ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	8.92151001
2	* translational elongation (GO:0006414)	8.88550720
3	* cotranslational protein targeting to membrane (GO:0006613)	8.77184847
4	* protein targeting to ER (GO:0045047)	8.75632021
5	* establishment of protein localization to endoplasmic reticulum (GO:0072599)	8.37919392
6	maturation of SSU-rRNA (GO:0030490)	8.30381653
7	* protein localization to endoplasmic reticulum (GO:0070972)	8.17925241
8	* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	8.14909043
9	* viral life cycle (GO:0019058)	8.13546847
10	* cellular protein complex disassembly (GO:0043624)	8.12598863
11	* translational initiation (GO:0006413)	7.59672415
12	* protein complex disassembly (GO:0043241)	7.06959709
13	* macromolecular complex disassembly (GO:0032984)	6.60288610
14	* ribosomal large subunit biogenesis (GO:0042273)	6.21929410
15	* protein targeting to membrane (GO:0006612)	5.84582302
16	* nuclear-transcribed mRNA catabolic process (GO:0000956)	5.75501204
17	* mRNA catabolic process (GO:0006402)	5.46156693
18	* translation (GO:0006412)	5.35973854
19	chaperone-mediated protein transport (GO:0072321)	5.10130690
20	* RNA catabolic process (GO:0006401)	5.06281618
21	* ribonucleoprotein complex biogenesis (GO:0022613)	5.01596910
22	respiratory electron transport chain (GO:0022904)	4.77331852
23	electron transport chain (GO:0022900)	4.66667978
24	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.58472578
25	formation of translation preinitiation complex (GO:0001731)	4.14130229
26	DNA deamination (GO:0045006)	4.03729661
27	* rRNA processing (GO:0006364)	3.98916217
28	* establishment of protein localization to membrane (GO:0090150)	3.94774098
29	* rRNA metabolic process (GO:0016072)	3.84465886
30	* cellular component biogenesis (GO:0044085)	3.72808582
31	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.66934894
32	protein complex biogenesis (GO:0070271)	3.63396432
33	mitochondrial respiratory chain complex assembly (GO:0033108)	3.61719417
34	regulation of mitochondrial translation (GO:0070129)	3.61190996
35	* protein targeting (GO:0006605)	3.57039066
36	NADH dehydrogenase complex assembly (GO:0010257)	3.55996145
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.55996145
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.55996145
39	* establishment of protein localization to organelle (GO:0072594)	3.54045522
40	telomere maintenance via semi-conservative replication (GO:0032201)	3.46922906
41	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.45917130
42	ATP synthesis coupled proton transport (GO:0015986)	3.45917130
43	DNA strand elongation involved in DNA replication (GO:0006271)	3.44331245
44	inner mitochondrial membrane organization (GO:0007007)	3.38429931
45	ATP biosynthetic process (GO:0006754)	3.38094644
46	protein neddylation (GO:0045116)	3.30399771
47	ncRNA 3-end processing (GO:0043628)	3.25832432
48	DNA strand elongation (GO:0022616)	3.24502106
49	establishment of integrated proviral latency (GO:0075713)	3.23449893
50	spliceosomal snRNP assembly (GO:0000387)	3.21114705
51	oxidative phosphorylation (GO:0006119)	3.20380001
52	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.20097787
53	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.19959565
54	protein targeting to mitochondrion (GO:0006626)	3.18818127
55	spliceosomal complex assembly (GO:0000245)	3.16561996
56	rRNA modification (GO:0000154)	3.15674147
57	establishment of protein localization to mitochondrion (GO:0072655)	3.06360018
58	negative regulation of RNA splicing (GO:0033119)	3.05386209
59	DNA unwinding involved in DNA replication (GO:0006268)	3.03901395
60	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.02828604
61	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.01480464
62	telomere maintenance via recombination (GO:0000722)	2.99794049
63	* protein localization to membrane (GO:0072657)	2.99285325
64	protein localization to mitochondrion (GO:0070585)	2.96248560
65	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.94837176
66	termination of RNA polymerase III transcription (GO:0006386)	2.94837176
67	hydrogen ion transmembrane transport (GO:1902600)	2.94811765
68	DNA replication initiation (GO:0006270)	2.93007411
69	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.85707185
70	7-methylguanosine mRNA capping (GO:0006370)	2.83415738
71	* cellular component disassembly (GO:0022411)	2.82564466
72	mitotic recombination (GO:0006312)	2.82193639
73	proteasome assembly (GO:0043248)	2.79634275
74	DNA replication-independent nucleosome assembly (GO:0006336)	2.79172926
75	DNA replication-independent nucleosome organization (GO:0034724)	2.79172926
76	pseudouridine synthesis (GO:0001522)	2.77927211
77	aerobic respiration (GO:0009060)	2.77854948
78	intracellular protein transmembrane import (GO:0044743)	2.76373645
79	RNA capping (GO:0036260)	2.76124045
80	7-methylguanosine RNA capping (GO:0009452)	2.76124045
81	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.75853095
82	ribosome biogenesis (GO:0042254)	2.72932967
83	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.72755924
84	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.72755924
85	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.71593836
86	* gene expression (GO:0010467)	2.71049514
87	mitochondrial transport (GO:0006839)	2.69909788
88	telomere maintenance via telomere lengthening (GO:0010833)	2.68827112
89	UTP biosynthetic process (GO:0006228)	2.68640546
90	histone exchange (GO:0043486)	2.67965183
91	kinetochore organization (GO:0051383)	2.66420049
92	nucleoside triphosphate biosynthetic process (GO:0009142)	2.66019797
93	* ncRNA processing (GO:0034470)	2.64607541
94	establishment of viral latency (GO:0019043)	2.64407512
95	chromatin remodeling at centromere (GO:0031055)	2.63077085
96	CENP-A containing nucleosome assembly (GO:0034080)	2.62983093
97	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.62781628
98	transcription-coupled nucleotide-excision repair (GO:0006283)	2.61498468
99	histone mRNA metabolic process (GO:0008334)	2.61077428
100	GTP biosynthetic process (GO:0006183)	2.60903074
101	* protein localization to organelle (GO:0033365)	2.60594329
102	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.59566048
103	termination of RNA polymerase II transcription (GO:0006369)	2.57574741
104	ribonucleoprotein complex assembly (GO:0022618)	2.56734297
105	ribosome assembly (GO:0042255)	2.56517325
106	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.56038399
107	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.52610268
108	negative regulation of ligase activity (GO:0051352)	2.52610268
109	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.50235758
110	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.48156630
111	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.48031480
112	folic acid-containing compound biosynthetic process (GO:0009396)	2.47784220
113	DNA replication checkpoint (GO:0000076)	2.46683612
114	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.46123313
115	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.46123313
116	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)	2.46076765
117	mRNA splicing, via spliceosome (GO:0000398)	2.46076765
118	RNA splicing, via transesterification reactions (GO:0000375)	2.46056608
119	* ncRNA metabolic process (GO:0034660)	2.45692782
120	termination of RNA polymerase I transcription (GO:0006363)	2.45206383
121	regulation of protein heterodimerization activity (GO:0043497)	2.44645933
122	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.44427215
123	DNA-templated transcription, termination (GO:0006353)	2.44218059
124	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.43602636
125	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.42888692
126	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.42888692
127	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.42875063
128	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.42000865
129	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.41944862
130	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.41944862
131	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.41944862
132	ribonucleoprotein complex subunit organization (GO:0071826)	2.41790422
133	* viral transcription (GO:0019083)	10.9763408
134	* translational termination (GO:0006415)	10.5201548
135	ribosomal small subunit assembly (GO:0000028)	10.0199480
136	ribosomal small subunit biogenesis (GO:0042274)	10.0033368

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.16493014
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	5.01823715
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.45616946
4	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	4.04027071
5	* MYC_19079543_ChIP-ChIP_MESCs_Mouse	3.74953461
6	* GABP_17652178_ChIP-ChIP_JURKAT_Human	3.32304454
7	* EST1_17652178_ChIP-ChIP_JURKAT_Human	3.29322521
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.09157652
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.07847960
10	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.91654200
11	* E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.83057972
12	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.82035994
13	* XRN2_22483619_ChIP-Seq_HELA_Human	2.81900745
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.70200768
15	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.68622919
16	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.66860394
17	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.64580883
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.63927639
19	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.59675484
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.58552325
21	* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.52469850
22	TTF2_22483619_ChIP-Seq_HELA_Human	2.36365281
23	* VDR_23849224_ChIP-Seq_CD4+_Human	2.36118815
24	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.32694970
25	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.15808177
26	* DCP1A_22483619_ChIP-Seq_HELA_Human	2.07760117
27	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.07621012
28	FOXP3_21729870_ChIP-Seq_TREG_Human	2.05087495
29	* ELK1_19687146_ChIP-ChIP_HELA_Human	2.04615468
30	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.02661832
31	* TAL1_20887958_ChIP-Seq_HPC-7_Mouse	2.02358555
32	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.98995865
33	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.93005940
34	* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.77190024
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.68467734
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.57544251
37	* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.53502942
38	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.52653491
39	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.51174529
40	MYC_22102868_ChIP-Seq_BL_Human	1.50664696
41	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.50622521
42	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.50321097
43	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.46458144
44	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.45616315
45	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.43242671
46	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.43052446
47	VDR_21846776_ChIP-Seq_THP-1_Human	1.41421672
48	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.39695143
49	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.39626302
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.37648809
51	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.37498863
52	CIITA_25753668_ChIP-Seq_RAJI_Human	1.37050956
53	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.36068591
54	* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.35596695
55	* ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.35499655
56	AR_21909140_ChIP-Seq_LNCAP_Human	1.30934724
57	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.30535784
58	* MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.29902144
59	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.29660112
60	MYC_18940864_ChIP-ChIP_HL60_Human	1.27350783
61	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.26824168
62	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.23559533
63	* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.21814037
64	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.19976699
65	SPI1_23547873_ChIP-Seq_NB4_Human	1.18214317
66	KDM5A_27292631_Chip-Seq_BREAST_Human	1.15602992
67	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.15355572
68	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.14487509
69	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.12215401
70	* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.11399563
71	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.10982411
72	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.09154242
73	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.08953216
74	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.07948819
75	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.06706816
76	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.05500903
77	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.05244706
78	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.04196446
79	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.03111349
80	* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.02903782
81	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.01569328
82	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.01066628
83	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.00552746
84	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.00173872
85	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.00105121
86	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.99735426
87	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.99568165
88	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.98160332
89	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.97918220
90	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.97683482
91	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.97039345
92	* ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.96930754
93	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.96196974
94	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.95893729
95	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.94375053
96	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.93553516
97	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.93352086
98	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.93038874
99	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.92293428
100	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.91277420
101	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.90009998
102	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.87309249
103	MAF_26560356_Chip-Seq_TH2_Human	0.87093090
104	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.86421466
105	* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.85181741
106	TFEB_21752829_ChIP-Seq_HELA_Human	0.84649024
107	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.84229831
108	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.83938818
109	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.83834816
110	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.83510487
111	* PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.83235133
112	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.82626346
113	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.82051723
114	ELF5_23300383_ChIP-Seq_T47D_Human	0.81809321
115	ZNF263_19887448_ChIP-Seq_K562_Human	0.81366842
116	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.81177321
117	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.81177321
118	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.81177321
119	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.81109464
120	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.80118736

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.91527917
2	MP0003693_abnormal_embryo_hatching	4.06614135
3	MP0004957_abnormal_blastocyst_morpholog	3.54011983
4	MP0006292_abnormal_olfactory_placode	3.48749307
5	MP0010094_abnormal_chromosome_stability	2.76833195
6	MP0003077_abnormal_cell_cycle	2.70872711
7	MP0003111_abnormal_nucleus_morphology	2.56672480
8	MP0008057_abnormal_DNA_replication	2.32818800
9	MP0004381_abnormal_hair_follicle	2.19201004
10	MP0000566_synostosis	2.12137291
11	MP0001293_anophthalmia	2.05499801
12	MP0002396_abnormal_hematopoietic_system	1.99932836
13	MP0003763_abnormal_thymus_physiology	1.93655976
14	MP0008932_abnormal_embryonic_tissue	1.89878066
15	MP0008007_abnormal_cellular_replicative	1.89430164
16	MP0008058_abnormal_DNA_repair	1.86497924
17	MP0000490_abnormal_crypts_of	1.86132197
18	MP0003806_abnormal_nucleotide_metabolis	1.85235921
19	MP0003941_abnormal_skin_development	1.84536817
20	MP0003786_premature_aging	1.79036447
21	MP0002796_impaired_skin_barrier	1.76328030
22	MP0003136_yellow_coat_color	1.73310230
23	MP0010352_gastrointestinal_tract_polyps	1.67714823
24	MP0005174_abnormal_tail_pigmentation	1.64634462
25	MP0009333_abnormal_splenocyte_physiolog	1.64583988
26	MP0003890_abnormal_embryonic-extraembry	1.51789813
27	MP0005501_abnormal_skin_physiology	1.51528474
28	MP0008789_abnormal_olfactory_epithelium	1.49818715
29	MP0000350_abnormal_cell_proliferation	1.43963733
30	MP0001286_abnormal_eye_development	1.43707119
31	MP0001529_abnormal_vocalization	1.42802663
32	MP0006054_spinal_hemorrhage	1.42446421
33	MP0002160_abnormal_reproductive_system	1.42380746
34	MP0002132_abnormal_respiratory_system	1.39403293
35	MP0006036_abnormal_mitochondrial_physio	1.38744355
36	MP0001835_abnormal_antigen_presentation	1.38032483
37	MP0002166_altered_tumor_susceptibility	1.37548313
38	MP0000703_abnormal_thymus_morphology	1.37304338
39	MP0001853_heart_inflammation	1.36588539
40	MP0001346_abnormal_lacrimal_gland	1.35778923
41	MP0001800_abnormal_humoral_immune	1.35070623
42	MP0002398_abnormal_bone_marrow	1.34348523
43	MP0002697_abnormal_eye_size	1.32188710
44	MP0002722_abnormal_immune_system	1.31514625
45	MP0000685_abnormal_immune_system	1.30716428
46	MP0004808_abnormal_hematopoietic_stem	1.30606241
47	MP0001730_embryonic_growth_arrest	1.29850225
48	MP0003315_abnormal_perineum_morphology	1.26596779
49	MP0000049_abnormal_middle_ear	1.26269778
50	MP0006035_abnormal_mitochondrial_morpho	1.25779517
51	MP0003123_paternal_imprinting	1.25520145
52	MP0006072_abnormal_retinal_apoptosis	1.24262749
53	MP0003567_abnormal_fetal_cardiomyocyte	1.23006284
54	MP0003938_abnormal_ear_development	1.22915455
55	MP0002019_abnormal_tumor_incidence	1.22510269
56	MP0000465_gastrointestinal_hemorrhage	1.22353271
57	MP0000372_irregular_coat_pigmentation	1.21303639
58	MP0001216_abnormal_epidermal_layer	1.17623351
59	MP0002098_abnormal_vibrissa_morphology	1.17114073
60	MP0000631_abnormal_neuroendocrine_gland	1.16989197
61	MP0002420_abnormal_adaptive_immunity	1.16662600
62	MP0002095_abnormal_skin_pigmentation	1.16539570
63	MP0003937_abnormal_limbs/digits/tail_de	1.15941064
64	MP0002653_abnormal_ependyma_morphology	1.15606019
65	MP0002452_abnormal_antigen_presenting	1.14341917
66	MP0001819_abnormal_immune_cell	1.14029100
67	MP0000689_abnormal_spleen_morphology	1.13729425
68	MP0002006_tumorigenesis	1.13242661
69	MP0002148_abnormal_hypersensitivity_rea	1.13069320
70	MP0005394_taste/olfaction_phenotype	1.12893946
71	MP0005499_abnormal_olfactory_system	1.12893946
72	MP0002210_abnormal_sex_determination	1.10955498
73	MP0002405_respiratory_system_inflammati	1.10658395
74	MP0000858_altered_metastatic_potential	1.09791741
75	MP0002429_abnormal_blood_cell	1.09390408
76	MP0003436_decreased_susceptibility_to	1.08996135
77	MP0000716_abnormal_immune_system	1.08556925
78	MP0005671_abnormal_response_to	1.07008371
79	MP0002723_abnormal_immune_serum	1.06811338
80	MP0005025_abnormal_response_to	1.06498581
81	MP0005000_abnormal_immune_tolerance	1.06310055
82	MP0010234_abnormal_vibrissa_follicle	1.05936278
83	MP0002277_abnormal_respiratory_mucosa	1.05361457
84	MP0002060_abnormal_skin_morphology	1.05206381
85	MP0010030_abnormal_orbit_morphology	1.04711267
86	MP0009053_abnormal_anal_canal	1.04678504
87	MP0000383_abnormal_hair_follicle	1.03953839
88	MP0000313_abnormal_cell_death	1.03823839
89	MP0005389_reproductive_system_phenotype	1.02478771
90	MP0010155_abnormal_intestine_physiology	1.02386599
91	MP0000537_abnormal_urethra_morphology	1.02363106
92	MP0002938_white_spotting	1.02107781
93	MP0003011_delayed_dark_adaptation	1.01498581
94	MP0004142_abnormal_muscle_tone	1.00829906
95	MP0008995_early_reproductive_senescence	0.99657902
96	MP0001545_abnormal_hematopoietic_system	0.99022393
97	MP0005397_hematopoietic_system_phenotyp	0.99022393
98	MP0001873_stomach_inflammation	0.98989545
99	MP0001188_hyperpigmentation	0.98439936
100	MP0002638_abnormal_pupillary_reflex	0.98226372
101	MP0005075_abnormal_melanosome_morpholog	0.97748968
102	MP0009697_abnormal_copulation	0.95929140
103	MP0009785_altered_susceptibility_to	0.94970186
104	MP0002080_prenatal_lethality	0.94624740
105	MP0000377_abnormal_hair_follicle	0.94012626
106	MP0001697_abnormal_embryo_size	0.93665046
107	MP0001881_abnormal_mammary_gland	0.92197866
108	MP0002234_abnormal_pharynx_morphology	0.92110828
109	MP0002009_preneoplasia	0.91945523
110	MP0001919_abnormal_reproductive_system	0.91307244
111	MP0003942_abnormal_urinary_system	0.91101311
112	MP0002111_abnormal_tail_morphology	0.90936199
113	MP0002233_abnormal_nose_morphology	0.90921982
114	MP0003453_abnormal_keratinocyte_physiol	0.90920334
115	MP0001145_abnormal_male_reproductive	0.89070738
116	MP0003718_maternal_effect	0.87990860
117	MP0003186_abnormal_redox_activity	0.86932165
118	MP0002163_abnormal_gland_morphology	0.85950458
119	MP0009250_abnormal_appendicular_skeleto	0.85082950
120	MP0003866_abnormal_defecation	0.84635144
121	MP0001790_abnormal_immune_system	0.82723940
122	MP0005387_immune_system_phenotype	0.82723940
123	MP0003984_embryonic_growth_retardation	0.82378319
124	MP0002085_abnormal_embryonic_tissue	0.82192420
125	MP0002282_abnormal_trachea_morphology	0.81566953
126	MP0002092_abnormal_eye_morphology	0.81087063
127	MP0002088_abnormal_embryonic_growth/wei	0.80696781
128	MP0004133_heterotaxia	0.80614055
129	MP0010771_integument_phenotype	0.79985722
130	MP0009931_abnormal_skin_appearance	0.79280320
131	MP0001672_abnormal_embryogenesis/_devel	0.78293478
132	MP0005380_embryogenesis_phenotype	0.78293478
133	MP0001485_abnormal_pinna_reflex	0.77488736
134	MP0004947_skin_inflammation	0.77073880
135	MP0000653_abnormal_sex_gland	0.76596249
136	MP0001764_abnormal_homeostasis	0.76376421
137	MP0005023_abnormal_wound_healing	0.76268338
138	MP0000762_abnormal_tongue_morphology	0.76244069
139	MP0002084_abnormal_developmental_patter	0.75585807
140	MP0003755_abnormal_palate_morphology	0.75542433
141	MP0001727_abnormal_embryo_implantation	0.73147139
142	MP0002086_abnormal_extraembryonic_tissu	0.72805796
143	MP0004197_abnormal_fetal_growth/weight/	0.72784692
144	MP0002102_abnormal_ear_morphology	0.72554777
145	MP0000477_abnormal_intestine_morphology	0.71852888
146	MP0005408_hypopigmentation	0.71438915
147	MP0003861_abnormal_nervous_system	0.71436733
148	MP0003121_genomic_imprinting	0.71392739
149	MP0003119_abnormal_digestive_system	0.71384638
150	MP0008877_abnormal_DNA_methylation	0.70832325
151	MP0005379_endocrine/exocrine_gland_phen	0.68837743
152	MP0001929_abnormal_gametogenesis	0.68393721
153	MP0003283_abnormal_digestive_organ	0.67485453
154	MP0005391_vision/eye_phenotype	0.65468799
155	MP0005084_abnormal_gallbladder_morpholo	0.65374111
156	MP0000358_abnormal_cell_content/	0.64204888
157	MP0009672_abnormal_birth_weight	0.62968642
158	MP0001340_abnormal_eyelid_morphology	0.61841796

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	9.42469521
2	* Abnormality of cells of the erythroid lineage (HP:0012130)	8.92775454
3	* Abnormal number of erythroid precursors (HP:0012131)	7.21121027
4	* Macrocytic anemia (HP:0001972)	6.65111598
5	* Pallor (HP:0000980)	6.05659599
6	Abnormal hemoglobin (HP:0011902)	3.97987521
7	Colon cancer (HP:0003003)	3.60186696
8	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.57812499
9	Cerebral edema (HP:0002181)	3.50088006
10	Thrombocytosis (HP:0001894)	3.32360110
11	11 pairs of ribs (HP:0000878)	3.23296133
12	Congenital, generalized hypertrichosis (HP:0004540)	3.20059582
13	Stenosis of the external auditory canal (HP:0000402)	3.17549143
14	Abnormality of reticulocytes (HP:0004312)	3.13430876
15	Absent thumb (HP:0009777)	3.12597002
16	Septo-optic dysplasia (HP:0100842)	3.02520280
17	Increased muscle lipid content (HP:0009058)	2.96239111
18	Aplastic anemia (HP:0001915)	2.93769937
19	Increased hepatocellular lipid droplets (HP:0006565)	2.90893693
20	Oral leukoplakia (HP:0002745)	2.82585779
21	Trismus (HP:0000211)	2.78717614
22	Abnormality of renal resorption (HP:0011038)	2.75434837
23	Acute necrotizing encephalopathy (HP:0006965)	2.74345902
24	* Depressed nasal ridge (HP:0000457)	2.69338214
25	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.67780370
26	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.67780370
27	Multiple enchondromatosis (HP:0005701)	2.65983579
28	Woolly hair (HP:0002224)	2.64268461
29	Mitochondrial inheritance (HP:0001427)	2.64067721
30	Leukodystrophy (HP:0002415)	2.62230207
31	IgM deficiency (HP:0002850)	2.59631946
32	Lactic acidosis (HP:0003128)	2.58089612
33	Microvesicular hepatic steatosis (HP:0001414)	2.57103232
34	Exertional dyspnea (HP:0002875)	2.48629297
35	Asplenia (HP:0001746)	2.46299822
36	Respiratory failure (HP:0002878)	2.45372928
37	Lipid accumulation in hepatocytes (HP:0006561)	2.44235756
38	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.43884938
39	Abnormal mitochondria in muscle tissue (HP:0008316)	2.39528173
40	Abnormality of secondary sexual hair (HP:0009888)	2.36334382
41	Abnormality of the axillary hair (HP:0100134)	2.36334382
42	Respiratory difficulties (HP:0002880)	2.30101105
43	Breast hypoplasia (HP:0003187)	2.30008798
44	Optic disc pallor (HP:0000543)	2.25356485
45	* Migraine (HP:0002076)	2.25218794
46	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.23733711
47	Triphalangeal thumb (HP:0001199)	2.23625792
48	Rough bone trabeculation (HP:0100670)	2.22980059
49	Hepatocellular necrosis (HP:0001404)	2.21808275
50	Abnormality of the parietal bone (HP:0002696)	2.21587142
51	Hypoplasia of the radius (HP:0002984)	2.21569826
52	* Thick lower lip vermilion (HP:0000179)	2.21474750
53	Absent septum pellucidum (HP:0001331)	2.19875109
54	Progressive macrocephaly (HP:0004481)	2.19176824
55	Selective tooth agenesis (HP:0001592)	2.18394841
56	Increased CSF lactate (HP:0002490)	2.18118944
57	Fragile nails (HP:0001808)	2.17652885
58	Glossoptosis (HP:0000162)	2.13145693
59	Rib fusion (HP:0000902)	2.12586491
60	Chronic otitis media (HP:0000389)	2.12567921
61	Hyperphosphaturia (HP:0003109)	2.10936263
62	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.10479604
63	Microretrognathia (HP:0000308)	2.06555762
64	Birth length less than 3rd percentile (HP:0003561)	2.06120327
65	Concave nail (HP:0001598)	2.04380768
66	Carpal bone hypoplasia (HP:0001498)	2.04224714
67	Abnormality of methionine metabolism (HP:0010901)	2.03014658
68	Maternal diabetes (HP:0009800)	2.02853680
69	Abnormality of the septum pellucidum (HP:0007375)	2.02353985
70	Renal Fanconi syndrome (HP:0001994)	2.02190865
71	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.00452764
72	Cleft eyelid (HP:0000625)	1.99710183
73	Missing ribs (HP:0000921)	1.98442701
74	Sparse eyelashes (HP:0000653)	1.97953899
75	Acute encephalopathy (HP:0006846)	1.97319346
76	Partial duplication of thumb phalanx (HP:0009944)	1.95185480
77	Increased intramyocellular lipid droplets (HP:0012240)	1.93654807
78	Parakeratosis (HP:0001036)	1.93171949
79	Elevated erythrocyte sedimentation rate (HP:0003565)	1.91765993
80	Abnormal urine phosphate concentration (HP:0012599)	1.89595841
81	Lethargy (HP:0001254)	1.89559109
82	Bilateral microphthalmos (HP:0007633)	1.87827356
83	Atresia of the external auditory canal (HP:0000413)	1.86225801
84	Horseshoe kidney (HP:0000085)	1.85136402
85	Basal cell carcinoma (HP:0002671)	1.84751789
86	Homocystinuria (HP:0002156)	1.84720420
87	Abnormality of homocysteine metabolism (HP:0010919)	1.84720420
88	Nasolacrimal duct obstruction (HP:0000579)	1.84521169
89	Partial duplication of the phalanx of hand (HP:0009999)	1.84057450
90	Abnormal number of incisors (HP:0011064)	1.82901533
91	Chromsome breakage (HP:0040012)	1.82789632
92	Megaloblastic anemia (HP:0001889)	1.82758691
93	Premature graying of hair (HP:0002216)	1.82733601
94	Myelodysplasia (HP:0002863)	1.82456436
95	Neoplasm of the pancreas (HP:0002894)	1.82439220
96	Glycosuria (HP:0003076)	1.82028865
97	Abnormality of urine glucose concentration (HP:0011016)	1.82028865
98	Abnormality of the preputium (HP:0100587)	1.81997738
99	Hepatic necrosis (HP:0002605)	1.77754068
100	3-Methylglutaconic aciduria (HP:0003535)	1.77598539
101	Amniotic constriction ring (HP:0009775)	1.75984132
102	Abnormality of placental membranes (HP:0011409)	1.75984132
103	Agnosia (HP:0010524)	1.74653807
104	Cellular immunodeficiency (HP:0005374)	1.74594326
105	Meckel diverticulum (HP:0002245)	1.73458870
106	Recurrent bronchitis (HP:0002837)	1.71802750
107	Abnormality of the lacrimal duct (HP:0011481)	1.69248676
108	Esophageal atresia (HP:0002032)	1.68855264
109	Exercise intolerance (HP:0003546)	1.67998708
110	Lymphoma (HP:0002665)	1.67922025
111	Absent radius (HP:0003974)	1.67877878
112	Premature ovarian failure (HP:0008209)	1.67685054
113	Petechiae (HP:0000967)	1.67579750
114	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.66731947
115	Pancytopenia (HP:0001876)	1.66299280
116	Congenital ichthyosiform erythroderma (HP:0007431)	1.65743411
117	Hypoplasia of the pons (HP:0012110)	1.64888236
118	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.64554837
119	Patellar aplasia (HP:0006443)	1.64274582
120	Facial cleft (HP:0002006)	1.63396619
121	Anophthalmia (HP:0000528)	1.63021867
122	Increased serum lactate (HP:0002151)	1.62778979
123	Aplasia cutis congenita (HP:0001057)	1.62353338
124	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.61725367
125	Abnormality of the ileum (HP:0001549)	1.61565001
126	Methylmalonic acidemia (HP:0002912)	1.61071584
127	Abnormality of the pons (HP:0007361)	1.60663249
128	Poikiloderma (HP:0001029)	1.60068053
129	Hypotrichosis (HP:0001006)	1.59701103
130	Abnormal trabecular bone morphology (HP:0100671)	1.59565035
131	Secondary amenorrhea (HP:0000869)	1.59135123
132	Aplasia/Hypoplasia of the patella (HP:0006498)	1.58829948
133	Abnormality of the anterior horn cell (HP:0006802)	1.58615802
134	Degeneration of anterior horn cells (HP:0002398)	1.58615802
135	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.57374618
136	Renal tubular dysfunction (HP:0000124)	1.56132557
137	Type I transferrin isoform profile (HP:0003642)	1.54947164
138	Abnormality of T cells (HP:0002843)	1.54669776
139	Duplication of thumb phalanx (HP:0009942)	1.54427004
140	Squamous cell carcinoma (HP:0002860)	1.53703554
141	Absent forearm bone (HP:0003953)	1.53210251
142	Aplasia involving forearm bones (HP:0009822)	1.53210251
143	Ridged nail (HP:0001807)	1.52542374

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.57351720
2	NME2	5.27152975
3	WEE1	3.32409905
4	BUB1	3.28188071
5	TLK1	3.15427539
6	RPS6KB2	2.88121596
7	LRRK2	2.65781591
8	TAF1	2.61743837
9	MST4	2.46746062
10	SRPK1	2.36344501
11	EEF2K	2.33058451
12	STK16	2.28190477
13	VRK1	2.18439097
14	TGFBR1	2.05673620
15	ZAK	2.03997871
16	CDC7	1.95885032
17	DYRK3	1.91757000
18	PIM2	1.90538802
19	MAP4K1	1.80173540
20	PASK	1.76818590
21	EIF2AK1	1.76503678
22	PNCK	1.57494526
23	MAPKAPK3	1.54962959
24	MAP3K10	1.53708214
25	EIF2AK3	1.50731598
26	NEK1	1.48481475
27	AURKB	1.45141341
28	NEK2	1.38954422
29	RPS6KA4	1.38777789
30	KDR	1.37660096
31	ACVR1B	1.37656440
32	BLK	1.34389330
33	CDK7	1.32185301
34	STK10	1.29040382
35	TESK2	1.25681422
36	MKNK1	1.22193820
37	NUAK1	1.20801082
38	TSSK6	1.20391313
39	NME1	1.19718260
40	ILK	1.19702420
41	BRSK2	1.16840012
42	TEC	1.16389601
43	BTK	1.12263675
44	GRK6	1.05976455
45	PBK	1.03141066
46	MAP3K3	1.01104158
47	PLK1	1.00438462
48	PAK4	0.98767973
49	PIM1	0.97462460
50	FLT3	0.96940602
51	MAPK15	0.95962753
52	CDK4	0.95905737
53	MAP3K8	0.95491573
54	EPHA2	0.93475792
55	CDK19	0.92760272
56	NLK	0.91058917
57	TTK	0.91040025
58	RPS6KA5	0.90685673
59	AURKA	0.89125125
60	TYK2	0.86797764
61	CSNK2A2	0.86107119
62	ATR	0.85813139
63	SCYL2	0.82705278
64	SMG1	0.81257863
65	IKBKB	0.77235598
66	ZAP70	0.77110460
67	STK24	0.76287788
68	MAP2K2	0.75660375
69	BCKDK	0.73687261
70	MAP3K12	0.72771739
71	PKN2	0.70910093
72	BRSK1	0.69649140
73	MAP3K11	0.68429419
74	STK4	0.68167290
75	CSNK2A1	0.67406519
76	MAP2K3	0.66391472
77	CSNK1E	0.64662010
78	BRAF	0.64407546
79	SYK	0.62632568
80	MST1R	0.62350084
81	MKNK2	0.60535210
82	KIT	0.58680404
83	ITK	0.57876783
84	CDK8	0.57815088
85	CHEK1	0.57606810
86	EIF2AK2	0.57158111
87	CDK6	0.56829573
88	PLK4	0.56629051
89	CDK3	0.55272640
90	IRAK4	0.54912273
91	PAK1	0.54857178
92	ARAF	0.54647693
93	TESK1	0.53956172
94	IRAK3	0.53714010
95	PIK3CG	0.53656996
96	CLK1	0.53367594
97	ABL2	0.53051487
98	CHEK2	0.52838431
99	LCK	0.51503334
100	TNIK	0.50336935
101	LYN	0.49709804
102	DAPK3	0.48808695
103	BMPR1B	0.48378841
104	PAK2	0.45228050
105	PDK2	0.44782216
106	MAPKAPK5	0.43550837
107	PRKCI	0.43063791
108	CDK1	0.40183365
109	CSF1R	0.40028428
110	ATM	0.40001825
111	JAK3	0.38409519
112	CDK2	0.36156584
113	INSRR	0.36005798
114	PLK3	0.35656291
115	CCNB1	0.34971196
116	ALK	0.34951629
117	RPS6KA6	0.34638147
118	MAPKAPK2	0.34500004
119	TGFBR2	0.33707996
120	DYRK1B	0.33049725
121	CDK11A	0.31712358
122	RPS6KC1	0.30968753
123	RPS6KL1	0.30968753
124	EPHB2	0.30224985
125	MAPK4	0.30016896
126	TBK1	0.28816939
127	DYRK2	0.28362588
128	WNK4	0.27869048
129	STK3	0.27531019
130	PRKDC	0.26742988
131	DMPK	0.23634883
132	MUSK	0.22880226
133	RPS6KA1	0.21095841
134	CDK9	0.18033397
135	AKT1	0.17858085
136	TYRO3	0.17344302
137	FGFR1	0.16940340

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Ribosome_Homo sapiens_hsa03010	8.46962498
2	DNA replication_Homo sapiens_hsa03030	3.71917851
3	Proteasome_Homo sapiens_hsa03050	3.27968310
4	RNA polymerase_Homo sapiens_hsa03020	3.19238907
5	Mismatch repair_Homo sapiens_hsa03430	3.14139657
6	Spliceosome_Homo sapiens_hsa03040	3.13895849
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.58073589
8	Homologous recombination_Homo sapiens_hsa03440	2.30221514
9	Nucleotide excision repair_Homo sapiens_hsa03420	2.28830225
10	Pyrimidine metabolism_Homo sapiens_hsa00240	2.23656108
11	RNA transport_Homo sapiens_hsa03013	2.10469741
12	Base excision repair_Homo sapiens_hsa03410	2.09387772
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.08449855
14	Parkinsons disease_Homo sapiens_hsa05012	1.98601506
15	Protein export_Homo sapiens_hsa03060	1.78511092
16	One carbon pool by folate_Homo sapiens_hsa00670	1.74611915
17	Huntingtons disease_Homo sapiens_hsa05016	1.59532642
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.51486557
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.50582976
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.50168945
21	RNA degradation_Homo sapiens_hsa03018	1.48691777
22	Cell cycle_Homo sapiens_hsa04110	1.38731778
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.38586645
24	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.34250851
25	Primary immunodeficiency_Homo sapiens_hsa05340	1.31184481
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.31107818
27	Basal transcription factors_Homo sapiens_hsa03022	1.30145019
28	Alzheimers disease_Homo sapiens_hsa05010	1.27998497
29	p53 signaling pathway_Homo sapiens_hsa04115	1.19890661
30	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.12506746
31	Antigen processing and presentation_Homo sapiens_hsa04612	1.05679533
32	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.01523180
33	Purine metabolism_Homo sapiens_hsa00230	1.00781616
34	mRNA surveillance pathway_Homo sapiens_hsa03015	0.93130943
35	Herpes simplex infection_Homo sapiens_hsa05168	0.85198455
36	Pyruvate metabolism_Homo sapiens_hsa00620	0.83110172
37	Sulfur relay system_Homo sapiens_hsa04122	0.82639957
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.80957317
39	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.77692320
40	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.71060356
41	Viral carcinogenesis_Homo sapiens_hsa05203	0.68219497
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.67570876
43	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.65003744
44	Folate biosynthesis_Homo sapiens_hsa00790	0.63452487
45	Glutathione metabolism_Homo sapiens_hsa00480	0.62425077
46	HTLV-I infection_Homo sapiens_hsa05166	0.62375109
47	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.62015902
48	Selenocompound metabolism_Homo sapiens_hsa00450	0.60213531
49	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.57764342
50	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.56220173
51	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.54824573
52	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.54694124
53	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.53745769
54	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.53651894
55	Thyroid cancer_Homo sapiens_hsa05216	0.51640720
56	Small cell lung cancer_Homo sapiens_hsa05222	0.51059181
57	Legionellosis_Homo sapiens_hsa05134	0.50369762
58	Measles_Homo sapiens_hsa05162	0.49948232
59	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.48913555
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.48248406
61	Alcoholism_Homo sapiens_hsa05034	0.47231493
62	Carbon metabolism_Homo sapiens_hsa01200	0.45875574
63	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.45793565
64	Basal cell carcinoma_Homo sapiens_hsa05217	0.45006984
65	Pentose phosphate pathway_Homo sapiens_hsa00030	0.44066465
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43793947
67	Apoptosis_Homo sapiens_hsa04210	0.42509468
68	Graft-versus-host disease_Homo sapiens_hsa05332	0.41293235
69	Propanoate metabolism_Homo sapiens_hsa00640	0.39172109
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.39135111
71	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.39004418
72	Fatty acid elongation_Homo sapiens_hsa00062	0.37930221
73	Asthma_Homo sapiens_hsa05310	0.37653397
74	Cardiac muscle contraction_Homo sapiens_hsa04260	0.37185178
75	Allograft rejection_Homo sapiens_hsa05330	0.37111135
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36885178
77	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33834566
78	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.33336615
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.32713191
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30987466
81	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.30911788
82	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.30811391
83	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.30570464
84	Acute myeloid leukemia_Homo sapiens_hsa05221	0.30459300
85	Notch signaling pathway_Homo sapiens_hsa04330	0.30067454
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29996936
87	Wnt signaling pathway_Homo sapiens_hsa04310	0.29103196
88	MicroRNAs in cancer_Homo sapiens_hsa05206	0.28876249
89	Leishmaniasis_Homo sapiens_hsa05140	0.28544102
90	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.28348003
91	Hepatitis B_Homo sapiens_hsa05161	0.27997337
92	Shigellosis_Homo sapiens_hsa05131	0.27897357
93	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.27657434
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.26400583
95	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.26320582
96	Pathways in cancer_Homo sapiens_hsa05200	0.26274309
97	Tyrosine metabolism_Homo sapiens_hsa00350	0.26272328
98	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.26046928
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.25960495
100	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.25821979
101	Bladder cancer_Homo sapiens_hsa05219	0.25497313
102	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.25060835
103	Metabolic pathways_Homo sapiens_hsa01100	0.23880585
104	Steroid biosynthesis_Homo sapiens_hsa00100	0.21073743
105	Other glycan degradation_Homo sapiens_hsa00511	0.19621333
106	Chemical carcinogenesis_Homo sapiens_hsa05204	0.19575112
107	Peroxisome_Homo sapiens_hsa04146	0.19541908
108	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.18533654
109	Toxoplasmosis_Homo sapiens_hsa05145	0.18153165
110	Collecting duct acid secretion_Homo sapiens_hsa04966	0.17351245
111	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.16942217
112	Renin-angiotensin system_Homo sapiens_hsa04614	0.16675494
113	Pertussis_Homo sapiens_hsa05133	0.16672879
114	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.15907631
115	Viral myocarditis_Homo sapiens_hsa05416	0.15872350
116	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.15704411
117	Influenza A_Homo sapiens_hsa05164	0.15133412
118	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.15021224
119	Linoleic acid metabolism_Homo sapiens_hsa00591	0.14529807
120	Colorectal cancer_Homo sapiens_hsa05210	0.13628100
121	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.13234313
122	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.12821475
123	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.12377302
124	Oocyte meiosis_Homo sapiens_hsa04114	0.11403843
125	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.11376517
126	Hippo signaling pathway_Homo sapiens_hsa04390	0.09522012
127	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.09339500
128	Nitrogen metabolism_Homo sapiens_hsa00910	0.06955842
129	Sulfur metabolism_Homo sapiens_hsa00920	0.06803607
130	Fat digestion and absorption_Homo sapiens_hsa04975	0.06770263
131	Galactose metabolism_Homo sapiens_hsa00052	0.05392820
132	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.04989609
133	Phototransduction_Homo sapiens_hsa04744	0.04947397
134	Regulation of autophagy_Homo sapiens_hsa04140	0.03017634
135	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.02006047
136	Arginine and proline metabolism_Homo sapiens_hsa00330	0.01998024
137	Retinol metabolism_Homo sapiens_hsa00830	0.01902673
138	Melanoma_Homo sapiens_hsa05218	0.01661617
139	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.00831820
140	Tryptophan metabolism_Homo sapiens_hsa00380	0.00346415
141	Caffeine metabolism_Homo sapiens_hsa00232	-0.0098522

RPL35A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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