ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	6.40070898
2	pyrimidine nucleotide catabolic process (GO:0006244)	5.38422465
3	ether lipid metabolic process (GO:0046485)	5.36621804
4	fucose catabolic process (GO:0019317)	5.07410973
5	L-fucose metabolic process (GO:0042354)	5.07410973
6	L-fucose catabolic process (GO:0042355)	5.07410973
7	cellular extravasation (GO:0045123)	4.94038261
8	regulation of chemokine biosynthetic process (GO:0045073)	4.41717545
9	valine metabolic process (GO:0006573)	4.30686523
10	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	4.03990582
11	behavioral response to nicotine (GO:0035095)	3.98845276
12	indole-containing compound catabolic process (GO:0042436)	3.93312591
13	indolalkylamine catabolic process (GO:0046218)	3.93312591
14	tryptophan catabolic process (GO:0006569)	3.93312591
15	regulation of MHC class II biosynthetic process (GO:0045346)	3.86809893
16	signal peptide processing (GO:0006465)	3.85371946
17	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.78711414
18	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.76407170
19	histone H3-K9 methylation (GO:0051567)	3.71935726
20	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.68059445
21	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.68059445
22	neutrophil mediated immunity (GO:0002446)	3.62269059
23	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.61429068
24	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	3.61429068
25	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	3.48248545
26	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.46109907
27	L-methionine salvage (GO:0071267)	3.44232007
28	L-methionine biosynthetic process (GO:0071265)	3.44232007
29	amino acid salvage (GO:0043102)	3.44232007
30	detection of light stimulus involved in visual perception (GO:0050908)	3.35562095
31	detection of light stimulus involved in sensory perception (GO:0050962)	3.35562095
32	axoneme assembly (GO:0035082)	3.33196687
33	protein K6-linked ubiquitination (GO:0085020)	3.29123837
34	DNA ligation (GO:0006266)	3.27421824
35	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.25392078
36	mitochondrion transport along microtubule (GO:0047497)	3.25392078
37	preassembly of GPI anchor in ER membrane (GO:0016254)	3.24734717
38	tryptophan metabolic process (GO:0006568)	3.23868233
39	indolalkylamine metabolic process (GO:0006586)	3.14200955
40	positive regulation of chemokine biosynthetic process (GO:0045080)	3.12959210
41	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.12315534
42	GTP biosynthetic process (GO:0006183)	3.12004262
43	seminiferous tubule development (GO:0072520)	3.11278674
44	C4-dicarboxylate transport (GO:0015740)	3.10781663
45	regulation of cilium movement (GO:0003352)	3.10382506
46	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.10349850
47	kynurenine metabolic process (GO:0070189)	3.09789981
48	prenylation (GO:0097354)	3.09408372
49	protein prenylation (GO:0018342)	3.09408372
50	DNA methylation involved in gamete generation (GO:0043046)	3.08969088
51	deoxyribonucleotide catabolic process (GO:0009264)	3.07870101
52	alanine transport (GO:0032328)	3.05604755
53	ether metabolic process (GO:0018904)	3.05483764
54	protein complex biogenesis (GO:0070271)	3.01609506
55	DNA deamination (GO:0045006)	2.94937568
56	protein polyglutamylation (GO:0018095)	2.94926689
57	pseudouridine synthesis (GO:0001522)	2.94757422
58	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.93993168
59	glycerol ether metabolic process (GO:0006662)	2.93744689
60	establishment of mitochondrion localization (GO:0051654)	2.92475720
61	piRNA metabolic process (GO:0034587)	2.92186234
62	regulation of timing of cell differentiation (GO:0048505)	2.90751961
63	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.88915662
64	modulation of growth of symbiont involved in interaction with host (GO:0044144)	2.85221358
65	regulation of growth of symbiont in host (GO:0044126)	2.85221358
66	negative regulation of growth of symbiont in host (GO:0044130)	2.85221358
67	negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	2.85221358
68	alternative mRNA splicing, via spliceosome (GO:0000380)	2.84863415
69	deoxyribose phosphate catabolic process (GO:0046386)	2.84708182
70	oxidative demethylation (GO:0070989)	2.82971087
71	adaptation of signaling pathway (GO:0023058)	2.82610167
72	histone H3-K9 modification (GO:0061647)	2.82037851
73	cellular biogenic amine catabolic process (GO:0042402)	2.81314992
74	amine catabolic process (GO:0009310)	2.81314992
75	somite development (GO:0061053)	2.76829440
76	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.76125721
77	substrate-independent telencephalic tangential migration (GO:0021826)	2.76125721
78	branched-chain amino acid catabolic process (GO:0009083)	2.74889839
79	C-terminal protein lipidation (GO:0006501)	2.74392810
80	regulation of development, heterochronic (GO:0040034)	2.74218877
81	microglial cell activation (GO:0001774)	2.72748823
82	GPI anchor metabolic process (GO:0006505)	2.71428675
83	mitochondrial respiratory chain complex assembly (GO:0033108)	2.71005157
84	cell proliferation in forebrain (GO:0021846)	2.69997262
85	myeloid leukocyte mediated immunity (GO:0002444)	2.65358972
86	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.65040406
87	epithelial cilium movement (GO:0003351)	2.63340933
88	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.62189152
89	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.62189152
90	NADH dehydrogenase complex assembly (GO:0010257)	2.62189152
91	phosphorelay signal transduction system (GO:0000160)	2.61518612
92	disruption of cells of other organism (GO:0044364)	2.59038986
93	killing of cells of other organism (GO:0031640)	2.59038986
94	GPI anchor biosynthetic process (GO:0006506)	2.58443702
95	cardiovascular system development (GO:0072358)	2.58276963
96	fucosylation (GO:0036065)	2.55917057
97	nonmotile primary cilium assembly (GO:0035058)	2.55228886
98	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.54442138
99	nucleotide transmembrane transport (GO:1901679)	2.53145734
100	cytochrome complex assembly (GO:0017004)	2.52492824

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.59992984
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.38199693
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.61491328
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.47787104
5	AR_21572438_ChIP-Seq_LNCaP_Human	3.38358594
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.96561443
7	VDR_22108803_ChIP-Seq_LS180_Human	2.51881173
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.36797493
9	IRF1_19129219_ChIP-ChIP_H3396_Human	2.31928004
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.31328706
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.29655243
12	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.12513582
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.10241113
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.10208519
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.06580449
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.06257353
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.05825353
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85974548
19	P300_19829295_ChIP-Seq_ESCs_Human	1.74017732
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.73738969
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.72685382
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.66929017
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.66579492
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.65267498
25	EWS_26573619_Chip-Seq_HEK293_Human	1.63593789
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.59366136
27	FUS_26573619_Chip-Seq_HEK293_Human	1.58105622
28	E2F7_22180533_ChIP-Seq_HELA_Human	1.53040523
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.50277069
30	REST_21632747_ChIP-Seq_MESCs_Mouse	1.45325508
31	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.40038899
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.36241261
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.33795450
34	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.32771856
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.32194929
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31581516
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31149457
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31149457
39	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.29862651
40	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.29723768
41	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29090897
42	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.27530384
43	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.27115161
44	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.25375201
45	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.25172030
46	VDR_23849224_ChIP-Seq_CD4+_Human	1.24940203
47	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.24858656
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22363500
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20497825
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17423533
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.17423533
52	FOXP3_21729870_ChIP-Seq_TREG_Human	1.16492894
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16384460
54	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.16054851
55	AR_20517297_ChIP-Seq_VCAP_Human	1.15829564
56	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.14673644
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13977549
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13977549
59	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.13477502
60	SMAD4_21799915_ChIP-Seq_A2780_Human	1.12406271
61	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.11319993
62	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.11167964
63	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.10307934
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.04362000
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04287695
66	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03461936
67	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.02642904
68	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.02452856
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.02341608
70	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.01208224
71	NCOR_22424771_ChIP-Seq_293T_Human	1.00426662
72	TCF4_23295773_ChIP-Seq_U87_Human	1.00303118
73	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00015136
74	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.99767333
75	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99061352
76	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99061352
77	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.98433160
78	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.97930274
79	MYC_19829295_ChIP-Seq_ESCs_Human	0.97642933
80	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96827733
81	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.96803810
82	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.95778062
83	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.95530625
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94484450
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94467341
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.93484313
87	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.93466120
88	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93101106
89	STAT3_23295773_ChIP-Seq_U87_Human	0.92790487
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.92352002
91	AR_25329375_ChIP-Seq_VCAP_Human	0.92135755
92	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.92118182
93	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.91524440
94	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.88625147
95	ETV1_20927104_ChIP-Seq_GIST48_Human	0.88534972
96	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.88392223
97	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.87960154
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.86712625
99	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86237522
100	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.85592721

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	4.69087742
2	MP0008877_abnormal_DNA_methylation	4.19997078
3	MP0003121_genomic_imprinting	3.19776097
4	MP0005377_hearing/vestibular/ear_phenot	2.80613296
5	MP0003878_abnormal_ear_physiology	2.80613296
6	MP0006292_abnormal_olfactory_placode	2.66596682
7	MP0003646_muscle_fatigue	2.65031547
8	MP0009379_abnormal_foot_pigmentation	2.62840011
9	MP0006072_abnormal_retinal_apoptosis	2.54859719
10	MP0002638_abnormal_pupillary_reflex	2.52969415
11	MP0003123_paternal_imprinting	2.49895429
12	MP0005551_abnormal_eye_electrophysiolog	2.46884068
13	MP0003122_maternal_imprinting	2.33868541
14	MP0002837_dystrophic_cardiac_calcinosis	2.27521705
15	MP0008789_abnormal_olfactory_epithelium	2.22944647
16	MP0004145_abnormal_muscle_electrophysio	1.96808143
17	MP0004885_abnormal_endolymph	1.88854240
18	MP0003880_abnormal_central_pattern	1.85075417
19	MP0003195_calcinosis	1.80168241
20	MP0005253_abnormal_eye_physiology	1.75835888
21	MP0005645_abnormal_hypothalamus_physiol	1.73478107
22	MP0005499_abnormal_olfactory_system	1.73286226
23	MP0005394_taste/olfaction_phenotype	1.73286226
24	MP0001968_abnormal_touch/_nociception	1.71383040
25	MP0001986_abnormal_taste_sensitivity	1.67511587
26	MP0002876_abnormal_thyroid_physiology	1.62637247
27	MP0004142_abnormal_muscle_tone	1.62447799
28	MP0001485_abnormal_pinna_reflex	1.61766928
29	MP0009046_muscle_twitch	1.56564497
30	MP0000372_irregular_coat_pigmentation	1.56384942
31	MP0004147_increased_porphyrin_level	1.55614122
32	MP0003718_maternal_effect	1.52872306
33	MP0000569_abnormal_digit_pigmentation	1.51657528
34	MP0008872_abnormal_physiological_respon	1.47459036
35	MP0008775_abnormal_heart_ventricle	1.45755468
36	MP0002736_abnormal_nociception_after	1.43406427
37	MP0002102_abnormal_ear_morphology	1.41253715
38	MP0000015_abnormal_ear_pigmentation	1.37419390
39	MP0001486_abnormal_startle_reflex	1.36503654
40	MP0002272_abnormal_nervous_system	1.34340443
41	MP0000778_abnormal_nervous_system	1.34315668
42	MP0004133_heterotaxia	1.33783116
43	MP0001529_abnormal_vocalization	1.33711155
44	MP0004742_abnormal_vestibular_system	1.29228355
45	MP0003186_abnormal_redox_activity	1.28987487
46	MP0008058_abnormal_DNA_repair	1.27614050
47	MP0002095_abnormal_skin_pigmentation	1.27226022
48	MP0005174_abnormal_tail_pigmentation	1.26497422
49	MP0000631_abnormal_neuroendocrine_gland	1.24672145
50	MP0002557_abnormal_social/conspecific_i	1.24303221
51	MP0005195_abnormal_posterior_eye	1.23865158
52	MP0005646_abnormal_pituitary_gland	1.22790254
53	MP0001440_abnormal_grooming_behavior	1.19293555
54	MP0005379_endocrine/exocrine_gland_phen	1.16888265
55	MP0001502_abnormal_circadian_rhythm	1.16886242
56	MP0001188_hyperpigmentation	1.16849680
57	MP0003136_yellow_coat_color	1.12176876
58	MP0006276_abnormal_autonomic_nervous	1.10183371
59	MP0001984_abnormal_olfaction	1.06667679
60	MP0002234_abnormal_pharynx_morphology	1.05395459
61	MP0005423_abnormal_somatic_nervous	1.01474281
62	MP0005075_abnormal_melanosome_morpholog	1.00722722
63	MP0005389_reproductive_system_phenotype	0.99172756
64	MP0002163_abnormal_gland_morphology	0.98571097
65	MP0009745_abnormal_behavioral_response	0.93554073
66	MP0008961_abnormal_basal_metabolism	0.93382871
67	MP0002233_abnormal_nose_morphology	0.92937382
68	MP0004215_abnormal_myocardial_fiber	0.91259405
69	MP0004084_abnormal_cardiac_muscle	0.89521346
70	MP0002938_white_spotting	0.86874561
71	MP0001501_abnormal_sleep_pattern	0.85727437
72	MP0001293_anophthalmia	0.84831824
73	MP0002184_abnormal_innervation	0.84445605
74	MP0002733_abnormal_thermal_nociception	0.84326737
75	MP0002160_abnormal_reproductive_system	0.83941812
76	MP0002752_abnormal_somatic_nervous	0.83380408
77	MP0002210_abnormal_sex_determination	0.82803930
78	MP0005391_vision/eye_phenotype	0.82387963
79	MP0002751_abnormal_autonomic_nervous	0.81007450
80	MP0001944_abnormal_pancreas_morphology	0.79330871
81	MP0002067_abnormal_sensory_capabilities	0.78782909
82	MP0001286_abnormal_eye_development	0.78432266
83	MP0004924_abnormal_behavior	0.77323042
84	MP0005386_behavior/neurological_phenoty	0.77323042
85	MP0008995_early_reproductive_senescence	0.77212210
86	MP0000613_abnormal_salivary_gland	0.76290042
87	MP0000427_abnormal_hair_cycle	0.75433988
88	MP0001970_abnormal_pain_threshold	0.75226255
89	MP0001919_abnormal_reproductive_system	0.72803013
90	MP0001929_abnormal_gametogenesis	0.71671183
91	MP0002229_neurodegeneration	0.68963905
92	MP0000026_abnormal_inner_ear	0.67143659
93	MP0001545_abnormal_hematopoietic_system	0.65399271
94	MP0005397_hematopoietic_system_phenotyp	0.65399271
95	MP0008875_abnormal_xenobiotic_pharmacok	0.64977574
96	MP0001663_abnormal_digestive_system	0.63768649
97	MP0001963_abnormal_hearing_physiology	0.63278210
98	MP0003698_abnormal_male_reproductive	0.63244314
99	MP0005332_abnormal_amino_acid	0.62439727
100	MP0002735_abnormal_chemical_nociception	0.62138696

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	5.54782866
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	5.27326256
3	Abnormal rod and cone electroretinograms (HP:0008323)	5.07568897
4	Pendular nystagmus (HP:0012043)	4.34580392
5	Decreased central vision (HP:0007663)	4.03860973
6	Dyskinesia (HP:0100660)	3.90343751
7	Molar tooth sign on MRI (HP:0002419)	3.61230698
8	Abnormality of midbrain morphology (HP:0002418)	3.61230698
9	Nephronophthisis (HP:0000090)	3.45559158
10	Attenuation of retinal blood vessels (HP:0007843)	3.27369279
11	Renal cortical cysts (HP:0000803)	3.26474631
12	Type II lissencephaly (HP:0007260)	3.21477977
13	Abnormality of the renal medulla (HP:0100957)	3.12909974
14	Abnormality of the renal cortex (HP:0011035)	3.10478837
15	True hermaphroditism (HP:0010459)	2.87286481
16	Pancreatic fibrosis (HP:0100732)	2.85174728
17	Pancreatic cysts (HP:0001737)	2.82193523
18	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.82179885
19	Increased corneal curvature (HP:0100692)	2.79449880
20	Keratoconus (HP:0000563)	2.79449880
21	Acute necrotizing encephalopathy (HP:0006965)	2.78174931
22	Acanthocytosis (HP:0001927)	2.69977184
23	Medial flaring of the eyebrow (HP:0010747)	2.64445802
24	Thrombocytosis (HP:0001894)	2.63818800
25	Optic disc pallor (HP:0000543)	2.62165286
26	Asplenia (HP:0001746)	2.57194378
27	Abolished electroretinogram (ERG) (HP:0000550)	2.55858087
28	Abnormality of the labia minora (HP:0012880)	2.54825703
29	Cerebral hypomyelination (HP:0006808)	2.50287214
30	Retinal dysplasia (HP:0007973)	2.44207108
31	Acute encephalopathy (HP:0006846)	2.42751524
32	Abnormality of lateral ventricle (HP:0030047)	2.38976782
33	Abnormality of eosinophils (HP:0001879)	2.38596322
34	Genetic anticipation (HP:0003743)	2.34705701
35	Macular degeneration (HP:0000608)	2.34499849
36	Septo-optic dysplasia (HP:0100842)	2.32046813
37	Abnormal mitochondria in muscle tissue (HP:0008316)	2.30171400
38	Progressive macrocephaly (HP:0004481)	2.28377821
39	Bony spicule pigmentary retinopathy (HP:0007737)	2.27340877
40	Small hand (HP:0200055)	2.26247465
41	Optic nerve hypoplasia (HP:0000609)	2.25258064
42	Tubular atrophy (HP:0000092)	2.23951903
43	Agitation (HP:0000713)	2.21935304
44	Mitochondrial inheritance (HP:0001427)	2.19351404
45	Eosinophilia (HP:0001880)	2.18327719
46	Focal motor seizures (HP:0011153)	2.13801164
47	Hyperglycinemia (HP:0002154)	2.13558048
48	CNS hypomyelination (HP:0003429)	2.11228804
49	Lissencephaly (HP:0001339)	2.05440463
50	Broad-based gait (HP:0002136)	2.02071511
51	Anencephaly (HP:0002323)	2.00648134
52	Intestinal atresia (HP:0011100)	1.99815429
53	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.98760268
54	Drooling (HP:0002307)	1.97482156
55	Constricted visual fields (HP:0001133)	1.96444411
56	Albinism (HP:0001022)	1.95789900
57	Abnormality of cells of the erythroid lineage (HP:0012130)	1.93261325
58	Brushfield spots (HP:0001088)	1.90164616
59	Hyperventilation (HP:0002883)	1.89624003
60	Pigmentary retinal degeneration (HP:0001146)	1.88576904
61	Flat capital femoral epiphysis (HP:0003370)	1.87618314
62	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87137304
63	Abnormal number of erythroid precursors (HP:0012131)	1.86908313
64	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.84589917
65	Cerebellar dysplasia (HP:0007033)	1.83397961
66	Metaphyseal dysplasia (HP:0100255)	1.82880457
67	Increased CSF lactate (HP:0002490)	1.82084430
68	Cystic liver disease (HP:0006706)	1.81102449
69	Absent/shortened dynein arms (HP:0200106)	1.80040316
70	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.80040316
71	Disproportionate short-trunk short stature (HP:0003521)	1.78738186
72	Short femoral neck (HP:0100864)	1.78284969
73	Excessive salivation (HP:0003781)	1.77589558
74	Progressive cerebellar ataxia (HP:0002073)	1.77314628
75	Short tibia (HP:0005736)	1.77002551
76	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.75475582
77	Hypoplasia of the fovea (HP:0007750)	1.75475582
78	Abnormality of macular pigmentation (HP:0008002)	1.73752906
79	Retinitis pigmentosa (HP:0000510)	1.73307894
80	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.72954170
81	Patent foramen ovale (HP:0001655)	1.72612413
82	Enlarged kidneys (HP:0000105)	1.71962535
83	Delayed CNS myelination (HP:0002188)	1.71664109
84	Widely spaced teeth (HP:0000687)	1.71520721
85	Abnormality of dental color (HP:0011073)	1.69509635
86	Adrenal hypoplasia (HP:0000835)	1.68404249
87	Delusions (HP:0000746)	1.66785557
88	Congenital hepatic fibrosis (HP:0002612)	1.66351662
89	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.66208926
90	Postaxial foot polydactyly (HP:0001830)	1.65581221
91	Sclerocornea (HP:0000647)	1.60987759
92	Abnormal drinking behavior (HP:0030082)	1.60244706
93	Polydipsia (HP:0001959)	1.60244706
94	Stomach cancer (HP:0012126)	1.59854723
95	Hyperglycinuria (HP:0003108)	1.59702110
96	Patellar aplasia (HP:0006443)	1.57806425
97	Granulocytopenia (HP:0001913)	1.57725260
98	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.56987215
99	Irregular epiphyses (HP:0010582)	1.56535601
100	Hypoplastic iliac wings (HP:0002866)	1.55078958

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.42151446
2	WNK3	3.04989948
3	WNK4	2.93172090
4	MAP4K2	2.80808921
5	CDK3	2.56520225
6	BMPR1B	2.55194477
7	ZAK	2.50381537
8	ADRBK2	2.34320956
9	NUAK1	2.31257976
10	DYRK2	2.22034133
11	PLK2	2.19026807
12	STK38L	2.09498843
13	TIE1	2.05074195
14	GRK1	1.98952798
15	PIK3CA	1.88988883
16	CDK19	1.78756756
17	CDC7	1.73817792
18	STK16	1.72199138
19	STK38	1.63085753
20	MAP3K4	1.58381328
21	NME2	1.45806657
22	STK39	1.42101247
23	INSRR	1.37719875
24	PAK3	1.19023804
25	MAPK13	1.17422646
26	NTRK2	1.11381567
27	TLK1	1.10858868
28	PKN1	1.07421438
29	EIF2AK1	1.04449830
30	PINK1	1.02201298
31	CAMK1	1.00395571
32	KIT	0.99231899
33	OXSR1	0.96826808
34	EPHB2	0.95225872
35	NTRK3	0.95035214
36	TAOK3	0.93114398
37	MST4	0.91661083
38	CASK	0.89823703
39	IRAK1	0.88312329
40	DAPK2	0.87768628
41	PRKCG	0.85160466
42	MAP4K1	0.84232213
43	FLT3	0.84028491
44	PRKCI	0.83684391
45	RPS6KA5	0.82540062
46	PRKCE	0.80017526
47	AKT3	0.77535364
48	PTK2B	0.77331927
49	OBSCN	0.76171238
50	ADRBK1	0.75968588
51	MET	0.74326863
52	MAP3K11	0.71506232
53	TEC	0.70957464
54	CCNB1	0.69048033
55	PRKACA	0.68921532
56	PRKG1	0.68866214
57	BMPR2	0.67378176
58	PRKCQ	0.67116717
59	WNK1	0.66329335
60	IRAK2	0.61724615
61	ACVR1B	0.61183062
62	PLK1	0.60829909
63	MINK1	0.60507579
64	CSNK1A1	0.59227079
65	STK4	0.58714398
66	CAMK2D	0.58422437
67	CSNK1E	0.57984439
68	IKBKB	0.55274244
69	TGFBR1	0.55089499
70	CSNK1D	0.53479606
71	ATR	0.53066488
72	TAOK1	0.52323863
73	RIPK4	0.51471723
74	GRK7	0.50443329
75	PIK3CG	0.49920625
76	CHUK	0.49755598
77	CSNK1G1	0.49131097
78	RPS6KA6	0.48718711
79	MATK	0.48700328
80	PIM2	0.48063494
81	MKNK2	0.47417570
82	ARAF	0.47068832
83	RPS6KA4	0.46539829
84	CSNK2A2	0.46132470
85	CSNK1G2	0.45939734
86	BTK	0.45877578
87	DMPK	0.45186804
88	PHKG2	0.44688318
89	PHKG1	0.44688318
90	CDK8	0.44401553
91	VRK1	0.44084141
92	PRKAA1	0.43969837
93	PLK3	0.43273828
94	CSNK2A1	0.41393374
95	CSNK1G3	0.40887266
96	BCR	0.40626647
97	PRKCH	0.39412379
98	PRKACG	0.36397068
99	PRKCA	0.35973000
100	IGF1R	0.35400316

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.44633721
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.08801476
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.64952969
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.39199279
5	Ribosome_Homo sapiens_hsa03010	2.38590514
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.32677007
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.27935476
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.27242009
9	Phototransduction_Homo sapiens_hsa04744	2.25319713
10	Butanoate metabolism_Homo sapiens_hsa00650	2.09701563
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.03933280
12	Ether lipid metabolism_Homo sapiens_hsa00565	2.01731233
13	Protein export_Homo sapiens_hsa03060	1.92912192
14	Parkinsons disease_Homo sapiens_hsa05012	1.87197155
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.86083741
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.77665952
17	Base excision repair_Homo sapiens_hsa03410	1.75444743
18	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.74081642
19	Basal transcription factors_Homo sapiens_hsa03022	1.71110923
20	One carbon pool by folate_Homo sapiens_hsa00670	1.70542216
21	DNA replication_Homo sapiens_hsa03030	1.70406367
22	RNA polymerase_Homo sapiens_hsa03020	1.61952604
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.58702585
24	Sulfur metabolism_Homo sapiens_hsa00920	1.58487334
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.53904004
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.52254431
27	RNA degradation_Homo sapiens_hsa03018	1.52163149
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.42431666
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38636477
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.34817270
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.34154844
32	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.33485078
33	Huntingtons disease_Homo sapiens_hsa05016	1.32974729
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.28056946
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.27375961
36	Alzheimers disease_Homo sapiens_hsa05010	1.25761140
37	Peroxisome_Homo sapiens_hsa04146	1.23447761
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.19951267
39	Nicotine addiction_Homo sapiens_hsa05033	1.19705777
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.13177414
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.12958621
42	Proteasome_Homo sapiens_hsa03050	1.11799216
43	Homologous recombination_Homo sapiens_hsa03440	1.09620876
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.07146748
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.03748143
46	Olfactory transduction_Homo sapiens_hsa04740	1.03033845
47	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.99249626
48	Purine metabolism_Homo sapiens_hsa00230	0.99215313
49	Morphine addiction_Homo sapiens_hsa05032	0.98174660
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.97903644
51	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.96376366
52	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.95530913
53	Caffeine metabolism_Homo sapiens_hsa00232	0.91912654
54	Propanoate metabolism_Homo sapiens_hsa00640	0.89741132
55	Primary immunodeficiency_Homo sapiens_hsa05340	0.88606442
56	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.86546458
57	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.86461647
58	Metabolic pathways_Homo sapiens_hsa01100	0.85805290
59	Lysine degradation_Homo sapiens_hsa00310	0.85585201
60	Retinol metabolism_Homo sapiens_hsa00830	0.85443635
61	Folate biosynthesis_Homo sapiens_hsa00790	0.83715470
62	GABAergic synapse_Homo sapiens_hsa04727	0.81732968
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80997329
64	Insulin secretion_Homo sapiens_hsa04911	0.80527763
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.80505665
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80257772
67	Asthma_Homo sapiens_hsa05310	0.79361298
68	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.78508526
69	Selenocompound metabolism_Homo sapiens_hsa00450	0.75267087
70	Fatty acid degradation_Homo sapiens_hsa00071	0.69896150
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68626662
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.62099578
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59727180
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.59532473
75	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.58267348
76	Sulfur relay system_Homo sapiens_hsa04122	0.57885436
77	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.57113656
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56463984
79	Serotonergic synapse_Homo sapiens_hsa04726	0.56322069
80	Renin-angiotensin system_Homo sapiens_hsa04614	0.53437964
81	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.52210553
82	Type I diabetes mellitus_Homo sapiens_hsa04940	0.49683470
83	Taste transduction_Homo sapiens_hsa04742	0.48700829
84	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.46523059
85	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.46500336
86	RNA transport_Homo sapiens_hsa03013	0.45811841
87	Fatty acid elongation_Homo sapiens_hsa00062	0.45674630
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43384554
89	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42733021
90	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.42625106
91	Salivary secretion_Homo sapiens_hsa04970	0.41649666
92	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.39295125
93	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.37126392
94	Circadian entrainment_Homo sapiens_hsa04713	0.34748598
95	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.34702510
96	Glutamatergic synapse_Homo sapiens_hsa04724	0.34040657
97	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33707455
98	Circadian rhythm_Homo sapiens_hsa04710	0.32547026
99	Mismatch repair_Homo sapiens_hsa03430	0.32457512
100	Regulation of autophagy_Homo sapiens_hsa04140	0.32078517

RPL35AP31

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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