ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	6.84736355
2	translational termination (GO:0006415)	6.59961411
3	behavioral response to nicotine (GO:0035095)	6.37753709
4	ribosomal small subunit assembly (GO:0000028)	5.86043936
5	translational elongation (GO:0006414)	5.65357637
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.62424837
7	cotranslational protein targeting to membrane (GO:0006613)	5.61692911
8	protein targeting to ER (GO:0045047)	5.56718818
9	maturation of SSU-rRNA (GO:0030490)	5.45150424
10	protein neddylation (GO:0045116)	5.36777725
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.35549263
12	protein localization to endoplasmic reticulum (GO:0070972)	5.26875736
13	ribosomal small subunit biogenesis (GO:0042274)	5.23696440
14	cellular protein complex disassembly (GO:0043624)	5.00906648
15	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.88923785
16	viral life cycle (GO:0019058)	4.73263434
17	ribosomal large subunit biogenesis (GO:0042273)	4.40832523
18	protein complex disassembly (GO:0043241)	4.25712702
19	translational initiation (GO:0006413)	4.08005487
20	macromolecular complex disassembly (GO:0032984)	4.05103522
21	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.02642152
22	ATP synthesis coupled proton transport (GO:0015986)	4.02642152
23	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.88390028
24	glycerophospholipid catabolic process (GO:0046475)	3.79020138
25	cellular response to interferon-beta (GO:0035458)	3.74677847
26	chaperone-mediated protein transport (GO:0072321)	3.73334417
27	interferon-gamma production (GO:0032609)	3.71007220
28	protein targeting to membrane (GO:0006612)	3.63794177
29	translation (GO:0006412)	3.45099424
30	inner mitochondrial membrane organization (GO:0007007)	3.44096470
31	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.41960890
32	termination of RNA polymerase III transcription (GO:0006386)	3.40983216
33	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.40983216
34	endoderm formation (GO:0001706)	3.37044433
35	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.29878546
36	NADH dehydrogenase complex assembly (GO:0010257)	3.29878546
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.29878546
38	nonmotile primary cilium assembly (GO:0035058)	3.27951169
39	parturition (GO:0007567)	3.25686560
40	mRNA catabolic process (GO:0006402)	3.24644281
41	positive regulation of protein homooligomerization (GO:0032464)	3.24579533
42	response to redox state (GO:0051775)	3.22857480
43	artery smooth muscle contraction (GO:0014824)	3.20473802
44	axoneme assembly (GO:0035082)	3.19305651
45	DNA double-strand break processing (GO:0000729)	3.13322753
46	protein complex biogenesis (GO:0070271)	3.11924914
47	positive regulation of growth hormone secretion (GO:0060124)	3.07683645
48	tongue development (GO:0043586)	3.07499088
49	genetic imprinting (GO:0071514)	3.04282463
50	dentate gyrus development (GO:0021542)	3.02921873
51	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.02373961
52	spinal cord association neuron differentiation (GO:0021527)	3.02294775
53	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.99958295
54	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.99958295
55	rRNA catabolic process (GO:0016075)	2.98655204
56	telencephalon development (GO:0021537)	2.98643950
57	cell proliferation in forebrain (GO:0021846)	2.98449957
58	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.96798846
59	mitochondrial respiratory chain complex assembly (GO:0033108)	2.93066738
60	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.91203582
61	pseudouridine synthesis (GO:0001522)	2.89556365
62	ribonucleoprotein complex biogenesis (GO:0022613)	2.88154674
63	cellular component biogenesis (GO:0044085)	2.87668470
64	urate metabolic process (GO:0046415)	2.86844064
65	RNA catabolic process (GO:0006401)	2.84884262
66	protein localization to cilium (GO:0061512)	2.81262547
67	positive regulation of T cell apoptotic process (GO:0070234)	2.79785721
68	pyrimidine nucleobase catabolic process (GO:0006208)	2.78756155
69	protein K6-linked ubiquitination (GO:0085020)	2.72927207
70	water-soluble vitamin biosynthetic process (GO:0042364)	2.71396322
71	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.71135646
72	mitochondrion transport along microtubule (GO:0047497)	2.70167403
73	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.70167403
74	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.69683858
75	dendritic spine morphogenesis (GO:0060997)	2.69182642
76	forebrain morphogenesis (GO:0048853)	2.66361185
77	somite development (GO:0061053)	2.65885251
78	tonic smooth muscle contraction (GO:0014820)	2.64916333
79	serotonin receptor signaling pathway (GO:0007210)	2.64077051
80	prenylation (GO:0097354)	2.62869012
81	protein prenylation (GO:0018342)	2.62869012
82	axon ensheathment in central nervous system (GO:0032291)	2.62345662
83	central nervous system myelination (GO:0022010)	2.62345662
84	rRNA metabolic process (GO:0016072)	2.59484912
85	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.59428842
86	GPI anchor metabolic process (GO:0006505)	2.59021752
87	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.58752084
88	negative regulation of appetite (GO:0032099)	2.58429598
89	negative regulation of response to food (GO:0032096)	2.58429598
90	axonal fasciculation (GO:0007413)	2.58265687
91	negative regulation of telomere maintenance (GO:0032205)	2.57507873
92	rRNA processing (GO:0006364)	2.56959430
93	establishment of protein localization to membrane (GO:0090150)	2.54904539
94	protein homotrimerization (GO:0070207)	2.54861979
95	establishment of mitochondrion localization (GO:0051654)	2.54240008
96	kidney morphogenesis (GO:0060993)	2.53157559
97	cerebellar Purkinje cell differentiation (GO:0021702)	2.52582004
98	GMP metabolic process (GO:0046037)	2.51445564
99	replication fork processing (GO:0031297)	2.50988439
100	regulation of telomerase activity (GO:0051972)	2.50610961

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.95122924
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.68652800
3	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.55757894
4	VDR_22108803_ChIP-Seq_LS180_Human	2.48354090
5	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.31950938
6	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.30021037
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.26715349
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.18706638
9	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.14292392
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.05747413
11	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	2.03833894
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.01776789
13	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.99131423
14	EWS_26573619_Chip-Seq_HEK293_Human	1.98325242
15	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.97193419
16	GBX2_23144817_ChIP-Seq_PC3_Human	1.92950084
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.81825641
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.79208421
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.74976394
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.72206825
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.69510391
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.69332600
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.67627378
24	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.67268707
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66860111
26	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.66346735
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.63281003
28	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.59469510
29	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.58652404
30	FUS_26573619_Chip-Seq_HEK293_Human	1.55502414
31	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.55060879
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.51246767
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.50063955
34	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.44495818
35	REST_21632747_ChIP-Seq_MESCs_Mouse	1.43669657
36	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.42615145
37	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.40346907
38	P300_19829295_ChIP-Seq_ESCs_Human	1.38669322
39	NCOR_22424771_ChIP-Seq_293T_Human	1.38652145
40	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.35691890
41	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33567359
42	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.33194461
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32958758
44	NANOG_20526341_ChIP-Seq_ESCs_Human	1.32863286
45	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.31222675
46	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.30672321
47	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.27726693
48	VDR_23849224_ChIP-Seq_CD4+_Human	1.26647680
49	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.24242403
50	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.24045061
51	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.24038972
52	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23637497
53	ELK1_19687146_ChIP-ChIP_HELA_Human	1.22253838
54	TTF2_22483619_ChIP-Seq_HELA_Human	1.22249103
55	IGF1R_20145208_ChIP-Seq_DFB_Human	1.21964178
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.21787914
57	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.20903671
58	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20112652
59	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.19850162
60	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.19685541
61	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.19300167
62	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.18925006
63	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.16904810
64	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.15520027
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14942609
66	IRF1_19129219_ChIP-ChIP_H3396_Human	1.12478325
67	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.12111240
68	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.11212285
69	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.09813701
70	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07897115
71	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.07472400
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.07041597
73	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.05240533
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04631497
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04631497
76	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.03962189
77	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.03893669
78	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.03018968
79	FOXP3_21729870_ChIP-Seq_TREG_Human	1.02535661
80	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.02471486
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.02388388
82	AR_20517297_ChIP-Seq_VCAP_Human	1.02140895
83	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01262103
84	TAF2_19829295_ChIP-Seq_ESCs_Human	1.01177676
85	RNF2_27304074_Chip-Seq_NSC_Mouse	0.99164884
86	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.98807295
87	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.98377007
88	ERA_21632823_ChIP-Seq_H3396_Human	0.98192103
89	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97934474
90	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.97853728
91	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.97853728
92	OCT4_20526341_ChIP-Seq_ESCs_Human	0.95430981
93	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.95306190
94	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.94358230
95	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.93504640
96	CBP_20019798_ChIP-Seq_JUKART_Human	0.93440028
97	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.93440028
98	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.93366958
99	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.92801560
100	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.92571032

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.78098874
2	MP0003787_abnormal_imprinting	3.61878133
3	MP0008877_abnormal_DNA_methylation	3.56194447
4	MP0004142_abnormal_muscle_tone	2.91458309
5	MP0003122_maternal_imprinting	2.70909769
6	MP0002653_abnormal_ependyma_morphology	2.56839375
7	MP0002163_abnormal_gland_morphology	2.28162875
8	MP0003646_muscle_fatigue	2.27988385
9	MP0001485_abnormal_pinna_reflex	2.18449029
10	MP0003123_paternal_imprinting	2.14178701
11	MP0003121_genomic_imprinting	2.01106903
12	MP0003880_abnormal_central_pattern	2.00600609
13	MP0003195_calcinosis	2.00406284
14	MP0001502_abnormal_circadian_rhythm	1.99175877
15	MP0002638_abnormal_pupillary_reflex	1.99116559
16	MP0002160_abnormal_reproductive_system	1.97815839
17	MP0006276_abnormal_autonomic_nervous	1.91663025
18	MP0006292_abnormal_olfactory_placode	1.89295885
19	MP0001984_abnormal_olfaction	1.87343522
20	MP0005551_abnormal_eye_electrophysiolog	1.76789715
21	MP0001968_abnormal_touch/_nociception	1.69263848
22	MP0005389_reproductive_system_phenotype	1.69208503
23	MP0002837_dystrophic_cardiac_calcinosis	1.68621082
24	MP0001919_abnormal_reproductive_system	1.67606706
25	MP0000778_abnormal_nervous_system	1.67439848
26	MP0008789_abnormal_olfactory_epithelium	1.66590184
27	MP0008058_abnormal_DNA_repair	1.66088651
28	MP0002876_abnormal_thyroid_physiology	1.63584246
29	MP0004742_abnormal_vestibular_system	1.62413878
30	MP0005670_abnormal_white_adipose	1.62060562
31	MP0006072_abnormal_retinal_apoptosis	1.60022299
32	MP0004885_abnormal_endolymph	1.58475255
33	MP0001486_abnormal_startle_reflex	1.57782918
34	MP0001529_abnormal_vocalization	1.54627719
35	MP0002736_abnormal_nociception_after	1.50878381
36	MP0002272_abnormal_nervous_system	1.50027804
37	MP0000427_abnormal_hair_cycle	1.47077438
38	MP0008872_abnormal_physiological_respon	1.40881185
39	MP0002254_reproductive_system_inflammat	1.40578878
40	MP0001986_abnormal_taste_sensitivity	1.40468930
41	MP0000955_abnormal_spinal_cord	1.36537919
42	MP0005423_abnormal_somatic_nervous	1.34400960
43	MP0008775_abnormal_heart_ventricle	1.34038722
44	MP0005394_taste/olfaction_phenotype	1.33953511
45	MP0005499_abnormal_olfactory_system	1.33953511
46	MP0009046_muscle_twitch	1.33769046
47	MP0003567_abnormal_fetal_cardiomyocyte	1.32871655
48	MP0005379_endocrine/exocrine_gland_phen	1.29401270
49	MP0004147_increased_porphyrin_level	1.27796221
50	MP0002572_abnormal_emotion/affect_behav	1.27128435
51	MP0002822_catalepsy	1.26612849
52	MP0001293_anophthalmia	1.25727795
53	MP0003890_abnormal_embryonic-extraembry	1.23511347
54	MP0002102_abnormal_ear_morphology	1.21880460
55	MP0009745_abnormal_behavioral_response	1.21864114
56	MP0004924_abnormal_behavior	1.21801665
57	MP0005386_behavior/neurological_phenoty	1.21801665
58	MP0001970_abnormal_pain_threshold	1.21739327
59	MP0005671_abnormal_response_to	1.20983417
60	MP0005195_abnormal_posterior_eye	1.20776787
61	MP0009764_decreased_sensitivity_to	1.19091201
62	MP0005167_abnormal_blood-brain_barrier	1.19004656
63	MP0002735_abnormal_chemical_nociception	1.18836730
64	MP0002734_abnormal_mechanical_nocicepti	1.18683056
65	MP0002067_abnormal_sensory_capabilities	1.15605214
66	MP0001501_abnormal_sleep_pattern	1.13783593
67	MP0002064_seizures	1.12997379
68	MP0001905_abnormal_dopamine_level	1.10948811
69	MP0002063_abnormal_learning/memory/cond	1.08288757
70	MP0003136_yellow_coat_color	1.07089811
71	MP0002557_abnormal_social/conspecific_i	1.03515272
72	MP0002938_white_spotting	1.02886670
73	MP0004859_abnormal_synaptic_plasticity	1.02601614
74	MP0002210_abnormal_sex_determination	1.02592716
75	MP0005084_abnormal_gallbladder_morpholo	1.01988889
76	MP0002184_abnormal_innervation	1.00720579
77	MP0003638_abnormal_response/metabolism_	1.00263311
78	MP0005253_abnormal_eye_physiology	0.97825488
79	MP0008875_abnormal_xenobiotic_pharmacok	0.96728387
80	MP0000685_abnormal_immune_system	0.95659263
81	MP0001963_abnormal_hearing_physiology	0.95614535
82	MP0002752_abnormal_somatic_nervous	0.93780483
83	MP0005645_abnormal_hypothalamus_physiol	0.91541667
84	MP0001188_hyperpigmentation	0.90850829
85	MP0004019_abnormal_vitamin_homeostasis	0.90217206
86	MP0001145_abnormal_male_reproductive	0.90198042
87	MP0004133_heterotaxia	0.90032414
88	MP0001929_abnormal_gametogenesis	0.86992645
89	MP0001440_abnormal_grooming_behavior	0.86339175
90	MP0003635_abnormal_synaptic_transmissio	0.85366212
91	MP0003698_abnormal_male_reproductive	0.84832466
92	MP0000653_abnormal_sex_gland	0.84305045
93	MP0002229_neurodegeneration	0.83319193
94	MP0002733_abnormal_thermal_nociception	0.79353192
95	MP0002882_abnormal_neuron_morphology	0.77694792
96	MP0000631_abnormal_neuroendocrine_gland	0.76647115
97	MP0003942_abnormal_urinary_system	0.75103193
98	MP0000566_synostosis	0.73231055
99	MP0004145_abnormal_muscle_electrophysio	0.71818030
100	MP0000613_abnormal_salivary_gland	0.71718748

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	6.40059488
2	Reticulocytopenia (HP:0001896)	5.14737965
3	Abnormal rod and cone electroretinograms (HP:0008323)	5.00827431
4	Visual hallucinations (HP:0002367)	4.53286226
5	Abnormality of cells of the erythroid lineage (HP:0012130)	3.90263105
6	Abnormality of the labia minora (HP:0012880)	3.79937396
7	Medial flaring of the eyebrow (HP:0010747)	3.49435139
8	Adrenal hypoplasia (HP:0000835)	3.44224372
9	Constricted visual fields (HP:0001133)	3.29072489
10	Aplasia/Hypoplasia of the spleen (HP:0010451)	3.25657672
11	Asplenia (HP:0001746)	3.22191731
12	Termporal pattern (HP:0011008)	3.20910622
13	Insidious onset (HP:0003587)	3.20910622
14	Septo-optic dysplasia (HP:0100842)	3.17306533
15	Macrocytic anemia (HP:0001972)	3.11974552
16	Testicular atrophy (HP:0000029)	3.10320560
17	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.10149053
18	Entropion (HP:0000621)	3.09012621
19	Congenital stationary night blindness (HP:0007642)	3.01887691
20	Metaphyseal dysplasia (HP:0100255)	2.97544556
21	Acute necrotizing encephalopathy (HP:0006965)	2.86981197
22	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.82774020
23	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.82774020
24	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.82266324
25	Gait imbalance (HP:0002141)	2.79814208
26	Type II lissencephaly (HP:0007260)	2.75369751
27	Congenital primary aphakia (HP:0007707)	2.74630115
28	Autoimmune thrombocytopenia (HP:0001973)	2.69734395
29	Hypomagnesemia (HP:0002917)	2.66721145
30	Oligodactyly (hands) (HP:0001180)	2.63708423
31	Pendular nystagmus (HP:0012043)	2.62487246
32	Dyschromatopsia (HP:0007641)	2.59167519
33	Polyuria (HP:0000103)	2.57956932
34	Agitation (HP:0000713)	2.53518417
35	Acute encephalopathy (HP:0006846)	2.48557638
36	Abnormality of the renal cortex (HP:0011035)	2.48555187
37	Abnormal number of erythroid precursors (HP:0012131)	2.47058955
38	Supernumerary spleens (HP:0009799)	2.44848105
39	Oligodactyly (HP:0012165)	2.37876319
40	Stenosis of the external auditory canal (HP:0000402)	2.37776518
41	Absent thumb (HP:0009777)	2.37196138
42	Anterior segment dysgenesis (HP:0007700)	2.37173628
43	Abnormal pancreas size (HP:0012094)	2.36329553
44	Growth hormone deficiency (HP:0000824)	2.35311934
45	Abnormal mitochondria in muscle tissue (HP:0008316)	2.33765173
46	Progressive macrocephaly (HP:0004481)	2.31869126
47	Molar tooth sign on MRI (HP:0002419)	2.31395837
48	Abnormality of midbrain morphology (HP:0002418)	2.31395837
49	Cerebellar dysplasia (HP:0007033)	2.30697808
50	Nephrogenic diabetes insipidus (HP:0009806)	2.29806730
51	Type 2 muscle fiber atrophy (HP:0003554)	2.24322348
52	Optic disc pallor (HP:0000543)	2.22984876
53	Hyperventilation (HP:0002883)	2.21208155
54	Squamous cell carcinoma (HP:0002860)	2.20421282
55	Nephronophthisis (HP:0000090)	2.19293775
56	Mitochondrial inheritance (HP:0001427)	2.19080936
57	Abnormality of DNA repair (HP:0003254)	2.14611955
58	Anomalous pulmonary venous return (HP:0010772)	2.11392622
59	Polydipsia (HP:0001959)	2.10805166
60	Abnormal drinking behavior (HP:0030082)	2.10805166
61	Abnormal hemoglobin (HP:0011902)	2.09625512
62	Abnormality of magnesium homeostasis (HP:0004921)	2.07378988
63	Abnormal urine output (HP:0012590)	2.04751491
64	Pachygyria (HP:0001302)	2.04461287
65	Abnormality of the corticospinal tract (HP:0002492)	2.04324153
66	Genital tract atresia (HP:0001827)	2.03909434
67	3-Methylglutaconic aciduria (HP:0003535)	2.03246351
68	Prostate neoplasm (HP:0100787)	2.02847059
69	Colon cancer (HP:0003003)	2.02715945
70	Increased cerebral lipofuscin (HP:0011813)	2.01823401
71	Genetic anticipation (HP:0003743)	2.01820450
72	Abnormality of the renal medulla (HP:0100957)	1.99046011
73	Oligomenorrhea (HP:0000876)	1.98450811
74	Vaginal atresia (HP:0000148)	1.98068855
75	Horseshoe kidney (HP:0000085)	1.97710092
76	Abnormality of purine metabolism (HP:0004352)	1.96842912
77	Increased CSF lactate (HP:0002490)	1.96578097
78	Congenital, generalized hypertrichosis (HP:0004540)	1.93373522
79	Poor coordination (HP:0002370)	1.93149700
80	Confusion (HP:0001289)	1.91183328
81	Pallor (HP:0000980)	1.90575521
82	Central scotoma (HP:0000603)	1.90347699
83	Ectopic kidney (HP:0000086)	1.90147182
84	Pancreatic cysts (HP:0001737)	1.89185115
85	Abnormality of renal excretion (HP:0011036)	1.89084091
86	Pancreatic fibrosis (HP:0100732)	1.87053428
87	Fair hair (HP:0002286)	1.84933289
88	Muscle fiber atrophy (HP:0100295)	1.82943213
89	Hepatocellular necrosis (HP:0001404)	1.81952402
90	Congenital malformation of the right heart (HP:0011723)	1.81441493
91	Double outlet right ventricle (HP:0001719)	1.81441493
92	Focal motor seizures (HP:0011153)	1.81398630
93	Septate vagina (HP:0001153)	1.79713341
94	Enlarged penis (HP:0000040)	1.78464022
95	Inability to walk (HP:0002540)	1.78231126
96	Poikiloderma (HP:0001029)	1.77256212
97	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.76739151
98	Forearm undergrowth (HP:0009821)	1.75851979
99	Decreased central vision (HP:0007663)	1.75792176
100	Myokymia (HP:0002411)	1.75315104

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK1	3.65137424
2	TIE1	3.61613264
3	MAP3K11	3.29135966
4	MAP4K2	3.12280302
5	PIK3CA	2.90971616
6	FRK	2.39285912
7	WNK4	2.36665173
8	PINK1	2.35050715
9	KIT	2.30516514
10	TXK	2.03548620
11	GRK1	2.00912395
12	MAP3K12	1.89454228
13	CDC7	1.88555827
14	FLT3	1.85446408
15	ADRBK2	1.85239734
16	STK16	1.82362390
17	MAP4K1	1.79831418
18	STK39	1.74632958
19	DYRK2	1.68253112
20	EIF2AK1	1.57526669
21	PASK	1.56158175
22	CDK19	1.47910560
23	TAOK3	1.47530354
24	ICK	1.43095596
25	AKT3	1.39975411
26	PNCK	1.35673795
27	DAPK3	1.27816116
28	TAF1	1.19412550
29	TEC	1.18431255
30	PIK3CG	1.17713161
31	PRKCG	1.15615621
32	EPHB2	1.15083327
33	EPHA4	1.10013666
34	EPHA3	1.06778508
35	MKNK1	1.05979096
36	ZAK	1.03963217
37	TLK1	1.03024199
38	WNK3	1.00025451
39	MARK3	0.96752095
40	LRRK2	0.96696744
41	IKBKB	0.91420785
42	CASK	0.90189139
43	TNIK	0.90098743
44	PRKCQ	0.89526986
45	OXSR1	0.83332729
46	CCNB1	0.80553172
47	NEK2	0.77619549
48	INSRR	0.76754256
49	CAMK2D	0.76377166
50	BRAF	0.73826823
51	PLK1	0.70879459
52	TNK2	0.70152877
53	DAPK2	0.68993629
54	WEE1	0.68888114
55	PHKG1	0.68757100
56	PHKG2	0.68757100
57	SRPK1	0.68445417
58	PRKACA	0.68440015
59	CAMKK2	0.68368494
60	MAP2K4	0.68202877
61	SGK1	0.66523177
62	MARK1	0.65599285
63	AURKA	0.65327012
64	SIK2	0.65214960
65	CSNK2A2	0.64644852
66	PAK3	0.64547236
67	ADRBK1	0.63707678
68	MAPKAPK5	0.62511946
69	GRK7	0.60443485
70	STK11	0.58400355
71	CSNK1E	0.57932949
72	NME1	0.55736287
73	RPS6KB2	0.55178907
74	PRKCD	0.55027889
75	CAMK2A	0.55017439
76	CSNK1A1	0.54913010
77	GSK3A	0.54739924
78	MAPK12	0.54633040
79	WNK1	0.54356927
80	MAP2K6	0.53403397
81	MKNK2	0.49917739
82	CSF1R	0.49555701
83	RPS6KA6	0.49408329
84	TGFBR1	0.49347337
85	CSNK2A1	0.48938147
86	MAP3K4	0.48017688
87	KSR1	0.47451314
88	BRSK1	0.47193527
89	PRKCZ	0.47123662
90	MATK	0.45680681
91	OBSCN	0.44860798
92	CAMK2G	0.44504860
93	PRKG1	0.44369078
94	SGK223	0.43888755
95	SGK494	0.43888755
96	MAP2K7	0.42093163
97	RPS6KA5	0.41551624
98	PRKCA	0.40924712
99	NTRK2	0.39302261
100	SYK	0.38464594

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.82983756
2	RNA polymerase_Homo sapiens_hsa03020	3.40947421
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.24407310
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.07389173
5	Parkinsons disease_Homo sapiens_hsa05012	2.69596878
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.58897252
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.19628195
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.09574931
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.07472494
10	Huntingtons disease_Homo sapiens_hsa05016	2.02914084
11	Ether lipid metabolism_Homo sapiens_hsa00565	1.98789007
12	Phototransduction_Homo sapiens_hsa04744	1.92513248
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.86867475
14	Proteasome_Homo sapiens_hsa03050	1.86371936
15	Alzheimers disease_Homo sapiens_hsa05010	1.85337560
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.84349373
17	Nicotine addiction_Homo sapiens_hsa05033	1.81773063
18	Basal transcription factors_Homo sapiens_hsa03022	1.80846134
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.73040886
20	Caffeine metabolism_Homo sapiens_hsa00232	1.66639970
21	Homologous recombination_Homo sapiens_hsa03440	1.61613896
22	RNA degradation_Homo sapiens_hsa03018	1.60778954
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.47776378
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.41097627
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.32705247
26	Protein export_Homo sapiens_hsa03060	1.29956869
27	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.26348684
28	Propanoate metabolism_Homo sapiens_hsa00640	1.22712051
29	Olfactory transduction_Homo sapiens_hsa04740	1.22326065
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.19403433
31	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.16376671
32	Purine metabolism_Homo sapiens_hsa00230	1.11725092
33	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.01667433
34	Glycerolipid metabolism_Homo sapiens_hsa00561	0.97892315
35	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.97639821
36	Tryptophan metabolism_Homo sapiens_hsa00380	0.96986546
37	Insulin secretion_Homo sapiens_hsa04911	0.96222099
38	Nucleotide excision repair_Homo sapiens_hsa03420	0.93618358
39	Fat digestion and absorption_Homo sapiens_hsa04975	0.92037294
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.87924370
41	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.86095268
42	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.85717535
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.85560571
44	Butanoate metabolism_Homo sapiens_hsa00650	0.83589416
45	Salivary secretion_Homo sapiens_hsa04970	0.83405850
46	Sulfur relay system_Homo sapiens_hsa04122	0.82596282
47	Morphine addiction_Homo sapiens_hsa05032	0.82464430
48	Non-homologous end-joining_Homo sapiens_hsa03450	0.82317525
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.81237450
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79942569
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.78928324
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.78445624
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76920993
54	Glutamatergic synapse_Homo sapiens_hsa04724	0.76139044
55	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.72925862
56	p53 signaling pathway_Homo sapiens_hsa04115	0.72717604
57	Metabolic pathways_Homo sapiens_hsa01100	0.72644762
58	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.70651318
59	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.69553691
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.69341775
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.69260729
62	Fatty acid degradation_Homo sapiens_hsa00071	0.68948626
63	Serotonergic synapse_Homo sapiens_hsa04726	0.67752475
64	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.67645150
65	Retinol metabolism_Homo sapiens_hsa00830	0.65796259
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65389220
67	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.63616374
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.63323889
69	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.61646647
70	Primary immunodeficiency_Homo sapiens_hsa05340	0.61198930
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61077380
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60883491
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60659471
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59892327
75	Taste transduction_Homo sapiens_hsa04742	0.59119480
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58471685
77	Mismatch repair_Homo sapiens_hsa03430	0.56233139
78	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.55741292
79	Base excision repair_Homo sapiens_hsa03410	0.54589000
80	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.53764149
81	Peroxisome_Homo sapiens_hsa04146	0.53184737
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.50029317
83	Spliceosome_Homo sapiens_hsa03040	0.48278341
84	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46018762
85	Basal cell carcinoma_Homo sapiens_hsa05217	0.44469821
86	GABAergic synapse_Homo sapiens_hsa04727	0.42810740
87	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.40857425
88	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.39005161
89	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36043142
90	One carbon pool by folate_Homo sapiens_hsa00670	0.32876196
91	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.32809141
92	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.32797930
93	Long-term depression_Homo sapiens_hsa04730	0.29988603
94	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.29276352
95	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.26562241
96	Antigen processing and presentation_Homo sapiens_hsa04612	0.26121478
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.25001757
98	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.24519402
99	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.23265226
100	Circadian entrainment_Homo sapiens_hsa04713	0.22623486

RPL35AP19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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