RPL35P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.61901629
2cytidine metabolic process (GO:0046087)7.24150004
3cytidine catabolic process (GO:0006216)7.24150004
4cytidine deamination (GO:0009972)7.24150004
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.63500532
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.27571937
7Arp2/3 complex-mediated actin nucleation (GO:0034314)4.70272456
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.56860311
9ribosomal small subunit assembly (GO:0000028)4.49208852
10actin nucleation (GO:0045010)4.25173692
11deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.19717465
12ATP synthesis coupled proton transport (GO:0015986)4.13890947
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.13890947
14positive thymic T cell selection (GO:0045059)3.91831308
15positive T cell selection (GO:0043368)3.79515196
16positive regulation of B cell differentiation (GO:0045579)3.78222909
17pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.75398045
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.73271192
19respiratory electron transport chain (GO:0022904)3.71655548
20protein complex biogenesis (GO:0070271)3.68820062
21electron transport chain (GO:0022900)3.64952164
22regulation of activation of Janus kinase activity (GO:0010533)3.60142911
23negative T cell selection (GO:0043383)3.58573093
24pyrimidine nucleoside catabolic process (GO:0046135)3.52867990
25purine deoxyribonucleotide catabolic process (GO:0009155)3.43452359
26response to interferon-beta (GO:0035456)3.40197848
27deoxyribonucleotide catabolic process (GO:0009264)3.38314299
28negative regulation by host of viral transcription (GO:0043922)3.37386421
29negative regulation of B cell apoptotic process (GO:0002903)3.37329957
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.31211242
31regulation of cellular amino acid metabolic process (GO:0006521)3.30817779
32mitochondrial respiratory chain complex assembly (GO:0033108)3.28559638
33T cell migration (GO:0072678)3.26566917
34macrophage chemotaxis (GO:0048246)3.26086527
35ribosomal small subunit biogenesis (GO:0042274)3.26033293
36positive regulation of interleukin-8 secretion (GO:2000484)3.24709481
37negative regulation of T cell apoptotic process (GO:0070233)3.23590375
38deoxyribose phosphate catabolic process (GO:0046386)3.23479677
39viral transcription (GO:0019083)3.23144214
40negative regulation of viral genome replication (GO:0045071)3.22006748
41regulation of B cell receptor signaling pathway (GO:0050855)3.21400612
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.19411148
43NADH dehydrogenase complex assembly (GO:0010257)3.19411148
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19411148
45positive regulation of calcium-mediated signaling (GO:0050850)3.17572802
46sequestering of actin monomers (GO:0042989)3.15377966
47cytochrome complex assembly (GO:0017004)3.13562970
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.13399469
49positive regulation of T cell apoptotic process (GO:0070234)3.11115784
50translational termination (GO:0006415)3.10262510
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09750612
52base-excision repair, AP site formation (GO:0006285)3.07808356
53positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.06928024
54pyrimidine nucleotide catabolic process (GO:0006244)3.06839300
55negative regulation of lymphocyte apoptotic process (GO:0070229)3.06548806
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.04938974
57deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.04507144
58positive regulation of T cell mediated cytotoxicity (GO:0001916)3.04220504
59positive regulation of natural killer cell mediated immunity (GO:0002717)3.02197460
60positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.00647425
61chaperone-mediated protein transport (GO:0072321)3.00494737
62signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.98297120
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.98297120
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97615562
65signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.95875384
66signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.95875384
67signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.95875384
68translational elongation (GO:0006414)2.95317999
69SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.94283882
70negative thymic T cell selection (GO:0045060)2.94041661
71protein targeting to ER (GO:0045047)2.93510054
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.93097911
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.93097911
74regulation of B cell differentiation (GO:0045577)2.91328675
75iron-sulfur cluster assembly (GO:0016226)2.90607337
76metallo-sulfur cluster assembly (GO:0031163)2.90607337
77cotranslational protein targeting to membrane (GO:0006613)2.89532863
78antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.89441130
79protein neddylation (GO:0045116)2.89185005
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.87920250
81pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.85838884
82positive regulation of cell killing (GO:0031343)2.84827518
83establishment of protein localization to mitochondrial membrane (GO:0090151)2.84077523
84respiratory chain complex IV assembly (GO:0008535)2.83410536
85immunoglobulin mediated immune response (GO:0016064)2.82702339
86protein localization to endoplasmic reticulum (GO:0070972)2.81836403
87mannosylation (GO:0097502)2.81753190
88thymic T cell selection (GO:0045061)2.79430963
89mast cell activation involved in immune response (GO:0002279)2.79068768
90mast cell degranulation (GO:0043303)2.79068768
91eosinophil chemotaxis (GO:0048245)2.78972730
92positive regulation of prostaglandin secretion (GO:0032308)2.78646418
93signal transduction involved in DNA integrity checkpoint (GO:0072401)2.78318683
94signal transduction involved in DNA damage checkpoint (GO:0072422)2.78318683
95positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77545403
96establishment of protein localization to endoplasmic reticulum (GO:0072599)2.77167268
97regulation of T cell receptor signaling pathway (GO:0050856)2.75058071
98maturation of SSU-rRNA (GO:0030490)2.73368587
99signal transduction involved in cell cycle checkpoint (GO:0072395)2.72941052
100cytolysis (GO:0019835)2.72693915

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.96201929
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.15313655
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.91064212
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.34143162
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.27782243
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.23039443
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14725593
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14272422
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.08274169
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.03422990
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90750532
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.59620434
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52273758
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36638653
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.34002844
16VDR_23849224_ChIP-Seq_CD4+_Human2.24955440
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17261119
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.15321507
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.05663624
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.02849243
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.02359139
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02050774
23MYB_26560356_Chip-Seq_TH2_Human2.01222628
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01136155
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.97389654
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90026842
27FOXP3_21729870_ChIP-Seq_TREG_Human1.81419721
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81300916
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77443404
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68047684
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64362409
32BCL6_27268052_Chip-Seq_Bcells_Human1.60315255
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.60030039
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.53513775
35RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.53480683
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52982062
37CIITA_25753668_ChIP-Seq_RAJI_Human1.49674625
38EZH2_22144423_ChIP-Seq_EOC_Human1.47210072
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46777538
40GATA3_27048872_Chip-Seq_THYMUS_Human1.41757391
41UTX_26944678_Chip-Seq_JUKART_Human1.40978036
42GATA3_26560356_Chip-Seq_TH2_Human1.40832634
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39077490
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36284803
45MYB_26560356_Chip-Seq_TH1_Human1.34179323
46MYC_18940864_ChIP-ChIP_HL60_Human1.33127209
47NANOG_20526341_ChIP-Seq_ESCs_Human1.32418140
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.29911036
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.28890042
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27841912
51YY1_22570637_ChIP-Seq_MALME-3M_Human1.26288557
52RUNX_20019798_ChIP-Seq_JUKART_Human1.26038514
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24855743
54ELK1_19687146_ChIP-ChIP_HELA_Human1.24666859
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.24143837
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.22329290
57MAF_26560356_Chip-Seq_TH2_Human1.22115015
58VDR_22108803_ChIP-Seq_LS180_Human1.21244601
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18944936
60P300_27268052_Chip-Seq_Bcells_Human1.17768839
61TP53_22573176_ChIP-Seq_HFKS_Human1.17157233
62SPI1_23547873_ChIP-Seq_NB4_Human1.16840207
63TAF2_19829295_ChIP-Seq_ESCs_Human1.14487596
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14395963
65FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14271987
66ZNF274_21170338_ChIP-Seq_K562_Hela1.13509518
67PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13406236
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12633148
69AR_20517297_ChIP-Seq_VCAP_Human1.11026985
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10247261
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09932505
72CTCF_20526341_ChIP-Seq_ESCs_Human1.09293075
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07721975
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06499625
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05426953
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04047703
77HTT_18923047_ChIP-ChIP_STHdh_Human1.02192578
78GABP_19822575_ChIP-Seq_HepG2_Human1.02111914
79MAF_26560356_Chip-Seq_TH1_Human1.00629606
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98442230
81IGF1R_20145208_ChIP-Seq_DFB_Human0.97525166
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97195465
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.97195465
84NCOR_22424771_ChIP-Seq_293T_Human0.95758296
85SCL_19346495_ChIP-Seq_HPC-7_Human0.95586867
86ERG_20517297_ChIP-Seq_VCAP_Human0.95456415
87GATA3_21878914_ChIP-Seq_MCF-7_Human0.94832075
88E2F1_20622854_ChIP-Seq_HELA_Human0.94747794
89BCOR_27268052_Chip-Seq_Bcells_Human0.93480418
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92893830
91TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92509625
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92471432
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91428705
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91415697
95ERA_21632823_ChIP-Seq_H3396_Human0.91356462
96SA1_27219007_Chip-Seq_Bcells_Human0.88686460
97MYC_19030024_ChIP-ChIP_MESCs_Mouse0.87879737
98CTCF_26484167_Chip-Seq_Bcells_Mouse0.87403567
99MYC_19829295_ChIP-Seq_ESCs_Human0.86926497
100E2F1_18555785_ChIP-Seq_MESCs_Mouse0.84949198

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.23179752
2MP0001835_abnormal_antigen_presentation3.19087788
3MP0005645_abnormal_hypothalamus_physiol2.85763833
4MP0009785_altered_susceptibility_to2.80419881
5MP0003763_abnormal_thymus_physiology2.58293947
6MP0009333_abnormal_splenocyte_physiolog2.57765943
7MP0000372_irregular_coat_pigmentation2.40316858
8MP0002148_abnormal_hypersensitivity_rea2.37904864
9MP0004147_increased_porphyrin_level2.37854942
10MP0005000_abnormal_immune_tolerance2.36863506
11MP0001800_abnormal_humoral_immune2.26967649
12MP0005025_abnormal_response_to2.25635315
13MP0000685_abnormal_immune_system2.24523896
14MP0009379_abnormal_foot_pigmentation2.16606694
15MP0002420_abnormal_adaptive_immunity2.13881368
16MP0001819_abnormal_immune_cell2.07067944
17MP0005387_immune_system_phenotype2.05035017
18MP0001790_abnormal_immune_system2.05035017
19MP0002723_abnormal_immune_serum2.03109243
20MP0003806_abnormal_nucleotide_metabolis2.01594340
21MP0001873_stomach_inflammation1.96611335
22MP0005075_abnormal_melanosome_morpholog1.96566243
23MP0002452_abnormal_antigen_presenting1.78029347
24MP0003646_muscle_fatigue1.77268512
25MP0006082_CNS_inflammation1.70746092
26MP0002398_abnormal_bone_marrow1.68613260
27MP0000716_abnormal_immune_system1.67360209
28MP0006292_abnormal_olfactory_placode1.62196539
29MP0008872_abnormal_physiological_respon1.60771869
30MP0002166_altered_tumor_susceptibility1.56886752
31MP0003866_abnormal_defecation1.53854811
32MP0008875_abnormal_xenobiotic_pharmacok1.50156045
33MP0001905_abnormal_dopamine_level1.46469756
34MP0000689_abnormal_spleen_morphology1.43619241
35MP0002102_abnormal_ear_morphology1.43500302
36MP0002405_respiratory_system_inflammati1.39994038
37MP0002722_abnormal_immune_system1.36803132
38MP0008058_abnormal_DNA_repair1.34813233
39MP0003786_premature_aging1.34747262
40MP0002419_abnormal_innate_immunity1.34363736
41MP0002429_abnormal_blood_cell1.32982712
42MP0002837_dystrophic_cardiac_calcinosis1.32898405
43MP0002163_abnormal_gland_morphology1.32042235
44MP0005084_abnormal_gallbladder_morpholo1.31507366
45MP0002138_abnormal_hepatobiliary_system1.30675550
46MP0006072_abnormal_retinal_apoptosis1.29441660
47MP0002006_tumorigenesis1.28669679
48MP0005464_abnormal_platelet_physiology1.28501003
49MP0006036_abnormal_mitochondrial_physio1.27124378
50MP0001845_abnormal_inflammatory_respons1.26820934
51MP0001853_heart_inflammation1.26212302
52MP0000703_abnormal_thymus_morphology1.22734886
53MP0002638_abnormal_pupillary_reflex1.21712917
54MP0004145_abnormal_muscle_electrophysio1.20811199
55MP0005646_abnormal_pituitary_gland1.17935583
56MP0001919_abnormal_reproductive_system1.17145558
57MP0003436_decreased_susceptibility_to1.16955868
58MP0005389_reproductive_system_phenotype1.16548536
59MP0010155_abnormal_intestine_physiology1.15744619
60MP0005551_abnormal_eye_electrophysiolog1.15138609
61MP0005083_abnormal_biliary_tract1.14099626
62MP0008877_abnormal_DNA_methylation1.13605015
63MP0002095_abnormal_skin_pigmentation1.11600440
64MP0004142_abnormal_muscle_tone1.07881276
65MP0005410_abnormal_fertilization1.07745881
66MP0003787_abnormal_imprinting1.06449412
67MP0002019_abnormal_tumor_incidence1.01232218
68MP0008469_abnormal_protein_level1.00357690
69MP0009643_abnormal_urine_homeostasis0.94629777
70MP0000465_gastrointestinal_hemorrhage0.93833018
71MP0002933_joint_inflammation0.93601165
72MP0002876_abnormal_thyroid_physiology0.92031869
73MP0005636_abnormal_mineral_homeostasis0.91642544
74MP0009763_increased_sensitivity_to0.91631907
75MP0001485_abnormal_pinna_reflex0.91189726
76MP0003252_abnormal_bile_duct0.90597836
77MP0003878_abnormal_ear_physiology0.90569820
78MP0005377_hearing/vestibular/ear_phenot0.90569820
79MP0008995_early_reproductive_senescence0.90421209
80MP0006276_abnormal_autonomic_nervous0.89665985
81MP0001764_abnormal_homeostasis0.89603767
82MP0002693_abnormal_pancreas_physiology0.88927139
83MP0002160_abnormal_reproductive_system0.88450674
84MP0001968_abnormal_touch/_nociception0.86200766
85MP0003186_abnormal_redox_activity0.83802549
86MP0002277_abnormal_respiratory_mucosa0.83455042
87MP0003011_delayed_dark_adaptation0.81927497
88MP0010386_abnormal_urinary_bladder0.79395249
89MP0004043_abnormal_pH_regulation0.78031019
90MP0003195_calcinosis0.77828286
91MP0005379_endocrine/exocrine_gland_phen0.77277855
92MP0005166_decreased_susceptibility_to0.75773254
93MP0005253_abnormal_eye_physiology0.75422139
94MP0009764_decreased_sensitivity_to0.73425809
95MP0004742_abnormal_vestibular_system0.73177323
96MP0002653_abnormal_ependyma_morphology0.72239345
97MP0001119_abnormal_female_reproductive0.69241696
98MP0008873_increased_physiological_sensi0.67383065
99MP0003448_altered_tumor_morphology0.66274319
100MP0003075_altered_response_to0.65840253

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.67625201
2Mitochondrial inheritance (HP:0001427)4.52790061
3Acute necrotizing encephalopathy (HP:0006965)4.28034349
4Abnormal mitochondria in muscle tissue (HP:0008316)4.14808214
5Elevated erythrocyte sedimentation rate (HP:0003565)4.06341667
6Hepatocellular necrosis (HP:0001404)3.98837268
7Increased CSF lactate (HP:0002490)3.83461201
8Increased intramyocellular lipid droplets (HP:0012240)3.74561243
9IgG deficiency (HP:0004315)3.70896820
10Agammaglobulinemia (HP:0004432)3.66591773
11Increased hepatocellular lipid droplets (HP:0006565)3.59735165
12Acute encephalopathy (HP:0006846)3.55744540
133-Methylglutaconic aciduria (HP:0003535)3.51518089
14Hepatic necrosis (HP:0002605)3.51253706
15Severe combined immunodeficiency (HP:0004430)3.49700694
16Progressive macrocephaly (HP:0004481)3.44630960
17Autoimmune hemolytic anemia (HP:0001890)3.39582607
18Renal Fanconi syndrome (HP:0001994)3.32407853
19T lymphocytopenia (HP:0005403)3.30883066
20Abnormality of T cell number (HP:0011839)3.28574829
21Lipid accumulation in hepatocytes (HP:0006561)3.26302647
22Hypoproteinemia (HP:0003075)3.24652572
23Abnormality of the prostate (HP:0008775)3.21335770
24Congenital stationary night blindness (HP:0007642)3.20319677
25Increased muscle lipid content (HP:0009058)3.20073690
26Abnormality of B cell number (HP:0010975)3.17808559
27Absent rod-and cone-mediated responses on ERG (HP:0007688)3.10354961
28Increased IgM level (HP:0003496)3.07568733
29Cerebral edema (HP:0002181)3.07297461
30B lymphocytopenia (HP:0010976)2.96719893
31Abnormality of T cells (HP:0002843)2.89505435
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.77560166
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.77560166
34Abnormal rod and cone electroretinograms (HP:0008323)2.76997218
35Chronic obstructive pulmonary disease (HP:0006510)2.72096403
36Obstructive lung disease (HP:0006536)2.72096403
37Combined immunodeficiency (HP:0005387)2.65011604
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.61327710
39Meningitis (HP:0001287)2.61011975
40Exertional dyspnea (HP:0002875)2.59933046
41Severe visual impairment (HP:0001141)2.56795690
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.54967700
43Cerebral palsy (HP:0100021)2.51876676
44Abnormality of cells of the erythroid lineage (HP:0012130)2.47098917
45Optic disc pallor (HP:0000543)2.46550009
46Abnormal number of erythroid precursors (HP:0012131)2.46161607
47Pancytopenia (HP:0001876)2.45308948
48Thyroiditis (HP:0100646)2.44759031
49Abnormality of eosinophils (HP:0001879)2.44282176
50Decreased electroretinogram (ERG) amplitude (HP:0000654)2.42788169
51Lactic acidosis (HP:0003128)2.42107476
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40962372
53Increased serum lactate (HP:0002151)2.40379858
54Exercise intolerance (HP:0003546)2.38675506
55Panhypogammaglobulinemia (HP:0003139)2.36738562
56Stomatitis (HP:0010280)2.31835714
57Dicarboxylic aciduria (HP:0003215)2.30304442
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30304442
59Type I transferrin isoform profile (HP:0003642)2.26554964
60Respiratory failure (HP:0002878)2.22045738
61Reduced antithrombin III activity (HP:0001976)2.19108972
62Encephalitis (HP:0002383)2.18626931
63Eosinophilia (HP:0001880)2.15750735
64Reticulocytopenia (HP:0001896)2.13975710
65Lethargy (HP:0001254)2.08238252
66Skin rash (HP:0000988)2.07372016
67Lymphopenia (HP:0001888)2.06996537
68Recurrent bronchitis (HP:0002837)2.06788718
69Recurrent fungal infections (HP:0002841)2.05394078
70Abnormality of T cell physiology (HP:0011840)2.05115403
71Methylmalonic aciduria (HP:0012120)2.04975763
72Hypoalbuminemia (HP:0003073)2.04897675
73Abnormal albumin level (HP:0012116)2.04897675
74Chronic diarrhea (HP:0002028)2.04334182
75Molar tooth sign on MRI (HP:0002419)2.03210743
76Abnormality of midbrain morphology (HP:0002418)2.03210743
77Pancreatic cysts (HP:0001737)2.00025744
78Decreased central vision (HP:0007663)1.95445578
79Abnormality of cells of the lymphoid lineage (HP:0012140)1.94988878
80Leukocytosis (HP:0001974)1.94593477
81Oral leukoplakia (HP:0002745)1.94122232
82Attenuation of retinal blood vessels (HP:0007843)1.94090930
83Abnormal protein glycosylation (HP:0012346)1.93310679
84Abnormal glycosylation (HP:0012345)1.93310679
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93310679
86Abnormal protein N-linked glycosylation (HP:0012347)1.93310679
87Abnormality of renal resorption (HP:0011038)1.92780463
88Chronic mucocutaneous candidiasis (HP:0002728)1.91793268
89Recurrent cutaneous fungal infections (HP:0011370)1.91793268
90Absent thumb (HP:0009777)1.91125888
91Respiratory difficulties (HP:0002880)1.89436029
92Autoimmune thrombocytopenia (HP:0001973)1.89277593
93Abolished electroretinogram (ERG) (HP:0000550)1.87507149
94Hypergammaglobulinemia (HP:0010702)1.87450212
95Mediastinal lymphadenopathy (HP:0100721)1.86272475
96Recurrent viral infections (HP:0004429)1.86263053
97Granulocytopenia (HP:0001913)1.85246969
98Abnormality of male internal genitalia (HP:0000022)1.84088719
99Prostate neoplasm (HP:0100787)1.83907591
100Microvesicular hepatic steatosis (HP:0001414)1.81393517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.43279697
2TESK25.39486502
3VRK24.28293475
4TXK3.99560872
5BCKDK3.75217521
6MAP4K12.46852489
7SCYL22.17279552
8MAP3K112.14786011
9VRK12.05601668
10TESK11.91184573
11TAOK31.90638185
12NUAK11.90170867
13LIMK11.88529655
14ZAK1.86730235
15MAP3K121.82940250
16ADRBK21.73659327
17GRK11.71539272
18MAP4K21.64070876
19TLK11.59619128
20ITK1.58892685
21SYK1.56084658
22PIM21.52957762
23KIT1.45282761
24TAF11.33396773
25TEC1.25836889
26TNK21.25061209
27MST41.22264988
28FES1.19840187
29CCNB11.18336306
30GRK61.15551079
31PRKCQ1.12599087
32DAPK11.11414347
33BTK1.09766953
34CDK191.06326633
35NME21.01918208
36LCK0.94300576
37BUB10.93073709
38MUSK0.92942148
39GRK70.92865630
40LRRK20.89876458
41IKBKB0.87819829
42RPS6KA50.83021323
43MAPKAPK30.82762021
44PIK3CG0.79031856
45DAPK30.78263267
46AURKA0.77842391
47TIE10.77417185
48IKBKE0.76477087
49LYN0.75649283
50WNK40.73714791
51CSK0.72374103
52CSF1R0.68406122
53DYRK20.66687519
54STK160.66652935
55CAMKK20.66545613
56MYLK0.65990150
57ZAP700.65734604
58INSRR0.65086514
59TBK10.62421823
60MATK0.62272624
61ARAF0.61012804
62PIM10.59848864
63NEK20.57654571
64MAPKAPK50.57560242
65IRAK40.57508416
66PINK10.56862751
67ABL20.56492646
68BMPR1B0.55318793
69GRK50.53535794
70JAK30.53276747
71OXSR10.51940668
72MAPK130.50240742
73ADRBK10.46954397
74WNK30.45665188
75PASK0.45579908
76ILK0.45574183
77FRK0.44989825
78TRPM70.44208227
79CDK80.43035496
80DAPK20.42616502
81NME10.41835490
82MAP2K60.41247672
83OBSCN0.41097692
84ATR0.39251319
85CSNK2A20.38979136
86PRKCA0.37969579
87AURKB0.36468267
88CSNK2A10.35488253
89CSNK1G30.34196364
90PRKACA0.34027488
91ROCK10.31771568
92CDC70.29762760
93PRKCD0.28856319
94MAPK150.28684554
95PAK10.28541110
96IGF1R0.28013749
97MAP2K70.26875313
98TAOK20.26270159
99MARK30.25143134
100FYN0.24583537

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.60651029
2Proteasome_Homo sapiens_hsa030504.26508854
3Oxidative phosphorylation_Homo sapiens_hsa001903.74232453
4Ribosome_Homo sapiens_hsa030103.43009109
5Parkinsons disease_Homo sapiens_hsa050123.23103231
6Graft-versus-host disease_Homo sapiens_hsa053322.81498815
7Allograft rejection_Homo sapiens_hsa053302.78188461
8Autoimmune thyroid disease_Homo sapiens_hsa053202.74219199
9Antigen processing and presentation_Homo sapiens_hsa046122.49009673
10Type I diabetes mellitus_Homo sapiens_hsa049402.29397970
11Asthma_Homo sapiens_hsa053102.17645422
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07059639
13Alzheimers disease_Homo sapiens_hsa050102.06769131
14Hematopoietic cell lineage_Homo sapiens_hsa046402.06523274
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.95250227
16RNA polymerase_Homo sapiens_hsa030201.92903427
17Huntingtons disease_Homo sapiens_hsa050161.92032581
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91973376
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.88708103
20Protein export_Homo sapiens_hsa030601.55326927
21Homologous recombination_Homo sapiens_hsa034401.53676049
22Cardiac muscle contraction_Homo sapiens_hsa042601.52769200
23Phototransduction_Homo sapiens_hsa047441.47711719
24Rheumatoid arthritis_Homo sapiens_hsa053231.39603086
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.39063308
26Systemic lupus erythematosus_Homo sapiens_hsa053221.38608774
27Pyrimidine metabolism_Homo sapiens_hsa002401.25574940
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21745206
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19265647
30DNA replication_Homo sapiens_hsa030301.18751069
31T cell receptor signaling pathway_Homo sapiens_hsa046601.13273084
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10806604
33Fanconi anemia pathway_Homo sapiens_hsa034601.05901499
34Base excision repair_Homo sapiens_hsa034101.03862490
35Peroxisome_Homo sapiens_hsa041461.03569392
36Viral myocarditis_Homo sapiens_hsa054161.01248006
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94105204
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89501805
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87453891
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87318762
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85456382
42Butanoate metabolism_Homo sapiens_hsa006500.85008878
43Nucleotide excision repair_Homo sapiens_hsa034200.84769248
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.84543516
45One carbon pool by folate_Homo sapiens_hsa006700.82908277
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81589817
47Mismatch repair_Homo sapiens_hsa034300.81461496
48Purine metabolism_Homo sapiens_hsa002300.80744544
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74380313
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.74302930
51Sulfur metabolism_Homo sapiens_hsa009200.73216901
52Measles_Homo sapiens_hsa051620.73090597
53Linoleic acid metabolism_Homo sapiens_hsa005910.72110010
54Nitrogen metabolism_Homo sapiens_hsa009100.71371115
55RNA degradation_Homo sapiens_hsa030180.70263804
56Sulfur relay system_Homo sapiens_hsa041220.68942321
57Staphylococcus aureus infection_Homo sapiens_hsa051500.66103091
58Propanoate metabolism_Homo sapiens_hsa006400.65972372
59Chemical carcinogenesis_Homo sapiens_hsa052040.65317868
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63406570
61Fatty acid elongation_Homo sapiens_hsa000620.62066026
62Spliceosome_Homo sapiens_hsa030400.62065451
63Caffeine metabolism_Homo sapiens_hsa002320.61451626
64Folate biosynthesis_Homo sapiens_hsa007900.60377948
65Retinol metabolism_Homo sapiens_hsa008300.60177550
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59496203
67Olfactory transduction_Homo sapiens_hsa047400.58581744
68Malaria_Homo sapiens_hsa051440.58181853
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57910263
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57486322
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.55119052
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.53892263
73Metabolic pathways_Homo sapiens_hsa011000.53421950
74Salmonella infection_Homo sapiens_hsa051320.52289125
75Leishmaniasis_Homo sapiens_hsa051400.51469013
76Arachidonic acid metabolism_Homo sapiens_hsa005900.48561656
77Regulation of autophagy_Homo sapiens_hsa041400.46538692
78Shigellosis_Homo sapiens_hsa051310.46101561
79Herpes simplex infection_Homo sapiens_hsa051680.45738508
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45719102
81Basal transcription factors_Homo sapiens_hsa030220.42391246
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.39733654
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39410391
84Tyrosine metabolism_Homo sapiens_hsa003500.37627055
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37198114
86Glutathione metabolism_Homo sapiens_hsa004800.37115810
87Tryptophan metabolism_Homo sapiens_hsa003800.36361386
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35889796
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34439487
90Epstein-Barr virus infection_Homo sapiens_hsa051690.34403639
91Collecting duct acid secretion_Homo sapiens_hsa049660.32809518
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32777117
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32730695
94Alcoholism_Homo sapiens_hsa050340.28562906
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26264319
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22435095
97Ether lipid metabolism_Homo sapiens_hsa005650.17149350
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15479218
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.14287143
100HTLV-I infection_Homo sapiens_hsa051660.14218517

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