RPL35P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)7.44969055
2viral transcription (GO:0019083)7.42529824
3ribosomal small subunit assembly (GO:0000028)7.11804856
4translational termination (GO:0006415)7.05146906
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.33157910
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.22390357
7cotranslational protein targeting to membrane (GO:0006613)6.21857707
8protein targeting to ER (GO:0045047)6.19192771
9translational elongation (GO:0006414)6.15120072
10ATP synthesis coupled proton transport (GO:0015986)6.15104052
11energy coupled proton transport, down electrochemical gradient (GO:0015985)6.15104052
12maturation of SSU-rRNA (GO:0030490)6.10437365
13protein localization to endoplasmic reticulum (GO:0070972)5.89940034
14establishment of protein localization to endoplasmic reticulum (GO:0072599)5.88615780
15viral life cycle (GO:0019058)5.50312933
16ribosomal large subunit biogenesis (GO:0042273)5.36845328
17cellular protein complex disassembly (GO:0043624)5.33773056
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.20225148
19translational initiation (GO:0006413)5.10488057
20chaperone-mediated protein transport (GO:0072321)4.96762019
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.83389969
22NADH dehydrogenase complex assembly (GO:0010257)4.83389969
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.83389969
24proteasome assembly (GO:0043248)4.75243892
25translation (GO:0006412)4.66412415
26DNA deamination (GO:0045006)4.65360210
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.63949505
28exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.62373924
29protein complex biogenesis (GO:0070271)4.60006295
30establishment of protein localization to mitochondrial membrane (GO:0090151)4.46877535
31respiratory electron transport chain (GO:0022904)4.44468109
32protein neddylation (GO:0045116)4.42838085
33protein complex disassembly (GO:0043241)4.41814621
34electron transport chain (GO:0022900)4.38136758
35mitochondrial respiratory chain complex assembly (GO:0033108)4.27897463
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.22506586
37macromolecular complex disassembly (GO:0032984)4.20850487
38ribonucleoprotein complex biogenesis (GO:0022613)4.18838315
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.17140325
40negative regulation of mast cell activation (GO:0033004)4.17109304
41cellular component biogenesis (GO:0044085)4.09847377
42protein targeting to membrane (GO:0006612)4.07354294
43respiratory chain complex IV assembly (GO:0008535)4.07306774
44nuclear-transcribed mRNA catabolic process (GO:0000956)3.99235076
45mRNA catabolic process (GO:0006402)3.78337884
46cytochrome complex assembly (GO:0017004)3.76455209
47pseudouridine synthesis (GO:0001522)3.76326473
48rRNA processing (GO:0006364)3.70789223
49peptidyl-histidine modification (GO:0018202)3.68251023
50maturation of 5.8S rRNA (GO:0000460)3.66854106
51rRNA metabolic process (GO:0016072)3.64939973
52purine nucleoside triphosphate biosynthetic process (GO:0009145)3.63961480
53GTP biosynthetic process (GO:0006183)3.62621122
54deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.60791346
55purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.60070330
56ATP biosynthetic process (GO:0006754)3.59264816
57mannosylation (GO:0097502)3.56568351
58RNA catabolic process (GO:0006401)3.45275223
59water-soluble vitamin biosynthetic process (GO:0042364)3.39672285
60pyrimidine nucleotide catabolic process (GO:0006244)3.39429881
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.37404797
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.37404797
63pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.37287138
64rRNA modification (GO:0000154)3.37033584
65deoxyribonucleotide catabolic process (GO:0009264)3.31978484
66UTP biosynthetic process (GO:0006228)3.26709211
67regulation of activation of Janus kinase activity (GO:0010533)3.19438004
68protein targeting to mitochondrion (GO:0006626)3.17974194
69hydrogen ion transmembrane transport (GO:1902600)3.17109546
70regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.16558134
71ribonucleoside triphosphate biosynthetic process (GO:0009201)3.16517096
72deoxyribose phosphate catabolic process (GO:0046386)3.12162461
73deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.08451194
74transcription elongation from RNA polymerase III promoter (GO:0006385)3.03342489
75termination of RNA polymerase III transcription (GO:0006386)3.03342489
76establishment of protein localization to mitochondrion (GO:0072655)2.98920705
77regulation of mitochondrial translation (GO:0070129)2.97269770
78ncRNA 3-end processing (GO:0043628)2.93380579
79UTP metabolic process (GO:0046051)2.93112580
80formation of translation preinitiation complex (GO:0001731)2.91764636
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91040537
82oxidative phosphorylation (GO:0006119)2.90881165
83regulation of cellular amino acid metabolic process (GO:0006521)2.85588986
84nucleoside triphosphate biosynthetic process (GO:0009142)2.83267103
85purine deoxyribonucleotide catabolic process (GO:0009155)2.82302494
86pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.80540298
87protein targeting (GO:0006605)2.77196845
88protein localization to mitochondrion (GO:0070585)2.76983046
89establishment of protein localization to membrane (GO:0090150)2.76765350
90proton transport (GO:0015992)2.76364731
91purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.76101916
92negative regulation of ligase activity (GO:0051352)2.74811344
93negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.74811344
942-deoxyribonucleotide metabolic process (GO:0009394)2.73363987
95DNA damage response, detection of DNA damage (GO:0042769)2.73205587
96base-excision repair, AP site formation (GO:0006285)2.71990537
97ncRNA processing (GO:0034470)2.71797083
98pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.71505541
99RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.69922533
100hydrogen transport (GO:0006818)2.69419814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.48501417
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.45320826
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.17895243
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.76878484
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.64932720
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.51674272
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.37804244
8EZH2_22144423_ChIP-Seq_EOC_Human3.08411372
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.94183115
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.86129206
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.85867350
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.84930032
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59480888
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57359619
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54907765
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.48289227
17VDR_23849224_ChIP-Seq_CD4+_Human2.44459009
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34740453
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31324606
20FOXP3_21729870_ChIP-Seq_TREG_Human2.27835071
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20780118
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18809852
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.17898203
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16233062
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07753119
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.07710577
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06500457
28ELK1_19687146_ChIP-ChIP_HELA_Human2.05731329
29XRN2_22483619_ChIP-Seq_HELA_Human1.96938212
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.95198676
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.92853824
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83567147
33TTF2_22483619_ChIP-Seq_HELA_Human1.82866787
34IGF1R_20145208_ChIP-Seq_DFB_Human1.78381958
35MYC_18940864_ChIP-ChIP_HL60_Human1.75167899
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.75158249
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.75103535
38GABP_19822575_ChIP-Seq_HepG2_Human1.74980860
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.68224276
40IRF1_19129219_ChIP-ChIP_H3396_Human1.59412798
41ZNF274_21170338_ChIP-Seq_K562_Hela1.49965919
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45103102
43DCP1A_22483619_ChIP-Seq_HELA_Human1.44062233
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41316713
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39950020
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39068177
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36790158
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34308392
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28296629
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27523082
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25782346
52VDR_22108803_ChIP-Seq_LS180_Human1.24597256
53CIITA_25753668_ChIP-Seq_RAJI_Human1.22657629
54TP53_22573176_ChIP-Seq_HFKS_Human1.16638312
55PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15791337
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15760568
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13416475
58EWS_26573619_Chip-Seq_HEK293_Human1.13028774
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11320413
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10698295
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10623767
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.09520034
63YY1_22570637_ChIP-Seq_MALME-3M_Human1.09306061
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06955683
65KDM5A_27292631_Chip-Seq_BREAST_Human1.05803467
66CTCF_20526341_ChIP-Seq_ESCs_Human1.05578667
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04991949
68TAF2_19829295_ChIP-Seq_ESCs_Human1.04886883
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04406621
70ERG_20517297_ChIP-Seq_VCAP_Human1.03629361
71SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03525012
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03352269
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.03352269
74RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02967702
75NCOR_22424771_ChIP-Seq_293T_Human1.02549188
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01284830
77CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99539048
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97092999
79BCL6_27268052_Chip-Seq_Bcells_Human0.96088814
80AR_20517297_ChIP-Seq_VCAP_Human0.95988339
81ELK1_22589737_ChIP-Seq_MCF10A_Human0.94586526
82NANOG_20526341_ChIP-Seq_ESCs_Human0.93379656
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93162230
84EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92031386
85FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91519320
86NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90590891
87ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90108088
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88804568
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88250636
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87708381
91FLI1_27457419_Chip-Seq_LIVER_Mouse0.87224550
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.85543522
93STAT1_20625510_ChIP-Seq_HELA_Human0.83451137
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.82381269
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82257420
96ERA_21632823_ChIP-Seq_H3396_Human0.82114882
97PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81320347
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.81150205
99FOXP1_21924763_ChIP-Seq_HESCs_Human0.80907437
100IRF8_22096565_ChIP-ChIP_GC-B_Human0.79336485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.36446213
2MP0009379_abnormal_foot_pigmentation4.07508377
3MP0003646_muscle_fatigue4.06590084
4MP0002138_abnormal_hepatobiliary_system3.09789232
5MP0005671_abnormal_response_to2.58528118
6MP0004145_abnormal_muscle_electrophysio2.58272215
7MP0008058_abnormal_DNA_repair2.44762694
8MP0003122_maternal_imprinting2.42016915
9MP0003806_abnormal_nucleotide_metabolis2.35270763
10MP0003787_abnormal_imprinting2.24519130
11MP0008877_abnormal_DNA_methylation2.12041260
12MP0006036_abnormal_mitochondrial_physio1.96580443
13MP0003121_genomic_imprinting1.93638862
14MP0003693_abnormal_embryo_hatching1.89880810
15MP0005645_abnormal_hypothalamus_physiol1.78970797
16MP0002163_abnormal_gland_morphology1.78607360
17MP0003186_abnormal_redox_activity1.76598084
18MP0008875_abnormal_xenobiotic_pharmacok1.75537631
19MP0005389_reproductive_system_phenotype1.74074163
20MP0002102_abnormal_ear_morphology1.72135933
21MP0002160_abnormal_reproductive_system1.69271801
22MP0001919_abnormal_reproductive_system1.59124564
23MP0006072_abnormal_retinal_apoptosis1.57570842
24MP0005084_abnormal_gallbladder_morpholo1.55640993
25MP0001968_abnormal_touch/_nociception1.52728032
26MP0000049_abnormal_middle_ear1.50995517
27MP0005083_abnormal_biliary_tract1.50136586
28MP0002653_abnormal_ependyma_morphology1.47759889
29MP0002095_abnormal_skin_pigmentation1.47665434
30MP0003786_premature_aging1.45262033
31MP0008789_abnormal_olfactory_epithelium1.44583362
32MP0001835_abnormal_antigen_presentation1.40683885
33MP0004147_increased_porphyrin_level1.40556920
34MP0004142_abnormal_muscle_tone1.39908144
35MP0004885_abnormal_endolymph1.39377048
36MP0008872_abnormal_physiological_respon1.35440174
37MP0009333_abnormal_splenocyte_physiolog1.29924886
38MP0010094_abnormal_chromosome_stability1.28283242
39MP0005075_abnormal_melanosome_morpholog1.20908026
40MP0001905_abnormal_dopamine_level1.20029318
41MP0005408_hypopigmentation1.19587565
42MP0005646_abnormal_pituitary_gland1.18984944
43MP0004957_abnormal_blastocyst_morpholog1.18025581
44MP0002837_dystrophic_cardiac_calcinosis1.16005590
45MP0000015_abnormal_ear_pigmentation1.12718035
46MP0001800_abnormal_humoral_immune1.09365443
47MP0002736_abnormal_nociception_after1.06696334
48MP0002210_abnormal_sex_determination1.06531080
49MP0005551_abnormal_eye_electrophysiolog1.06413903
50MP0006276_abnormal_autonomic_nervous1.04806461
51MP0001764_abnormal_homeostasis1.04805998
52MP0003111_abnormal_nucleus_morphology1.03985660
53MP0000631_abnormal_neuroendocrine_gland1.01554805
54MP0003880_abnormal_central_pattern1.00169263
55MP0002006_tumorigenesis0.99612362
56MP0002132_abnormal_respiratory_system0.99284226
57MP0001485_abnormal_pinna_reflex0.98042435
58MP0001293_anophthalmia0.94919045
59MP0001929_abnormal_gametogenesis0.94871941
60MP0003878_abnormal_ear_physiology0.93742677
61MP0005377_hearing/vestibular/ear_phenot0.93742677
62MP0002277_abnormal_respiratory_mucosa0.93575359
63MP0002166_altered_tumor_susceptibility0.92188587
64MP0003123_paternal_imprinting0.89726851
65MP0001661_extended_life_span0.88581418
66MP0005379_endocrine/exocrine_gland_phen0.86061407
67MP0004742_abnormal_vestibular_system0.85986421
68MP0004858_abnormal_nervous_system0.85828590
69MP0003077_abnormal_cell_cycle0.85448940
70MP0003567_abnormal_fetal_cardiomyocyte0.84836530
71MP0001348_abnormal_lacrimal_gland0.84337363
72MP0001145_abnormal_male_reproductive0.84144395
73MP0005174_abnormal_tail_pigmentation0.83840730
74MP0002938_white_spotting0.83120374
75MP0002733_abnormal_thermal_nociception0.83101679
76MP0000653_abnormal_sex_gland0.81990933
77MP0000678_abnormal_parathyroid_gland0.81191260
78MP0005394_taste/olfaction_phenotype0.79416209
79MP0005499_abnormal_olfactory_system0.79416209
80MP0001119_abnormal_female_reproductive0.78637221
81MP0000685_abnormal_immune_system0.78536790
82MP0000372_irregular_coat_pigmentation0.78310624
83MP0009764_decreased_sensitivity_to0.77172548
84MP0005000_abnormal_immune_tolerance0.76720594
85MP0001790_abnormal_immune_system0.76464910
86MP0005387_immune_system_phenotype0.76464910
87MP0002420_abnormal_adaptive_immunity0.76084979
88MP0003011_delayed_dark_adaptation0.75603374
89MP0002723_abnormal_immune_serum0.74262191
90MP0005423_abnormal_somatic_nervous0.73590487
91MP0008007_abnormal_cellular_replicative0.72516223
92MP0001324_abnormal_eye_pigmentation0.72408985
93MP0003698_abnormal_male_reproductive0.72298859
94MP0001819_abnormal_immune_cell0.72284411
95MP0008932_abnormal_embryonic_tissue0.70360134
96MP0002272_abnormal_nervous_system0.70268077
97MP0002638_abnormal_pupillary_reflex0.70098698
98MP0003718_maternal_effect0.69741884
99MP0001963_abnormal_hearing_physiology0.69693493
100MP0005670_abnormal_white_adipose0.69513626

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.68870107
23-Methylglutaconic aciduria (HP:0003535)5.17691431
3Abnormal mitochondria in muscle tissue (HP:0008316)5.03705973
4Acute encephalopathy (HP:0006846)4.80073574
5Progressive macrocephaly (HP:0004481)4.62452713
6Mitochondrial inheritance (HP:0001427)4.48859874
7Abnormality of cells of the erythroid lineage (HP:0012130)4.39498470
8Increased CSF lactate (HP:0002490)4.20340157
9Reticulocytopenia (HP:0001896)3.81895762
10Cerebral edema (HP:0002181)3.57787628
11Abnormal number of erythroid precursors (HP:0012131)3.52199575
12Macrocytic anemia (HP:0001972)3.52196417
13Increased hepatocellular lipid droplets (HP:0006565)3.38952163
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.12763889
15Lipid accumulation in hepatocytes (HP:0006561)3.05505513
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.02724502
17Abnormality of alanine metabolism (HP:0010916)3.02724502
18Hyperalaninemia (HP:0003348)3.02724502
19Stenosis of the external auditory canal (HP:0000402)3.00050824
20Pallor (HP:0000980)2.98624984
21Hepatocellular necrosis (HP:0001404)2.97087934
22Hepatic necrosis (HP:0002605)2.96627908
23Aplastic anemia (HP:0001915)2.94571827
24Increased serum lactate (HP:0002151)2.93457262
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.88372470
26Optic disc pallor (HP:0000543)2.75209163
27Renal Fanconi syndrome (HP:0001994)2.72397756
28Severe visual impairment (HP:0001141)2.72014549
29Lactic acidosis (HP:0003128)2.69752910
30Increased intramyocellular lipid droplets (HP:0012240)2.65819638
31Abnormal rod and cone electroretinograms (HP:0008323)2.63423702
32Congenital stationary night blindness (HP:0007642)2.62822132
33Molar tooth sign on MRI (HP:0002419)2.62747950
34Abnormality of midbrain morphology (HP:0002418)2.62747950
35Abnormality of the labia minora (HP:0012880)2.61234445
36Pancreatic cysts (HP:0001737)2.61093215
37Type II lissencephaly (HP:0007260)2.59013902
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52505655
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52505655
40Respiratory failure (HP:0002878)2.49444234
41Lethargy (HP:0001254)2.49352216
42Colon cancer (HP:0003003)2.46384057
43Glycosuria (HP:0003076)2.45953494
44Abnormality of urine glucose concentration (HP:0011016)2.45953494
45Exercise intolerance (HP:0003546)2.42623348
46Type I transferrin isoform profile (HP:0003642)2.38827717
47Leukodystrophy (HP:0002415)2.34078018
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.32700749
49Methylmalonic acidemia (HP:0002912)2.32664882
50Elevated erythrocyte sedimentation rate (HP:0003565)2.32446551
51Absent thumb (HP:0009777)2.30196250
52Methylmalonic aciduria (HP:0012120)2.25657737
53Exertional dyspnea (HP:0002875)2.25513962
54Hyperglycinemia (HP:0002154)2.24825527
55Type 2 muscle fiber atrophy (HP:0003554)2.21606537
56Increased muscle lipid content (HP:0009058)2.16138203
57Pendular nystagmus (HP:0012043)2.14369606
58True hermaphroditism (HP:0010459)2.10723221
59Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.07568828
60Dicarboxylic aciduria (HP:0003215)2.06250822
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06250822
62Nephronophthisis (HP:0000090)2.05099514
63Abnormality of the phalanges of the 5th finger (HP:0004213)2.03832738
64Pancreatic fibrosis (HP:0100732)2.03610257
65Microvesicular hepatic steatosis (HP:0001414)2.02092903
66Cerebellar dysplasia (HP:0007033)2.00784622
67Testicular atrophy (HP:0000029)2.00647461
68Increased serum pyruvate (HP:0003542)1.98311669
69Respiratory difficulties (HP:0002880)1.97857511
70Muscle fiber atrophy (HP:0100295)1.97702054
71Microretrognathia (HP:0000308)1.96050879
72Hyperphosphaturia (HP:0003109)1.94512646
73Progressive microcephaly (HP:0000253)1.92906866
74Hypoplasia of the radius (HP:0002984)1.90471771
75Abnormal protein glycosylation (HP:0012346)1.89419021
76Abnormal glycosylation (HP:0012345)1.89419021
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89419021
78Abnormal protein N-linked glycosylation (HP:0012347)1.89419021
79Pancytopenia (HP:0001876)1.89171839
80X-linked dominant inheritance (HP:0001423)1.88832391
81Carpal bone hypoplasia (HP:0001498)1.84668214
82Triphalangeal thumb (HP:0001199)1.83289681
83Symphalangism affecting the phalanges of the hand (HP:0009773)1.83098884
84Abnormality of renal resorption (HP:0011038)1.82642171
85Abnormality of placental membranes (HP:0011409)1.82600843
86Amniotic constriction ring (HP:0009775)1.82600843
87Polydipsia (HP:0001959)1.81004388
88Abnormal drinking behavior (HP:0030082)1.81004388
89B lymphocytopenia (HP:0010976)1.80387874
90Depressed nasal ridge (HP:0000457)1.77226992
91Abnormality of B cell number (HP:0010975)1.75246632
92Abnormality of the renal cortex (HP:0011035)1.70997726
93Congenital, generalized hypertrichosis (HP:0004540)1.70988494
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.70795670
95Generalized aminoaciduria (HP:0002909)1.69944466
96Polyuria (HP:0000103)1.68271612
97Rib fusion (HP:0000902)1.67053779
98Horseshoe kidney (HP:0000085)1.65222039
99Absent phalangeal crease (HP:0006109)1.64601817
100Panhypogammaglobulinemia (HP:0003139)1.63717875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK193.82115185
2VRK23.73542776
3BCKDK3.60984918
4NEK12.72589165
5ADRBK22.59496640
6NME22.57439834
7TXK2.36937047
8GRK12.27569862
9LIMK12.27096530
10MAP3K122.22379738
11BUB12.21789523
12PDK22.17342664
13KDR2.10171706
14PBK2.07773672
15ZAK1.96437165
16PASK1.90654845
17MAP3K111.84702182
18TAOK31.78370086
19MAP4K11.74656320
20CDK81.69440538
21TESK21.66300928
22SRPK11.62892542
23EIF2AK11.62858669
24NUAK11.62825747
25TLK11.56765320
26MST41.56184478
27PLK41.55128386
28STK161.54571076
29CDC71.49911617
30TIE11.46605086
31DYRK21.43589536
32VRK11.37658675
33CAMKK21.29231254
34WNK41.22303751
35MAP4K21.22137972
36BRSK11.16316763
37LRRK21.11603154
38BMPR1B1.07794236
39PINK11.03771061
40NME11.03650139
41PIK3CA1.00178656
42AURKA0.99421413
43PIK3CG0.98150781
44AURKB0.96920196
45MAPKAPK30.91886971
46TAF10.90851940
47INSRR0.83908565
48MUSK0.81695608
49PLK10.78842361
50CAMKK10.77968172
51DAPK10.70923413
52ADRBK10.70767926
53CCNB10.70665958
54CSNK2A20.70181014
55ITK0.69372106
56DAPK30.66952997
57PRKCG0.66471122
58PIM20.63935322
59RPS6KA50.63399769
60SYK0.63308471
61ABL20.61961091
62ILK0.61121676
63KIT0.59878809
64CSNK2A10.58439467
65WNK30.57811610
66EIF2AK30.56209531
67PRKCQ0.56026110
68PLK20.54938732
69IKBKB0.54608021
70ATR0.52245467
71CAMK10.52228258
72CHEK20.50056685
73OXSR10.49988270
74STK390.47334257
75OBSCN0.46785867
76MYLK0.45938841
77TGFBR10.45535105
78TEC0.44100387
79RIPK40.42670743
80TTK0.42571048
81PLK30.42144722
82PRKCI0.41398298
83FRK0.40952933
84TNK20.40670604
85RPS6KB20.40596948
86FES0.39243727
87PRKACA0.38274708
88CSNK1G30.36618076
89BTK0.36377234
90CLK10.36177249
91WEE10.34710034
92EPHA40.33644202
93LCK0.31934001
94PIM10.31338874
95PRKCA0.30257438
96LYN0.29857691
97MAPKAPK50.29118157
98CSNK1G10.28317523
99CHEK10.28257618
100IRAK40.27298270

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.08836270
2Oxidative phosphorylation_Homo sapiens_hsa001904.09648815
3Parkinsons disease_Homo sapiens_hsa050123.47446377
4Proteasome_Homo sapiens_hsa030503.34868013
5DNA replication_Homo sapiens_hsa030302.66213570
6RNA polymerase_Homo sapiens_hsa030202.46027207
7Protein export_Homo sapiens_hsa030602.43775361
8Huntingtons disease_Homo sapiens_hsa050162.39655189
9Alzheimers disease_Homo sapiens_hsa050102.32433422
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.19310600
11Mismatch repair_Homo sapiens_hsa034302.06549962
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03358726
13Primary immunodeficiency_Homo sapiens_hsa053401.97404902
14Cardiac muscle contraction_Homo sapiens_hsa042601.94039698
15RNA degradation_Homo sapiens_hsa030181.93703927
16One carbon pool by folate_Homo sapiens_hsa006701.90596195
17Pyrimidine metabolism_Homo sapiens_hsa002401.82535293
18Nucleotide excision repair_Homo sapiens_hsa034201.79445347
19Fanconi anemia pathway_Homo sapiens_hsa034601.77782441
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76356279
21Sulfur relay system_Homo sapiens_hsa041221.69886570
22Homologous recombination_Homo sapiens_hsa034401.62803525
23Base excision repair_Homo sapiens_hsa034101.59390652
24Asthma_Homo sapiens_hsa053101.52468455
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.42441847
26Basal transcription factors_Homo sapiens_hsa030221.42078331
27Spliceosome_Homo sapiens_hsa030401.39362504
28Allograft rejection_Homo sapiens_hsa053301.34213556
29Autoimmune thyroid disease_Homo sapiens_hsa053201.26810113
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20364186
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20035619
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16383751
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15166014
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13228230
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06282773
36Nitrogen metabolism_Homo sapiens_hsa009101.05768395
37Folate biosynthesis_Homo sapiens_hsa007901.05194446
38RNA transport_Homo sapiens_hsa030131.04737947
39Pyruvate metabolism_Homo sapiens_hsa006201.03184193
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02389086
41Propanoate metabolism_Homo sapiens_hsa006401.01962304
42Phototransduction_Homo sapiens_hsa047440.98831375
43Peroxisome_Homo sapiens_hsa041460.97966180
44Purine metabolism_Homo sapiens_hsa002300.97916957
45Linoleic acid metabolism_Homo sapiens_hsa005910.95716442
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92891092
47Graft-versus-host disease_Homo sapiens_hsa053320.90600482
48Type I diabetes mellitus_Homo sapiens_hsa049400.89694594
49Vitamin B6 metabolism_Homo sapiens_hsa007500.85062988
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81028516
51Butanoate metabolism_Homo sapiens_hsa006500.78506564
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.78341198
53Retinol metabolism_Homo sapiens_hsa008300.77188891
54Sulfur metabolism_Homo sapiens_hsa009200.76335278
55Metabolic pathways_Homo sapiens_hsa011000.72969127
56Glutathione metabolism_Homo sapiens_hsa004800.72735346
57Antigen processing and presentation_Homo sapiens_hsa046120.71567907
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71091604
59Chemical carcinogenesis_Homo sapiens_hsa052040.68682758
60Arachidonic acid metabolism_Homo sapiens_hsa005900.67644455
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.67174919
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64255460
63Caffeine metabolism_Homo sapiens_hsa002320.64216501
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62995844
65Hematopoietic cell lineage_Homo sapiens_hsa046400.62179144
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59863652
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59407189
68Fatty acid elongation_Homo sapiens_hsa000620.54023488
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50552461
70Tryptophan metabolism_Homo sapiens_hsa003800.49938511
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48930097
72Ether lipid metabolism_Homo sapiens_hsa005650.47541844
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46196235
74N-Glycan biosynthesis_Homo sapiens_hsa005100.44773006
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.44420749
76Regulation of autophagy_Homo sapiens_hsa041400.43920596
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42880436
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42864966
79Olfactory transduction_Homo sapiens_hsa047400.42161399
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41256109
81Systemic lupus erythematosus_Homo sapiens_hsa053220.39806578
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.39200854
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37631259
84Non-homologous end-joining_Homo sapiens_hsa034500.36465121
85Fat digestion and absorption_Homo sapiens_hsa049750.35525659
86Steroid biosynthesis_Homo sapiens_hsa001000.35445084
87Fatty acid degradation_Homo sapiens_hsa000710.33169248
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.32886213
89Rheumatoid arthritis_Homo sapiens_hsa053230.32181095
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29547056
91Cell cycle_Homo sapiens_hsa041100.29427196
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26756048
93Collecting duct acid secretion_Homo sapiens_hsa049660.25904836
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23934782
95Epstein-Barr virus infection_Homo sapiens_hsa051690.23569255
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.21736079
97p53 signaling pathway_Homo sapiens_hsa041150.21708630
98Tyrosine metabolism_Homo sapiens_hsa003500.21608493
99Viral myocarditis_Homo sapiens_hsa054160.19893979
100beta-Alanine metabolism_Homo sapiens_hsa004100.18641640

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