	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.51628405
85	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.51007049
86	positive regulation of defense response to virus by host (GO:0002230)	2.50607574
87	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.50290882
88	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.49739966
89	regulation of B cell receptor signaling pathway (GO:0050855)	2.49011868
90	cellular ketone body metabolic process (GO:0046950)	2.48464838
91	indolalkylamine metabolic process (GO:0006586)	2.48087615
92	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.47702538
93	mitochondrial respiratory chain complex assembly (GO:0033108)	2.47527612
94	preassembly of GPI anchor in ER membrane (GO:0016254)	2.47416737
95	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.46857256
96	positive regulation of fatty acid transport (GO:2000193)	2.45648990
97	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.43501437
98	aldehyde catabolic process (GO:0046185)	2.43147488
99	GPI anchor biosynthetic process (GO:0006506)	2.42314831
100	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.41462319

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.77932599
2	VDR_22108803_ChIP-Seq_LS180_Human	3.60944284
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.27678099
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.22570978
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.02919717
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.70114279
7	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.66479482
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.57212740
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.51218350
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.47348712
11	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.46814349
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.38104027
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.35065666
14	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.26433029
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.23346153
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.99087867
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.97227064
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.91034209
19	IGF1R_20145208_ChIP-Seq_DFB_Human	1.88783034
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.75329291
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.70037713
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.68623200
23	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.65061320
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64207862
25	GATA3_26560356_Chip-Seq_TH2_Human	1.63802181
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.63582347
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.63142189
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.56073874
29	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.53929172
30	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.49666336
31	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48413668
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.48276165
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47829757
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.47169191
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.45875222
36	EWS_26573619_Chip-Seq_HEK293_Human	1.42420740
37	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.39489788
38	AR_20517297_ChIP-Seq_VCAP_Human	1.37978142
39	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.37637112
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.33418205
41	TAF2_19829295_ChIP-Seq_ESCs_Human	1.31310262
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30190741
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30190741
44	NCOR_22424771_ChIP-Seq_293T_Human	1.29153456
45	NANOG_20526341_ChIP-Seq_ESCs_Human	1.28844441
46	RUNX_20019798_ChIP-Seq_JUKART_Human	1.28030343
47	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.27177425
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27173092
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26406291
50	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26105528
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.26075563
52	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.23984376
53	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.22038741
54	MYB_26560356_Chip-Seq_TH2_Human	1.21823421
55	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.21734416
56	FUS_26573619_Chip-Seq_HEK293_Human	1.20658388
57	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.18814700
58	P300_19829295_ChIP-Seq_ESCs_Human	1.18389072
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.15435109
60	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.15168815
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14958687
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14958687
63	IRF1_19129219_ChIP-ChIP_H3396_Human	1.13936416
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12857585
65	GATA3_27048872_Chip-Seq_THYMUS_Human	1.12366263
66	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.12170464
67	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.07780551
68	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.07074516
69	ERG_20517297_ChIP-Seq_VCAP_Human	1.06796991
70	MYC_19829295_ChIP-Seq_ESCs_Human	1.06786936
71	CBP_20019798_ChIP-Seq_JUKART_Human	1.06431708
72	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.06431708
73	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.06001113
74	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.05178275
75	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.04692257
76	ERA_21632823_ChIP-Seq_H3396_Human	1.04260914
77	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03931144
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.03042339
79	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00510671
80	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.00388499
81	BCL6_27268052_Chip-Seq_Bcells_Human	0.98670165
82	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.98466050
83	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.98283625
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97676034
85	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96017570
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95443756
87	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.95425856
88	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.94852394
89	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.94275505
90	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.93416326
91	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.93230983
92	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.92946011
93	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.92405355
94	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.90644275
95	P53_21459846_ChIP-Seq_SAOS-2_Human	0.90154709
96	RNF2_27304074_Chip-Seq_NSC_Mouse	0.89944257
97	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.89431085
98	STAT1_20625510_ChIP-Seq_HELA_Human	0.89267020
99	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.89036389
100	OCT4_20526341_ChIP-Seq_ESCs_Human	0.88552297

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.53430920
2	MP0009379_abnormal_foot_pigmentation	3.50287379
3	MP0001835_abnormal_antigen_presentation	3.28572556
4	MP0006072_abnormal_retinal_apoptosis	2.56127602
5	MP0009785_altered_susceptibility_to	2.42464820
6	MP0004885_abnormal_endolymph	2.24980774
7	MP0002102_abnormal_ear_morphology	2.20125681
8	MP0008875_abnormal_xenobiotic_pharmacok	2.07723760
9	MP0005551_abnormal_eye_electrophysiolog	2.06243482
10	MP0001800_abnormal_humoral_immune	1.98836336
11	MP0005000_abnormal_immune_tolerance	1.98093272
12	MP0005646_abnormal_pituitary_gland	1.96757621
13	MP0005377_hearing/vestibular/ear_phenot	1.90635228
14	MP0003878_abnormal_ear_physiology	1.90635228
15	MP0001968_abnormal_touch/_nociception	1.87646481
16	MP0002148_abnormal_hypersensitivity_rea	1.86337134
17	MP0002876_abnormal_thyroid_physiology	1.86320268
18	MP0005645_abnormal_hypothalamus_physiol	1.78005723
19	MP0000685_abnormal_immune_system	1.77461679
20	MP0004142_abnormal_muscle_tone	1.73315395
21	MP0008877_abnormal_DNA_methylation	1.71970397
22	MP0004147_increased_porphyrin_level	1.70828740
23	MP0006292_abnormal_olfactory_placode	1.67289722
24	MP0002723_abnormal_immune_serum	1.66025796
25	MP0003646_muscle_fatigue	1.65549050
26	MP0001905_abnormal_dopamine_level	1.65117176
27	MP0008872_abnormal_physiological_respon	1.64799476
28	MP0001790_abnormal_immune_system	1.63343995
29	MP0005387_immune_system_phenotype	1.63343995
30	MP0004145_abnormal_muscle_electrophysio	1.62811867
31	MP0001873_stomach_inflammation	1.57426025
32	MP0002736_abnormal_nociception_after	1.56057197
33	MP0005253_abnormal_eye_physiology	1.50445315
34	MP0006276_abnormal_autonomic_nervous	1.48348774
35	MP0003880_abnormal_central_pattern	1.47615514
36	MP0003724_increased_susceptibility_to	1.47385368
37	MP0002420_abnormal_adaptive_immunity	1.46138857
38	MP0001986_abnormal_taste_sensitivity	1.45284831
39	MP0001819_abnormal_immune_cell	1.43934935
40	MP0003436_decreased_susceptibility_to	1.42403386
41	MP0002163_abnormal_gland_morphology	1.42298929
42	MP0003011_delayed_dark_adaptation	1.40835810
43	MP0002452_abnormal_antigen_presenting	1.39395429
44	MP0003866_abnormal_defecation	1.37056345
45	MP0003195_calcinosis	1.36702266
46	MP0005025_abnormal_response_to	1.35203048
47	MP0002166_altered_tumor_susceptibility	1.34606800
48	MP0009333_abnormal_splenocyte_physiolog	1.34479630
49	MP0003787_abnormal_imprinting	1.34164859
50	MP0009764_decreased_sensitivity_to	1.27792754
51	MP0002234_abnormal_pharynx_morphology	1.24035677
52	MP0002272_abnormal_nervous_system	1.22700153
53	MP0002405_respiratory_system_inflammati	1.16812422
54	MP0002006_tumorigenesis	1.15936249
55	MP0002837_dystrophic_cardiac_calcinosis	1.14889900
56	MP0002653_abnormal_ependyma_morphology	1.12301468
57	MP0001765_abnormal_ion_homeostasis	1.11536007
58	MP0005075_abnormal_melanosome_morpholog	1.10641368
59	MP0005389_reproductive_system_phenotype	1.10609490
60	MP0002095_abnormal_skin_pigmentation	1.09000786
61	MP0002138_abnormal_hepatobiliary_system	1.08153047
62	MP0003763_abnormal_thymus_physiology	1.01177648
63	MP0001919_abnormal_reproductive_system	1.00355674
64	MP0001845_abnormal_inflammatory_respons	1.00282534
65	MP0000716_abnormal_immune_system	0.99865341
66	MP0001501_abnormal_sleep_pattern	0.99058918
67	MP0009745_abnormal_behavioral_response	0.98669703
68	MP0010155_abnormal_intestine_physiology	0.97938326
69	MP0002160_abnormal_reproductive_system	0.97496515
70	MP0005636_abnormal_mineral_homeostasis	0.97250619
71	MP0008789_abnormal_olfactory_epithelium	0.94696664
72	MP0005410_abnormal_fertilization	0.94316922
73	MP0004742_abnormal_vestibular_system	0.94308409
74	MP0000427_abnormal_hair_cycle	0.94229982
75	MP0001970_abnormal_pain_threshold	0.92869232
76	MP0001984_abnormal_olfaction	0.90921356
77	MP0008995_early_reproductive_senescence	0.90010381
78	MP0005423_abnormal_somatic_nervous	0.89989663
79	MP0005379_endocrine/exocrine_gland_phen	0.89613224
80	MP0002398_abnormal_bone_marrow	0.89409113
81	MP0001440_abnormal_grooming_behavior	0.86489817
82	MP0002419_abnormal_innate_immunity	0.86099418
83	MP0000689_abnormal_spleen_morphology	0.84302821
84	MP0005085_abnormal_gallbladder_physiolo	0.84211000
85	MP0001486_abnormal_startle_reflex	0.84049876
86	MP0005195_abnormal_posterior_eye	0.82417610
87	MP0006036_abnormal_mitochondrial_physio	0.82116480
88	MP0003045_fibrosis	0.80712892
89	MP0008469_abnormal_protein_level	0.76687789
90	MP0006082_CNS_inflammation	0.76489378
91	MP0001963_abnormal_hearing_physiology	0.75626762
92	MP0002733_abnormal_thermal_nociception	0.75556176
93	MP0002638_abnormal_pupillary_reflex	0.75033369
94	MP0009046_muscle_twitch	0.74677427
95	MP0000026_abnormal_inner_ear	0.74338650
96	MP0001529_abnormal_vocalization	0.74280395
97	MP0001485_abnormal_pinna_reflex	0.73294651
98	MP0002277_abnormal_respiratory_mucosa	0.72848720
99	MP0002933_joint_inflammation	0.72788337
100	MP0003786_premature_aging	0.70819422

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.97514082
2	Mitochondrial inheritance (HP:0001427)	3.63994557
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.56626256
4	IgG deficiency (HP:0004315)	3.54903659
5	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.47794636
6	Pancreatic cysts (HP:0001737)	3.43905797
7	3-Methylglutaconic aciduria (HP:0003535)	3.39787783
8	Congenital stationary night blindness (HP:0007642)	3.37011915
9	Acute encephalopathy (HP:0006846)	3.34982319
10	Progressive macrocephaly (HP:0004481)	3.32103255
11	Pancreatic fibrosis (HP:0100732)	3.29735941
12	Renal Fanconi syndrome (HP:0001994)	3.22376938
13	Increased CSF lactate (HP:0002490)	3.17603031
14	Increased IgM level (HP:0003496)	3.10006583
15	Hypoproteinemia (HP:0003075)	3.05691538
16	Hepatocellular necrosis (HP:0001404)	3.02927339
17	True hermaphroditism (HP:0010459)	2.99328940
18	Aplastic anemia (HP:0001915)	2.97239786
19	Lipid accumulation in hepatocytes (HP:0006561)	2.96166030
20	Increased hepatocellular lipid droplets (HP:0006565)	2.95623321
21	Abnormality of cells of the erythroid lineage (HP:0012130)	2.95181207
22	Abolished electroretinogram (ERG) (HP:0000550)	2.91487514
23	Reticulocytopenia (HP:0001896)	2.91313304
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.90711730
25	Molar tooth sign on MRI (HP:0002419)	2.84088831
26	Abnormality of midbrain morphology (HP:0002418)	2.84088831
27	Elevated erythrocyte sedimentation rate (HP:0003565)	2.77491231
28	Attenuation of retinal blood vessels (HP:0007843)	2.76213402
29	Generalized aminoaciduria (HP:0002909)	2.74031826
30	Increased intramyocellular lipid droplets (HP:0012240)	2.70697785
31	Hepatic necrosis (HP:0002605)	2.69466144
32	Optic disc pallor (HP:0000543)	2.68864755
33	Cerebral edema (HP:0002181)	2.54804673
34	Stomatitis (HP:0010280)	2.50369351
35	Decreased central vision (HP:0007663)	2.49018634
36	Abnormal number of erythroid precursors (HP:0012131)	2.48537161
37	Abnormal drinking behavior (HP:0030082)	2.47943980
38	Polydipsia (HP:0001959)	2.47943980
39	Severe combined immunodeficiency (HP:0004430)	2.46326171
40	Abnormality of the renal cortex (HP:0011035)	2.46208803
41	Medial flaring of the eyebrow (HP:0010747)	2.43980203
42	Congenital, generalized hypertrichosis (HP:0004540)	2.40667180
43	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.39704347
44	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.39704347
45	Increased muscle lipid content (HP:0009058)	2.39146029
46	Abnormality of the prostate (HP:0008775)	2.35436107
47	Type II lissencephaly (HP:0007260)	2.35245242
48	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.34046169
49	Abnormality of T cell number (HP:0011839)	2.32837322
50	Nephronophthisis (HP:0000090)	2.30619025
51	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.29326614
52	Absent thumb (HP:0009777)	2.26903512
53	Type 2 muscle fiber atrophy (HP:0003554)	2.24970623
54	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.24411996
55	Renal cortical cysts (HP:0000803)	2.20522987
56	Asplenia (HP:0001746)	2.20348648
57	Thyroiditis (HP:0100646)	2.18691194
58	Methylmalonic acidemia (HP:0002912)	2.18585594
59	Exertional dyspnea (HP:0002875)	2.17740229
60	Abnormality of renal resorption (HP:0011038)	2.15702371
61	Lactic acidosis (HP:0003128)	2.15429643
62	Polyuria (HP:0000103)	2.13972244
63	Cystic liver disease (HP:0006706)	2.11256950
64	T lymphocytopenia (HP:0005403)	2.10836024
65	Pallor (HP:0000980)	2.10423227
66	Increased serum lactate (HP:0002151)	2.09839178
67	Macrocytic anemia (HP:0001972)	2.09458918
68	Sclerocornea (HP:0000647)	2.07370420
69	Pancytopenia (HP:0001876)	2.07317047
70	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.04496817
71	Abnormality of the renal medulla (HP:0100957)	2.04210064
72	Absent/shortened dynein arms (HP:0200106)	2.03958953
73	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.03958953
74	Abnormality of DNA repair (HP:0003254)	2.03939198
75	Pendular nystagmus (HP:0012043)	1.98644333
76	Abnormality of eosinophils (HP:0001879)	1.93169671
77	Failure to thrive in infancy (HP:0001531)	1.91993603
78	Stenosis of the external auditory canal (HP:0000402)	1.91327703
79	Abnormality of B cell number (HP:0010975)	1.90233149
80	Hyperglycinemia (HP:0002154)	1.89745703
81	Hypothermia (HP:0002045)	1.85392837
82	Abnormality of urine glucose concentration (HP:0011016)	1.85258503
83	Glycosuria (HP:0003076)	1.85258503
84	Muscle fiber atrophy (HP:0100295)	1.84832305
85	Lethargy (HP:0001254)	1.82987451
86	Abnormality of T cells (HP:0002843)	1.82176213
87	Tetany (HP:0001281)	1.80957890
88	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.80013601
89	Anencephaly (HP:0002323)	1.79843846
90	Methylmalonic aciduria (HP:0012120)	1.79768018
91	Keratoconus (HP:0000563)	1.78500830
92	Increased corneal curvature (HP:0100692)	1.78500830
93	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.78476258
94	Abnormality of alanine metabolism (HP:0010916)	1.78476258
95	Hyperalaninemia (HP:0003348)	1.78476258
96	Abnormal urine output (HP:0012590)	1.75108333
97	Abnormal respiratory motile cilium morphology (HP:0005938)	1.73320249
98	Abnormal respiratory epithelium morphology (HP:0012253)	1.73320249
99	Ketosis (HP:0001946)	1.72055579
100	Respiratory failure (HP:0002878)	1.69307754

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.24523008
2	BCKDK	3.29788123
3	MAP4K2	3.09563989
4	TLK1	2.96715435
5	KDR	2.77877965
6	CDK19	2.76147108
7	ZAK	2.53605635
8	TAOK3	2.47028803
9	STK16	2.43455124
10	PINK1	2.35017431
11	ADRBK2	2.29027841
12	BMPR2	2.16610862
13	MAP4K1	2.14260459
14	GRK1	2.07888437
15	MAP3K12	2.02929636
16	SCYL2	1.99028885
17	FRK	1.90198746
18	NUAK1	1.74241173
19	KIT	1.73375990
20	GRK6	1.65866246
21	NME1	1.62068809
22	WNK4	1.61097738
23	FLT3	1.56563906
24	ITK	1.51942608
25	CSF1R	1.44628474
26	CAMKK2	1.36167088
27	MUSK	1.32160755
28	FES	1.30792720
29	TESK2	1.26560805
30	VRK2	1.24950050
31	IKBKB	1.24880703
32	VRK1	1.16657896
33	ERBB3	1.15182888
34	TEC	1.14059335
35	BTK	1.10844786
36	SYK	1.10647738
37	TIE1	1.06122166
38	OXSR1	1.05536936
39	PRKCQ	1.02588774
40	IKBKE	0.99730343
41	MYLK	0.98499204
42	INSRR	0.95225307
43	LCK	0.93021770
44	CAMKK1	0.86774908
45	BMPR1B	0.84781279
46	LYN	0.84244626
47	PHKG1	0.83921933
48	PHKG2	0.83921933
49	PASK	0.82938685
50	MAP3K4	0.82223721
51	DYRK2	0.81503234
52	LIMK1	0.79696817
53	TNK2	0.78875236
54	ADRBK1	0.76628037
55	PIK3CG	0.75793977
56	RPS6KA5	0.75150786
57	MAP2K2	0.73228163
58	WNK3	0.71786850
59	MST4	0.71052569
60	MAP2K7	0.70836354
61	GRK7	0.68000870
62	DAPK3	0.67453808
63	MAPK15	0.62684707
64	OBSCN	0.61367660
65	IGF1R	0.61222099
66	MAPK13	0.59609826
67	ZAP70	0.58024658
68	CSNK1G3	0.58008298
69	STK39	0.56941923
70	MATK	0.55320352
71	MAP2K6	0.54025761
72	PIK3CA	0.53868928
73	MAPKAPK3	0.53297880
74	PAK3	0.52560299
75	MAP3K11	0.52152479
76	DAPK1	0.52050024
77	TRPM7	0.50968844
78	CSNK1G2	0.48550777
79	PRKACA	0.47637193
80	PRKCA	0.45940219
81	PRKCE	0.44715458
82	HCK	0.44380218
83	JAK3	0.39650035
84	PIM1	0.39512780
85	ILK	0.38949192
86	ABL1	0.38266939
87	RPS6KA6	0.37626752
88	CAMK1	0.37144954
89	CAMK2A	0.36680063
90	PRKCG	0.35132584
91	CSNK2A2	0.33789061
92	ROCK1	0.31245047
93	FYN	0.27754979
94	PRKCD	0.27659484
95	DAPK2	0.27530730
96	GRK5	0.27096749
97	CSNK1A1	0.26897278
98	RPS6KA4	0.26813084
99	TBK1	0.26719251
100	CSNK1G1	0.26637566

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.80682347
2	Asthma_Homo sapiens_hsa05310	3.47448834
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.46429570
4	Allograft rejection_Homo sapiens_hsa05330	3.37922889
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.25235044
6	Graft-versus-host disease_Homo sapiens_hsa05332	3.08053921
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.91511061
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.89279906
9	Parkinsons disease_Homo sapiens_hsa05012	2.73999915
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.67122257
11	Proteasome_Homo sapiens_hsa03050	2.63681674
12	Protein export_Homo sapiens_hsa03060	2.04910954
13	Phototransduction_Homo sapiens_hsa04744	1.94768801
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.93262783
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.86151231
16	Antigen processing and presentation_Homo sapiens_hsa04612	1.85377022
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.84337369
18	Rheumatoid arthritis_Homo sapiens_hsa05323	1.78166594
19	Alzheimers disease_Homo sapiens_hsa05010	1.77033549
20	RNA polymerase_Homo sapiens_hsa03020	1.68176029
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.64673693
22	Huntingtons disease_Homo sapiens_hsa05016	1.60619962
23	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.55117504
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.52694824
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.52367033
26	One carbon pool by folate_Homo sapiens_hsa00670	1.41286738
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.31476710
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.31273944
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.29904454
30	Caffeine metabolism_Homo sapiens_hsa00232	1.14544331
31	RNA degradation_Homo sapiens_hsa03018	1.12268886
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07783465
33	Homologous recombination_Homo sapiens_hsa03440	1.05715780
34	Viral myocarditis_Homo sapiens_hsa05416	1.03721835
35	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.03521691
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.01798430
37	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.99804664
38	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.99516835
39	Fanconi anemia pathway_Homo sapiens_hsa03460	0.99133238
40	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.97544885
41	Collecting duct acid secretion_Homo sapiens_hsa04966	0.95862008
42	Peroxisome_Homo sapiens_hsa04146	0.93469944
43	Olfactory transduction_Homo sapiens_hsa04740	0.91951926
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.90650610
45	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.85531870
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84761070
47	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.83653848
48	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.82298444
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.81305683
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.78530459
51	Propanoate metabolism_Homo sapiens_hsa00640	0.76685993
52	Leishmaniasis_Homo sapiens_hsa05140	0.76467228
53	Nicotine addiction_Homo sapiens_hsa05033	0.74651051
54	Butanoate metabolism_Homo sapiens_hsa00650	0.72940093
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.71252592
56	Retinol metabolism_Homo sapiens_hsa00830	0.70429424
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.68986272
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68959368
59	Basal transcription factors_Homo sapiens_hsa03022	0.65796666
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63820565
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63404488
62	Pyrimidine metabolism_Homo sapiens_hsa00240	0.60194050
63	Taste transduction_Homo sapiens_hsa04742	0.59445394
64	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.57847406
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56326818
66	Morphine addiction_Homo sapiens_hsa05032	0.56048754
67	Purine metabolism_Homo sapiens_hsa00230	0.56000995
68	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.55079665
69	Nucleotide excision repair_Homo sapiens_hsa03420	0.53156689
70	Malaria_Homo sapiens_hsa05144	0.51677193
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.51078877
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.50651177
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.50458164
74	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.47871005
75	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.45189217
76	Metabolic pathways_Homo sapiens_hsa01100	0.42811472
77	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.40955763
78	Salivary secretion_Homo sapiens_hsa04970	0.40402370
79	Measles_Homo sapiens_hsa05162	0.40022279
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.39873703
81	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.38925845
82	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.37246091
83	Regulation of autophagy_Homo sapiens_hsa04140	0.37144472
84	Herpes simplex infection_Homo sapiens_hsa05168	0.33564033
85	Sulfur metabolism_Homo sapiens_hsa00920	0.33557030
86	Mismatch repair_Homo sapiens_hsa03430	0.28939535
87	Base excision repair_Homo sapiens_hsa03410	0.28671776
88	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.28370964
89	Sulfur relay system_Homo sapiens_hsa04122	0.27623248
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.27277419
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.27062014
92	Serotonergic synapse_Homo sapiens_hsa04726	0.26847406
93	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.26480210
94	Circadian entrainment_Homo sapiens_hsa04713	0.25725538
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.24797384
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.24782775
97	GABAergic synapse_Homo sapiens_hsa04727	0.22180979
98	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.20255493
99	Tyrosine metabolism_Homo sapiens_hsa00350	0.16476751
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.16332269

RPL34P31

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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