RPL35AP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)8.23026989
2regulation of immunoglobulin secretion (GO:0051023)7.74016461
3positive regulation of macrophage activation (GO:0043032)6.95627799
4L-methionine biosynthetic process from methylthioadenosine (GO:0019509)6.46729782
5regulation of interleukin-13 production (GO:0032656)6.14988568
6positive regulation of chemokine secretion (GO:0090197)5.98669382
7negative regulation of cAMP-mediated signaling (GO:0043951)5.59095526
8L-methionine salvage (GO:0071267)5.40178650
9L-methionine biosynthetic process (GO:0071265)5.40178650
10amino acid salvage (GO:0043102)5.40178650
11regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.33739041
12microtubule nucleation (GO:0007020)5.32029981
13response to pheromone (GO:0019236)5.30921890
14regulation of chemokine secretion (GO:0090196)5.30829471
15atrial cardiac muscle cell action potential (GO:0086014)5.18700482
16base-excision repair, AP site formation (GO:0006285)5.15873342
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.04151628
18regulation of translation in response to stress (GO:0043555)4.94232054
19ER overload response (GO:0006983)4.88838732
20regulation of meiosis I (GO:0060631)4.79238177
21response to folic acid (GO:0051593)4.71061727
22primitive streak formation (GO:0090009)4.70924123
23toxin transport (GO:1901998)4.55532789
24embryonic retina morphogenesis in camera-type eye (GO:0060059)4.38148703
25secretory granule organization (GO:0033363)4.32262265
26single strand break repair (GO:0000012)4.24143962
27amino-acid betaine metabolic process (GO:0006577)4.20071383
28purine deoxyribonucleotide catabolic process (GO:0009155)4.16267928
29ribosomal small subunit assembly (GO:0000028)4.12911995
30methionine biosynthetic process (GO:0009086)4.08815521
31cell migration involved in gastrulation (GO:0042074)4.07483914
32centriole replication (GO:0007099)4.05673555
33peptidyl-glutamic acid carboxylation (GO:0017187)3.97055298
34protein carboxylation (GO:0018214)3.97055298
35positive regulation of type 2 immune response (GO:0002830)3.96328727
36regulation of macrophage activation (GO:0043030)3.90724735
37lysosome localization (GO:0032418)3.76365262
38negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.66743851
39platelet dense granule organization (GO:0060155)3.62477830
40otic vesicle formation (GO:0030916)3.47428169
41cellular response to cholesterol (GO:0071397)3.44275067
42CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.43390093
43positive regulation of interleukin-4 production (GO:0032753)3.42258494
44cellular response to sterol (GO:0036315)3.39531059
45positive regulation of immunoglobulin production (GO:0002639)3.39113113
46regulation of non-canonical Wnt signaling pathway (GO:2000050)3.38067630
47head development (GO:0060322)3.37887927
48GMP metabolic process (GO:0046037)3.37848105
49methionine metabolic process (GO:0006555)3.27278524
50aspartate family amino acid biosynthetic process (GO:0009067)3.24778664
51deoxyribonucleotide catabolic process (GO:0009264)3.21709200
52negative regulation of JAK-STAT cascade (GO:0046426)3.20032662
53cell wall macromolecule catabolic process (GO:0016998)3.19292605
54negative regulation of leukocyte migration (GO:0002686)3.17104023
55radial glial cell differentiation (GO:0060019)3.16074217
56arginine catabolic process (GO:0006527)3.13568607
57positive regulation of meiosis (GO:0045836)3.13253020
58deoxyribose phosphate catabolic process (GO:0046386)3.09656741
59phosphatidylinositol phosphorylation (GO:0046854)3.08504645
60regulation of interleukin-5 production (GO:0032674)3.07134162
61negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.05687318
62regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.04327918
63regulation of mesenchymal cell apoptotic process (GO:2001053)3.00075153
64retinoic acid metabolic process (GO:0042573)2.99458860
65regulation of immunoglobulin production (GO:0002637)2.96812450
66detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.96411270
67regulation of phospholipase A2 activity (GO:0032429)2.94859681
68pyrimidine dimer repair (GO:0006290)2.93004803
69histone mRNA catabolic process (GO:0071044)2.92952419
70positive regulation of DNA recombination (GO:0045911)2.90968590
71positive regulation of meiotic cell cycle (GO:0051446)2.90418838
72embryonic viscerocranium morphogenesis (GO:0048703)2.89659447
73ventricular cardiac muscle cell action potential (GO:0086005)2.82507901
74regulation of heart rate by cardiac conduction (GO:0086091)2.82503977
75postreplication repair (GO:0006301)2.81129635
76cartilage morphogenesis (GO:0060536)2.80763908
77endoderm formation (GO:0001706)2.80485285
78rRNA catabolic process (GO:0016075)2.79590232
79dopamine transport (GO:0015872)2.79100015
80lipid phosphorylation (GO:0046834)2.78800204
81neuroblast proliferation (GO:0007405)2.77999533
82regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.76082097
83dopaminergic neuron differentiation (GO:0071542)2.75082364
84negative regulation of adaptive immune response (GO:0002820)2.75000139
85renal tubule morphogenesis (GO:0061333)2.74711060
86protein complex biogenesis (GO:0070271)2.71785347
87cellular response to ATP (GO:0071318)2.70903966
88sulfur amino acid biosynthetic process (GO:0000097)2.70744370
89protein heterotrimerization (GO:0070208)2.69649806
90genitalia morphogenesis (GO:0035112)2.66850833
91DNA demethylation (GO:0080111)2.66762712
92cell wall macromolecule metabolic process (GO:0044036)2.65082369
93positive regulation of heart rate (GO:0010460)2.63376974
94mitochondrial respiratory chain complex I assembly (GO:0032981)2.62878002
95NADH dehydrogenase complex assembly (GO:0010257)2.62878002
96mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.62878002
97cardiovascular system development (GO:0072358)2.62837194
98negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61099629
99regulation of smooth muscle cell apoptotic process (GO:0034391)2.58792397
100regulation of T-helper 1 type immune response (GO:0002825)2.58632425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.85800156
2CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.31459796
3IRF1_19129219_ChIP-ChIP_H3396_Human3.23289898
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.21432569
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.99830279
6MYC_18940864_ChIP-ChIP_HL60_Human2.61804684
7ZNF274_21170338_ChIP-Seq_K562_Hela2.33357100
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.31994739
9GBX2_23144817_ChIP-Seq_PC3_Human2.22296707
10PCGF2_27294783_Chip-Seq_NPCs_Mouse2.07858768
11VDR_22108803_ChIP-Seq_LS180_Human2.07562044
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05173920
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01720382
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00314535
15GATA1_26923725_Chip-Seq_HPCs_Mouse1.94517343
16GATA1_22025678_ChIP-Seq_K562_Human1.86658607
17MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.86032072
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.79629246
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75077404
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71607866
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71037795
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64745233
23EWS_26573619_Chip-Seq_HEK293_Human1.63900212
24TP53_22573176_ChIP-Seq_HFKS_Human1.63378570
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51748582
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47192348
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.44618407
28BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37364790
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.37358647
30GATA3_21878914_ChIP-Seq_MCF-7_Human1.36685273
31EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.35069890
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32959782
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.32829160
34RARB_24833708_ChIP-Seq_LIVER_Mouse1.32345289
35ETV1_20927104_ChIP-Seq_GIST48_Human1.31394733
36ERA_21632823_ChIP-Seq_H3396_Human1.30805756
37REST_21632747_ChIP-Seq_MESCs_Mouse1.30040888
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29071900
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28966833
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.28657511
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27161952
42CBP_20019798_ChIP-Seq_JUKART_Human1.27161952
43GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27056528
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24369213
45SMAD4_21799915_ChIP-Seq_A2780_Human1.23721110
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.22216205
47FOXP3_21729870_ChIP-Seq_TREG_Human1.22051266
48NCOR_22424771_ChIP-Seq_293T_Human1.21331921
49CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.21044875
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.20462962
51ER_23166858_ChIP-Seq_MCF-7_Human1.17482645
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.15665923
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15665923
54KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15569111
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15496036
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15496036
57PRDM14_20953172_ChIP-Seq_ESCs_Human1.15070561
58OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14451652
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12365831
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10589784
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.09496333
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08670272
63SMAD4_21741376_ChIP-Seq_EPCs_Human1.07630918
64CTCF_20526341_ChIP-Seq_ESCs_Human1.07552089
65GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.07010268
66PHF8_20622853_ChIP-Seq_HELA_Human1.06556226
67KAP1_22055183_ChIP-Seq_ESCs_Mouse1.05991080
68FUS_26573619_Chip-Seq_HEK293_Human1.05666474
69WDR5_24793694_ChIP-Seq_LNCAP_Human1.05504493
70NANOG_20526341_ChIP-Seq_ESCs_Human1.05296210
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04715244
72RNF2_27304074_Chip-Seq_NSC_Mouse1.03884642
73STAT3_18555785_Chip-Seq_ESCs_Mouse1.03667565
74MYC_19829295_ChIP-Seq_ESCs_Human1.03507788
75P53_21459846_ChIP-Seq_SAOS-2_Human1.03470089
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02380806
77CBX2_22325352_ChIP-Seq_293T-Rex_Human1.02294508
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.01992973
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01892989
80VDR_23849224_ChIP-Seq_CD4+_Human1.01860952
81GABP_19822575_ChIP-Seq_HepG2_Human1.01506213
82P300_19829295_ChIP-Seq_ESCs_Human1.01412960
83TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01270239
84TCF4_23295773_ChIP-Seq_U87_Human1.00927696
85NFYB_21822215_ChIP-Seq_K562_Human1.00414787
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.00238724
87CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.99612027
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99305369
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98877053
90KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98743082
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98640803
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98460110
93SMAD3_21741376_ChIP-Seq_EPCs_Human0.98042905
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98023931
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97275522
96STAT3_23295773_ChIP-Seq_U87_Human0.96454876
97RBPJ_21746931_ChIP-Seq_IB4_Human0.96219617
98HOXB7_26014856_ChIP-Seq_BT474_Human0.96067187
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.96026409
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95943923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004885_abnormal_endolymph6.35164787
2MP0003283_abnormal_digestive_organ4.81817910
3MP0006292_abnormal_olfactory_placode3.85854527
4MP0004742_abnormal_vestibular_system3.14332634
5MP0001440_abnormal_grooming_behavior2.61552194
6MP0003122_maternal_imprinting2.54034099
7MP0000015_abnormal_ear_pigmentation2.52285808
8MP0005075_abnormal_melanosome_morpholog2.41989431
9MP0002653_abnormal_ependyma_morphology2.25777449
10MP0002132_abnormal_respiratory_system2.25425418
11MP0002735_abnormal_chemical_nociception2.19586222
12MP0001485_abnormal_pinna_reflex2.13697072
13MP0002254_reproductive_system_inflammat2.12534346
14MP0003890_abnormal_embryonic-extraembry2.07643215
15MP0008877_abnormal_DNA_methylation2.06693962
16MP0000049_abnormal_middle_ear1.90208107
17MP0001984_abnormal_olfaction1.89254051
18MP0006035_abnormal_mitochondrial_morpho1.88789919
19MP0008875_abnormal_xenobiotic_pharmacok1.87098906
20MP0004133_heterotaxia1.82216543
21MP0002095_abnormal_skin_pigmentation1.75422538
22MP0000566_synostosis1.72668345
23MP0003567_abnormal_fetal_cardiomyocyte1.71441159
24MP0005551_abnormal_eye_electrophysiolog1.65330167
25MP0002736_abnormal_nociception_after1.55395200
26MP0008872_abnormal_physiological_respon1.54379752
27MP0001968_abnormal_touch/_nociception1.48450211
28MP0006036_abnormal_mitochondrial_physio1.43344461
29MP0001727_abnormal_embryo_implantation1.37867235
30MP0000631_abnormal_neuroendocrine_gland1.36473537
31MP0001986_abnormal_taste_sensitivity1.35120393
32MP0008995_early_reproductive_senescence1.31405467
33MP0003121_genomic_imprinting1.30828173
34MP0002938_white_spotting1.30370639
35MP0006276_abnormal_autonomic_nervous1.29569343
36MP0004142_abnormal_muscle_tone1.29188877
37MP0005646_abnormal_pituitary_gland1.25933237
38MP0002557_abnormal_social/conspecific_i1.25683950
39MP0009764_decreased_sensitivity_to1.25148518
40MP0008789_abnormal_olfactory_epithelium1.24687268
41MP0002272_abnormal_nervous_system1.20163490
42MP0000026_abnormal_inner_ear1.20035561
43MP0001293_anophthalmia1.16932855
44MP0005084_abnormal_gallbladder_morpholo1.12229222
45MP0003646_muscle_fatigue1.10854339
46MP0006072_abnormal_retinal_apoptosis1.09710186
47MP0001963_abnormal_hearing_physiology1.09476175
48MP0002638_abnormal_pupillary_reflex1.08206307
49MP0003880_abnormal_central_pattern1.07698210
50MP0002837_dystrophic_cardiac_calcinosis1.05267364
51MP0002177_abnormal_outer_ear1.02195146
52MP0002102_abnormal_ear_morphology1.01964661
53MP0003635_abnormal_synaptic_transmissio0.97182092
54MP0004145_abnormal_muscle_electrophysio0.95407344
55MP0000678_abnormal_parathyroid_gland0.95049597
56MP0003878_abnormal_ear_physiology0.94143425
57MP0005377_hearing/vestibular/ear_phenot0.94143425
58MP0005195_abnormal_posterior_eye0.93814418
59MP0001502_abnormal_circadian_rhythm0.92789313
60MP0004811_abnormal_neuron_physiology0.92456170
61MP0004859_abnormal_synaptic_plasticity0.92141531
62MP0002234_abnormal_pharynx_morphology0.91664822
63MP0001188_hyperpigmentation0.90360556
64MP0003698_abnormal_male_reproductive0.90209211
65MP0003123_paternal_imprinting0.90190456
66MP0009379_abnormal_foot_pigmentation0.89853009
67MP0008775_abnormal_heart_ventricle0.89353882
68MP0004019_abnormal_vitamin_homeostasis0.88510459
69MP0008058_abnormal_DNA_repair0.87932354
70MP0002752_abnormal_somatic_nervous0.86331786
71MP0002063_abnormal_learning/memory/cond0.86326777
72MP0005452_abnormal_adipose_tissue0.84973875
73MP0003195_calcinosis0.84437798
74MP0003252_abnormal_bile_duct0.83323488
75MP0003638_abnormal_response/metabolism_0.82653954
76MP0005394_taste/olfaction_phenotype0.82465792
77MP0005499_abnormal_olfactory_system0.82465792
78MP0005645_abnormal_hypothalamus_physiol0.79941686
79MP0005389_reproductive_system_phenotype0.79518206
80MP0008569_lethality_at_weaning0.79085799
81MP0003787_abnormal_imprinting0.78916916
82MP0002160_abnormal_reproductive_system0.77906149
83MP0009745_abnormal_behavioral_response0.77423559
84MP0001324_abnormal_eye_pigmentation0.76209814
85MP0001764_abnormal_homeostasis0.75888143
86MP0002115_abnormal_skeleton_extremities0.75352411
87MP0003186_abnormal_redox_activity0.74870266
88MP0002009_preneoplasia0.74075825
89MP0003937_abnormal_limbs/digits/tail_de0.72184735
90MP0001765_abnormal_ion_homeostasis0.71852123
91MP0002572_abnormal_emotion/affect_behav0.69256822
92MP0003959_abnormal_lean_body0.67826231
93MP0002282_abnormal_trachea_morphology0.67688459
94MP0001905_abnormal_dopamine_level0.65700821
95MP0001486_abnormal_startle_reflex0.65371090
96MP0002229_neurodegeneration0.63883884
97MP0004043_abnormal_pH_regulation0.63761405
98MP0001270_distended_abdomen0.63427591
99MP0000778_abnormal_nervous_system0.61866622
100MP0002066_abnormal_motor_capabilities/c0.61705428

Predicted human phenotypes

RankGene SetZ-score
1Conjugated hyperbilirubinemia (HP:0002908)5.80708759
2Morphological abnormality of the inner ear (HP:0011390)4.31428279
3Rectal prolapse (HP:0002035)4.28289863
4Cerebral hypomyelination (HP:0006808)4.25442739
5Hip dysplasia (HP:0001385)4.19834106
6Congenital stationary night blindness (HP:0007642)4.12350009
7Entropion (HP:0000621)4.06622357
8Abnormality of the renal cortex (HP:0011035)3.93250169
9Abnormality of the right ventricle (HP:0001707)3.81169403
10Nephrogenic diabetes insipidus (HP:0009806)3.79610086
11Metabolic alkalosis (HP:0200114)3.61342433
12Polyuria (HP:0000103)3.57423184
13Tubulointerstitial fibrosis (HP:0005576)3.31159636
14Arthropathy (HP:0003040)3.26295920
15Renal salt wasting (HP:0000127)3.25090192
16Hypokalemic alkalosis (HP:0001949)3.23627971
17Thickened calvaria (HP:0002684)3.09788337
18Abnormality of the renal medulla (HP:0100957)3.07788296
19Morphological abnormality of the middle ear (HP:0008609)3.06777081
20Poikiloderma (HP:0001029)2.93843477
21Abnormality of incisor morphology (HP:0011063)2.92964905
22Abnormality of the labia minora (HP:0012880)2.90856502
23Abnormal urine output (HP:0012590)2.90546239
24Hypoplastic ischia (HP:0003175)2.90412076
25Hypomagnesemia (HP:0002917)2.87753449
26Cutaneous melanoma (HP:0012056)2.85266214
27Abnormality of the nasal septum (HP:0000419)2.84464600
28Dynein arm defect of respiratory motile cilia (HP:0012255)2.80816038
29Absent/shortened dynein arms (HP:0200106)2.80816038
30True hermaphroditism (HP:0010459)2.74159552
31Abnormal rod and cone electroretinograms (HP:0008323)2.73588963
32Squamous cell carcinoma (HP:0002860)2.66918626
33Vitreoretinal degeneration (HP:0000655)2.66370933
34Molar tooth sign on MRI (HP:0002419)2.65097333
35Abnormality of midbrain morphology (HP:0002418)2.65097333
36Oligodactyly (hands) (HP:0001180)2.63155776
37Abnormality of the 4th metacarpal (HP:0010012)2.56452455
38Unsteady gait (HP:0002317)2.53888517
39Pancreatic fibrosis (HP:0100732)2.52948152
40Tubulointerstitial abnormality (HP:0001969)2.41446952
41Abnormality of renal excretion (HP:0011036)2.38057720
42Alkalosis (HP:0001948)2.37828424
43Pancreatic cysts (HP:0001737)2.37750419
44Abnormality of magnesium homeostasis (HP:0004921)2.37363084
45Acute necrotizing encephalopathy (HP:0006965)2.36880701
46Hyponatremia (HP:0002902)2.35058332
47Abnormality of cells of the erythroid lineage (HP:0012130)2.32161380
48Abnormality of the ischium (HP:0003174)2.31703168
49Hepatocellular necrosis (HP:0001404)2.31216052
50CNS demyelination (HP:0007305)2.31147718
51Abnormality of chloride homeostasis (HP:0011422)2.30615397
52Hyperaldosteronism (HP:0000859)2.29533047
53Delusions (HP:0000746)2.29519203
54Aplasia/Hypoplasia of the spleen (HP:0010451)2.29510171
55Hypoplasia of the fovea (HP:0007750)2.29077794
56Aplasia/Hypoplasia of the fovea (HP:0008060)2.29077794
57Hypokalemia (HP:0002900)2.26243953
58Polyphagia (HP:0002591)2.25276109
59Small hand (HP:0200055)2.21384183
60Chorioretinal atrophy (HP:0000533)2.20941970
61Failure to thrive in infancy (HP:0001531)2.19961329
62Long clavicles (HP:0000890)2.19473218
63Mitochondrial inheritance (HP:0001427)2.17824391
64Nephronophthisis (HP:0000090)2.15883344
65Emotional lability (HP:0000712)2.15784370
66Chronic bronchitis (HP:0004469)2.15421961
67Irregular epiphyses (HP:0010582)2.12475040
6811 pairs of ribs (HP:0000878)2.11204894
69Esotropia (HP:0000565)2.10135527
70Decreased subcutaneous fat (HP:0001002)2.08616993
71Abnormal mitochondria in muscle tissue (HP:0008316)2.07882779
72Abnormality of cochlea (HP:0000375)2.07834046
73Increased CSF lactate (HP:0002490)2.07539005
74Shawl scrotum (HP:0000049)2.05889895
75Volvulus (HP:0002580)2.02754539
76Type 2 muscle fiber atrophy (HP:0003554)2.02656801
77Medial flaring of the eyebrow (HP:0010747)1.99422484
78Renal tubular acidosis (HP:0001947)1.98835949
79Fibular hypoplasia (HP:0003038)1.97959444
80Abnormality of DNA repair (HP:0003254)1.96830041
81Narrow forehead (HP:0000341)1.96516438
82Papilledema (HP:0001085)1.95919956
83Lissencephaly (HP:0001339)1.95511713
84Premature ovarian failure (HP:0008209)1.95037289
85Asplenia (HP:0001746)1.94997135
86Oligodactyly (HP:0012165)1.94235374
87Keratoconus (HP:0000563)1.94059329
88Increased corneal curvature (HP:0100692)1.94059329
89Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93175227
90Febrile seizures (HP:0002373)1.91893843
91Short chin (HP:0000331)1.89993607
92Secondary amenorrhea (HP:0000869)1.88339040
93Pendular nystagmus (HP:0012043)1.87593594
94Abnormal EKG (HP:0003115)1.85164358
95Acute encephalopathy (HP:0006846)1.84919207
96Colon cancer (HP:0003003)1.84194960
97Abnormal number of erythroid precursors (HP:0012131)1.83930838
98Hepatic necrosis (HP:0002605)1.83229958
99Abnormality of potassium homeostasis (HP:0011042)1.81617655
100Neoplasm of the peripheral nervous system (HP:0100007)1.81428591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK15.72201135
2LATS14.54348068
3CASK3.59886222
4STK163.12758453
5MAPK122.90020372
6PINK12.85362964
7FGFR32.79706626
8ADRBK22.75092007
9EIF2AK12.15444256
10CDK32.13104641
11MARK32.03788708
12PBK1.98000747
13CCNB11.97075918
14CSNK1G11.86290910
15MAP4K21.84823830
16MAP2K21.75635689
17DAPK21.59732141
18STK41.56853492
19MST41.48974658
20AKT31.40328708
21EPHB21.40018033
22MAP2K61.22235410
23DMPK1.19242940
24BCKDK1.14175651
25NLK1.10986490
26PIM11.08439722
27TEC1.06163263
28PASK1.03318291
29PAK31.02808268
30MAPK131.00433949
31PRKD20.99070779
32FGFR10.94662855
33WNK30.94510770
34PNCK0.94390870
35WNK10.93371168
36INSRR0.93326134
37CDK190.93114158
38STK30.92415889
39TLK10.91256633
40MARK10.90650399
41FRK0.88936557
42WNK40.79960857
43DYRK1B0.77365868
44MAP3K110.75244163
45PHKG10.74422305
46PHKG20.74422305
47BMPR1B0.73223104
48MAP3K90.72127741
49GRK70.70782621
50STK100.70046767
51RPS6KA60.68263546
52MATK0.67541773
53UHMK10.63967218
54PIK3CA0.63362526
55IKBKB0.62957399
56CDC70.61982860
57WEE10.61604578
58TXK0.61554878
59GSK3A0.59644971
60RPS6KB20.57599663
61PRKCH0.54058197
62CSNK1G20.53990340
63MAPK70.53422268
64CAMK10.53256171
65IKBKE0.53008893
66CSNK1G30.52557909
67ITK0.52228508
68SIK30.51184318
69SGK4940.50571366
70SGK2230.50571366
71RPS6KL10.50062817
72RPS6KC10.50062817
73DYRK20.49522266
74KSR10.49058433
75GRK10.48702990
76ADRBK10.47877058
77CSNK1E0.47236190
78PRKCQ0.46018122
79PTK2B0.45733768
80FER0.44759320
81PRKCE0.42931470
82RIPK40.42060105
83AURKB0.41064078
84CSNK1A10.36915971
85MAP3K70.35241100
86KIT0.34964073
87OBSCN0.34845893
88RPS6KA10.33279380
89TAOK30.33166841
90PLK40.33134720
91PRKCI0.33132673
92PRKACA0.32552063
93BRSK20.32344860
94MAPK90.32260183
95CAMK1G0.31990065
96MAPK140.31465871
97DAPK30.31281384
98RPS6KB10.30827180
99OXSR10.30823263
100TGFBR10.30702237

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001307.59553559
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.32133827
3Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.92321665
4Phototransduction_Homo sapiens_hsa047442.82078344
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32149733
6Linoleic acid metabolism_Homo sapiens_hsa005912.30952885
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.28442145
8Base excision repair_Homo sapiens_hsa034102.10795751
9Ribosome_Homo sapiens_hsa030102.10036969
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.06158859
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.03131620
12Fanconi anemia pathway_Homo sapiens_hsa034601.82554897
13Proteasome_Homo sapiens_hsa030501.78666177
14Nitrogen metabolism_Homo sapiens_hsa009101.75362343
15Caffeine metabolism_Homo sapiens_hsa002321.63498097
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59615980
17Oxidative phosphorylation_Homo sapiens_hsa001901.49645802
18One carbon pool by folate_Homo sapiens_hsa006701.42612474
19Parkinsons disease_Homo sapiens_hsa050121.40434993
20Asthma_Homo sapiens_hsa053101.39079663
21Propanoate metabolism_Homo sapiens_hsa006401.37071663
22Long-term depression_Homo sapiens_hsa047301.35195595
23Protein export_Homo sapiens_hsa030601.33736323
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32201726
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.27739819
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27500061
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25961727
28Butanoate metabolism_Homo sapiens_hsa006501.24903429
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24802383
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23098391
31mRNA surveillance pathway_Homo sapiens_hsa030151.16547997
32Retinol metabolism_Homo sapiens_hsa008301.16256015
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15848489
34Taste transduction_Homo sapiens_hsa047421.13025504
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.11485908
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11332091
37Ether lipid metabolism_Homo sapiens_hsa005651.10061558
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09509644
39Nicotine addiction_Homo sapiens_hsa050331.09046421
40Sulfur relay system_Homo sapiens_hsa041221.08682033
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07762984
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.03832653
43Homologous recombination_Homo sapiens_hsa034401.00141540
44Selenocompound metabolism_Homo sapiens_hsa004500.98271886
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98161493
46Chemical carcinogenesis_Homo sapiens_hsa052040.97067965
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95822192
48Peroxisome_Homo sapiens_hsa041460.94045328
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93455229
50Olfactory transduction_Homo sapiens_hsa047400.93046701
51Arachidonic acid metabolism_Homo sapiens_hsa005900.91047258
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84196298
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80629947
54Huntingtons disease_Homo sapiens_hsa050160.80174083
55Alzheimers disease_Homo sapiens_hsa050100.77086950
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.74817065
57Inositol phosphate metabolism_Homo sapiens_hsa005620.74317370
58Morphine addiction_Homo sapiens_hsa050320.73123508
59Tryptophan metabolism_Homo sapiens_hsa003800.69155844
60Salivary secretion_Homo sapiens_hsa049700.68591955
61Fat digestion and absorption_Homo sapiens_hsa049750.68384800
62Cardiac muscle contraction_Homo sapiens_hsa042600.68141014
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68091533
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63179955
65Tyrosine metabolism_Homo sapiens_hsa003500.61708000
66TGF-beta signaling pathway_Homo sapiens_hsa043500.59846742
67Ovarian steroidogenesis_Homo sapiens_hsa049130.57966841
68RNA transport_Homo sapiens_hsa030130.57627834
69N-Glycan biosynthesis_Homo sapiens_hsa005100.54301539
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.50945229
71Basal transcription factors_Homo sapiens_hsa030220.48054680
72Hippo signaling pathway_Homo sapiens_hsa043900.47366103
73Nucleotide excision repair_Homo sapiens_hsa034200.45402288
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43877376
75Fatty acid biosynthesis_Homo sapiens_hsa000610.42780888
76Metabolic pathways_Homo sapiens_hsa011000.42574019
77Gastric acid secretion_Homo sapiens_hsa049710.41439760
78Circadian entrainment_Homo sapiens_hsa047130.41231030
79Purine metabolism_Homo sapiens_hsa002300.39728517
80Fatty acid degradation_Homo sapiens_hsa000710.37546563
81Mineral absorption_Homo sapiens_hsa049780.37255846
82Hedgehog signaling pathway_Homo sapiens_hsa043400.36540431
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36274091
84Basal cell carcinoma_Homo sapiens_hsa052170.36015654
85Autoimmune thyroid disease_Homo sapiens_hsa053200.35141689
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35020632
87RNA degradation_Homo sapiens_hsa030180.34721416
88Cocaine addiction_Homo sapiens_hsa050300.34689467
89RNA polymerase_Homo sapiens_hsa030200.33847065
90Pyrimidine metabolism_Homo sapiens_hsa002400.32279099
91Insulin secretion_Homo sapiens_hsa049110.31119166
92Allograft rejection_Homo sapiens_hsa053300.30693897
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.30568444
94Starch and sucrose metabolism_Homo sapiens_hsa005000.30329787
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27870583
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27129343
97Cholinergic synapse_Homo sapiens_hsa047250.26944291
98Calcium signaling pathway_Homo sapiens_hsa040200.25291672
99Arginine and proline metabolism_Homo sapiens_hsa003300.24287824
100Dopaminergic synapse_Homo sapiens_hsa047280.24195818

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