ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.26975994
2	ribosomal small subunit assembly (GO:0000028)	7.12661391
3	translational termination (GO:0006415)	7.02589247
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.54489195
5	ATP synthesis coupled proton transport (GO:0015986)	6.54489195
6	ribosomal small subunit biogenesis (GO:0042274)	6.35914251
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.33878376
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.98414876
9	translational elongation (GO:0006414)	5.93268619
10	cotranslational protein targeting to membrane (GO:0006613)	5.91041365
11	protein targeting to ER (GO:0045047)	5.90677246
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.68103549
13	maturation of SSU-rRNA (GO:0030490)	5.64949150
14	protein localization to endoplasmic reticulum (GO:0070972)	5.57714728
15	viral life cycle (GO:0019058)	5.34184753
16	cellular protein complex disassembly (GO:0043624)	5.22270220
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.15405860
18	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.75129878
19	translational initiation (GO:0006413)	4.72363547
20	protein neddylation (GO:0045116)	4.55931731
21	GTP biosynthetic process (GO:0006183)	4.55270157
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.54363887
23	chaperone-mediated protein transport (GO:0072321)	4.51123923
24	respiratory electron transport chain (GO:0022904)	4.45696560
25	electron transport chain (GO:0022900)	4.42590794
26	protein complex disassembly (GO:0043241)	4.41834408
27	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.32005113
28	behavioral response to nicotine (GO:0035095)	4.24437900
29	macromolecular complex disassembly (GO:0032984)	4.24299676
30	DNA deamination (GO:0045006)	4.23244424
31	translation (GO:0006412)	4.18257180
32	ribosomal large subunit biogenesis (GO:0042273)	4.17781427
33	pyrimidine nucleotide catabolic process (GO:0006244)	4.13650140
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.00807790
35	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.00807790
36	NADH dehydrogenase complex assembly (GO:0010257)	4.00807790
37	UTP biosynthetic process (GO:0006228)	3.98687757
38	protein targeting to membrane (GO:0006612)	3.92266693
39	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.89756958
40	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.89756958
41	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.86405470
42	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.83480840
43	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.79724416
44	protein complex biogenesis (GO:0070271)	3.76800648
45	water-soluble vitamin biosynthetic process (GO:0042364)	3.74459675
46	UTP metabolic process (GO:0046051)	3.67733350
47	mRNA catabolic process (GO:0006402)	3.65254172
48	ATP biosynthetic process (GO:0006754)	3.64658727
49	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.53782044
50	ribonucleoprotein complex biogenesis (GO:0022613)	3.53014476
51	cellular component biogenesis (GO:0044085)	3.48848105
52	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.48386397
53	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.47549511
54	hydrogen ion transmembrane transport (GO:1902600)	3.44193316
55	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.38872598
56	RNA catabolic process (GO:0006401)	3.35692749
57	mitochondrial respiratory chain complex assembly (GO:0033108)	3.35608301
58	spliceosomal complex assembly (GO:0000245)	3.25618413
59	cytidine deamination (GO:0009972)	3.24769678
60	cytidine metabolic process (GO:0046087)	3.24769678
61	cytidine catabolic process (GO:0006216)	3.24769678
62	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.19896150
63	CTP metabolic process (GO:0046036)	3.17654993
64	CTP biosynthetic process (GO:0006241)	3.17654993
65	protein K6-linked ubiquitination (GO:0085020)	3.14117338
66	ncRNA 3-end processing (GO:0043628)	3.11286521
67	proton transport (GO:0015992)	3.07152028
68	hydrogen transport (GO:0006818)	3.01506825
69	preassembly of GPI anchor in ER membrane (GO:0016254)	2.99377748
70	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.96910773
71	metallo-sulfur cluster assembly (GO:0031163)	2.94999230
72	iron-sulfur cluster assembly (GO:0016226)	2.94999230
73	ubiquinone biosynthetic process (GO:0006744)	2.93810017
74	nucleoside triphosphate biosynthetic process (GO:0009142)	2.91127816
75	nonmotile primary cilium assembly (GO:0035058)	2.89295293
76	rRNA processing (GO:0006364)	2.89244317
77	chromatin remodeling at centromere (GO:0031055)	2.89193641
78	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.84473934
79	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.84435214
80	rRNA metabolic process (GO:0016072)	2.83317074
81	kinetochore assembly (GO:0051382)	2.80892039
82	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.80353478
83	kidney morphogenesis (GO:0060993)	2.77009269
84	somite development (GO:0061053)	2.75743903
85	regulation of cellular respiration (GO:0043457)	2.75418276
86	guanosine-containing compound biosynthetic process (GO:1901070)	2.75187347
87	mannosylation (GO:0097502)	2.74995470
88	respiratory tube development (GO:0030323)	2.72574970
89	protein-cofactor linkage (GO:0018065)	2.71075079
90	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.69817469
91	termination of RNA polymerase III transcription (GO:0006386)	2.69817469
92	base-excision repair, AP site formation (GO:0006285)	2.67944858
93	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.67639995
94	nucleoside diphosphate phosphorylation (GO:0006165)	2.65981807
95	CENP-A containing nucleosome assembly (GO:0034080)	2.61136817
96	deoxyribonucleotide catabolic process (GO:0009264)	2.60296738
97	protein targeting (GO:0006605)	2.58187670
98	establishment of protein localization to membrane (GO:0090150)	2.57383465
99	rRNA modification (GO:0000154)	2.55665110
100	ubiquinone metabolic process (GO:0006743)	2.52760842

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.87774965
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.83271891
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.14850935
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.81867284
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.77556143
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.64576723
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.17420899
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.09276343
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.05241669
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.01093781
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.72990142
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.42451433
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.28457933
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.21928122
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.13856730
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.10344453
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.10097594
18	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.04909831
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.03720520
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.99971013
21	VDR_22108803_ChIP-Seq_LS180_Human	1.99160082
22	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.93584362
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.89814047
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.84653912
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.81187498
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.73415429
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.66716442
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.65178887
29	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.64272054
30	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.62439529
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.61396030
32	XRN2_22483619_ChIP-Seq_HELA_Human	1.58802174
33	ZNF274_21170338_ChIP-Seq_K562_Hela	1.57719248
34	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.56743974
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51588661
36	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.49750845
37	GABP_19822575_ChIP-Seq_HepG2_Human	1.49035718
38	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.44328966
39	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.42225852
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.34229399
41	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.32920755
42	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.32429235
43	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.31264571
44	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.30212003
45	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.21210412
46	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20559994
47	EWS_26573619_Chip-Seq_HEK293_Human	1.20496823
48	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.18851738
49	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.17780596
50	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.17700688
51	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.17631066
52	NCOR_22424771_ChIP-Seq_293T_Human	1.15247595
53	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.15220250
54	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.12581005
55	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.11977789
56	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.11869057
57	ERA_21632823_ChIP-Seq_H3396_Human	1.09269360
58	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.08972901
59	BCL6_27268052_Chip-Seq_Bcells_Human	1.07358327
60	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05940918
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04836248
62	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03958260
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03391505
64	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.03273251
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02031924
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02031924
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.01867100
68	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.98588063
69	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.98503678
70	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.98383452
71	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98376719
72	MYC_19829295_ChIP-Seq_ESCs_Human	0.97615758
73	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.96643263
74	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.95567982
75	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.94689258
76	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.94656249
77	AR_20517297_ChIP-Seq_VCAP_Human	0.93479987
78	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.93129120
79	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.91913347
80	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.91706917
81	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.90332392
82	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.89385534
83	FUS_26573619_Chip-Seq_HEK293_Human	0.89280607
84	RNF2_27304074_Chip-Seq_NSC_Mouse	0.87961653
85	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.87851266
86	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.87409321
87	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.86940158
88	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.86854554
89	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.86824889
90	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.86731065
91	CIITA_25753668_ChIP-Seq_RAJI_Human	0.86567631
92	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.85633585
93	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.85469292
94	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.85364535
95	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.84296766
96	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.83428444
97	CTCF_20526341_ChIP-Seq_ESCs_Human	0.80983150
98	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.79769179
99	HTT_18923047_ChIP-ChIP_STHdh_Human	0.79714124
100	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.79548574

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.57686662
2	MP0006292_abnormal_olfactory_placode	4.19946107
3	MP0002138_abnormal_hepatobiliary_system	2.83570247
4	MP0004142_abnormal_muscle_tone	2.59227939
5	MP0005377_hearing/vestibular/ear_phenot	2.49356662
6	MP0003878_abnormal_ear_physiology	2.49356662
7	MP0002653_abnormal_ependyma_morphology	2.32916916
8	MP0010030_abnormal_orbit_morphology	2.32553946
9	MP0005645_abnormal_hypothalamus_physiol	2.15619520
10	MP0008058_abnormal_DNA_repair	2.14042455
11	MP0003880_abnormal_central_pattern	2.11051112
12	MP0002102_abnormal_ear_morphology	2.07240964
13	MP0005646_abnormal_pituitary_gland	2.00441211
14	MP0002163_abnormal_gland_morphology	1.96988912
15	MP0004145_abnormal_muscle_electrophysio	1.94908474
16	MP0008877_abnormal_DNA_methylation	1.90180951
17	MP0004885_abnormal_endolymph	1.87473653
18	MP0006276_abnormal_autonomic_nervous	1.85038737
19	MP0008789_abnormal_olfactory_epithelium	1.84916066
20	MP0002938_white_spotting	1.81886455
21	MP0001346_abnormal_lacrimal_gland	1.79478202
22	MP0003122_maternal_imprinting	1.74187695
23	MP0006072_abnormal_retinal_apoptosis	1.73880897
24	MP0003693_abnormal_embryo_hatching	1.71243522
25	MP0008872_abnormal_physiological_respon	1.64613590
26	MP0004742_abnormal_vestibular_system	1.63731048
27	MP0003186_abnormal_redox_activity	1.61313773
28	MP0004147_increased_porphyrin_level	1.61134676
29	MP0001968_abnormal_touch/_nociception	1.57116621
30	MP0008875_abnormal_xenobiotic_pharmacok	1.52991710
31	MP0005671_abnormal_response_to	1.49581392
32	MP0001485_abnormal_pinna_reflex	1.48873380
33	MP0002095_abnormal_skin_pigmentation	1.45597211
34	MP0005084_abnormal_gallbladder_morpholo	1.44624593
35	MP0002160_abnormal_reproductive_system	1.37884833
36	MP0005499_abnormal_olfactory_system	1.31236377
37	MP0005394_taste/olfaction_phenotype	1.31236377
38	MP0003646_muscle_fatigue	1.30230012
39	MP0005389_reproductive_system_phenotype	1.30117201
40	MP0002638_abnormal_pupillary_reflex	1.29310755
41	MP0002272_abnormal_nervous_system	1.24854720
42	MP0005551_abnormal_eye_electrophysiolog	1.23973209
43	MP0001293_anophthalmia	1.23804238
44	MP0003806_abnormal_nucleotide_metabolis	1.22685686
45	MP0002736_abnormal_nociception_after	1.19930196
46	MP0002733_abnormal_thermal_nociception	1.17700926
47	MP0001348_abnormal_lacrimal_gland	1.15312401
48	MP0001970_abnormal_pain_threshold	1.14582805
49	MP0003787_abnormal_imprinting	1.14180171
50	MP0001919_abnormal_reproductive_system	1.13731489
51	MP0001905_abnormal_dopamine_level	1.12524920
52	MP0006036_abnormal_mitochondrial_physio	1.11703646
53	MP0003011_delayed_dark_adaptation	1.09872375
54	MP0002876_abnormal_thyroid_physiology	1.08724063
55	MP0001440_abnormal_grooming_behavior	1.08408813
56	MP0001873_stomach_inflammation	1.06747652
57	MP0005083_abnormal_biliary_tract	1.04420164
58	MP0000015_abnormal_ear_pigmentation	1.03795887
59	MP0002557_abnormal_social/conspecific_i	1.03028477
60	MP0000372_irregular_coat_pigmentation	1.02195681
61	MP0002735_abnormal_chemical_nociception	1.02029954
62	MP0001486_abnormal_startle_reflex	1.00620357
63	MP0003283_abnormal_digestive_organ	1.00454006
64	MP0005423_abnormal_somatic_nervous	0.99429797
65	MP0003121_genomic_imprinting	0.99066668
66	MP0005195_abnormal_posterior_eye	0.99063784
67	MP0002837_dystrophic_cardiac_calcinosis	0.95928240
68	MP0000049_abnormal_middle_ear	0.95413210
69	MP0002210_abnormal_sex_determination	0.94307096
70	MP0009745_abnormal_behavioral_response	0.93155432
71	MP0000685_abnormal_immune_system	0.92479509
72	MP0010094_abnormal_chromosome_stability	0.91641377
73	MP0000778_abnormal_nervous_system	0.90472126
74	MP0004133_heterotaxia	0.86186341
75	MP0000631_abnormal_neuroendocrine_gland	0.85699220
76	MP0001986_abnormal_taste_sensitivity	0.85555007
77	MP0002148_abnormal_hypersensitivity_rea	0.85532561
78	MP0009046_muscle_twitch	0.83980772
79	MP0003786_premature_aging	0.81608866
80	MP0005379_endocrine/exocrine_gland_phen	0.81199420
81	MP0003936_abnormal_reproductive_system	0.80919453
82	MP0005174_abnormal_tail_pigmentation	0.79853337
83	MP0002572_abnormal_emotion/affect_behav	0.79796480
84	MP0001929_abnormal_gametogenesis	0.78832650
85	MP0004957_abnormal_blastocyst_morpholog	0.78107510
86	MP0008775_abnormal_heart_ventricle	0.78062654
87	MP0002752_abnormal_somatic_nervous	0.77849032
88	MP0001835_abnormal_antigen_presentation	0.77408333
89	MP0003123_paternal_imprinting	0.77377902
90	MP0001663_abnormal_digestive_system	0.76966730
91	MP0002822_catalepsy	0.75226924
92	MP0000026_abnormal_inner_ear	0.73847435
93	MP0002067_abnormal_sensory_capabilities	0.73271284
94	MP0001963_abnormal_hearing_physiology	0.71154421
95	MP0005085_abnormal_gallbladder_physiolo	0.69078830
96	MP0001119_abnormal_female_reproductive	0.68670704
97	MP0001800_abnormal_humoral_immune	0.68503744
98	MP0006035_abnormal_mitochondrial_morpho	0.67823186
99	MP0003136_yellow_coat_color	0.67569708
100	MP0001324_abnormal_eye_pigmentation	0.67247313

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.31820066
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.82177785
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.66397657
4	Reticulocytopenia (HP:0001896)	4.66006931
5	Acute encephalopathy (HP:0006846)	4.59665610
6	Mitochondrial inheritance (HP:0001427)	4.32080443
7	Progressive macrocephaly (HP:0004481)	4.28315897
8	Increased CSF lactate (HP:0002490)	3.94012651
9	Abnormal number of erythroid precursors (HP:0012131)	3.78663170
10	Macrocytic anemia (HP:0001972)	3.67742841
11	Molar tooth sign on MRI (HP:0002419)	3.60144854
12	Abnormality of midbrain morphology (HP:0002418)	3.60144854
13	Increased hepatocellular lipid droplets (HP:0006565)	3.54900108
14	Pallor (HP:0000980)	3.40258180
15	Pancreatic fibrosis (HP:0100732)	3.38566353
16	Lipid accumulation in hepatocytes (HP:0006561)	3.35319648
17	Hepatocellular necrosis (HP:0001404)	3.28366126
18	Cerebral edema (HP:0002181)	3.20038833
19	3-Methylglutaconic aciduria (HP:0003535)	3.10580600
20	True hermaphroditism (HP:0010459)	3.07104585
21	Abnormal hemoglobin (HP:0011902)	3.05636307
22	Pancreatic cysts (HP:0001737)	3.02038616
23	Increased intramyocellular lipid droplets (HP:0012240)	3.00712615
24	Hepatic necrosis (HP:0002605)	2.91375471
25	Optic disc pallor (HP:0000543)	2.86971102
26	Renal Fanconi syndrome (HP:0001994)	2.84052502
27	Colon cancer (HP:0003003)	2.81397672
28	Nephronophthisis (HP:0000090)	2.76893844
29	Type II lissencephaly (HP:0007260)	2.70665775
30	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.69262252
31	Absent thumb (HP:0009777)	2.60556899
32	Increased serum lactate (HP:0002151)	2.58684704
33	Increased muscle lipid content (HP:0009058)	2.55321605
34	Abolished electroretinogram (ERG) (HP:0000550)	2.50415442
35	Exertional dyspnea (HP:0002875)	2.43828200
36	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.43768763
37	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.43508453
38	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.43508453
39	Anencephaly (HP:0002323)	2.37989252
40	Leukodystrophy (HP:0002415)	2.36802222
41	Respiratory failure (HP:0002878)	2.35503086
42	Retinal dysplasia (HP:0007973)	2.35196313
43	Medial flaring of the eyebrow (HP:0010747)	2.33155643
44	Lactic acidosis (HP:0003128)	2.33032713
45	Sclerocornea (HP:0000647)	2.32012533
46	Septo-optic dysplasia (HP:0100842)	2.30707836
47	Exercise intolerance (HP:0003546)	2.30069042
48	Cerebellar dysplasia (HP:0007033)	2.28544845
49	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.28041322
50	Hyperglycinemia (HP:0002154)	2.27676785
51	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.26257488
52	Hypoplasia of the radius (HP:0002984)	2.25576724
53	Concave nail (HP:0001598)	2.22768797
54	Congenital, generalized hypertrichosis (HP:0004540)	2.21155995
55	Decreased central vision (HP:0007663)	2.16728717
56	Abnormality of the labia minora (HP:0012880)	2.16682658
57	Lethargy (HP:0001254)	2.15394033
58	Abnormality of the renal medulla (HP:0100957)	2.13735758
59	Cystic liver disease (HP:0006706)	2.11879515
60	Stenosis of the external auditory canal (HP:0000402)	2.11803814
61	Asplenia (HP:0001746)	2.11428802
62	Abnormality of renal resorption (HP:0011038)	2.10691125
63	Polydipsia (HP:0001959)	2.10424025
64	Abnormal drinking behavior (HP:0030082)	2.10424025
65	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.10351664
66	Pendular nystagmus (HP:0012043)	2.09302930
67	Depressed nasal ridge (HP:0000457)	2.06418029
68	Tubular atrophy (HP:0000092)	2.02770830
69	Supernumerary spleens (HP:0009799)	2.02586616
70	IgG deficiency (HP:0004315)	2.02229049
71	Congenital hepatic fibrosis (HP:0002612)	2.01390398
72	Holoprosencephaly (HP:0001360)	1.97590652
73	Abnormality of the renal cortex (HP:0011035)	1.96210092
74	Oligodactyly (hands) (HP:0001180)	1.96104476
75	Forearm undergrowth (HP:0009821)	1.95535805
76	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.94699788
77	Myokymia (HP:0002411)	1.94508324
78	Hypoplasia of the ulna (HP:0003022)	1.89842898
79	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.89188603
80	Abnormality of cochlea (HP:0000375)	1.89133017
81	Abnormality of the anterior horn cell (HP:0006802)	1.85880206
82	Degeneration of anterior horn cells (HP:0002398)	1.85880206
83	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.84199166
84	Congenital stationary night blindness (HP:0007642)	1.83853093
85	Abnormal rod and cone electroretinograms (HP:0008323)	1.83692860
86	Increased IgM level (HP:0003496)	1.83239776
87	Postaxial foot polydactyly (HP:0001830)	1.82235467
88	Rib fusion (HP:0000902)	1.81764055
89	Prostate neoplasm (HP:0100787)	1.81282469
90	Median cleft lip (HP:0000161)	1.75993516
91	Adrenal hypoplasia (HP:0000835)	1.75449370
92	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.75448726
93	Absent/shortened dynein arms (HP:0200106)	1.75448726
94	Male pseudohermaphroditism (HP:0000037)	1.73973269
95	Abnormal number of incisors (HP:0011064)	1.73874154
96	Lissencephaly (HP:0001339)	1.73020709
97	Hyperphosphaturia (HP:0003109)	1.71917869
98	Cleft eyelid (HP:0000625)	1.71708633
99	Maternal diabetes (HP:0009800)	1.71421241
100	Optic nerve hypoplasia (HP:0000609)	1.70634224

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR1B	4.24427906
2	VRK2	3.71469608
3	ZAK	3.50973267
4	CDK8	2.94299579
5	TLK1	2.59406248
6	VRK1	2.54874752
7	BCKDK	2.53689499
8	NUAK1	2.20185163
9	CDC7	2.12959456
10	TXK	2.12857774
11	DYRK2	2.12720299
12	WNK4	2.08840636
13	TGFBR1	2.04149553
14	ADRBK2	2.04049233
15	GRK1	1.73194052
16	TAF1	1.70964295
17	WNK3	1.49752297
18	EPHB2	1.43290551
19	PINK1	1.40050745
20	MUSK	1.33895413
21	EIF2AK1	1.24885819
22	AURKB	1.14940923
23	STK4	1.13188480
24	PLK3	1.10673387
25	PDK2	1.10188020
26	CDK19	1.10159578
27	MST4	1.09734620
28	BUB1	1.07310548
29	GRK5	1.05729885
30	STK39	1.04384475
31	TIE1	1.03080521
32	KDR	1.01400649
33	RPS6KA4	0.98208030
34	CDK9	0.96018885
35	TAOK3	0.95332966
36	GRK7	0.94796710
37	DAPK3	0.91835465
38	LRRK2	0.85842454
39	TEC	0.84254754
40	PLK2	0.83851210
41	AURKA	0.83820107
42	ADRBK1	0.83617202
43	MAP4K2	0.83144404
44	CHEK2	0.82154688
45	NME1	0.81713726
46	INSRR	0.81499227
47	OXSR1	0.80747605
48	PRKCG	0.79876753
49	CDK7	0.79814485
50	NEK1	0.78099577
51	RPS6KA5	0.77531327
52	PLK1	0.77491605
53	PRKCQ	0.76431740
54	ATR	0.75660572
55	FRK	0.72753379
56	PLK4	0.72612492
57	CAMK1	0.72280769
58	CCNB1	0.69795898
59	PIK3CA	0.69486572
60	LIMK1	0.68050564
61	MAP2K7	0.67949917
62	MAP3K11	0.67722371
63	NME2	0.67157713
64	EIF2AK2	0.66832233
65	ITK	0.65625936
66	CSNK2A2	0.63266037
67	EPHA4	0.62807117
68	IKBKB	0.61183235
69	PHKG2	0.60308213
70	PHKG1	0.60308213
71	SYK	0.59766876
72	PKN1	0.57245541
73	PRKACA	0.55759938
74	CSNK2A1	0.55417444
75	MAPK13	0.54671092
76	DAPK1	0.54365196
77	MAP4K1	0.53097664
78	PAK3	0.52862873
79	ABL2	0.50099462
80	STK11	0.47188777
81	CSNK1G3	0.45743136
82	CSNK1A1	0.45685781
83	CSNK1G2	0.45476182
84	MELK	0.45452866
85	BCR	0.44938450
86	PBK	0.44834030
87	ILK	0.44425354
88	PIM1	0.44369433
89	CSNK1E	0.43039699
90	ATM	0.41067471
91	OBSCN	0.41015465
92	RPS6KA6	0.40970867
93	PRKCE	0.40804339
94	PRKCD	0.40291747
95	CAMK2A	0.40258853
96	DYRK1B	0.39608550
97	STK16	0.37068695
98	MAP3K4	0.36995201
99	PRKCA	0.36804907
100	CAMKK2	0.36639937

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.92283778
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.32030662
3	Parkinsons disease_Homo sapiens_hsa05012	3.75609221
4	Proteasome_Homo sapiens_hsa03050	3.05860274
5	Huntingtons disease_Homo sapiens_hsa05016	2.60290409
6	Alzheimers disease_Homo sapiens_hsa05010	2.38774210
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.37050157
8	Mismatch repair_Homo sapiens_hsa03430	2.27686933
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.15643288
10	Homologous recombination_Homo sapiens_hsa03440	2.12378064
11	RNA polymerase_Homo sapiens_hsa03020	2.12128103
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.10444794
13	Protein export_Homo sapiens_hsa03060	2.06924558
14	DNA replication_Homo sapiens_hsa03030	2.04514141
15	Sulfur relay system_Homo sapiens_hsa04122	1.73144956
16	Base excision repair_Homo sapiens_hsa03410	1.72221703
17	One carbon pool by folate_Homo sapiens_hsa00670	1.69643332
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.69486963
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.68486260
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.65893678
21	RNA degradation_Homo sapiens_hsa03018	1.60737564
22	Asthma_Homo sapiens_hsa05310	1.52384533
23	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.44558201
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.40708499
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.36588863
26	Basal transcription factors_Homo sapiens_hsa03022	1.29555669
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.29461153
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.26512076
29	Butanoate metabolism_Homo sapiens_hsa00650	1.23052767
30	Allograft rejection_Homo sapiens_hsa05330	1.21380106
31	Propanoate metabolism_Homo sapiens_hsa00640	1.15945292
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.12168091
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.06473158
34	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.05928245
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.05431425
36	Fatty acid elongation_Homo sapiens_hsa00062	1.05318131
37	Peroxisome_Homo sapiens_hsa04146	1.02983359
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.00681795
39	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.98212620
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.97654107
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.95676042
42	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.93359320
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.93310969
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.87700144
45	Caffeine metabolism_Homo sapiens_hsa00232	0.86787432
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.86764536
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.85630844
48	Folate biosynthesis_Homo sapiens_hsa00790	0.83731611
49	Purine metabolism_Homo sapiens_hsa00230	0.81847073
50	Phototransduction_Homo sapiens_hsa04744	0.79794235
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.73010070
52	Metabolic pathways_Homo sapiens_hsa01100	0.72633894
53	Pyruvate metabolism_Homo sapiens_hsa00620	0.71605113
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71073575
55	RNA transport_Homo sapiens_hsa03013	0.69232599
56	Graft-versus-host disease_Homo sapiens_hsa05332	0.68863277
57	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67777320
58	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.64588993
59	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.64102695
60	Nicotine addiction_Homo sapiens_hsa05033	0.63969963
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.63842322
62	Spliceosome_Homo sapiens_hsa03040	0.62764714
63	Basal cell carcinoma_Homo sapiens_hsa05217	0.61449252
64	Fatty acid degradation_Homo sapiens_hsa00071	0.61309078
65	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.57751867
66	Retinol metabolism_Homo sapiens_hsa00830	0.57674228
67	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57473988
68	Type I diabetes mellitus_Homo sapiens_hsa04940	0.57174142
69	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.56506448
70	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.56260244
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55430947
72	Sulfur metabolism_Homo sapiens_hsa00920	0.55380862
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.55220221
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54693851
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54200185
76	Regulation of autophagy_Homo sapiens_hsa04140	0.51107081
77	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.47659354
78	Non-homologous end-joining_Homo sapiens_hsa03450	0.47233472
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.44870136
80	Fatty acid metabolism_Homo sapiens_hsa01212	0.44823005
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.44811525
82	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.42936392
83	Ether lipid metabolism_Homo sapiens_hsa00565	0.42860935
84	Rheumatoid arthritis_Homo sapiens_hsa05323	0.41671119
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41266933
86	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40899014
87	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.40147942
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37985425
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37232995
90	Olfactory transduction_Homo sapiens_hsa04740	0.35309545
91	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.34411615
92	Steroid biosynthesis_Homo sapiens_hsa00100	0.33472984
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.33003935
94	Morphine addiction_Homo sapiens_hsa05032	0.32078750
95	Glutathione metabolism_Homo sapiens_hsa00480	0.31375975
96	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.27402352
97	beta-Alanine metabolism_Homo sapiens_hsa00410	0.26862887
98	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.22017081
99	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.20379107
100	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.19577418

RPL35P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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