RPL35AP33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Peyers patch development (GO:0048541)8.31964644
2mucosal-associated lymphoid tissue development (GO:0048537)8.31964644
3detection of light stimulus involved in visual perception (GO:0050908)7.30264357
4detection of light stimulus involved in sensory perception (GO:0050962)7.30264357
5regulation of chromatin binding (GO:0035561)6.09517255
6regulation of voltage-gated calcium channel activity (GO:1901385)5.36772181
7protein-chromophore linkage (GO:0018298)5.32063842
8serotonin metabolic process (GO:0042428)4.72668197
9behavioral response to nicotine (GO:0035095)4.65381487
10positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.64988589
11keratinocyte development (GO:0003334)4.62267102
12phosphatidylserine acyl-chain remodeling (GO:0036150)4.51800953
13primary amino compound metabolic process (GO:1901160)4.49638162
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.47337760
15phosphatidylinositol acyl-chain remodeling (GO:0036149)4.36358199
16seminiferous tubule development (GO:0072520)4.06255813
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.99961161
18ATP synthesis coupled proton transport (GO:0015986)3.99961161
19cellular ketone body metabolic process (GO:0046950)3.94699037
20activated T cell proliferation (GO:0050798)3.79251319
21DNA deamination (GO:0045006)3.69608623
22gamma-aminobutyric acid signaling pathway (GO:0007214)3.58913915
23phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.57484138
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.53008657
25tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.53008657
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.50373533
27ketone body metabolic process (GO:1902224)3.48935549
28phosphatidylcholine acyl-chain remodeling (GO:0036151)3.44384287
29water-soluble vitamin biosynthetic process (GO:0042364)3.43422004
30ribosomal small subunit assembly (GO:0000028)3.37666182
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.35961729
32spinal cord association neuron differentiation (GO:0021527)3.35033053
33synaptic transmission, glutamatergic (GO:0035249)3.28782404
34G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25288010
35regulation of inositol phosphate biosynthetic process (GO:0010919)3.24570395
36Sertoli cell development (GO:0060009)3.10755668
37positive regulation of cAMP-mediated signaling (GO:0043950)3.09696624
38viral transcription (GO:0019083)3.07903114
39negative regulation of T cell differentiation in thymus (GO:0033085)3.06252188
40adult walking behavior (GO:0007628)3.02849961
41detection of mechanical stimulus involved in sensory perception (GO:0050974)3.02266410
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02248256
43translational termination (GO:0006415)3.01702048
44neuronal action potential (GO:0019228)2.99882163
45detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98633753
46behavioral response to ethanol (GO:0048149)2.97854083
47regulation of oxidative phosphorylation (GO:0002082)2.97361182
48protein complex biogenesis (GO:0070271)2.97063588
49histone-serine phosphorylation (GO:0035404)2.96364713
50ribosome biogenesis (GO:0042254)2.96007914
51mitochondrion morphogenesis (GO:0070584)2.95939824
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.94994064
53thymus development (GO:0048538)2.94748587
54RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.92544859
55spinal cord motor neuron differentiation (GO:0021522)2.91905529
56mitochondrial respiratory chain complex assembly (GO:0033108)2.91012683
57protein localization to cilium (GO:0061512)2.88897372
58mitochondrial RNA metabolic process (GO:0000959)2.86753709
59indole-containing compound metabolic process (GO:0042430)2.86467830
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84000903
61respiratory chain complex IV assembly (GO:0008535)2.74581385
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74553701
63mitochondrial respiratory chain complex I assembly (GO:0032981)2.74553701
64NADH dehydrogenase complex assembly (GO:0010257)2.74553701
65cAMP metabolic process (GO:0046058)2.71660088
66response to acidic pH (GO:0010447)2.68670941
67cotranslational protein targeting to membrane (GO:0006613)2.67224069
68SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.66154146
69regulation of cellular respiration (GO:0043457)2.65088823
70forebrain neuron differentiation (GO:0021879)2.64795502
71protein targeting to ER (GO:0045047)2.63834912
72ventricular septum development (GO:0003281)2.63395632
73parturition (GO:0007567)2.60096762
74somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.59025073
75isotype switching (GO:0045190)2.59025073
76somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.59025073
77synaptic transmission, cholinergic (GO:0007271)2.58773611
78epithelial cilium movement (GO:0003351)2.58617519
79intracellular protein transmembrane import (GO:0044743)2.58067606
80cellular response to interferon-beta (GO:0035458)2.55445696
81adipose tissue development (GO:0060612)2.55375466
82ncRNA catabolic process (GO:0034661)2.55054130
83regulation of posttranscriptional gene silencing (GO:0060147)2.54414735
84regulation of gene silencing by miRNA (GO:0060964)2.54414735
85regulation of gene silencing by RNA (GO:0060966)2.54414735
86ribonucleoprotein complex biogenesis (GO:0022613)2.54317614
87cytochrome complex assembly (GO:0017004)2.53194861
88cytoplasmic mRNA processing body assembly (GO:0033962)2.52935730
89histone H4-K12 acetylation (GO:0043983)2.51838062
90positive regulation of mRNA catabolic process (GO:0061014)2.51756184
91kynurenine metabolic process (GO:0070189)2.51597942
92proteasome assembly (GO:0043248)2.51462640
93phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.51030975
94establishment of protein localization to endoplasmic reticulum (GO:0072599)2.48922034
95rRNA catabolic process (GO:0016075)2.48781842
96protein localization to endoplasmic reticulum (GO:0070972)2.48460442
97skeletal muscle tissue regeneration (GO:0043403)2.47927176
98cellular component biogenesis (GO:0044085)2.47319148
99neuronal action potential propagation (GO:0019227)11.6700319
100gamma-aminobutyric acid transport (GO:0015812)10.5987014

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.69842347
2VDR_22108803_ChIP-Seq_LS180_Human3.66273185
3ZNF274_21170338_ChIP-Seq_K562_Hela3.44536087
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.35043042
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.96292917
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65122672
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.39234038
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14812031
9EWS_26573619_Chip-Seq_HEK293_Human2.11937722
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05464242
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05346408
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02916959
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01547897
14BCAT_22108803_ChIP-Seq_LS180_Human1.96814577
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92673184
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.86920028
17IRF1_19129219_ChIP-ChIP_H3396_Human1.85392010
18ER_23166858_ChIP-Seq_MCF-7_Human1.84929055
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.82108103
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82090972
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80194682
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.77109960
23IGF1R_20145208_ChIP-Seq_DFB_Human1.73562978
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71143343
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65855485
26GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.60334452
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59612048
28TAF15_26573619_Chip-Seq_HEK293_Human1.59225759
29TDRD3_21172665_ChIP-Seq_MCF-7_Human1.55130394
30TP53_16413492_ChIP-PET_HCT116_Human1.55073250
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.49597261
32FOXA1_25329375_ChIP-Seq_VCAP_Human1.46670190
33FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46670190
34GBX2_23144817_ChIP-Seq_PC3_Human1.46291419
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45051027
36REST_21632747_ChIP-Seq_MESCs_Mouse1.44039302
37TP53_22573176_ChIP-Seq_HFKS_Human1.43468276
38P300_19829295_ChIP-Seq_ESCs_Human1.42606249
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41275443
40MYC_18940864_ChIP-ChIP_HL60_Human1.40853841
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38673514
42RUNX2_22187159_ChIP-Seq_PCA_Human1.35831652
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32835293
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31197140
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27857445
46AR_25329375_ChIP-Seq_VCAP_Human1.26296514
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26185935
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.24408909
49RNF2_27304074_Chip-Seq_NSC_Mouse1.22215186
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.22060599
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21442691
52STAT3_23295773_ChIP-Seq_U87_Human1.17524433
53DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16780667
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16652219
55P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16233999
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.15607194
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.14898333
58VDR_23849224_ChIP-Seq_CD4+_Human1.14072190
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.13559071
60FOXH1_21741376_ChIP-Seq_EPCs_Human1.11981146
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11953082
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11096721
63CBP_20019798_ChIP-Seq_JUKART_Human1.11096721
64TCF4_23295773_ChIP-Seq_U87_Human1.10623692
65JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10474153
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09495876
67RNF2_27304074_Chip-Seq_ESCs_Mouse1.09356203
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.08371818
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06582508
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05602664
71NCOR_22424771_ChIP-Seq_293T_Human1.04207957
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03733397
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03598602
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02836959
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.01925013
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01080282
77FUS_26573619_Chip-Seq_HEK293_Human1.00662640
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00506414
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00222492
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.00100274
81SMAD3_21741376_ChIP-Seq_EPCs_Human0.99253655
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98581138
83P53_22387025_ChIP-Seq_ESCs_Mouse0.98459805
84OCT1_27270436_Chip-Seq_PROSTATE_Human0.96960769
85NANOG_18555785_Chip-Seq_ESCs_Mouse0.96679079
86HTT_18923047_ChIP-ChIP_STHdh_Human0.94276512
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93419985
88SMAD4_21799915_ChIP-Seq_A2780_Human0.93106034
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.92951021
90TAL1_26923725_Chip-Seq_HPCs_Mouse0.92147984
91HOXB7_26014856_ChIP-Seq_BT474_Human0.90196721
92P53_21459846_ChIP-Seq_SAOS-2_Human0.89732148
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89707933
94NMYC_18555785_Chip-Seq_ESCs_Mouse0.88240138
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88233540
96EZH2_27294783_Chip-Seq_ESCs_Mouse0.87293792
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.87026521
98TCF4_22108803_ChIP-Seq_LS180_Human0.86800975
99GATA1_22025678_ChIP-Seq_K562_Human0.85494296
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84756132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.98353984
2MP0008789_abnormal_olfactory_epithelium3.49225157
3MP0005645_abnormal_hypothalamus_physiol3.16443408
4MP0008877_abnormal_DNA_methylation2.91627653
5MP0008875_abnormal_xenobiotic_pharmacok2.89512271
6MP0006292_abnormal_olfactory_placode2.84839360
7MP0003880_abnormal_central_pattern2.77192398
8MP0001529_abnormal_vocalization2.73021776
9MP0005394_taste/olfaction_phenotype2.70498253
10MP0005499_abnormal_olfactory_system2.70498253
11MP0005671_abnormal_response_to2.60022830
12MP0009745_abnormal_behavioral_response2.50305627
13MP0001968_abnormal_touch/_nociception2.40822072
14MP0000631_abnormal_neuroendocrine_gland2.39620883
15MP0002736_abnormal_nociception_after2.24942213
16MP0003195_calcinosis2.24686383
17MP0005408_hypopigmentation2.23888162
18MP0002272_abnormal_nervous_system2.21142332
19MP0003315_abnormal_perineum_morphology2.17547907
20MP0009046_muscle_twitch2.16806778
21MP0005386_behavior/neurological_phenoty1.99074569
22MP0004924_abnormal_behavior1.99074569
23MP0005389_reproductive_system_phenotype1.96716180
24MP0001919_abnormal_reproductive_system1.96554711
25MP0009379_abnormal_foot_pigmentation1.96201580
26MP0005551_abnormal_eye_electrophysiolog1.94464060
27MP0001542_abnormal_bone_strength1.93830004
28MP0003646_muscle_fatigue1.89644658
29MP0005423_abnormal_somatic_nervous1.83305126
30MP0006276_abnormal_autonomic_nervous1.72626129
31MP0001486_abnormal_startle_reflex1.61654853
32MP0004142_abnormal_muscle_tone1.57620596
33MP0002160_abnormal_reproductive_system1.55781468
34MP0002837_dystrophic_cardiac_calcinosis1.53372084
35MP0004147_increased_porphyrin_level1.48284123
36MP0000685_abnormal_immune_system1.48104237
37MP0000639_abnormal_adrenal_gland1.46228014
38MP0005187_abnormal_penis_morphology1.45238369
39MP0003866_abnormal_defecation1.43110523
40MP0002067_abnormal_sensory_capabilities1.38855748
41MP0002572_abnormal_emotion/affect_behav1.36751542
42MP0002163_abnormal_gland_morphology1.35540027
43MP0002557_abnormal_social/conspecific_i1.35022696
44MP0004742_abnormal_vestibular_system1.31488684
45MP0002064_seizures1.28724565
46MP0004019_abnormal_vitamin_homeostasis1.26707478
47MP0008872_abnormal_physiological_respon1.26488625
48MP0001970_abnormal_pain_threshold1.21998741
49MP0002653_abnormal_ependyma_morphology1.21664130
50MP0002734_abnormal_mechanical_nocicepti1.16205051
51MP0002735_abnormal_chemical_nociception1.15275602
52MP0003693_abnormal_embryo_hatching1.13732375
53MP0003635_abnormal_synaptic_transmissio1.13085369
54MP0001440_abnormal_grooming_behavior1.12839035
55MP0002938_white_spotting1.10380387
56MP0005379_endocrine/exocrine_gland_phen1.07790949
57MP0005410_abnormal_fertilization1.07670532
58MP0001963_abnormal_hearing_physiology1.07296910
59MP0003878_abnormal_ear_physiology1.07083891
60MP0005377_hearing/vestibular/ear_phenot1.07083891
61MP0001986_abnormal_taste_sensitivity1.04117481
62MP0003806_abnormal_nucleotide_metabolis1.04059528
63MP0002638_abnormal_pupillary_reflex0.99026156
64MP0001485_abnormal_pinna_reflex0.98526255
65MP0001835_abnormal_antigen_presentation0.94141894
66MP0002733_abnormal_thermal_nociception0.92968866
67MP0001790_abnormal_immune_system0.92661715
68MP0005387_immune_system_phenotype0.92661715
69MP0001905_abnormal_dopamine_level0.92535711
70MP0002210_abnormal_sex_determination0.91439153
71MP0002277_abnormal_respiratory_mucosa0.91264783
72MP0000613_abnormal_salivary_gland0.91256088
73MP0003938_abnormal_ear_development0.90868443
74MP0005451_abnormal_body_composition0.90790799
75MP0003119_abnormal_digestive_system0.90116184
76MP0001873_stomach_inflammation0.89592158
77MP0002138_abnormal_hepatobiliary_system0.89416042
78MP0003698_abnormal_male_reproductive0.87291381
79MP0009764_decreased_sensitivity_to0.87258239
80MP0000372_irregular_coat_pigmentation0.85009760
81MP0002752_abnormal_somatic_nervous0.83914413
82MP0003136_yellow_coat_color0.81866189
83MP0002822_catalepsy0.81520162
84MP0001929_abnormal_gametogenesis0.81335940
85MP0000653_abnormal_sex_gland0.81023559
86MP0000026_abnormal_inner_ear0.80403353
87MP0002063_abnormal_learning/memory/cond0.79368008
88MP0003638_abnormal_response/metabolism_0.79127093
89MP0003718_maternal_effect0.78255463
90MP0001119_abnormal_female_reproductive0.76157317
91MP0001293_anophthalmia0.74763838
92MP0005503_abnormal_tendon_morphology0.74012069
93MP0005647_abnormal_sex_gland0.73637657
94MP0005167_abnormal_blood-brain_barrier0.72928191
95MP0002184_abnormal_innervation0.72293615
96MP0001501_abnormal_sleep_pattern0.71629609
97MP0001800_abnormal_humoral_immune0.71216916
98MP0000049_abnormal_middle_ear0.69749624
99MP0003122_maternal_imprinting0.67386712
100MP0000566_synostosis0.67162631

Predicted human phenotypes

RankGene SetZ-score
1Bilateral sensorineural hearing impairment (HP:0008619)7.86982923
2Hyperventilation (HP:0002883)5.43160919
3Gaze-evoked nystagmus (HP:0000640)5.14642526
4Tinnitus (HP:0000360)4.68928331
5Absent rod-and cone-mediated responses on ERG (HP:0007688)4.40251558
6Tubular atrophy (HP:0000092)4.25319249
7Abnormality of dentin (HP:0010299)4.17349891
8Febrile seizures (HP:0002373)3.81432638
9Stomatitis (HP:0010280)3.77757099
10Abnormal drinking behavior (HP:0030082)3.69126719
11Polydipsia (HP:0001959)3.69126719
123-Methylglutaconic aciduria (HP:0003535)3.56876942
13Tubulointerstitial fibrosis (HP:0005576)3.42438634
14Inappropriate behavior (HP:0000719)3.29705528
15Congenital, generalized hypertrichosis (HP:0004540)3.16255289
16Dyskinesia (HP:0100660)3.16163385
17Abnormality of the renal cortex (HP:0011035)3.12044149
18Abnormal rod and cone electroretinograms (HP:0008323)3.11614704
19Attenuation of retinal blood vessels (HP:0007843)2.93571385
20Pancreatic cysts (HP:0001737)2.90450494
21Acanthocytosis (HP:0001927)2.88614319
22Enlarged penis (HP:0000040)2.83828466
23Abnormality of midbrain morphology (HP:0002418)2.78295995
24Molar tooth sign on MRI (HP:0002419)2.78295995
25Nephronophthisis (HP:0000090)2.75075852
26Abnormality of the renal medulla (HP:0100957)2.74785851
27Atonic seizures (HP:0010819)2.68367058
28Decreased central vision (HP:0007663)2.66364625
29Polyuria (HP:0000103)2.64748891
30Hemiparesis (HP:0001269)2.62053219
31Drooling (HP:0002307)2.57007015
32Focal motor seizures (HP:0011153)2.55302635
33Abnormality of the dental pulp (HP:0006479)2.53413799
34Concave nail (HP:0001598)2.53013360
35Inability to walk (HP:0002540)2.52989637
36Acute necrotizing encephalopathy (HP:0006965)2.52082988
37Tubulointerstitial abnormality (HP:0001969)2.52034455
38Severe muscular hypotonia (HP:0006829)2.48610164
39Mitochondrial inheritance (HP:0001427)2.46841362
40Acute encephalopathy (HP:0006846)2.45380110
41Clumsiness (HP:0002312)2.41763426
42Medial flaring of the eyebrow (HP:0010747)2.40587719
43Small hand (HP:0200055)2.40224807
44Excessive salivation (HP:0003781)2.36563889
45Status epilepticus (HP:0002133)2.36419949
46Flat occiput (HP:0005469)2.35037509
47Focal seizures (HP:0007359)2.33866575
48Broad-based gait (HP:0002136)2.32075421
49Birth length less than 3rd percentile (HP:0003561)2.28803607
50Pendular nystagmus (HP:0012043)2.25363359
51Bile duct proliferation (HP:0001408)2.25326877
52Abnormal biliary tract physiology (HP:0012439)2.25326877
53Pancreatic fibrosis (HP:0100732)2.24967934
54Gonadotropin excess (HP:0000837)2.23138137
55Increased CSF lactate (HP:0002490)2.22176219
56Methylmalonic acidemia (HP:0002912)2.21356696
57Enlarged kidneys (HP:0000105)2.19824892
58Generalized myoclonic seizures (HP:0002123)2.19604160
59Abnormality of the diencephalon (HP:0010662)2.19387740
60Lipid accumulation in hepatocytes (HP:0006561)2.16698457
61Abnormal urine output (HP:0012590)2.16461455
62Fair hair (HP:0002286)2.16282503
63Increased hepatocellular lipid droplets (HP:0006565)2.15035631
64Poor eye contact (HP:0000817)2.13022632
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.12853237
66Bulbous nose (HP:0000414)2.12750537
67Hyperglycinemia (HP:0002154)2.11053326
68Adrenal hypoplasia (HP:0000835)2.08528287
69Abnormality of renal excretion (HP:0011036)2.04762975
70Optic disc pallor (HP:0000543)2.03124237
71Abnormal mitochondria in muscle tissue (HP:0008316)2.02019562
72Potter facies (HP:0002009)1.99908668
73Facial shape deformation (HP:0011334)1.99908668
74Protruding tongue (HP:0010808)1.99491732
75Abnormality of secondary sexual hair (HP:0009888)1.98066180
76Abnormality of the axillary hair (HP:0100134)1.98066180
77Progressive macrocephaly (HP:0004481)1.93770913
78Hypoplasia of the radius (HP:0002984)1.89768776
79Widely spaced teeth (HP:0000687)1.83875414
80Abnormality of homocysteine metabolism (HP:0010919)1.83221259
81Homocystinuria (HP:0002156)1.83221259
82Forearm undergrowth (HP:0009821)1.82881787
83Aplasia/Hypoplasia of the spleen (HP:0010451)1.82369088
84Dynein arm defect of respiratory motile cilia (HP:0012255)1.81755864
85Absent/shortened dynein arms (HP:0200106)1.81755864
86Cortical visual impairment (HP:0100704)1.81422576
87Progressive microcephaly (HP:0000253)1.80585946
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78141088
89Abnormality of alanine metabolism (HP:0010916)1.78141088
90Hyperalaninemia (HP:0003348)1.78141088
91Hepatocellular necrosis (HP:0001404)1.76287983
92Bony spicule pigmentary retinopathy (HP:0007737)1.74984305
93Disinhibition (HP:0000734)1.74247273
94Partial agenesis of the corpus callosum (HP:0001338)1.73343375
95Increased corneal curvature (HP:0100692)1.73109215
96Keratoconus (HP:0000563)1.73109215
97Asplenia (HP:0001746)1.72881820
98Abnormality of the vitamin B12 metabolism (HP:0004341)1.72427693
99Fibular hypoplasia (HP:0003038)1.68805955
100Patellar aplasia (HP:0006443)1.67504960

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.64208748
2FRK3.66277096
3MKNK23.64101880
4MAP3K43.11232578
5MAP2K73.09259973
6ZAK2.87395453
7WNK42.86438535
8PIK3CA2.48826052
9PTK2B2.43257720
10GRK12.41219645
11AKT32.20685549
12SIK22.16606537
13TLK12.14492513
14ADRBK22.07093051
15TNIK1.86536011
16MKNK11.84914120
17BRAF1.72632063
18NEK11.70005843
19MAP3K61.66132597
20STK391.63641944
21MAP4K21.62407252
22NTRK21.61505009
23INSRR1.53904568
24OXSR11.46705024
25NTRK11.39304433
26BMPR1B1.34547446
27ARAF1.28689539
28PRKCG1.24719213
29LIMK11.21745366
30NEK21.16988485
31VRK10.98370681
32DAPK20.95445503
33RPS6KA60.92066401
34PKN10.90978946
35PLK40.90574018
36WNK30.89719569
37RPS6KA50.88804748
38PHKG10.85635020
39PHKG20.85635020
40NME10.84893061
41ADRBK10.82454929
42NUAK10.82418586
43CSNK1D0.81335180
44MOS0.79395516
45MAP2K40.77782906
46PDK20.77150452
47FES0.75710649
48CAMK40.75437881
49TNK20.73868895
50PASK0.72563609
51NTRK30.69727660
52PRKCQ0.68237479
53IKBKB0.67594502
54IKBKE0.67346953
55STK380.66590542
56MAPK130.64698206
57PRKD30.60343181
58KIT0.59116660
59CAMK10.59109627
60MARK10.58685287
61BTK0.58599677
62TAOK20.55714179
63SGK20.54799067
64BCKDK0.53252933
65CAMK2A0.51167504
66CAMKK20.50704748
67RPS6KB20.50131037
68DYRK30.49545102
69TXK0.48512743
70LYN0.46973442
71PLK10.46914452
72EIF2AK10.46777683
73PRKCD0.45336840
74DYRK20.44698178
75MAP2K20.44150800
76CAMK1D0.44142090
77CHEK20.42469334
78PRKCE0.42071779
79PINK10.41514332
80TYK20.40865063
81PRKACA0.39983165
82ATR0.39601823
83VRK20.38069573
84TAF10.37426149
85CASK0.36307725
86PLK20.35507362
87EPHA40.35053312
88CSNK2A10.34103659
89TGFBR10.33152900
90CAMK2D0.32609620
91CSNK1E0.32535995
92TIE10.31493376
93SGK30.31044117
94NEK90.30739866
95MUSK0.29741580
96MAP3K130.29468385
97SGK4940.29451883
98SGK2230.29451883
99CDC70.28351651
100GRK50.28094276

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.85048656
2Linoleic acid metabolism_Homo sapiens_hsa005913.80034937
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.33939944
4Ribosome_Homo sapiens_hsa030103.33878117
5Oxidative phosphorylation_Homo sapiens_hsa001903.00315638
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.61995081
7Parkinsons disease_Homo sapiens_hsa050122.36153664
8Cardiac muscle contraction_Homo sapiens_hsa042602.33006261
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.23993185
10Nitrogen metabolism_Homo sapiens_hsa009102.11412520
11Ether lipid metabolism_Homo sapiens_hsa005652.11279777
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97605352
13Nicotine addiction_Homo sapiens_hsa050331.83819029
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71550791
15Protein export_Homo sapiens_hsa030601.70713658
16RNA degradation_Homo sapiens_hsa030181.69990980
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68709769
18Asthma_Homo sapiens_hsa053101.66445132
19Arachidonic acid metabolism_Homo sapiens_hsa005901.58683461
20Alzheimers disease_Homo sapiens_hsa050101.58330608
21Ovarian steroidogenesis_Homo sapiens_hsa049131.57038888
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.54064222
23Huntingtons disease_Homo sapiens_hsa050161.52379529
24Butanoate metabolism_Homo sapiens_hsa006501.51983822
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51555956
26Homologous recombination_Homo sapiens_hsa034401.50714781
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49785415
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47727242
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42968992
30Nucleotide excision repair_Homo sapiens_hsa034201.37128355
31Olfactory transduction_Homo sapiens_hsa047401.36698898
32Caffeine metabolism_Homo sapiens_hsa002321.28938429
33Basal transcription factors_Homo sapiens_hsa030221.27158123
34Sulfur relay system_Homo sapiens_hsa041221.21390383
35Glutamatergic synapse_Homo sapiens_hsa047241.19639728
36Proteasome_Homo sapiens_hsa030501.11391131
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02946274
38Phototransduction_Homo sapiens_hsa047441.02024793
39Taste transduction_Homo sapiens_hsa047421.01681467
40Allograft rejection_Homo sapiens_hsa053300.95290961
41Autoimmune thyroid disease_Homo sapiens_hsa053200.95103367
42Chemical carcinogenesis_Homo sapiens_hsa052040.90665988
43RNA polymerase_Homo sapiens_hsa030200.87065058
44Base excision repair_Homo sapiens_hsa034100.86914033
45Fat digestion and absorption_Homo sapiens_hsa049750.85952815
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85315319
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.84634143
48Primary immunodeficiency_Homo sapiens_hsa053400.83834692
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83400737
50One carbon pool by folate_Homo sapiens_hsa006700.82345017
51Long-term depression_Homo sapiens_hsa047300.82281131
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81207016
53Retinol metabolism_Homo sapiens_hsa008300.78760405
54Fanconi anemia pathway_Homo sapiens_hsa034600.78159413
55Oxytocin signaling pathway_Homo sapiens_hsa049210.72970491
56Morphine addiction_Homo sapiens_hsa050320.72003906
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71976639
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71739627
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71277162
60Peroxisome_Homo sapiens_hsa041460.69391411
61Selenocompound metabolism_Homo sapiens_hsa004500.65790974
62Tryptophan metabolism_Homo sapiens_hsa003800.65291569
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62047624
64Starch and sucrose metabolism_Homo sapiens_hsa005000.61753247
65Purine metabolism_Homo sapiens_hsa002300.60717102
66Amphetamine addiction_Homo sapiens_hsa050310.60235809
67Serotonergic synapse_Homo sapiens_hsa047260.60018729
68Circadian entrainment_Homo sapiens_hsa047130.58588927
69Cocaine addiction_Homo sapiens_hsa050300.58077629
70Glycerolipid metabolism_Homo sapiens_hsa005610.56442798
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53785932
72Gastric acid secretion_Homo sapiens_hsa049710.53648187
73Calcium signaling pathway_Homo sapiens_hsa040200.53520036
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.53207834
75Vitamin B6 metabolism_Homo sapiens_hsa007500.52544917
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.51159826
77Non-homologous end-joining_Homo sapiens_hsa034500.49333930
78MAPK signaling pathway_Homo sapiens_hsa040100.48777069
79Metabolic pathways_Homo sapiens_hsa011000.46568052
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46333136
81Mineral absorption_Homo sapiens_hsa049780.45967952
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45959750
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45587299
84Dopaminergic synapse_Homo sapiens_hsa047280.44475003
85Pyrimidine metabolism_Homo sapiens_hsa002400.44155278
86N-Glycan biosynthesis_Homo sapiens_hsa005100.42536272
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40756219
88Regulation of autophagy_Homo sapiens_hsa041400.40754882
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40663529
90Circadian rhythm_Homo sapiens_hsa047100.40603742
91cAMP signaling pathway_Homo sapiens_hsa040240.39313657
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.38660053
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.38167039
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35823110
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33823243
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33029822
97Spliceosome_Homo sapiens_hsa030400.32483636
98GABAergic synapse_Homo sapiens_hsa047270.31110456
99Insulin secretion_Homo sapiens_hsa049110.30439682
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29592435

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