ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to xenobiotic stimulus (GO:0009410)	6.55546135
2	response to nitrosative stress (GO:0051409)	6.49789567
3	presynaptic membrane assembly (GO:0097105)	5.58526307
4	negative regulation of T cell differentiation in thymus (GO:0033085)	5.50251533
5	cysteine metabolic process (GO:0006534)	5.22063415
6	protein K11-linked deubiquitination (GO:0035871)	5.19949383
7	C4-dicarboxylate transport (GO:0015740)	4.87157469
8	cAMP catabolic process (GO:0006198)	4.79109522
9	presynaptic membrane organization (GO:0097090)	4.78202830
10	auditory behavior (GO:0031223)	4.67319571
11	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.59887991
12	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.59887991
13	regulation of translation, ncRNA-mediated (GO:0045974)	4.59887991
14	GTP biosynthetic process (GO:0006183)	4.40509526
15	mechanosensory behavior (GO:0007638)	4.18219621
16	ribosomal small subunit assembly (GO:0000028)	4.17760857
17	startle response (GO:0001964)	4.17616850
18	cyclic nucleotide catabolic process (GO:0009214)	4.11017613
19	nonmotile primary cilium assembly (GO:0035058)	4.02850289
20	positive regulation of T cell apoptotic process (GO:0070234)	4.00504243
21	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.00366099
22	regulation of action potential (GO:0098900)	3.93407551
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.87312038
24	L-ascorbic acid metabolic process (GO:0019852)	3.83689292
25	postsynaptic membrane organization (GO:0001941)	3.83246970
26	auditory receptor cell stereocilium organization (GO:0060088)	3.76397845
27	positive regulation of megakaryocyte differentiation (GO:0045654)	3.74846852
28	S-adenosylmethionine metabolic process (GO:0046500)	3.72422176
29	behavioral response to nicotine (GO:0035095)	3.68525821
30	UTP biosynthetic process (GO:0006228)	3.68400209
31	response to pheromone (GO:0019236)	3.65817989
32	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.59065885
33	positive regulation of action potential (GO:0045760)	3.52493500
34	heparin metabolic process (GO:0030202)	3.50965163
35	heparin biosynthetic process (GO:0030210)	3.50965163
36	piRNA metabolic process (GO:0034587)	3.50797187
37	positive regulation of fatty acid transport (GO:2000193)	3.50227960
38	protein complex biogenesis (GO:0070271)	3.48576213
39	regulation of meiosis I (GO:0060631)	3.43323478
40	protein-cofactor linkage (GO:0018065)	3.41832328
41	glutamate metabolic process (GO:0006536)	3.41197022
42	righting reflex (GO:0060013)	3.37807472
43	proteasome assembly (GO:0043248)	3.30285966
44	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.30184329
45	UTP metabolic process (GO:0046051)	3.30183792
46	axoneme assembly (GO:0035082)	3.29662445
47	ribosomal large subunit biogenesis (GO:0042273)	3.27068013
48	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.25736551
49	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.25736551
50	NADH dehydrogenase complex assembly (GO:0010257)	3.25736551
51	regulation of mitochondrial translation (GO:0070129)	3.24562864
52	regulation of mitochondrial depolarization (GO:0051900)	3.24331562
53	glutathione biosynthetic process (GO:0006750)	3.23971172
54	alkaloid metabolic process (GO:0009820)	3.23416194
55	spliceosomal complex assembly (GO:0000245)	3.21437280
56	positive regulation of prostaglandin secretion (GO:0032308)	3.18335346
57	ATP synthesis coupled proton transport (GO:0015986)	3.15192110
58	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.15192110
59	nonribosomal peptide biosynthetic process (GO:0019184)	3.14153814
60	telencephalon development (GO:0021537)	3.14142282
61	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	3.10032653
62	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.09625459
63	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.09625459
64	mitochondrial respiratory chain complex assembly (GO:0033108)	3.08818807
65	adrenergic receptor signaling pathway (GO:0071875)	3.08495697
66	cell proliferation in forebrain (GO:0021846)	3.04830784
67	DNA deamination (GO:0045006)	3.04244942
68	neurotransmitter catabolic process (GO:0042135)	3.03551427
69	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	3.00900611
70	tyrosine phosphorylation of STAT protein (GO:0007260)	2.98299785
71	synaptic transmission, cholinergic (GO:0007271)	2.96456568
72	intra-S DNA damage checkpoint (GO:0031573)	2.95220190
73	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.93848800
74	positive regulation of icosanoid secretion (GO:0032305)	2.93576302
75	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.92774714
76	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.90471025
77	regulation of T cell differentiation in thymus (GO:0033081)	2.88283523
78	regulation of membrane depolarization (GO:0003254)	2.87757724
79	membrane assembly (GO:0071709)	2.84585674
80	neuromuscular synaptic transmission (GO:0007274)	2.84345257
81	ovulation cycle (GO:0042698)	2.83650995
82	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.83071796
83	respiratory chain complex IV assembly (GO:0008535)	2.82724021
84	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.81718248
85	reflex (GO:0060004)	2.79652835
86	inner ear receptor cell development (GO:0060119)	2.78685216
87	positive regulation of heat generation (GO:0031652)	2.78330074
88	response to folic acid (GO:0051593)	2.76904735
89	photoreceptor cell maintenance (GO:0045494)	2.76686008
90	regulation of thymocyte apoptotic process (GO:0070243)	2.76397859
91	cAMP metabolic process (GO:0046058)	2.75945163
92	protein localization to synapse (GO:0035418)	2.71196879
93	cellular biogenic amine catabolic process (GO:0042402)	2.71066548
94	amine catabolic process (GO:0009310)	2.71066548
95	termination of RNA polymerase III transcription (GO:0006386)	2.67924442
96	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.67924442
97	regulation of immunoglobulin secretion (GO:0051023)	2.65597500
98	regulation of megakaryocyte differentiation (GO:0045652)	2.63392162
99	respiratory electron transport chain (GO:0022904)	2.62331524
100	electron transport chain (GO:0022900)	2.60978789

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.87796138
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.67819404
3	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	3.57132426
4	VDR_22108803_ChIP-Seq_LS180_Human	2.96115868
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.68113874
6	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.58804452
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.55529264
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.46319735
9	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.39641539
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.36418339
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.22042418
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.14483785
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.13963819
14	REST_21632747_ChIP-Seq_MESCs_Mouse	2.08053003
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.03907151
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.03194304
17	FUS_26573619_Chip-Seq_HEK293_Human	1.98700162
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.89661753
19	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.86690495
20	TP53_22573176_ChIP-Seq_HFKS_Human	1.81523904
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.81321904
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.77636157
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.71412504
24	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.67335669
25	EWS_26573619_Chip-Seq_HEK293_Human	1.66241131
26	P300_19829295_ChIP-Seq_ESCs_Human	1.65559972
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.65509028
28	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.65212215
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.62932007
30	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.56911431
31	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.55333023
32	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.54084328
33	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.51302011
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.50024470
35	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50024470
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49248743
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49231440
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.44096636
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43041439
40	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.42820168
41	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.42231233
42	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.37003457
43	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33840038
44	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.31727989
45	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.30198809
46	RXR_22108803_ChIP-Seq_LS180_Human	1.28795210
47	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.27776076
48	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26651030
49	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.26383577
50	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.24578372
51	AR_21572438_ChIP-Seq_LNCaP_Human	1.20986768
52	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.20690884
53	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.20531859
54	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19992573
55	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18734574
56	MYC_19829295_ChIP-Seq_ESCs_Human	1.18602561
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.18576718
58	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.18332486
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.18298864
60	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.17599805
61	TCF4_23295773_ChIP-Seq_U87_Human	1.17028627
62	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.16353330
63	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.16323593
64	BCAT_22108803_ChIP-Seq_LS180_Human	1.15750577
65	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.12173096
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10860116
67	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10860116
68	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.10724489
69	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.09937723
70	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.09814778
71	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.09542689
72	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.08824118
73	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08605668
74	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.07653733
75	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.07281172
76	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.06786569
77	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.06526428
78	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06270062
79	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.05793933
80	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.04346652
81	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.04249546
82	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04080089
83	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01714692
84	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.00232902
85	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.00074175
86	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.99466337
87	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.98848322
88	STAT3_23295773_ChIP-Seq_U87_Human	0.98577796
89	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.98340467
90	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.97880415
91	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97131709
92	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96313971
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95578241
94	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.95378759
95	JUN_21703547_ChIP-Seq_K562_Human	0.94847817
96	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.94556387
97	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.94476870
98	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.94476870
99	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.94287082
100	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.93845211

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005423_abnormal_somatic_nervous	4.87550076
2	MP0002736_abnormal_nociception_after	3.72913817
3	MP0003880_abnormal_central_pattern	3.46099912
4	MP0003123_paternal_imprinting	3.43242832
5	MP0001968_abnormal_touch/_nociception	3.25248634
6	MP0005646_abnormal_pituitary_gland	2.95273052
7	MP0003787_abnormal_imprinting	2.90136802
8	MP0004742_abnormal_vestibular_system	2.67647164
9	MP0008877_abnormal_DNA_methylation	2.60070490
10	MP0001986_abnormal_taste_sensitivity	2.53159316
11	MP0009379_abnormal_foot_pigmentation	2.50556691
12	MP0000750_abnormal_muscle_regeneration	2.42625991
13	MP0003329_amyloid_beta_deposits	2.32440743
14	MP0003890_abnormal_embryonic-extraembry	2.03333336
15	MP0003806_abnormal_nucleotide_metabolis	1.96381571
16	MP0000631_abnormal_neuroendocrine_gland	1.94699438
17	MP0002272_abnormal_nervous_system	1.92866041
18	MP0002735_abnormal_chemical_nociception	1.92667128
19	MP0006292_abnormal_olfactory_placode	1.82125970
20	MP0003121_genomic_imprinting	1.76315078
21	MP0005551_abnormal_eye_electrophysiolog	1.72830306
22	MP0006276_abnormal_autonomic_nervous	1.64134882
23	MP0008875_abnormal_xenobiotic_pharmacok	1.56131343
24	MP0001440_abnormal_grooming_behavior	1.52862269
25	MP0008789_abnormal_olfactory_epithelium	1.51388738
26	MP0000955_abnormal_spinal_cord	1.46458442
27	MP0002229_neurodegeneration	1.46129133
28	MP0003315_abnormal_perineum_morphology	1.45391616
29	MP0009046_muscle_twitch	1.43502374
30	MP0003635_abnormal_synaptic_transmissio	1.41847531
31	MP0003195_calcinosis	1.39390432
32	MP0001984_abnormal_olfaction	1.39213085
33	MP0004147_increased_porphyrin_level	1.36732686
34	MP0001486_abnormal_startle_reflex	1.36636128
35	MP0000569_abnormal_digit_pigmentation	1.36284077
36	MP0005645_abnormal_hypothalamus_physiol	1.35755142
37	MP0009745_abnormal_behavioral_response	1.35694848
38	MP0002067_abnormal_sensory_capabilities	1.34002413
39	MP0003693_abnormal_embryo_hatching	1.33353588
40	MP0005187_abnormal_penis_morphology	1.32663213
41	MP0002557_abnormal_social/conspecific_i	1.28411063
42	MP0004142_abnormal_muscle_tone	1.27829939
43	MP0003633_abnormal_nervous_system	1.27446940
44	MP0005389_reproductive_system_phenotype	1.23584282
45	MP0003646_muscle_fatigue	1.23239911
46	MP0001970_abnormal_pain_threshold	1.22708936
47	MP0003718_maternal_effect	1.22476800
48	MP0001919_abnormal_reproductive_system	1.20671942
49	MP0002277_abnormal_respiratory_mucosa	1.18752683
50	MP0004885_abnormal_endolymph	1.18440337
51	MP0005394_taste/olfaction_phenotype	1.17171421
52	MP0005499_abnormal_olfactory_system	1.17171421
53	MP0002160_abnormal_reproductive_system	1.15831653
54	MP0004145_abnormal_muscle_electrophysio	1.14651964
55	MP0002734_abnormal_mechanical_nocicepti	1.12066051
56	MP0002064_seizures	1.10160269
57	MP0008872_abnormal_physiological_respon	1.08497349
58	MP0000604_amyloidosis	1.08418979
59	MP0002184_abnormal_innervation	1.08389798
60	MP0002063_abnormal_learning/memory/cond	1.07232245
61	MP0002095_abnormal_skin_pigmentation	1.06528738
62	MP0002876_abnormal_thyroid_physiology	1.06512367
63	MP0000685_abnormal_immune_system	1.05857104
64	MP0001293_anophthalmia	1.05628295
65	MP0002752_abnormal_somatic_nervous	1.04205643
66	MP0001727_abnormal_embryo_implantation	1.01131221
67	MP0000026_abnormal_inner_ear	0.99752591
68	MP0002733_abnormal_thermal_nociception	0.99497202
69	MP0000778_abnormal_nervous_system	0.99170987
70	MP0002572_abnormal_emotion/affect_behav	0.95448950
71	MP0003186_abnormal_redox_activity	0.94730494
72	MP0003632_abnormal_nervous_system	0.93954193
73	MP0003631_nervous_system_phenotype	0.92998144
74	MP0005195_abnormal_posterior_eye	0.92223411
75	MP0006072_abnormal_retinal_apoptosis	0.90828156
76	MP0001485_abnormal_pinna_reflex	0.90674221
77	MP0002882_abnormal_neuron_morphology	0.88572210
78	MP0001963_abnormal_hearing_physiology	0.88500942
79	MP0005377_hearing/vestibular/ear_phenot	0.84776846
80	MP0003878_abnormal_ear_physiology	0.84776846
81	MP0002102_abnormal_ear_morphology	0.84583891
82	MP0004134_abnormal_chest_morphology	0.84484788
83	MP0003943_abnormal_hepatobiliary_system	0.83977949
84	MP0004811_abnormal_neuron_physiology	0.80513389
85	MP0000015_abnormal_ear_pigmentation	0.79760062
86	MP0002837_dystrophic_cardiac_calcinosis	0.78547490
87	MP0005410_abnormal_fertilization	0.78036432
88	MP0000049_abnormal_middle_ear	0.77953126
89	MP0003879_abnormal_hair_cell	0.77369776
90	MP0002163_abnormal_gland_morphology	0.77113449
91	MP0005174_abnormal_tail_pigmentation	0.76041435
92	MP0002210_abnormal_sex_determination	0.73614421
93	MP0000566_synostosis	0.71734962
94	MP0002254_reproductive_system_inflammat	0.71587593
95	MP0004130_abnormal_muscle_cell	0.68334600
96	MP0001529_abnormal_vocalization	0.67264860
97	MP0003936_abnormal_reproductive_system	0.63091034
98	MP0002138_abnormal_hepatobiliary_system	0.62932521
99	MP0002938_white_spotting	0.62714782
100	MP0001835_abnormal_antigen_presentation	0.62560140

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	5.19097511
2	Hyperventilation (HP:0002883)	4.95127744
3	Megalencephaly (HP:0001355)	4.91488154
4	Pendular nystagmus (HP:0012043)	4.68523620
5	Pancreatic cysts (HP:0001737)	4.26966397
6	Congenital sensorineural hearing impairment (HP:0008527)	3.97709555
7	Stomach cancer (HP:0012126)	3.83806173
8	Shawl scrotum (HP:0000049)	3.66437337
9	Progressive macrocephaly (HP:0004481)	3.47710623
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.47420335
11	Pancreatic fibrosis (HP:0100732)	3.46877916
12	Abnormality of midbrain morphology (HP:0002418)	3.44937990
13	Molar tooth sign on MRI (HP:0002419)	3.44937990
14	Nephronophthisis (HP:0000090)	3.32934998
15	Acute necrotizing encephalopathy (HP:0006965)	3.28161611
16	Abnormal number of erythroid precursors (HP:0012131)	3.18338585
17	Septo-optic dysplasia (HP:0100842)	3.10943647
18	Stenosis of the external auditory canal (HP:0000402)	3.05893800
19	Increased IgM level (HP:0003496)	2.99705581
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.90957590
21	Acute encephalopathy (HP:0006846)	2.83230129
22	Chronic hepatic failure (HP:0100626)	2.81989003
23	True hermaphroditism (HP:0010459)	2.79710220
24	Abnormality of the renal medulla (HP:0100957)	2.77614791
25	3-Methylglutaconic aciduria (HP:0003535)	2.63389246
26	Cystic liver disease (HP:0006706)	2.60685786
27	Congenital, generalized hypertrichosis (HP:0004540)	2.59027626
28	Progressive cerebellar ataxia (HP:0002073)	2.57646716
29	Sclerocornea (HP:0000647)	2.48459792
30	Hemiplegia (HP:0002301)	2.47652194
31	Tubular atrophy (HP:0000092)	2.47000962
32	Thyroid-stimulating hormone excess (HP:0002925)	2.41403175
33	Mitochondrial inheritance (HP:0001427)	2.40068544
34	Abnormality of the septum pellucidum (HP:0007375)	2.36910264
35	Broad-based gait (HP:0002136)	2.33898858
36	Asplenia (HP:0001746)	2.33319069
37	Abnormality of the axillary hair (HP:0100134)	2.30343096
38	Abnormality of secondary sexual hair (HP:0009888)	2.30343096
39	Congenital stationary night blindness (HP:0007642)	2.29815468
40	Increased CSF lactate (HP:0002490)	2.29381685
41	Absent speech (HP:0001344)	2.28964631
42	Optic disc pallor (HP:0000543)	2.26638878
43	Thickened helices (HP:0000391)	2.24820626
44	Male pseudohermaphroditism (HP:0000037)	2.21346659
45	Hypogonadotrophic hypogonadism (HP:0000044)	2.19719189
46	Spontaneous abortion (HP:0005268)	2.19233083
47	Macrocytic anemia (HP:0001972)	2.18636663
48	Amyotrophic lateral sclerosis (HP:0007354)	2.17262338
49	Hypothermia (HP:0002045)	2.17025741
50	Medial flaring of the eyebrow (HP:0010747)	2.15690451
51	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.12926225
52	Hemiparesis (HP:0001269)	2.11984699
53	Type II lissencephaly (HP:0007260)	2.11711521
54	Abnormality of macular pigmentation (HP:0008002)	2.11245648
55	Tubulointerstitial fibrosis (HP:0005576)	2.09724598
56	Severe visual impairment (HP:0001141)	2.09152202
57	Rib fusion (HP:0000902)	2.08467119
58	Poor eye contact (HP:0000817)	2.06635806
59	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.04738113
60	Myokymia (HP:0002411)	2.04281055
61	Abolished electroretinogram (ERG) (HP:0000550)	1.98990829
62	Decreased circulating renin level (HP:0003351)	1.97895374
63	Furrowed tongue (HP:0000221)	1.97612389
64	Cerebral edema (HP:0002181)	1.97447255
65	Bony spicule pigmentary retinopathy (HP:0007737)	1.97398650
66	Protruding tongue (HP:0010808)	1.96203059
67	Severe Myopia (HP:0011003)	1.96018235
68	Lipid accumulation in hepatocytes (HP:0006561)	1.95925399
69	IgG deficiency (HP:0004315)	1.94438018
70	Absent septum pellucidum (HP:0001331)	1.89916959
71	Cupped ear (HP:0000378)	1.86726373
72	Abnormality of the renal cortex (HP:0011035)	1.85693423
73	Anosmia (HP:0000458)	1.82873819
74	Chronic bronchitis (HP:0004469)	1.82328149
75	Tented upper lip vermilion (HP:0010804)	1.82315378
76	Abnormal rod and cone electroretinograms (HP:0008323)	1.81340442
77	Increased hepatocellular lipid droplets (HP:0006565)	1.81019680
78	Capillary hemangiomas (HP:0005306)	1.79748226
79	Dyskinesia (HP:0100660)	1.79739141
80	Truncal obesity (HP:0001956)	1.79213125
81	Retinal dysplasia (HP:0007973)	1.78708123
82	Abnormality of the labia minora (HP:0012880)	1.77962010
83	Adrenal hypoplasia (HP:0000835)	1.76729845
84	Alveolar cell carcinoma (HP:0006519)	1.75949608
85	Polymicrogyria (HP:0002126)	1.75527907
86	Abnormality of the aortic arch (HP:0012303)	1.75523806
87	Abnormality of the diencephalon (HP:0010662)	1.74750822
88	Aplasia/hypoplasia of the uterus (HP:0008684)	1.72976526
89	Hypoplasia of the brainstem (HP:0002365)	1.72547496
90	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.72547496
91	Colon cancer (HP:0003003)	1.72541005
92	Increased serum lactate (HP:0002151)	1.72029185
93	Abnormal drinking behavior (HP:0030082)	1.71844673
94	Polydipsia (HP:0001959)	1.71844673
95	Hypoplasia of the uterus (HP:0000013)	1.71430221
96	Entropion (HP:0000621)	1.70534686
97	Parakeratosis (HP:0001036)	1.70412200
98	Attenuation of retinal blood vessels (HP:0007843)	1.69321636
99	Intellectual disability, progressive (HP:0006887)	1.68891680
100	Tinnitus (HP:0000360)	1.68569874

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	DYRK2	4.21315661
2	NUAK1	3.00663015
3	TNIK	2.94404027
4	MAP3K13	2.70219993
5	LATS1	2.39009813
6	MST4	2.34395373
7	STK16	2.32103039
8	GRK1	2.31788670
9	ZAK	2.30459874
10	CASK	2.27735246
11	MAP4K2	2.25582654
12	ADRBK2	2.15369081
13	AKT3	2.15206333
14	FGFR1	2.06478826
15	WNK4	2.04889823
16	FRK	1.98301834
17	HIPK2	1.98230001
18	MARK1	1.95586155
19	PNCK	1.80175627
20	TAOK3	1.72239645
21	PRKCZ	1.66652542
22	INSRR	1.63927472
23	TIE1	1.62979321
24	CSNK1G1	1.56469548
25	MINK1	1.47202312
26	CHUK	1.43475466
27	PRKCG	1.33652702
28	NME1	1.30582445
29	PAK3	1.30303385
30	STK39	1.26420624
31	CSNK1A1L	1.26373024
32	IKBKB	1.26092618
33	SGK223	1.26046419
34	SGK494	1.26046419
35	VRK2	1.23382435
36	ADRBK1	1.20403171
37	CSNK1G2	1.08831161
38	GRK7	0.98684743
39	SGK2	0.97018667
40	ITK	0.93634059
41	KSR1	0.93233023
42	VRK1	0.89150198
43	CSNK1G3	0.86444915
44	PRKCI	0.86270381
45	MAP3K7	0.86088794
46	MARK3	0.84337778
47	OXSR1	0.84256030
48	DYRK1A	0.81019673
49	SRPK1	0.80619570
50	RPS6KA5	0.79493268
51	SGK1	0.78137824
52	MKNK2	0.77306568
53	PIK3CA	0.75517137
54	PHKG1	0.75161177
55	PHKG2	0.75161177
56	MAPK13	0.74412354
57	TEC	0.73876460
58	EPHA4	0.73225497
59	PRKCE	0.72316761
60	STK3	0.71458740
61	CSNK1E	0.70949241
62	PRKCH	0.70909768
63	GRK5	0.67132642
64	STK4	0.66458563
65	PDK2	0.65337578
66	MYLK	0.64875630
67	TXK	0.64861170
68	TLK1	0.63493175
69	PRKCQ	0.63101327
70	BMPR1B	0.61856754
71	BTK	0.61759165
72	MAP3K14	0.61680016
73	PRKAA2	0.56584063
74	SGK3	0.56492842
75	LYN	0.56220224
76	CSNK1A1	0.53641151
77	PLK3	0.52321188
78	PRKG1	0.52020211
79	PRKACA	0.51772235
80	AURKB	0.50729204
81	WNK1	0.49354242
82	PRKCB	0.48993013
83	PRKCA	0.48092930
84	ABL2	0.47946222
85	PIM1	0.47479394
86	PTK6	0.46608359
87	IRAK1	0.46228508
88	MAP3K12	0.45140269
89	PRKCD	0.45038208
90	WNK3	0.41420358
91	CAMK2A	0.38962415
92	PRKDC	0.38217778
93	PRKACG	0.37273661
94	PLK1	0.36127732
95	MAP4K1	0.35477418
96	EIF2AK2	0.35369868
97	OBSCN	0.34360899
98	CSNK2A2	0.33903204
99	PRKD3	0.33164922
100	CAMK2G	0.33111905

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.50480995
2	Ribosome_Homo sapiens_hsa03010	3.41949371
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.20865709
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.64260865
5	Parkinsons disease_Homo sapiens_hsa05012	2.50092658
6	Nicotine addiction_Homo sapiens_hsa05033	2.44538495
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.29163130
8	Caffeine metabolism_Homo sapiens_hsa00232	2.26074226
9	Morphine addiction_Homo sapiens_hsa05032	2.22815625
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.18621433
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.17937111
12	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.15866510
13	Ether lipid metabolism_Homo sapiens_hsa00565	2.13872763
14	RNA polymerase_Homo sapiens_hsa03020	2.12167996
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.07918769
16	Protein export_Homo sapiens_hsa03060	2.07305053
17	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.96352488
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.82439159
19	Huntingtons disease_Homo sapiens_hsa05016	1.77428460
20	Glutamatergic synapse_Homo sapiens_hsa04724	1.74368557
21	Alzheimers disease_Homo sapiens_hsa05010	1.73439055
22	Phototransduction_Homo sapiens_hsa04744	1.72721179
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.63277295
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.59624238
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.58208093
26	One carbon pool by folate_Homo sapiens_hsa00670	1.51598993
27	Proteasome_Homo sapiens_hsa03050	1.50876066
28	Spliceosome_Homo sapiens_hsa03040	1.41519505
29	Glutathione metabolism_Homo sapiens_hsa00480	1.38717139
30	Asthma_Homo sapiens_hsa05310	1.20442561
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.20169492
32	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.15710884
33	RNA transport_Homo sapiens_hsa03013	1.14845780
34	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.09478987
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.08310586
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.06838562
37	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.06450921
38	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.06044201
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.05996793
40	GABAergic synapse_Homo sapiens_hsa04727	1.04002945
41	Butanoate metabolism_Homo sapiens_hsa00650	1.03453931
42	Basal transcription factors_Homo sapiens_hsa03022	1.02100805
43	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.01473901
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.98801817
45	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.98238727
46	Propanoate metabolism_Homo sapiens_hsa00640	0.97642278
47	Circadian entrainment_Homo sapiens_hsa04713	0.96805372
48	Insulin secretion_Homo sapiens_hsa04911	0.87057454
49	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.86917347
50	Retinol metabolism_Homo sapiens_hsa00830	0.86889433
51	Purine metabolism_Homo sapiens_hsa00230	0.86566996
52	Sulfur relay system_Homo sapiens_hsa04122	0.86313461
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.84427445
54	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.84138073
55	RNA degradation_Homo sapiens_hsa03018	0.81727982
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.77284742
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74636054
58	Histidine metabolism_Homo sapiens_hsa00340	0.73569058
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.68631080
60	Olfactory transduction_Homo sapiens_hsa04740	0.67672856
61	Tryptophan metabolism_Homo sapiens_hsa00380	0.67275173
62	Serotonergic synapse_Homo sapiens_hsa04726	0.66409543
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.65139891
64	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.64035456
65	Cholinergic synapse_Homo sapiens_hsa04725	0.62304043
66	Salivary secretion_Homo sapiens_hsa04970	0.62080129
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60321349
68	cAMP signaling pathway_Homo sapiens_hsa04024	0.58366007
69	Gastric acid secretion_Homo sapiens_hsa04971	0.58260081
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56448642
71	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.55848273
72	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.55117355
73	Homologous recombination_Homo sapiens_hsa03440	0.53962328
74	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53352665
75	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.52521962
76	Allograft rejection_Homo sapiens_hsa05330	0.50402870
77	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.50055906
78	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.48952715
79	Dopaminergic synapse_Homo sapiens_hsa04728	0.48033612
80	Metabolic pathways_Homo sapiens_hsa01100	0.47274111
81	Amphetamine addiction_Homo sapiens_hsa05031	0.46739295
82	Peroxisome_Homo sapiens_hsa04146	0.45766030
83	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.45110603
84	Ras signaling pathway_Homo sapiens_hsa04014	0.43279513
85	Cocaine addiction_Homo sapiens_hsa05030	0.39934825
86	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.39611969
87	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.38809224
88	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.37754041
89	Fatty acid degradation_Homo sapiens_hsa00071	0.37576808
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36002161
91	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35567580
92	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.33974380
93	Steroid biosynthesis_Homo sapiens_hsa00100	0.33578678
94	Mineral absorption_Homo sapiens_hsa04978	0.33497438
95	Pyrimidine metabolism_Homo sapiens_hsa00240	0.32541687
96	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.31894438
97	Pancreatic secretion_Homo sapiens_hsa04972	0.30894694
98	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.30366850
99	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29698403
100	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.29333454

RPL35AP26

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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