ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	5.68889926
2	maturation of SSU-rRNA (GO:0030490)	5.61435968
3	viral transcription (GO:0019083)	5.57200227
4	translational termination (GO:0006415)	5.25049094
5	positive regulation of respiratory burst (GO:0060267)	5.05094688
6	cytidine deamination (GO:0009972)	5.02318935
7	cytidine metabolic process (GO:0046087)	5.02318935
8	cytidine catabolic process (GO:0006216)	5.02318935
9	negative regulation of T cell differentiation in thymus (GO:0033085)	4.82238375
10	negative regulation by host of viral transcription (GO:0043922)	4.78303796
11	parturition (GO:0007567)	4.63318740
12	DNA deamination (GO:0045006)	4.61199923
13	ribosomal small subunit assembly (GO:0000028)	4.60498536
14	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.60050399
15	translational elongation (GO:0006414)	4.51756477
16	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.51586966
17	protein targeting to ER (GO:0045047)	4.51060502
18	cotranslational protein targeting to membrane (GO:0006613)	4.47028505
19	protein localization to endoplasmic reticulum (GO:0070972)	4.37079040
20	eosinophil chemotaxis (GO:0048245)	4.33393633
21	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.28060028
22	response to xenobiotic stimulus (GO:0009410)	4.24048279
23	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.07669830
24	positive regulation of growth hormone secretion (GO:0060124)	4.04519180
25	viral life cycle (GO:0019058)	4.00922908
26	cellular protein complex disassembly (GO:0043624)	4.00643970
27	protein neddylation (GO:0045116)	3.95066132
28	ATP synthesis coupled proton transport (GO:0015986)	3.92701113
29	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.92701113
30	eosinophil migration (GO:0072677)	3.90065164
31	behavioral response to nicotine (GO:0035095)	3.85353424
32	substrate-independent telencephalic tangential migration (GO:0021826)	3.77982529
33	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.77982529
34	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.75298262
35	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.66035248
36	glutathione biosynthetic process (GO:0006750)	3.65011725
37	glycerophospholipid catabolic process (GO:0046475)	3.61943757
38	nonribosomal peptide biosynthetic process (GO:0019184)	3.59956173
39	positive regulation of T cell apoptotic process (GO:0070234)	3.53626770
40	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.51416458
41	negative regulation of cell killing (GO:0031342)	3.46826566
42	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	3.46826566
43	regulation of T cell mediated cytotoxicity (GO:0001914)	3.43995069
44	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.41872451
45	ribosomal large subunit biogenesis (GO:0042273)	3.39952695
46	protein complex disassembly (GO:0043241)	3.39561780
47	growth hormone secretion (GO:0030252)	3.38569164
48	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	3.37760136
49	L-fucose catabolic process (GO:0042355)	3.34089119
50	fucose catabolic process (GO:0019317)	3.34089119
51	L-fucose metabolic process (GO:0042354)	3.34089119
52	mast cell activation (GO:0045576)	3.32221964
53	positive regulation of calcium-mediated signaling (GO:0050850)	3.29623141
54	macromolecular complex disassembly (GO:0032984)	3.26601705
55	auditory receptor cell differentiation (GO:0042491)	3.24224660
56	regulation of growth hormone secretion (GO:0060123)	3.21803657
57	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.20500997
58	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.20500997
59	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.20236904
60	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.20236904
61	interferon-gamma production (GO:0032609)	3.18148598
62	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.16999667
63	regulation of respiratory burst (GO:0060263)	3.16036140
64	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.15480625
65	cAMP-mediated signaling (GO:0019933)	3.15222608
66	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.15215481
67	protein complex biogenesis (GO:0070271)	3.14729072
68	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	3.13033655
69	GDP-mannose metabolic process (GO:0019673)	3.12382630
70	cysteine metabolic process (GO:0006534)	3.12350684
71	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.10620189
72	NADH dehydrogenase complex assembly (GO:0010257)	3.10620189
73	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.10620189
74	regulation of T cell differentiation in thymus (GO:0033081)	3.09884086
75	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.05872341
76	phenylpropanoid metabolic process (GO:0009698)	3.04376193
77	protein targeting to membrane (GO:0006612)	3.00726653
78	translational initiation (GO:0006413)	3.00128381
79	rRNA catabolic process (GO:0016075)	2.94138891
80	regulation of lymphocyte chemotaxis (GO:1901623)	2.93165283
81	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.90170455
82	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.90037638
83	negative regulation of T cell mediated immunity (GO:0002710)	2.86720058
84	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.81398663
85	antibacterial humoral response (GO:0019731)	2.80647473
86	regulation of relaxation of muscle (GO:1901077)	2.79662542
87	mast cell degranulation (GO:0043303)	2.77796869
88	mast cell activation involved in immune response (GO:0002279)	2.77796869
89	GTP biosynthetic process (GO:0006183)	2.77557381
90	regulation of guanylate cyclase activity (GO:0031282)	2.76934275
91	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.75082744
92	cellular response to nicotine (GO:0071316)	2.74959758
93	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.74395928
94	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.73742749
95	negative regulation of stress fiber assembly (GO:0051497)	2.72813436
96	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.72503804
97	cellular component biogenesis (GO:0044085)	2.72459193
98	mitochondrial respiratory chain complex assembly (GO:0033108)	2.72032965
99	viral protein processing (GO:0019082)	2.71332352
100	negative regulation of viral transcription (GO:0032897)	2.68285366

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	9.13962842
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.12543123
3	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	4.08186182
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.47686426
5	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.08834078
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.94067213
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.45093501
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.32713939
9	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.04129035
10	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.93730730
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.86561120
12	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.85016094
13	NANOG_20526341_ChIP-Seq_ESCs_Human	1.82352073
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.79046928
15	ZNF274_21170338_ChIP-Seq_K562_Hela	1.75542914
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.67013776
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.66962399
18	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.63594098
19	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.63160253
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61015351
21	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.57962002
22	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.56516812
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.56080149
24	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.46887045
25	CTCF_20526341_ChIP-Seq_ESCs_Human	1.40086581
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.39519139
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.38123684
28	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.36363797
29	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.34361690
30	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.31895059
31	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.31324982
32	VDR_22108803_ChIP-Seq_LS180_Human	1.31066669
33	TAF2_19829295_ChIP-Seq_ESCs_Human	1.30704004
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.30320319
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29544922
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29544922
37	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.27342271
38	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.27147144
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.26901829
40	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.26815562
41	SA1_27219007_Chip-Seq_Bcells_Human	1.26015887
42	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.25473125
43	P53_21459846_ChIP-Seq_SAOS-2_Human	1.24206760
44	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.22985450
45	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.22593408
46	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.21961924
47	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.21824461
48	MYC_19829295_ChIP-Seq_ESCs_Human	1.21721834
49	ERA_21632823_ChIP-Seq_H3396_Human	1.21443386
50	GATA3_26560356_Chip-Seq_TH2_Human	1.15265484
51	BCL6_27268052_Chip-Seq_Bcells_Human	1.14247963
52	AR_20517297_ChIP-Seq_VCAP_Human	1.13364834
53	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11518161
54	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.10644788
55	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.10123251
56	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.09834001
57	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.09242580
58	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07930088
59	TP53_22573176_ChIP-Seq_HFKS_Human	1.06055605
60	VDR_23849224_ChIP-Seq_CD4+_Human	1.05261982
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05145332
62	CTCF_27219007_Chip-Seq_Bcells_Human	1.04930025
63	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.04907242
64	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04539854
65	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.03916846
66	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.03755101
67	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.03515341
68	STAT1_20625510_ChIP-Seq_HELA_Human	1.03031784
69	P300_27268052_Chip-Seq_Bcells_Human	1.02057911
70	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.01882696
71	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.00227304
72	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.00112981
73	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.99256769
74	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.98335696
75	XRN2_22483619_ChIP-Seq_HELA_Human	0.97574784
76	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.97349300
77	P68_20966046_ChIP-Seq_HELA_Human	0.97322755
78	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.96563363
79	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.96077789
80	NCOR_22424771_ChIP-Seq_293T_Human	0.95855620
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95845355
82	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.95747148
83	SOX2_21211035_ChIP-Seq_LN229_Human	0.94329860
84	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.93843251
85	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.93272389
86	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90729361
87	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.89476804
88	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.88699952
89	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.87376291
90	MAF_26560356_Chip-Seq_TH2_Human	0.87082741
91	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.87047457
92	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.86706465
93	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.86347096
94	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.85797764
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.85144343
96	E2F1_20622854_ChIP-Seq_HELA_Human	0.85061776
97	TTF2_22483619_ChIP-Seq_HELA_Human	0.84656532
98	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.84461330
99	PHF8_20622854_ChIP-Seq_HELA_Human	0.84397012
100	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.83697450

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.49226562
2	MP0004742_abnormal_vestibular_system	3.17640221
3	MP0003646_muscle_fatigue	2.83956526
4	MP0005671_abnormal_response_to	2.77066304
5	MP0002653_abnormal_ependyma_morphology	2.76901037
6	MP0005360_urolithiasis	2.63033930
7	MP0004142_abnormal_muscle_tone	2.61062924
8	MP0002163_abnormal_gland_morphology	2.60177965
9	MP0003123_paternal_imprinting	2.57820393
10	MP0001485_abnormal_pinna_reflex	2.36147675
11	MP0003693_abnormal_embryo_hatching	2.23647118
12	MP0001501_abnormal_sleep_pattern	2.19588364
13	MP0003787_abnormal_imprinting	2.19333144
14	MP0001835_abnormal_antigen_presentation	2.08397199
15	MP0005423_abnormal_somatic_nervous	2.03158718
16	MP0004145_abnormal_muscle_electrophysio	1.92500732
17	MP0003806_abnormal_nucleotide_metabolis	1.83441357
18	MP0003436_decreased_susceptibility_to	1.80191228
19	MP0009333_abnormal_splenocyte_physiolog	1.72385567
20	MP0001800_abnormal_humoral_immune	1.70915264
21	MP0000685_abnormal_immune_system	1.64901187
22	MP0010155_abnormal_intestine_physiology	1.62409545
23	MP0002148_abnormal_hypersensitivity_rea	1.62346516
24	MP0003878_abnormal_ear_physiology	1.60811188
25	MP0005377_hearing/vestibular/ear_phenot	1.60811188
26	MP0003866_abnormal_defecation	1.59157183
27	MP0005085_abnormal_gallbladder_physiolo	1.58626517
28	MP0002102_abnormal_ear_morphology	1.52083370
29	MP0005379_endocrine/exocrine_gland_phen	1.51928383
30	MP0009764_decreased_sensitivity_to	1.50659558
31	MP0006292_abnormal_olfactory_placode	1.50559439
32	MP0001790_abnormal_immune_system	1.48350958
33	MP0005387_immune_system_phenotype	1.48350958
34	MP0002272_abnormal_nervous_system	1.45335309
35	MP0001666_abnormal_nutrient_absorption	1.43656572
36	MP0001502_abnormal_circadian_rhythm	1.42236245
37	MP0001440_abnormal_grooming_behavior	1.42032653
38	MP0008872_abnormal_physiological_respon	1.36654162
39	MP0001765_abnormal_ion_homeostasis	1.35876843
40	MP0004043_abnormal_pH_regulation	1.32753460
41	MP0005645_abnormal_hypothalamus_physiol	1.32004331
42	MP0002723_abnormal_immune_serum	1.29320773
43	MP0008875_abnormal_xenobiotic_pharmacok	1.24951268
44	MP0009745_abnormal_behavioral_response	1.21187196
45	MP0003763_abnormal_thymus_physiology	1.21003797
46	MP0004019_abnormal_vitamin_homeostasis	1.19693152
47	MP0004147_increased_porphyrin_level	1.18789338
48	MP0002139_abnormal_hepatobiliary_system	1.18087113
49	MP0002420_abnormal_adaptive_immunity	1.16493649
50	MP0004885_abnormal_endolymph	1.15799063
51	MP0005000_abnormal_immune_tolerance	1.14028095
52	MP0001819_abnormal_immune_cell	1.13569841
53	MP0001905_abnormal_dopamine_level	1.13273217
54	MP0002095_abnormal_skin_pigmentation	1.13161751
55	MP0001986_abnormal_taste_sensitivity	1.12737694
56	MP0002067_abnormal_sensory_capabilities	1.12337444
57	MP0001873_stomach_inflammation	1.08790472
58	MP0008789_abnormal_olfactory_epithelium	1.08499978
59	MP0005389_reproductive_system_phenotype	1.06447667
60	MP0009643_abnormal_urine_homeostasis	1.05946420
61	MP0005025_abnormal_response_to	1.05517443
62	MP0001727_abnormal_embryo_implantation	1.04908447
63	MP0000015_abnormal_ear_pigmentation	1.04347536
64	MP0000750_abnormal_muscle_regeneration	1.03937144
65	MP0008004_abnormal_stomach_pH	1.03685812
66	MP0001486_abnormal_startle_reflex	1.02178187
67	MP0009785_altered_susceptibility_to	1.01466103
68	MP0001663_abnormal_digestive_system	1.01458424
69	MP0002160_abnormal_reproductive_system	1.00964497
70	MP0000372_irregular_coat_pigmentation	1.00739087
71	MP0005551_abnormal_eye_electrophysiolog	1.00500241
72	MP0001968_abnormal_touch/_nociception	0.99778527
73	MP0006276_abnormal_autonomic_nervous	0.99260295
74	MP0002452_abnormal_antigen_presenting	0.97678195
75	MP0001970_abnormal_pain_threshold	0.97547012
76	MP0001845_abnormal_inflammatory_respons	0.96241791
77	MP0000026_abnormal_inner_ear	0.95553834
78	MP0001919_abnormal_reproductive_system	0.95124323
79	MP0005636_abnormal_mineral_homeostasis	0.93415277
80	MP0002138_abnormal_hepatobiliary_system	0.92875084
81	MP0002638_abnormal_pupillary_reflex	0.92698566
82	MP0000778_abnormal_nervous_system	0.91080997
83	MP0005174_abnormal_tail_pigmentation	0.90223988
84	MP0003890_abnormal_embryonic-extraembry	0.90220092
85	MP0003252_abnormal_bile_duct	0.89028375
86	MP0004957_abnormal_blastocyst_morpholog	0.87890390
87	MP0002876_abnormal_thyroid_physiology	0.85852844
88	MP0002557_abnormal_social/conspecific_i	0.84494288
89	MP0003638_abnormal_response/metabolism_	0.82954322
90	MP0000538_abnormal_urinary_bladder	0.82700920
91	MP0003183_abnormal_peptide_metabolism	0.82040581
92	MP0002136_abnormal_kidney_physiology	0.81834573
93	MP0008877_abnormal_DNA_methylation	0.80803860
94	MP0003879_abnormal_hair_cell	0.80341922
95	MP0000716_abnormal_immune_system	0.79558394
96	MP0002229_neurodegeneration	0.79429825
97	MP0005448_abnormal_energy_balance	0.77608813
98	MP0002736_abnormal_nociception_after	0.76248464
99	MP0005332_abnormal_amino_acid	0.74761158
100	MP0002735_abnormal_chemical_nociception	0.74212430

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.97748477
2	Stomatitis (HP:0010280)	4.27008038
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.14906697
4	Elevated erythrocyte sedimentation rate (HP:0003565)	4.10403660
5	Molar tooth sign on MRI (HP:0002419)	3.82861721
6	Abnormality of midbrain morphology (HP:0002418)	3.82861721
7	Macrocytic anemia (HP:0001972)	3.51372065
8	Pendular nystagmus (HP:0012043)	3.35423480
9	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.28564876
10	Abnormal number of erythroid precursors (HP:0012131)	3.25242878
11	Acute necrotizing encephalopathy (HP:0006965)	3.08166252
12	Confusion (HP:0001289)	3.06825856
13	Abnormality of magnesium homeostasis (HP:0004921)	3.02597598
14	Abnormal mitochondria in muscle tissue (HP:0008316)	2.94250591
15	T lymphocytopenia (HP:0005403)	2.91676130
16	Pancreatic cysts (HP:0001737)	2.86467314
17	Abnormality of T cell number (HP:0011839)	2.84017360
18	Posterior subcapsular cataract (HP:0007787)	2.81533080
19	Abnormality of alanine metabolism (HP:0010916)	2.79207888
20	Hyperalaninemia (HP:0003348)	2.79207888
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.79207888
22	Abnormality of T cells (HP:0002843)	2.66233806
23	Hypomagnesemia (HP:0002917)	2.64276840
24	Abnormality of DNA repair (HP:0003254)	2.61315756
25	IgG deficiency (HP:0004315)	2.60907142
26	Chorioretinal atrophy (HP:0000533)	2.60531608
27	Acute encephalopathy (HP:0006846)	2.60238973
28	Chronic diarrhea (HP:0002028)	2.57405190
29	Pallor (HP:0000980)	2.52861731
30	Increased IgM level (HP:0003496)	2.52192738
31	Methylmalonic aciduria (HP:0012120)	2.51450938
32	Increased circulating renin level (HP:0000848)	2.51124006
33	Tetany (HP:0001281)	2.50642141
34	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.47804888
35	Abolished electroretinogram (ERG) (HP:0000550)	2.47295731
36	Metabolic alkalosis (HP:0200114)	2.45987546
37	Pancreatic fibrosis (HP:0100732)	2.45734758
38	Increased intramyocellular lipid droplets (HP:0012240)	2.42661285
39	3-Methylglutaconic aciduria (HP:0003535)	2.41690002
40	Metaphyseal dysplasia (HP:0100255)	2.40793963
41	Polydipsia (HP:0001959)	2.34579819
42	Abnormal drinking behavior (HP:0030082)	2.34579819
43	Progressive macrocephaly (HP:0004481)	2.33353683
44	Abnormality of T cell physiology (HP:0011840)	2.33146457
45	Mitochondrial inheritance (HP:0001427)	2.32900541
46	Abnormal rod and cone electroretinograms (HP:0008323)	2.30794282
47	Hypoplasia of the radius (HP:0002984)	2.30182376
48	Microretrognathia (HP:0000308)	2.25183234
49	Myokymia (HP:0002411)	2.22301612
50	Hypoplasia of the ulna (HP:0003022)	2.20493771
51	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.19174985
52	Congenital sensorineural hearing impairment (HP:0008527)	2.18182619
53	Hyperlipoproteinemia (HP:0010980)	2.14239474
54	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.13333866
55	Type II lissencephaly (HP:0007260)	2.13178075
56	Hypokalemic alkalosis (HP:0001949)	2.09654972
57	Increased muscle lipid content (HP:0009058)	2.07603507
58	Abnormal hemoglobin (HP:0011902)	2.07208032
59	Retinal dysplasia (HP:0007973)	2.05123001
60	Abnormality of the renal cortex (HP:0011035)	2.03458277
61	Keratoconus (HP:0000563)	2.01344695
62	Increased corneal curvature (HP:0100692)	2.01344695
63	Forearm undergrowth (HP:0009821)	1.98094781
64	Abnormality of renin-angiotensin system (HP:0000847)	1.96392928
65	Abnormality of vitamin B metabolism (HP:0004340)	1.95902400
66	Neoplasm of the adrenal cortex (HP:0100641)	1.95694476
67	Neutropenia (HP:0001875)	1.95526390
68	Abnormality of reticulocytes (HP:0004312)	1.95404273
69	Colon cancer (HP:0003003)	1.93741927
70	Cerebellar dysplasia (HP:0007033)	1.93663300
71	Increased CSF lactate (HP:0002490)	1.93084277
72	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.91987400
73	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.91987400
74	Congenital stationary night blindness (HP:0007642)	1.91656426
75	Epidermoid cyst (HP:0200040)	1.91071514
76	Oligodactyly (hands) (HP:0001180)	1.90195025
77	Alkalosis (HP:0001948)	1.89214707
78	Gastrointestinal infarctions (HP:0005244)	1.88066910
79	Cystic liver disease (HP:0006706)	1.87859207
80	Fair hair (HP:0002286)	1.87802769
81	Cerebral edema (HP:0002181)	1.86975046
82	Intestinal atresia (HP:0011100)	1.86882831
83	Agitation (HP:0000713)	1.85894445
84	Chronic hepatic failure (HP:0100626)	1.84287281
85	Thyroiditis (HP:0100646)	1.82435580
86	Abnormality of urine glucose concentration (HP:0011016)	1.82232494
87	Glycosuria (HP:0003076)	1.82232494
88	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.80592128
89	Hepatoblastoma (HP:0002884)	1.78936600
90	Chronic mucocutaneous candidiasis (HP:0002728)	1.78797596
91	Recurrent cutaneous fungal infections (HP:0011370)	1.78797596
92	Hyperglycinemia (HP:0002154)	1.78467333
93	Depressed nasal ridge (HP:0000457)	1.77998834
94	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.76942071
95	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.76672405
96	Increased serum lactate (HP:0002151)	1.76457121
97	Renal Fanconi syndrome (HP:0001994)	1.76182729
98	Focal motor seizures (HP:0011153)	1.74729695
99	Abnormality of B cell number (HP:0010975)	1.73254745
100	Methylmalonic acidemia (HP:0002912)	1.72826815

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	4.32358842
2	TXK	3.54737706
3	STK39	3.48764169
4	CDK19	3.46068585
5	TLK1	3.06738553
6	MAP3K12	2.77266808
7	MAP4K1	2.70455162
8	MAP3K11	2.60588829
9	MST4	2.53156438
10	NUAK1	2.24183747
11	DYRK2	2.23662212
12	BUB1	2.17297134
13	PINK1	2.04498716
14	RPS6KA4	1.99232790
15	OXSR1	1.94926473
16	ADRBK2	1.82714361
17	BCKDK	1.82543371
18	CAMK1	1.75596300
19	RIPK4	1.75237825
20	CAMKK2	1.70030494
21	MATK	1.65715497
22	TESK2	1.65516868
23	SCYL2	1.55131320
24	ITK	1.54566598
25	EPHB2	1.53665663
26	TEC	1.48000060
27	CAMKK1	1.46907286
28	PIK3CA	1.43908849
29	BTK	1.35893386
30	NTRK1	1.28153348
31	CAMK4	1.24366786
32	VRK2	1.23496197
33	CDC7	1.22584027
34	BMPR1B	1.19584724
35	KDR	1.19464429
36	MYLK	1.17253551
37	SIK2	1.08837464
38	TAOK3	1.08701617
39	GRK1	1.08376459
40	PASK	1.03123376
41	ACVR1B	1.01297352
42	EPHA4	0.99086315
43	LRRK2	0.94565640
44	SYK	0.93028740
45	HIPK2	0.92273632
46	MAP4K2	0.92233698
47	PAK3	0.91524622
48	GRK5	0.91471158
49	SGK494	0.86780533
50	SGK223	0.86780533
51	DAPK3	0.85876774
52	GRK6	0.81681980
53	IKBKB	0.79763200
54	MARK3	0.79522614
55	PRKCQ	0.78680023
56	RPS6KA5	0.77776764
57	BRAF	0.77680699
58	ZAK	0.72713864
59	WNK1	0.69764844
60	ERBB2	0.69161246
61	WNK3	0.67304181
62	SRPK1	0.65125543
63	PDK2	0.63685799
64	GRK7	0.62927544
65	PIK3CG	0.62843536
66	TRIM28	0.62730977
67	OBSCN	0.62246207
68	LIMK1	0.57614141
69	TIE1	0.56997878
70	MAPKAPK5	0.56555050
71	MAP2K6	0.54069149
72	PRKCZ	0.54003670
73	INSRR	0.53609608
74	LCK	0.53141336
75	TNIK	0.50543507
76	TAF1	0.49632661
77	MAPK13	0.49555032
78	PRKACA	0.49350083
79	ADRBK1	0.49028632
80	PRKCI	0.46721876
81	PRKCA	0.46547678
82	FRK	0.45489342
83	SGK2	0.45404962
84	ZAP70	0.42176561
85	TNK2	0.41557536
86	ILK	0.41096937
87	AKT3	0.39907326
88	PRKCD	0.37053501
89	BMPR2	0.36905519
90	ICK	0.34973065
91	PIM1	0.34590218
92	LYN	0.30705876
93	ABL2	0.30563281
94	NTRK2	0.30518403
95	PRKCG	0.29525707
96	NEK2	0.28541446
97	TRPM7	0.27087395
98	TYRO3	0.26738724
99	CAMK2A	0.26200711
100	CSNK1A1L	0.25771067

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.35929964
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.33275295
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.28668283
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.22264767
5	Linoleic acid metabolism_Homo sapiens_hsa00591	3.15662953
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.03212914
7	Parkinsons disease_Homo sapiens_hsa05012	2.46873570
8	Fat digestion and absorption_Homo sapiens_hsa04975	2.45263538
9	Asthma_Homo sapiens_hsa05310	2.16746343
10	Allograft rejection_Homo sapiens_hsa05330	2.11547085
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.96031288
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.94407876
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.93105076
14	Caffeine metabolism_Homo sapiens_hsa00232	1.84558321
15	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.79886473
16	RNA polymerase_Homo sapiens_hsa03020	1.79861005
17	Proteasome_Homo sapiens_hsa03050	1.79326293
18	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.77128239
19	Alzheimers disease_Homo sapiens_hsa05010	1.76926354
20	Graft-versus-host disease_Homo sapiens_hsa05332	1.74104254
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.74007421
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.63676901
23	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.57993469
24	Type I diabetes mellitus_Homo sapiens_hsa04940	1.56802996
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.52867878
26	Huntingtons disease_Homo sapiens_hsa05016	1.50123114
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.47511769
28	Phototransduction_Homo sapiens_hsa04744	1.44394394
29	Protein export_Homo sapiens_hsa03060	1.42181005
30	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.40749204
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.39450318
32	Retinol metabolism_Homo sapiens_hsa00830	1.38076210
33	Sulfur metabolism_Homo sapiens_hsa00920	1.31540512
34	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.23419211
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.22754160
36	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.20531185
37	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.19708063
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.19088172
39	Peroxisome_Homo sapiens_hsa04146	1.17451941
40	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.15405285
41	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.10151569
42	Glutathione metabolism_Homo sapiens_hsa00480	1.09395577
43	Pyrimidine metabolism_Homo sapiens_hsa00240	1.06623884
44	Collecting duct acid secretion_Homo sapiens_hsa04966	1.03538464
45	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.98117094
46	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.97089784
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.96488975
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.91658913
49	Mineral absorption_Homo sapiens_hsa04978	0.89090403
50	RNA degradation_Homo sapiens_hsa03018	0.86868600
51	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.85815439
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.85645610
53	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.84046163
54	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.81305774
55	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.81155262
56	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.78656585
57	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.73096011
58	Sulfur relay system_Homo sapiens_hsa04122	0.72037974
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.71008155
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.69608848
61	Morphine addiction_Homo sapiens_hsa05032	0.64469026
62	Rheumatoid arthritis_Homo sapiens_hsa05323	0.62358689
63	Arginine and proline metabolism_Homo sapiens_hsa00330	0.61910174
64	Viral myocarditis_Homo sapiens_hsa05416	0.60294176
65	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.59643894
66	Metabolic pathways_Homo sapiens_hsa01100	0.59424527
67	Regulation of autophagy_Homo sapiens_hsa04140	0.58070590
68	Renin-angiotensin system_Homo sapiens_hsa04614	0.54578307
69	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.54082848
70	Nicotine addiction_Homo sapiens_hsa05033	0.53964976
71	Purine metabolism_Homo sapiens_hsa00230	0.53723615
72	Chemokine signaling pathway_Homo sapiens_hsa04062	0.52021722
73	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.50165557
74	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.49876813
75	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46169496
76	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.44040158
77	Olfactory transduction_Homo sapiens_hsa04740	0.39087727
78	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.36383538
79	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.36034005
80	Cocaine addiction_Homo sapiens_hsa05030	0.33356887
81	Bile secretion_Homo sapiens_hsa04976	0.32882629
82	Amphetamine addiction_Homo sapiens_hsa05031	0.31514019
83	Protein digestion and absorption_Homo sapiens_hsa04974	0.31300011
84	Insulin secretion_Homo sapiens_hsa04911	0.30892416
85	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.30280344
86	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.28926746
87	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.28748271
88	Fanconi anemia pathway_Homo sapiens_hsa03460	0.28023807
89	Salmonella infection_Homo sapiens_hsa05132	0.27941508
90	Homologous recombination_Homo sapiens_hsa03440	0.27414593
91	Serotonergic synapse_Homo sapiens_hsa04726	0.26747434
92	Glutamatergic synapse_Homo sapiens_hsa04724	0.25027353
93	Tryptophan metabolism_Homo sapiens_hsa00380	0.24046578
94	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.23980690
95	VEGF signaling pathway_Homo sapiens_hsa04370	0.22527393
96	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.21657655
97	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.20921432
98	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.19428964
99	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.16872473
100	Notch signaling pathway_Homo sapiens_hsa04330	0.16199635

RPL35AP35

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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