RPL35AP15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)6.55929552
2maturation of SSU-rRNA (GO:0030490)6.34399129
3chaperone-mediated protein transport (GO:0072321)5.98125025
4DNA deamination (GO:0045006)5.72920958
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.29492098
6proteasome assembly (GO:0043248)4.89457325
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.57852911
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.35122403
9ATP synthesis coupled proton transport (GO:0015986)4.35122403
10negative regulation by host of viral transcription (GO:0043922)4.19867592
11behavioral response to nicotine (GO:0035095)4.15521224
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.05308228
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.03633906
14NADH dehydrogenase complex assembly (GO:0010257)4.03633906
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.03633906
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.02451223
17peptidyl-histidine modification (GO:0018202)3.91431850
18positive regulation of protein homooligomerization (GO:0032464)3.89642462
19protein targeting to mitochondrion (GO:0006626)3.89091288
20water-soluble vitamin biosynthetic process (GO:0042364)3.89068773
21cytidine deamination (GO:0009972)3.83779861
22cytidine metabolic process (GO:0046087)3.83779861
23cytidine catabolic process (GO:0006216)3.83779861
24ribosomal small subunit biogenesis (GO:0042274)3.76256021
25neuromuscular process controlling posture (GO:0050884)3.75742538
26deoxyribose phosphate biosynthetic process (GO:0046385)3.72526910
272-deoxyribonucleotide biosynthetic process (GO:0009265)3.72526910
28protein complex biogenesis (GO:0070271)3.65712597
29establishment of protein localization to mitochondrion (GO:0072655)3.64821003
30protein-cofactor linkage (GO:0018065)3.62858142
31viral transcription (GO:0019083)3.62608755
32translational termination (GO:0006415)3.57806668
33maturation of 5.8S rRNA (GO:0000460)3.57635977
34negative regulation of oligodendrocyte differentiation (GO:0048715)3.57430254
35ribosomal large subunit biogenesis (GO:0042273)3.52725898
36protein localization to mitochondrion (GO:0070585)3.50435706
37pseudouridine synthesis (GO:0001522)3.49229106
38ear development (GO:0043583)3.48629426
39pyrimidine ribonucleoside catabolic process (GO:0046133)3.44371585
40mitochondrial respiratory chain complex assembly (GO:0033108)3.38476573
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.32735124
42protein localization to cilium (GO:0061512)3.31554942
43cotranslational protein targeting to membrane (GO:0006613)3.30097170
44negative regulation of T cell differentiation in thymus (GO:0033085)3.29833928
45protein targeting to ER (GO:0045047)3.28792562
46histone mRNA metabolic process (GO:0008334)3.26164371
47negative regulation of telomere maintenance (GO:0032205)3.24716483
48termination of RNA polymerase III transcription (GO:0006386)3.21377365
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.21377365
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21088441
51translational elongation (GO:0006414)3.20705369
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19394497
53cellular component biogenesis (GO:0044085)3.18892422
54muscle organ morphogenesis (GO:0048644)3.15544886
55histone H2A acetylation (GO:0043968)3.15322758
56establishment of protein localization to endoplasmic reticulum (GO:0072599)3.15060089
57ribonucleoprotein complex biogenesis (GO:0022613)3.11375995
58protein localization to endoplasmic reticulum (GO:0070972)3.09487141
59electron transport chain (GO:0022900)3.08950544
60positive regulation of T cell apoptotic process (GO:0070234)3.07682116
61translation (GO:0006412)3.07618647
627-methylguanosine mRNA capping (GO:0006370)3.05936719
63respiratory electron transport chain (GO:0022904)3.04560841
64nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.03177968
65preassembly of GPI anchor in ER membrane (GO:0016254)3.00818658
66spliceosomal snRNP assembly (GO:0000387)3.00005713
67RNA capping (GO:0036260)2.98413626
687-methylguanosine RNA capping (GO:0009452)2.98413626
69melanosome localization (GO:0032400)2.90863519
70rRNA catabolic process (GO:0016075)2.90795418
71positive regulation of macrophage differentiation (GO:0045651)2.87698294
72transcription elongation from RNA polymerase II promoter (GO:0006368)2.85663899
73ribosome assembly (GO:0042255)2.83876858
74GPI anchor metabolic process (GO:0006505)2.83615015
75organelle disassembly (GO:1903008)2.82625909
76translational initiation (GO:0006413)2.82336371
77ribonucleoprotein complex disassembly (GO:0032988)2.81306368
78polarized epithelial cell differentiation (GO:0030859)2.80334358
79protein K11-linked ubiquitination (GO:0070979)2.80060598
80cullin deneddylation (GO:0010388)2.79874826
81intracellular protein transmembrane import (GO:0044743)2.79150347
82ribosome biogenesis (GO:0042254)2.78953850
83isotype switching (GO:0045190)2.78190015
84somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.78190015
85somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.78190015
86detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.78064575
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77967738
88pigment granule localization (GO:0051875)2.77024220
89rRNA processing (GO:0006364)2.73789304
90rRNA metabolic process (GO:0016072)2.72994140
91positive regulation of protein oligomerization (GO:0032461)2.71360813
92regulation of isotype switching to IgG isotypes (GO:0048302)2.71312832
93cellular protein complex disassembly (GO:0043624)2.70823409
94interferon-gamma production (GO:0032609)2.69933705
95regulation of catecholamine metabolic process (GO:0042069)2.69157652
96regulation of dopamine metabolic process (GO:0042053)2.69157652
97regulation of nuclear cell cycle DNA replication (GO:0033262)2.68588711
98kinetochore assembly (GO:0051382)2.68145957
99tRNA processing (GO:0008033)2.65743752
100base-excision repair, AP site formation (GO:0006285)2.65400505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.20085998
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.35669909
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.84048703
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.51545975
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42790181
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.36883601
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.05742125
8VDR_22108803_ChIP-Seq_LS180_Human2.83768994
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.82249485
10VDR_23849224_ChIP-Seq_CD4+_Human2.80239084
11FOXP3_21729870_ChIP-Seq_TREG_Human2.66904417
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.49241034
13MYC_18940864_ChIP-ChIP_HL60_Human2.45166970
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44046089
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.39690841
16IRF1_19129219_ChIP-ChIP_H3396_Human2.39451732
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.30901836
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30804822
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.23639144
20RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10139328
21ZNF274_21170338_ChIP-Seq_K562_Hela2.05285345
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02542821
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.94810933
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.91097854
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90165034
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88868848
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88501061
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85723475
29ELK1_19687146_ChIP-ChIP_HELA_Human1.85514074
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.83562089
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.83247278
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.83089060
33POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.77937328
34GABP_19822575_ChIP-Seq_HepG2_Human1.77078629
35IGF1R_20145208_ChIP-Seq_DFB_Human1.65360324
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59275991
37XRN2_22483619_ChIP-Seq_HELA_Human1.58565349
38TTF2_22483619_ChIP-Seq_HELA_Human1.55421940
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50524943
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45546100
41TP53_22573176_ChIP-Seq_HFKS_Human1.44692541
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42108326
43FUS_26573619_Chip-Seq_HEK293_Human1.37783395
44PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.35935233
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35199517
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34959468
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32447839
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31758410
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.23959736
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21608104
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21102818
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16555561
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16391271
54SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14825902
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.14678034
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13831426
57EWS_26573619_Chip-Seq_HEK293_Human1.11983379
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09159225
59FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08163330
60DCP1A_22483619_ChIP-Seq_HELA_Human1.07790221
61NANOG_20526341_ChIP-Seq_ESCs_Human1.07544875
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06887371
63ER_23166858_ChIP-Seq_MCF-7_Human1.05840106
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05290731
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05071093
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04643121
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03285398
68AR_20517297_ChIP-Seq_VCAP_Human1.00174175
69ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99751035
70ERA_21632823_ChIP-Seq_H3396_Human0.98690684
71PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97376195
72CBX2_27304074_Chip-Seq_ESCs_Mouse0.97201965
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96602815
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95031806
75EZH2_27294783_Chip-Seq_NPCs_Mouse0.94873874
76MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93624608
77NCOR_22424771_ChIP-Seq_293T_Human0.92883880
78YY1_22570637_ChIP-Seq_MALME-3M_Human0.92644132
79KDM5A_27292631_Chip-Seq_BREAST_Human0.91670240
80GATA3_26560356_Chip-Seq_TH2_Human0.90698471
81ELK1_22589737_ChIP-Seq_MCF10A_Human0.90513863
82CTCF_20526341_ChIP-Seq_ESCs_Human0.89773547
83CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87457124
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86570819
85GATA3_21878914_ChIP-Seq_MCF-7_Human0.86446062
86TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85982012
87P53_21459846_ChIP-Seq_SAOS-2_Human0.85587591
88RBPJ_21746931_ChIP-Seq_IB4_Human0.85391059
89BCL6_27268052_Chip-Seq_Bcells_Human0.83025710
90CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82928326
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82695040
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.82378420
93NELFA_20434984_ChIP-Seq_ESCs_Mouse0.81222415
94HTT_18923047_ChIP-ChIP_STHdh_Human0.81142373
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80089524
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79438646
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77883323
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76888108
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.75832635
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75241921

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction3.20101393
2MP0005075_abnormal_melanosome_morpholog2.92476433
3MP0000372_irregular_coat_pigmentation2.90990847
4MP0003941_abnormal_skin_development2.70869462
5MP0006072_abnormal_retinal_apoptosis2.66285312
6MP0006292_abnormal_olfactory_placode2.66120107
7MP0003195_calcinosis2.40153946
8MP0002938_white_spotting2.39520002
9MP0008995_early_reproductive_senescence2.37437289
10MP0009379_abnormal_foot_pigmentation2.35718302
11MP0003122_maternal_imprinting2.23132487
12MP0004742_abnormal_vestibular_system2.17369277
13MP0004145_abnormal_muscle_electrophysio2.16006387
14MP0005646_abnormal_pituitary_gland2.00993972
15MP0005387_immune_system_phenotype1.99192586
16MP0001790_abnormal_immune_system1.99192586
17MP0002138_abnormal_hepatobiliary_system1.91018028
18MP0005408_hypopigmentation1.77966082
19MP0002163_abnormal_gland_morphology1.75556392
20MP0003121_genomic_imprinting1.75095083
21MP0003806_abnormal_nucleotide_metabolis1.75062520
22MP0002653_abnormal_ependyma_morphology1.73226099
23MP0005671_abnormal_response_to1.72773049
24MP0001485_abnormal_pinna_reflex1.67898326
25MP0003646_muscle_fatigue1.66863061
26MP0002277_abnormal_respiratory_mucosa1.63938903
27MP0002234_abnormal_pharynx_morphology1.62333387
28MP0009046_muscle_twitch1.61503494
29MP0008789_abnormal_olfactory_epithelium1.60944053
30MP0005084_abnormal_gallbladder_morpholo1.60521660
31MP0002148_abnormal_hypersensitivity_rea1.52869541
32MP0001501_abnormal_sleep_pattern1.52678102
33MP0005174_abnormal_tail_pigmentation1.46588354
34MP0001188_hyperpigmentation1.41560179
35MP0005253_abnormal_eye_physiology1.40699056
36MP0001986_abnormal_taste_sensitivity1.37464082
37MP0000049_abnormal_middle_ear1.37205993
38MP0009764_decreased_sensitivity_to1.35397704
39MP0004142_abnormal_muscle_tone1.33752778
40MP0003786_premature_aging1.33059858
41MP0009697_abnormal_copulation1.32811727
42MP0006276_abnormal_autonomic_nervous1.31697702
43MP0008058_abnormal_DNA_repair1.27283176
44MP0005389_reproductive_system_phenotype1.24348670
45MP0001873_stomach_inflammation1.20862062
46MP0001835_abnormal_antigen_presentation1.20680998
47MP0002160_abnormal_reproductive_system1.20057557
48MP0000685_abnormal_immune_system1.18955016
49MP0003186_abnormal_redox_activity1.16403135
50MP0005394_taste/olfaction_phenotype1.14430050
51MP0005499_abnormal_olfactory_system1.14430050
52MP0002102_abnormal_ear_morphology1.13092576
53MP0009765_abnormal_xenobiotic_induced1.12029317
54MP0008007_abnormal_cellular_replicative1.11991943
55MP0005423_abnormal_somatic_nervous1.11152982
56MP0000631_abnormal_neuroendocrine_gland1.09225082
57MP0003718_maternal_effect1.08968160
58MP0003693_abnormal_embryo_hatching1.08866156
59MP0001293_anophthalmia1.08606485
60MP0001905_abnormal_dopamine_level1.06370901
61MP0001919_abnormal_reproductive_system1.05870673
62MP0002735_abnormal_chemical_nociception1.04152011
63MP0000569_abnormal_digit_pigmentation1.02936932
64MP0003787_abnormal_imprinting1.02693138
65MP0005551_abnormal_eye_electrophysiolog1.01602211
66MP0004147_increased_porphyrin_level0.99524048
67MP0008875_abnormal_xenobiotic_pharmacok0.95358525
68MP0000371_diluted_coat_color0.95090054
69MP0008872_abnormal_physiological_respon0.95005134
70MP0009745_abnormal_behavioral_response0.94351200
71MP0002095_abnormal_skin_pigmentation0.93695136
72MP0005195_abnormal_posterior_eye0.90254246
73MP0000604_amyloidosis0.89816391
74MP0004957_abnormal_blastocyst_morpholog0.89120592
75MP0001800_abnormal_humoral_immune0.87387955
76MP0001963_abnormal_hearing_physiology0.86681232
77MP0005167_abnormal_blood-brain_barrier0.83854164
78MP0002132_abnormal_respiratory_system0.82530121
79MP0004043_abnormal_pH_regulation0.81324862
80MP0001502_abnormal_circadian_rhythm0.78812469
81MP0010386_abnormal_urinary_bladder0.78180177
82MP0006035_abnormal_mitochondrial_morpho0.78088238
83MP0003763_abnormal_thymus_physiology0.77841539
84MP0002177_abnormal_outer_ear0.77474981
85MP0004885_abnormal_endolymph0.77432498
86MP0001270_distended_abdomen0.77284951
87MP0001881_abnormal_mammary_gland0.76800321
88MP0002557_abnormal_social/conspecific_i0.76270879
89MP0003329_amyloid_beta_deposits0.74762355
90MP0002067_abnormal_sensory_capabilities0.73023807
91MP0008873_increased_physiological_sensi0.71731131
92MP0005410_abnormal_fertilization0.71684083
93MP0005379_endocrine/exocrine_gland_phen0.71398347
94MP0005464_abnormal_platelet_physiology0.71144614
95MP0003137_abnormal_impulse_conducting0.70972223
96MP0002572_abnormal_emotion/affect_behav0.69680774
97MP0008877_abnormal_DNA_methylation0.69468962
98MP0002638_abnormal_pupillary_reflex0.69117206
99MP0001764_abnormal_homeostasis0.68966234
100MP0002272_abnormal_nervous_system0.67119402

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.57328158
2Acute encephalopathy (HP:0006846)4.31698296
3Abnormal mitochondria in muscle tissue (HP:0008316)4.07152324
4Abnormality of alanine metabolism (HP:0010916)3.87350696
5Hyperalaninemia (HP:0003348)3.87350696
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.87350696
7Mitochondrial inheritance (HP:0001427)3.87297038
8Increased CSF lactate (HP:0002490)3.77961288
9Increased hepatocellular lipid droplets (HP:0006565)3.58745701
10Progressive macrocephaly (HP:0004481)3.51461400
11Nephronophthisis (HP:0000090)3.30776629
12Abnormality of midbrain morphology (HP:0002418)3.25615849
13Molar tooth sign on MRI (HP:0002419)3.25615849
14Colon cancer (HP:0003003)3.19945103
15Increased serum lactate (HP:0002151)3.14160124
16Medial flaring of the eyebrow (HP:0010747)3.12508776
17Lipid accumulation in hepatocytes (HP:0006561)3.11288946
18Attenuation of retinal blood vessels (HP:0007843)3.03092552
19Degeneration of anterior horn cells (HP:0002398)2.93333850
20Abnormality of the anterior horn cell (HP:0006802)2.93333850
21Hyperglycinemia (HP:0002154)2.93179878
22Optic disc pallor (HP:0000543)2.92812583
23Pancreatic fibrosis (HP:0100732)2.90684663
24Pancreatic cysts (HP:0001737)2.90066036
25Abnormal pupillary function (HP:0007686)2.85776331
26Nephrogenic diabetes insipidus (HP:0009806)2.83032555
27Lactic acidosis (HP:0003128)2.81308805
28Abnormality of the renal cortex (HP:0011035)2.78184642
29Reticulocytopenia (HP:0001896)2.75496891
30Stomatitis (HP:0010280)2.72311345
31Abnormality of the renal medulla (HP:0100957)2.72113443
323-Methylglutaconic aciduria (HP:0003535)2.71480588
33Pendular nystagmus (HP:0012043)2.69934051
34Abolished electroretinogram (ERG) (HP:0000550)2.69246022
35Cerebral edema (HP:0002181)2.65459628
36Increased intramyocellular lipid droplets (HP:0012240)2.63843592
37Focal motor seizures (HP:0011153)2.55716443
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53916121
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53916121
40Congenital, generalized hypertrichosis (HP:0004540)2.53566044
41IgG deficiency (HP:0004315)2.51427326
42Gastrointestinal infarctions (HP:0005244)2.47125395
43Congenital primary aphakia (HP:0007707)2.44430137
44Gait imbalance (HP:0002141)2.41286938
45Adrenal hypoplasia (HP:0000835)2.40868388
46Hepatocellular necrosis (HP:0001404)2.38410806
47Hyperglycinuria (HP:0003108)2.32340404
48Parakeratosis (HP:0001036)2.27687019
49Bony spicule pigmentary retinopathy (HP:0007737)2.26883828
50Tachypnea (HP:0002789)2.25699473
51Respiratory failure (HP:0002878)2.25438069
52Microretrognathia (HP:0000308)2.23222162
53Abnormality of serum amino acid levels (HP:0003112)2.18853853
54Macrocytic anemia (HP:0001972)2.16574845
55Tubular atrophy (HP:0000092)2.14253632
56Abnormality of cells of the erythroid lineage (HP:0012130)2.14209966
57Absent thumb (HP:0009777)2.13726953
58Abnormal number of incisors (HP:0011064)2.13422911
59Methylmalonic aciduria (HP:0012120)2.13157638
60Exertional dyspnea (HP:0002875)2.12665023
61Decreased central vision (HP:0007663)2.11724824
62Methylmalonic acidemia (HP:0002912)2.11533162
63Abnormality of glycine metabolism (HP:0010895)2.10963769
64Abnormality of serine family amino acid metabolism (HP:0010894)2.10963769
65True hermaphroditism (HP:0010459)2.07600278
66Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07522152
67Stenosis of the external auditory canal (HP:0000402)2.04743762
68Abnormal delayed hypersensitivity skin test (HP:0002963)2.00304630
69Increased muscle lipid content (HP:0009058)2.00247217
70Panhypogammaglobulinemia (HP:0003139)1.99166684
71Abnormality of the labia minora (HP:0012880)1.95574063
72Broad-based gait (HP:0002136)1.93453942
73Cystic liver disease (HP:0006706)1.92988654
74Lethargy (HP:0001254)1.91060211
75Renal Fanconi syndrome (HP:0001994)1.90657031
76Hepatic necrosis (HP:0002605)1.90399522
77Agitation (HP:0000713)1.89420634
78Renal cortical cysts (HP:0000803)1.88410671
79Submucous cleft hard palate (HP:0000176)1.88322072
80Exercise intolerance (HP:0003546)1.87941090
81Polydipsia (HP:0001959)1.87705149
82Abnormal drinking behavior (HP:0030082)1.87705149
83Blindness (HP:0000618)1.86400136
84Abnormality of T cell physiology (HP:0011840)1.85115750
85Congenital stationary night blindness (HP:0007642)1.84594292
86Hypoplastic pelvis (HP:0008839)1.83875893
87Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83739760
88Type II lissencephaly (HP:0007260)1.83077718
89Spinal muscular atrophy (HP:0007269)1.82593881
90Increased IgM level (HP:0003496)1.82564785
91Progressive microcephaly (HP:0000253)1.82374699
92CNS demyelination (HP:0007305)1.80540905
93Congenital hepatic fibrosis (HP:0002612)1.78439326
94Visual hallucinations (HP:0002367)1.77167773
95Lissencephaly (HP:0001339)1.73713752
96Atrophy/Degeneration involving motor neurons (HP:0007373)1.73588201
97Hemiplegia (HP:0002301)1.73239702
98Aplasia/hypoplasia of the uterus (HP:0008684)1.72904792
99Chronic hepatic failure (HP:0100626)1.71809618
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.70817455

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK36.78650094
2MAP4K23.86751594
3BUB13.27434171
4TSSK63.01416413
5EIF2AK12.63821605
6SRPK12.62246213
7TXK2.32870179
8PASK2.27696896
9ADRBK22.22872004
10NEK12.03396655
11BMPR1B1.87632761
12TNK21.87120265
13CDK191.85789253
14ZAK1.68521352
15CSNK1G31.67769496
16NUAK11.54802480
17EIF2AK31.50642767
18PIK3CA1.44641357
19STK241.42335273
20CDK81.41430038
21KDR1.40266994
22ITK1.38547862
23CSNK1G11.37365768
24CSNK1A1L1.32641451
25CSNK1G21.31755221
26MAP4K11.30726130
27TAF11.29910602
28GRK11.28340107
29OXSR11.26405261
30DYRK21.23368302
31PDK21.20962108
32TLK11.17981062
33MAP2K71.16768226
34WNK41.11201007
35FGFR10.99803803
36IKBKB0.99771463
37VRK20.98388265
38STK38L0.95891109
39TBK10.93887424
40FES0.92762706
41VRK10.84223779
42PRKD30.82939886
43CCNB10.82267510
44PAK30.82192506
45STK390.81657882
46TIE10.81218824
47SIK30.81062495
48AURKA0.79945078
49PRKCQ0.79577953
50PRKCH0.78754849
51BCKDK0.78463961
52ALK0.77194060
53ADRBK10.72713130
54PINK10.69878873
55TGFBR10.69399354
56MAP3K120.69179812
57MAP3K110.67299699
58TESK20.65574257
59INSRR0.63748965
60BCR0.63689522
61PLK30.62489230
62ATR0.59587955
63LRRK20.56661678
64CSNK1A10.56559731
65ERBB30.56203819
66AKT30.55793531
67SIK20.55313097
68MKNK10.54094533
69KIT0.53996783
70CDC70.53732790
71TEC0.53727408
72CAMKK10.53029780
73IRAK30.51521356
74EIF2AK20.49993500
75IKBKE0.49844867
76PHKG20.48577390
77PHKG10.48577390
78LIMK10.48271785
79CSNK2A10.47680197
80SYK0.46893516
81WNK30.44919230
82CSNK2A20.44650235
83NME10.43443912
84LCK0.43048553
85OBSCN0.42547485
86RPS6KA50.42364098
87PRKCA0.40912306
88PTK2B0.40844265
89PLK40.38947698
90PRKACA0.38840843
91AURKB0.37546740
92CAMK2A0.36080994
93CHUK0.35991550
94PRKCE0.35189222
95PRKCZ0.34993491
96DAPK10.34533528
97PRKCG0.34226709
98PLK20.33214950
99STK100.32568747
100PLK10.29714854

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.72384626
2Oxidative phosphorylation_Homo sapiens_hsa001903.34010222
3Basal transcription factors_Homo sapiens_hsa030223.10513566
4Parkinsons disease_Homo sapiens_hsa050123.07109549
5Proteasome_Homo sapiens_hsa030502.91849894
6Protein export_Homo sapiens_hsa030602.76953043
7RNA polymerase_Homo sapiens_hsa030202.74293701
8Sulfur metabolism_Homo sapiens_hsa009202.34441357
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25360537
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18873576
11Vitamin B6 metabolism_Homo sapiens_hsa007502.18871216
12Huntingtons disease_Homo sapiens_hsa050162.15452332
13Alzheimers disease_Homo sapiens_hsa050102.09027742
14Phototransduction_Homo sapiens_hsa047441.92153030
15RNA degradation_Homo sapiens_hsa030181.90014818
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79291557
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.73285917
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73224549
19Sulfur relay system_Homo sapiens_hsa041221.67304716
20Primary immunodeficiency_Homo sapiens_hsa053401.64837121
21Caffeine metabolism_Homo sapiens_hsa002321.63341117
22Spliceosome_Homo sapiens_hsa030401.63304610
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49916702
24Allograft rejection_Homo sapiens_hsa053301.46892511
25One carbon pool by folate_Homo sapiens_hsa006701.46830068
26Nucleotide excision repair_Homo sapiens_hsa034201.43938080
27Pyrimidine metabolism_Homo sapiens_hsa002401.42999838
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38800656
29Selenocompound metabolism_Homo sapiens_hsa004501.38666023
30Asthma_Homo sapiens_hsa053101.29077931
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28054812
32Antigen processing and presentation_Homo sapiens_hsa046121.25824428
33Autoimmune thyroid disease_Homo sapiens_hsa053201.25637383
34RNA transport_Homo sapiens_hsa030131.25434631
35Graft-versus-host disease_Homo sapiens_hsa053321.21414259
36Cardiac muscle contraction_Homo sapiens_hsa042601.16012191
37Type I diabetes mellitus_Homo sapiens_hsa049401.13530611
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08214505
39DNA replication_Homo sapiens_hsa030301.07428553
40Linoleic acid metabolism_Homo sapiens_hsa005911.04932648
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03204008
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.00930955
43Rheumatoid arthritis_Homo sapiens_hsa053230.96546787
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96052436
45Peroxisome_Homo sapiens_hsa041460.94246755
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93859265
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93327611
48Base excision repair_Homo sapiens_hsa034100.93200312
49Propanoate metabolism_Homo sapiens_hsa006400.91489067
50Purine metabolism_Homo sapiens_hsa002300.88499026
51Pentose phosphate pathway_Homo sapiens_hsa000300.86523748
52p53 signaling pathway_Homo sapiens_hsa041150.80751265
53Butanoate metabolism_Homo sapiens_hsa006500.79661057
54Arachidonic acid metabolism_Homo sapiens_hsa005900.78775460
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77396689
56Steroid biosynthesis_Homo sapiens_hsa001000.74071261
57Collecting duct acid secretion_Homo sapiens_hsa049660.73749108
58Pyruvate metabolism_Homo sapiens_hsa006200.72577845
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72575254
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72184017
61Homologous recombination_Homo sapiens_hsa034400.71852620
62Hematopoietic cell lineage_Homo sapiens_hsa046400.70704608
63Mismatch repair_Homo sapiens_hsa034300.68530163
64Biosynthesis of amino acids_Homo sapiens_hsa012300.68166605
65Nicotine addiction_Homo sapiens_hsa050330.66890603
66Olfactory transduction_Homo sapiens_hsa047400.65032946
67Metabolic pathways_Homo sapiens_hsa011000.63604676
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62288666
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59484310
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.59317055
71Regulation of autophagy_Homo sapiens_hsa041400.58506966
72Fanconi anemia pathway_Homo sapiens_hsa034600.58421148
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58201282
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54858861
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53672861
76Tryptophan metabolism_Homo sapiens_hsa003800.53590044
77Chemical carcinogenesis_Homo sapiens_hsa052040.51376989
78Measles_Homo sapiens_hsa051620.50465887
79Fat digestion and absorption_Homo sapiens_hsa049750.47262364
80Arginine and proline metabolism_Homo sapiens_hsa003300.47084078
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46749754
82Nitrogen metabolism_Homo sapiens_hsa009100.46052110
83Ether lipid metabolism_Homo sapiens_hsa005650.44719626
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43748312
85Carbon metabolism_Homo sapiens_hsa012000.43271816
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41632795
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40476134
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40073489
89Non-homologous end-joining_Homo sapiens_hsa034500.37310452
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.35326287
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.34848350
92Viral myocarditis_Homo sapiens_hsa054160.33971108
93Systemic lupus erythematosus_Homo sapiens_hsa053220.31884870
94Herpes simplex infection_Homo sapiens_hsa051680.27834395
95beta-Alanine metabolism_Homo sapiens_hsa004100.26577856
96Retinol metabolism_Homo sapiens_hsa008300.26002341
97T cell receptor signaling pathway_Homo sapiens_hsa046600.25425063
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24250983
99Ovarian steroidogenesis_Homo sapiens_hsa049130.24244493
100Salmonella infection_Homo sapiens_hsa051320.24153637

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