RPL35AP21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.84315944
2viral transcription (GO:0019083)6.68696368
3translational termination (GO:0006415)6.45042455
4maturation of SSU-rRNA (GO:0030490)6.43263737
5ribosomal small subunit biogenesis (GO:0042274)6.36433138
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.47093877
7protein targeting to ER (GO:0045047)5.39696665
8cotranslational protein targeting to membrane (GO:0006613)5.37441683
9translational elongation (GO:0006414)5.27529262
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.26350408
11DNA deamination (GO:0045006)5.09133734
12protein localization to endoplasmic reticulum (GO:0070972)5.06855564
13behavioral response to nicotine (GO:0035095)5.05588270
14cytidine deamination (GO:0009972)5.03065437
15cytidine metabolic process (GO:0046087)5.03065437
16cytidine catabolic process (GO:0006216)5.03065437
17viral life cycle (GO:0019058)4.85302881
18cellular protein complex disassembly (GO:0043624)4.84217081
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.59593860
20positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.50363069
21pyrimidine ribonucleoside catabolic process (GO:0046133)4.41474656
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.25301184
23translational initiation (GO:0006413)4.15403786
24protein complex disassembly (GO:0043241)4.02928950
25GTP biosynthetic process (GO:0006183)3.97909565
26energy coupled proton transport, down electrochemical gradient (GO:0015985)3.93950988
27ATP synthesis coupled proton transport (GO:0015986)3.93950988
28ribosomal large subunit biogenesis (GO:0042273)3.90234860
29regulation of regulatory T cell differentiation (GO:0045589)3.85930579
30macromolecular complex disassembly (GO:0032984)3.83712654
31regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.81057121
32regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.80096831
33positive regulation of T cell apoptotic process (GO:0070234)3.76263940
34negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.71284019
35regulation of isotype switching to IgG isotypes (GO:0048302)3.69980169
36protein targeting to membrane (GO:0006612)3.64317612
37translation (GO:0006412)3.59559028
38UTP biosynthetic process (GO:0006228)3.44359223
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.42294530
40protein neddylation (GO:0045116)3.35344066
41ribonucleoprotein complex biogenesis (GO:0022613)3.33868138
42neuron fate determination (GO:0048664)3.32907271
43cell proliferation in forebrain (GO:0021846)3.29792246
44protein complex biogenesis (GO:0070271)3.29412927
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.28849924
46NADH dehydrogenase complex assembly (GO:0010257)3.28849924
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.28849924
48UTP metabolic process (GO:0046051)3.27554815
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.26763749
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.26488035
51nuclear-transcribed mRNA catabolic process (GO:0000956)3.16456532
52cellular component biogenesis (GO:0044085)3.12595658
53epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.11094725
54male meiosis I (GO:0007141)3.02602813
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.00957087
56electron transport chain (GO:0022900)3.00908642
57respiratory electron transport chain (GO:0022904)2.97305989
58mitochondrial respiratory chain complex assembly (GO:0033108)2.95560551
59response to xenobiotic stimulus (GO:0009410)2.95322137
60mRNA catabolic process (GO:0006402)2.94656476
61regulation of immunoglobulin secretion (GO:0051023)2.90197589
62epithelial cilium movement (GO:0003351)2.89659008
63CTP biosynthetic process (GO:0006241)2.88313238
64CTP metabolic process (GO:0046036)2.88313238
65purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.87573829
66neurofilament cytoskeleton organization (GO:0060052)2.86297843
67biotin metabolic process (GO:0006768)2.85703917
68positive regulation of defense response to virus by host (GO:0002230)2.84661064
69hydrogen ion transmembrane transport (GO:1902600)2.81557288
70rRNA processing (GO:0006364)2.79298313
71rRNA metabolic process (GO:0016072)2.78383363
72purine nucleoside triphosphate biosynthetic process (GO:0009145)2.78087043
73head development (GO:0060322)2.74461947
74intraciliary transport (GO:0042073)2.73866901
75synaptic transmission, cholinergic (GO:0007271)2.72580568
76ncRNA 3-end processing (GO:0043628)2.69802855
77chaperone-mediated protein transport (GO:0072321)2.69598393
78adaptation of signaling pathway (GO:0023058)2.69488157
79positive regulation of lymphocyte apoptotic process (GO:0070230)2.68832105
80positive regulation of respiratory burst (GO:0060267)2.68650030
81tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68494168
82RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68494168
83myoblast migration (GO:0051451)2.67921524
84nonmotile primary cilium assembly (GO:0035058)2.67810925
85pyrimidine ribonucleoside metabolic process (GO:0046131)2.67038500
86platelet dense granule organization (GO:0060155)2.66003998
87negative regulation of T cell differentiation in thymus (GO:0033085)2.65267586
88substrate-independent telencephalic tangential migration (GO:0021826)2.65260512
89substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.65260512
90piRNA metabolic process (GO:0034587)2.63721608
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.63370756
92somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.63284124
93isotype switching (GO:0045190)2.63284124
94somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.63284124
95RNA catabolic process (GO:0006401)2.60053909
96protein peptidyl-prolyl isomerization (GO:0000413)2.57109693
97positive regulation of muscle cell apoptotic process (GO:0010661)2.56907154
98intracellular protein transmembrane import (GO:0044743)2.56789002
99pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.55726675
100proton transport (GO:0015992)2.53727913

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.35611828
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.66575841
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.99915523
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86913167
5VDR_22108803_ChIP-Seq_LS180_Human2.81709654
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73377219
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.62148465
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.54719021
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.52967097
10ZNF274_21170338_ChIP-Seq_K562_Hela2.47979993
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34848094
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.29645098
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16618312
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09352194
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91803058
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88965426
17EZH2_27294783_Chip-Seq_ESCs_Mouse1.83928173
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.83038802
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.79042536
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78168757
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78051137
22IGF1R_20145208_ChIP-Seq_DFB_Human1.77424232
23MYC_18940864_ChIP-ChIP_HL60_Human1.68456835
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67088218
25VDR_23849224_ChIP-Seq_CD4+_Human1.54259263
26ERA_21632823_ChIP-Seq_H3396_Human1.50227524
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48876152
28REST_21632747_ChIP-Seq_MESCs_Mouse1.48479331
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.43978635
30NANOG_20526341_ChIP-Seq_ESCs_Human1.42022418
31EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.41766375
32FOXP3_21729870_ChIP-Seq_TREG_Human1.36998066
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.35881969
34TP53_22573176_ChIP-Seq_HFKS_Human1.35238404
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33348097
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.29849628
37XRN2_22483619_ChIP-Seq_HELA_Human1.29709220
38CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.29285126
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.28451720
40RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28313405
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27963244
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26761078
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25554125
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.25208831
45SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25031037
46TTF2_22483619_ChIP-Seq_HELA_Human1.24904213
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22606891
48TAF2_19829295_ChIP-Seq_ESCs_Human1.22521745
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.21785542
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.19306299
51MYC_19829295_ChIP-Seq_ESCs_Human1.18802535
52IRF1_19129219_ChIP-ChIP_H3396_Human1.18548328
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.17867407
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17430698
55RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15888906
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14872464
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14451620
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13205707
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12886923
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12886923
61ELK1_19687146_ChIP-ChIP_HELA_Human1.12306802
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11321285
63RNF2_27304074_Chip-Seq_NSC_Mouse1.10799675
64NCOR_22424771_ChIP-Seq_293T_Human1.10756897
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.09150369
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09150369
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07753698
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07237143
69GATA3_21867929_ChIP-Seq_TH1_Mouse1.06955053
70ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06918786
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06226690
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06226337
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05847937
74FUS_26573619_Chip-Seq_HEK293_Human1.04777745
75EWS_26573619_Chip-Seq_HEK293_Human1.03742853
76TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02438954
77YY1_22570637_ChIP-Seq_MALME-3M_Human1.02145128
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.01531657
79ELK1_22589737_ChIP-Seq_MCF10A_Human1.00555158
80FOXH1_21741376_ChIP-Seq_ESCs_Human0.94938896
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94674764
82ERG_21242973_ChIP-ChIP_JURKAT_Human0.94270813
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93592393
84AR_20517297_ChIP-Seq_VCAP_Human0.92841230
85P53_21459846_ChIP-Seq_SAOS-2_Human0.91708745
86SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91546257
87ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91529230
88AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91246112
89SMAD3_21741376_ChIP-Seq_ESCs_Human0.90947090
90FLI1_27457419_Chip-Seq_LIVER_Mouse0.88733948
91GABP_19822575_ChIP-Seq_HepG2_Human0.88708639
92LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88357969
93RNF2_18974828_ChIP-Seq_MESCs_Mouse0.87674570
94EZH2_18974828_ChIP-Seq_MESCs_Mouse0.87674570
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87330789
96RING1B_27294783_Chip-Seq_ESCs_Mouse0.87018889
97ERG_20517297_ChIP-Seq_VCAP_Human0.86631116
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86316927
99PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86152378
100CTCF_27219007_Chip-Seq_Bcells_Human0.85416385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.20866160
2MP0006292_abnormal_olfactory_placode3.86320483
3MP0002102_abnormal_ear_morphology3.01537658
4MP0003122_maternal_imprinting2.59688206
5MP0001873_stomach_inflammation2.31718580
6MP0001348_abnormal_lacrimal_gland2.29720100
7MP0003646_muscle_fatigue2.21763145
8MP0002653_abnormal_ependyma_morphology2.18184484
9MP0004142_abnormal_muscle_tone2.15324269
10MP0003123_paternal_imprinting2.09250343
11MP0008877_abnormal_DNA_methylation2.08958550
12MP0003787_abnormal_imprinting2.05009286
13MP0003878_abnormal_ear_physiology2.03776201
14MP0005377_hearing/vestibular/ear_phenot2.03776201
15MP0008789_abnormal_olfactory_epithelium2.03302863
16MP0001968_abnormal_touch/_nociception1.95203934
17MP0004885_abnormal_endolymph1.93836337
18MP0005671_abnormal_response_to1.89510996
19MP0003880_abnormal_central_pattern1.84448834
20MP0003121_genomic_imprinting1.78347105
21MP0002876_abnormal_thyroid_physiology1.77587879
22MP0005423_abnormal_somatic_nervous1.77332574
23MP0005394_taste/olfaction_phenotype1.66523549
24MP0005499_abnormal_olfactory_system1.66523549
25MP0002234_abnormal_pharynx_morphology1.65006425
26MP0000778_abnormal_nervous_system1.64995370
27MP0006276_abnormal_autonomic_nervous1.64198822
28MP0001835_abnormal_antigen_presentation1.58233724
29MP0002736_abnormal_nociception_after1.57743692
30MP0002272_abnormal_nervous_system1.50575178
31MP0008872_abnormal_physiological_respon1.48852835
32MP0006072_abnormal_retinal_apoptosis1.46326559
33MP0000049_abnormal_middle_ear1.46046032
34MP0004133_heterotaxia1.45902663
35MP0004742_abnormal_vestibular_system1.44158698
36MP0002638_abnormal_pupillary_reflex1.41285094
37MP0002837_dystrophic_cardiac_calcinosis1.40815084
38MP0001485_abnormal_pinna_reflex1.40648516
39MP0004145_abnormal_muscle_electrophysio1.40644584
40MP0001919_abnormal_reproductive_system1.35597274
41MP0001986_abnormal_taste_sensitivity1.35486339
42MP0005551_abnormal_eye_electrophysiolog1.33521051
43MP0002163_abnormal_gland_morphology1.32915941
44MP0002938_white_spotting1.28746392
45MP0001293_anophthalmia1.24459517
46MP0003329_amyloid_beta_deposits1.23415329
47MP0005389_reproductive_system_phenotype1.23169507
48MP0002277_abnormal_respiratory_mucosa1.22086167
49MP0002557_abnormal_social/conspecific_i1.21640871
50MP0009745_abnormal_behavioral_response1.21104093
51MP0003879_abnormal_hair_cell1.20522426
52MP0000604_amyloidosis1.18014399
53MP0003890_abnormal_embryonic-extraembry1.17963459
54MP0005174_abnormal_tail_pigmentation1.17867221
55MP0000955_abnormal_spinal_cord1.12503194
56MP0002063_abnormal_learning/memory/cond1.11249989
57MP0002822_catalepsy1.08702013
58MP0000631_abnormal_neuroendocrine_gland1.08354564
59MP0000026_abnormal_inner_ear1.08217163
60MP0000685_abnormal_immune_system1.07135329
61MP0003635_abnormal_synaptic_transmissio1.05027264
62MP0008875_abnormal_xenobiotic_pharmacok1.04430718
63MP0002184_abnormal_innervation1.03568366
64MP0001970_abnormal_pain_threshold1.02973799
65MP0001440_abnormal_grooming_behavior1.02362518
66MP0003186_abnormal_redox_activity1.00921721
67MP0005646_abnormal_pituitary_gland1.00705982
68MP0004043_abnormal_pH_regulation0.99523241
69MP0002095_abnormal_skin_pigmentation0.99109908
70MP0005195_abnormal_posterior_eye0.97139853
71MP0002733_abnormal_thermal_nociception0.97079693
72MP0002752_abnormal_somatic_nervous0.95332958
73MP0003938_abnormal_ear_development0.95052050
74MP0001963_abnormal_hearing_physiology0.94756253
75MP0004859_abnormal_synaptic_plasticity0.94748747
76MP0003011_delayed_dark_adaptation0.91810957
77MP0003136_yellow_coat_color0.91084280
78MP0001529_abnormal_vocalization0.89918021
79MP0001984_abnormal_olfaction0.89578586
80MP0001905_abnormal_dopamine_level0.87571825
81MP0002734_abnormal_mechanical_nocicepti0.87374347
82MP0001324_abnormal_eye_pigmentation0.87283122
83MP0008569_lethality_at_weaning0.86990395
84MP0009333_abnormal_splenocyte_physiolog0.86638567
85MP0005253_abnormal_eye_physiology0.86337027
86MP0002572_abnormal_emotion/affect_behav0.86138997
87MP0002405_respiratory_system_inflammati0.82095025
88MP0001486_abnormal_startle_reflex0.79512111
89MP0001188_hyperpigmentation0.79086954
90MP0004782_abnormal_surfactant_physiolog0.78088961
91MP0004147_increased_porphyrin_level0.77939551
92MP0002067_abnormal_sensory_capabilities0.77468548
93MP0002229_neurodegeneration0.74921366
94MP0002210_abnormal_sex_determination0.73584073
95MP0002882_abnormal_neuron_morphology0.72689730
96MP0005379_endocrine/exocrine_gland_phen0.72515157
97MP0002735_abnormal_chemical_nociception0.71783252
98MP0000750_abnormal_muscle_regeneration0.71477513
99MP0001663_abnormal_digestive_system0.71300137
100MP0005075_abnormal_melanosome_morpholog0.71261717

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.28492553
2Acute necrotizing encephalopathy (HP:0006965)4.51073161
3Abnormality of midbrain morphology (HP:0002418)4.44726370
4Molar tooth sign on MRI (HP:0002419)4.44726370
5Abnormality of cells of the erythroid lineage (HP:0012130)3.99434445
6Acute encephalopathy (HP:0006846)3.90565840
7Abnormal mitochondria in muscle tissue (HP:0008316)3.87388483
8Mitochondrial inheritance (HP:0001427)3.63176438
9Progressive macrocephaly (HP:0004481)3.60829652
10Pancreatic fibrosis (HP:0100732)3.46277508
11Pancreatic cysts (HP:0001737)3.36684540
12Medial flaring of the eyebrow (HP:0010747)3.33151180
13Macrocytic anemia (HP:0001972)3.32492591
14Chronic hepatic failure (HP:0100626)3.22819850
15Increased CSF lactate (HP:0002490)3.21541603
16Nephronophthisis (HP:0000090)3.20912570
17Septo-optic dysplasia (HP:0100842)3.16542761
18Abnormal number of erythroid precursors (HP:0012131)3.02503335
19Tachypnea (HP:0002789)3.01520576
20Stomatitis (HP:0010280)2.97312563
21Asplenia (HP:0001746)2.93372358
22Hepatocellular necrosis (HP:0001404)2.91665394
23Pallor (HP:0000980)2.90684478
24Increased hepatocellular lipid droplets (HP:0006565)2.90612037
25Lipid accumulation in hepatocytes (HP:0006561)2.82223770
26Aplasia/Hypoplasia of the spleen (HP:0010451)2.81726363
27True hermaphroditism (HP:0010459)2.75664815
28Abnormality of the renal medulla (HP:0100957)2.59076994
29Hepatic necrosis (HP:0002605)2.59025814
30Cerebral edema (HP:0002181)2.56905615
31Congenital stationary night blindness (HP:0007642)2.56561038
32Gait imbalance (HP:0002141)2.54226146
33Type 2 muscle fiber atrophy (HP:0003554)2.53929218
34Optic disc pallor (HP:0000543)2.52396298
35Increased IgM level (HP:0003496)2.50063035
36Muscle fiber atrophy (HP:0100295)2.43521308
37Abnormal rod and cone electroretinograms (HP:0008323)2.40816014
38Renal Fanconi syndrome (HP:0001994)2.40299219
39Congenital primary aphakia (HP:0007707)2.39855250
40Retinal dysplasia (HP:0007973)2.34851814
41Colon cancer (HP:0003003)2.34316911
42Nephrogenic diabetes insipidus (HP:0009806)2.34085752
43Tubular atrophy (HP:0000092)2.32969108
44Supernumerary spleens (HP:0009799)2.31621577
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26615293
46Type II lissencephaly (HP:0007260)2.21757651
47Cystic liver disease (HP:0006706)2.20950152
48Abnormal drinking behavior (HP:0030082)2.18908304
49Polydipsia (HP:0001959)2.18908304
50Pendular nystagmus (HP:0012043)2.17220790
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14706980
52Sclerocornea (HP:0000647)2.12768256
53Postaxial foot polydactyly (HP:0001830)2.10969561
54Congenital hepatic fibrosis (HP:0002612)2.10214783
55Severe combined immunodeficiency (HP:0004430)2.09053141
56Abnormality of the renal cortex (HP:0011035)2.07932538
57Stenosis of the external auditory canal (HP:0000402)2.07817840
58IgG deficiency (HP:0004315)2.06545539
59Leukodystrophy (HP:0002415)2.06298493
60Rib fusion (HP:0000902)2.01043103
61Increased intramyocellular lipid droplets (HP:0012240)1.99730976
62Lethargy (HP:0001254)1.95808704
63Abnormality of the prostate (HP:0008775)1.95529974
64Abnormality of DNA repair (HP:0003254)1.94664088
65Myokymia (HP:0002411)1.93800032
66Poor coordination (HP:0002370)1.93776469
67Hyperglycinemia (HP:0002154)1.93268331
68Thyroiditis (HP:0100646)1.90496457
69Optic nerve hypoplasia (HP:0000609)1.90404677
70Agitation (HP:0000713)1.89626202
71Absent thumb (HP:0009777)1.89321338
72Pachygyria (HP:0001302)1.89114225
73Aplastic anemia (HP:0001915)1.88172871
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87125463
75Absent septum pellucidum (HP:0001331)1.86243843
76Hypoplasia of the ulna (HP:0003022)1.84327954
77Postaxial hand polydactyly (HP:0001162)1.82097048
78Maternal diabetes (HP:0009800)1.81509806
79Increased muscle lipid content (HP:0009058)1.80277233
80Anencephaly (HP:0002323)1.80277176
81Thyroid-stimulating hormone excess (HP:0002925)1.79799543
82Increased serum lactate (HP:0002151)1.77895726
83X-linked dominant inheritance (HP:0001423)1.77883562
84Oligodactyly (hands) (HP:0001180)1.75602732
85Polyuria (HP:0000103)1.75354326
86Depressed nasal ridge (HP:0000457)1.74331210
87Vaginal atresia (HP:0000148)1.73229754
88Abnormal hemoglobin (HP:0011902)1.73204274
89Central scotoma (HP:0000603)1.73033624
90Partial duplication of thumb phalanx (HP:0009944)1.72495540
91Hypoplasia of the pons (HP:0012110)1.71984555
92Lissencephaly (HP:0001339)1.71035593
93Abnormality of renal resorption (HP:0011038)1.70804162
94Abnormality of urine glucose concentration (HP:0011016)1.69171391
95Glycosuria (HP:0003076)1.69171391
96Optic nerve coloboma (HP:0000588)1.68052462
97Ketosis (HP:0001946)1.67069666
98Narrow forehead (HP:0000341)1.65877480
99Genital tract atresia (HP:0001827)1.65503680
100Abnormal biliary tract physiology (HP:0012439)1.64897992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.41174089
2WNK43.82446536
3TAOK33.27291627
4ADRBK23.21011356
5NME12.61793200
6DYRK22.55990882
7PINK12.52072623
8TLK12.50665048
9MAP4K22.32230483
10BMPR1B2.31246745
11GRK12.16328822
12NUAK12.09174535
13TRIM281.99927268
14TYRO31.91636490
15MST41.88232012
16ZAK1.72299583
17VRK21.67254956
18STK391.65244822
19NTRK21.60107599
20STK161.56960759
21MAP2K71.53122661
22BCKDK1.47597701
23PAK31.41210191
24CDK191.39980173
25FRK1.36404404
26VRK11.31255732
27FES1.29302991
28WNK11.25963646
29WNK31.25540257
30OXSR11.24851865
31CAMK11.17039575
32EPHB21.15315722
33PDK21.13023988
34TIE11.12559955
35PRKCG1.10648022
36LRRK21.03895626
37CAMKK10.90409215
38PRKCQ0.82739675
39MAP3K40.82596965
40CAMKK20.82348941
41MAPK130.77975823
42PIK3CA0.77065400
43ADRBK10.75346799
44CASK0.75105435
45ITK0.74064723
46PRKCH0.72877978
47INSRR0.72099671
48MAP3K110.71825465
49MINK10.70813949
50PHKG20.70093178
51PHKG10.70093178
52IKBKB0.69396303
53PKN10.69158433
54LIMK10.68795802
55GRK70.68255791
56MAPK150.68118496
57EPHA40.67993116
58TAF10.67888205
59MAP3K90.66301811
60MARK10.65816917
61SIK20.65020693
62PRKACA0.61425348
63SGK2230.57146741
64SGK4940.57146741
65NEK10.56954931
66BRAF0.54645073
67HIPK20.53963823
68PIM10.53758213
69CSNK1A1L0.52545571
70PASK0.51932425
71CAMK40.51014352
72PRKCD0.50829978
73CSNK2A20.50517986
74PRKCI0.49515077
75MUSK0.49343335
76ABL20.48617850
77ACVR1B0.47425829
78STK110.47058429
79LCK0.45785910
80CSNK1A10.45646363
81CSNK1G20.45225938
82CAMK1D0.44452330
83GRK50.44172544
84CSNK1G30.43507945
85CDK50.43457060
86EIF2AK10.43212774
87PRKCA0.42364551
88OBSCN0.41771381
89CDC70.40744045
90NTRK30.39884680
91ATR0.39346850
92CSNK1E0.38734242
93DAPK30.38582729
94DYRK1A0.37168761
95AURKB0.36943601
96PRKACB0.35896336
97MAP4K10.35768807
98KDR0.35400714
99CHUK0.34919013
100DYRK1B0.34410742

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.13385437
2Oxidative phosphorylation_Homo sapiens_hsa001903.90414356
3Parkinsons disease_Homo sapiens_hsa050123.11191255
4Proteasome_Homo sapiens_hsa030502.99172957
5Cardiac muscle contraction_Homo sapiens_hsa042602.70645397
6Primary immunodeficiency_Homo sapiens_hsa053402.43276409
7Alzheimers disease_Homo sapiens_hsa050102.32008940
8Huntingtons disease_Homo sapiens_hsa050162.28080531
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06667598
10Protein export_Homo sapiens_hsa030602.02282788
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01301930
12Regulation of autophagy_Homo sapiens_hsa041401.74855912
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69394727
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68145810
15Linoleic acid metabolism_Homo sapiens_hsa005911.59513342
16Basal transcription factors_Homo sapiens_hsa030221.58978371
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43690338
18Allograft rejection_Homo sapiens_hsa053301.42918491
19Nicotine addiction_Homo sapiens_hsa050331.41063567
20Caffeine metabolism_Homo sapiens_hsa002321.38251133
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38050939
22Phototransduction_Homo sapiens_hsa047441.36636207
23Asthma_Homo sapiens_hsa053101.36448897
24Autoimmune thyroid disease_Homo sapiens_hsa053201.36248134
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34362687
26Peroxisome_Homo sapiens_hsa041461.30961697
27RNA polymerase_Homo sapiens_hsa030201.27670026
28RNA degradation_Homo sapiens_hsa030181.23204269
29Steroid biosynthesis_Homo sapiens_hsa001001.20765053
30One carbon pool by folate_Homo sapiens_hsa006701.12420400
31Homologous recombination_Homo sapiens_hsa034401.10772097
32Collecting duct acid secretion_Homo sapiens_hsa049661.10016813
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08569636
34Nitrogen metabolism_Homo sapiens_hsa009101.05404034
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05244354
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.01751593
37Intestinal immune network for IgA production_Homo sapiens_hsa046720.99721879
38Type I diabetes mellitus_Homo sapiens_hsa049400.98222450
39T cell receptor signaling pathway_Homo sapiens_hsa046600.94911294
40Pyrimidine metabolism_Homo sapiens_hsa002400.92805784
41Vitamin digestion and absorption_Homo sapiens_hsa049770.92539723
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91505354
43Hematopoietic cell lineage_Homo sapiens_hsa046400.90770582
44Graft-versus-host disease_Homo sapiens_hsa053320.90057490
45Rheumatoid arthritis_Homo sapiens_hsa053230.89990197
46Propanoate metabolism_Homo sapiens_hsa006400.87523416
47Non-homologous end-joining_Homo sapiens_hsa034500.86052447
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86047831
49Sulfur relay system_Homo sapiens_hsa041220.84809465
50Folate biosynthesis_Homo sapiens_hsa007900.84357782
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83906873
52Hedgehog signaling pathway_Homo sapiens_hsa043400.83426281
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81934572
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80184561
55Nucleotide excision repair_Homo sapiens_hsa034200.79427473
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76147682
57Ether lipid metabolism_Homo sapiens_hsa005650.76089473
58Insulin secretion_Homo sapiens_hsa049110.75517156
59Olfactory transduction_Homo sapiens_hsa047400.71824707
60Morphine addiction_Homo sapiens_hsa050320.70542050
61Arachidonic acid metabolism_Homo sapiens_hsa005900.69362583
62Fanconi anemia pathway_Homo sapiens_hsa034600.66537307
63Metabolic pathways_Homo sapiens_hsa011000.63900271
64Fatty acid biosynthesis_Homo sapiens_hsa000610.63435722
65Mismatch repair_Homo sapiens_hsa034300.62672779
66Chemical carcinogenesis_Homo sapiens_hsa052040.62146617
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61496935
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58224814
69Basal cell carcinoma_Homo sapiens_hsa052170.56730259
70Fat digestion and absorption_Homo sapiens_hsa049750.56412485
71Butanoate metabolism_Homo sapiens_hsa006500.56398129
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53332418
73RNA transport_Homo sapiens_hsa030130.52457544
74Purine metabolism_Homo sapiens_hsa002300.50474251
75Retinol metabolism_Homo sapiens_hsa008300.50285891
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.49477481
77Taste transduction_Homo sapiens_hsa047420.48972801
78GABAergic synapse_Homo sapiens_hsa047270.48157572
79Glutamatergic synapse_Homo sapiens_hsa047240.47444271
80Spliceosome_Homo sapiens_hsa030400.47222025
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46170674
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45368843
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44540218
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43680813
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42800166
86Tryptophan metabolism_Homo sapiens_hsa003800.40917966
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40600465
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40195114
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39953278
90Circadian entrainment_Homo sapiens_hsa047130.36362646
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.31917872
92Vitamin B6 metabolism_Homo sapiens_hsa007500.31875842
93Serotonergic synapse_Homo sapiens_hsa047260.31538904
94Salivary secretion_Homo sapiens_hsa049700.31393523
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31297347
96Cholinergic synapse_Homo sapiens_hsa047250.31119426
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30693350
98Fatty acid degradation_Homo sapiens_hsa000710.30208077
99Glutathione metabolism_Homo sapiens_hsa004800.28880429
100Synaptic vesicle cycle_Homo sapiens_hsa047210.28659052

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