RPL36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L36E family of ribosomal proteins. It is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.92486313
2* viral transcription (GO:0019083)8.10505555
3* translational termination (GO:0006415)7.76490071
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.37416462
5ribosomal small subunit biogenesis (GO:0042274)7.29070950
6* translational elongation (GO:0006414)6.78847039
7* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.62454047
8ATP synthesis coupled proton transport (GO:0015986)6.59641741
9energy coupled proton transport, down electrochemical gradient (GO:0015985)6.59641741
10* protein targeting to ER (GO:0045047)6.45401423
11* cotranslational protein targeting to membrane (GO:0006613)6.44416683
12maturation of SSU-rRNA (GO:0030490)6.35932347
13* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.13572656
14* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.13486751
15* protein localization to endoplasmic reticulum (GO:0070972)6.03405625
16* viral life cycle (GO:0019058)6.02173727
17* cellular protein complex disassembly (GO:0043624)5.97955455
18* translational initiation (GO:0006413)5.83475736
19chaperone-mediated protein transport (GO:0072321)5.56332044
20DNA deamination (GO:0045006)5.53638525
21establishment of protein localization to mitochondrial membrane (GO:0090151)5.39891553
22* protein complex disassembly (GO:0043241)5.35186172
23respiratory electron transport chain (GO:0022904)5.19088443
24ribosomal large subunit biogenesis (GO:0042273)5.17802525
25electron transport chain (GO:0022900)5.07332294
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.07067122
27* macromolecular complex disassembly (GO:0032984)4.98768094
28* nuclear-transcribed mRNA catabolic process (GO:0000956)4.50847828
29ribonucleoprotein complex biogenesis (GO:0022613)4.41410372
30regulation of mitochondrial translation (GO:0070129)4.32236754
31* mRNA catabolic process (GO:0006402)4.29820762
32* translation (GO:0006412)4.26954526
33protein complex biogenesis (GO:0070271)4.24351365
34* protein targeting to membrane (GO:0006612)4.24002168
35formation of translation preinitiation complex (GO:0001731)4.16291045
36* RNA catabolic process (GO:0006401)4.07954356
37mitochondrial respiratory chain complex assembly (GO:0033108)4.07592245
38mitochondrial respiratory chain complex I assembly (GO:0032981)4.06660770
39NADH dehydrogenase complex assembly (GO:0010257)4.06660770
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.06660770
41telomere maintenance via semi-conservative replication (GO:0032201)4.02077229
42DNA strand elongation involved in DNA replication (GO:0006271)3.95062431
43DNA strand elongation (GO:0022616)3.76531771
44ATP biosynthetic process (GO:0006754)3.64750479
45protein targeting to mitochondrion (GO:0006626)3.62977953
46inner mitochondrial membrane organization (GO:0007007)3.61527603
47rRNA processing (GO:0006364)3.60126514
48purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.53162757
49purine nucleoside triphosphate biosynthetic process (GO:0009145)3.52315415
50establishment of protein localization to mitochondrion (GO:0072655)3.48393800
51deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.46700798
52rRNA metabolic process (GO:0016072)3.46138242
53DNA unwinding involved in DNA replication (GO:0006268)3.45735979
54telomere maintenance via recombination (GO:0000722)3.45365270
55pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.40862169
56DNA replication initiation (GO:0006270)3.39949606
57oxidative phosphorylation (GO:0006119)3.34612937
58protein localization to mitochondrion (GO:0070585)3.29598015
59ribonucleoside triphosphate biosynthetic process (GO:0009201)3.28423684
60cellular component biogenesis (GO:0044085)3.27345898
61protein neddylation (GO:0045116)3.26423195
62* protein localization to membrane (GO:0072657)3.24895680
63mitotic recombination (GO:0006312)3.22735662
64hydrogen ion transmembrane transport (GO:1902600)3.20967553
65GTP biosynthetic process (GO:0006183)3.16468305
66telomere maintenance via telomere lengthening (GO:0010833)3.15191018
67folic acid-containing compound biosynthetic process (GO:0009396)3.12946979
68ncRNA 3-end processing (GO:0043628)3.10578765
69ribosome biogenesis (GO:0042254)3.09746822
70UTP biosynthetic process (GO:0006228)3.08811075
71pseudouridine synthesis (GO:0001522)3.08800167
72guanosine-containing compound biosynthetic process (GO:1901070)2.99591475
73nucleotide-excision repair, DNA gap filling (GO:0006297)2.99213978
74negative regulation of RNA splicing (GO:0033119)2.98949541
75IMP biosynthetic process (GO:0006188)2.95413434
76spliceosomal snRNP assembly (GO:0000387)2.95289650
77mitochondrial transport (GO:0006839)2.93031122
78negative regulation of ligase activity (GO:0051352)2.91590466
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.91590466
80nucleoside triphosphate biosynthetic process (GO:0009142)2.91106149
817-methylguanosine mRNA capping (GO:0006370)2.91085946
82nucleobase biosynthetic process (GO:0046112)2.87849379
83purine nucleoside monophosphate biosynthetic process (GO:0009127)2.86729350
84purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.86729350
85intracellular protein transmembrane import (GO:0044743)2.85643999
86protein localization to kinetochore (GO:0034501)2.85289314
87RNA capping (GO:0036260)2.85084258
887-methylguanosine RNA capping (GO:0009452)2.85084258
89* establishment of protein localization to membrane (GO:0090150)2.83894451
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82589039
91cytochrome complex assembly (GO:0017004)2.81940966
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.80582974
93aerobic respiration (GO:0009060)2.80323795
94regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80020772
95* protein localization to organelle (GO:0033365)2.78344776
96UTP metabolic process (GO:0046051)2.76653886
97spliceosomal complex assembly (GO:0000245)2.76492917
98pyrimidine nucleotide catabolic process (GO:0006244)2.75568239
99establishment of integrated proviral latency (GO:0075713)2.74133367
100* establishment of protein localization to organelle (GO:0072594)2.67390466
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66405812
102DNA replication checkpoint (GO:0000076)2.66016263
103T cell apoptotic process (GO:0070231)2.63649146
104transcription-coupled nucleotide-excision repair (GO:0006283)2.63304919
105mitotic nuclear envelope disassembly (GO:0007077)2.62309741
106* protein targeting (GO:0006605)2.61674326
107IMP metabolic process (GO:0046040)2.61286648
108chromatin remodeling at centromere (GO:0031055)2.58342192
109proteasome assembly (GO:0043248)2.56270982
110purine nucleobase biosynthetic process (GO:0009113)2.56175489
111regulation of protein heterodimerization activity (GO:0043497)2.54075168
112CENP-A containing nucleosome assembly (GO:0034080)2.53045501
113response to interferon-beta (GO:0035456)2.52815143
114kinetochore organization (GO:0051383)2.52484423
115ncRNA processing (GO:0034470)2.52348369
116DNA replication-dependent nucleosome assembly (GO:0006335)2.52337645
117DNA replication-dependent nucleosome organization (GO:0034723)2.52337645
118nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.51736996
119protein localization to chromosome, centromeric region (GO:0071459)2.51401008
120rRNA modification (GO:0000154)2.50359591
121termination of RNA polymerase II transcription (GO:0006369)2.50035349
122negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.49137789
123pteridine-containing compound biosynthetic process (GO:0042559)2.48381022
124RNA splicing, via transesterification reactions (GO:0000375)2.47299562
125RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.47208393
126mRNA splicing, via spliceosome (GO:0000398)2.47208393
127kinetochore assembly (GO:0051382)2.43823162
128* gene expression (GO:0010467)2.42102401
129termination of RNA polymerase III transcription (GO:0006386)2.40527530
130transcription elongation from RNA polymerase III promoter (GO:0006385)2.40527530
131telomere maintenance (GO:0000723)2.40052576
132ribosome assembly (GO:0042255)2.39857818
133telomere organization (GO:0032200)2.39227890
134regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.38881929
135ncRNA metabolic process (GO:0034660)2.35488992
136membrane disassembly (GO:0030397)2.35298329
137nuclear envelope disassembly (GO:0051081)2.35298329
138negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.34938157
139DNA replication-independent nucleosome organization (GO:0034724)2.34108101
140DNA replication-independent nucleosome assembly (GO:0006336)2.34108101
141ribonucleoprotein complex assembly (GO:0022618)2.33259707
142histone mRNA metabolic process (GO:0008334)2.32361126
143nucleoside salvage (GO:0043174)2.31505927
144DNA duplex unwinding (GO:0032508)2.30217537
145base-excision repair (GO:0006284)2.29638583
146lymphocyte apoptotic process (GO:0070227)2.27777162
147DNA geometric change (GO:0032392)2.27624204
148viral mRNA export from host cell nucleus (GO:0046784)2.27169224

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.27436321
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.14943585
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04026303
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99957427
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.99318640
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69865768
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.67127913
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.65510696
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.64337972
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62958631
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55797664
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.53580523
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47642938
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.45802273
15* XRN2_22483619_ChIP-Seq_HELA_Human2.42297870
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37604565
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32391283
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26881246
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23754676
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12621552
21MYC_22102868_ChIP-Seq_BL_Human2.11677038
22* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.11220440
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10835902
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10446214
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.03346691
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02399368
27* VDR_23849224_ChIP-Seq_CD4+_Human2.00889175
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98095686
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86673253
30DCP1A_22483619_ChIP-Seq_HELA_Human1.80640012
31* VDR_21846776_ChIP-Seq_THP-1_Human1.78209468
32FOXP3_21729870_ChIP-Seq_TREG_Human1.78183970
33* TTF2_22483619_ChIP-Seq_HELA_Human1.75422085
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.72886706
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67709038
36* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67574015
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63053310
38CIITA_25753668_ChIP-Seq_RAJI_Human1.61838742
39GABP_19822575_ChIP-Seq_HepG2_Human1.60333735
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59990677
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56021784
42* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55987187
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55710937
44MYC_18940864_ChIP-ChIP_HL60_Human1.52388588
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.47429845
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46319924
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46149253
48* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44872864
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.43928598
50* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42525093
51ELK1_19687146_ChIP-ChIP_HELA_Human1.41955374
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39504758
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38513664
54* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38335465
55* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35147753
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34557065
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33604305
58* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33458992
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32253500
60* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32137810
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32045565
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29718701
63SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27807453
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.26145870
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24032375
66SPI1_23547873_ChIP-Seq_NB4_Human1.23283523
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23080220
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21784480
69TP63_17297297_ChIP-ChIP_HaCaT_Human1.21773305
70KDM5A_27292631_Chip-Seq_BREAST_Human1.20178656
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18856466
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15910337
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15713465
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15529744
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15327839
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13622256
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.13060637
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12414133
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12256310
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12062348
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11875428
82SCL_19346495_ChIP-Seq_HPC-7_Human1.11519743
83* FOXP1_21924763_ChIP-Seq_HESCs_Human1.10988453
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10238180
85* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09376062
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08885736
87IRF8_22096565_ChIP-ChIP_GC-B_Human1.08179396
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.06811360
89MAF_26560356_Chip-Seq_TH1_Human1.06297481
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06167561
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05409785
92AR_21909140_ChIP-Seq_LNCAP_Human1.05126979
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04768320
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04518049
95* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04151240
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03633218
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02947838
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01743684
99* MAF_26560356_Chip-Seq_TH2_Human1.01615053
100TFEB_21752829_ChIP-Seq_HELA_Human1.00499904
101* UTX_26944678_Chip-Seq_JUKART_Human1.00419392
102PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99841591
103STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98317205
104* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97762568
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96615061
106TP63_19390658_ChIP-ChIP_HaCaT_Human0.95411813
107SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94809783
108* VDR_24763502_ChIP-Seq_THP-1_Human0.94516657
109ELK1_22589737_ChIP-Seq_MCF10A_Human0.93356081
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93190199
111CTCF_26484167_Chip-Seq_Bcells_Mouse0.92876673
112ZNF263_19887448_ChIP-Seq_K562_Human0.92715734
113OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92401029
114RUNX1_22412390_ChIP-Seq_EML_Mouse0.92137645
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90271222
116MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90059823
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90059720
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.87857292
119SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87635441
120* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87107101
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86985066
122YY1_22570637_ChIP-Seq_MALME-3M_Human0.84281305
123ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82154760
124SOX2_16153702_ChIP-ChIP_HESCs_Human0.81430224
125DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79076583
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.78680537
127ELF1_20517297_ChIP-Seq_JURKAT_Human0.78538619
128EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78436620

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.35159425
2MP0006292_abnormal_olfactory_placode3.70068770
3MP0004957_abnormal_blastocyst_morpholog3.44448820
4MP0002396_abnormal_hematopoietic_system2.95908073
5MP0003077_abnormal_cell_cycle2.95007176
6MP0003111_abnormal_nucleus_morphology2.93980697
7MP0010094_abnormal_chromosome_stability2.88993963
8MP0003136_yellow_coat_color2.83104010
9MP0009379_abnormal_foot_pigmentation2.79849247
10MP0000566_synostosis2.55906874
11MP0002938_white_spotting2.53026850
12MP0010352_gastrointestinal_tract_polyps2.42343350
13MP0008057_abnormal_DNA_replication2.24482952
14MP0008007_abnormal_cellular_replicative2.15466832
15MP0008058_abnormal_DNA_repair2.12510771
16MP0000490_abnormal_crypts_of2.09081443
17MP0003763_abnormal_thymus_physiology2.01022565
18MP0001835_abnormal_antigen_presentation1.93998242
19MP0009333_abnormal_splenocyte_physiolog1.92053506
20MP0004808_abnormal_hematopoietic_stem1.91106547
21MP0001545_abnormal_hematopoietic_system1.80120680
22MP0005397_hematopoietic_system_phenotyp1.80120680
23MP0000685_abnormal_immune_system1.79189298
24MP0008995_early_reproductive_senescence1.77612724
25MP0002277_abnormal_respiratory_mucosa1.76956736
26MP0008932_abnormal_embryonic_tissue1.72981863
27MP0001346_abnormal_lacrimal_gland1.70961018
28MP0002163_abnormal_gland_morphology1.68731721
29MP0000350_abnormal_cell_proliferation1.63197510
30MP0002398_abnormal_bone_marrow1.61505701
31MP0000049_abnormal_middle_ear1.60687937
32MP0008789_abnormal_olfactory_epithelium1.58859479
33MP0002653_abnormal_ependyma_morphology1.58632174
34MP0000372_irregular_coat_pigmentation1.56758791
35MP0002722_abnormal_immune_system1.49955592
36MP0001730_embryonic_growth_arrest1.48690605
37MP0002019_abnormal_tumor_incidence1.47776165
38MP0002234_abnormal_pharynx_morphology1.47666426
39MP0003786_premature_aging1.47581901
40MP0006054_spinal_hemorrhage1.46983282
41MP0000689_abnormal_spleen_morphology1.42728812
42MP0003436_decreased_susceptibility_to1.42486614
43MP0001800_abnormal_humoral_immune1.42315198
44MP0000703_abnormal_thymus_morphology1.41902842
45MP0003283_abnormal_digestive_organ1.38694778
46MP0000858_altered_metastatic_potential1.38389727
47MP0000313_abnormal_cell_death1.37968504
48MP0003938_abnormal_ear_development1.37798083
49MP0009785_altered_susceptibility_to1.37308898
50MP0002166_altered_tumor_susceptibility1.36250958
51MP0002132_abnormal_respiratory_system1.36155507
52MP0003567_abnormal_fetal_cardiomyocyte1.36109054
53MP0000537_abnormal_urethra_morphology1.35866736
54MP0001853_heart_inflammation1.34687025
55MP0002160_abnormal_reproductive_system1.33712522
56MP0005671_abnormal_response_to1.33056480
57MP0003186_abnormal_redox_activity1.32800473
58MP0002429_abnormal_blood_cell1.31590391
59MP0006035_abnormal_mitochondrial_morpho1.30697600
60MP0010155_abnormal_intestine_physiology1.29618796
61MP0002452_abnormal_antigen_presenting1.28970378
62MP0002420_abnormal_adaptive_immunity1.28588788
63MP0005174_abnormal_tail_pigmentation1.28032498
64MP0005025_abnormal_response_to1.26957672
65MP0001819_abnormal_immune_cell1.26639060
66MP0000716_abnormal_immune_system1.26378744
67MP0002405_respiratory_system_inflammati1.23731201
68MP0000631_abnormal_neuroendocrine_gland1.23495313
69MP0003806_abnormal_nucleotide_metabolis1.22236245
70MP0005499_abnormal_olfactory_system1.21737561
71MP0005394_taste/olfaction_phenotype1.21737561
72MP0010307_abnormal_tumor_latency1.21618809
73MP0009278_abnormal_bone_marrow1.20992780
74MP0002210_abnormal_sex_determination1.18831966
75MP0002249_abnormal_larynx_morphology1.17318451
76MP0002723_abnormal_immune_serum1.17200670
77MP0002080_prenatal_lethality1.15120179
78MP0001697_abnormal_embryo_size1.14620475
79MP0002006_tumorigenesis1.13738948
80MP0005000_abnormal_immune_tolerance1.12062655
81MP0003123_paternal_imprinting1.10399694
82MP0001873_stomach_inflammation1.09381826
83MP0005380_embryogenesis_phenotype1.09019892
84MP0001672_abnormal_embryogenesis/_devel1.09019892
85MP0002697_abnormal_eye_size1.08845807
86MP0004142_abnormal_muscle_tone1.08494240
87MP0002148_abnormal_hypersensitivity_rea1.08074535
88MP0003941_abnormal_skin_development1.07202123
89MP0003011_delayed_dark_adaptation1.05230278
90MP0006072_abnormal_retinal_apoptosis1.05114079
91MP0005023_abnormal_wound_healing1.04881804
92MP0005075_abnormal_melanosome_morpholog1.04824961
93MP0001286_abnormal_eye_development1.04390446
94MP0003984_embryonic_growth_retardation1.03140829
95MP0001529_abnormal_vocalization1.02757129
96MP0002086_abnormal_extraembryonic_tissu1.01810609
97MP0005408_hypopigmentation1.01373139
98MP0002088_abnormal_embryonic_growth/wei1.01130092
99MP0005464_abnormal_platelet_physiology1.00722597
100MP0001905_abnormal_dopamine_level0.98290615
101MP0010030_abnormal_orbit_morphology0.97759219
102MP0000465_gastrointestinal_hemorrhage0.93482472
103MP0003866_abnormal_defecation0.93481380
104MP0004197_abnormal_fetal_growth/weight/0.92877875
105MP0001790_abnormal_immune_system0.92727743
106MP0005387_immune_system_phenotype0.92727743
107MP0005389_reproductive_system_phenotype0.92595858
108MP0009250_abnormal_appendicular_skeleto0.92157821
109MP0002085_abnormal_embryonic_tissue0.91340943
110MP0000762_abnormal_tongue_morphology0.88298554
111MP0000477_abnormal_intestine_morphology0.87747368
112MP0002095_abnormal_skin_pigmentation0.86879596
113MP0003937_abnormal_limbs/digits/tail_de0.86597689
114MP0001145_abnormal_male_reproductive0.86156009
115MP0001764_abnormal_homeostasis0.85294091
116MP0002084_abnormal_developmental_patter0.82274900
117MP0001293_anophthalmia0.81876047
118MP0003566_abnormal_cell_adhesion0.81055790
119MP0001845_abnormal_inflammatory_respons0.80845478
120MP0002877_abnormal_melanocyte_morpholog0.80304406
121MP0000653_abnormal_sex_gland0.79622467
122MP0005076_abnormal_cell_differentiation0.79399402
123MP0001919_abnormal_reproductive_system0.79164537
124MP0001881_abnormal_mammary_gland0.78726342
125MP0001929_abnormal_gametogenesis0.78465467
126MP0005084_abnormal_gallbladder_morpholo0.78424802
127MP0000026_abnormal_inner_ear0.76448581
128MP0001485_abnormal_pinna_reflex0.76389601
129MP0000358_abnormal_cell_content/0.76141133
130MP0002419_abnormal_innate_immunity0.75752039
131MP0000750_abnormal_muscle_regeneration0.74870081
132MP0005501_abnormal_skin_physiology0.74171158
133MP0003315_abnormal_perineum_morphology0.73588577
134MP0002638_abnormal_pupillary_reflex0.73316866
135MP0006036_abnormal_mitochondrial_physio0.72476567
136MP0002233_abnormal_nose_morphology0.72256088
137MP0004742_abnormal_vestibular_system0.71991684
138MP0003448_altered_tumor_morphology0.70158202
139MP0003942_abnormal_urinary_system0.69665582
140MP0005377_hearing/vestibular/ear_phenot0.68904425
141MP0003878_abnormal_ear_physiology0.68904425
142MP0009697_abnormal_copulation0.68896689
143MP0005379_endocrine/exocrine_gland_phen0.68259163
144MP0003119_abnormal_digestive_system0.68187975
145MP0003705_abnormal_hypodermis_morpholog0.67007493
146MP0002282_abnormal_trachea_morphology0.66248157
147MP0002822_catalepsy0.65279367
148MP0000678_abnormal_parathyroid_gland0.64982719
149MP0004133_heterotaxia0.64602555
150MP0004947_skin_inflammation0.63285714
151MP0001188_hyperpigmentation0.63061068
152MP0002092_abnormal_eye_morphology0.61187882
153MP0009931_abnormal_skin_appearance0.61128524
154MP0003718_maternal_effect0.60361888
155MP0001849_ear_inflammation0.58959384
156MP0001915_intracranial_hemorrhage0.57345674
157MP0009053_abnormal_anal_canal0.57050449
158MP0002111_abnormal_tail_morphology0.56808360
159MP0001119_abnormal_female_reproductive0.56709286

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.60230722
2Reticulocytopenia (HP:0001896)7.41744503
3Abnormal number of erythroid precursors (HP:0012131)7.12961025
4Acute necrotizing encephalopathy (HP:0006965)5.56907832
5Abnormal mitochondria in muscle tissue (HP:0008316)5.23718183
6Macrocytic anemia (HP:0001972)4.91996813
7Pallor (HP:0000980)4.87495455
8Acute encephalopathy (HP:0006846)4.82050938
9Increased CSF lactate (HP:0002490)4.48359643
10Thrombocytosis (HP:0001894)4.47361289
11Progressive macrocephaly (HP:0004481)4.40755879
12Renal Fanconi syndrome (HP:0001994)4.32107294
13Aplastic anemia (HP:0001915)4.07865315
14Colon cancer (HP:0003003)3.54755218
15Cerebral edema (HP:0002181)3.52699075
16Oral leukoplakia (HP:0002745)3.42453068
17Aplasia/Hypoplasia of the sacrum (HP:0008517)3.41624042
183-Methylglutaconic aciduria (HP:0003535)3.37993742
19Multiple enchondromatosis (HP:0005701)3.34377188
20Abnormality of reticulocytes (HP:0004312)3.05237957
2111 pairs of ribs (HP:0000878)3.04688471
22Exercise intolerance (HP:0003546)3.01827728
23Selective tooth agenesis (HP:0001592)2.96731306
24Lactic acidosis (HP:0003128)2.92996537
25Partial duplication of thumb phalanx (HP:0009944)2.79986643
26Absent thumb (HP:0009777)2.79659640
27Respiratory failure (HP:0002878)2.77853097
28Partial duplication of the phalanx of hand (HP:0009999)2.71642978
29IgM deficiency (HP:0002850)2.69573201
30Trismus (HP:0000211)2.68187499
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63733685
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63733685
33Microvesicular hepatic steatosis (HP:0001414)2.61073275
34Abnormality of renal resorption (HP:0011038)2.60746020
35Elevated erythrocyte sedimentation rate (HP:0003565)2.53076702
36Petechiae (HP:0000967)2.49084966
37Congenital, generalized hypertrichosis (HP:0004540)2.44967269
38Leukodystrophy (HP:0002415)2.44182619
39Rough bone trabeculation (HP:0100670)2.40733296
40Optic disc pallor (HP:0000543)2.40048728
41Birth length less than 3rd percentile (HP:0003561)2.36856769
42Microretrognathia (HP:0000308)2.36373245
43Missing ribs (HP:0000921)2.35676336
44Abnormal hemoglobin (HP:0011902)2.34279225
45Myelodysplasia (HP:0002863)2.32304774
46Abnormality of T cell physiology (HP:0011840)2.21804153
47Septo-optic dysplasia (HP:0100842)2.15948025
48Degeneration of anterior horn cells (HP:0002398)2.15249297
49Abnormality of the anterior horn cell (HP:0006802)2.15249297
50Glycosuria (HP:0003076)2.14591780
51Abnormality of urine glucose concentration (HP:0011016)2.14591780
52Depressed nasal ridge (HP:0000457)2.13621045
53Testicular atrophy (HP:0000029)2.11498498
54Poikiloderma (HP:0001029)2.11449518
55Premature graying of hair (HP:0002216)2.08622035
56Hyperphosphaturia (HP:0003109)2.07022438
57Exertional dyspnea (HP:0002875)2.05433770
58Carpal bone hypoplasia (HP:0001498)2.05153359
59Abnormality of the parietal bone (HP:0002696)2.02509530
60Lymphoma (HP:0002665)2.01801993
61Chromsome breakage (HP:0040012)2.01541610
62Nasolacrimal duct obstruction (HP:0000579)1.99655255
63Type I transferrin isoform profile (HP:0003642)1.99446085
64Lethargy (HP:0001254)1.97435934
65Abnormality of T cells (HP:0002843)1.97228332
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96882005
67Pancytopenia (HP:0001876)1.96579102
68Duplication of thumb phalanx (HP:0009942)1.95783935
69Rib fusion (HP:0000902)1.95648390
70Neoplasm of the pancreas (HP:0002894)1.95043949
71Abnormal number of incisors (HP:0011064)1.94961832
72Asplenia (HP:0001746)1.92238576
73Breast hypoplasia (HP:0003187)1.92038373
74Basal cell carcinoma (HP:0002671)1.91293697
75Abnormality of the heme biosynthetic pathway (HP:0010472)1.90009262
76Stenosis of the external auditory canal (HP:0000402)1.89843154
77Acute lymphatic leukemia (HP:0006721)1.89684798
78Muscle fiber atrophy (HP:0100295)1.89221776
79Amaurosis fugax (HP:0100576)1.88927859
80Cellular immunodeficiency (HP:0005374)1.87996742
81Hepatocellular necrosis (HP:0001404)1.86206225
82Increased hepatocellular lipid droplets (HP:0006565)1.84593000
83Patellar aplasia (HP:0006443)1.82864129
84Tracheoesophageal fistula (HP:0002575)1.82707473
85Hypoplasia of the pons (HP:0012110)1.82445524
86Cleft eyelid (HP:0000625)1.82093002
87Recurrent bronchitis (HP:0002837)1.82063647
88Hypoplasia of the radius (HP:0002984)1.82057691
89Generalized aminoaciduria (HP:0002909)1.81958935
90Migraine (HP:0002076)1.81781561
91Increased intramyocellular lipid droplets (HP:0012240)1.78636370
92Hepatic necrosis (HP:0002605)1.78421034
93Bone marrow hypocellularity (HP:0005528)1.78205064
94Concave nail (HP:0001598)1.78117613
95Thick lower lip vermilion (HP:0000179)1.77171096
96Progressive muscle weakness (HP:0003323)1.77034760
97Meckel diverticulum (HP:0002245)1.76827278
98Sparse eyelashes (HP:0000653)1.76093789
99Aplasia/Hypoplasia of the spleen (HP:0010451)1.75828712
100Aplasia/Hypoplasia of the patella (HP:0006498)1.75325528
101Prolonged bleeding time (HP:0003010)1.73749965
102Triphalangeal thumb (HP:0001199)1.73426925
103Abnormality of the preputium (HP:0100587)1.73258421
104Optic nerve coloboma (HP:0000588)1.72747501
105Horseshoe kidney (HP:0000085)1.72669543
106Emotional lability (HP:0000712)1.72288143
107Abnormality of the pons (HP:0007361)1.71648064
108Abnormality of the ileum (HP:0001549)1.71475207
109Chronic otitis media (HP:0000389)1.70775152
110Abnormal urine phosphate concentration (HP:0012599)1.70275332
111Rectal prolapse (HP:0002035)1.69991190
112Maternal diabetes (HP:0009800)1.69776074
113Cellulitis (HP:0100658)1.69664216
114Premature ovarian failure (HP:0008209)1.69066348
115Agnosia (HP:0010524)1.68550847
116Chromosomal breakage induced by crosslinking agents (HP:0003221)1.67545826
117Sclerocornea (HP:0000647)1.67404875
118Poor head control (HP:0002421)1.66921108
119Recurrent viral infections (HP:0004429)1.66866025
120Methylmalonic aciduria (HP:0012120)1.66503599
121Recurrent abscess formation (HP:0002722)1.66380935
122Abnormal protein glycosylation (HP:0012346)1.66204981
123Abnormal glycosylation (HP:0012345)1.66204981
124Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66204981
125Abnormal protein N-linked glycosylation (HP:0012347)1.66204981
126Increased serum lactate (HP:0002151)1.65969356
127Medulloblastoma (HP:0002885)1.65715668
128Nasal polyposis (HP:0100582)1.64464470
129Mitochondrial inheritance (HP:0001427)1.63955808
130Lipid accumulation in hepatocytes (HP:0006561)1.63599208
131Abnormal trabecular bone morphology (HP:0100671)1.63471000
132Reduced antithrombin III activity (HP:0001976)1.63276371
133Pustule (HP:0200039)1.63169908
134Panhypogammaglobulinemia (HP:0003139)1.62451347
135Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.61891783
136Abnormality of dicarboxylic acid metabolism (HP:0010995)1.61034518
137Dicarboxylic aciduria (HP:0003215)1.61034518
138Hyperglycinemia (HP:0002154)1.60844242
139Abnormality of chromosome stability (HP:0003220)1.60768068
140Renal tubular dysfunction (HP:0000124)1.60760780
141Absent septum pellucidum (HP:0001331)1.60741145
142X-linked dominant inheritance (HP:0001423)1.60154575
143Atresia of the external auditory canal (HP:0000413)1.59924500
144Increased muscle lipid content (HP:0009058)1.59550484
145Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.59035266
146Abnormality of cells of the lymphoid lineage (HP:0012140)1.58575574
147Abnormal delayed hypersensitivity skin test (HP:0002963)1.58211865
148CNS demyelination (HP:0007305)1.57083238
149Myositis (HP:0100614)1.56720901
150Pulmonary fibrosis (HP:0002206)1.56301908
151Respiratory difficulties (HP:0002880)1.56216733
152Ependymoma (HP:0002888)1.55574164
153Abnormality of the lacrimal duct (HP:0011481)1.55166737
154Glossoptosis (HP:0000162)1.54908758
155Bilateral microphthalmos (HP:0007633)1.54499027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.69549481
2NME24.26796786
3BUB12.91316320
4WEE12.72561842
5EEF2K2.69965643
6NME12.66396419
7MAP4K12.41487364
8RPS6KB22.36724540
9TLK12.31911407
10PIM22.31648542
11MAP3K102.17979555
12LRRK22.09736350
13PKN21.99889673
14TAF11.97246426
15CDC71.96471236
16FLT31.84190984
17NEK21.74097729
18VRK11.68463297
19RPS6KA41.67456631
20SRPK11.62214846
21TESK21.61132830
22EIF2AK11.58743882
23PASK1.54921542
24TGFBR11.54907782
25CDK71.52611888
26DYRK31.48727044
27SMG11.46516942
28STK161.45142615
29PBK1.42972268
30AURKB1.39211122
31NUAK11.36951203
32EPHB21.34694006
33PIM11.33296010
34STK101.31673585
35KDR1.30825395
36DYRK21.27680559
37MAP3K81.27454131
38ARAF1.27446383
39BTK1.27273494
40SCYL21.26780623
41CDK41.26614524
42PAK41.25657009
43TYK21.24466250
44ERN11.22297723
45ILK1.21080993
46PLK11.19791894
47TRIB31.18120739
48ATR1.13514293
49MAPKAPK31.10230420
50MAP3K111.10070648
51TSSK61.08380936
52MAP2K31.06894134
53NEK11.06270990
54ACVR1B1.06256676
55ZAP701.06207476
56BLK1.05930069
57TEC1.05687570
58BRSK21.05213493
59BCKDK1.04571081
60TTK1.03332881
61IKBKB1.01154629
62STK41.00579215
63EIF2AK30.97003575
64PLK40.95088564
65KIT0.93818095
66MAPK150.93434785
67JAK30.92426913
68TBK10.91943348
69TESK10.89879806
70BRSK10.88121479
71PLK30.87762522
72EPHA20.86634223
73MAP2K20.77761168
74CSF1R0.77729107
75MKNK10.77551566
76AURKA0.77260645
77CDK120.77008127
78GRK60.76173616
79IKBKE0.74208990
80ZAK0.72964396
81DAPK30.69595048
82PDK20.67865382
83CSNK2A20.67401723
84RPS6KA50.67192133
85TXK0.67055312
86RPS6KA60.65919371
87RPS6KC10.64999275
88RPS6KL10.64999275
89CCNB10.63409937
90CHEK20.61946700
91IRAK30.61897084
92CSNK2A10.61357166
93IRAK40.61000616
94CHEK10.60894515
95MST40.60783501
96CDK80.58455251
97CDK60.57743473
98PAK10.57397927
99SYK0.56482953
100CHUK0.55131250
101MAP3K30.53774902
102MYLK0.52304976
103CDK20.51419383
104CLK10.49309752
105STK240.47968566
106MAPKAPK50.46857115
107LYN0.46856148
108PRKCI0.46818568
109MAP3K120.45945571
110MUSK0.45504559
111CDK190.45180296
112LCK0.45178305
113ALK0.44897647
114ABL20.44277624
115ATM0.42170882
116AKT20.42052979
117MATK0.41813021
118BRAF0.41691930
119WNK40.40367193
120LIMK10.37601253
121CSNK1E0.36770330
122TAOK20.32598056
123GRK10.32188431
124CDK10.28363254
125CSNK1G30.27745494
126CDK90.25816345
127INSRR0.25278996
128EIF2AK20.24481335
129BMPR1B0.24439113
130CDK11A0.23624084
131CDK30.23356232
132IRAK20.21011541
133DAPK10.20133778
134PRKCD0.18551004
135PNCK0.16110743
136CSNK1A10.15925006

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030106.47669394
2DNA replication_Homo sapiens_hsa030304.34038597
3Mismatch repair_Homo sapiens_hsa034303.57912703
4Spliceosome_Homo sapiens_hsa030402.90141569
5Base excision repair_Homo sapiens_hsa034102.76996119
6RNA polymerase_Homo sapiens_hsa030202.73323522
7Homologous recombination_Homo sapiens_hsa034402.69355236
8Proteasome_Homo sapiens_hsa030502.64623782
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.56454344
10Nucleotide excision repair_Homo sapiens_hsa034202.35562229
11Pyrimidine metabolism_Homo sapiens_hsa002402.33150257
12One carbon pool by folate_Homo sapiens_hsa006702.20476658
13RNA transport_Homo sapiens_hsa030132.07791095
14Cardiac muscle contraction_Homo sapiens_hsa042601.93937344
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77131984
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67362149
17Cell cycle_Homo sapiens_hsa041101.65040738
18Fanconi anemia pathway_Homo sapiens_hsa034601.55757001
19RNA degradation_Homo sapiens_hsa030181.53581666
20Non-homologous end-joining_Homo sapiens_hsa034501.50640642
21Primary immunodeficiency_Homo sapiens_hsa053401.34198199
22p53 signaling pathway_Homo sapiens_hsa041151.34175479
23Sulfur relay system_Homo sapiens_hsa041221.30838332
24Systemic lupus erythematosus_Homo sapiens_hsa053221.30587324
25Antigen processing and presentation_Homo sapiens_hsa046121.28074110
26Parkinsons disease_Homo sapiens_hsa050121.17799388
27Herpes simplex infection_Homo sapiens_hsa051681.11937969
28Pentose phosphate pathway_Homo sapiens_hsa000301.05993159
29Basal transcription factors_Homo sapiens_hsa030221.05740428
30Protein export_Homo sapiens_hsa030601.04909831
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02263223
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00998833
33Purine metabolism_Homo sapiens_hsa002301.00726362
34Epstein-Barr virus infection_Homo sapiens_hsa051690.99561409
35Huntingtons disease_Homo sapiens_hsa050160.98276194
36mRNA surveillance pathway_Homo sapiens_hsa030150.98129415
37Oxidative phosphorylation_Homo sapiens_hsa001900.97400671
38Drug metabolism - other enzymes_Homo sapiens_hsa009830.95649663
39Folate biosynthesis_Homo sapiens_hsa007900.91091075
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87802036
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85741816
42Legionellosis_Homo sapiens_hsa051340.82126355
43Viral carcinogenesis_Homo sapiens_hsa052030.81667825
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79059419
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77634421
46Measles_Homo sapiens_hsa051620.76998441
47Pyruvate metabolism_Homo sapiens_hsa006200.76626153
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.73938491
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.73405104
50HTLV-I infection_Homo sapiens_hsa051660.72833793
51Apoptosis_Homo sapiens_hsa042100.71759203
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.71642825
53Acute myeloid leukemia_Homo sapiens_hsa052210.69614510
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68600460
55Biosynthesis of amino acids_Homo sapiens_hsa012300.68272456
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67874118
57Hematopoietic cell lineage_Homo sapiens_hsa046400.67765031
58Basal cell carcinoma_Homo sapiens_hsa052170.66394801
59Leishmaniasis_Homo sapiens_hsa051400.66319715
60Thyroid cancer_Homo sapiens_hsa052160.64852887
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61341038
62Fatty acid elongation_Homo sapiens_hsa000620.59841948
63Small cell lung cancer_Homo sapiens_hsa052220.59657736
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57644907
65Selenocompound metabolism_Homo sapiens_hsa004500.57322600
66Galactose metabolism_Homo sapiens_hsa000520.56510100
67N-Glycan biosynthesis_Homo sapiens_hsa005100.55654743
68Glutathione metabolism_Homo sapiens_hsa004800.55591049
69Alzheimers disease_Homo sapiens_hsa050100.53100022
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.51567780
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50995730
72Chronic myeloid leukemia_Homo sapiens_hsa052200.50951670
73Notch signaling pathway_Homo sapiens_hsa043300.50592017
74Fructose and mannose metabolism_Homo sapiens_hsa000510.49670126
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.48299688
76Shigellosis_Homo sapiens_hsa051310.48203135
77Vitamin digestion and absorption_Homo sapiens_hsa049770.47664579
78Hepatitis B_Homo sapiens_hsa051610.47457692
79B cell receptor signaling pathway_Homo sapiens_hsa046620.47067056
80Bladder cancer_Homo sapiens_hsa052190.46534010
81Carbon metabolism_Homo sapiens_hsa012000.45648704
82Influenza A_Homo sapiens_hsa051640.44843516
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.44029921
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43406361
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42513394
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41317963
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40418480
88HIF-1 signaling pathway_Homo sapiens_hsa040660.38736769
89Allograft rejection_Homo sapiens_hsa053300.38710576
90Sulfur metabolism_Homo sapiens_hsa009200.38592044
91Collecting duct acid secretion_Homo sapiens_hsa049660.38319352
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37718727
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37149914
94Tyrosine metabolism_Homo sapiens_hsa003500.36234490
95Peroxisome_Homo sapiens_hsa041460.35890993
96Hedgehog signaling pathway_Homo sapiens_hsa043400.34247054
97Other glycan degradation_Homo sapiens_hsa005110.33144329
98Viral myocarditis_Homo sapiens_hsa054160.32666331
99Toxoplasmosis_Homo sapiens_hsa051450.32342159
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31851100
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31084196
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30945011
103Asthma_Homo sapiens_hsa053100.29123163
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28104036
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27901891
106MicroRNAs in cancer_Homo sapiens_hsa052060.27714138
107Alcoholism_Homo sapiens_hsa050340.27697574
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27399010
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.27337139
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.26719708
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26573536
112Graft-versus-host disease_Homo sapiens_hsa053320.25649077
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25171489
114Propanoate metabolism_Homo sapiens_hsa006400.24912975
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24609578
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23363423
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22721730
118Metabolic pathways_Homo sapiens_hsa011000.21653401
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21170321
120Pathways in cancer_Homo sapiens_hsa052000.20075489
121Chemical carcinogenesis_Homo sapiens_hsa052040.19539197
122Arginine and proline metabolism_Homo sapiens_hsa003300.19246842
123Pertussis_Homo sapiens_hsa051330.19133299
124Fat digestion and absorption_Homo sapiens_hsa049750.15773790
125Phenylalanine metabolism_Homo sapiens_hsa003600.15032650
126Phototransduction_Homo sapiens_hsa047440.14711205
127Linoleic acid metabolism_Homo sapiens_hsa005910.12739431
128Arachidonic acid metabolism_Homo sapiens_hsa005900.11923993
129Vitamin B6 metabolism_Homo sapiens_hsa007500.11380281
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.11291200
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10879693
132Wnt signaling pathway_Homo sapiens_hsa043100.08927093
133Oocyte meiosis_Homo sapiens_hsa041140.08041747
134Nitrogen metabolism_Homo sapiens_hsa009100.07421195
135Butanoate metabolism_Homo sapiens_hsa006500.07411116
136Regulation of autophagy_Homo sapiens_hsa041400.06406075
137Caffeine metabolism_Homo sapiens_hsa002320.06190770
138Tryptophan metabolism_Homo sapiens_hsa003800.04606968
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.03621588
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.03144407

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