RPL35P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)9.77501385
2ribosomal small subunit biogenesis (GO:0042274)9.50394694
3ribosomal small subunit assembly (GO:0000028)9.43194487
4viral transcription (GO:0019083)8.19441459
5translational termination (GO:0006415)7.82176502
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.75574170
7substrate-independent telencephalic tangential migration (GO:0021826)6.72615732
8substrate-independent telencephalic tangential interneuron migration (GO:0021843)6.72615732
9cotranslational protein targeting to membrane (GO:0006613)6.66168286
10protein targeting to ER (GO:0045047)6.60769494
11translational elongation (GO:0006414)6.49534565
12establishment of protein localization to endoplasmic reticulum (GO:0072599)6.40952225
13protein localization to endoplasmic reticulum (GO:0070972)6.29968807
14cellular protein complex disassembly (GO:0043624)5.92928908
15chaperone-mediated protein transport (GO:0072321)5.89766700
16viral life cycle (GO:0019058)5.81772346
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.72781480
18ATP synthesis coupled proton transport (GO:0015986)5.51657373
19energy coupled proton transport, down electrochemical gradient (GO:0015985)5.51657373
20translational initiation (GO:0006413)5.46362686
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.12194445
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.99030384
23protein complex disassembly (GO:0043241)4.92794184
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.86570535
25macromolecular complex disassembly (GO:0032984)4.71467663
26translation (GO:0006412)4.57586178
27protein targeting to membrane (GO:0006612)4.56985124
28respiratory electron transport chain (GO:0022904)4.49243013
29electron transport chain (GO:0022900)4.40401805
30positive regulation of respiratory burst (GO:0060267)4.35586866
31nonmotile primary cilium assembly (GO:0035058)4.33896666
32tongue development (GO:0043586)4.31848749
33ribonucleoprotein complex biogenesis (GO:0022613)4.24279824
34ribosomal large subunit biogenesis (GO:0042273)4.15691308
35nuclear-transcribed mRNA catabolic process (GO:0000956)4.15481192
36GTP biosynthetic process (GO:0006183)4.00401887
37cellular component biogenesis (GO:0044085)3.93624708
38mRNA catabolic process (GO:0006402)3.90907186
39positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.89452597
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.86239927
41positive regulation of T cell apoptotic process (GO:0070234)3.75362067
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.72090741
43NADH dehydrogenase complex assembly (GO:0010257)3.72090741
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.72090741
45protein complex biogenesis (GO:0070271)3.68902569
46rRNA processing (GO:0006364)3.61063252
47cardiovascular system development (GO:0072358)3.60992105
48UTP biosynthetic process (GO:0006228)3.60131940
49DNA deamination (GO:0045006)3.59571897
50axonemal dynein complex assembly (GO:0070286)3.54797569
51RNA catabolic process (GO:0006401)3.52210364
52mitochondrial respiratory chain complex assembly (GO:0033108)3.51991984
53behavioral response to nicotine (GO:0035095)3.50708665
54UTP metabolic process (GO:0046051)3.50322358
55rRNA metabolic process (GO:0016072)3.49539856
56spliceosomal complex assembly (GO:0000245)3.48629676
57purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.43389085
58L-serine metabolic process (GO:0006563)3.40357734
59protein-cofactor linkage (GO:0018065)3.39892848
60regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.38612243
61purine nucleoside triphosphate biosynthetic process (GO:0009145)3.34155410
62somite development (GO:0061053)3.32909699
63protein targeting to mitochondrion (GO:0006626)3.29666638
64left/right axis specification (GO:0070986)3.25766605
65ATP biosynthetic process (GO:0006754)3.25385042
66establishment of protein localization to mitochondrion (GO:0072655)3.22633518
67establishment of protein localization to membrane (GO:0090150)3.21217347
68protein neddylation (GO:0045116)3.19417849
69DNA damage response, detection of DNA damage (GO:0042769)3.19073722
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14951103
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14951103
72cerebral cortex radially oriented cell migration (GO:0021799)3.14341528
73regulation of cellular respiration (GO:0043457)3.14124640
74protein targeting (GO:0006605)3.13300313
75ribonucleoside triphosphate biosynthetic process (GO:0009201)3.06676675
76hydrogen ion transmembrane transport (GO:1902600)3.01859273
77protein localization to mitochondrion (GO:0070585)2.97479618
78peptidyl-histidine modification (GO:0018202)2.92346894
79establishment of protein localization to organelle (GO:0072594)2.92105343
80CTP metabolic process (GO:0046036)2.90139388
81CTP biosynthetic process (GO:0006241)2.90139388
82ncRNA 3-end processing (GO:0043628)2.88965062
83regulation of mitochondrial translation (GO:0070129)2.88434756
84rRNA modification (GO:0000154)2.87582029
85outer ear morphogenesis (GO:0042473)2.85005127
86regulation of isotype switching to IgG isotypes (GO:0048302)2.83872976
87mature B cell differentiation involved in immune response (GO:0002313)2.83287584
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80234546
89negative regulation of B cell apoptotic process (GO:0002903)2.79401917
90preassembly of GPI anchor in ER membrane (GO:0016254)2.74533500
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73294565
92pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.73107738
93neuron fate determination (GO:0048664)2.71465431
94positive regulation of lymphocyte apoptotic process (GO:0070230)2.70138724
95negative regulation of telomere maintenance (GO:0032205)2.68803434
96proton transport (GO:0015992)2.68170236
97pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.67181232
98pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.64845262
99indolalkylamine metabolic process (GO:0006586)2.63116106
100pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.63018051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.52115685
2EZH2_22144423_ChIP-Seq_EOC_Human5.26842009
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.47726947
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.27107695
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.77089662
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.27872030
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.26856038
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.24223195
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.19555425
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.11009666
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91066114
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.72039837
13VDR_22108803_ChIP-Seq_LS180_Human2.19362305
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11985348
15XRN2_22483619_ChIP-Seq_HELA_Human2.03457567
16VDR_23849224_ChIP-Seq_CD4+_Human2.00316051
17TTF2_22483619_ChIP-Seq_HELA_Human1.86087768
18MYC_18358816_ChIP-ChIP_MESCs_Mouse1.86050003
19IRF1_19129219_ChIP-ChIP_H3396_Human1.83452683
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80589284
21CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.79487389
22GABP_19822575_ChIP-Seq_HepG2_Human1.76884240
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76431828
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74877130
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73002234
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.54774121
27FOXP3_21729870_ChIP-Seq_TREG_Human1.54452164
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53716474
29ZNF274_21170338_ChIP-Seq_K562_Hela1.50533615
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46675105
31MYC_18940864_ChIP-ChIP_HL60_Human1.44558415
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43638531
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38525602
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37898981
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36816555
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.35672797
37SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33248048
38ELK1_19687146_ChIP-ChIP_HELA_Human1.33221270
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31264760
40TP53_22573176_ChIP-Seq_HFKS_Human1.30028409
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29869318
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.18336052
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18277683
44DCP1A_22483619_ChIP-Seq_HELA_Human1.17118857
45RNF2_27304074_Chip-Seq_NSC_Mouse1.17010915
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.15652936
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.15144884
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12958775
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.12687908
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12212038
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.12209681
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.10559563
53FUS_26573619_Chip-Seq_HEK293_Human1.07793529
54TAF2_19829295_ChIP-Seq_ESCs_Human1.07514717
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06581932
56FOXP1_21924763_ChIP-Seq_HESCs_Human1.05628491
57NCOR_22424771_ChIP-Seq_293T_Human1.05473655
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03909256
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03817755
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02669058
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02286854
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02072931
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01417437
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.01233326
65SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01058745
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00899088
67NANOG_20526341_ChIP-Seq_ESCs_Human1.00793180
68ERA_21632823_ChIP-Seq_H3396_Human0.99803391
69YY1_22570637_ChIP-Seq_MALME-3M_Human0.99038205
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98206348
71CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97996720
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96888232
73BCL6_27268052_Chip-Seq_Bcells_Human0.95713005
74YY1_21170310_ChIP-Seq_MESCs_Mouse0.95616854
75ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94631307
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92553568
77EWS_26573619_Chip-Seq_HEK293_Human0.92116574
78SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90689288
79GATA3_21878914_ChIP-Seq_MCF-7_Human0.90657926
80CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89435792
81AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88831634
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88009656
83REST_21632747_ChIP-Seq_MESCs_Mouse0.85834520
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85624883
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84659075
86TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83328097
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82804536
88GATA3_21867929_ChIP-Seq_TH1_Mouse0.82753672
89PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82292498
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.82155243
91P53_21459846_ChIP-Seq_SAOS-2_Human0.82046362
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81742124
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.79766456
94JARID2_20075857_ChIP-Seq_MESCs_Mouse0.77060323
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.77024433
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77010750
97SOX2_16153702_ChIP-ChIP_HESCs_Human0.76827163
98AR_20517297_ChIP-Seq_VCAP_Human0.76426345
99CIITA_25753668_ChIP-Seq_RAJI_Human0.75331729
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.74038129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation8.87872910
2MP0006292_abnormal_olfactory_placode5.16862362
3MP0008789_abnormal_olfactory_epithelium2.98801527
4MP0003646_muscle_fatigue2.97221158
5MP0003878_abnormal_ear_physiology2.71162982
6MP0005377_hearing/vestibular/ear_phenot2.71162982
7MP0005499_abnormal_olfactory_system2.66161394
8MP0005394_taste/olfaction_phenotype2.66161394
9MP0002837_dystrophic_cardiac_calcinosis2.60399419
10MP0004142_abnormal_muscle_tone2.57675964
11MP0009053_abnormal_anal_canal2.26611676
12MP0003136_yellow_coat_color2.17717060
13MP0000049_abnormal_middle_ear2.02580994
14MP0002653_abnormal_ependyma_morphology1.96430621
15MP0005174_abnormal_tail_pigmentation1.88332698
16MP0001293_anophthalmia1.83900051
17MP0005670_abnormal_white_adipose1.81109417
18MP0001853_heart_inflammation1.76391324
19MP0003880_abnormal_central_pattern1.74109963
20MP0002277_abnormal_respiratory_mucosa1.69094776
21MP0002138_abnormal_hepatobiliary_system1.67450492
22MP0003122_maternal_imprinting1.66844308
23MP0006276_abnormal_autonomic_nervous1.57627510
24MP0004885_abnormal_endolymph1.57584957
25MP0001485_abnormal_pinna_reflex1.57419622
26MP0005360_urolithiasis1.54390985
27MP0003938_abnormal_ear_development1.46683126
28MP0002938_white_spotting1.39160486
29MP0001968_abnormal_touch/_nociception1.37643851
30MP0003806_abnormal_nucleotide_metabolis1.32047953
31MP0002234_abnormal_pharynx_morphology1.31708661
32MP0002736_abnormal_nociception_after1.30490425
33MP0001529_abnormal_vocalization1.27868076
34MP0002095_abnormal_skin_pigmentation1.25081049
35MP0002876_abnormal_thyroid_physiology1.23423681
36MP0000678_abnormal_parathyroid_gland1.21213510
37MP0000778_abnormal_nervous_system1.20835873
38MP0004742_abnormal_vestibular_system1.19517001
39MP0004145_abnormal_muscle_electrophysio1.19039977
40MP0002249_abnormal_larynx_morphology1.19006374
41MP0002233_abnormal_nose_morphology1.18820744
42MP0005084_abnormal_gallbladder_morpholo1.17408202
43MP0003567_abnormal_fetal_cardiomyocyte1.16628390
44MP0002272_abnormal_nervous_system1.14184309
45MP0004147_increased_porphyrin_level1.13644220
46MP0001188_hyperpigmentation1.10385688
47MP0010030_abnormal_orbit_morphology1.08924337
48MP0002160_abnormal_reproductive_system1.08801803
49MP0004133_heterotaxia1.08200097
50MP0003186_abnormal_redox_activity1.08171852
51MP0001905_abnormal_dopamine_level1.07893661
52MP0005551_abnormal_eye_electrophysiolog1.05593198
53MP0000566_synostosis1.05230701
54MP0003123_paternal_imprinting1.03447882
55MP0003121_genomic_imprinting1.03369329
56MP0005646_abnormal_pituitary_gland1.03000296
57MP0006036_abnormal_mitochondrial_physio1.02631605
58MP0000631_abnormal_neuroendocrine_gland0.98689093
59MP0008995_early_reproductive_senescence0.97027497
60MP0008872_abnormal_physiological_respon0.96551913
61MP0000569_abnormal_digit_pigmentation0.94173301
62MP0001986_abnormal_taste_sensitivity0.92347134
63MP0003879_abnormal_hair_cell0.90592642
64MP0002184_abnormal_innervation0.89453211
65MP0005195_abnormal_posterior_eye0.88145476
66MP0000026_abnormal_inner_ear0.87310560
67MP0001440_abnormal_grooming_behavior0.84583171
68MP0001984_abnormal_olfaction0.83947827
69MP0005332_abnormal_amino_acid0.83487982
70MP0008877_abnormal_DNA_methylation0.81888598
71MP0003755_abnormal_palate_morphology0.81658787
72MP0005085_abnormal_gallbladder_physiolo0.80347838
73MP0003937_abnormal_limbs/digits/tail_de0.79927412
74MP0000516_abnormal_urinary_system0.77333588
75MP0005367_renal/urinary_system_phenotyp0.77333588
76MP0005389_reproductive_system_phenotype0.76870252
77MP0000955_abnormal_spinal_cord0.76760792
78MP0008775_abnormal_heart_ventricle0.76106882
79MP0002557_abnormal_social/conspecific_i0.75553144
80MP0009250_abnormal_appendicular_skeleto0.74547854
81MP0002177_abnormal_outer_ear0.73474332
82MP0001324_abnormal_eye_pigmentation0.73432878
83MP0003942_abnormal_urinary_system0.71683807
84MP0002752_abnormal_somatic_nervous0.70265352
85MP0002102_abnormal_ear_morphology0.70053055
86MP0009046_muscle_twitch0.69480119
87MP0005636_abnormal_mineral_homeostasis0.68651887
88MP0001486_abnormal_startle_reflex0.67406769
89MP0009745_abnormal_behavioral_response0.67385303
90MP0008875_abnormal_xenobiotic_pharmacok0.67219101
91MP0002733_abnormal_thermal_nociception0.65864391
92MP0000604_amyloidosis0.62859515
93MP0003786_premature_aging0.62081405
94MP0002210_abnormal_sex_determination0.61219689
95MP0001963_abnormal_hearing_physiology0.60615217
96MP0001286_abnormal_eye_development0.59289345
97MP0002067_abnormal_sensory_capabilities0.59093848
98MP0002572_abnormal_emotion/affect_behav0.58212346
99MP0006035_abnormal_mitochondrial_morpho0.58091010
100MP0002928_abnormal_bile_duct0.57776037

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)7.01881961
2Acute necrotizing encephalopathy (HP:0006965)5.14011563
3Abnormality of cells of the erythroid lineage (HP:0012130)4.73984865
4Aplasia/Hypoplasia of the sacrum (HP:0008517)4.71313021
5Molar tooth sign on MRI (HP:0002419)4.65225890
6Abnormality of midbrain morphology (HP:0002418)4.65225890
7Acute encephalopathy (HP:0006846)4.63028725
8Abnormal mitochondria in muscle tissue (HP:0008316)4.48028137
9Macrocytic anemia (HP:0001972)4.27690073
10Progressive macrocephaly (HP:0004481)4.08497493
11Mitochondrial inheritance (HP:0001427)3.90060835
1211 pairs of ribs (HP:0000878)3.70953070
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.61939371
14Cerebral edema (HP:0002181)3.44104042
15Abnormal number of erythroid precursors (HP:0012131)3.41171565
16Increased CSF lactate (HP:0002490)3.40500981
17Increased hepatocellular lipid droplets (HP:0006565)3.20891365
18Septo-optic dysplasia (HP:0100842)3.18863684
19Absent thumb (HP:0009777)3.17914000
20Pallor (HP:0000980)3.11725207
21Rib fusion (HP:0000902)3.01178337
22Absent/shortened dynein arms (HP:0200106)2.97479438
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.97479438
24Renal Fanconi syndrome (HP:0001994)2.92325375
25Nephronophthisis (HP:0000090)2.90052376
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.84992006
27Lipid accumulation in hepatocytes (HP:0006561)2.77339444
28Hepatic necrosis (HP:0002605)2.71022487
29Partial duplication of thumb phalanx (HP:0009944)2.65606245
30Hypoplasia of the radius (HP:0002984)2.64532354
31Hepatocellular necrosis (HP:0001404)2.62326960
32Colon cancer (HP:0003003)2.56189578
33Abnormal rod and cone electroretinograms (HP:0008323)2.54361385
34Missing ribs (HP:0000921)2.50283969
35Stenosis of the external auditory canal (HP:0000402)2.46755442
36Hyperglycinemia (HP:0002154)2.44132071
37Leukodystrophy (HP:0002415)2.39296890
38Abnormal respiratory epithelium morphology (HP:0012253)2.38002670
39Abnormal respiratory motile cilium morphology (HP:0005938)2.38002670
40Increased intramyocellular lipid droplets (HP:0012240)2.35546867
41Tubular atrophy (HP:0000092)2.32490352
42Supernumerary spleens (HP:0009799)2.30060523
43Abnormal ciliary motility (HP:0012262)2.30007494
44Sclerocornea (HP:0000647)2.23555503
45Optic disc pallor (HP:0000543)2.23544619
46Abnormal respiratory motile cilium physiology (HP:0012261)2.22159936
47Lethargy (HP:0001254)2.21301377
48Myokymia (HP:0002411)2.21162152
49Abnormality of the 4th metacarpal (HP:0010012)2.20180604
50Abnormality of the diencephalon (HP:0010662)2.19840222
51Partial duplication of the phalanx of hand (HP:0009999)2.18374888
52Abnormality of the renal medulla (HP:0100957)2.14409657
53Maternal diabetes (HP:0009800)2.13747145
54Lactic acidosis (HP:0003128)2.13317476
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09656507
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09656507
57Forearm undergrowth (HP:0009821)2.08964609
58Abnormality of urine glucose concentration (HP:0011016)2.08263712
59Glycosuria (HP:0003076)2.08263712
60Depressed nasal ridge (HP:0000457)2.08047715
61Anencephaly (HP:0002323)2.06801372
62Pancreatic fibrosis (HP:0100732)2.05879441
63Type II lissencephaly (HP:0007260)2.03476229
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03011564
65Hyperphosphaturia (HP:0003109)2.00437635
66Abnormal drinking behavior (HP:0030082)1.97577813
67Polydipsia (HP:0001959)1.97577813
68Pendular nystagmus (HP:0012043)1.96960133
69Absent septum pellucidum (HP:0001331)1.95552305
70Increased serum lactate (HP:0002151)1.95363831
71Respiratory failure (HP:0002878)1.94864252
723-Methylglutaconic aciduria (HP:0003535)1.93073954
73Abnormality of the metopic suture (HP:0005556)1.92928468
74Triphalangeal thumb (HP:0001199)1.90377376
75Medial flaring of the eyebrow (HP:0010747)1.89140084
76Exercise intolerance (HP:0003546)1.88586893
77Increased muscle lipid content (HP:0009058)1.87426531
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87301305
79Abnormality of alanine metabolism (HP:0010916)1.87301305
80Hyperalaninemia (HP:0003348)1.87301305
81True hermaphroditism (HP:0010459)1.86706992
82Abnormality of renal resorption (HP:0011038)1.85770365
83Renal dysplasia (HP:0000110)1.85116446
84Elevated erythrocyte sedimentation rate (HP:0003565)1.85002111
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83450082
86Optic nerve hypoplasia (HP:0000609)1.82306418
87Generalized aminoaciduria (HP:0002909)1.81271073
88Pancreatic cysts (HP:0001737)1.81230574
89Hyperglycinuria (HP:0003108)1.80967738
90Symphalangism affecting the phalanges of the hand (HP:0009773)1.80948237
91Hip dysplasia (HP:0001385)1.79496865
92Fibular hypoplasia (HP:0003038)1.77904155
93Exertional dyspnea (HP:0002875)1.77717837
94Abnormal number of incisors (HP:0011064)1.77573112
95Respiratory difficulties (HP:0002880)1.77394728
96Duplication of thumb phalanx (HP:0009942)1.77248771
97Asplenia (HP:0001746)1.75954310
98Abnormality of the middle phalanges of the toes (HP:0010183)1.75176263
99Constricted visual fields (HP:0001133)1.74964316
100Abnormal hemoglobin (HP:0011902)1.74234344

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.21389869
2WNK43.55923352
3MAP3K93.23663352
4CASK2.76595053
5DYRK22.47814836
6BCKDK2.45680617
7STK162.36443020
8ARAF2.35738816
9STK392.31107194
10PINK12.14453440
11LRRK22.08600185
12LIMK12.08257135
13EPHB22.03058685
14MAP3K122.02306438
15PDK22.02194871
16BRAF1.82979176
17TRIM281.81086350
18TLK11.77084962
19SRPK11.68107762
20PAK31.64339008
21GRK11.51749574
22OXSR11.39421703
23ADRBK21.34009764
24TIE11.32638994
25CDC71.32392837
26EPHA41.30488125
27PRKCG1.29132703
28MAP3K131.27450987
29MAP2K71.25585138
30WNK31.22299657
31MAP3K111.17243048
32NUAK11.12454541
33CSNK1E1.09351246
34CAMK11.08857770
35NTRK21.06458378
36PIM21.04998670
37BRSK11.01836149
38CSNK2A21.00301080
39MST40.97651358
40DAPK30.95489768
41FRK0.92994720
42TEC0.92555007
43ABL20.90227152
44INSRR0.87295238
45ATR0.83947481
46WNK10.83774429
47MYLK0.82994037
48PLK10.81533519
49PRKCQ0.79038070
50PLK40.77731401
51AURKB0.76391474
52PRKACA0.75082317
53NME10.74639972
54OBSCN0.74338387
55TXK0.74148526
56BTK0.73171356
57ILK0.72638829
58AURKA0.70980132
59RPS6KA60.70863389
60MARK10.69594941
61PIK3CA0.68892745
62VRK20.68843544
63TYRO30.66442071
64CCNB10.64947305
65ICK0.64814014
66MAP2K60.64632461
67ZAK0.63684093
68CSNK2A10.62697711
69MAPK130.61876097
70PHKG20.61318252
71PHKG10.61318252
72NTRK10.59649600
73MAPK150.57986119
74MAP2K40.56664821
75ADRBK10.56604333
76RPS6KA50.56200186
77MOS0.53656026
78CAMK2A0.53143033
79MINK10.52220829
80CHEK10.51784376
81PAK20.51337846
82DMPK0.49997396
83PTK2B0.49809324
84VRK10.49690796
85CSNK1A10.48089699
86CAMKK10.46075744
87IKBKB0.43543063
88PRKCA0.43286363
89RPS6KC10.43006293
90RPS6KL10.43006293
91SGK10.41048113
92PRKCI0.38183669
93STK110.37589646
94PRKCD0.37145073
95TAF10.36844087
96NEK10.36840839
97MUSK0.36266559
98AKT20.33086342
99PIM10.31781951
100BMPR1B0.31655984

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.73758848
2Oxidative phosphorylation_Homo sapiens_hsa001904.43314839
3Parkinsons disease_Homo sapiens_hsa050123.80195363
4Huntingtons disease_Homo sapiens_hsa050162.80766647
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.75392133
6Alzheimers disease_Homo sapiens_hsa050102.67092183
7Asthma_Homo sapiens_hsa053102.37432412
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.31368896
9Cardiac muscle contraction_Homo sapiens_hsa042602.16955294
10Protein export_Homo sapiens_hsa030601.96205516
11One carbon pool by folate_Homo sapiens_hsa006701.77493735
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76537597
13RNA polymerase_Homo sapiens_hsa030201.70715528
14Homologous recombination_Homo sapiens_hsa034401.68825111
15Proteasome_Homo sapiens_hsa030501.66042506
16Linoleic acid metabolism_Homo sapiens_hsa005911.60670383
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.57020170
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46294668
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.45424602
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43115607
21Allograft rejection_Homo sapiens_hsa053301.41490371
22Mismatch repair_Homo sapiens_hsa034301.39319586
23Sulfur metabolism_Homo sapiens_hsa009201.39223796
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.36645561
25Autoimmune thyroid disease_Homo sapiens_hsa053201.35534961
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33904619
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31847424
28Nucleotide excision repair_Homo sapiens_hsa034201.31212991
29Pyrimidine metabolism_Homo sapiens_hsa002401.29559271
30Graft-versus-host disease_Homo sapiens_hsa053321.27054296
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24211154
32beta-Alanine metabolism_Homo sapiens_hsa004101.22652935
33Propanoate metabolism_Homo sapiens_hsa006401.20980755
34Tryptophan metabolism_Homo sapiens_hsa003801.19952315
35Type I diabetes mellitus_Homo sapiens_hsa049401.19685918
36Basal transcription factors_Homo sapiens_hsa030221.17677948
37RNA degradation_Homo sapiens_hsa030181.16432561
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13823617
39Sulfur relay system_Homo sapiens_hsa041221.13154362
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.01539655
41Fanconi anemia pathway_Homo sapiens_hsa034601.01315798
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00134135
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97471748
44Peroxisome_Homo sapiens_hsa041460.95888290
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94065463
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90303403
47Spliceosome_Homo sapiens_hsa030400.90160392
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87032434
49DNA replication_Homo sapiens_hsa030300.84085186
50Butanoate metabolism_Homo sapiens_hsa006500.83038450
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.82876467
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82093548
53Retinol metabolism_Homo sapiens_hsa008300.81643359
54Chemical carcinogenesis_Homo sapiens_hsa052040.77726045
55Metabolic pathways_Homo sapiens_hsa011000.76043028
56Regulation of autophagy_Homo sapiens_hsa041400.75130731
57Fatty acid degradation_Homo sapiens_hsa000710.71917175
58Arginine and proline metabolism_Homo sapiens_hsa003300.70120212
59Arachidonic acid metabolism_Homo sapiens_hsa005900.69299948
60RNA transport_Homo sapiens_hsa030130.67061577
61Fat digestion and absorption_Homo sapiens_hsa049750.65481653
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.63943332
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63048767
64Nicotine addiction_Homo sapiens_hsa050330.61408873
65Phenylalanine metabolism_Homo sapiens_hsa003600.59103416
66Arginine biosynthesis_Homo sapiens_hsa002200.57786739
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55475135
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53069087
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51687116
70Tyrosine metabolism_Homo sapiens_hsa003500.51669850
71Purine metabolism_Homo sapiens_hsa002300.51521671
72Phototransduction_Homo sapiens_hsa047440.51101099
73Nitrogen metabolism_Homo sapiens_hsa009100.50257630
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48343483
75Histidine metabolism_Homo sapiens_hsa003400.47108047
76Hedgehog signaling pathway_Homo sapiens_hsa043400.45471599
77Collecting duct acid secretion_Homo sapiens_hsa049660.41954237
78Rheumatoid arthritis_Homo sapiens_hsa053230.39884570
79Fatty acid elongation_Homo sapiens_hsa000620.38359975
80Biosynthesis of amino acids_Homo sapiens_hsa012300.37188159
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35701384
82Basal cell carcinoma_Homo sapiens_hsa052170.34117691
83Ether lipid metabolism_Homo sapiens_hsa005650.33705691
84Staphylococcus aureus infection_Homo sapiens_hsa051500.33634128
85Mineral absorption_Homo sapiens_hsa049780.32704660
86Pyruvate metabolism_Homo sapiens_hsa006200.32059543
87Steroid biosynthesis_Homo sapiens_hsa001000.31183232
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26693045
89Folate biosynthesis_Homo sapiens_hsa007900.26236492
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25632522
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25571861
92Systemic lupus erythematosus_Homo sapiens_hsa053220.24727606
93Glutathione metabolism_Homo sapiens_hsa004800.21755308
94Base excision repair_Homo sapiens_hsa034100.20190907
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19959155
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19325792
97Olfactory transduction_Homo sapiens_hsa047400.18668840
98Carbon metabolism_Homo sapiens_hsa012000.18526641
99p53 signaling pathway_Homo sapiens_hsa041150.17721822
100Vitamin digestion and absorption_Homo sapiens_hsa049770.17511815

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