ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.12538739
2	proteasome assembly (GO:0043248)	4.00405578
3	water-soluble vitamin biosynthetic process (GO:0042364)	3.95531174
4	response to pheromone (GO:0019236)	3.83877372
5	protein complex biogenesis (GO:0070271)	3.67901454
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.67320005
7	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.67109915
8	NADH dehydrogenase complex assembly (GO:0010257)	3.67109915
9	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.67109915
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.65264669
11	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.59913165
12	pyrimidine nucleobase catabolic process (GO:0006208)	3.55359488
13	respiratory chain complex IV assembly (GO:0008535)	3.53559224
14	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.48452140
15	protein localization to cilium (GO:0061512)	3.47074414
16	platelet dense granule organization (GO:0060155)	3.42112816
17	behavioral response to nicotine (GO:0035095)	3.41207781
18	replication fork processing (GO:0031297)	3.39741994
19	mitochondrial respiratory chain complex assembly (GO:0033108)	3.38229577
20	somite development (GO:0061053)	3.34499889
21	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.29435524
22	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.27876914
23	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.27388569
24	limb bud formation (GO:0060174)	3.25619360
25	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.21638012
26	chaperone-mediated protein transport (GO:0072321)	3.16588696
27	regulation of mitotic spindle checkpoint (GO:1903504)	3.15604279
28	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.15604279
29	regulation of transmission of nerve impulse (GO:0051969)	3.14611560
30	rRNA catabolic process (GO:0016075)	3.12252087
31	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.04883686
32	ATP synthesis coupled proton transport (GO:0015986)	3.04883686
33	peptidyl-histidine modification (GO:0018202)	3.03497862
34	cytochrome complex assembly (GO:0017004)	3.02546046
35	GPI anchor metabolic process (GO:0006505)	3.01852979
36	cornea development in camera-type eye (GO:0061303)	3.01841368
37	DNA double-strand break processing (GO:0000729)	2.96635064
38	nucleobase catabolic process (GO:0046113)	2.95760589
39	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.93209699
40	tryptophan catabolic process (GO:0006569)	2.92677354
41	indole-containing compound catabolic process (GO:0042436)	2.92677354
42	indolalkylamine catabolic process (GO:0046218)	2.92677354
43	inositol phosphate catabolic process (GO:0071545)	2.92024282
44	protein neddylation (GO:0045116)	2.91999796
45	resolution of meiotic recombination intermediates (GO:0000712)	2.89558315
46	regulation of cilium movement (GO:0003352)	2.89235824
47	aldehyde catabolic process (GO:0046185)	2.87727605
48	protein-cofactor linkage (GO:0018065)	2.87016348
49	intraciliary transport (GO:0042073)	2.83495793
50	cilium morphogenesis (GO:0060271)	2.81303687
51	rRNA modification (GO:0000154)	2.80793490
52	photoreceptor cell maintenance (GO:0045494)	2.76291303
53	ncRNA catabolic process (GO:0034661)	2.75074015
54	prenylation (GO:0097354)	2.74931624
55	protein prenylation (GO:0018342)	2.74931624
56	piRNA metabolic process (GO:0034587)	2.74787150
57	kynurenine metabolic process (GO:0070189)	2.71755909
58	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.71358912
59	xenobiotic catabolic process (GO:0042178)	2.70133231
60	negative regulation of telomere maintenance (GO:0032205)	2.68609496
61	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.68103944
62	negative regulation of JUN kinase activity (GO:0043508)	2.67961366
63	preassembly of GPI anchor in ER membrane (GO:0016254)	2.67490229
64	rRNA methylation (GO:0031167)	2.66177000
65	nonmotile primary cilium assembly (GO:0035058)	2.65797196
66	epithelial cilium movement (GO:0003351)	2.65624458
67	DNA deamination (GO:0045006)	2.62018239
68	transepithelial transport (GO:0070633)	2.61289884
69	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.61217911
70	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.60801382
71	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.60801382
72	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.60801382
73	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.58647556
74	C-terminal protein amino acid modification (GO:0018410)	2.56950244
75	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.56896746
76	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.56896746
77	C4-dicarboxylate transport (GO:0015740)	2.56698330
78	termination of RNA polymerase III transcription (GO:0006386)	2.53963120
79	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.53963120
80	maturation of 5.8S rRNA (GO:0000460)	2.53705023
81	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.53446248
82	regulation of cellular amino acid metabolic process (GO:0006521)	2.52610657
83	indolalkylamine metabolic process (GO:0006586)	2.52042142
84	C-terminal protein lipidation (GO:0006501)	2.51479054
85	tryptophan metabolic process (GO:0006568)	2.51288831
86	centriole replication (GO:0007099)	2.50015962
87	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.49040765
88	regulation of collateral sprouting (GO:0048670)	2.48766088
89	cellular biogenic amine catabolic process (GO:0042402)	2.48692127
90	amine catabolic process (GO:0009310)	2.48692127
91	organelle disassembly (GO:1903008)	2.48491586
92	electron transport chain (GO:0022900)	2.47838355
93	polyol catabolic process (GO:0046174)	2.47616355
94	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.46131705
95	S-adenosylmethionine metabolic process (GO:0046500)	2.44600362
96	respiratory electron transport chain (GO:0022904)	2.44120559
97	mannosylation (GO:0097502)	2.43919208
98	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.43218235
99	signal peptide processing (GO:0006465)	2.41826960
100	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.39116689

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.14059114
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.87727591
3	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.86304236
4	VDR_22108803_ChIP-Seq_LS180_Human	2.82561572
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.82228883
6	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.66958824
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.57133336
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.52994583
9	FUS_26573619_Chip-Seq_HEK293_Human	2.48540744
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.43862443
11	EWS_26573619_Chip-Seq_HEK293_Human	2.39249818
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.37306149
13	P300_19829295_ChIP-Seq_ESCs_Human	2.31519262
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.28281717
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.27031244
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.19346733
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.10152707
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.99221947
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.95262329
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.92997460
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.88946077
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.83669487
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79124231
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.76288832
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.74315847
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.72575310
27	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.67739459
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.67693740
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65381328
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.65179807
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.63726034
32	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63521381
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.61782095
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.61782095
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.59998278
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58756692
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.57853591
38	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.54087350
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.49052557
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48828330
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48031991
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.47758515
43	EZH2_22144423_ChIP-Seq_EOC_Human	1.47702680
44	TCF4_22108803_ChIP-Seq_LS180_Human	1.46220630
45	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.46139745
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44357461
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.44026395
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.44026395
49	AR_25329375_ChIP-Seq_VCAP_Human	1.43970070
50	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.38353621
51	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37905266
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.37538647
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35907126
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.35526037
55	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.34909526
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33829353
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.31603411
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31471384
59	STAT3_23295773_ChIP-Seq_U87_Human	1.27161584
60	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.26232346
61	VDR_23849224_ChIP-Seq_CD4+_Human	1.24195341
62	MYC_18940864_ChIP-ChIP_HL60_Human	1.23234681
63	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.23201939
64	TCF4_23295773_ChIP-Seq_U87_Human	1.22527799
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.22028452
66	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.21266655
67	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.21141660
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.19137139
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.19137139
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18647774
71	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18323356
72	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.18239614
73	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.15953479
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15779508
75	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.12373406
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12004878
77	P53_22387025_ChIP-Seq_ESCs_Mouse	1.11941099
78	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.10179676
79	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.10032837
80	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09633337
81	CDX2_22108803_ChIP-Seq_LS180_Human	1.09316110
82	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08254242
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08121448
84	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07881216
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06801711
86	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.05503654
87	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.04788357
88	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.03385872
89	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03385872
90	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02517716
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02418374
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01693343
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01263545
94	NCOR_22424771_ChIP-Seq_293T_Human	1.01103301
95	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.00132549
96	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.99088637
97	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.98862381
98	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98676640
99	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97203869
100	JUN_21703547_ChIP-Seq_K562_Human	0.97137986

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	3.53773438
2	MP0003880_abnormal_central_pattern	3.15450270
3	MP0003195_calcinosis	2.96142164
4	MP0001968_abnormal_touch/_nociception	2.92323867
5	MP0002102_abnormal_ear_morphology	2.83383427
6	MP0008877_abnormal_DNA_methylation	2.51436839
7	MP0000372_irregular_coat_pigmentation	2.46627345
8	MP0005367_renal/urinary_system_phenotyp	2.43200357
9	MP0000516_abnormal_urinary_system	2.43200357
10	MP0005084_abnormal_gallbladder_morpholo	2.16057083
11	MP0005551_abnormal_eye_electrophysiolog	2.02434666
12	MP0006072_abnormal_retinal_apoptosis	1.99228601
13	MP0008872_abnormal_physiological_respon	1.96698654
14	MP0004142_abnormal_muscle_tone	1.93123145
15	MP0006054_spinal_hemorrhage	1.86063696
16	MP0005075_abnormal_melanosome_morpholog	1.82615956
17	MP0003950_abnormal_plasma_membrane	1.81362964
18	MP0002163_abnormal_gland_morphology	1.77758382
19	MP0006276_abnormal_autonomic_nervous	1.76132092
20	MP0008875_abnormal_xenobiotic_pharmacok	1.68865359
21	MP0002938_white_spotting	1.67935548
22	MP0003646_muscle_fatigue	1.67033814
23	MP0003136_yellow_coat_color	1.64703808
24	MP0005253_abnormal_eye_physiology	1.64407748
25	MP0003787_abnormal_imprinting	1.60732961
26	MP0000631_abnormal_neuroendocrine_gland	1.58244301
27	MP0001986_abnormal_taste_sensitivity	1.56922990
28	MP0005408_hypopigmentation	1.56198753
29	MP0000569_abnormal_digit_pigmentation	1.53380285
30	MP0003011_delayed_dark_adaptation	1.51574829
31	MP0005645_abnormal_hypothalamus_physiol	1.51299645
32	MP0002090_abnormal_vision	1.50306692
33	MP0006292_abnormal_olfactory_placode	1.49955780
34	MP0005379_endocrine/exocrine_gland_phen	1.49335504
35	MP0009046_muscle_twitch	1.49016693
36	MP0000427_abnormal_hair_cycle	1.45340469
37	MP0005171_absent_coat_pigmentation	1.44784371
38	MP0002751_abnormal_autonomic_nervous	1.42524081
39	MP0002837_dystrophic_cardiac_calcinosis	1.42485574
40	MP0002234_abnormal_pharynx_morphology	1.37203909
41	MP0008058_abnormal_DNA_repair	1.34869701
42	MP0001984_abnormal_olfaction	1.34281310
43	MP0002272_abnormal_nervous_system	1.32458422
44	MP0005646_abnormal_pituitary_gland	1.32185809
45	MP0003186_abnormal_redox_activity	1.31907249
46	MP0002876_abnormal_thyroid_physiology	1.31327142
47	MP0002638_abnormal_pupillary_reflex	1.28436834
48	MP0009745_abnormal_behavioral_response	1.23582801
49	MP0005389_reproductive_system_phenotype	1.23049655
50	MP0004885_abnormal_endolymph	1.22020034
51	MP0004043_abnormal_pH_regulation	1.17973078
52	MP0005174_abnormal_tail_pigmentation	1.17834562
53	MP0003122_maternal_imprinting	1.16044259
54	MP0001485_abnormal_pinna_reflex	1.13330397
55	MP0002095_abnormal_skin_pigmentation	1.09491771
56	MP0004147_increased_porphyrin_level	1.09115146
57	MP0002160_abnormal_reproductive_system	1.08613175
58	MP0002282_abnormal_trachea_morphology	1.07967382
59	MP0005195_abnormal_posterior_eye	1.07813458
60	MP0005410_abnormal_fertilization	1.07389362
61	MP0005423_abnormal_somatic_nervous	1.06888000
62	MP0003121_genomic_imprinting	1.06484347
63	MP0002254_reproductive_system_inflammat	1.06331706
64	MP0001486_abnormal_startle_reflex	1.06217321
65	MP0000538_abnormal_urinary_bladder	1.06014338
66	MP0003937_abnormal_limbs/digits/tail_de	1.04826913
67	MP0001293_anophthalmia	1.03959840
68	MP0002557_abnormal_social/conspecific_i	1.03589797
69	MP0002735_abnormal_chemical_nociception	1.03249000
70	MP0005187_abnormal_penis_morphology	1.01130001
71	MP0001905_abnormal_dopamine_level	1.00490662
72	MP0001764_abnormal_homeostasis	0.99015258
73	MP0009697_abnormal_copulation	0.98410814
74	MP0001324_abnormal_eye_pigmentation	0.97825408
75	MP0000778_abnormal_nervous_system	0.97788298
76	MP0001970_abnormal_pain_threshold	0.96746569
77	MP0004133_heterotaxia	0.95593817
78	MP0000015_abnormal_ear_pigmentation	0.95523736
79	MP0001119_abnormal_female_reproductive	0.94963684
80	MP0001919_abnormal_reproductive_system	0.91801738
81	MP0002233_abnormal_nose_morphology	0.91143834
82	MP0008995_early_reproductive_senescence	0.91117279
83	MP0005360_urolithiasis	0.90671277
84	MP0003755_abnormal_palate_morphology	0.90328800
85	MP0001529_abnormal_vocalization	0.86489991
86	MP0002752_abnormal_somatic_nervous	0.85057477
87	MP0004484_altered_response_of	0.84529547
88	MP0010386_abnormal_urinary_bladder	0.83894740
89	MP0002909_abnormal_adrenal_gland	0.83795586
90	MP0000647_abnormal_sebaceous_gland	0.80999440
91	MP0010329_abnormal_lipoprotein_level	0.80877997
92	MP0001501_abnormal_sleep_pattern	0.80821598
93	MP0008789_abnormal_olfactory_epithelium	0.80402857
94	MP0002067_abnormal_sensory_capabilities	0.79739821
95	MP0003718_maternal_effect	0.79013454
96	MP0003786_premature_aging	0.78850646
97	MP0001929_abnormal_gametogenesis	0.77190962
98	MP0000049_abnormal_middle_ear	0.75992953
99	MP0004215_abnormal_myocardial_fiber	0.75274513
100	MP0003698_abnormal_male_reproductive	0.75101473

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.46067068
2	Pancreatic fibrosis (HP:0100732)	4.17523145
3	Molar tooth sign on MRI (HP:0002419)	4.02343962
4	Abnormality of midbrain morphology (HP:0002418)	4.02343962
5	True hermaphroditism (HP:0010459)	3.91246362
6	Acute necrotizing encephalopathy (HP:0006965)	3.52093974
7	Septo-optic dysplasia (HP:0100842)	3.47394280
8	Acute encephalopathy (HP:0006846)	3.39580571
9	Progressive macrocephaly (HP:0004481)	3.36760018
10	Medial flaring of the eyebrow (HP:0010747)	3.20476125
11	Mitochondrial inheritance (HP:0001427)	3.15015360
12	Colon cancer (HP:0003003)	2.98971814
13	Abnormal mitochondria in muscle tissue (HP:0008316)	2.97932296
14	Hyperventilation (HP:0002883)	2.95241240
15	Nephronophthisis (HP:0000090)	2.95208442
16	3-Methylglutaconic aciduria (HP:0003535)	2.91644494
17	Increased CSF lactate (HP:0002490)	2.90245085
18	Chronic hepatic failure (HP:0100626)	2.89337279
19	Cystic liver disease (HP:0006706)	2.84806583
20	Abnormality of the renal cortex (HP:0011035)	2.79479344
21	Methylmalonic acidemia (HP:0002912)	2.73791689
22	Bile duct proliferation (HP:0001408)	2.73712141
23	Abnormal biliary tract physiology (HP:0012439)	2.73712141
24	Optic nerve hypoplasia (HP:0000609)	2.71520318
25	Neoplasm of the adrenal cortex (HP:0100641)	2.70935211
26	Congenital, generalized hypertrichosis (HP:0004540)	2.70782216
27	Gait imbalance (HP:0002141)	2.69472285
28	Increased hepatocellular lipid droplets (HP:0006565)	2.67882385
29	Bifid tongue (HP:0010297)	2.64593755
30	Congenital primary aphakia (HP:0007707)	2.63713389
31	Renal cortical cysts (HP:0000803)	2.62014228
32	Abnormality of the renal medulla (HP:0100957)	2.61214663
33	Congenital stationary night blindness (HP:0007642)	2.60458790
34	Lipid accumulation in hepatocytes (HP:0006561)	2.51501669
35	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.47690577
36	Hepatocellular necrosis (HP:0001404)	2.45366410
37	Nephrogenic diabetes insipidus (HP:0009806)	2.44750647
38	Type II lissencephaly (HP:0007260)	2.42872307
39	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.41706696
40	Abolished electroretinogram (ERG) (HP:0000550)	2.39869660
41	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.37214017
42	Sclerocornea (HP:0000647)	2.36257796
43	Optic disc pallor (HP:0000543)	2.35827773
44	Occipital encephalocele (HP:0002085)	2.34647920
45	Genital tract atresia (HP:0001827)	2.34282585
46	Keratoconus (HP:0000563)	2.32395400
47	Increased corneal curvature (HP:0100692)	2.32395400
48	Vaginal atresia (HP:0000148)	2.30636328
49	Cerebral edema (HP:0002181)	2.28709341
50	Intestinal atresia (HP:0011100)	2.27033808
51	Abnormality of the labia minora (HP:0012880)	2.18832273
52	Methylmalonic aciduria (HP:0012120)	2.13467606
53	Abnormal rod and cone electroretinograms (HP:0008323)	2.13328039
54	Growth hormone deficiency (HP:0000824)	2.13070890
55	Adrenal hypoplasia (HP:0000835)	2.11611989
56	Chorioretinal atrophy (HP:0000533)	2.11194069
57	Anencephaly (HP:0002323)	2.10827779
58	Poor coordination (HP:0002370)	2.08561798
59	Tubular atrophy (HP:0000092)	2.08473952
60	Hyperglycinemia (HP:0002154)	2.06605488
61	Postaxial hand polydactyly (HP:0001162)	2.06480398
62	Male pseudohermaphroditism (HP:0000037)	2.04841450
63	Hepatic necrosis (HP:0002605)	2.02657046
64	Renal Fanconi syndrome (HP:0001994)	2.02563901
65	Decreased central vision (HP:0007663)	2.02003996
66	Congenital hepatic fibrosis (HP:0002612)	2.01139760
67	Increased serum lactate (HP:0002151)	2.00567490
68	Postaxial foot polydactyly (HP:0001830)	2.00553648
69	Broad-based gait (HP:0002136)	1.98960099
70	Dandy-Walker malformation (HP:0001305)	1.91917054
71	Abnormality of the ileum (HP:0001549)	1.91192325
72	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.90455119
73	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.89373822
74	Absent septum pellucidum (HP:0001331)	1.88752556
75	Exertional dyspnea (HP:0002875)	1.86844037
76	Stenosis of the external auditory canal (HP:0000402)	1.86299896
77	Hypothermia (HP:0002045)	1.85781151
78	Abnormality of renal resorption (HP:0011038)	1.85328476
79	Oculomotor apraxia (HP:0000657)	1.85052904
80	Polydipsia (HP:0001959)	1.84928870
81	Abnormal drinking behavior (HP:0030082)	1.84928870
82	Focal motor seizures (HP:0011153)	1.84310419
83	Attenuation of retinal blood vessels (HP:0007843)	1.84157000
84	Furrowed tongue (HP:0000221)	1.82954051
85	Lactic acidosis (HP:0003128)	1.80339439
86	Preaxial hand polydactyly (HP:0001177)	1.79226350
87	Abnormality of the septum pellucidum (HP:0007375)	1.78902966
88	Lethargy (HP:0001254)	1.78554477
89	Abnormality of alanine metabolism (HP:0010916)	1.78314398
90	Hyperalaninemia (HP:0003348)	1.78314398
91	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.78314398
92	Pendular nystagmus (HP:0012043)	1.77438928
93	Astigmatism (HP:0000483)	1.76722267
94	Meckel diverticulum (HP:0002245)	1.76169986
95	Pancreatic islet-cell hyperplasia (HP:0004510)	1.75674786
96	Lissencephaly (HP:0001339)	1.74197853
97	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.73385639
98	Small hand (HP:0200055)	1.73069159
99	Abnormality of serum amino acid levels (HP:0003112)	1.71452068
100	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.70223281

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NUAK1	3.90386992
2	TRIM28	3.77693293
3	FRK	3.61161164
4	INSRR	3.43110115
5	CASK	2.95101263
6	MAP4K2	2.88025007
7	WNK3	2.46100625
8	VRK2	2.33893863
9	BCR	2.23683326
10	EIF2AK3	2.21853772
11	STK16	2.19543348
12	TNIK	2.19540518
13	TAF1	2.09767167
14	BMPR1B	2.06348445
15	STK39	1.94558559
16	SIK3	1.69066235
17	MST4	1.64655136
18	NEK1	1.62469113
19	MAP3K12	1.61561562
20	ZAK	1.55984145
21	ACVR1B	1.55442289
22	OXSR1	1.53386788
23	MAPK13	1.51852738
24	DYRK2	1.51427902
25	MKNK2	1.45895694
26	PLK2	1.43741201
27	ERBB3	1.41382181
28	ADRBK2	1.39155950
29	PAK3	1.37239982
30	CSNK1G3	1.33016157
31	EIF2AK1	1.30271923
32	BUB1	1.28697557
33	PINK1	1.26404365
34	CSNK1G2	1.23845888
35	WNK4	1.21597190
36	MKNK1	1.21237424
37	GRK1	1.20416973
38	CSNK1G1	1.20223113
39	EPHA4	1.16336602
40	CSNK1A1L	1.08854843
41	AKT3	1.00485565
42	PLK3	0.96790694
43	MAP3K4	0.92964722
44	MARK1	0.91607768
45	MAPKAPK5	0.90815265
46	VRK1	0.86985310
47	TAOK3	0.86729897
48	NME1	0.86438649
49	PLK4	0.77163034
50	LIMK1	0.75898564
51	MINK1	0.73148379
52	PRKCE	0.71507093
53	SRPK1	0.68133651
54	BCKDK	0.67163115
55	PKN1	0.63692920
56	PHKG1	0.57860090
57	PHKG2	0.57860090
58	BRSK2	0.57359717
59	DYRK3	0.56970357
60	FER	0.56419434
61	DYRK1A	0.54540939
62	STK38L	0.53612631
63	GRK5	0.52599270
64	PRKCG	0.52155825
65	CDK19	0.48877937
66	EPHB2	0.47923401
67	ERBB4	0.47649811
68	ROCK1	0.47393894
69	MYLK	0.46373162
70	ADRBK1	0.45306615
71	DAPK1	0.45237706
72	KSR1	0.44353449
73	FGFR2	0.43003296
74	MAP2K7	0.42504920
75	TIE1	0.39746264
76	MUSK	0.36971035
77	NTRK3	0.36803649
78	DAPK3	0.35677379
79	CAMKK2	0.35648828
80	TGFBR1	0.34961407
81	EIF2AK2	0.34568386
82	TLK1	0.34400517
83	PBK	0.34190105
84	PRKCI	0.33534666
85	CAMK2A	0.32826928
86	NLK	0.30893599
87	CSNK1A1	0.30150684
88	PRKCQ	0.28901911
89	PRKACA	0.28532673
90	PTK2B	0.28010372
91	DAPK2	0.27807025
92	BMPR2	0.27201013
93	NTRK2	0.25993320
94	YES1	0.25347802
95	PLK1	0.25151360
96	RPS6KA4	0.25039777
97	PIM2	0.24946258
98	CHEK2	0.24583476
99	CSNK1D	0.23391435
100	IGF1R	0.22099817

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.92964446
2	Proteasome_Homo sapiens_hsa03050	3.58893641
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.25527544
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.73984131
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.70710696
6	Parkinsons disease_Homo sapiens_hsa05012	2.64197736
7	RNA polymerase_Homo sapiens_hsa03020	2.36058076
8	Propanoate metabolism_Homo sapiens_hsa00640	2.34021162
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.21606303
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.16438149
11	Phototransduction_Homo sapiens_hsa04744	2.13671968
12	RNA degradation_Homo sapiens_hsa03018	2.05102103
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.96981145
14	Basal transcription factors_Homo sapiens_hsa03022	1.85092232
15	Caffeine metabolism_Homo sapiens_hsa00232	1.79196677
16	Huntingtons disease_Homo sapiens_hsa05016	1.73927556
17	Ribosome_Homo sapiens_hsa03010	1.72663259
18	Alzheimers disease_Homo sapiens_hsa05010	1.72229308
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.71482879
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.67217988
21	Butanoate metabolism_Homo sapiens_hsa00650	1.61147982
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.55806529
23	Homologous recombination_Homo sapiens_hsa03440	1.54816316
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.47334660
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.43250064
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.38950005
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.34103047
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.30952407
29	Chemical carcinogenesis_Homo sapiens_hsa05204	1.26981666
30	Nicotine addiction_Homo sapiens_hsa05033	1.23078489
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.23056710
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.22471474
33	Peroxisome_Homo sapiens_hsa04146	1.20902862
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.19397581
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.18443923
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.14125221
37	One carbon pool by folate_Homo sapiens_hsa00670	1.13063385
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.10042768
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.10033135
40	Non-homologous end-joining_Homo sapiens_hsa03450	1.07890435
41	Collecting duct acid secretion_Homo sapiens_hsa04966	1.07741650
42	Circadian rhythm_Homo sapiens_hsa04710	1.05987448
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.05724187
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.04866698
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.04837426
46	Tryptophan metabolism_Homo sapiens_hsa00380	1.01687646
47	Asthma_Homo sapiens_hsa05310	1.00712269
48	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.97959901
49	Regulation of autophagy_Homo sapiens_hsa04140	0.87515794
50	RNA transport_Homo sapiens_hsa03013	0.86954244
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82813248
52	Olfactory transduction_Homo sapiens_hsa04740	0.82671861
53	Nucleotide excision repair_Homo sapiens_hsa03420	0.80833037
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.80223672
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78277797
56	Metabolic pathways_Homo sapiens_hsa01100	0.72583460
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.71681715
58	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.71111376
59	Retinol metabolism_Homo sapiens_hsa00830	0.69707771
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.68953965
61	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.68751840
62	Sulfur metabolism_Homo sapiens_hsa00920	0.68179458
63	Mineral absorption_Homo sapiens_hsa04978	0.67226079
64	Glutamatergic synapse_Homo sapiens_hsa04724	0.66513510
65	Fatty acid elongation_Homo sapiens_hsa00062	0.65544429
66	Purine metabolism_Homo sapiens_hsa00230	0.63925538
67	Fatty acid degradation_Homo sapiens_hsa00071	0.62972562
68	Glutathione metabolism_Homo sapiens_hsa00480	0.62031520
69	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.59832616
70	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.58378719
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.54953933
72	Morphine addiction_Homo sapiens_hsa05032	0.54668989
73	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.52286700
74	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.50468550
75	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.49404742
76	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.49344373
77	Folate biosynthesis_Homo sapiens_hsa00790	0.48908107
78	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.48101085
79	Fatty acid metabolism_Homo sapiens_hsa01212	0.46842159
80	Pyruvate metabolism_Homo sapiens_hsa00620	0.46720750
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.45850430
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45352334
83	Sulfur relay system_Homo sapiens_hsa04122	0.45151525
84	Taste transduction_Homo sapiens_hsa04742	0.43745974
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.42077595
86	Allograft rejection_Homo sapiens_hsa05330	0.41036015
87	Spliceosome_Homo sapiens_hsa03040	0.40655779
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39479155
89	Circadian entrainment_Homo sapiens_hsa04713	0.37735027
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37441370
91	p53 signaling pathway_Homo sapiens_hsa04115	0.36983415
92	Selenocompound metabolism_Homo sapiens_hsa00450	0.35654099
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.35224552
94	Mismatch repair_Homo sapiens_hsa03430	0.35060325
95	Salivary secretion_Homo sapiens_hsa04970	0.34390012
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33946153
97	Basal cell carcinoma_Homo sapiens_hsa05217	0.33809900
98	Amphetamine addiction_Homo sapiens_hsa05031	0.30976449
99	Dopaminergic synapse_Homo sapiens_hsa04728	0.29692506
100	GABAergic synapse_Homo sapiens_hsa04727	0.29548942

RPL34P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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