ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	7.05273357
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.08883390
3	platelet dense granule organization (GO:0060155)	6.01994967
4	regulation of cilium movement (GO:0003352)	6.00737388
5	synapsis (GO:0007129)	5.89757559
6	epithelial cilium movement (GO:0003351)	5.09359459
7	DNA methylation involved in gamete generation (GO:0043046)	5.08365551
8	male meiosis I (GO:0007141)	5.04772849
9	centriole replication (GO:0007099)	4.67674828
10	cellular ketone body metabolic process (GO:0046950)	4.60528165
11	protein K11-linked deubiquitination (GO:0035871)	4.52457498
12	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.42434628
13	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.42434628
14	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.42434628
15	endosome to pigment granule transport (GO:0043485)	4.41488517
16	endosome to melanosome transport (GO:0035646)	4.41488517
17	cilium or flagellum-dependent cell motility (GO:0001539)	4.20535217
18	chromosome organization involved in meiosis (GO:0070192)	4.17235504
19	meiosis I (GO:0007127)	4.16543200
20	neural tube formation (GO:0001841)	4.16442400
21	male meiosis (GO:0007140)	4.16392432
22	retinal cone cell development (GO:0046549)	4.15719504
23	establishment of protein localization to Golgi (GO:0072600)	4.09312092
24	ketone body metabolic process (GO:1902224)	4.01578661
25	cilium morphogenesis (GO:0060271)	3.96604832
26	cilium movement (GO:0003341)	3.92236961
27	regulation of meiosis I (GO:0060631)	3.90736572
28	attachment of spindle microtubules to kinetochore (GO:0008608)	3.84332285
29	regulation of microtubule-based movement (GO:0060632)	3.80869341
30	C4-dicarboxylate transport (GO:0015740)	3.78788737
31	neuron fate determination (GO:0048664)	3.77959053
32	acrosome reaction (GO:0007340)	3.76234199
33	protein targeting to Golgi (GO:0000042)	3.74464327
34	protein polyglutamylation (GO:0018095)	3.73632829
35	sperm motility (GO:0030317)	3.63269011
36	reciprocal DNA recombination (GO:0035825)	3.61708622
37	reciprocal meiotic recombination (GO:0007131)	3.61708622
38	microtubule depolymerization (GO:0007019)	3.59383856
39	microtubule polymerization or depolymerization (GO:0031109)	3.56454230
40	female gamete generation (GO:0007292)	3.56270398
41	somite development (GO:0061053)	3.55115727
42	photoreceptor cell maintenance (GO:0045494)	3.47639919
43	meiotic nuclear division (GO:0007126)	3.46657224
44	detection of light stimulus involved in sensory perception (GO:0050962)	3.40703207
45	detection of light stimulus involved in visual perception (GO:0050908)	3.40703207
46	intraciliary transport (GO:0042073)	3.38260134
47	behavioral response to nicotine (GO:0035095)	3.35279316
48	response to pheromone (GO:0019236)	3.34470660
49	meiotic cell cycle process (GO:1903046)	3.34391812
50	fucose catabolic process (GO:0019317)	3.34219589
51	L-fucose metabolic process (GO:0042354)	3.34219589
52	L-fucose catabolic process (GO:0042355)	3.34219589
53	meiotic cell cycle (GO:0051321)	3.33601393
54	spermatid development (GO:0007286)	3.33126609
55	centriole assembly (GO:0098534)	3.30855542
56	response to nitrosative stress (GO:0051409)	3.29085016
57	multicellular organism reproduction (GO:0032504)	3.28673937
58	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.27863168
59	somite rostral/caudal axis specification (GO:0032525)	3.26506538
60	cilium assembly (GO:0042384)	3.25653009
61	cilium organization (GO:0044782)	3.24080591
62	gene silencing by RNA (GO:0031047)	3.17304759
63	axoneme assembly (GO:0035082)	3.16796958
64	peptidyl-cysteine modification (GO:0018198)	3.14128165
65	melanosome transport (GO:0032402)	3.13946308
66	smoothened signaling pathway (GO:0007224)	3.11843724
67	nonmotile primary cilium assembly (GO:0035058)	3.10141922
68	aldehyde catabolic process (GO:0046185)	3.07533510
69	pigment granule transport (GO:0051904)	3.07165900
70	synaptonemal complex assembly (GO:0007130)	2.99136896
71	establishment of melanosome localization (GO:0032401)	2.98756747
72	fucose metabolic process (GO:0006004)	2.98697297
73	establishment of pigment granule localization (GO:0051905)	2.92931555
74	presynaptic membrane assembly (GO:0097105)	2.87360291
75	meiotic chromosome segregation (GO:0045132)	2.85795054
76	photoreceptor cell development (GO:0042461)	2.83884789
77	secretory granule organization (GO:0033363)	2.83508062
78	microtubule anchoring (GO:0034453)	2.82631258
79	fusion of sperm to egg plasma membrane (GO:0007342)	2.81736748
80	glycine transport (GO:0015816)	2.81579021
81	synaptonemal complex organization (GO:0070193)	2.77503792
82	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.76484374
83	regulation of DNA methylation (GO:0044030)	2.76299846
84	preassembly of GPI anchor in ER membrane (GO:0016254)	2.73900593
85	genitalia morphogenesis (GO:0035112)	2.73362476
86	DNA synthesis involved in DNA repair (GO:0000731)	2.72676811
87	protein localization to Golgi apparatus (GO:0034067)	2.70477785
88	eye photoreceptor cell development (GO:0042462)	2.70305438
89	resolution of meiotic recombination intermediates (GO:0000712)	2.69518684
90	oogenesis (GO:0048477)	2.68585570
91	spermatogenesis (GO:0007283)	2.68483478
92	male gamete generation (GO:0048232)	2.68071948
93	anterograde synaptic vesicle transport (GO:0048490)	2.66906011
94	microtubule severing (GO:0051013)	2.66180531
95	mitotic sister chromatid cohesion (GO:0007064)	2.65520540
96	gamete generation (GO:0007276)	2.65513759
97	axonemal dynein complex assembly (GO:0070286)	2.64741985
98	brain morphogenesis (GO:0048854)	2.64672491
99	motile cilium assembly (GO:0044458)	2.61965264
100	presynaptic membrane organization (GO:0097090)	2.61699286

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.90695748
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.44897241
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.18919569
4	VDR_22108803_ChIP-Seq_LS180_Human	2.89654336
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.86098240
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.73394070
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.70187622
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.66974282
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.64170770
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.51659580
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.43948679
12	P300_19829295_ChIP-Seq_ESCs_Human	2.32758454
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.28297990
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.12807683
15	CBP_20019798_ChIP-Seq_JUKART_Human	2.11574576
16	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.11574576
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.10827609
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.04056260
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98025787
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.96974837
21	FUS_26573619_Chip-Seq_HEK293_Human	1.94483662
22	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.93850765
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.90969503
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.87295939
25	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.87128034
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.84155410
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.80537513
28	STAT3_23295773_ChIP-Seq_U87_Human	1.76276766
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.75732233
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.75092813
31	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.73621479
32	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.69496567
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.68068011
34	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.67078450
35	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.67078450
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.65029447
37	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.62272268
38	EWS_26573619_Chip-Seq_HEK293_Human	1.62195603
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.60475024
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.60311776
41	AR_25329375_ChIP-Seq_VCAP_Human	1.58726089
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56271426
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.55002831
44	TCF4_23295773_ChIP-Seq_U87_Human	1.54147097
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.53894414
46	RUNX2_22187159_ChIP-Seq_PCA_Human	1.51753394
47	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.49950794
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.47861240
49	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.47067052
50	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.41152253
51	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.39500081
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.39233793
53	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.38371353
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35484845
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35484845
56	TP53_16413492_ChIP-PET_HCT116_Human	1.34927053
57	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.33083594
58	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.32444189
59	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.32113772
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31059353
61	BCAT_22108803_ChIP-Seq_LS180_Human	1.30602653
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30160786
63	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.29129642
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28878821
65	TCF4_22108803_ChIP-Seq_LS180_Human	1.25842883
66	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.24279298
67	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.23096341
68	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20637192
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.20371023
70	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17419829
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.15660545
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14083797
73	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14008099
74	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13291779
75	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11415956
76	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.11009128
77	TBL1_22424771_ChIP-Seq_293T_Human	1.10875791
78	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.10532656
79	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.09266442
80	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.08588361
81	NFYB_21822215_ChIP-Seq_K562_Human	1.07772949
82	RXR_22108803_ChIP-Seq_LS180_Human	1.06716355
83	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.06272242
84	MYC_18940864_ChIP-ChIP_HL60_Human	1.06003562
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03718796
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02809004
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01608556
88	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.01550334
89	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01458773
90	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.00164975
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99435377
92	ETV1_20927104_ChIP-Seq_GIST48_Human	0.98718568
93	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.98377561
94	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.98049498
95	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97139881
96	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.95530304
97	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.95439327
98	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.95144535
99	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.94284599
100	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.94075134

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	5.00310097
2	MP0006292_abnormal_olfactory_placode	3.86289594
3	MP0003718_maternal_effect	3.06594422
4	MP0008789_abnormal_olfactory_epithelium	2.66756016
5	MP0005410_abnormal_fertilization	2.45533421
6	MP0002928_abnormal_bile_duct	2.21915425
7	MP0001984_abnormal_olfaction	2.19850624
8	MP0005551_abnormal_eye_electrophysiolog	2.19348888
9	MP0002254_reproductive_system_inflammat	2.17465742
10	MP0002837_dystrophic_cardiac_calcinosis	2.17134607
11	MP0002822_catalepsy	2.15207239
12	MP0000427_abnormal_hair_cycle	2.07045878
13	MP0003122_maternal_imprinting	2.01517802
14	MP0005394_taste/olfaction_phenotype	1.99737776
15	MP0005499_abnormal_olfactory_system	1.99737776
16	MP0003787_abnormal_imprinting	1.95644773
17	MP0003880_abnormal_central_pattern	1.94209417
18	MP0010386_abnormal_urinary_bladder	1.93743856
19	MP0002163_abnormal_gland_morphology	1.86422846
20	MP0003195_calcinosis	1.85738167
21	MP0002139_abnormal_hepatobiliary_system	1.81756847
22	MP0001929_abnormal_gametogenesis	1.80633032
23	MP0003698_abnormal_male_reproductive	1.62578968
24	MP0005395_other_phenotype	1.62118713
25	MP0003252_abnormal_bile_duct	1.61558087
26	MP0001486_abnormal_startle_reflex	1.60547940
27	MP0005310_abnormal_salivary_gland	1.60356951
28	MP0003121_genomic_imprinting	1.58649718
29	MP0002210_abnormal_sex_determination	1.55400482
30	MP0002095_abnormal_skin_pigmentation	1.54798717
31	MP0005253_abnormal_eye_physiology	1.47769808
32	MP0001501_abnormal_sleep_pattern	1.45466238
33	MP0004742_abnormal_vestibular_system	1.43493774
34	MP0005174_abnormal_tail_pigmentation	1.42823819
35	MP0000372_irregular_coat_pigmentation	1.40732456
36	MP0002234_abnormal_pharynx_morphology	1.40171765
37	MP0000778_abnormal_nervous_system	1.38127923
38	MP0003646_muscle_fatigue	1.36059885
39	MP0005379_endocrine/exocrine_gland_phen	1.34922858
40	MP0010030_abnormal_orbit_morphology	1.31253451
41	MP0003950_abnormal_plasma_membrane	1.30732079
42	MP0001324_abnormal_eye_pigmentation	1.26585551
43	MP0008775_abnormal_heart_ventricle	1.26583297
44	MP0000653_abnormal_sex_gland	1.23667386
45	MP0000569_abnormal_digit_pigmentation	1.23052022
46	MP0003136_yellow_coat_color	1.21598707
47	MP0002272_abnormal_nervous_system	1.20470908
48	MP0000383_abnormal_hair_follicle	1.19229692
49	MP0002160_abnormal_reproductive_system	1.18325353
50	MP0002138_abnormal_hepatobiliary_system	1.18044541
51	MP0002102_abnormal_ear_morphology	1.16492476
52	MP0008995_early_reproductive_senescence	1.16347819
53	MP0006276_abnormal_autonomic_nervous	1.11727528
54	MP0009745_abnormal_behavioral_response	1.11333882
55	MP0004043_abnormal_pH_regulation	1.10905038
56	MP0002161_abnormal_fertility/fecundity	1.10892036
57	MP0004134_abnormal_chest_morphology	1.10488441
58	MP0002557_abnormal_social/conspecific_i	1.08295478
59	MP0000631_abnormal_neuroendocrine_gland	1.08186350
60	MP0000647_abnormal_sebaceous_gland	1.07785655
61	MP0005085_abnormal_gallbladder_physiolo	1.06835584
62	MP0000538_abnormal_urinary_bladder	1.04955206
63	MP0004133_heterotaxia	1.04879470
64	MP0010678_abnormal_skin_adnexa	1.04506496
65	MP0002653_abnormal_ependyma_morphology	1.02277447
66	MP0002751_abnormal_autonomic_nervous	1.01236170
67	MP0001145_abnormal_male_reproductive	1.01037303
68	MP0002734_abnormal_mechanical_nocicepti	1.01031520
69	MP0005646_abnormal_pituitary_gland	0.97699697
70	MP0001963_abnormal_hearing_physiology	0.95906421
71	MP0006072_abnormal_retinal_apoptosis	0.95750179
72	MP0001485_abnormal_pinna_reflex	0.94332680
73	MP0000015_abnormal_ear_pigmentation	0.93750840
74	MP0009046_muscle_twitch	0.92948224
75	MP0003699_abnormal_female_reproductive	0.91065321
76	MP0002638_abnormal_pupillary_reflex	0.90714296
77	MP0001293_anophthalmia	0.89493346
78	MP0002752_abnormal_somatic_nervous	0.89413134
79	MP0002233_abnormal_nose_morphology	0.89071133
80	MP0009250_abnormal_appendicular_skeleto	0.88263413
81	MP0005195_abnormal_posterior_eye	0.88094398
82	MP0000026_abnormal_inner_ear	0.86043957
83	MP0008058_abnormal_DNA_repair	0.85799387
84	MP0001119_abnormal_female_reproductive	0.84496190
85	MP0002063_abnormal_learning/memory/cond	0.83301444
86	MP0002572_abnormal_emotion/affect_behav	0.81896062
87	MP0005377_hearing/vestibular/ear_phenot	0.81474395
88	MP0003878_abnormal_ear_physiology	0.81474395
89	MP0001764_abnormal_homeostasis	0.81358989
90	MP0002184_abnormal_innervation	0.79816097
91	MP0002067_abnormal_sensory_capabilities	0.79679085
92	MP0005391_vision/eye_phenotype	0.79313096
93	MP0002938_white_spotting	0.78629534
94	MP0001299_abnormal_eye_distance/	0.78581999
95	MP0004215_abnormal_myocardial_fiber	0.77944990
96	MP0002090_abnormal_vision	0.77644121
97	MP0010307_abnormal_tumor_latency	0.77548024
98	MP0005386_behavior/neurological_phenoty	0.76852403
99	MP0004924_abnormal_behavior	0.76852403
100	MP0004142_abnormal_muscle_tone	0.76290466

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Volvulus (HP:0002580)	5.10651293
2	Abnormality of midbrain morphology (HP:0002418)	4.57701829
3	Molar tooth sign on MRI (HP:0002419)	4.57701829
4	Chronic hepatic failure (HP:0100626)	4.35315128
5	Pancreatic fibrosis (HP:0100732)	3.99264826
6	Pancreatic cysts (HP:0001737)	3.87133897
7	True hermaphroditism (HP:0010459)	3.80178035
8	Medial flaring of the eyebrow (HP:0010747)	3.64973637
9	Nephronophthisis (HP:0000090)	3.45756012
10	Hepatoblastoma (HP:0002884)	3.36780667
11	Hyperventilation (HP:0002883)	3.31623921
12	Abnormality of macular pigmentation (HP:0008002)	3.26975104
13	3-Methylglutaconic aciduria (HP:0003535)	3.23938323
14	Cystic liver disease (HP:0006706)	3.20345186
15	Oligodactyly (hands) (HP:0001180)	3.20184065
16	Renal cortical cysts (HP:0000803)	3.16574438
17	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.01804991
18	Tubulointerstitial nephritis (HP:0001970)	3.00248122
19	Median cleft lip (HP:0000161)	2.97420113
20	Congenital primary aphakia (HP:0007707)	2.94885879
21	Intestinal atresia (HP:0011100)	2.94879822
22	Gait imbalance (HP:0002141)	2.91650244
23	Absent/shortened dynein arms (HP:0200106)	2.89141547
24	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.89141547
25	Abnormality of the renal medulla (HP:0100957)	2.87854765
26	Congenital stationary night blindness (HP:0007642)	2.86029663
27	Abnormality of the renal cortex (HP:0011035)	2.81825667
28	Bifid tongue (HP:0010297)	2.76367310
29	Proximal tubulopathy (HP:0000114)	2.72678973
30	Congenital hepatic fibrosis (HP:0002612)	2.63723889
31	Pancreatic islet-cell hyperplasia (HP:0004510)	2.62077206
32	Supernumerary spleens (HP:0009799)	2.61571851
33	Methylmalonic acidemia (HP:0002912)	2.56081374
34	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.55182989
35	Severe visual impairment (HP:0001141)	2.54697315
36	Anencephaly (HP:0002323)	2.52611458
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.52243633
38	Genital tract atresia (HP:0001827)	2.47412040
39	Poor coordination (HP:0002370)	2.46854499
40	Hypoplasia of the fovea (HP:0007750)	2.42132642
41	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.42132642
42	Nephrogenic diabetes insipidus (HP:0009806)	2.40766541
43	Facial hemangioma (HP:0000329)	2.40233323
44	Decreased central vision (HP:0007663)	2.37736709
45	Vaginal atresia (HP:0000148)	2.36832318
46	Large for gestational age (HP:0001520)	2.32909811
47	Postaxial hand polydactyly (HP:0001162)	2.30730668
48	Intrahepatic cholestasis (HP:0001406)	2.29817302
49	Preaxial hand polydactyly (HP:0001177)	2.29074876
50	Abnormality of the labia minora (HP:0012880)	2.26563992
51	Type II lissencephaly (HP:0007260)	2.25370750
52	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.24779884
53	Oligodactyly (HP:0012165)	2.21100843
54	Albinism (HP:0001022)	2.19661312
55	Optic nerve hypoplasia (HP:0000609)	2.19155384
56	Generalized aminoaciduria (HP:0002909)	2.18485943
57	Tubulointerstitial abnormality (HP:0001969)	2.14905366
58	Sclerocornea (HP:0000647)	2.14726787
59	Postaxial foot polydactyly (HP:0001830)	2.14255562
60	Furrowed tongue (HP:0000221)	2.13348338
61	Septo-optic dysplasia (HP:0100842)	2.11717454
62	Attenuation of retinal blood vessels (HP:0007843)	2.10397033
63	Broad alveolar ridges (HP:0000187)	2.09949066
64	Abnormal respiratory epithelium morphology (HP:0012253)	2.06835971
65	Abnormal respiratory motile cilium morphology (HP:0005938)	2.06835971
66	Ketosis (HP:0001946)	2.06730155
67	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.01846079
68	Metaphyseal irregularity (HP:0003025)	2.01242575
69	Abnormal ciliary motility (HP:0012262)	2.01126099
70	Neoplasm of the adrenal cortex (HP:0100641)	1.99985248
71	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.96556224
72	Retinal atrophy (HP:0001105)	1.93966392
73	Nephroblastoma (Wilms tumor) (HP:0002667)	1.92832828
74	Abnormality of the pancreatic islet cells (HP:0006476)	1.91331240
75	Abnormality of endocrine pancreas physiology (HP:0012093)	1.91331240
76	Short tibia (HP:0005736)	1.90353608
77	Abnormality of the fovea (HP:0000493)	1.87783227
78	Focal motor seizures (HP:0011153)	1.87752503
79	Abnormal pancreas size (HP:0012094)	1.86657716
80	Hypoplastic ischia (HP:0003175)	1.86443210
81	Embryonal renal neoplasm (HP:0011794)	1.86417195
82	Bony spicule pigmentary retinopathy (HP:0007737)	1.85965745
83	Aplasia/Hypoplasia of the lens (HP:0008063)	1.85957265
84	Glycosuria (HP:0003076)	1.84491688
85	Abnormality of urine glucose concentration (HP:0011016)	1.84491688
86	Azoospermia (HP:0000027)	1.82119794
87	Male pseudohermaphroditism (HP:0000037)	1.81490635
88	Epidermoid cyst (HP:0200040)	1.81108477
89	Urethral obstruction (HP:0000796)	1.80311345
90	Cone-rod dystrophy (HP:0000548)	1.76634966
91	Narrow forehead (HP:0000341)	1.76552126
92	Hyperglycinemia (HP:0002154)	1.76386634
93	Multicystic kidney dysplasia (HP:0000003)	1.75504876
94	Gastrointestinal atresia (HP:0002589)	1.74891480
95	Hyperglycinuria (HP:0003108)	1.74206355
96	Hypoglycemic coma (HP:0001325)	1.73503212
97	Abnormality of serine family amino acid metabolism (HP:0010894)	1.72456145
98	Abnormality of glycine metabolism (HP:0010895)	1.72456145
99	Postural tremor (HP:0002174)	1.71963522
100	Ketoacidosis (HP:0001993)	1.71859219

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK1	6.16771743
2	FRK	4.73306746
3	TNIK	3.88830923
4	ACVR1B	3.57518706
5	PLK4	2.79714291
6	WNK3	2.28300567
7	PRKD3	2.05003208
8	NEK2	2.02633524
9	ADRBK2	1.81721568
10	MAP4K2	1.79121510
11	MAPK13	1.75812745
12	CDK19	1.69714636
13	WNK4	1.63867667
14	NEK6	1.57354601
15	CASK	1.56521107
16	STK38L	1.56061049
17	STK39	1.50945659
18	TESK1	1.39992980
19	INSRR	1.34773826
20	FGFR2	1.34548222
21	BUB1	1.32538959
22	LIMK1	1.25787127
23	MARK1	1.23007914
24	ARAF	1.22758523
25	EIF2AK3	1.15677202
26	PTK2B	1.15134966
27	BMPR1B	1.14544971
28	DYRK3	1.09972106
29	PNCK	1.07977224
30	MAP3K7	1.03923127
31	GRK1	1.03360737
32	DDR2	1.01125304
33	CAMK1G	1.00785764
34	MOS	0.99705771
35	MAPK15	0.98602051
36	CAMK4	0.97457978
37	PLK2	0.97062494
38	PKN1	0.94891080
39	BRD4	0.94246250
40	BCR	0.93238357
41	TRIM28	0.92158769
42	WNK1	0.91717302
43	CAMKK2	0.91483353
44	GRK7	0.88352633
45	PDK2	0.84941762
46	MARK2	0.84595044
47	CAMK1	0.84351641
48	MAP3K4	0.83156910
49	MAP3K9	0.82285860
50	PAK3	0.81980719
51	MAP3K13	0.81101356
52	TAOK3	0.80102472
53	PINK1	0.78925038
54	NTRK3	0.78389286
55	AKT3	0.76932757
56	PRKCG	0.74922349
57	SGK2	0.74354210
58	EPHA4	0.71476131
59	PRKCZ	0.70707850
60	PLK1	0.70435953
61	PRKCH	0.69732092
62	TGFBR2	0.67575056
63	TIE1	0.65407545
64	STK3	0.64459208
65	BRAF	0.63066144
66	OXSR1	0.56299555
67	PRKG1	0.55780063
68	CSNK1G2	0.54322247
69	CCNB1	0.54026280
70	CDK8	0.53912229
71	PRKCI	0.53155638
72	MARK3	0.52754316
73	CAMK2A	0.51853567
74	CAMK1D	0.50594098
75	KSR1	0.50456501
76	ZAK	0.49717869
77	BCKDK	0.49499115
78	PRKCE	0.49378118
79	NUAK1	0.46827868
80	MET	0.46259199
81	PRKAA2	0.45830647
82	PASK	0.45102332
83	SIK2	0.43459866
84	PLK3	0.43294669
85	CDK3	0.42079878
86	UHMK1	0.41492187
87	MKNK2	0.41409453
88	NTRK2	0.41015749
89	PRKACA	0.40849694
90	MAPK7	0.39819207
91	PRKACB	0.39801721
92	ATM	0.39598017
93	MKNK1	0.38679401
94	RPS6KB1	0.38605539
95	SGK1	0.37296038
96	TYK2	0.36007966
97	MUSK	0.35303024
98	PRKD2	0.34824984
99	AURKA	0.34775120
100	DAPK2	0.33725785

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.27152867
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.81736076
3	Propanoate metabolism_Homo sapiens_hsa00640	3.17582939
4	Butanoate metabolism_Homo sapiens_hsa00650	2.96373497
5	Basal transcription factors_Homo sapiens_hsa03022	2.94972959
6	Sulfur relay system_Homo sapiens_hsa04122	2.60161574
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.53513825
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.50217711
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.42207626
10	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.30268963
11	Fatty acid degradation_Homo sapiens_hsa00071	2.21080879
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.94483930
13	Protein export_Homo sapiens_hsa03060	1.90806697
14	Olfactory transduction_Homo sapiens_hsa04740	1.76443702
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.69915891
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.67263909
17	Fatty acid metabolism_Homo sapiens_hsa01212	1.67162363
18	RNA degradation_Homo sapiens_hsa03018	1.63788616
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.62277040
20	Caffeine metabolism_Homo sapiens_hsa00232	1.55035934
21	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.46757970
22	Nicotine addiction_Homo sapiens_hsa05033	1.46459421
23	beta-Alanine metabolism_Homo sapiens_hsa00410	1.45743487
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45330327
25	Oxidative phosphorylation_Homo sapiens_hsa00190	1.31565007
26	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.25646394
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.22159039
28	ABC transporters_Homo sapiens_hsa02010	1.21260562
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.20266130
30	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.15446979
31	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.15078465
32	Taste transduction_Homo sapiens_hsa04742	1.13206366
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.12602864
34	Peroxisome_Homo sapiens_hsa04146	1.10867299
35	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.09854579
36	Linoleic acid metabolism_Homo sapiens_hsa00591	1.09367342
37	Non-homologous end-joining_Homo sapiens_hsa03450	1.06832366
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.06450760
39	Huntingtons disease_Homo sapiens_hsa05016	1.05749670
40	Phototransduction_Homo sapiens_hsa04744	1.03340189
41	Homologous recombination_Homo sapiens_hsa03440	1.03060252
42	Nitrogen metabolism_Homo sapiens_hsa00910	1.00963033
43	Fat digestion and absorption_Homo sapiens_hsa04975	1.00850876
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.99226110
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95200268
46	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.91279023
47	Insulin secretion_Homo sapiens_hsa04911	0.89545696
48	Parkinsons disease_Homo sapiens_hsa05012	0.88679431
49	Serotonergic synapse_Homo sapiens_hsa04726	0.82691190
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82211601
51	Nucleotide excision repair_Homo sapiens_hsa03420	0.80010637
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.79220719
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.76239506
54	Morphine addiction_Homo sapiens_hsa05032	0.76105283
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73051482
56	Fatty acid elongation_Homo sapiens_hsa00062	0.72275667
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71639709
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.70872387
59	Oocyte meiosis_Homo sapiens_hsa04114	0.70219003
60	Retinol metabolism_Homo sapiens_hsa00830	0.66214144
61	Circadian rhythm_Homo sapiens_hsa04710	0.65166494
62	Basal cell carcinoma_Homo sapiens_hsa05217	0.62686158
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.62478729
64	Cell cycle_Homo sapiens_hsa04110	0.62376121
65	PPAR signaling pathway_Homo sapiens_hsa03320	0.61822859
66	Glutamatergic synapse_Homo sapiens_hsa04724	0.60730382
67	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.58966785
68	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.58886160
69	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.58857898
70	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55139408
71	Alzheimers disease_Homo sapiens_hsa05010	0.54763185
72	GABAergic synapse_Homo sapiens_hsa04727	0.54382231
73	RNA transport_Homo sapiens_hsa03013	0.53404255
74	Mineral absorption_Homo sapiens_hsa04978	0.50976149
75	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.50516623
76	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.50029427
77	Tyrosine metabolism_Homo sapiens_hsa00350	0.48484112
78	Metabolic pathways_Homo sapiens_hsa01100	0.48174278
79	Pyruvate metabolism_Homo sapiens_hsa00620	0.46082352
80	Circadian entrainment_Homo sapiens_hsa04713	0.43845637
81	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.42457897
82	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.40883324
83	Glutathione metabolism_Homo sapiens_hsa00480	0.40648572
84	Lysine degradation_Homo sapiens_hsa00310	0.40476598
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.39620924
86	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.37383324
87	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.35099551
88	Regulation of autophagy_Homo sapiens_hsa04140	0.34756284
89	Dopaminergic synapse_Homo sapiens_hsa04728	0.34318449
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.34231814
91	Axon guidance_Homo sapiens_hsa04360	0.34189712
92	Calcium signaling pathway_Homo sapiens_hsa04020	0.33356995
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.29550168
94	Mismatch repair_Homo sapiens_hsa03430	0.28824748
95	p53 signaling pathway_Homo sapiens_hsa04115	0.28340013
96	Long-term depression_Homo sapiens_hsa04730	0.24602599
97	Base excision repair_Homo sapiens_hsa03410	0.24598620
98	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.23901059
99	Cholinergic synapse_Homo sapiens_hsa04725	0.23653876
100	Bile secretion_Homo sapiens_hsa04976	0.23045301

RPL35P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »