RPL34P33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle tissue regeneration (GO:0043403)9.85575704
2regulation of skeletal muscle contraction (GO:0014819)9.23072261
3response to muscle activity (GO:0014850)8.91403331
4negative regulation of skeletal muscle tissue development (GO:0048642)8.32469396
5actin-mediated cell contraction (GO:0070252)8.20640552
6cellular response to dexamethasone stimulus (GO:0071549)6.79574262
7response to activity (GO:0014823)6.38798346
8response to dexamethasone (GO:0071548)6.28989943
9actin filament-based movement (GO:0030048)5.77143782
10striated muscle adaptation (GO:0014888)5.46591932
11negative regulation of organelle assembly (GO:1902116)4.73106530
12protein K6-linked ubiquitination (GO:0085020)4.67893585
13regulation of muscle hypertrophy (GO:0014743)4.46996111
14protein trimerization (GO:0070206)4.46512418
15muscle adaptation (GO:0043500)4.36814191
16negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.29881488
17skeletal muscle contraction (GO:0003009)4.27896128
18response to testosterone (GO:0033574)4.20117095
19negative regulation of striated muscle tissue development (GO:0045843)4.12973601
20myotube cell development (GO:0014904)4.12669265
21response to electrical stimulus (GO:0051602)4.10877344
22motile cilium assembly (GO:0044458)4.08396671
23negative regulation of fatty acid biosynthetic process (GO:0045717)4.05993161
24negative regulation of muscle tissue development (GO:1901862)4.05202597
25dosage compensation (GO:0007549)4.05023908
26regulation of DNA methylation (GO:0044030)4.03415730
27protein polyglutamylation (GO:0018095)4.01169039
28muscle organ development (GO:0007517)3.96648632
29muscle structure development (GO:0061061)3.88228518
30regulation of gene expression by genetic imprinting (GO:0006349)3.87105058
31negative regulation of muscle organ development (GO:0048635)3.86625197
32tissue regeneration (GO:0042246)3.73379202
33positive regulation of histone H3-K4 methylation (GO:0051571)3.67239842
34DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.66971450
35skeletal muscle fiber development (GO:0048741)3.58953523
36positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.57566272
37genetic imprinting (GO:0071514)3.52380304
38cellular response to glucocorticoid stimulus (GO:0071385)3.51289558
39response to inactivity (GO:0014854)3.42232329
40cellular response to ketone (GO:1901655)3.39385867
41response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.35331160
42viral transcription (GO:0019083)3.29027048
43DNA damage response, signal transduction resulting in transcription (GO:0042772)3.27950006
44cellular response to corticosteroid stimulus (GO:0071384)3.26654745
45heparin metabolic process (GO:0030202)3.25153310
46heparin biosynthetic process (GO:0030210)3.25153310
47muscle system process (GO:0003012)3.22433452
48regulation of relaxation of muscle (GO:1901077)3.19145772
49muscle contraction (GO:0006936)3.14721641
50translational termination (GO:0006415)3.09411922
51cell proliferation in forebrain (GO:0021846)3.08353883
52regulation of centriole replication (GO:0046599)3.07145494
53ribosomal small subunit assembly (GO:0000028)2.97351264
54translational elongation (GO:0006414)2.97193976
55sarcoplasmic reticulum calcium ion transport (GO:0070296)2.97064013
56behavioral response to nicotine (GO:0035095)2.92342725
57maturation of SSU-rRNA (GO:0030490)2.83191952
58regulation of histone H3-K9 methylation (GO:0051570)2.80235141
59negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.80086267
60calcium ion import (GO:0070509)2.74766809
61dendritic spine morphogenesis (GO:0060997)2.74367887
62secondary heart field specification (GO:0003139)2.72699129
63heart field specification (GO:0003128)2.72699129
64regulation of female gonad development (GO:2000194)2.68000234
65mitochondrial calcium ion homeostasis (GO:0051560)2.65604771
66ribosomal small subunit biogenesis (GO:0042274)2.63293059
67negative regulation of histone methylation (GO:0031061)2.60741357
68viral genome replication (GO:0019079)2.59880160
69positive regulation of sodium ion transmembrane transport (GO:1902307)2.59702077
70negative regulation of histone acetylation (GO:0035067)2.59544435
71pattern specification involved in kidney development (GO:0061004)2.58818727
72cellular ketone body metabolic process (GO:0046950)2.58367237
73positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.57185102
74muscle fiber development (GO:0048747)2.56870050
75striated muscle contraction (GO:0006941)2.56410777
76negative regulation of reactive oxygen species metabolic process (GO:2000378)2.55324071
77regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.50727207
78negative regulation of fatty acid metabolic process (GO:0045922)2.50476222
79middle ear morphogenesis (GO:0042474)2.48919585
80nephron epithelium morphogenesis (GO:0072088)2.46593241
81nephron tubule morphogenesis (GO:0072078)2.46593241
82myoblast migration (GO:0051451)2.46157640
83negative regulation of developmental growth (GO:0048640)2.44886442
84regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.44409910
85regulation of synapse structural plasticity (GO:0051823)2.43467274
86somite development (GO:0061053)2.39342119
87sarcomere organization (GO:0045214)2.37911083
88axoneme assembly (GO:0035082)2.34964704
89negative regulation of peptidyl-lysine acetylation (GO:2000757)2.34714006
90mesonephros development (GO:0001823)2.33462821
91SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.31915461
92protein targeting to ER (GO:0045047)2.31795828
93cartilage morphogenesis (GO:0060536)2.31455300
94response to gravity (GO:0009629)15.3344472
95skeletal muscle adaptation (GO:0043501)12.8615571
96striated muscle atrophy (GO:0014891)12.7068752
97muscle atrophy (GO:0014889)11.3137057
98negative regulation of muscle hypertrophy (GO:0014741)11.1967213
99actin-myosin filament sliding (GO:0033275)10.0591408
100muscle filament sliding (GO:0030049)10.0591408

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human7.71516578
2EZH2_22144423_ChIP-Seq_EOC_Human6.37390792
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.43938826
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.14853181
5TAF15_26573619_Chip-Seq_HEK293_Human3.90762538
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.44945294
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.37207480
8AR_21572438_ChIP-Seq_LNCaP_Human3.26598321
9FUS_26573619_Chip-Seq_HEK293_Human2.64094804
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.49547848
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.48841060
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.42771161
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.40255635
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26744286
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22795764
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05988168
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.00194787
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97974514
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90471246
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85454653
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.85422521
22PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72440681
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72223451
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70567468
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.67420276
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65965341
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65577610
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.64247023
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63527993
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61724139
31TP53_20018659_ChIP-ChIP_R1E_Mouse1.59186474
32TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.57533777
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57254736
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55069302
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53600613
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53600613
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50842069
38GBX2_23144817_ChIP-Seq_PC3_Human1.48886551
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47855889
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47191081
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45703845
42RXR_22108803_ChIP-Seq_LS180_Human1.44270990
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43311397
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42459160
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38643281
46TP53_22573176_ChIP-Seq_HFKS_Human1.37997002
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36642872
48ER_23166858_ChIP-Seq_MCF-7_Human1.36087736
49CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.35722572
50REST_21632747_ChIP-Seq_MESCs_Mouse1.33249539
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26052438
52ZNF274_21170338_ChIP-Seq_K562_Hela1.25201174
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25126858
54SMAD4_21799915_ChIP-Seq_A2780_Human1.18462885
55TDRD3_21172665_ChIP-Seq_MCF-7_Human1.13412593
56KDM2B_26808549_Chip-Seq_REH_Human1.12701709
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12122389
58KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05486746
59MYC_19829295_ChIP-Seq_ESCs_Human1.05211310
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03099385
61MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.02734832
62TAL1_26923725_Chip-Seq_HPCs_Mouse1.00033955
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97052461
64P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97004891
65MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96180202
66P300_19829295_ChIP-Seq_ESCs_Human0.96109103
67CEBPB_22108803_ChIP-Seq_LS180_Human0.94996596
68CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93803918
69STAT1_20625510_ChIP-Seq_HELA_Human0.93476782
70SOX9_26525672_Chip-Seq_HEART_Mouse0.92271423
71RING1B_27294783_Chip-Seq_ESCs_Mouse0.91817930
72STAT3_23295773_ChIP-Seq_U87_Human0.90688075
73RNF2_27304074_Chip-Seq_NSC_Mouse0.89511745
74POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89354127
75BCAT_22108803_ChIP-Seq_LS180_Human0.87519193
76TCF4_23295773_ChIP-Seq_U87_Human0.87060297
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85418488
78CBP_20019798_ChIP-Seq_JUKART_Human0.84453493
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84453493
80FLI1_21867929_ChIP-Seq_TH2_Mouse0.83698238
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83346120
82NCOR_22424771_ChIP-Seq_293T_Human0.80791017
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80162444
84NANOG_20526341_ChIP-Seq_ESCs_Human0.79985136
85TP63_19390658_ChIP-ChIP_HaCaT_Human0.78597003
86MYC_27129775_Chip-Seq_CORNEA_Mouse0.78502744
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.76749961
88ERA_21632823_ChIP-Seq_H3396_Human0.75698929
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.74398906
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.74263027
91P53_21459846_ChIP-Seq_SAOS-2_Human0.73980962
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73819180
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.73688799
94SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73630986
95NR3C1_23031785_ChIP-Seq_PC12_Mouse0.73016402
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.71993815
97SOX2_22085726_ChIP-Seq_NPCs_Mouse0.71301613
98DNAJC2_21179169_ChIP-ChIP_NT2_Human0.71125535
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.71103744
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.69860685

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio5.75171089
2MP0000747_muscle_weakness5.29411299
3MP0002089_abnormal_postnatal_growth/wei4.30495176
4MP0004036_abnormal_muscle_relaxation3.72981396
5MP0000749_muscle_degeneration3.49652831
6MP0003705_abnormal_hypodermis_morpholog3.48053089
7MP0002269_muscular_atrophy3.38005867
8MP0000759_abnormal_skeletal_muscle3.15587700
9MP0002108_abnormal_muscle_morphology2.77058130
10MP0003787_abnormal_imprinting2.71721311
11MP0003646_muscle_fatigue2.71467067
12MP0002638_abnormal_pupillary_reflex2.70778894
13MP0005083_abnormal_biliary_tract2.56711624
14MP0005620_abnormal_muscle_contractility2.53931845
15MP0004087_abnormal_muscle_fiber2.53175873
16MP0002106_abnormal_muscle_physiology2.52136720
17MP0003959_abnormal_lean_body2.26895352
18MP0004142_abnormal_muscle_tone2.08572105
19MP0005369_muscle_phenotype2.00372932
20MP0003123_paternal_imprinting1.81599361
21MP0001968_abnormal_touch/_nociception1.80692659
22MP0000566_synostosis1.80228878
23MP0000750_abnormal_muscle_regeneration1.79859994
24MP0000751_myopathy1.78354336
25MP0002736_abnormal_nociception_after1.68716739
26MP0004270_analgesia1.65945685
27MP0000733_abnormal_muscle_development1.58234174
28MP0006292_abnormal_olfactory_placode1.50534298
29MP0000778_abnormal_nervous_system1.43506101
30MP0003937_abnormal_limbs/digits/tail_de1.42778806
31MP0004130_abnormal_muscle_cell1.39335883
32MP0000372_irregular_coat_pigmentation1.39282047
33MP0004885_abnormal_endolymph1.38927412
34MP0000427_abnormal_hair_cycle1.37515505
35MP0009379_abnormal_foot_pigmentation1.37218349
36MP0000049_abnormal_middle_ear1.36417460
37MP0003121_genomic_imprinting1.29909575
38MP0010030_abnormal_orbit_morphology1.28744133
39MP0002102_abnormal_ear_morphology1.28214734
40MP0002095_abnormal_skin_pigmentation1.25162784
41MP0002896_abnormal_bone_mineralization1.20210012
42MP0003880_abnormal_central_pattern1.16296890
43MP0009250_abnormal_appendicular_skeleto1.13244605
44MP0002837_dystrophic_cardiac_calcinosis1.12232707
45MP0004043_abnormal_pH_regulation1.12095729
46MP0003786_premature_aging1.12067386
47MP0003122_maternal_imprinting1.07281719
48MP0003045_fibrosis1.06451925
49MP0008877_abnormal_DNA_methylation1.04105081
50MP0005167_abnormal_blood-brain_barrier1.04075790
51MP0005646_abnormal_pituitary_gland1.01960705
52MP0003938_abnormal_ear_development1.01795566
53MP0002277_abnormal_respiratory_mucosa0.97445843
54MP0002272_abnormal_nervous_system0.94865585
55MP0000631_abnormal_neuroendocrine_gland0.94301164
56MP0005257_abnormal_intraocular_pressure0.93853324
57MP0009745_abnormal_behavioral_response0.92078721
58MP0002067_abnormal_sensory_capabilities0.88009694
59MP0002733_abnormal_thermal_nociception0.87537046
60MP0001348_abnormal_lacrimal_gland0.84368556
61MP0008872_abnormal_physiological_respon0.83493267
62MP0005423_abnormal_somatic_nervous0.81410464
63MP0000467_abnormal_esophagus_morphology0.81357609
64MP0001502_abnormal_circadian_rhythm0.78560565
65MP0004742_abnormal_vestibular_system0.78376709
66MP0002184_abnormal_innervation0.75381502
67MP0002734_abnormal_mechanical_nocicepti0.74691861
68MP0001486_abnormal_startle_reflex0.72647947
69MP0004484_altered_response_of0.69960648
70MP0002109_abnormal_limb_morphology0.69444471
71MP0008789_abnormal_olfactory_epithelium0.68653822
72MP0004084_abnormal_cardiac_muscle0.68146828
73MP0002557_abnormal_social/conspecific_i0.68027444
74MP0005452_abnormal_adipose_tissue0.67482035
75MP0002114_abnormal_axial_skeleton0.67151298
76MP0001485_abnormal_pinna_reflex0.66685184
77MP0008770_decreased_survivor_rate0.65379259
78MP0004134_abnormal_chest_morphology0.65144701
79MP0003119_abnormal_digestive_system0.63555010
80MP0008875_abnormal_xenobiotic_pharmacok0.63121595
81MP0001970_abnormal_pain_threshold0.62532417
82MP0006072_abnormal_retinal_apoptosis0.62193651
83MP0003950_abnormal_plasma_membrane0.62119320
84MP0003755_abnormal_palate_morphology0.62108900
85MP0000955_abnormal_spinal_cord0.61611559
86MP0005645_abnormal_hypothalamus_physiol0.61243184
87MP0002115_abnormal_skeleton_extremities0.60768157
88MP0004147_increased_porphyrin_level0.60361167
89MP0001661_extended_life_span0.60142498
90MP0002653_abnormal_ependyma_morphology0.59005075
91MP0003936_abnormal_reproductive_system0.58783511
92MP0005551_abnormal_eye_electrophysiolog0.58734009
93MP0006276_abnormal_autonomic_nervous0.58722653
94MP0000537_abnormal_urethra_morphology0.58345154
95MP0002116_abnormal_craniofacial_bone0.58244403
96MP0000230_abnormal_systemic_arterial0.57462970
97MP0004215_abnormal_myocardial_fiber0.54194882
98MP0005248_abnormal_Harderian_gland0.53283073
99MP0001984_abnormal_olfaction0.53186969
100MP0003942_abnormal_urinary_system0.52536779

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)9.23509851
2Distal arthrogryposis (HP:0005684)7.60940407
3Exercise-induced myalgia (HP:0003738)6.75261032
4Round ear (HP:0100830)6.68324819
5Mask-like facies (HP:0000298)6.62480370
6Nemaline bodies (HP:0003798)6.51056301
7Absent phalangeal crease (HP:0006109)5.97383623
8Ulnar deviation of the wrist (HP:0003049)5.95603880
9Calcaneovalgus deformity (HP:0001848)5.82214456
10Deformed tarsal bones (HP:0008119)5.45457478
11Muscle fiber inclusion bodies (HP:0100299)5.28560625
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.16966981
13Abnormal finger flexion creases (HP:0006143)5.04684442
14Hyperkalemia (HP:0002153)4.89874318
15Periorbital edema (HP:0100539)4.60964731
16Type 1 muscle fiber predominance (HP:0003803)4.54348335
17Facial edema (HP:0000282)4.44588486
18Myopathic facies (HP:0002058)4.01002901
19Myotonia (HP:0002486)3.57161677
20Myoglobinuria (HP:0002913)3.29764435
21Abnormality of potassium homeostasis (HP:0011042)3.19464186
22Exercise-induced muscle cramps (HP:0003710)3.14339693
23Abnormality of the calcaneus (HP:0008364)2.97342566
24Decreased circulating renin level (HP:0003351)2.93197735
25Neoplasm of the heart (HP:0100544)2.88285561
26Hyperphosphatemia (HP:0002905)2.85255977
27Nonprogressive disorder (HP:0003680)2.84208289
28Oligomenorrhea (HP:0000876)2.80250648
29Increased connective tissue (HP:0009025)2.79491051
30Metatarsus adductus (HP:0001840)2.69597081
31Down-sloping shoulders (HP:0200021)2.69381341
32Difficulty running (HP:0009046)2.68631389
33Reticulocytopenia (HP:0001896)2.65023581
34Muscle stiffness (HP:0003552)2.52454592
35Malignant hyperthermia (HP:0002047)2.41499246
36Stenosis of the external auditory canal (HP:0000402)2.41319038
37Congenital stationary night blindness (HP:0007642)2.39913982
38Fibular aplasia (HP:0002990)2.39243691
39Rectal prolapse (HP:0002035)2.38835457
40Microglossia (HP:0000171)2.33597459
413-Methylglutaconic aciduria (HP:0003535)2.32967241
42Hypokalemia (HP:0002900)2.28540507
43Rhabdomyolysis (HP:0003201)2.17003848
44Abnormality of midbrain morphology (HP:0002418)2.05339370
45Molar tooth sign on MRI (HP:0002419)2.05339370
46Abnormality of chloride homeostasis (HP:0011422)2.01893342
47Reduced subcutaneous adipose tissue (HP:0003758)2.01190626
48Tarsal synostosis (HP:0008368)1.99697753
49Colon cancer (HP:0003003)1.98518222
50Mesomelia (HP:0003027)1.98364085
51Abnormality of the peritoneum (HP:0002585)1.94525096
52Pancreatic fibrosis (HP:0100732)1.91580277
53Polydipsia (HP:0001959)1.90939316
54Abnormal drinking behavior (HP:0030082)1.90939316
55Aplasia/Hypoplasia of the tongue (HP:0010295)1.90761470
56Abnormality of the parietal bone (HP:0002696)1.90716268
57Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.88257506
58Short 4th metacarpal (HP:0010044)1.88257506
59Supernumerary bones of the axial skeleton (HP:0009144)1.87979676
60Abnormal rod and cone electroretinograms (HP:0008323)1.86084052
61Nephronophthisis (HP:0000090)1.85709638
62Abnormality of the nasal septum (HP:0000419)1.83975388
63Synostosis involving bones of the lower limbs (HP:0009138)1.83550915
64Synostosis involving bones of the feet (HP:0009140)1.83550915
65Supernumerary ribs (HP:0005815)1.82894094
66Bell-shaped thorax (HP:0001591)1.77686483
67Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76810316
68Lip pit (HP:0100267)1.74830660
69Abnormality of the renal medulla (HP:0100957)1.74503489
70Abnormality of the columella (HP:0009929)1.74107942
71Abnormality of the 4th metacarpal (HP:0010012)1.73342933
72Paralysis (HP:0003470)1.72179706
73Menstrual irregularities (HP:0000858)1.72069550
74Broad-based gait (HP:0002136)1.72026916
75Hypoplastic iliac wings (HP:0002866)1.71431414
76Maternal diabetes (HP:0009800)1.70960518
77Asplenia (HP:0001746)1.70284758
782-3 toe syndactyly (HP:0004691)1.69881747
79Anencephaly (HP:0002323)1.69526966
80Muscle hypertrophy of the lower extremities (HP:0008968)1.68218077
81Aplasia/Hypoplasia of the spleen (HP:0010451)1.63431946
82Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62062708
83Increased variability in muscle fiber diameter (HP:0003557)1.62033566
84Symphalangism affecting the phalanges of the hand (HP:0009773)1.60755982
85Abnormality of incisor morphology (HP:0011063)1.56809221
86Generalized muscle weakness (HP:0003324)1.56535593
87Acute necrotizing encephalopathy (HP:0006965)1.56026369
88Decreased subcutaneous fat (HP:0001002)1.55827097
89Short phalanx of the thumb (HP:0009660)1.55261819
90Abnormality of cells of the erythroid lineage (HP:0012130)1.54470790
91Abnormality of the renal collecting system (HP:0004742)1.51244634
92Hypoplastic ischia (HP:0003175)1.50888763
93Intellectual disability, moderate (HP:0002342)1.48219014
94Bile duct proliferation (HP:0001408)1.48156559
95Abnormal biliary tract physiology (HP:0012439)1.48156559
96Hyperaldosteronism (HP:0000859)1.47397054
97Wrist flexion contracture (HP:0001239)1.47059444
98Pendular nystagmus (HP:0012043)1.46566348
99Ulnar deviation of finger (HP:0009465)1.46360995
100Pancreatic cysts (HP:0001737)1.45112503

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG24.78267842
2PHKG14.78267842
3TIE14.45715541
4OBSCN4.42602323
5WNK43.94905824
6PINK13.01515779
7TYRO32.84674377
8PIK3CA2.68580424
9CAMKK22.45365979
10CAMK1D2.44703183
11WNK12.30858277
12LIMK12.02735361
13NUAK12.00735331
14MAPK131.84780772
15CAMK1G1.74584112
16JAK31.73600950
17MAP4K21.67983814
18CASK1.60838125
19MAP3K111.53607796
20BCKDK1.50628587
21ADRBK21.42103841
22PIK3CG1.36055610
23MUSK1.30911828
24DYRK1B1.30275113
25CHEK21.28517937
26NME21.20161307
27STK391.19499042
28TLK11.18080707
29TXK1.17565015
30CAMKK11.14775880
31AURKA1.13738283
32DMPK1.06770025
33EPHB21.06740135
34CDK41.05958321
35CAMK11.05621383
36CAMK2G1.04787023
37IRAK11.01224642
38CSNK1G20.98180260
39DAPK20.97911660
40GRK10.88876151
41CAMK40.84583271
42DYRK20.83453927
43DDR20.77849848
44MARK30.76730470
45CSNK1G10.76212841
46CSNK1A1L0.76168444
47TEC0.70680487
48MAP2K20.70104930
49ZAK0.67657786
50OXSR10.65799899
51MAP3K40.65375248
52SGK10.64808197
53EPHA40.64521629
54TAOK30.62471224
55MAP2K70.62351053
56MAP3K120.60577878
57TNIK0.60282990
58CSNK1G30.58857359
59SGK4940.58850189
60SGK2230.58850189
61FRK0.57994501
62SGK30.57409115
63TAF10.57192553
64MAPK70.56504993
65PRKG10.51960742
66MAPK120.50648359
67RPS6KA50.48568707
68PRKACA0.47237889
69TESK10.47015768
70VRK20.46739423
71STK110.43594282
72NTRK20.41719996
73STK160.40413336
74PRKCQ0.40250085
75ILK0.39146044
76CCNB10.38764489
77PIM10.38716383
78RPS6KA30.37187372
79VRK10.36304823
80RPS6KA60.36180395
81SGK20.34810270
82TRPM70.32696517
83PRKAA20.32524114
84MINK10.31529086
85PRKCG0.30955830
86PRKACB0.28705757
87MAP3K70.27362096
88PRKCA0.27267780
89PRKCH0.26320196
90CDK190.26227967
91ITK0.26115137
92RPS6KC10.25183356
93RPS6KL10.25183356
94FGFR20.24676610
95ABL20.24501031
96DYRK30.23573949
97GRK70.22282289
98PRKD20.21776449
99PRKD30.20094313
100ADRBK10.19416527

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.46725463
2Tight junction_Homo sapiens_hsa045303.92331601
3Regulation of autophagy_Homo sapiens_hsa041402.97700701
4Cardiac muscle contraction_Homo sapiens_hsa042602.80105934
5Nitrogen metabolism_Homo sapiens_hsa009102.45195315
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40239298
7Oxytocin signaling pathway_Homo sapiens_hsa049212.33718654
8Oxidative phosphorylation_Homo sapiens_hsa001901.98005606
9Hedgehog signaling pathway_Homo sapiens_hsa043401.94067619
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.87060388
11Calcium signaling pathway_Homo sapiens_hsa040201.83159531
12Insulin secretion_Homo sapiens_hsa049111.76859307
13Circadian entrainment_Homo sapiens_hsa047131.70500933
14Alzheimers disease_Homo sapiens_hsa050101.66165485
15Renin secretion_Homo sapiens_hsa049241.62898406
16Gastric acid secretion_Homo sapiens_hsa049711.62580890
17Vascular smooth muscle contraction_Homo sapiens_hsa042701.58024706
18Morphine addiction_Homo sapiens_hsa050321.57456908
19Basal cell carcinoma_Homo sapiens_hsa052171.54915576
20Parkinsons disease_Homo sapiens_hsa050121.52657657
21cGMP-PKG signaling pathway_Homo sapiens_hsa040221.43865089
22Olfactory transduction_Homo sapiens_hsa047401.40088564
23Caffeine metabolism_Homo sapiens_hsa002321.39823747
24Wnt signaling pathway_Homo sapiens_hsa043101.39492693
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36378171
26Salivary secretion_Homo sapiens_hsa049701.35242942
27RNA degradation_Homo sapiens_hsa030181.33663729
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33201817
29Dilated cardiomyopathy_Homo sapiens_hsa054141.30382538
30Asthma_Homo sapiens_hsa053101.21221748
31Nicotine addiction_Homo sapiens_hsa050331.20681120
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19527872
33Glucagon signaling pathway_Homo sapiens_hsa049221.18189809
34Linoleic acid metabolism_Homo sapiens_hsa005911.17372868
35GABAergic synapse_Homo sapiens_hsa047271.17103490
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14260143
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11316346
38Huntingtons disease_Homo sapiens_hsa050161.08035383
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06603791
40Cholinergic synapse_Homo sapiens_hsa047251.06456554
41Arginine biosynthesis_Homo sapiens_hsa002201.05879875
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05598605
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05390664
44Dopaminergic synapse_Homo sapiens_hsa047281.04013233
45Long-term depression_Homo sapiens_hsa047301.00742188
46Phototransduction_Homo sapiens_hsa047440.98512386
47Long-term potentiation_Homo sapiens_hsa047200.96448165
48Proteasome_Homo sapiens_hsa030500.94992938
49Circadian rhythm_Homo sapiens_hsa047100.92350628
50Axon guidance_Homo sapiens_hsa043600.91784757
51Basal transcription factors_Homo sapiens_hsa030220.90589697
52Autoimmune thyroid disease_Homo sapiens_hsa053200.89306518
53Fanconi anemia pathway_Homo sapiens_hsa034600.83908874
54RNA polymerase_Homo sapiens_hsa030200.82921446
55Allograft rejection_Homo sapiens_hsa053300.82421420
56Serotonergic synapse_Homo sapiens_hsa047260.81265398
57Chemical carcinogenesis_Homo sapiens_hsa052040.79831019
58cAMP signaling pathway_Homo sapiens_hsa040240.77688900
59Glutamatergic synapse_Homo sapiens_hsa047240.75644015
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75565327
61T cell receptor signaling pathway_Homo sapiens_hsa046600.73868455
62Amphetamine addiction_Homo sapiens_hsa050310.73709453
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72738732
64Pancreatic secretion_Homo sapiens_hsa049720.72583396
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72570496
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71179083
67MAPK signaling pathway_Homo sapiens_hsa040100.64525874
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60721901
69Peroxisome_Homo sapiens_hsa041460.60483172
70GnRH signaling pathway_Homo sapiens_hsa049120.60271034
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60239774
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.60128289
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60008038
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58504223
75Taste transduction_Homo sapiens_hsa047420.57841765
76Ovarian steroidogenesis_Homo sapiens_hsa049130.57838988
77Adherens junction_Homo sapiens_hsa045200.55591598
78Platelet activation_Homo sapiens_hsa046110.55340285
79Melanogenesis_Homo sapiens_hsa049160.54718933
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54055424
81Ras signaling pathway_Homo sapiens_hsa040140.47073666
82Systemic lupus erythematosus_Homo sapiens_hsa053220.45084598
83Dorso-ventral axis formation_Homo sapiens_hsa043200.43060175
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42469494
85Sulfur relay system_Homo sapiens_hsa041220.41436483
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38774977
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37885567
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37769412
89Tryptophan metabolism_Homo sapiens_hsa003800.36610999
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36288569
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35535460
92Oocyte meiosis_Homo sapiens_hsa041140.35530395
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35501044
94Notch signaling pathway_Homo sapiens_hsa043300.34009584
95Arachidonic acid metabolism_Homo sapiens_hsa005900.33677430
96Melanoma_Homo sapiens_hsa052180.32410747
97Retinol metabolism_Homo sapiens_hsa008300.31972141
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30471307
99Fat digestion and absorption_Homo sapiens_hsa049750.28751173
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28413172

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