ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	5.73134357
2	behavioral response to nicotine (GO:0035095)	5.34806553
3	behavioral response to ethanol (GO:0048149)	5.26536427
4	somite rostral/caudal axis specification (GO:0032525)	4.72070831
5	regulation of meiosis I (GO:0060631)	4.66393809
6	protein K11-linked deubiquitination (GO:0035871)	4.56812824
7	regulation of translational termination (GO:0006449)	4.46300687
8	DNA replication checkpoint (GO:0000076)	4.43231012
9	protein localization to cilium (GO:0061512)	4.43001096
10	replication fork processing (GO:0031297)	4.36636220
11	response to pheromone (GO:0019236)	4.32136770
12	limb bud formation (GO:0060174)	4.23625923
13	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.05586022
14	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.05586022
15	regulation of translation, ncRNA-mediated (GO:0045974)	4.05586022
16	glial cell proliferation (GO:0014009)	3.86241261
17	centriole replication (GO:0007099)	3.78630779
18	positive regulation of growth hormone secretion (GO:0060124)	3.67181205
19	heterochromatin organization (GO:0070828)	3.66362117
20	nuclear pore complex assembly (GO:0051292)	3.65386490
21	chromatin remodeling at centromere (GO:0031055)	3.64243829
22	inner ear receptor cell development (GO:0060119)	3.59553308
23	adenosine metabolic process (GO:0046085)	3.56044647
24	ventricular system development (GO:0021591)	3.49220605
25	left/right axis specification (GO:0070986)	3.46650585
26	paraxial mesoderm development (GO:0048339)	3.43089894
27	intraciliary transport (GO:0042073)	3.40951351
28	DNA catabolic process, exonucleolytic (GO:0000738)	3.40519215
29	embryonic foregut morphogenesis (GO:0048617)	3.38558005
30	kidney morphogenesis (GO:0060993)	3.37574231
31	regulation of growth hormone secretion (GO:0060123)	3.36911366
32	nucleobase biosynthetic process (GO:0046112)	3.36052112
33	DNA damage response, detection of DNA damage (GO:0042769)	3.31845863
34	phosphatidylethanolamine metabolic process (GO:0046337)	3.26834006
35	ectoderm development (GO:0007398)	3.26123360
36	synaptic transmission, cholinergic (GO:0007271)	3.25946218
37	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.24607461
38	nuclear pore organization (GO:0006999)	3.23155780
39	protein targeting to lysosome (GO:0006622)	3.19663122
40	establishment of protein localization to vacuole (GO:0072666)	3.19663122
41	protein targeting to vacuole (GO:0006623)	3.19663122
42	tryptophan catabolic process (GO:0006569)	3.15579331
43	indole-containing compound catabolic process (GO:0042436)	3.15579331
44	indolalkylamine catabolic process (GO:0046218)	3.15579331
45	positive regulation of meiosis (GO:0045836)	3.14362334
46	cullin deneddylation (GO:0010388)	3.13066379
47	protein deneddylation (GO:0000338)	3.11102042
48	peptidyl-histidine modification (GO:0018202)	3.09447339
49	positive regulation of male gonad development (GO:2000020)	3.09361618
50	neural tube formation (GO:0001841)	3.02704076
51	pore complex assembly (GO:0046931)	2.99440451
52	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.97160834
53	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.96457112
54	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.96381173
55	olfactory bulb development (GO:0021772)	2.95403607
56	keratinocyte development (GO:0003334)	2.90866842
57	protein prenylation (GO:0018342)	2.90624796
58	prenylation (GO:0097354)	2.90624796
59	regulation of hippo signaling (GO:0035330)	2.89452524
60	negative regulation of interleukin-1 beta production (GO:0032691)	2.89407245
61	presynaptic membrane assembly (GO:0097105)	2.89212937
62	positive regulation of meiotic cell cycle (GO:0051446)	2.88916538
63	regulation of centrosome duplication (GO:0010824)	2.86964731
64	mitochondrial DNA replication (GO:0006264)	2.86871635
65	double-strand break repair via homologous recombination (GO:0000724)	2.85103584
66	N-terminal protein amino acid acetylation (GO:0006474)	2.83581906
67	RNA localization (GO:0006403)	2.83486522
68	recombinational repair (GO:0000725)	2.82190219
69	negative regulation of telomere maintenance (GO:0032205)	2.81972074
70	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.81693132
71	negative regulation of mRNA processing (GO:0050686)	2.80034199
72	protein K6-linked ubiquitination (GO:0085020)	2.76046556
73	stress granule assembly (GO:0034063)	2.75992031
74	regulation of centriole replication (GO:0046599)	2.72176124
75	purine deoxyribonucleotide catabolic process (GO:0009155)	2.72079366
76	DNA-dependent DNA replication (GO:0006261)	2.72043772
77	negative regulation of DNA recombination (GO:0045910)	2.71533090
78	DNA integration (GO:0015074)	2.68760102
79	positive regulation of RNA splicing (GO:0033120)	2.64321359
80	cell wall macromolecule catabolic process (GO:0016998)	2.62995483
81	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.61346363
82	platelet dense granule organization (GO:0060155)	2.61134817
83	microtubule anchoring (GO:0034453)	2.59362449
84	dentate gyrus development (GO:0021542)	2.59346622
85	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.59133657
86	sperm motility (GO:0030317)	2.58372078
87	hindbrain development (GO:0030902)	2.57785879
88	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.57077895
89	mismatch repair (GO:0006298)	2.56596828
90	positive regulation of mRNA processing (GO:0050685)	2.53712723
91	postreplication repair (GO:0006301)	2.53597594
92	dopamine biosynthetic process (GO:0042416)	2.53529071
93	sulfation (GO:0051923)	2.52793170
94	retinal cone cell development (GO:0046549)	2.52070886
95	cardiac right ventricle morphogenesis (GO:0003215)	2.50860422
96	tryptophan metabolic process (GO:0006568)	2.50435442
97	S-adenosylmethionine metabolic process (GO:0046500)	2.49936616
98	synapsis (GO:0007129)	2.49432888
99	regulation of sulfur metabolic process (GO:0042762)	2.48807927
100	negative regulation of neurotransmitter transport (GO:0051589)	2.48246330

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	5.09199038
2	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	3.32642942
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.22252212
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.75699662
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.75068133
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.70615637
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.64361535
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.63643524
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.63091761
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.59312823
11	FUS_26573619_Chip-Seq_HEK293_Human	2.57785431
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.40435873
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.36417634
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35051110
15	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.33722629
16	EWS_26573619_Chip-Seq_HEK293_Human	2.29463119
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.18405610
18	VDR_22108803_ChIP-Seq_LS180_Human	2.16260864
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.16144910
20	P300_19829295_ChIP-Seq_ESCs_Human	2.07499377
21	ELK1_19687146_ChIP-ChIP_HELA_Human	2.03347068
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.99438723
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.92756183
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.91284168
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89671775
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.77915758
27	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.76434532
28	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.76434532
29	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.68344172
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.67709236
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.67520553
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67511364
33	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.65022317
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.65020995
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65020995
36	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.63823768
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.60184644
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.60060296
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.58338438
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.56996807
41	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.56926877
42	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.56053175
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.54574904
44	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.49653690
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.49637796
46	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.48651331
47	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.47472999
48	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.46539191
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46473775
50	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.45020718
51	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.41228494
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39755962
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36936602
54	STAT3_23295773_ChIP-Seq_U87_Human	1.36432637
55	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.36068009
56	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.35488061
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.32685835
58	TCF4_23295773_ChIP-Seq_U87_Human	1.31776674
59	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.31041719
60	AR_25329375_ChIP-Seq_VCAP_Human	1.30261191
61	P53_22387025_ChIP-Seq_ESCs_Mouse	1.29936175
62	MYC_18940864_ChIP-ChIP_HL60_Human	1.28118827
63	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.27784066
64	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.26847330
65	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.26621804
66	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.25649597
67	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.25366263
68	P300_18555785_Chip-Seq_ESCs_Mouse	1.25052497
69	VDR_23849224_ChIP-Seq_CD4+_Human	1.24439405
70	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.24307901
71	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.17733036
72	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.15889501
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15782755
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15782755
75	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.13942734
76	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.13794620
77	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.13206188
78	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.12748269
79	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.12541019
80	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.11313173
81	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.10690430
82	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.10097261
83	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.07319621
84	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06354402
85	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.04751481
86	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04269484
87	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.04028300
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03430866
89	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.02414336
90	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.02202229
91	TP53_22573176_ChIP-Seq_HFKS_Human	1.00198196
92	E2F7_22180533_ChIP-Seq_HELA_Human	0.99534868
93	RNF2_27304074_Chip-Seq_NSC_Mouse	0.98617078
94	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98346255
95	ER_23166858_ChIP-Seq_MCF-7_Human	0.97934475
96	IRF1_19129219_ChIP-ChIP_H3396_Human	0.97802695
97	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.97699286
98	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.96926299
99	TP53_16413492_ChIP-PET_HCT116_Human	0.95024072
100	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.92686736

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009697_abnormal_copulation	5.13067117
2	MP0004043_abnormal_pH_regulation	3.90466078
3	MP0003123_paternal_imprinting	3.71653015
4	MP0002102_abnormal_ear_morphology	3.25637643
5	MP0008057_abnormal_DNA_replication	3.17004433
6	MP0003880_abnormal_central_pattern	2.75265677
7	MP0006072_abnormal_retinal_apoptosis	2.60330804
8	MP0000516_abnormal_urinary_system	2.50544705
9	MP0005367_renal/urinary_system_phenotyp	2.50544705
10	MP0002938_white_spotting	2.39150294
11	MP0006292_abnormal_olfactory_placode	2.28919967
12	MP0010234_abnormal_vibrissa_follicle	2.25204413
13	MP0005253_abnormal_eye_physiology	2.10433413
14	MP0001188_hyperpigmentation	2.08170556
15	MP0004147_increased_porphyrin_level	2.06534705
16	MP0008058_abnormal_DNA_repair	2.03024735
17	MP0003195_calcinosis	2.00872133
18	MP0000569_abnormal_digit_pigmentation	1.99124866
19	MP0005075_abnormal_melanosome_morpholog	1.93054842
20	MP0001293_anophthalmia	1.92383502
21	MP0005551_abnormal_eye_electrophysiolog	1.87603315
22	MP0002090_abnormal_vision	1.87544075
23	MP0008789_abnormal_olfactory_epithelium	1.87474015
24	MP0003121_genomic_imprinting	1.85105331
25	MP0000372_irregular_coat_pigmentation	1.79851856
26	MP0010094_abnormal_chromosome_stability	1.76705963
27	MP0000015_abnormal_ear_pigmentation	1.72523878
28	MP0003950_abnormal_plasma_membrane	1.66625284
29	MP0008877_abnormal_DNA_methylation	1.64181797
30	MP0001727_abnormal_embryo_implantation	1.56643217
31	MP0005408_hypopigmentation	1.56545467
32	MP0000631_abnormal_neuroendocrine_gland	1.55686483
33	MP0002160_abnormal_reproductive_system	1.54994122
34	MP0002254_reproductive_system_inflammat	1.54346964
35	MP0003786_premature_aging	1.48827477
36	MP0001177_atelectasis	1.43791489
37	MP0001984_abnormal_olfaction	1.42669871
38	MP0002653_abnormal_ependyma_morphology	1.36059995
39	MP0003111_abnormal_nucleus_morphology	1.35564469
40	MP0001919_abnormal_reproductive_system	1.34398815
41	MP0003693_abnormal_embryo_hatching	1.31516249
42	MP0010352_gastrointestinal_tract_polyps	1.28474007
43	MP0004885_abnormal_endolymph	1.26172700
44	MP0003941_abnormal_skin_development	1.23772137
45	MP0000647_abnormal_sebaceous_gland	1.22752464
46	MP0005394_taste/olfaction_phenotype	1.22506481
47	MP0005499_abnormal_olfactory_system	1.22506481
48	MP0003718_maternal_effect	1.19490667
49	MP0005391_vision/eye_phenotype	1.19225758
50	MP0001486_abnormal_startle_reflex	1.18030299
51	MP0009745_abnormal_behavioral_response	1.16583786
52	MP0002233_abnormal_nose_morphology	1.13802387
53	MP0003787_abnormal_imprinting	1.13380868
54	MP0002751_abnormal_autonomic_nervous	1.12760797
55	MP0001529_abnormal_vocalization	1.12608797
56	MP0000778_abnormal_nervous_system	1.11071212
57	MP0003937_abnormal_limbs/digits/tail_de	1.10610110
58	MP0003755_abnormal_palate_morphology	1.08056178
59	MP0003698_abnormal_male_reproductive	1.02001382
60	MP0002736_abnormal_nociception_after	1.00733480
61	MP0002638_abnormal_pupillary_reflex	1.00421271
62	MP0005389_reproductive_system_phenotype	0.99021938
63	MP0003119_abnormal_digestive_system	0.97854194
64	MP0002095_abnormal_skin_pigmentation	0.96277417
65	MP0000427_abnormal_hair_cycle	0.96252710
66	MP0005195_abnormal_posterior_eye	0.94877179
67	MP0001324_abnormal_eye_pigmentation	0.94704904
68	MP0001286_abnormal_eye_development	0.93418674
69	MP0004264_abnormal_extraembryonic_tissu	0.93162348
70	MP0008932_abnormal_embryonic_tissue	0.92434204
71	MP0001929_abnormal_gametogenesis	0.91377585
72	MP0001485_abnormal_pinna_reflex	0.90884252
73	MP0008872_abnormal_physiological_respon	0.89282850
74	MP0008875_abnormal_xenobiotic_pharmacok	0.89243636
75	MP0001968_abnormal_touch/_nociception	0.88965684
76	MP0005174_abnormal_tail_pigmentation	0.86803534
77	MP0002109_abnormal_limb_morphology	0.81877902
78	MP0001186_pigmentation_phenotype	0.81216481
79	MP0000538_abnormal_urinary_bladder	0.80391482
80	MP0001764_abnormal_homeostasis	0.79875539
81	MP0006276_abnormal_autonomic_nervous	0.79052915
82	MP0002184_abnormal_innervation	0.77751671
83	MP0002075_abnormal_coat/hair_pigmentati	0.77038842
84	MP0003567_abnormal_fetal_cardiomyocyte	0.76848886
85	MP0005171_absent_coat_pigmentation	0.75938859
86	MP0002752_abnormal_somatic_nervous	0.75882375
87	MP0003890_abnormal_embryonic-extraembry	0.74650010
88	MP0004957_abnormal_blastocyst_morpholog	0.74346931
89	MP0000026_abnormal_inner_ear	0.73875819
90	MP0003861_abnormal_nervous_system	0.72748540
91	MP0000653_abnormal_sex_gland	0.71330065
92	MP0009703_decreased_birth_body	0.70395127
93	MP0003936_abnormal_reproductive_system	0.67598464
94	MP0010307_abnormal_tumor_latency	0.66949410
95	MP0001145_abnormal_male_reproductive	0.65346527
96	MP0002282_abnormal_trachea_morphology	0.64931226
97	MP0010678_abnormal_skin_adnexa	0.64476291
98	MP0002697_abnormal_eye_size	0.64402173
99	MP0002115_abnormal_skeleton_extremities	0.61931317
100	MP0004133_heterotaxia	0.60513426

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nephronophthisis (HP:0000090)	4.14850822
2	Hyperinsulinemic hypoglycemia (HP:0000825)	4.04852507
3	Neoplasm of the adrenal cortex (HP:0100641)	4.01944597
4	Abnormality of the renal medulla (HP:0100957)	3.64641905
5	Intestinal atresia (HP:0011100)	3.45265703
6	Abnormality of midbrain morphology (HP:0002418)	3.34553046
7	Molar tooth sign on MRI (HP:0002419)	3.34553046
8	Pancreatic fibrosis (HP:0100732)	3.07898958
9	Hypokalemic alkalosis (HP:0001949)	3.00827182
10	Pancreatic cysts (HP:0001737)	2.98095021
11	Oligodactyly (hands) (HP:0001180)	2.96964516
12	Postaxial foot polydactyly (HP:0001830)	2.96680419
13	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.96366274
14	Thyroiditis (HP:0100646)	2.91437627
15	Colon cancer (HP:0003003)	2.89718061
16	True hermaphroditism (HP:0010459)	2.82434162
17	Metabolic alkalosis (HP:0200114)	2.76760871
18	Hematochezia (HP:0002573)	2.66345017
19	Aqueductal stenosis (HP:0002410)	2.63183910
20	Increased circulating renin level (HP:0000848)	2.59938174
21	Pendular nystagmus (HP:0012043)	2.51312183
22	Oligodactyly (HP:0012165)	2.46008219
23	Albinism (HP:0001022)	2.44616170
24	Abnormality of the metopic suture (HP:0005556)	2.42534534
25	Ectopic kidney (HP:0000086)	2.41541350
26	Adrenal hypoplasia (HP:0000835)	2.40995450
27	Abnormality of the renal cortex (HP:0011035)	2.39623284
28	Gonadotropin excess (HP:0000837)	2.38382977
29	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.36432455
30	Hypoplastic iliac wings (HP:0002866)	2.35392534
31	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.34231122
32	Hypoplasia of the fovea (HP:0007750)	2.34231122
33	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.33958163
34	Absent speech (HP:0001344)	2.29787975
35	Abnormality of methionine metabolism (HP:0010901)	2.27771496
36	Chromsome breakage (HP:0040012)	2.27464042
37	Neoplasm of the adrenal gland (HP:0100631)	2.24793248
38	Abnormality of endocrine pancreas physiology (HP:0012093)	2.21669119
39	Abnormality of the pancreatic islet cells (HP:0006476)	2.21669119
40	Chronic bronchitis (HP:0004469)	2.20187429
41	Anophthalmia (HP:0000528)	2.19681782
42	Breast carcinoma (HP:0003002)	2.19260007
43	Abnormality of the parathyroid morphology (HP:0011766)	2.16300870
44	Calf muscle hypertrophy (HP:0008981)	2.16269264
45	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.14877678
46	Polyuria (HP:0000103)	2.11620515
47	Postaxial hand polydactyly (HP:0001162)	2.10975428
48	Congenital stationary night blindness (HP:0007642)	2.10791886
49	Preaxial hand polydactyly (HP:0001177)	2.08827036
50	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.08410990
51	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.07253270
52	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.07219101
53	Absent epiphyses (HP:0010577)	2.07219101
54	Supernumerary spleens (HP:0009799)	2.06980344
55	Thickened helices (HP:0000391)	2.06976895
56	Abnormality of chromosome stability (HP:0003220)	2.06451224
57	Cupped ear (HP:0000378)	2.02041986
58	Renal salt wasting (HP:0000127)	2.01658869
59	Sloping forehead (HP:0000340)	2.01026236
60	Prominent metopic ridge (HP:0005487)	2.00869487
61	Hypothermia (HP:0002045)	1.98279398
62	Cystic liver disease (HP:0006706)	1.95588877
63	Cerebellar dysplasia (HP:0007033)	1.94282534
64	Hyperglycinemia (HP:0002154)	1.93082779
65	Abnormality of the fovea (HP:0000493)	1.91555352
66	Ependymoma (HP:0002888)	1.90701340
67	Optic nerve hypoplasia (HP:0000609)	1.89828729
68	Abnormality of the labia minora (HP:0012880)	1.89820941
69	Abolished electroretinogram (ERG) (HP:0000550)	1.89465965
70	Anencephaly (HP:0002323)	1.88338217
71	Muscle hypertrophy of the lower extremities (HP:0008968)	1.87677698
72	Hyperventilation (HP:0002883)	1.84137962
73	Dandy-Walker malformation (HP:0001305)	1.83827676
74	Clubbing of toes (HP:0100760)	1.81877949
75	Occipital encephalocele (HP:0002085)	1.81030922
76	Renal hypoplasia (HP:0000089)	1.78881369
77	Bile duct proliferation (HP:0001408)	1.76746659
78	Abnormal biliary tract physiology (HP:0012439)	1.76746659
79	Hyperaldosteronism (HP:0000859)	1.76641167
80	Abnormality of alanine metabolism (HP:0010916)	1.75611850
81	Hyperalaninemia (HP:0003348)	1.75611850
82	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.75611850
83	Submucous cleft hard palate (HP:0000176)	1.75549457
84	Glioma (HP:0009733)	1.75053939
85	Fair hair (HP:0002286)	1.74567233
86	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.74395790
87	Abnormal lung lobation (HP:0002101)	1.74370788
88	Methylmalonic acidemia (HP:0002912)	1.73513654
89	Pancreatic islet-cell hyperplasia (HP:0004510)	1.73333334
90	Limb hypertonia (HP:0002509)	1.73043948
91	Abnormality of chromosome segregation (HP:0002916)	1.72757968
92	Rib fusion (HP:0000902)	1.72179824
93	Growth hormone deficiency (HP:0000824)	1.72155667
94	Partial agenesis of the corpus callosum (HP:0001338)	1.71902759
95	Abnormality of the duodenum (HP:0002246)	1.71543498
96	Narrow forehead (HP:0000341)	1.71505902
97	Abnormality of B cell number (HP:0010975)	1.71408328
98	Meckel diverticulum (HP:0002245)	1.71140086
99	B lymphocytopenia (HP:0010976)	1.70410523
100	Chorioretinal atrophy (HP:0000533)	1.70104335

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	6.50550029
2	NUAK1	4.80114974
3	TRIM28	4.32718132
4	FRK	4.32361049
5	AKT3	3.47433456
6	IRAK2	3.19016949
7	IRAK1	3.04527171
8	CDC7	2.80109438
9	PLK4	2.74668674
10	TNIK	2.43040457
11	PNCK	2.00911872
12	MAP4K2	1.91869613
13	EIF2AK3	1.88852439
14	FGFR2	1.77744271
15	NLK	1.74978826
16	STK38L	1.69585802
17	CDK9	1.68319188
18	PLK2	1.66609199
19	GRK1	1.62291521
20	STK3	1.60660447
21	ACVR1B	1.48035462
22	WNK3	1.47307508
23	ERBB3	1.44416277
24	WEE1	1.39566865
25	TTK	1.36932692
26	PLK3	1.36119375
27	VRK1	1.34489223
28	EPHA4	1.31759786
29	NTRK3	1.30580581
30	BRAF	1.26239508
31	ZAK	1.24257938
32	MKNK2	1.14480214
33	CDK8	1.03848609
34	EIF2AK1	1.01126865
35	BMPR1B	1.00749124
36	MST4	0.99518198
37	CAMK1D	0.99148127
38	BRSK2	0.98041922
39	MAPK13	0.95950125
40	BUB1	0.94966663
41	VRK2	0.91840970
42	PBK	0.85399202
43	CAMK1G	0.82168881
44	CSNK1G1	0.76105918
45	MKNK1	0.73103850
46	STK11	0.70882680
47	FER	0.69126648
48	OXSR1	0.65644402
49	ADRBK2	0.64490275
50	TAF1	0.62447811
51	DYRK2	0.61541333
52	PLK1	0.60340648
53	PIK3CG	0.60157586
54	TAOK1	0.52996004
55	MARK1	0.48501212
56	ATR	0.47638137
57	PRKCG	0.47236528
58	ATM	0.46008695
59	CSNK1G2	0.42601004
60	CSNK1G3	0.42517416
61	PINK1	0.42286482
62	EIF2AK2	0.42047881
63	PAK3	0.42015573
64	PRKCE	0.41924936
65	SGK2	0.40642070
66	INSRR	0.39110006
67	CDK19	0.38415687
68	TGFBR1	0.36655684
69	MELK	0.35173471
70	RPS6KA4	0.32093094
71	EPHB2	0.32092035
72	GRK5	0.31383835
73	MINK1	0.28290575
74	CDK3	0.25604159
75	CAMK1	0.24303900
76	CSNK1E	0.24094449
77	PRKG1	0.23877423
78	PRKAA2	0.23245467
79	SIK2	0.23135498
80	BRSK1	0.22796042
81	BCKDK	0.20761679
82	PRKCZ	0.20500888
83	PDK2	0.20369219
84	PHKG2	0.19666127
85	PHKG1	0.19666127
86	TSSK6	0.18508433
87	CHEK2	0.18083387
88	CSNK1D	0.17870987
89	BCR	0.17447533
90	NEK6	0.17237507
91	STK39	0.17190212
92	FGFR1	0.16880400
93	AURKB	0.16561952
94	MAP3K4	0.16395348
95	STK38	0.16089656
96	PRKDC	0.15625104
97	DYRK1A	0.15330100
98	PKN1	0.15193374
99	CHEK1	0.14745898
100	GSK3B	0.14172574

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.13268755
2	Propanoate metabolism_Homo sapiens_hsa00640	3.12607959
3	Mismatch repair_Homo sapiens_hsa03430	2.81860233
4	Sulfur metabolism_Homo sapiens_hsa00920	2.46286723
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.45097365
6	Homologous recombination_Homo sapiens_hsa03440	2.43697089
7	Basal transcription factors_Homo sapiens_hsa03022	2.42829675
8	Fatty acid elongation_Homo sapiens_hsa00062	2.41077753
9	Ether lipid metabolism_Homo sapiens_hsa00565	2.24060590
10	Nucleotide excision repair_Homo sapiens_hsa03420	2.23498466
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.22321102
12	Lysine degradation_Homo sapiens_hsa00310	2.09478134
13	Butanoate metabolism_Homo sapiens_hsa00650	2.07270536
14	Steroid biosynthesis_Homo sapiens_hsa00100	2.04653967
15	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.04350321
16	DNA replication_Homo sapiens_hsa03030	1.94056254
17	Nicotine addiction_Homo sapiens_hsa05033	1.93467788
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.84545321
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.73387437
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.66108633
21	RNA degradation_Homo sapiens_hsa03018	1.65805742
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.59657050
23	Phototransduction_Homo sapiens_hsa04744	1.56003814
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.53890621
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.52441490
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.52379572
27	Chemical carcinogenesis_Homo sapiens_hsa05204	1.49672522
28	Caffeine metabolism_Homo sapiens_hsa00232	1.45921332
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.44018727
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.36850641
31	One carbon pool by folate_Homo sapiens_hsa00670	1.36423029
32	RNA transport_Homo sapiens_hsa03013	1.33913242
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.31232075
34	Cell cycle_Homo sapiens_hsa04110	1.31135593
35	Taste transduction_Homo sapiens_hsa04742	1.29021227
36	Protein export_Homo sapiens_hsa03060	1.26093195
37	Proteasome_Homo sapiens_hsa03050	1.24016587
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.18655883
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.14687658
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.14594453
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.13012522
42	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.10436461
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.09824802
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.04483224
45	Regulation of autophagy_Homo sapiens_hsa04140	1.04373607
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02706709
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.00276178
48	p53 signaling pathway_Homo sapiens_hsa04115	0.96802726
49	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.96423132
50	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.96032573
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.93552506
52	Base excision repair_Homo sapiens_hsa03410	0.91849408
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.89530957
54	RNA polymerase_Homo sapiens_hsa03020	0.82831400
55	Insulin secretion_Homo sapiens_hsa04911	0.81883679
56	Cocaine addiction_Homo sapiens_hsa05030	0.80061262
57	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.77175082
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.76594115
59	Fat digestion and absorption_Homo sapiens_hsa04975	0.74350807
60	Fatty acid metabolism_Homo sapiens_hsa01212	0.74237408
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73312867
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.71185792
63	Retinol metabolism_Homo sapiens_hsa00830	0.71150488
64	Fatty acid degradation_Homo sapiens_hsa00071	0.70913566
65	Basal cell carcinoma_Homo sapiens_hsa05217	0.69504373
66	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.67034480
67	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.66013570
68	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.64415964
69	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.63746622
70	Hippo signaling pathway_Homo sapiens_hsa04390	0.63394358
71	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.62031893
72	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.59872878
73	Peroxisome_Homo sapiens_hsa04146	0.59711427
74	mRNA surveillance pathway_Homo sapiens_hsa03015	0.56513495
75	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.55707137
76	Olfactory transduction_Homo sapiens_hsa04740	0.54083593
77	Serotonergic synapse_Homo sapiens_hsa04726	0.53968345
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53527041
79	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52705289
80	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.52277606
81	FoxO signaling pathway_Homo sapiens_hsa04068	0.49419489
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49408615
83	Wnt signaling pathway_Homo sapiens_hsa04310	0.46956209
84	Histidine metabolism_Homo sapiens_hsa00340	0.46341804
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.44943936
86	Spliceosome_Homo sapiens_hsa03040	0.44160714
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.43736211
88	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42739240
89	Glutathione metabolism_Homo sapiens_hsa00480	0.41575902
90	Pyrimidine metabolism_Homo sapiens_hsa00240	0.40797689
91	Purine metabolism_Homo sapiens_hsa00230	0.40660567
92	Alcoholism_Homo sapiens_hsa05034	0.38636962
93	Metabolic pathways_Homo sapiens_hsa01100	0.38405637
94	Prostate cancer_Homo sapiens_hsa05215	0.38379577
95	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.38037345
96	Glucagon signaling pathway_Homo sapiens_hsa04922	0.37871259
97	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.35372210
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.34011322
99	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33876612
100	Tight junction_Homo sapiens_hsa04530	0.31530629

RPL35AP25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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