ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.01098711
2	protein neddylation (GO:0045116)	4.31457500
3	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.20664715
4	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.20664715
5	NADH dehydrogenase complex assembly (GO:0010257)	4.20664715
6	GTP biosynthetic process (GO:0006183)	3.94059799
7	positive regulation of prostaglandin secretion (GO:0032308)	3.93939093
8	eosinophil chemotaxis (GO:0048245)	3.93306227
9	pyrimidine nucleobase catabolic process (GO:0006208)	3.93250184
10	protein complex biogenesis (GO:0070271)	3.87454075
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.83891536
12	prenylation (GO:0097354)	3.81910254
13	protein prenylation (GO:0018342)	3.81910254
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.76135341
15	ATP synthesis coupled proton transport (GO:0015986)	3.76135341
16	platelet dense granule organization (GO:0060155)	3.70776804
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.69252409
18	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.66975267
19	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.66975267
20	behavioral response to nicotine (GO:0035095)	3.64702714
21	peptidyl-histidine modification (GO:0018202)	3.60475166
22	eosinophil migration (GO:0072677)	3.58409990
23	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.56327398
24	multicellular organism reproduction (GO:0032504)	3.56000945
25	proteasome assembly (GO:0043248)	3.54538381
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.45296086
27	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	3.40267093
28	signal peptide processing (GO:0006465)	3.35668444
29	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.30954793
30	cytidine metabolic process (GO:0046087)	3.30088322
31	cytidine catabolic process (GO:0006216)	3.30088322
32	cytidine deamination (GO:0009972)	3.30088322
33	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.25408243
34	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.23003433
35	indolalkylamine metabolic process (GO:0006586)	3.21286351
36	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.21088870
37	nucleobase catabolic process (GO:0046113)	3.20080231
38	UTP biosynthetic process (GO:0006228)	3.17898088
39	regulation of prostaglandin secretion (GO:0032306)	3.17229886
40	electron transport chain (GO:0022900)	3.08039563
41	anterograde synaptic vesicle transport (GO:0048490)	3.06591828
42	respiratory electron transport chain (GO:0022904)	3.05516247
43	intraciliary transport (GO:0042073)	3.03362306
44	positive regulation of icosanoid secretion (GO:0032305)	2.97174417
45	positive regulation of fatty acid transport (GO:2000193)	2.94723454
46	cullin deneddylation (GO:0010388)	2.94702699
47	nucleoside diphosphate phosphorylation (GO:0006165)	2.91435996
48	UTP metabolic process (GO:0046051)	2.90282221
49	regulation of cilium movement (GO:0003352)	2.88202313
50	regulation of cardiac muscle cell contraction (GO:0086004)	2.84166483
51	regulation of lymphocyte chemotaxis (GO:1901623)	2.83935677
52	respiratory chain complex IV assembly (GO:0008535)	2.82336909
53	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.81935111
54	regulation of mitotic spindle checkpoint (GO:1903504)	2.81935111
55	regulation of B cell receptor signaling pathway (GO:0050855)	2.79573813
56	termination of RNA polymerase III transcription (GO:0006386)	2.77970016
57	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.77970016
58	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.76126221
59	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.74389487
60	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.72329215
61	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.71306055
62	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.68969962
63	mast cell activation (GO:0045576)	2.67616036
64	dopamine transport (GO:0015872)	2.67511535
65	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.67373357
66	CTP metabolic process (GO:0046036)	2.66285194
67	CTP biosynthetic process (GO:0006241)	2.66285194
68	positive regulation of lymphocyte migration (GO:2000403)	2.65719673
69	histone mRNA metabolic process (GO:0008334)	2.60983744
70	sperm motility (GO:0030317)	2.60760806
71	aldehyde catabolic process (GO:0046185)	2.60714254
72	regulation of relaxation of muscle (GO:1901077)	2.60623767
73	regulation of chronic inflammatory response (GO:0002676)	2.60149537
74	hydrogen ion transmembrane transport (GO:1902600)	2.58406217
75	glycerophospholipid catabolic process (GO:0046475)	2.57599502
76	kynurenine metabolic process (GO:0070189)	2.56763478
77	fucose catabolic process (GO:0019317)	2.55866055
78	L-fucose metabolic process (GO:0042354)	2.55866055
79	L-fucose catabolic process (GO:0042355)	2.55866055
80	rRNA catabolic process (GO:0016075)	2.55693715
81	tryptophan metabolic process (GO:0006568)	2.54781991
82	positive regulation of defense response to virus by host (GO:0002230)	2.53521642
83	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.52830383
84	phagocytosis, recognition (GO:0006910)	2.52654295
85	protein-cofactor linkage (GO:0018065)	2.50910084
86	endoderm formation (GO:0001706)	2.50746769
87	lateral ventricle development (GO:0021670)	2.48784803
88	proton transport (GO:0015992)	2.48720935
89	acrosome reaction (GO:0007340)	2.48178401
90	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.47983744
91	cytochrome complex assembly (GO:0017004)	2.46594927
92	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.46521234
93	water-soluble vitamin biosynthetic process (GO:0042364)	2.46004549
94	indole-containing compound catabolic process (GO:0042436)	2.45927655
95	indolalkylamine catabolic process (GO:0046218)	2.45927655
96	tryptophan catabolic process (GO:0006569)	2.45927655
97	seminiferous tubule development (GO:0072520)	2.45035082
98	hydrogen transport (GO:0006818)	2.43798588
99	maturation of 5.8S rRNA (GO:0000460)	2.43656384
100	chaperone-mediated protein transport (GO:0072321)	2.43336929

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.71181472
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.11213501
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.03170487
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.90919946
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.90250288
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.60469297
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.48349287
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.38131065
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.26164067
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.21092151
11	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.20038383
12	VDR_22108803_ChIP-Seq_LS180_Human	2.19845168
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.17844656
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.16890157
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.10281427
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.09124167
17	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.88213625
18	IRF1_19129219_ChIP-ChIP_H3396_Human	1.87594446
19	VDR_23849224_ChIP-Seq_CD4+_Human	1.87171281
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82168589
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.77560235
22	EWS_26573619_Chip-Seq_HEK293_Human	1.76835470
23	P300_19829295_ChIP-Seq_ESCs_Human	1.74837432
24	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.72021474
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.67640759
26	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.63873734
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63648937
28	GBX2_23144817_ChIP-Seq_PC3_Human	1.61258649
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.60836790
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.59104247
31	FUS_26573619_Chip-Seq_HEK293_Human	1.56244109
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.55963294
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.54213696
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54213696
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53755406
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.51422748
37	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50817631
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.49880835
39	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.49523388
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48833259
41	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.48175071
42	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.45684978
43	NANOG_19829295_ChIP-Seq_ESCs_Human	1.45232559
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.45232559
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.44648620
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43515087
47	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.41366345
48	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.35991458
49	GATA3_26560356_Chip-Seq_TH2_Human	1.35691689
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.34705630
51	ER_23166858_ChIP-Seq_MCF-7_Human	1.33922795
52	FOXP3_21729870_ChIP-Seq_TREG_Human	1.32167205
53	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.31754976
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31649484
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30594497
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30594497
57	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.29941034
58	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.27229859
59	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.26062881
60	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.21429933
61	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.21284161
62	AR_25329375_ChIP-Seq_VCAP_Human	1.21033743
63	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.20361569
64	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19561024
65	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.19305476
66	AR_20517297_ChIP-Seq_VCAP_Human	1.18702588
67	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16594666
68	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.15890265
69	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15754105
70	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.14698347
71	MYC_18940864_ChIP-ChIP_HL60_Human	1.14466174
72	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13870488
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12199334
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12143316
75	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10792032
76	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09281024
77	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09218941
78	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.09217918
79	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08350109
80	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07673716
81	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07019843
82	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.06685690
83	TCF4_23295773_ChIP-Seq_U87_Human	1.05192040
84	NCOR_22424771_ChIP-Seq_293T_Human	1.04651756
85	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.04522373
86	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.03090752
87	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02047995
88	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.01824967
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01466922
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01207872
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.99864082
92	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.99409887
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99130860
94	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99019834
95	P300_18555785_Chip-Seq_ESCs_Mouse	0.98019795
96	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.97804071
97	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.96230561
98	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95779552
99	SMAD4_21799915_ChIP-Seq_A2780_Human	0.94872771
100	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.94435737

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006054_spinal_hemorrhage	3.37477215
2	MP0000372_irregular_coat_pigmentation	3.01836534
3	MP0002653_abnormal_ependyma_morphology	2.90100293
4	MP0001835_abnormal_antigen_presentation	2.76973579
5	MP0008872_abnormal_physiological_respon	2.51136384
6	MP0006072_abnormal_retinal_apoptosis	2.39715239
7	MP0000569_abnormal_digit_pigmentation	2.38452666
8	MP0008875_abnormal_xenobiotic_pharmacok	2.35812345
9	MP0003806_abnormal_nucleotide_metabolis	2.24478623
10	MP0009379_abnormal_foot_pigmentation	2.23732678
11	MP0008789_abnormal_olfactory_epithelium	2.22670216
12	MP0003724_increased_susceptibility_to	2.11233784
13	MP0005551_abnormal_eye_electrophysiolog	2.05688823
14	MP0006292_abnormal_olfactory_placode	2.04726175
15	MP0005671_abnormal_response_to	2.02228673
16	MP0002148_abnormal_hypersensitivity_rea	1.96614920
17	MP0003880_abnormal_central_pattern	1.92646326
18	MP0003195_calcinosis	1.91656180
19	MP0002163_abnormal_gland_morphology	1.91142671
20	MP0001529_abnormal_vocalization	1.89806149
21	MP0001501_abnormal_sleep_pattern	1.83254895
22	MP0001986_abnormal_taste_sensitivity	1.77483749
23	MP0000685_abnormal_immune_system	1.75976352
24	MP0008877_abnormal_DNA_methylation	1.65849583
25	MP0004142_abnormal_muscle_tone	1.63146717
26	MP0002095_abnormal_skin_pigmentation	1.62783540
27	MP0002837_dystrophic_cardiac_calcinosis	1.59162412
28	MP0003787_abnormal_imprinting	1.59055328
29	MP0003950_abnormal_plasma_membrane	1.57268797
30	MP0005499_abnormal_olfactory_system	1.53731551
31	MP0005394_taste/olfaction_phenotype	1.53731551
32	MP0001984_abnormal_olfaction	1.52499102
33	MP0004145_abnormal_muscle_electrophysio	1.51675660
34	MP0005379_endocrine/exocrine_gland_phen	1.51010879
35	MP0005253_abnormal_eye_physiology	1.49242646
36	MP0003011_delayed_dark_adaptation	1.47560855
37	MP0009764_decreased_sensitivity_to	1.46054007
38	MP0004742_abnormal_vestibular_system	1.44486882
39	MP0001968_abnormal_touch/_nociception	1.40932794
40	MP0009785_altered_susceptibility_to	1.39831997
41	MP0003186_abnormal_redox_activity	1.37860005
42	MP0001800_abnormal_humoral_immune	1.37670746
43	MP0003121_genomic_imprinting	1.30103437
44	MP0001919_abnormal_reproductive_system	1.28850098
45	MP0000015_abnormal_ear_pigmentation	1.26829349
46	MP0002138_abnormal_hepatobiliary_system	1.22557310
47	MP0005367_renal/urinary_system_phenotyp	1.22267804
48	MP0000516_abnormal_urinary_system	1.22267804
49	MP0004782_abnormal_surfactant_physiolog	1.20139492
50	MP0002723_abnormal_immune_serum	1.19830800
51	MP0005075_abnormal_melanosome_morpholog	1.18534299
52	MP0005084_abnormal_gallbladder_morpholo	1.18273513
53	MP0005000_abnormal_immune_tolerance	1.17933366
54	MP0002272_abnormal_nervous_system	1.17633143
55	MP0003436_decreased_susceptibility_to	1.16864388
56	MP0003718_maternal_effect	1.16720677
57	MP0002736_abnormal_nociception_after	1.15765899
58	MP0002452_abnormal_antigen_presenting	1.13413556
59	MP0009745_abnormal_behavioral_response	1.12207327
60	MP0008775_abnormal_heart_ventricle	1.11476836
61	MP0005410_abnormal_fertilization	1.09969949
62	MP0009765_abnormal_xenobiotic_induced	1.09410172
63	MP0006276_abnormal_autonomic_nervous	1.05655585
64	MP0005387_immune_system_phenotype	1.04186338
65	MP0001790_abnormal_immune_system	1.04186338
66	MP0002405_respiratory_system_inflammati	1.03664862
67	MP0005167_abnormal_blood-brain_barrier	1.01616871
68	MP0000427_abnormal_hair_cycle	1.01091421
69	MP0005389_reproductive_system_phenotype	0.99579143
70	MP0008995_early_reproductive_senescence	0.98441864
71	MP0002234_abnormal_pharynx_morphology	0.96134480
72	MP0001819_abnormal_immune_cell	0.95815057
73	MP0003786_premature_aging	0.95809906
74	MP0000371_diluted_coat_color	0.95704460
75	MP0002277_abnormal_respiratory_mucosa	0.93876583
76	MP0003567_abnormal_fetal_cardiomyocyte	0.89217172
77	MP0002420_abnormal_adaptive_immunity	0.88397294
78	MP0006082_CNS_inflammation	0.88218550
79	MP0005195_abnormal_posterior_eye	0.87034105
80	MP0004215_abnormal_myocardial_fiber	0.85617423
81	MP0001324_abnormal_eye_pigmentation	0.85464584
82	MP0005174_abnormal_tail_pigmentation	0.84140312
83	MP0000230_abnormal_systemic_arterial	0.83954214
84	MP0002638_abnormal_pupillary_reflex	0.82926756
85	MP0004885_abnormal_endolymph	0.79930742
86	MP0001486_abnormal_startle_reflex	0.79108942
87	MP0000778_abnormal_nervous_system	0.78667430
88	MP0004147_increased_porphyrin_level	0.78151633
89	MP0002751_abnormal_autonomic_nervous	0.77433267
90	MP0001970_abnormal_pain_threshold	0.76336901
91	MP0001845_abnormal_inflammatory_respons	0.75607015
92	MP0001905_abnormal_dopamine_level	0.74043268
93	MP0002102_abnormal_ear_morphology	0.72772725
94	MP0000749_muscle_degeneration	0.69533799
95	MP0001177_atelectasis	0.69042821
96	MP0001853_heart_inflammation	0.68671933
97	MP0005636_abnormal_mineral_homeostasis	0.67494215
98	MP0009384_cardiac_valve_regurgitation	0.66829998
99	MP0003122_maternal_imprinting	0.66757797
100	MP0002752_abnormal_somatic_nervous	0.66031994

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.61282814
2	Acute necrotizing encephalopathy (HP:0006965)	3.71947271
3	Pancreatic cysts (HP:0001737)	3.60022462
4	Pancreatic fibrosis (HP:0100732)	3.58518579
5	Mitochondrial inheritance (HP:0001427)	3.47216321
6	Increased CSF lactate (HP:0002490)	3.40484252
7	Acute encephalopathy (HP:0006846)	3.30964617
8	Progressive macrocephaly (HP:0004481)	3.24326959
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.23658279
10	Abnormality of alanine metabolism (HP:0010916)	3.17413707
11	Hyperalaninemia (HP:0003348)	3.17413707
12	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.17413707
13	True hermaphroditism (HP:0010459)	3.14057533
14	Medial flaring of the eyebrow (HP:0010747)	3.10913008
15	Hepatocellular necrosis (HP:0001404)	3.09407268
16	Abnormality of the prostate (HP:0008775)	2.83480186
17	Absent/shortened dynein arms (HP:0200106)	2.82398388
18	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.82398388
19	Increased hepatocellular lipid droplets (HP:0006565)	2.78459914
20	Congenital primary aphakia (HP:0007707)	2.78338903
21	Gait imbalance (HP:0002141)	2.74160556
22	Keratoconus (HP:0000563)	2.67489082
23	Increased corneal curvature (HP:0100692)	2.67489082
24	Hypoproteinemia (HP:0003075)	2.66672307
25	Abnormality of midbrain morphology (HP:0002418)	2.65239755
26	Molar tooth sign on MRI (HP:0002419)	2.65239755
27	Congenital stationary night blindness (HP:0007642)	2.64973751
28	Congenital, generalized hypertrichosis (HP:0004540)	2.63193883
29	Abnormality of the labia minora (HP:0012880)	2.60914705
30	Pendular nystagmus (HP:0012043)	2.58670174
31	Lipid accumulation in hepatocytes (HP:0006561)	2.57807133
32	Nephrogenic diabetes insipidus (HP:0009806)	2.50198307
33	Fair hair (HP:0002286)	2.48954895
34	Decreased central vision (HP:0007663)	2.47085676
35	Methylmalonic aciduria (HP:0012120)	2.46053629
36	Chronic hepatic failure (HP:0100626)	2.39736976
37	Hepatic necrosis (HP:0002605)	2.39504527
38	Hyperglycinemia (HP:0002154)	2.39204516
39	Hemoptysis (HP:0002105)	2.38858841
40	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36371819
41	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.34957177
42	Sclerocornea (HP:0000647)	2.30991510
43	Type II lissencephaly (HP:0007260)	2.29176580
44	Increased serum lactate (HP:0002151)	2.28475990
45	Genital tract atresia (HP:0001827)	2.28374171
46	Cerebral edema (HP:0002181)	2.27570768
47	Nephronophthisis (HP:0000090)	2.27405575
48	Abolished electroretinogram (ERG) (HP:0000550)	2.23892730
49	Renal Fanconi syndrome (HP:0001994)	2.19534106
50	Abnormality of the renal medulla (HP:0100957)	2.18114413
51	Oligodactyly (hands) (HP:0001180)	2.11533324
52	Cystic liver disease (HP:0006706)	2.10676125
53	Abnormality of DNA repair (HP:0003254)	2.08843413
54	Prostate neoplasm (HP:0100787)	2.08220733
55	Vaginal atresia (HP:0000148)	2.07139780
56	Gastrointestinal infarctions (HP:0005244)	2.05000207
57	Generalized hypopigmentation of hair (HP:0011358)	2.02859279
58	Abnormal rod and cone electroretinograms (HP:0008323)	2.02780027
59	Reticulocytopenia (HP:0001896)	2.02412707
60	Elevated erythrocyte sedimentation rate (HP:0003565)	2.01538457
61	Hypokalemic alkalosis (HP:0001949)	2.01169797
62	Thyroiditis (HP:0100646)	2.00628904
63	Abnormal respiratory epithelium morphology (HP:0012253)	1.98843666
64	Abnormal respiratory motile cilium morphology (HP:0005938)	1.98843666
65	Optic disc pallor (HP:0000543)	1.97843486
66	Abnormality of the renal cortex (HP:0011035)	1.96875930
67	Exertional dyspnea (HP:0002875)	1.96370880
68	Parakeratosis (HP:0001036)	1.95002119
69	Abnormality of renal resorption (HP:0011038)	1.89144989
70	Abnormal biliary tract physiology (HP:0012439)	1.88847153
71	Bile duct proliferation (HP:0001408)	1.88847153
72	Lactic acidosis (HP:0003128)	1.87262375
73	Severe combined immunodeficiency (HP:0004430)	1.86921316
74	IgG deficiency (HP:0004315)	1.86457559
75	Abnormality of serum amino acid levels (HP:0003112)	1.85770758
76	Postaxial foot polydactyly (HP:0001830)	1.84498745
77	Methylmalonic acidemia (HP:0002912)	1.84355504
78	Abnormal hair whorl (HP:0010721)	1.83523933
79	Ureteral obstruction (HP:0006000)	1.81882214
80	Hyperglycinuria (HP:0003108)	1.81194693
81	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.78809872
82	Poor coordination (HP:0002370)	1.77705699
83	Optic nerve hypoplasia (HP:0000609)	1.77456514
84	Anencephaly (HP:0002323)	1.76149924
85	Abnormality of T cell number (HP:0011839)	1.75487269
86	Pulmonary fibrosis (HP:0002206)	1.75137966
87	Respiratory failure (HP:0002878)	1.74813314
88	Male pseudohermaphroditism (HP:0000037)	1.74111104
89	Attenuation of retinal blood vessels (HP:0007843)	1.73995111
90	Retinal dysplasia (HP:0007973)	1.73946161
91	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.71817080
92	Abnormal ciliary motility (HP:0012262)	1.70957135
93	Abnormality of glycine metabolism (HP:0010895)	1.70364541
94	Abnormality of serine family amino acid metabolism (HP:0010894)	1.70364541
95	Lethargy (HP:0001254)	1.70331563
96	Abnormal respiratory motile cilium physiology (HP:0012261)	1.70106252
97	Respiratory difficulties (HP:0002880)	1.69966811
98	Degeneration of anterior horn cells (HP:0002398)	1.69853196
99	Abnormality of the anterior horn cell (HP:0006802)	1.69853196
100	Abnormality of male internal genitalia (HP:0000022)	1.68973028

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.27366445
2	TLK1	2.91453992
3	BCKDK	2.85742394
4	BMPR2	2.38493840
5	STK16	2.35328270
6	TXK	2.31331084
7	ACVR1B	2.17124011
8	MAP4K2	2.15150439
9	TAOK3	2.12254450
10	SRPK1	2.06015534
11	BMPR1B	2.02100351
12	BCR	1.93572459
13	ZAK	1.91795358
14	WNK4	1.89050190
15	CAMKK2	1.82716216
16	ERBB3	1.82529829
17	EIF2AK3	1.71131455
18	WNK3	1.69006539
19	NUAK1	1.62145925
20	TRIM28	1.59669403
21	MAP3K12	1.56004420
22	ADRBK2	1.51767276
23	CDK19	1.49006382
24	GRK1	1.43820925
25	VRK2	1.42702818
26	STK39	1.38662644
27	PIK3CG	1.35576073
28	OXSR1	1.32706640
29	BUB1	1.29238967
30	BLK	1.25543227
31	KIT	1.19878167
32	PDK2	1.16914781
33	DYRK2	1.13920248
34	EPHA4	1.11867401
35	PAK3	1.11136884
36	MARK1	1.09876759
37	MST4	1.08738442
38	INSRR	1.05715140
39	FLT3	1.04704308
40	FES	1.02721450
41	SYK	1.01777361
42	PKN1	1.00806681
43	PLK2	0.98684304
44	TEC	0.98662236
45	CAMK1	0.97973572
46	CDK8	0.95251868
47	CAMK4	0.91867337
48	TRPM7	0.91414244
49	VRK1	0.90770449
50	MYLK	0.90559341
51	IKBKB	0.89828126
52	EIF2AK2	0.89271603
53	MAPK13	0.88381615
54	PINK1	0.87740001
55	TAF1	0.85627233
56	ADRBK1	0.82500071
57	PIK3CA	0.82234360
58	GRK7	0.81944467
59	MAP2K2	0.80987474
60	ERBB4	0.79600612
61	OBSCN	0.78925059
62	CSF1R	0.77675751
63	CSNK1G3	0.73202284
64	ITK	0.72129348
65	SIK3	0.70627138
66	SIK2	0.68712858
67	CSNK1A1L	0.66362560
68	LIMK1	0.66151254
69	TIE1	0.61409669
70	DAPK1	0.55588526
71	GRK6	0.52885975
72	CAMK2A	0.52366374
73	PRKCE	0.52157651
74	TNK2	0.51488017
75	MUSK	0.51455184
76	PLK3	0.51127182
77	BTK	0.49935283
78	ILK	0.49582232
79	GRK5	0.49522130
80	CSNK1G1	0.49426563
81	TNIK	0.47068412
82	IGF1R	0.47058579
83	MINK1	0.46680469
84	LYN	0.45404086
85	EGFR	0.45183367
86	PTK2B	0.45026487
87	CSNK1G2	0.44329440
88	MAP3K4	0.43724406
89	PRKCQ	0.42535778
90	RIPK4	0.42291928
91	PLK4	0.40926232
92	PRKCD	0.39923434
93	PRKACA	0.39159922
94	CSNK2A1	0.38923149
95	MAPKAPK5	0.38250580
96	PHKG1	0.37700592
97	PHKG2	0.37700592
98	TGFBR1	0.37109220
99	ABL1	0.36639250
100	AURKB	0.34249746

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.72172982
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.49907213
3	Protein export_Homo sapiens_hsa03060	3.35144274
4	Allograft rejection_Homo sapiens_hsa05330	3.09546249
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.05713029
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.93215018
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.91459097
8	Parkinsons disease_Homo sapiens_hsa05012	2.90158717
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.60070166
10	RNA polymerase_Homo sapiens_hsa03020	2.48210660
11	Proteasome_Homo sapiens_hsa03050	2.06244481
12	Alzheimers disease_Homo sapiens_hsa05010	2.00538993
13	Rheumatoid arthritis_Homo sapiens_hsa05323	1.91957072
14	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.90022655
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.83923717
16	Phototransduction_Homo sapiens_hsa04744	1.80154648
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.76547037
18	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.74856707
19	Huntingtons disease_Homo sapiens_hsa05016	1.71501449
20	Caffeine metabolism_Homo sapiens_hsa00232	1.68832290
21	Ribosome_Homo sapiens_hsa03010	1.67751057
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.62495029
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.59070719
24	RNA degradation_Homo sapiens_hsa03018	1.58523963
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.57168484
26	Homologous recombination_Homo sapiens_hsa03440	1.51145454
27	One carbon pool by folate_Homo sapiens_hsa00670	1.50105937
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.49821776
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.48114601
30	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.46670499
31	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.45530672
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.44744949
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.29726079
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.26617831
35	Viral myocarditis_Homo sapiens_hsa05416	1.22420911
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.22097798
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.13167791
38	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.10000122
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.04051351
40	Propanoate metabolism_Homo sapiens_hsa00640	0.97375835
41	Primary immunodeficiency_Homo sapiens_hsa05340	0.96006965
42	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95962760
43	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.94978221
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.94306538
45	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.92104157
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.91633230
47	Nitrogen metabolism_Homo sapiens_hsa00910	0.89775582
48	Regulation of autophagy_Homo sapiens_hsa04140	0.88630420
49	Leishmaniasis_Homo sapiens_hsa05140	0.83133687
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.81886370
51	Butanoate metabolism_Homo sapiens_hsa00650	0.79489887
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.78323189
53	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.78117849
54	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.77763706
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.76450018
56	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.75587962
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74349077
58	Basal transcription factors_Homo sapiens_hsa03022	0.72065896
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.70771867
60	Olfactory transduction_Homo sapiens_hsa04740	0.67290915
61	Morphine addiction_Homo sapiens_hsa05032	0.65578799
62	Purine metabolism_Homo sapiens_hsa00230	0.64051741
63	Peroxisome_Homo sapiens_hsa04146	0.62671673
64	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.61643967
65	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.60732338
66	Nicotine addiction_Homo sapiens_hsa05033	0.58291281
67	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.57049815
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55526562
69	Nucleotide excision repair_Homo sapiens_hsa03420	0.54873142
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54269177
71	Metabolic pathways_Homo sapiens_hsa01100	0.51852482
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51360835
73	African trypanosomiasis_Homo sapiens_hsa05143	0.50935580
74	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.47611811
75	Phagosome_Homo sapiens_hsa04145	0.41254097
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40256804
77	Spliceosome_Homo sapiens_hsa03040	0.39748812
78	RNA transport_Homo sapiens_hsa03013	0.38620440
79	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.36050937
80	Serotonergic synapse_Homo sapiens_hsa04726	0.36040063
81	Chemokine signaling pathway_Homo sapiens_hsa04062	0.35529903
82	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.34478767
83	Circadian entrainment_Homo sapiens_hsa04713	0.33378294
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.32915652
85	GABAergic synapse_Homo sapiens_hsa04727	0.32636748
86	Tuberculosis_Homo sapiens_hsa05152	0.31992313
87	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.31973436
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.30774985
89	Base excision repair_Homo sapiens_hsa03410	0.30664538
90	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.30092238
91	Mismatch repair_Homo sapiens_hsa03430	0.28549221
92	ABC transporters_Homo sapiens_hsa02010	0.28497794
93	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.28225142
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.27422407
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.26764320
96	Herpes simplex infection_Homo sapiens_hsa05168	0.26317677
97	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.24012494
98	Tyrosine metabolism_Homo sapiens_hsa00350	0.23078209
99	Taste transduction_Homo sapiens_hsa04742	0.20748974
100	Retinol metabolism_Homo sapiens_hsa00830	0.19771993

RPL35AP32

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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