RPL35P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)7.86381225
2cytidine deamination (GO:0009972)7.86381225
3cytidine metabolic process (GO:0046087)7.86381225
4DNA deamination (GO:0045006)7.17749222
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.98530520
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.84039591
7ribosomal small subunit assembly (GO:0000028)5.40123009
8response to gravity (GO:0009629)5.03289630
9viral transcription (GO:0019083)4.57931414
10ATP synthesis coupled proton transport (GO:0015986)4.45301692
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.45301692
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.44104709
13translational termination (GO:0006415)4.35712598
14ribosomal small subunit biogenesis (GO:0042274)4.30325220
15protein complex biogenesis (GO:0070271)4.18693831
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.10794751
17translational elongation (GO:0006414)4.04524187
18pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.97971537
19skeletal muscle adaptation (GO:0043501)3.97546107
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.94315645
21striated muscle atrophy (GO:0014891)3.93645129
22skeletal muscle tissue regeneration (GO:0043403)3.88792086
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.83521012
24protein targeting to ER (GO:0045047)3.81754869
25respiratory electron transport chain (GO:0022904)3.79394684
26cotranslational protein targeting to membrane (GO:0006613)3.77882534
27negative regulation of muscle hypertrophy (GO:0014741)3.76415465
28actin-myosin filament sliding (GO:0033275)3.74071312
29muscle filament sliding (GO:0030049)3.74071312
30electron transport chain (GO:0022900)3.73932563
31muscle atrophy (GO:0014889)3.73440080
32mitochondrial respiratory chain complex assembly (GO:0033108)3.69846697
33chaperone-mediated protein transport (GO:0072321)3.68277264
34sequestering of actin monomers (GO:0042989)3.66996715
35maturation of SSU-rRNA (GO:0030490)3.65799426
36regulation of skeletal muscle contraction (GO:0014819)3.65191299
37pyrimidine nucleoside catabolic process (GO:0046135)3.61456769
38protein localization to endoplasmic reticulum (GO:0070972)3.60759729
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.60575078
40behavioral response to nicotine (GO:0035095)3.59703299
41protein neddylation (GO:0045116)3.50881271
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.47613140
43NADH dehydrogenase complex assembly (GO:0010257)3.47613140
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47613140
45positive regulation of T cell apoptotic process (GO:0070234)3.47008444
46positive regulation of translational initiation (GO:0045948)3.31109464
47positive regulation of calcium-mediated signaling (GO:0050850)3.27778973
48pyrimidine nucleotide catabolic process (GO:0006244)3.27415242
49viral life cycle (GO:0019058)3.22278905
50cellular protein complex disassembly (GO:0043624)3.21055031
51water-soluble vitamin biosynthetic process (GO:0042364)3.18971457
52protein polyglutamylation (GO:0018095)3.15233699
53positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.13753436
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.11655701
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.11655701
56pyrimidine-containing compound catabolic process (GO:0072529)3.10197208
57cytolysis (GO:0019835)3.06832065
58negative regulation by host of viral transcription (GO:0043922)3.05815879
59Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05044432
60positive regulation of B cell differentiation (GO:0045579)3.02193114
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.01509843
62positive regulation of natural killer cell mediated immunity (GO:0002717)3.01358386
63translation (GO:0006412)2.99872722
64positive regulation of interleukin-8 secretion (GO:2000484)2.97181873
65positive T cell selection (GO:0043368)2.96987528
66regulation of chronic inflammatory response (GO:0002676)2.96315149
67regulation of activation of Janus kinase activity (GO:0010533)2.94977090
68cytochrome complex assembly (GO:0017004)2.93397659
69DNA demethylation (GO:0080111)2.92832317
70translational initiation (GO:0006413)2.92002801
71pseudouridine synthesis (GO:0001522)2.89457071
72negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.87285133
73ubiquinone biosynthetic process (GO:0006744)2.86788124
74platelet dense granule organization (GO:0060155)2.85617550
75positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.85298518
76actin-mediated cell contraction (GO:0070252)2.84649761
77positive thymic T cell selection (GO:0045059)2.83532951
78actin nucleation (GO:0045010)2.83171079
79response to muscle activity (GO:0014850)2.83046712
80regulation of cellular amino acid metabolic process (GO:0006521)2.81709798
81negative regulation of organelle assembly (GO:1902116)2.77667932
82pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.76233833
83T cell migration (GO:0072678)2.73173782
84cellular component biogenesis (GO:0044085)2.70209069
85hydrogen ion transmembrane transport (GO:1902600)2.68160170
86regulation of calcium-mediated signaling (GO:0050848)2.67101139
87positive regulation of lymphocyte apoptotic process (GO:0070230)2.65015142
88regulation of B cell differentiation (GO:0045577)2.64941807
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.64552823
90negative T cell selection (GO:0043383)2.63476664
91DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.63075231
92eosinophil chemotaxis (GO:0048245)2.62436159
93regulation of leukocyte mediated cytotoxicity (GO:0001910)2.62157453
94negative regulation of viral genome replication (GO:0045071)2.61478034
95positive regulation of defense response to virus by host (GO:0002230)2.61215697
96regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.60799183
97regulation of natural killer cell mediated immunity (GO:0002715)2.60799183
98ATP biosynthetic process (GO:0006754)2.60795509
99rRNA modification (GO:0000154)2.60350097
100positive regulation of cell killing (GO:0031343)2.60253725

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.82104099
2VDR_22108803_ChIP-Seq_LS180_Human4.66193094
3EZH2_22144423_ChIP-Seq_EOC_Human4.45747698
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.13044292
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.10130953
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.96408097
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.93774769
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.74638260
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71060276
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68358322
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.66856357
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30189790
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28468744
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07306995
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03661236
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.96104785
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.95256171
18CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.95131212
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88009047
20VDR_23849224_ChIP-Seq_CD4+_Human1.75861070
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74753749
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.72178159
23TAF15_26573619_Chip-Seq_HEK293_Human1.64773887
24ZNF274_21170338_ChIP-Seq_K562_Hela1.64159495
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61474248
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.59113587
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56671007
28TP53_22573176_ChIP-Seq_HFKS_Human1.54140831
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47838714
30FOXP3_21729870_ChIP-Seq_TREG_Human1.43582101
31EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.42952417
32RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39679089
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38120873
34NANOG_20526341_ChIP-Seq_ESCs_Human1.35602383
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35003179
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34161727
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.32096577
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30527530
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30507912
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30494978
41CIITA_25753668_ChIP-Seq_RAJI_Human1.29014218
42IGF1R_20145208_ChIP-Seq_DFB_Human1.26650061
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25285309
44CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.25080725
45NCOR_22424771_ChIP-Seq_293T_Human1.24065651
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23661084
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21644324
48MYC_18940864_ChIP-ChIP_HL60_Human1.21022603
49AR_20517297_ChIP-Seq_VCAP_Human1.20436471
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.19839046
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.19460010
52MYB_26560356_Chip-Seq_TH2_Human1.18700987
53ERA_21632823_ChIP-Seq_H3396_Human1.18457242
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18029765
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.17980248
56MYC_19829295_ChIP-Seq_ESCs_Human1.17508305
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16530349
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.16081152
59TAF2_19829295_ChIP-Seq_ESCs_Human1.15382534
60ELK1_19687146_ChIP-ChIP_HELA_Human1.13511061
61PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11878423
62PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11760343
63EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.10973276
64GATA3_26560356_Chip-Seq_TH2_Human1.10679517
65ER_23166858_ChIP-Seq_MCF-7_Human1.07224772
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06251076
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03460387
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03446318
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03387972
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02180505
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02113947
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.01264015
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01113717
74FOXH1_21741376_ChIP-Seq_EPCs_Human1.00243285
75NOTCH1_21737748_ChIP-Seq_TLL_Human0.99859688
76FUS_26573619_Chip-Seq_HEK293_Human0.99623692
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97422397
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97264157
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96121836
80YY1_22570637_ChIP-Seq_MALME-3M_Human0.94771783
81STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94367236
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94333541
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.94333541
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94132089
85BCL6_27268052_Chip-Seq_Bcells_Human0.93440167
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92820921
87RNF2_27304074_Chip-Seq_NSC_Mouse0.92468567
88HTT_18923047_ChIP-ChIP_STHdh_Human0.91753649
89TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91287080
90MYC_18358816_ChIP-ChIP_MESCs_Mouse0.91003791
91NANOG_19829295_ChIP-Seq_ESCs_Human0.90555369
92SOX2_19829295_ChIP-Seq_ESCs_Human0.90555369
93ERG_20517297_ChIP-Seq_VCAP_Human0.89310223
94AR_21572438_ChIP-Seq_LNCaP_Human0.88445137
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88338381
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88085482
97JARID2_20075857_ChIP-Seq_MESCs_Mouse0.87979015
98EZH2_27294783_Chip-Seq_ESCs_Mouse0.87853740
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84520997
100RUNX_20019798_ChIP-Seq_JUKART_Human0.83433296

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.34813100
2MP0006292_abnormal_olfactory_placode4.15434090
3MP0004145_abnormal_muscle_electrophysio3.59421849
4MP0002638_abnormal_pupillary_reflex3.50569895
5MP0009379_abnormal_foot_pigmentation3.44780337
6MP0003646_muscle_fatigue3.41584980
7MP0004147_increased_porphyrin_level2.74888497
8MP0002138_abnormal_hepatobiliary_system2.24363471
9MP0000372_irregular_coat_pigmentation2.16951105
10MP0005645_abnormal_hypothalamus_physiol1.84837068
11MP0009333_abnormal_splenocyte_physiolog1.84361465
12MP0008877_abnormal_DNA_methylation1.81423470
13MP0009785_altered_susceptibility_to1.79303577
14MP0005083_abnormal_biliary_tract1.79034583
15MP0003787_abnormal_imprinting1.74361764
16MP0001835_abnormal_antigen_presentation1.72226339
17MP0002837_dystrophic_cardiac_calcinosis1.67990300
18MP0008789_abnormal_olfactory_epithelium1.67325960
19MP0001968_abnormal_touch/_nociception1.66416872
20MP0001905_abnormal_dopamine_level1.66362646
21MP0006072_abnormal_retinal_apoptosis1.66261285
22MP0002102_abnormal_ear_morphology1.64567566
23MP0002095_abnormal_skin_pigmentation1.60868951
24MP0002736_abnormal_nociception_after1.55763864
25MP0003763_abnormal_thymus_physiology1.55173691
26MP0002277_abnormal_respiratory_mucosa1.52493139
27MP0005551_abnormal_eye_electrophysiolog1.51212717
28MP0002876_abnormal_thyroid_physiology1.43681308
29MP0004142_abnormal_muscle_tone1.42123182
30MP0001800_abnormal_humoral_immune1.39560391
31MP0000747_muscle_weakness1.39029233
32MP0005084_abnormal_gallbladder_morpholo1.38043737
33MP0003786_premature_aging1.36766495
34MP0001919_abnormal_reproductive_system1.34453106
35MP0008872_abnormal_physiological_respon1.34143696
36MP0002089_abnormal_postnatal_growth/wei1.33584934
37MP0000685_abnormal_immune_system1.29711143
38MP0008995_early_reproductive_senescence1.29503503
39MP0005000_abnormal_immune_tolerance1.28891404
40MP0005389_reproductive_system_phenotype1.27930512
41MP0003878_abnormal_ear_physiology1.26650888
42MP0005377_hearing/vestibular/ear_phenot1.26650888
43MP0005387_immune_system_phenotype1.26598323
44MP0001790_abnormal_immune_system1.26598323
45MP0004036_abnormal_muscle_relaxation1.25302833
46MP0002723_abnormal_immune_serum1.25255526
47MP0002148_abnormal_hypersensitivity_rea1.24853846
48MP0003880_abnormal_central_pattern1.22827495
49MP0000749_muscle_degeneration1.21658866
50MP0004885_abnormal_endolymph1.21436524
51MP0002420_abnormal_adaptive_immunity1.18684170
52MP0001485_abnormal_pinna_reflex1.14692372
53MP0001819_abnormal_immune_cell1.13220988
54MP0002160_abnormal_reproductive_system1.12494506
55MP0002938_white_spotting1.08746236
56MP0001661_extended_life_span1.07871850
57MP0005025_abnormal_response_to1.05148456
58MP0002163_abnormal_gland_morphology1.04458160
59MP0003959_abnormal_lean_body1.03962221
60MP0001873_stomach_inflammation1.02754507
61MP0003866_abnormal_defecation1.01262336
62MP0005423_abnormal_somatic_nervous0.99611256
63MP0009745_abnormal_behavioral_response0.97692037
64MP0002106_abnormal_muscle_physiology0.97165967
65MP0005620_abnormal_muscle_contractility0.96523520
66MP0006276_abnormal_autonomic_nervous0.94153623
67MP0000631_abnormal_neuroendocrine_gland0.93784091
68MP0002272_abnormal_nervous_system0.93560458
69MP0005499_abnormal_olfactory_system0.93427250
70MP0005394_taste/olfaction_phenotype0.93427250
71MP0002733_abnormal_thermal_nociception0.92951068
72MP0004130_abnormal_muscle_cell0.90954817
73MP0008875_abnormal_xenobiotic_pharmacok0.90642129
74MP0000716_abnormal_immune_system0.90412644
75MP0002269_muscular_atrophy0.89033607
76MP0002108_abnormal_muscle_morphology0.88343522
77MP0000049_abnormal_middle_ear0.87303870
78MP0005410_abnormal_fertilization0.86567187
79MP0005646_abnormal_pituitary_gland0.84723237
80MP0002398_abnormal_bone_marrow0.84071627
81MP0005253_abnormal_eye_physiology0.83852288
82MP0005636_abnormal_mineral_homeostasis0.83188488
83MP0000759_abnormal_skeletal_muscle0.82819920
84MP0001293_anophthalmia0.82653567
85MP0002452_abnormal_antigen_presenting0.81757818
86MP0004742_abnormal_vestibular_system0.81712451
87MP0001970_abnormal_pain_threshold0.78877951
88MP0001486_abnormal_startle_reflex0.77339696
89MP0005379_endocrine/exocrine_gland_phen0.75318771
90MP0000703_abnormal_thymus_morphology0.73564412
91MP0005369_muscle_phenotype0.73311722
92MP0001119_abnormal_female_reproductive0.72136961
93MP0003806_abnormal_nucleotide_metabolis0.71960216
94MP0001765_abnormal_ion_homeostasis0.71676457
95MP0003252_abnormal_bile_duct0.70536185
96MP0002006_tumorigenesis0.70448616
97MP0002653_abnormal_ependyma_morphology0.70279449
98MP0002166_altered_tumor_susceptibility0.70135743
99MP0001986_abnormal_taste_sensitivity0.68967175
100MP0005195_abnormal_posterior_eye0.66828096

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)4.75020462
2Aplastic anemia (HP:0001915)4.36013074
3Acute necrotizing encephalopathy (HP:0006965)4.25081750
4Congenital stationary night blindness (HP:0007642)4.06705991
5Mitochondrial inheritance (HP:0001427)3.99578714
6Abnormal mitochondria in muscle tissue (HP:0008316)3.84965873
7Increased CSF lactate (HP:0002490)3.51713114
8Acute encephalopathy (HP:0006846)3.51632258
9Progressive macrocephaly (HP:0004481)3.46114010
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.39718401
11Increased hepatocellular lipid droplets (HP:0006565)3.31449979
12IgG deficiency (HP:0004315)3.27473888
13Abnormal rod and cone electroretinograms (HP:0008323)3.18438293
14Increased intramyocellular lipid droplets (HP:0012240)3.09749351
15Hepatocellular necrosis (HP:0001404)3.08155738
16Absent phalangeal crease (HP:0006109)3.03487534
17Lipid accumulation in hepatocytes (HP:0006561)3.02644776
18Elevated erythrocyte sedimentation rate (HP:0003565)2.90295780
19Distal arthrogryposis (HP:0005684)2.88285556
203-Methylglutaconic aciduria (HP:0003535)2.87589055
21Abnormality of midbrain morphology (HP:0002418)2.85986367
22Molar tooth sign on MRI (HP:0002419)2.85986367
23Renal Fanconi syndrome (HP:0001994)2.85292524
24T lymphocytopenia (HP:0005403)2.83948055
25Hypoproteinemia (HP:0003075)2.83733385
26Cerebral edema (HP:0002181)2.83275526
27Periorbital edema (HP:0100539)2.80836864
28Hepatic necrosis (HP:0002605)2.76168474
29Reticulocytopenia (HP:0001896)2.74818610
30Nemaline bodies (HP:0003798)2.74809281
31Abnormality of cells of the erythroid lineage (HP:0012130)2.73675470
32Facial edema (HP:0000282)2.65775446
33Abnormality of T cell number (HP:0011839)2.56867605
34Increased muscle lipid content (HP:0009058)2.56210087
35Exertional dyspnea (HP:0002875)2.49447608
36Abnormality of the prostate (HP:0008775)2.47886933
37Abnormal finger flexion creases (HP:0006143)2.47781812
38Abnormal number of erythroid precursors (HP:0012131)2.40098546
39Mask-like facies (HP:0000298)2.37925160
40Pancreatic fibrosis (HP:0100732)2.36677000
41Round ear (HP:0100830)2.36401006
42Severe combined immunodeficiency (HP:0004430)2.35608688
43Optic disc pallor (HP:0000543)2.33697475
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.32132499
45Macrocytic anemia (HP:0001972)2.31967717
46Increased serum lactate (HP:0002151)2.29603472
47Myotonia (HP:0002486)2.28330920
48Pancreatic cysts (HP:0001737)2.26747891
49Ulnar deviation of the wrist (HP:0003049)2.22800793
50Exercise intolerance (HP:0003546)2.20955197
51Increased IgM level (HP:0003496)2.20474580
52Autoimmune hemolytic anemia (HP:0001890)2.20333586
53Muscle fiber inclusion bodies (HP:0100299)2.19543079
54Type 2 muscle fiber atrophy (HP:0003554)2.18989580
55Abolished electroretinogram (ERG) (HP:0000550)2.18498679
56Calcaneovalgus deformity (HP:0001848)2.18265095
57Pendular nystagmus (HP:0012043)2.17854827
58Reduced antithrombin III activity (HP:0001976)2.15664357
59Lactic acidosis (HP:0003128)2.13971460
60Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.12014110
61True hermaphroditism (HP:0010459)2.11923159
62Pancytopenia (HP:0001876)2.10716934
63Deformed tarsal bones (HP:0008119)2.09780375
64Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05261835
65Lethargy (HP:0001254)2.04015421
66Abnormal drinking behavior (HP:0030082)2.03152380
67Polydipsia (HP:0001959)2.03152380
68Abnormality of T cells (HP:0002843)2.03053142
69Oligomenorrhea (HP:0000876)2.01937472
70Abnormality of B cell number (HP:0010975)2.01754054
71B lymphocytopenia (HP:0010976)1.99894639
72Exercise-induced myalgia (HP:0003738)1.99848804
73Type II lissencephaly (HP:0007260)1.98204088
74Pallor (HP:0000980)1.96472421
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93342256
76Thyroiditis (HP:0100646)1.91273950
77Hypoplasia of the fovea (HP:0007750)1.90158243
78Aplasia/Hypoplasia of the fovea (HP:0008060)1.90158243
79Muscle fiber atrophy (HP:0100295)1.87934062
80Decreased circulating renin level (HP:0003351)1.85682947
81Constricted visual fields (HP:0001133)1.83301551
82Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83092600
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83092600
84Attenuation of retinal blood vessels (HP:0007843)1.82780049
85Stomatitis (HP:0010280)1.82657606
86Pigmentary retinal degeneration (HP:0001146)1.82481299
87Abnormality of renal resorption (HP:0011038)1.80341114
88Aplasia/Hypoplasia of the spleen (HP:0010451)1.79686938
89Hypoalbuminemia (HP:0003073)1.79350697
90Abnormal albumin level (HP:0012116)1.79350697
91Abnormality of the fovea (HP:0000493)1.79342116
92Decreased central vision (HP:0007663)1.78960773
93Asplenia (HP:0001746)1.77926818
94IgM deficiency (HP:0002850)1.77448896
95Nephronophthisis (HP:0000090)1.77005073
96Respiratory failure (HP:0002878)1.76609338
97Symphalangism affecting the phalanges of the hand (HP:0009773)1.75630160
98Severe visual impairment (HP:0001141)1.74036113
99Polyuria (HP:0000103)1.73639505
100Hyperglycinemia (HP:0002154)1.73526184

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.69565112
2TESK24.05998860
3KDR3.95676645
4BCKDK3.17741194
5MAP4K12.86183305
6VRK22.65685955
7TIE12.39351180
8WNK42.36158338
9GRK12.34129466
10MAP3K122.26527202
11ADRBK22.14974021
12TLK12.08118464
13OBSCN2.05477075
14ZAK2.01926720
15PHKG11.81684285
16PHKG21.81684285
17MAP4K21.78360944
18MAPK131.71650583
19NUAK11.67653241
20ITK1.66754321
21TYRO31.62867248
22PIK3CA1.62437929
23DYRK21.53410442
24VRK11.47457278
25MAP3K111.44387747
26LIMK11.42677274
27MST41.29600659
28CDK191.26004919
29MUSK1.19538368
30SYK1.17984911
31JAK31.15220329
32FES1.15137074
33TAOK31.10896469
34TEC1.09871684
35MAPKAPK31.08986015
36PRKCQ1.07785044
37SCYL21.06310613
38INSRR0.98410753
39CAMKK20.97627312
40OXSR10.95307058
41PRKCI0.95128509
42STK160.91106133
43PIK3CG0.88848932
44BTK0.87034723
45DAPK30.83443136
46TESK10.81989392
47CSK0.81692052
48BMPR20.80724126
49LCK0.80715069
50BMPR1B0.80436463
51WNK10.78799461
52AURKA0.78322593
53FRK0.78240243
54RPS6KA50.78060583
55PINK10.76993904
56DAPK20.76019274
57TAOK20.72004904
58DAPK10.71795246
59GRK60.71373847
60PRKCG0.70070681
61GRK70.69461182
62WNK30.69395136
63STK390.68677072
64MYLK0.67935773
65CHEK20.64787404
66CAMK10.62156184
67PIM20.61844088
68IKBKB0.61451126
69RIPK10.58185805
70PLK40.57080326
71PIM10.53618778
72BUB10.52464036
73PRKACA0.50702612
74ADRBK10.50466298
75CAMKK10.49920317
76LYN0.47690270
77NME10.46972846
78ATR0.44208285
79PRKCA0.43336023
80LRRK20.42276060
81CSNK2A10.41964437
82CSNK1G30.41650920
83PRKCD0.41601832
84CSNK2A20.38464513
85TNK20.37239875
86PKN10.36632430
87CAMK2G0.36599231
88CSNK1A10.35339682
89KIT0.32484050
90MAP2K70.31976927
91CSNK1G10.31437554
92FYN0.30828938
93ABL20.30545027
94PASK0.30188996
95CASK0.29820824
96TAF10.29108989
97ILK0.28254229
98PRKCE0.27721282
99IGF1R0.27654238
100PRKCB0.26422912

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.74198594
2Proteasome_Homo sapiens_hsa030504.11730914
3Oxidative phosphorylation_Homo sapiens_hsa001904.06529706
4Primary immunodeficiency_Homo sapiens_hsa053403.70118803
5Parkinsons disease_Homo sapiens_hsa050123.45831595
6Graft-versus-host disease_Homo sapiens_hsa053322.45110926
7Cardiac muscle contraction_Homo sapiens_hsa042602.44592960
8Alzheimers disease_Homo sapiens_hsa050102.38284619
9Autoimmune thyroid disease_Homo sapiens_hsa053202.35908786
10Huntingtons disease_Homo sapiens_hsa050162.25946837
11Allograft rejection_Homo sapiens_hsa053302.20576983
12RNA polymerase_Homo sapiens_hsa030202.16392500
13Antigen processing and presentation_Homo sapiens_hsa046122.13810139
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.13730123
15Asthma_Homo sapiens_hsa053101.97280048
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89987029
17Protein export_Homo sapiens_hsa030601.79588398
18Phototransduction_Homo sapiens_hsa047441.76057175
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72045171
20Nitrogen metabolism_Homo sapiens_hsa009101.63539363
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63240730
22Type I diabetes mellitus_Homo sapiens_hsa049401.57011961
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.49719620
24Hematopoietic cell lineage_Homo sapiens_hsa046401.49619713
25T cell receptor signaling pathway_Homo sapiens_hsa046601.42006740
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40871517
27RNA degradation_Homo sapiens_hsa030181.32202697
28Linoleic acid metabolism_Homo sapiens_hsa005911.15093495
29Regulation of autophagy_Homo sapiens_hsa041401.12542305
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12246187
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11457449
32Pyrimidine metabolism_Homo sapiens_hsa002401.10279236
33Homologous recombination_Homo sapiens_hsa034401.09710636
34Sulfur relay system_Homo sapiens_hsa041221.02405657
35Rheumatoid arthritis_Homo sapiens_hsa053231.02065687
36Olfactory transduction_Homo sapiens_hsa047401.01433936
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00775138
38Peroxisome_Homo sapiens_hsa041461.00202394
39Fanconi anemia pathway_Homo sapiens_hsa034600.96775560
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86708026
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85247785
42Systemic lupus erythematosus_Homo sapiens_hsa053220.84221857
43Caffeine metabolism_Homo sapiens_hsa002320.81749398
44Purine metabolism_Homo sapiens_hsa002300.81606098
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79403181
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78858818
47Chemical carcinogenesis_Homo sapiens_hsa052040.76543982
48Butanoate metabolism_Homo sapiens_hsa006500.75111206
49One carbon pool by folate_Homo sapiens_hsa006700.73816395
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.73076003
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69900975
52Basal transcription factors_Homo sapiens_hsa030220.69622118
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.69260182
54Viral myocarditis_Homo sapiens_hsa054160.69005635
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68491034
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67373099
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65426168
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.64865740
59Retinol metabolism_Homo sapiens_hsa008300.63145826
60Tyrosine metabolism_Homo sapiens_hsa003500.61209955
61Measles_Homo sapiens_hsa051620.60993646
62Nucleotide excision repair_Homo sapiens_hsa034200.57293302
63Spliceosome_Homo sapiens_hsa030400.56531713
64Nicotine addiction_Homo sapiens_hsa050330.55209824
65Mismatch repair_Homo sapiens_hsa034300.54724319
66Morphine addiction_Homo sapiens_hsa050320.52981095
67Tight junction_Homo sapiens_hsa045300.52507163
68DNA replication_Homo sapiens_hsa030300.51393408
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49981434
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48121778
71Metabolic pathways_Homo sapiens_hsa011000.47251809
72Base excision repair_Homo sapiens_hsa034100.40637440
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39714683
74Malaria_Homo sapiens_hsa051440.38050580
75Fat digestion and absorption_Homo sapiens_hsa049750.37301184
76Propanoate metabolism_Homo sapiens_hsa006400.36782242
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33048497
78Calcium signaling pathway_Homo sapiens_hsa040200.30370321
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28841550
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28642759
81Collecting duct acid secretion_Homo sapiens_hsa049660.28480713
82Arachidonic acid metabolism_Homo sapiens_hsa005900.28253832
83Ether lipid metabolism_Homo sapiens_hsa005650.28110641
84RNA transport_Homo sapiens_hsa030130.27640223
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.27602195
86Oxytocin signaling pathway_Homo sapiens_hsa049210.27530191
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27012089
88Taste transduction_Homo sapiens_hsa047420.26732313
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26708258
90Hedgehog signaling pathway_Homo sapiens_hsa043400.26220716
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25291778
92Tryptophan metabolism_Homo sapiens_hsa003800.24121329
93GABAergic synapse_Homo sapiens_hsa047270.23211605
94Folate biosynthesis_Homo sapiens_hsa007900.22529462
95Epstein-Barr virus infection_Homo sapiens_hsa051690.20662124
96Glutathione metabolism_Homo sapiens_hsa004800.18316133
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18244342
98Circadian entrainment_Homo sapiens_hsa047130.14864386
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.14632757
100Shigellosis_Homo sapiens_hsa051310.14094904

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