RPL35P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.24804800
2viral transcription (GO:0019083)7.88263284
3translational termination (GO:0006415)7.57614879
4ribosomal small subunit biogenesis (GO:0042274)7.55568517
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.61501162
6cotranslational protein targeting to membrane (GO:0006613)6.56727450
7protein targeting to ER (GO:0045047)6.52807514
8translational elongation (GO:0006414)6.40945264
9establishment of protein localization to endoplasmic reticulum (GO:0072599)6.21276202
10protein localization to endoplasmic reticulum (GO:0070972)6.13720030
11ATP synthesis coupled proton transport (GO:0015986)6.01545755
12energy coupled proton transport, down electrochemical gradient (GO:0015985)6.01545755
13maturation of SSU-rRNA (GO:0030490)5.94363089
14cellular protein complex disassembly (GO:0043624)5.72201518
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.67755937
16viral life cycle (GO:0019058)5.66727605
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.52850222
18translational initiation (GO:0006413)5.33350021
19protein complex disassembly (GO:0043241)4.83336563
20establishment of protein localization to mitochondrial membrane (GO:0090151)4.81724469
21macromolecular complex disassembly (GO:0032984)4.63302782
22ribosomal large subunit biogenesis (GO:0042273)4.56932069
23chaperone-mediated protein transport (GO:0072321)4.53276483
24translation (GO:0006412)4.40006240
25protein targeting to membrane (GO:0006612)4.36796789
26water-soluble vitamin biosynthetic process (GO:0042364)4.30236533
27DNA deamination (GO:0045006)4.15490050
28positive regulation of respiratory burst (GO:0060267)4.03199912
29nuclear-transcribed mRNA catabolic process (GO:0000956)4.02533836
30behavioral response to nicotine (GO:0035095)3.96349106
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96205899
32protein neddylation (GO:0045116)3.94175349
33mRNA catabolic process (GO:0006402)3.87023002
34respiratory electron transport chain (GO:0022904)3.82585865
35electron transport chain (GO:0022900)3.82477592
36ribonucleoprotein complex biogenesis (GO:0022613)3.69518535
37protein complex biogenesis (GO:0070271)3.64805999
38negative regulation of telomere maintenance (GO:0032205)3.62994026
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.55592282
40NADH dehydrogenase complex assembly (GO:0010257)3.55592282
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55592282
42RNA catabolic process (GO:0006401)3.55167466
43GTP biosynthetic process (GO:0006183)3.55132990
44cellular component biogenesis (GO:0044085)3.51942298
45hypothalamus development (GO:0021854)3.42210831
46purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.34376233
47purine nucleoside triphosphate biosynthetic process (GO:0009145)3.32426871
48mitochondrial respiratory chain complex assembly (GO:0033108)3.30458499
49ATP biosynthetic process (GO:0006754)3.27821468
50telomere maintenance via telomerase (GO:0007004)3.27147552
51cellular response to interferon-beta (GO:0035458)3.23220430
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21385540
53tongue development (GO:0043586)3.19854583
54ubiquinone biosynthetic process (GO:0006744)3.18009365
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16013999
56cell proliferation in forebrain (GO:0021846)3.15970345
57UTP biosynthetic process (GO:0006228)3.11895918
58UTP metabolic process (GO:0046051)3.09117914
59protein-cofactor linkage (GO:0018065)3.06571570
60hydrogen ion transmembrane transport (GO:1902600)3.05887393
61respiratory chain complex IV assembly (GO:0008535)3.01230304
62neuron fate determination (GO:0048664)2.99497726
63cardiovascular system development (GO:0072358)2.98590972
64tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.93595930
65RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.93595930
66ribonucleoside triphosphate biosynthetic process (GO:0009201)2.87400291
67establishment of protein localization to membrane (GO:0090150)2.86148094
68protein polyglutamylation (GO:0018095)2.84871847
69auditory receptor cell differentiation (GO:0042491)2.81489175
70rRNA processing (GO:0006364)2.80478039
71rRNA catabolic process (GO:0016075)2.80069403
72cytidine deamination (GO:0009972)2.79875674
73cytidine metabolic process (GO:0046087)2.79875674
74cytidine catabolic process (GO:0006216)2.79875674
75ubiquinone metabolic process (GO:0006743)2.79874833
76positive regulation of prostaglandin secretion (GO:0032308)2.79736805
77rRNA metabolic process (GO:0016072)2.79550859
78proton transport (GO:0015992)2.79199148
79regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.78837322
80protein targeting (GO:0006605)2.78017750
81hydrogen transport (GO:0006818)2.77039731
82nucleoside diphosphate catabolic process (GO:0009134)2.73672965
83nonmotile primary cilium assembly (GO:0035058)2.72354072
84substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.72137914
85substrate-independent telencephalic tangential migration (GO:0021826)2.72137914
86ncRNA catabolic process (GO:0034661)2.66545552
87peptidyl-histidine modification (GO:0018202)2.66511091
88detection of light stimulus involved in sensory perception (GO:0050962)2.63511252
89detection of light stimulus involved in visual perception (GO:0050908)2.63511252
90detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61518215
91quinone biosynthetic process (GO:1901663)2.60926352
92cytochrome complex assembly (GO:0017004)2.58156198
93DNA excision (GO:0044349)2.55154368
94nucleotide-excision repair, DNA damage removal (GO:0000718)2.55154368
95pattern specification involved in kidney development (GO:0061004)2.53540019
96cardiac left ventricle morphogenesis (GO:0003214)2.53317685
97cellular response to exogenous dsRNA (GO:0071360)2.50411365
98positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.49614016
99positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.49315542
100transcription elongation from RNA polymerase III promoter (GO:0006385)2.47811744

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.97977453
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.14445736
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.13237971
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.56214070
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.36245503
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06811896
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90806805
8VDR_22108803_ChIP-Seq_LS180_Human2.84425405
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.78268099
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.74442513
11IRF1_19129219_ChIP-ChIP_H3396_Human2.66375103
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45348054
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.29291900
14VDR_23849224_ChIP-Seq_CD4+_Human2.25261857
15ELK1_19687146_ChIP-ChIP_HELA_Human2.19248171
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14248249
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.13507351
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.10040279
19ZNF274_21170338_ChIP-Seq_K562_Hela2.03843841
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01347010
21IGF1R_20145208_ChIP-Seq_DFB_Human1.95889058
22FOXP3_21729870_ChIP-Seq_TREG_Human1.85398476
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70779986
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65155797
25MYC_18940864_ChIP-ChIP_HL60_Human1.64843478
26TTF2_22483619_ChIP-Seq_HELA_Human1.62964062
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62542913
28XRN2_22483619_ChIP-Seq_HELA_Human1.61641305
29TP53_22573176_ChIP-Seq_HFKS_Human1.57157767
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53107541
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.49835239
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44990475
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44559793
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42740584
35CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42314710
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.41225785
37EWS_26573619_Chip-Seq_HEK293_Human1.40773048
38CIITA_25753668_ChIP-Seq_RAJI_Human1.29705204
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29499729
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26738646
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.26002531
42ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25666142
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25076944
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23410777
45TAF2_19829295_ChIP-Seq_ESCs_Human1.22736875
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20329112
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.19672181
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19304408
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.18247052
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.16215270
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16215270
52GABP_19822575_ChIP-Seq_HepG2_Human1.14960229
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14697803
54SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13288199
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13054123
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11916297
57CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11704323
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.11439584
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11360092
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.11052109
61TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10637785
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10235824
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09693590
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.08447403
65ERA_21632823_ChIP-Seq_H3396_Human1.07267590
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06111638
67STAT1_20625510_ChIP-Seq_HELA_Human1.05923560
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04509216
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02410277
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01089038
71NCOR_22424771_ChIP-Seq_293T_Human1.00910277
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98762663
73NANOG_20526341_ChIP-Seq_ESCs_Human0.96016530
74MYC_19829295_ChIP-Seq_ESCs_Human0.95991235
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95693325
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94591099
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94486587
78SOX2_19829295_ChIP-Seq_ESCs_Human0.93381593
79NANOG_19829295_ChIP-Seq_ESCs_Human0.93381593
80AR_20517297_ChIP-Seq_VCAP_Human0.92792129
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92661337
82PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91186813
83HOXB7_26014856_ChIP-Seq_BT474_Human0.91078745
84FOXH1_21741376_ChIP-Seq_ESCs_Human0.89914538
85P53_21459846_ChIP-Seq_SAOS-2_Human0.89239815
86CBX2_27304074_Chip-Seq_ESCs_Mouse0.89102943
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88973496
88P300_19829295_ChIP-Seq_ESCs_Human0.88672286
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88423696
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86359498
91JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85903740
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.85442053
93EZH2_27294783_Chip-Seq_ESCs_Mouse0.84009535
94E2F1_18555785_ChIP-Seq_MESCs_Mouse0.83910345
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.83514360
96PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82867164
97TP63_19390658_ChIP-ChIP_HaCaT_Human0.79801996
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.78471133
99DCP1A_22483619_ChIP-Seq_HELA_Human0.77341871
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.76825269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.77549016
2MP0006292_abnormal_olfactory_placode4.74986544
3MP0002138_abnormal_hepatobiliary_system4.09727306
4MP0001348_abnormal_lacrimal_gland3.18675451
5MP0008789_abnormal_olfactory_epithelium2.80504572
6MP0005394_taste/olfaction_phenotype2.71751802
7MP0005499_abnormal_olfactory_system2.71751802
8MP0001293_anophthalmia2.64570234
9MP0003878_abnormal_ear_physiology2.36736673
10MP0005377_hearing/vestibular/ear_phenot2.36736673
11MP0010030_abnormal_orbit_morphology2.33415077
12MP0004145_abnormal_muscle_electrophysio2.26383297
13MP0003646_muscle_fatigue2.14832627
14MP0002102_abnormal_ear_morphology2.03445082
15MP0001968_abnormal_touch/_nociception2.02215708
16MP0008872_abnormal_physiological_respon1.89929947
17MP0004142_abnormal_muscle_tone1.88470215
18MP0002638_abnormal_pupillary_reflex1.87934631
19MP0002938_white_spotting1.78694885
20MP0008875_abnormal_xenobiotic_pharmacok1.73573052
21MP0003806_abnormal_nucleotide_metabolis1.73257973
22MP0001485_abnormal_pinna_reflex1.63239847
23MP0005645_abnormal_hypothalamus_physiol1.59094290
24MP0001986_abnormal_taste_sensitivity1.53944435
25MP0002095_abnormal_skin_pigmentation1.51120791
26MP0008058_abnormal_DNA_repair1.50041969
27MP0001984_abnormal_olfaction1.49659393
28MP0002736_abnormal_nociception_after1.48289780
29MP0001905_abnormal_dopamine_level1.43444948
30MP0005174_abnormal_tail_pigmentation1.43318795
31MP0008877_abnormal_DNA_methylation1.41835888
32MP0002653_abnormal_ependyma_morphology1.39137717
33MP0000685_abnormal_immune_system1.38629130
34MP0003880_abnormal_central_pattern1.36501726
35MP0003879_abnormal_hair_cell1.33401908
36MP0003787_abnormal_imprinting1.33046213
37MP0003183_abnormal_peptide_metabolism1.31643935
38MP0002277_abnormal_respiratory_mucosa1.23256778
39MP0000778_abnormal_nervous_system1.22511294
40MP0002272_abnormal_nervous_system1.22495864
41MP0002837_dystrophic_cardiac_calcinosis1.19537113
42MP0002160_abnormal_reproductive_system1.15678737
43MP0003123_paternal_imprinting1.14757521
44MP0005379_endocrine/exocrine_gland_phen1.11799632
45MP0003136_yellow_coat_color1.10958591
46MP0002733_abnormal_thermal_nociception1.10842773
47MP0005551_abnormal_eye_electrophysiolog1.10452542
48MP0000569_abnormal_digit_pigmentation1.07567705
49MP0001970_abnormal_pain_threshold1.06524489
50MP0001486_abnormal_startle_reflex1.06438784
51MP0003121_genomic_imprinting1.05767786
52MP0002734_abnormal_mechanical_nocicepti1.02604552
53MP0004147_increased_porphyrin_level1.02234180
54MP0004742_abnormal_vestibular_system1.02131518
55MP0005671_abnormal_response_to1.02083154
56MP0003718_maternal_effect1.01920282
57MP0004885_abnormal_endolymph1.01855947
58MP0005075_abnormal_melanosome_morpholog1.01383582
59MP0005195_abnormal_posterior_eye1.01316008
60MP0001835_abnormal_antigen_presentation0.99277310
61MP0003938_abnormal_ear_development0.99177241
62MP0005389_reproductive_system_phenotype0.98615847
63MP0001873_stomach_inflammation0.93727510
64MP0009745_abnormal_behavioral_response0.93104582
65MP0004043_abnormal_pH_regulation0.91640976
66MP0006276_abnormal_autonomic_nervous0.91455152
67MP0002876_abnormal_thyroid_physiology0.91332289
68MP0002184_abnormal_innervation0.89236595
69MP0006036_abnormal_mitochondrial_physio0.88981811
70MP0001440_abnormal_grooming_behavior0.88830386
71MP0001324_abnormal_eye_pigmentation0.88405091
72MP0000026_abnormal_inner_ear0.88311750
73MP0002735_abnormal_chemical_nociception0.87906246
74MP0001663_abnormal_digestive_system0.86313624
75MP0003186_abnormal_redox_activity0.86309339
76MP0006054_spinal_hemorrhage0.85848596
77MP0001286_abnormal_eye_development0.83447901
78MP0000015_abnormal_ear_pigmentation0.82941762
79MP0000049_abnormal_middle_ear0.82268053
80MP0000372_irregular_coat_pigmentation0.81886394
81MP0002557_abnormal_social/conspecific_i0.81030638
82MP0003693_abnormal_embryo_hatching0.80922646
83MP0001764_abnormal_homeostasis0.78329251
84MP0005387_immune_system_phenotype0.77429160
85MP0001790_abnormal_immune_system0.77429160
86MP0000427_abnormal_hair_cycle0.76186760
87MP0009764_decreased_sensitivity_to0.75860009
88MP0003252_abnormal_bile_duct0.73236011
89MP0003936_abnormal_reproductive_system0.72395194
90MP0002752_abnormal_somatic_nervous0.70902663
91MP0000613_abnormal_salivary_gland0.70857130
92MP0000566_synostosis0.68879860
93MP0001800_abnormal_humoral_immune0.68342354
94MP0001919_abnormal_reproductive_system0.65976330
95MP0002148_abnormal_hypersensitivity_rea0.65374503
96MP0002163_abnormal_gland_morphology0.63831835
97MP0002234_abnormal_pharynx_morphology0.62971855
98MP0002210_abnormal_sex_determination0.62882452
99MP0005381_digestive/alimentary_phenotyp0.59585052
100MP0006072_abnormal_retinal_apoptosis0.59219500

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.88853202
2Acute necrotizing encephalopathy (HP:0006965)4.36131484
3Acute encephalopathy (HP:0006846)4.06001565
4Rib fusion (HP:0000902)4.03642083
5Septo-optic dysplasia (HP:0100842)3.98699108
6Abnormality of cells of the erythroid lineage (HP:0012130)3.95499225
7Abnormal mitochondria in muscle tissue (HP:0008316)3.74013556
8Supernumerary spleens (HP:0009799)3.51540347
9Pancreatic cysts (HP:0001737)3.49959240
10Progressive macrocephaly (HP:0004481)3.49021322
11Pancreatic fibrosis (HP:0100732)3.47429846
12Aplasia/Hypoplasia of the sacrum (HP:0008517)3.46134325
13Mitochondrial inheritance (HP:0001427)3.42937564
14Macrocytic anemia (HP:0001972)3.39662691
15Increased CSF lactate (HP:0002490)3.27253538
16Bile duct proliferation (HP:0001408)3.22885880
17Abnormal biliary tract physiology (HP:0012439)3.22885880
18Molar tooth sign on MRI (HP:0002419)3.15760469
19Abnormality of midbrain morphology (HP:0002418)3.15760469
20Anophthalmia (HP:0000528)3.13386889
21Congenital, generalized hypertrichosis (HP:0004540)3.09088136
22Aplasia/Hypoplasia of the spleen (HP:0010451)3.00311202
23Hepatocellular necrosis (HP:0001404)2.99772088
24Asplenia (HP:0001746)2.97765504
25Cerebral edema (HP:0002181)2.96219089
26Pallor (HP:0000980)2.92333964
27Hyperglycinemia (HP:0002154)2.86605069
28Stenosis of the external auditory canal (HP:0000402)2.85179698
29Abnormal ciliary motility (HP:0012262)2.74828394
30Abnormal number of erythroid precursors (HP:0012131)2.71783740
31True hermaphroditism (HP:0010459)2.71655557
32Hepatic necrosis (HP:0002605)2.70043056
33Sclerocornea (HP:0000647)2.66236781
34Abnormal rod and cone electroretinograms (HP:0008323)2.65661355
35Elevated erythrocyte sedimentation rate (HP:0003565)2.57157752
36Increased hepatocellular lipid droplets (HP:0006565)2.55608169
37Nephronophthisis (HP:0000090)2.52877693
38Congenital stationary night blindness (HP:0007642)2.48565761
39Optic disc pallor (HP:0000543)2.47922575
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.47231506
41Absent septum pellucidum (HP:0001331)2.43311772
42Colon cancer (HP:0003003)2.42820524
43Medial flaring of the eyebrow (HP:0010747)2.39600703
44Absent thumb (HP:0009777)2.39577636
45Abnormality of the labia minora (HP:0012880)2.38994139
46Lipid accumulation in hepatocytes (HP:0006561)2.35651853
47Abnormality of B cell number (HP:0010975)2.33576186
48B lymphocytopenia (HP:0010976)2.31268103
49Tubular atrophy (HP:0000092)2.27449162
50Abolished electroretinogram (ERG) (HP:0000550)2.26320547
51Abnormality of the prostate (HP:0008775)2.23353544
52Increased serum lactate (HP:0002151)2.20655260
53Hypoplasia of the radius (HP:0002984)2.20347045
54Oligodactyly (hands) (HP:0001180)2.19185373
55Lactic acidosis (HP:0003128)2.11269640
56Concave nail (HP:0001598)2.10721660
57Depressed nasal ridge (HP:0000457)2.10637761
58Lethargy (HP:0001254)2.10491908
59Maternal diabetes (HP:0009800)2.08955444
60Abnormal respiratory motile cilium physiology (HP:0012261)2.08759417
61Abnormality of the renal medulla (HP:0100957)2.08188559
62Horseshoe kidney (HP:0000085)2.06534149
63Oligodactyly (HP:0012165)2.06321364
64Pendular nystagmus (HP:0012043)2.06105353
65Aplasia/Hypoplasia of the ulna (HP:0006495)2.04628198
66Prostate neoplasm (HP:0100787)1.98717930
67Abnormality of the septum pellucidum (HP:0007375)1.98661700
68Renal Fanconi syndrome (HP:0001994)1.98363091
69Abnormality of the renal cortex (HP:0011035)1.98315504
70Abnormal drinking behavior (HP:0030082)1.98253815
71Polydipsia (HP:0001959)1.98253815
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97988122
73Cystic liver disease (HP:0006706)1.97151853
74Oral leukoplakia (HP:0002745)1.94951352
75Constricted visual fields (HP:0001133)1.94381116
763-Methylglutaconic aciduria (HP:0003535)1.94100911
77Hypoplasia of the ulna (HP:0003022)1.94032862
78Occipital encephalocele (HP:0002085)1.93140609
79Exertional dyspnea (HP:0002875)1.91134451
80Forearm undergrowth (HP:0009821)1.90400086
81Aplastic anemia (HP:0001915)1.89307489
82Optic nerve hypoplasia (HP:0000609)1.88242589
83Pancytopenia (HP:0001876)1.87973056
84Leukodystrophy (HP:0002415)1.87354299
85Cleft eyelid (HP:0000625)1.87330252
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85114145
87Fair hair (HP:0002286)1.80252675
88Anencephaly (HP:0002323)1.79528065
89Type 2 muscle fiber atrophy (HP:0003554)1.78606205
90Polyphagia (HP:0002591)1.78551303
9111 pairs of ribs (HP:0000878)1.77875249
92Chronic hepatic failure (HP:0100626)1.77457952
93Congenital hepatic fibrosis (HP:0002612)1.76735053
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.75146851
95Methylmalonic aciduria (HP:0012120)1.72771868
96Respiratory failure (HP:0002878)1.72261713
97Postaxial foot polydactyly (HP:0001830)1.68575015
98Missing ribs (HP:0000921)1.67119089
99Tachypnea (HP:0002789)1.67073054
100Hyperglycinuria (HP:0003108)1.66185361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.09379331
2WNK44.05427367
3GRK12.61302043
4ADRBK22.58655923
5TXK2.43607264
6STK392.39639989
7TLK12.20153626
8BCKDK2.20040158
9CDK192.18811635
10SRPK12.06875164
11VRK12.01757233
12BMPR1B1.92307053
13TAF11.90658058
14CDC71.79708062
15LRRK21.72414582
16PINK11.67934595
17CCNB11.65170352
18OXSR11.62181020
19DYRK21.61380070
20STK161.55381214
21NUAK11.48333638
22STK38L1.41004804
23TAOK31.40724750
24MAP3K41.27525083
25MAP4K11.26088583
26WNK31.25253675
27PLK41.17983856
28TRIM281.14297110
29MAP2K71.10867036
30MAP3K121.08897844
31EIF2AK31.06153867
32PLK21.05133999
33PRKCG1.04095473
34FRK1.03756374
35EIF2AK11.00490551
36TEC0.99660788
37PIK3CA0.99635004
38NME10.97602430
39EPHB20.94277720
40PIM20.92486930
41ARAF0.85208644
42CAMK10.83316858
43WNK10.83242727
44PRKCI0.82931287
45MAPKAPK50.81349465
46MKNK20.79861951
47CDK80.79296202
48SYK0.79277391
49CSNK2A20.78975269
50MST40.78145073
51ADRBK10.76834991
52DAPK30.76458257
53NME20.76099669
54INSRR0.75503396
55ABL20.75168265
56GRK60.74413496
57ITK0.71771179
58CAMKK20.69750685
59BTK0.69059057
60PLK10.68991089
61PDK20.68655373
62PAK30.66213880
63PLK30.64395768
64PHKG20.63306348
65PHKG10.63306348
66PRKCH0.63018283
67MKNK10.61885426
68PRKCQ0.59630331
69PRKCE0.59384275
70NEK10.59286501
71MAP3K110.59192588
72IKBKB0.59107955
73CLK10.55829838
74CSNK1G30.54097301
75TNIK0.53879201
76TIE10.53812433
77ATR0.53718587
78BMPR20.53240440
79PASK0.53048970
80MAPKAPK30.51834696
81EIF2AK20.51737869
82BRD40.51302812
83CSNK1E0.51169622
84ACVR1B0.50891680
85CSNK2A10.49270362
86TGFBR10.49245105
87MAPK130.49186569
88BLK0.48914500
89AURKB0.48404883
90WEE10.48208231
91MARK30.47837386
92RPS6KA50.47236423
93MAP2K40.46928582
94CSNK1G10.46763246
95DAPK10.45695619
96STK30.45222143
97EPHA40.44853361
98STK240.44186700
99PRKACA0.43891243
100GRK50.43531620

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.77839560
2Asthma_Homo sapiens_hsa053104.18059201
3Oxidative phosphorylation_Homo sapiens_hsa001903.52345546
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.22267571
5Parkinsons disease_Homo sapiens_hsa050122.95871594
6Proteasome_Homo sapiens_hsa030502.77846090
7Allograft rejection_Homo sapiens_hsa053302.51441563
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.42019259
9Autoimmune thyroid disease_Homo sapiens_hsa053202.41305545
10Protein export_Homo sapiens_hsa030602.29868856
11Graft-versus-host disease_Homo sapiens_hsa053322.17862176
12Type I diabetes mellitus_Homo sapiens_hsa049402.15116429
13Huntingtons disease_Homo sapiens_hsa050162.11642473
14Alzheimers disease_Homo sapiens_hsa050101.92073773
15Cardiac muscle contraction_Homo sapiens_hsa042601.91134268
16Linoleic acid metabolism_Homo sapiens_hsa005911.90296731
17Caffeine metabolism_Homo sapiens_hsa002321.78544693
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77532173
19Homologous recombination_Homo sapiens_hsa034401.75440212
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64424785
21RNA degradation_Homo sapiens_hsa030181.64421981
22RNA polymerase_Homo sapiens_hsa030201.62759587
23Nucleotide excision repair_Homo sapiens_hsa034201.60773267
24Basal transcription factors_Homo sapiens_hsa030221.34126592
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24190341
26Fat digestion and absorption_Homo sapiens_hsa049751.20315116
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15962397
28Mismatch repair_Homo sapiens_hsa034301.14493193
29Viral myocarditis_Homo sapiens_hsa054161.11708926
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11273249
31Staphylococcus aureus infection_Homo sapiens_hsa051501.09057667
32Propanoate metabolism_Homo sapiens_hsa006401.08690569
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07060621
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.05291477
35Rheumatoid arthritis_Homo sapiens_hsa053231.03108685
36One carbon pool by folate_Homo sapiens_hsa006700.99214892
37Antigen processing and presentation_Homo sapiens_hsa046120.95238801
38Fanconi anemia pathway_Homo sapiens_hsa034600.94077261
39Pyrimidine metabolism_Homo sapiens_hsa002400.91553321
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90478495
41DNA replication_Homo sapiens_hsa030300.89568107
42Nitrogen metabolism_Homo sapiens_hsa009100.89335920
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87268780
44Peroxisome_Homo sapiens_hsa041460.86385416
45Non-homologous end-joining_Homo sapiens_hsa034500.86073445
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85467236
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84160023
48Ether lipid metabolism_Homo sapiens_hsa005650.83263263
49Sulfur metabolism_Homo sapiens_hsa009200.79804733
50Arachidonic acid metabolism_Homo sapiens_hsa005900.79686804
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77080733
52Primary immunodeficiency_Homo sapiens_hsa053400.76881709
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76121383
54Tryptophan metabolism_Homo sapiens_hsa003800.75493172
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74105018
56Sulfur relay system_Homo sapiens_hsa041220.73140615
57Spliceosome_Homo sapiens_hsa030400.70629516
58Folate biosynthesis_Homo sapiens_hsa007900.69592336
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69152007
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.69088177
61RNA transport_Homo sapiens_hsa030130.66944862
62Base excision repair_Homo sapiens_hsa034100.66828949
63Nicotine addiction_Homo sapiens_hsa050330.66203034
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65583894
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65417585
66Phototransduction_Homo sapiens_hsa047440.64597071
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63698066
68Purine metabolism_Homo sapiens_hsa002300.61837899
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61337473
70Metabolic pathways_Homo sapiens_hsa011000.59373876
71Chemical carcinogenesis_Homo sapiens_hsa052040.56407665
72Steroid biosynthesis_Homo sapiens_hsa001000.54888538
73Systemic lupus erythematosus_Homo sapiens_hsa053220.54301235
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49958351
75Hematopoietic cell lineage_Homo sapiens_hsa046400.48815250
76Vitamin digestion and absorption_Homo sapiens_hsa049770.46326802
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.45804606
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44227443
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43207773
80Mineral absorption_Homo sapiens_hsa049780.42204767
81Butanoate metabolism_Homo sapiens_hsa006500.40556423
82Pyruvate metabolism_Homo sapiens_hsa006200.38745254
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38562997
84Fatty acid biosynthesis_Homo sapiens_hsa000610.36938680
85Regulation of autophagy_Homo sapiens_hsa041400.36393982
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34684714
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33227362
88Glutathione metabolism_Homo sapiens_hsa004800.32312143
89Retinol metabolism_Homo sapiens_hsa008300.32237210
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.25435907
91Epstein-Barr virus infection_Homo sapiens_hsa051690.23265661
92Herpes simplex infection_Homo sapiens_hsa051680.21801718
93Morphine addiction_Homo sapiens_hsa050320.20602289
94Ovarian steroidogenesis_Homo sapiens_hsa049130.20183821
95Leishmaniasis_Homo sapiens_hsa051400.19571366
96Olfactory transduction_Homo sapiens_hsa047400.18350055
97Phagosome_Homo sapiens_hsa041450.17246878
98Collecting duct acid secretion_Homo sapiens_hsa049660.16028320
99Insulin secretion_Homo sapiens_hsa049110.14670868
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12685547

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