ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	6.34490826
2	ribosomal small subunit assembly (GO:0000028)	6.30755163
3	translational termination (GO:0006415)	6.10220483
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.23979232
5	ATP synthesis coupled proton transport (GO:0015986)	5.23979232
6	DNA deamination (GO:0045006)	5.22119761
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.20345568
8	ribosomal small subunit biogenesis (GO:0042274)	5.19585989
9	cotranslational protein targeting to membrane (GO:0006613)	5.13183348
10	protein targeting to ER (GO:0045047)	5.12164274
11	translational elongation (GO:0006414)	5.11264623
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.86692166
13	behavioral response to nicotine (GO:0035095)	4.82603240
14	protein localization to endoplasmic reticulum (GO:0070972)	4.82080776
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.76432203
16	maturation of SSU-rRNA (GO:0030490)	4.68860694
17	cellular protein complex disassembly (GO:0043624)	4.60040033
18	viral life cycle (GO:0019058)	4.48915363
19	protein neddylation (GO:0045116)	4.14670858
20	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.12656399
21	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.95828390
22	protein complex disassembly (GO:0043241)	3.82630629
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.79602507
24	water-soluble vitamin biosynthetic process (GO:0042364)	3.75406207
25	translational initiation (GO:0006413)	3.74642198
26	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.65714320
27	regulation of cilium movement (GO:0003352)	3.64022953
28	macromolecular complex disassembly (GO:0032984)	3.63721510
29	cytidine metabolic process (GO:0046087)	3.62013177
30	cytidine catabolic process (GO:0006216)	3.62013177
31	cytidine deamination (GO:0009972)	3.62013177
32	protein complex biogenesis (GO:0070271)	3.61256805
33	chaperone-mediated protein transport (GO:0072321)	3.51566825
34	respiratory electron transport chain (GO:0022904)	3.51197091
35	electron transport chain (GO:0022900)	3.50601193
36	kynurenine metabolic process (GO:0070189)	3.41747206
37	ribosomal large subunit biogenesis (GO:0042273)	3.40049501
38	protein targeting to membrane (GO:0006612)	3.34470295
39	GTP biosynthetic process (GO:0006183)	3.31596439
40	piRNA metabolic process (GO:0034587)	3.28888518
41	epithelial cilium movement (GO:0003351)	3.28157257
42	translation (GO:0006412)	3.24201541
43	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.17951193
44	positive regulation of respiratory burst (GO:0060267)	3.16743953
45	hydrogen ion transmembrane transport (GO:1902600)	3.14161580
46	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.13861085
47	ATP biosynthetic process (GO:0006754)	3.13642168
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.13032085
49	pyrimidine nucleobase catabolic process (GO:0006208)	3.12489371
50	cell proliferation in forebrain (GO:0021846)	3.12170055
51	mitochondrial respiratory chain complex assembly (GO:0033108)	3.10924064
52	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.09491886
53	NADH dehydrogenase complex assembly (GO:0010257)	3.09491886
54	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.09491886
55	tryptophan catabolic process (GO:0006569)	3.08660727
56	indole-containing compound catabolic process (GO:0042436)	3.08660727
57	indolalkylamine catabolic process (GO:0046218)	3.08660727
58	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.04856463
59	positive regulation of T cell apoptotic process (GO:0070234)	3.02996787
60	nonmotile primary cilium assembly (GO:0035058)	3.00944209
61	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.98486645
62	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.98486645
63	axonemal dynein complex assembly (GO:0070286)	2.97568692
64	proton transport (GO:0015992)	2.92092703
65	regulation of microtubule-based movement (GO:0060632)	2.90087657
66	axoneme assembly (GO:0035082)	2.89890175
67	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.89343333
68	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.88895648
69	hydrogen transport (GO:0006818)	2.87920821
70	mRNA catabolic process (GO:0006402)	2.87072706
71	positive regulation of prostaglandin secretion (GO:0032308)	2.83610045
72	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.82266415
73	metallo-sulfur cluster assembly (GO:0031163)	2.81163647
74	iron-sulfur cluster assembly (GO:0016226)	2.81163647
75	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.80982224
76	substrate-independent telencephalic tangential migration (GO:0021826)	2.80982224
77	cellular component biogenesis (GO:0044085)	2.79813743
78	nucleobase catabolic process (GO:0046113)	2.78192269
79	cilium movement (GO:0003341)	2.75851082
80	neuron fate determination (GO:0048664)	2.75243323
81	rRNA catabolic process (GO:0016075)	2.74778115
82	sequestering of actin monomers (GO:0042989)	2.74564480
83	negative regulation of T cell differentiation in thymus (GO:0033085)	2.72352701
84	DNA methylation involved in gamete generation (GO:0043046)	2.69202580
85	negative regulation of response to food (GO:0032096)	2.68903263
86	negative regulation of appetite (GO:0032099)	2.68903263
87	indolalkylamine metabolic process (GO:0006586)	2.67115660
88	protein localization to cilium (GO:0061512)	2.67000821
89	negative regulation of mast cell activation (GO:0033004)	2.65965650
90	ribonucleoprotein complex biogenesis (GO:0022613)	2.64280782
91	UTP biosynthetic process (GO:0006228)	2.63757810
92	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.62134214
93	resolution of meiotic recombination intermediates (GO:0000712)	2.60458547
94	RNA catabolic process (GO:0006401)	2.59942809
95	amine catabolic process (GO:0009310)	2.58755164
96	cellular biogenic amine catabolic process (GO:0042402)	2.58755164
97	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.58097833
98	base-excision repair, AP site formation (GO:0006285)	2.57802190
99	detection of light stimulus involved in sensory perception (GO:0050962)	2.57396564
100	detection of light stimulus involved in visual perception (GO:0050908)	2.57396564

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.48808217
2	VDR_22108803_ChIP-Seq_LS180_Human	2.61111263
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.47584356
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.45581458
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.45145351
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.42834252
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.41697248
8	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.22760780
9	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.20445931
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.04243793
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.02375708
12	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.90123906
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.88811031
14	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.86809449
15	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.84890126
16	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.83043337
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.76683644
18	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.70840811
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.68626953
20	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67876154
21	REST_21632747_ChIP-Seq_MESCs_Mouse	1.65770485
22	TP53_22573176_ChIP-Seq_HFKS_Human	1.65418526
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64259173
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.61442181
25	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.61270427
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.60769142
27	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.55887359
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.53911651
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.53911076
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.53171915
31	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.42633270
32	TAF2_19829295_ChIP-Seq_ESCs_Human	1.40428620
33	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.37911449
34	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36465949
35	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.35685561
36	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.35247869
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.34779416
38	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.34107625
39	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.29998121
40	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29902865
41	ERA_21632823_ChIP-Seq_H3396_Human	1.28451720
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28196603
43	NANOG_20526341_ChIP-Seq_ESCs_Human	1.27449358
44	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.26211905
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25929160
46	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.25533516
47	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.25273980
48	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.24996380
49	VDR_23849224_ChIP-Seq_CD4+_Human	1.24844927
50	EWS_26573619_Chip-Seq_HEK293_Human	1.24753072
51	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.22773886
52	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.22654716
53	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.22653363
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22507305
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22507305
56	MYC_19829295_ChIP-Seq_ESCs_Human	1.22195492
57	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.22082452
58	NCOR_22424771_ChIP-Seq_293T_Human	1.20283493
59	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.19969331
60	IGF1R_20145208_ChIP-Seq_DFB_Human	1.18893387
61	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.18288169
62	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.17535221
63	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.16872619
64	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.15050028
65	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.14269741
66	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.13773918
67	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.12665518
68	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.10433900
69	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.10433900
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08983397
71	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.08718751
72	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.08343165
73	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.07592707
74	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.07509226
75	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.07197390
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06510939
77	BCAT_22108803_ChIP-Seq_LS180_Human	1.06279053
78	FUS_26573619_Chip-Seq_HEK293_Human	1.05747203
79	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.05733558
80	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.05425610
81	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04409987
82	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.04179204
83	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.02661050
84	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02536141
85	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02536141
86	AR_20517297_ChIP-Seq_VCAP_Human	0.99472947
87	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98740370
88	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.98358188
89	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.97281507
90	CBP_20019798_ChIP-Seq_JUKART_Human	0.97281507
91	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.97199616
92	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.96623462
93	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.95585171
94	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95585171
95	P53_21459846_ChIP-Seq_SAOS-2_Human	0.94087786
96	ER_23166858_ChIP-Seq_MCF-7_Human	0.93836724
97	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.93246690
98	P300_19829295_ChIP-Seq_ESCs_Human	0.93129383
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92909599
100	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92340547

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.03784385
2	MP0006292_abnormal_olfactory_placode	3.35621985
3	MP0003787_abnormal_imprinting	3.26493158
4	MP0008789_abnormal_olfactory_epithelium	2.75217892
5	MP0008877_abnormal_DNA_methylation	2.65529293
6	MP0002163_abnormal_gland_morphology	2.55475015
7	MP0003646_muscle_fatigue	2.51237462
8	MP0005671_abnormal_response_to	2.32529037
9	MP0001984_abnormal_olfaction	2.12741429
10	MP0005499_abnormal_olfactory_system	2.12197321
11	MP0005394_taste/olfaction_phenotype	2.12197321
12	MP0008875_abnormal_xenobiotic_pharmacok	2.09883354
13	MP0004142_abnormal_muscle_tone	2.09640386
14	MP0006072_abnormal_retinal_apoptosis	2.00412901
15	MP0001968_abnormal_touch/_nociception	1.99039857
16	MP0005645_abnormal_hypothalamus_physiol	1.98450214
17	MP0004885_abnormal_endolymph	1.98229982
18	MP0005646_abnormal_pituitary_gland	1.97648505
19	MP0002653_abnormal_ependyma_morphology	1.89970415
20	MP0005551_abnormal_eye_electrophysiolog	1.88954138
21	MP0006276_abnormal_autonomic_nervous	1.77390853
22	MP0004145_abnormal_muscle_electrophysio	1.76519660
23	MP0004742_abnormal_vestibular_system	1.65571929
24	MP0002736_abnormal_nociception_after	1.62975502
25	MP0005379_endocrine/exocrine_gland_phen	1.62800773
26	MP0002272_abnormal_nervous_system	1.62271716
27	MP0003122_maternal_imprinting	1.61911842
28	MP0001905_abnormal_dopamine_level	1.59220226
29	MP0004147_increased_porphyrin_level	1.55559102
30	MP0001485_abnormal_pinna_reflex	1.53219505
31	MP0005389_reproductive_system_phenotype	1.52194683
32	MP0009745_abnormal_behavioral_response	1.51192367
33	MP0008872_abnormal_physiological_respon	1.50462040
34	MP0001986_abnormal_taste_sensitivity	1.47519898
35	MP0003121_genomic_imprinting	1.47116993
36	MP0003123_paternal_imprinting	1.46294099
37	MP0003011_delayed_dark_adaptation	1.46023156
38	MP0002160_abnormal_reproductive_system	1.45865419
39	MP0002876_abnormal_thyroid_physiology	1.45212112
40	MP0003880_abnormal_central_pattern	1.43336782
41	MP0002102_abnormal_ear_morphology	1.42732632
42	MP0005423_abnormal_somatic_nervous	1.31005525
43	MP0002138_abnormal_hepatobiliary_system	1.26780400
44	MP0002638_abnormal_pupillary_reflex	1.26703434
45	MP0002837_dystrophic_cardiac_calcinosis	1.24672226
46	MP0003878_abnormal_ear_physiology	1.23730164
47	MP0005377_hearing/vestibular/ear_phenot	1.23730164
48	MP0002733_abnormal_thermal_nociception	1.23366363
49	MP0002234_abnormal_pharynx_morphology	1.22731644
50	MP0001919_abnormal_reproductive_system	1.20010879
51	MP0009046_muscle_twitch	1.19543996
52	MP0001970_abnormal_pain_threshold	1.19329228
53	MP0001440_abnormal_grooming_behavior	1.17218698
54	MP0002938_white_spotting	1.13927617
55	MP0002557_abnormal_social/conspecific_i	1.13187742
56	MP0005253_abnormal_eye_physiology	1.12639416
57	MP0001188_hyperpigmentation	1.12556411
58	MP0005195_abnormal_posterior_eye	1.12314731
59	MP0003879_abnormal_hair_cell	1.11159003
60	MP0001501_abnormal_sleep_pattern	1.07685398
61	MP0000685_abnormal_immune_system	1.07597542
62	MP0002184_abnormal_innervation	1.03604533
63	MP0001293_anophthalmia	1.03543596
64	MP0000631_abnormal_neuroendocrine_gland	1.03503389
65	MP0002752_abnormal_somatic_nervous	1.01716309
66	MP0002572_abnormal_emotion/affect_behav	1.01372836
67	MP0001486_abnormal_startle_reflex	0.99164807
68	MP0001542_abnormal_bone_strength	0.99084899
69	MP0003635_abnormal_synaptic_transmissio	0.97831833
70	MP0001529_abnormal_vocalization	0.97158065
71	MP0000026_abnormal_inner_ear	0.96336029
72	MP0002735_abnormal_chemical_nociception	0.95986583
73	MP0000778_abnormal_nervous_system	0.94870164
74	MP0000049_abnormal_middle_ear	0.93862347
75	MP0003136_yellow_coat_color	0.93524494
76	MP0004133_heterotaxia	0.92749218
77	MP0003283_abnormal_digestive_organ	0.92657723
78	MP0001963_abnormal_hearing_physiology	0.91829567
79	MP0002063_abnormal_learning/memory/cond	0.91500015
80	MP0005360_urolithiasis	0.90989775
81	MP0009764_decreased_sensitivity_to	0.90786083
82	MP0005174_abnormal_tail_pigmentation	0.90551761
83	MP0002822_catalepsy	0.89747593
84	MP0000566_synostosis	0.89697095
85	MP0002064_seizures	0.89567247
86	MP0000955_abnormal_spinal_cord	0.89079243
87	MP0000427_abnormal_hair_cycle	0.88745124
88	MP0002095_abnormal_skin_pigmentation	0.88397456
89	MP0002734_abnormal_mechanical_nocicepti	0.88392508
90	MP0005410_abnormal_fertilization	0.87598102
91	MP0005084_abnormal_gallbladder_morpholo	0.87434812
92	MP0001502_abnormal_circadian_rhythm	0.83018872
93	MP0003938_abnormal_ear_development	0.82344935
94	MP0002067_abnormal_sensory_capabilities	0.82010595
95	MP0002210_abnormal_sex_determination	0.73866726
96	MP0003195_calcinosis	0.71384169
97	MP0002233_abnormal_nose_morphology	0.70854390
98	MP0002909_abnormal_adrenal_gland	0.70563901
99	MP0002277_abnormal_respiratory_mucosa	0.70321458
100	MP0002882_abnormal_neuron_morphology	0.68597272

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.21292941
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.09782701
3	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.84788491
4	Acute necrotizing encephalopathy (HP:0006965)	3.80653323
5	Congenital stationary night blindness (HP:0007642)	3.64440316
6	Abnormality of midbrain morphology (HP:0002418)	3.63325594
7	Molar tooth sign on MRI (HP:0002419)	3.63325594
8	Pancreatic fibrosis (HP:0100732)	3.60934967
9	Mitochondrial inheritance (HP:0001427)	3.58805212
10	Pancreatic cysts (HP:0001737)	3.58245320
11	Type II lissencephaly (HP:0007260)	3.43490668
12	Abnormal mitochondria in muscle tissue (HP:0008316)	3.43276999
13	Nephronophthisis (HP:0000090)	3.42687100
14	Abnormal rod and cone electroretinograms (HP:0008323)	3.32354306
15	Acute encephalopathy (HP:0006846)	3.31934180
16	Progressive macrocephaly (HP:0004481)	3.23171944
17	Increased CSF lactate (HP:0002490)	3.21202964
18	Increased hepatocellular lipid droplets (HP:0006565)	3.18009182
19	Pendular nystagmus (HP:0012043)	3.14831327
20	Abnormal number of erythroid precursors (HP:0012131)	3.07742285
21	Medial flaring of the eyebrow (HP:0010747)	3.03832558
22	True hermaphroditism (HP:0010459)	2.99396674
23	Macrocytic anemia (HP:0001972)	2.99358782
24	Lipid accumulation in hepatocytes (HP:0006561)	2.91759537
25	Renal Fanconi syndrome (HP:0001994)	2.82715032
26	Hepatocellular necrosis (HP:0001404)	2.80523773
27	3-Methylglutaconic aciduria (HP:0003535)	2.76957755
28	Abnormality of the renal medulla (HP:0100957)	2.72221456
29	Abnormal ciliary motility (HP:0012262)	2.70981363
30	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.68269851
31	Absent/shortened dynein arms (HP:0200106)	2.68269851
32	Increased intramyocellular lipid droplets (HP:0012240)	2.67792313
33	Decreased central vision (HP:0007663)	2.67440020
34	Hyperglycinemia (HP:0002154)	2.66516301
35	Abolished electroretinogram (ERG) (HP:0000550)	2.63429919
36	Optic disc pallor (HP:0000543)	2.63318543
37	Sclerocornea (HP:0000647)	2.60612229
38	Attenuation of retinal blood vessels (HP:0007843)	2.52718835
39	Keratoconus (HP:0000563)	2.50723267
40	Increased corneal curvature (HP:0100692)	2.50723267
41	IgG deficiency (HP:0004315)	2.49448610
42	Hepatic necrosis (HP:0002605)	2.49323151
43	Abnormal respiratory motile cilium morphology (HP:0005938)	2.46633206
44	Abnormal respiratory epithelium morphology (HP:0012253)	2.46633206
45	Myokymia (HP:0002411)	2.46405514
46	Pallor (HP:0000980)	2.45483927
47	Stenosis of the external auditory canal (HP:0000402)	2.44470099
48	Abnormal respiratory motile cilium physiology (HP:0012261)	2.44428490
49	Cerebellar dysplasia (HP:0007033)	2.43179397
50	Gait imbalance (HP:0002141)	2.42278395
51	Agitation (HP:0000713)	2.41785735
52	Colon cancer (HP:0003003)	2.41618279
53	Absent thumb (HP:0009777)	2.40636598
54	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.40305449
55	Cerebral edema (HP:0002181)	2.35748498
56	Increased IgM level (HP:0003496)	2.34855735
57	Abnormality of the renal cortex (HP:0011035)	2.33427040
58	Congenital primary aphakia (HP:0007707)	2.29725880
59	Hypoplasia of the uterus (HP:0000013)	2.26074123
60	Stomatitis (HP:0010280)	2.23886617
61	Aplasia/hypoplasia of the uterus (HP:0008684)	2.21208289
62	Increased muscle lipid content (HP:0009058)	2.20880587
63	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.20030383
64	Hyperthyroidism (HP:0000836)	2.19502186
65	Cystic liver disease (HP:0006706)	2.18363981
66	Bony spicule pigmentary retinopathy (HP:0007737)	2.15811001
67	Asplenia (HP:0001746)	2.15398898
68	Nephrogenic diabetes insipidus (HP:0009806)	2.15295607
69	Polydipsia (HP:0001959)	2.14896880
70	Abnormal drinking behavior (HP:0030082)	2.14896880
71	Septo-optic dysplasia (HP:0100842)	2.13150085
72	Tubular atrophy (HP:0000092)	2.12642185
73	Lissencephaly (HP:0001339)	2.12375173
74	Anencephaly (HP:0002323)	2.09841721
75	Elevated erythrocyte sedimentation rate (HP:0003565)	2.05997674
76	Male pseudohermaphroditism (HP:0000037)	2.05527974
77	Postaxial foot polydactyly (HP:0001830)	2.04812942
78	Abnormality of renal resorption (HP:0011038)	2.02488364
79	Increased serum lactate (HP:0002151)	2.01890726
80	Retinal dysplasia (HP:0007973)	2.01712927
81	Rib fusion (HP:0000902)	1.99656362
82	Supernumerary spleens (HP:0009799)	1.99411481
83	Abnormality of the labia minora (HP:0012880)	1.98797890
84	Pachygyria (HP:0001302)	1.98349967
85	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.93066485
86	Exertional dyspnea (HP:0002875)	1.92880854
87	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.87295514
88	Abnormality of urine glucose concentration (HP:0011016)	1.87224225
89	Glycosuria (HP:0003076)	1.87224225
90	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.85752155
91	Abnormality of alanine metabolism (HP:0010916)	1.85752155
92	Hyperalaninemia (HP:0003348)	1.85752155
93	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.81999061
94	Chronic hepatic failure (HP:0100626)	1.81200117
95	Neoplasm of the adrenal cortex (HP:0100641)	1.81050344
96	Concave nail (HP:0001598)	1.80800919
97	Lactic acidosis (HP:0003128)	1.76437058
98	Congenital hepatic fibrosis (HP:0002612)	1.75684476
99	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.75632583
100	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.75632583

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.36587949
2	WNK4	3.26213920
3	GRK1	3.22778127
4	ZAK	3.21064569
5	TAOK3	2.62863768
6	ADRBK2	2.58341641
7	TLK1	2.51041812
8	CDK19	2.40691712
9	DYRK2	2.39955999
10	TXK	2.38287531
11	BCKDK	2.37895526
12	VRK2	2.16770347
13	PINK1	1.93506475
14	TIE1	1.80463530
15	TESK2	1.73371858
16	NUAK1	1.68639172
17	STK39	1.66567309
18	MAP4K1	1.65353500
19	MAP4K2	1.55102088
20	WNK3	1.48789705
21	CSNK1G3	1.46605366
22	OXSR1	1.36323878
23	CSNK1G2	1.35324940
24	PIK3CA	1.33275632
25	LIMK1	1.30766029
26	MAP2K7	1.23587936
27	PHKG2	1.20639203
28	PHKG1	1.20639203
29	PRKCQ	1.18733637
30	KDR	1.18165370
31	BMPR1B	1.17259189
32	VRK1	1.16876426
33	TAF1	1.16661181
34	PRKCG	1.16201297
35	CSNK1A1L	1.13824359
36	ITK	1.13001456
37	TNIK	1.11465702
38	MAP3K11	1.10367216
39	CSNK1G1	1.09797985
40	PRKD3	1.07333302
41	SIK2	1.06667046
42	MAP3K4	1.05304569
43	KIT	1.02304234
44	GRK6	0.96419456
45	ADRBK1	0.94399973
46	NTRK2	0.92438465
47	CAMKK1	0.89175039
48	TEC	0.86042158
49	PASK	0.83231578
50	STK16	0.82240277
51	INSRR	0.81704544
52	MAPK13	0.79388699
53	DAPK2	0.77181458
54	BTK	0.76270993
55	IKBKB	0.75275479
56	GRK7	0.75040073
57	CAMKK2	0.72868996
58	MAP2K2	0.72536996
59	PAK3	0.71511562
60	MAPKAPK3	0.67654518
61	RPS6KA6	0.66888771
62	PRKACA	0.65825928
63	PRKCH	0.64887580
64	SYK	0.63534057
65	AURKA	0.62861138
66	MARK3	0.61457472
67	LRRK2	0.61388917
68	EPHA4	0.58964863
69	MAP3K12	0.58570779
70	OBSCN	0.58439263
71	CAMK1	0.56103676
72	MAPK15	0.56029754
73	TYRO3	0.55688292
74	CASK	0.52859126
75	DAPK3	0.52808547
76	EPHB2	0.52615475
77	DAPK1	0.51151933
78	STK11	0.50565402
79	PRKCI	0.49787742
80	GRK5	0.48417139
81	PRKCA	0.47794225
82	CSNK2A2	0.47721624
83	DYRK1B	0.46962774
84	PRKCD	0.46887884
85	RPS6KA5	0.46378249
86	MUSK	0.46371955
87	RPS6KA2	0.45427006
88	CSNK1A1	0.44471480
89	RPS6KC1	0.44123501
90	RPS6KL1	0.44123501
91	MARK1	0.43157875
92	SGK223	0.43134183
93	SGK494	0.43134183
94	CAMK2A	0.40799966
95	LCK	0.40416929
96	PRKCZ	0.37527212
97	CSNK1E	0.37238550
98	NEK2	0.37232454
99	MINK1	0.36778242
100	PLK1	0.36639491

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.27583601
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.11550367
3	Parkinsons disease_Homo sapiens_hsa05012	3.31580198
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.65403720
5	Phototransduction_Homo sapiens_hsa04744	2.53477742
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.42071770
7	Alzheimers disease_Homo sapiens_hsa05010	2.38639612
8	Huntingtons disease_Homo sapiens_hsa05016	2.16366313
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.16322689
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.14771378
11	Primary immunodeficiency_Homo sapiens_hsa05340	2.14252272
12	Caffeine metabolism_Homo sapiens_hsa00232	2.04896104
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.93645180
14	Protein export_Homo sapiens_hsa03060	1.92805283
15	Sulfur relay system_Homo sapiens_hsa04122	1.90712079
16	RNA polymerase_Homo sapiens_hsa03020	1.89799646
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.73967030
18	Asthma_Homo sapiens_hsa05310	1.57407320
19	Proteasome_Homo sapiens_hsa03050	1.54023591
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.47801721
21	Nicotine addiction_Homo sapiens_hsa05033	1.46316939
22	Allograft rejection_Homo sapiens_hsa05330	1.36599582
23	Homologous recombination_Homo sapiens_hsa03440	1.33801006
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31578443
25	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.30544912
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.29578325
27	Type I diabetes mellitus_Homo sapiens_hsa04940	1.28746388
28	RNA degradation_Homo sapiens_hsa03018	1.26466754
29	Butanoate metabolism_Homo sapiens_hsa00650	1.26460409
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.25128582
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.25117215
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.25085022
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.22772143
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.15656961
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.15091832
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.10111636
37	Graft-versus-host disease_Homo sapiens_hsa05332	1.08905820
38	Olfactory transduction_Homo sapiens_hsa04740	1.06468773
39	Peroxisome_Homo sapiens_hsa04146	1.04812628
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.03785622
41	Fat digestion and absorption_Homo sapiens_hsa04975	0.98392140
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.97750076
43	Propanoate metabolism_Homo sapiens_hsa00640	0.96379236
44	Morphine addiction_Homo sapiens_hsa05032	0.93530470
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91652008
46	Retinol metabolism_Homo sapiens_hsa00830	0.90656940
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.89077151
48	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.86002685
49	Insulin secretion_Homo sapiens_hsa04911	0.82343215
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78936823
51	Fanconi anemia pathway_Homo sapiens_hsa03460	0.77460340
52	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.76387112
53	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76037388
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.74173023
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.73705464
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71516312
57	One carbon pool by folate_Homo sapiens_hsa00670	0.71068811
58	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.68551329
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.68006760
60	GABAergic synapse_Homo sapiens_hsa04727	0.67845838
61	Rheumatoid arthritis_Homo sapiens_hsa05323	0.66445510
62	Purine metabolism_Homo sapiens_hsa00230	0.66422643
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66124783
64	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.65569907
65	Taste transduction_Homo sapiens_hsa04742	0.65369559
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.65061558
67	Basal transcription factors_Homo sapiens_hsa03022	0.64570068
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63875372
69	Antigen processing and presentation_Homo sapiens_hsa04612	0.63192511
70	Metabolic pathways_Homo sapiens_hsa01100	0.60771695
71	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.59989271
72	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.59180152
73	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.58963753
74	Regulation of autophagy_Homo sapiens_hsa04140	0.58840971
75	Sulfur metabolism_Homo sapiens_hsa00920	0.58153690
76	Circadian entrainment_Homo sapiens_hsa04713	0.57592280
77	Glutamatergic synapse_Homo sapiens_hsa04724	0.51763864
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51579685
79	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.51515740
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.51324290
81	Serotonergic synapse_Homo sapiens_hsa04726	0.50983064
82	Steroid biosynthesis_Homo sapiens_hsa00100	0.49190365
83	Folate biosynthesis_Homo sapiens_hsa00790	0.47541238
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46246493
85	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.43068198
86	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42056939
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40854487
88	Salivary secretion_Homo sapiens_hsa04970	0.39500565
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.39294986
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39034879
91	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.38757338
92	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.36102066
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.33526977
94	Nucleotide excision repair_Homo sapiens_hsa03420	0.33350863
95	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.31091562
96	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.30597199
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28019719
98	ABC transporters_Homo sapiens_hsa02010	0.27760509
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.25670153
100	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.24790416

RPL34P34

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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