ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* viral transcription (GO:0019083)	9.72466365
2	ribosomal small subunit assembly (GO:0000028)	9.39307494
3	* translational termination (GO:0006415)	9.36798994
4	ribosomal small subunit biogenesis (GO:0042274)	8.82080966
5	* translational elongation (GO:0006414)	8.00832976
6	* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.89961388
7	* cotranslational protein targeting to membrane (GO:0006613)	7.74280020
8	* protein targeting to ER (GO:0045047)	7.73645271
9	* establishment of protein localization to endoplasmic reticulum (GO:0072599)	7.39867436
10	maturation of SSU-rRNA (GO:0030490)	7.39360108
11	* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	7.31711658
12	* cellular protein complex disassembly (GO:0043624)	7.25024122
13	* protein localization to endoplasmic reticulum (GO:0070972)	7.24793249
14	* viral life cycle (GO:0019058)	7.21540065
15	* translational initiation (GO:0006413)	6.93291733
16	ribosomal large subunit biogenesis (GO:0042273)	6.62419654
17	* protein complex disassembly (GO:0043241)	6.34054660
18	* macromolecular complex disassembly (GO:0032984)	5.92660394
19	* nuclear-transcribed mRNA catabolic process (GO:0000956)	5.26028327
20	* protein targeting to membrane (GO:0006612)	5.12831674
21	ribonucleoprotein complex biogenesis (GO:0022613)	5.08196287
22	* translation (GO:0006412)	5.00198575
23	chaperone-mediated protein transport (GO:0072321)	4.99771112
24	* mRNA catabolic process (GO:0006402)	4.98996649
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.73614714
26	* RNA catabolic process (GO:0006401)	4.67124003
27	respiratory electron transport chain (GO:0022904)	4.54515479
28	electron transport chain (GO:0022900)	4.43169578
29	DNA deamination (GO:0045006)	4.42815728
30	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.38751197
31	formation of translation preinitiation complex (GO:0001731)	4.37559132
32	rRNA processing (GO:0006364)	4.07371483
33	rRNA metabolic process (GO:0016072)	3.92495120
34	DNA strand elongation involved in DNA replication (GO:0006271)	3.83264518
35	cellular component biogenesis (GO:0044085)	3.81646520
36	telomere maintenance via semi-conservative replication (GO:0032201)	3.80240798
37	DNA strand elongation (GO:0022616)	3.64705646
38	regulation of mitochondrial translation (GO:0070129)	3.63676212
39	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.54596263
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.54596263
41	NADH dehydrogenase complex assembly (GO:0010257)	3.54596263
42	DNA unwinding involved in DNA replication (GO:0006268)	3.48395939
43	protein complex biogenesis (GO:0070271)	3.48322217
44	* establishment of protein localization to membrane (GO:0090150)	3.45476583
45	mitochondrial respiratory chain complex assembly (GO:0033108)	3.42506350
46	protein neddylation (GO:0045116)	3.39792004
47	DNA replication initiation (GO:0006270)	3.38581617
48	telomere maintenance via recombination (GO:0000722)	3.32675876
49	spliceosomal snRNP assembly (GO:0000387)	3.25823829
50	oxidative phosphorylation (GO:0006119)	3.25746975
51	ATP biosynthetic process (GO:0006754)	3.24413327
52	* establishment of protein localization to organelle (GO:0072594)	3.24126544
53	* protein targeting (GO:0006605)	3.20636537
54	inner mitochondrial membrane organization (GO:0007007)	3.19180634
55	protein targeting to mitochondrion (GO:0006626)	3.15809259
56	establishment of integrated proviral latency (GO:0075713)	3.15150101
57	ncRNA 3-end processing (GO:0043628)	3.14237446
58	mitotic recombination (GO:0006312)	3.14178405
59	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.13778123
60	pseudouridine synthesis (GO:0001522)	3.11466487
61	ribosome biogenesis (GO:0042254)	3.11359905
62	spliceosomal complex assembly (GO:0000245)	3.10558119
63	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.10393836
64	negative regulation of RNA splicing (GO:0033119)	3.07823427
65	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.06967906
66	telomere maintenance via telomere lengthening (GO:0010833)	3.02326243
67	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.01276821
68	establishment of protein localization to mitochondrion (GO:0072655)	2.99604118
69	CENP-A containing nucleosome assembly (GO:0034080)	2.98557239
70	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.96194925
71	chromatin remodeling at centromere (GO:0031055)	2.95989713
72	* protein localization to organelle (GO:0033365)	2.92965454
73	protein localization to kinetochore (GO:0034501)	2.91595142
74	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.89167646
75	termination of RNA polymerase III transcription (GO:0006386)	2.89167646
76	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.88659300
77	ribosome assembly (GO:0042255)	2.88402690
78	protein localization to mitochondrion (GO:0070585)	2.86982188
79	heterochromatin organization (GO:0070828)	2.83543834
80	kinetochore organization (GO:0051383)	2.82654714
81	DNA replication checkpoint (GO:0000076)	2.82515023
82	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.82296046
83	ATP synthesis coupled proton transport (GO:0015986)	2.82296046
84	nucleobase biosynthetic process (GO:0046112)	2.81534347
85	proteasome assembly (GO:0043248)	2.80623135
86	ncRNA processing (GO:0034470)	2.80109114
87	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.79656788
88	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.74701581
89	DNA replication-dependent nucleosome organization (GO:0034723)	2.73287636
90	DNA replication-dependent nucleosome assembly (GO:0006335)	2.73287636
91	aerobic respiration (GO:0009060)	2.73207647
92	folic acid-containing compound biosynthetic process (GO:0009396)	2.72470690
93	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.70867066
94	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.70142985
95	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.69911173
96	DNA replication-independent nucleosome assembly (GO:0006336)	2.69454068
97	DNA replication-independent nucleosome organization (GO:0034724)	2.69454068
98	transcription-coupled nucleotide-excision repair (GO:0006283)	2.69244203
99	hydrogen ion transmembrane transport (GO:1902600)	2.68202592
100	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.66912191
101	* gene expression (GO:0010467)	2.66838700
102	DNA damage response, detection of DNA damage (GO:0042769)	2.65979380
103	termination of RNA polymerase II transcription (GO:0006369)	2.64969437
104	histone exchange (GO:0043486)	2.64798250
105	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.64163343
106	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.64163343
107	nucleoside triphosphate biosynthetic process (GO:0009142)	2.63537825
108	histone mRNA metabolic process (GO:0008334)	2.62394026
109	* cellular component disassembly (GO:0022411)	2.62140765
110	ribonucleoprotein complex assembly (GO:0022618)	2.61649602
111	kinetochore assembly (GO:0051382)	2.60414622
112	UTP metabolic process (GO:0046051)	2.59654180
113	ncRNA metabolic process (GO:0034660)	2.59601501
114	UTP biosynthetic process (GO:0006228)	2.59051828
115	* protein localization to membrane (GO:0072657)	2.58721722
116	pyrimidine nucleotide catabolic process (GO:0006244)	2.58213955
117	mRNA splicing, via spliceosome (GO:0000398)	2.57269064
118	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)	2.57269064
119	RNA splicing, via transesterification reactions (GO:0000375)	2.57208252
120	IMP biosynthetic process (GO:0006188)	2.56087080
121	termination of RNA polymerase I transcription (GO:0006363)	2.52760973
122	purine nucleobase biosynthetic process (GO:0009113)	2.52567071
123	DNA-templated transcription, termination (GO:0006353)	2.52293955
124	protein localization to chromosome, centromeric region (GO:0071459)	2.51319573
125	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.50365309
126	negative regulation of ligase activity (GO:0051352)	2.50365309
127	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.50163958
128	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.50132955
129	rRNA modification (GO:0000154)	2.49799880
130	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.49365217
131	mitotic nuclear envelope disassembly (GO:0007077)	2.48674279
132	GTP biosynthetic process (GO:0006183)	2.47843231
133	ribonucleoprotein complex subunit organization (GO:0071826)	2.46402534
134	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	2.46268628
135	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.46162428

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.74778647
2	* MYC_18555785_ChIP-Seq_MESCs_Mouse	4.92676687
3	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	4.07421013
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.66347620
5	* MYC_19079543_ChIP-ChIP_MESCs_Mouse	3.54566064
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.28706976
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.21280989
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.14613947
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.02713918
10	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.98583069
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.97629723
12	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.96976672
13	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.88318255
14	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.77264822
15	XRN2_22483619_ChIP-Seq_HELA_Human	2.72558095
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.71930706
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.63757903
18	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.62056967
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.55454595
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.35824637
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.33337400
22	TTF2_22483619_ChIP-Seq_HELA_Human	2.23376800
23	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.22789976
24	DCP1A_22483619_ChIP-Seq_HELA_Human	2.11577445
25	* E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.06152769
26	* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.05539598
27	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	2.05409824
28	FOXP3_21729870_ChIP-Seq_TREG_Human	2.02818946
29	ELK1_19687146_ChIP-ChIP_HELA_Human	2.01524946
30	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.00602392
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.95005038
32	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.88371048
33	* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.83866845
34	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.73071618
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.67838521
36	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.59748565
37	* HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.56971174
38	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.56198147
39	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.55547928
40	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.54955556
41	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.54280431
42	MYC_22102868_ChIP-Seq_BL_Human	1.50884095
43	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.50522539
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.48538278
45	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.47829573
46	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.47503568
47	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.47196274
48	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.45006299
49	AR_21909140_ChIP-Seq_LNCAP_Human	1.43986604
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.43314755
51	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.43039434
52	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.41193342
53	CIITA_25753668_ChIP-Seq_RAJI_Human	1.39263622
54	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.34720215
55	* KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.34415159
56	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.32498323
57	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.32258287
58	* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.32232914
59	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.31428342
60	* SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.31396630
61	* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.30321395
62	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.29862029
63	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.29255871
64	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.28856848
65	VDR_21846776_ChIP-Seq_THP-1_Human	1.26175690
66	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.25290823
67	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.23850790
68	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.18244519
69	MYC_18940864_ChIP-ChIP_HL60_Human	1.18106229
70	KDM5A_27292631_Chip-Seq_BREAST_Human	1.17875739
71	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.14691808
72	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.13357669
73	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.12920504
74	* SPI1_23547873_ChIP-Seq_NB4_Human	1.12422940
75	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.11343109
76	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.10560578
77	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.10285293
78	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.10006950
79	* CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.08528344
80	* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.05458803
81	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.04987220
82	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.03042030
83	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.01702534
84	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.00333604
85	* ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.99365863
86	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.99333815
87	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.99079335
88	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.96875168
89	* SOX2_16153702_ChIP-ChIP_HESCs_Human	0.96826132
90	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.96685880
91	TFEB_21752829_ChIP-Seq_HELA_Human	0.95492662
92	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.95436945
93	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.94854238
94	ZNF263_19887448_ChIP-Seq_K562_Human	0.94692348
95	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.93576802
96	* IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.92979454
97	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.92809600
98	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.92300253
99	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.90201623
100	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.89180500
101	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.88971317
102	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.87289900
103	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.87094945
104	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.87094945
105	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.87094945
106	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.87057484
107	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.85638556
108	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.85463623
109	SCL_19346495_ChIP-Seq_HPC-7_Human	0.84092309
110	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.84032111
111	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.82030500
112	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.81663963
113	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.80966724
114	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.78976414
115	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.78102824
116	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.75688116
117	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.73333408
118	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.73117846
119	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.72166340

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.10156014
2	MP0003693_abnormal_embryo_hatching	4.62738283
3	MP0004957_abnormal_blastocyst_morpholog	3.82550044
4	MP0010094_abnormal_chromosome_stability	3.30284108
5	MP0003077_abnormal_cell_cycle	3.11594051
6	MP0003111_abnormal_nucleus_morphology	3.02858021
7	MP0008057_abnormal_DNA_replication	2.75666557
8	MP0002396_abnormal_hematopoietic_system	2.66939869
9	MP0008058_abnormal_DNA_repair	2.40855656
10	MP0000566_synostosis	2.33797861
11	MP0008007_abnormal_cellular_replicative	2.27375277
12	MP0008932_abnormal_embryonic_tissue	2.14719242
13	MP0000490_abnormal_crypts_of	2.04449750
14	MP0003786_premature_aging	1.83991756
15	MP0010352_gastrointestinal_tract_polyps	1.75425534
16	MP0004808_abnormal_hematopoietic_stem	1.70520018
17	MP0008789_abnormal_olfactory_epithelium	1.70397650
18	MP0000350_abnormal_cell_proliferation	1.67706169
19	MP0003763_abnormal_thymus_physiology	1.63037603
20	MP0002653_abnormal_ependyma_morphology	1.62176651
21	MP0009333_abnormal_splenocyte_physiolog	1.60125280
22	MP0003123_paternal_imprinting	1.58068640
23	MP0001730_embryonic_growth_arrest	1.56361647
24	MP0002697_abnormal_eye_size	1.48392777
25	MP0001286_abnormal_eye_development	1.48083019
26	MP0003567_abnormal_fetal_cardiomyocyte	1.47769623
27	MP0006054_spinal_hemorrhage	1.47140249
28	MP0003941_abnormal_skin_development	1.46123072
29	MP0005174_abnormal_tail_pigmentation	1.44070636
30	MP0002132_abnormal_respiratory_system	1.42982619
31	MP0001545_abnormal_hematopoietic_system	1.42674669
32	MP0005397_hematopoietic_system_phenotyp	1.42674669
33	MP0003938_abnormal_ear_development	1.41386755
34	MP0001346_abnormal_lacrimal_gland	1.38406545
35	MP0005394_taste/olfaction_phenotype	1.37114834
36	MP0005499_abnormal_olfactory_system	1.37114834
37	MP0002019_abnormal_tumor_incidence	1.34875951
38	MP0002160_abnormal_reproductive_system	1.34420335
39	MP0002398_abnormal_bone_marrow	1.30148722
40	MP0002234_abnormal_pharynx_morphology	1.29559009
41	MP0002722_abnormal_immune_system	1.27699592
42	MP0000703_abnormal_thymus_morphology	1.27149725
43	MP0000313_abnormal_cell_death	1.25835670
44	MP0003937_abnormal_limbs/digits/tail_de	1.25417001
45	MP0001529_abnormal_vocalization	1.24905640
46	MP0000631_abnormal_neuroendocrine_gland	1.24613830
47	MP0001853_heart_inflammation	1.22203429
48	MP0010030_abnormal_orbit_morphology	1.20797871
49	MP0001697_abnormal_embryo_size	1.20737104
50	MP0002210_abnormal_sex_determination	1.20172610
51	MP0002095_abnormal_skin_pigmentation	1.16522597
52	MP0002080_prenatal_lethality	1.16410515
53	MP0000858_altered_metastatic_potential	1.15712950
54	MP0000689_abnormal_spleen_morphology	1.15438218
55	MP0001835_abnormal_antigen_presentation	1.12955562
56	MP0002938_white_spotting	1.11157122
57	MP0003315_abnormal_perineum_morphology	1.11041738
58	MP0003890_abnormal_embryonic-extraembry	1.10834121
59	MP0003186_abnormal_redox_activity	1.10328119
60	MP0001800_abnormal_humoral_immune	1.10165527
61	MP0010307_abnormal_tumor_latency	1.09522365
62	MP0002166_altered_tumor_susceptibility	1.09384122
63	MP0000685_abnormal_immune_system	1.08308566
64	MP0001672_abnormal_embryogenesis/_devel	1.07793001
65	MP0005380_embryogenesis_phenotype	1.07793001
66	MP0006072_abnormal_retinal_apoptosis	1.07792042
67	MP0000465_gastrointestinal_hemorrhage	1.06163008
68	MP0002429_abnormal_blood_cell	1.06058465
69	MP0002233_abnormal_nose_morphology	1.05905896
70	MP0003942_abnormal_urinary_system	1.04345567
71	MP0002085_abnormal_embryonic_tissue	1.03283227
72	MP0005075_abnormal_melanosome_morpholog	1.02297821
73	MP0002092_abnormal_eye_morphology	1.00593215
74	MP0003136_yellow_coat_color	1.00427413
75	MP0005501_abnormal_skin_physiology	0.99922112
76	MP0004142_abnormal_muscle_tone	0.99220432
77	MP0002086_abnormal_extraembryonic_tissu	0.98470804
78	MP0000372_irregular_coat_pigmentation	0.98257866
79	MP0000716_abnormal_immune_system	0.97488811
80	MP0005408_hypopigmentation	0.97443370
81	MP0003718_maternal_effect	0.96322091
82	MP0004197_abnormal_fetal_growth/weight/	0.95693421
83	MP0001873_stomach_inflammation	0.95642790
84	MP0003984_embryonic_growth_retardation	0.94677306
85	MP0002420_abnormal_adaptive_immunity	0.94508242
86	MP0002088_abnormal_embryonic_growth/wei	0.94503320
87	MP0002452_abnormal_antigen_presenting	0.94322783
88	MP0002084_abnormal_developmental_patter	0.93802883
89	MP0002006_tumorigenesis	0.93412274
90	MP0005023_abnormal_wound_healing	0.92879720
91	MP0001145_abnormal_male_reproductive	0.92694722
92	MP0002405_respiratory_system_inflammati	0.92547908
93	MP0001819_abnormal_immune_cell	0.92281256
94	MP0006035_abnormal_mitochondrial_morpho	0.91428605
95	MP0001188_hyperpigmentation	0.90647054
96	MP0010155_abnormal_intestine_physiology	0.89836520
97	MP0009250_abnormal_appendicular_skeleto	0.89602875
98	MP0004381_abnormal_hair_follicle	0.89359606
99	MP0003011_delayed_dark_adaptation	0.88571780
100	MP0005671_abnormal_response_to	0.88351677
101	MP0001293_anophthalmia	0.87636034
102	MP0003755_abnormal_palate_morphology	0.86884458
103	MP0005389_reproductive_system_phenotype	0.86080197
104	MP0000750_abnormal_muscle_regeneration	0.83488458
105	MP0003861_abnormal_nervous_system	0.83431224
106	MP0003806_abnormal_nucleotide_metabolis	0.83368920
107	MP0003121_genomic_imprinting	0.82948128
108	MP0009785_altered_susceptibility_to	0.82560832
109	MP0002723_abnormal_immune_serum	0.82080091
110	MP0001485_abnormal_pinna_reflex	0.81711357
111	MP0005025_abnormal_response_to	0.80784647
112	MP0000653_abnormal_sex_gland	0.80376243
113	MP0003436_decreased_susceptibility_to	0.80238392
114	MP0002277_abnormal_respiratory_mucosa	0.79993994
115	MP0000049_abnormal_middle_ear	0.79404475
116	MP0002148_abnormal_hypersensitivity_rea	0.78809464
117	MP0000678_abnormal_parathyroid_gland	0.75666632
118	MP0005391_vision/eye_phenotype	0.75659350
119	MP0000762_abnormal_tongue_morphology	0.75584330
120	MP0003119_abnormal_digestive_system	0.74815479
121	MP0005000_abnormal_immune_tolerance	0.74759061
122	MP0000358_abnormal_cell_content/	0.74557188
123	MP0008995_early_reproductive_senescence	0.74411037
124	MP0000537_abnormal_urethra_morphology	0.74254887
125	MP0002282_abnormal_trachea_morphology	0.73960956
126	MP0005076_abnormal_cell_differentiation	0.73847208
127	MP0002796_impaired_skin_barrier	0.73646386
128	MP0000477_abnormal_intestine_morphology	0.73265772
129	MP0009278_abnormal_bone_marrow	0.72742756
130	MP0001929_abnormal_gametogenesis	0.72102133
131	MP0002163_abnormal_gland_morphology	0.71973009
132	MP0001919_abnormal_reproductive_system	0.71125429
133	MP0002111_abnormal_tail_morphology	0.70687068
134	MP0002116_abnormal_craniofacial_bone	0.68814103
135	MP0000428_abnormal_craniofacial_morphol	0.68216435
136	MP0009053_abnormal_anal_canal	0.67864764
137	MP0001216_abnormal_epidermal_layer	0.67712407
138	MP0002638_abnormal_pupillary_reflex	0.67531791
139	MP0001881_abnormal_mammary_gland	0.66564833
140	MP0000026_abnormal_inner_ear	0.66189474
141	MP0003385_abnormal_body_wall	0.65554472
142	MP0002060_abnormal_skin_morphology	0.65413769
143	MP0009697_abnormal_copulation	0.64077386
144	MP0005377_hearing/vestibular/ear_phenot	0.63894636
145	MP0003878_abnormal_ear_physiology	0.63894636
146	MP0006292_abnormal_olfactory_placode	0.63879668
147	MP0002098_abnormal_vibrissa_morphology	0.63875049
148	MP0002249_abnormal_larynx_morphology	0.63824026
149	MP0005379_endocrine/exocrine_gland_phen	0.63721935
150	MP0006036_abnormal_mitochondrial_physio	0.63312321
151	MP0009672_abnormal_birth_weight	0.62333224
152	MP0000778_abnormal_nervous_system	0.61268102
153	MP0003283_abnormal_digestive_organ	0.60295691
154	MP0009931_abnormal_skin_appearance	0.59806976
155	MP0003936_abnormal_reproductive_system	0.59423876
156	MP0002932_abnormal_joint_morphology	0.58649128

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of cells of the erythroid lineage (HP:0012130)	9.34724456
2	Reticulocytopenia (HP:0001896)	8.50561984
3	Abnormal number of erythroid precursors (HP:0012131)	8.34707548
4	Macrocytic anemia (HP:0001972)	6.31628711
5	Pallor (HP:0000980)	5.98965810
6	Abnormal hemoglobin (HP:0011902)	3.79691967
7	Thrombocytosis (HP:0001894)	3.71646724
8	Colon cancer (HP:0003003)	3.66331817
9	Aplastic anemia (HP:0001915)	3.50686755
10	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.29167154
11	Cerebral edema (HP:0002181)	3.23320557
12	Oral leukoplakia (HP:0002745)	3.15602082
13	11 pairs of ribs (HP:0000878)	3.12440538
14	Absent thumb (HP:0009777)	3.06567334
15	Abnormality of reticulocytes (HP:0004312)	3.02068000
16	Septo-optic dysplasia (HP:0100842)	2.88608035
17	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.82648715
18	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.82648715
19	Trismus (HP:0000211)	2.80905390
20	Congenital, generalized hypertrichosis (HP:0004540)	2.80237117
21	Multiple enchondromatosis (HP:0005701)	2.79104033
22	Depressed nasal ridge (HP:0000457)	2.72322959
23	Increased hepatocellular lipid droplets (HP:0006565)	2.70666770
24	Increased muscle lipid content (HP:0009058)	2.61152621
25	Selective tooth agenesis (HP:0001592)	2.60119732
26	Birth length less than 3rd percentile (HP:0003561)	2.56329859
27	Stenosis of the external auditory canal (HP:0000402)	2.52775378
28	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.51549741
29	Rough bone trabeculation (HP:0100670)	2.46322216
30	IgM deficiency (HP:0002850)	2.46293882
31	Mitochondrial inheritance (HP:0001427)	2.42242436
32	Leukodystrophy (HP:0002415)	2.39040392
33	Microretrognathia (HP:0000308)	2.37443999
34	Breast hypoplasia (HP:0003187)	2.36530553
35	Lactic acidosis (HP:0003128)	2.35749374
36	Exertional dyspnea (HP:0002875)	2.35328465
37	Duplication of thumb phalanx (HP:0009942)	2.32439115
38	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.32045915
39	Acute necrotizing encephalopathy (HP:0006965)	2.31287186
40	Respiratory failure (HP:0002878)	2.28225726
41	Lipid accumulation in hepatocytes (HP:0006561)	2.27873476
42	Triphalangeal thumb (HP:0001199)	2.26707493
43	Myelodysplasia (HP:0002863)	2.26608815
44	Thick lower lip vermilion (HP:0000179)	2.25793726
45	Migraine (HP:0002076)	2.24923930
46	Asplenia (HP:0001746)	2.24894568
47	Hypoplasia of the radius (HP:0002984)	2.24172379
48	Carpal bone hypoplasia (HP:0001498)	2.23009237
49	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.22671131
50	Hepatocellular necrosis (HP:0001404)	2.18333892
51	Increased CSF lactate (HP:0002490)	2.16710551
52	Glossoptosis (HP:0000162)	2.16599069
53	Optic disc pallor (HP:0000543)	2.14644502
54	Abnormality of the preputium (HP:0100587)	2.14047914
55	Abnormality of the parietal bone (HP:0002696)	2.08994021
56	Abnormality of renal resorption (HP:0011038)	2.08796176
57	Maternal diabetes (HP:0009800)	2.08610915
58	Absent septum pellucidum (HP:0001331)	2.08083371
59	Neoplasm of the pancreas (HP:0002894)	2.06132378
60	Rib fusion (HP:0000902)	2.05948040
61	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.04283218
62	Abnormal mitochondria in muscle tissue (HP:0008316)	2.03957680
63	Poikiloderma (HP:0001029)	2.01773444
64	Respiratory difficulties (HP:0002880)	2.01687440
65	Woolly hair (HP:0002224)	1.99775983
66	Patellar aplasia (HP:0006443)	1.97980064
67	Atresia of the external auditory canal (HP:0000413)	1.97809014
68	Chromsome breakage (HP:0040012)	1.97249066
69	Sparse eyelashes (HP:0000653)	1.96494468
70	Missing ribs (HP:0000921)	1.96311128
71	Premature graying of hair (HP:0002216)	1.95582807
72	Basal cell carcinoma (HP:0002671)	1.94916200
73	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.92877430
74	Cleft eyelid (HP:0000625)	1.92745879
75	3-Methylglutaconic aciduria (HP:0003535)	1.91274893
76	Meckel diverticulum (HP:0002245)	1.90640160
77	Anophthalmia (HP:0000528)	1.88138070
78	Aplasia/Hypoplasia of the patella (HP:0006498)	1.88059187
79	Abnormal number of incisors (HP:0011064)	1.87215891
80	Type I transferrin isoform profile (HP:0003642)	1.86999866
81	Abnormality of the septum pellucidum (HP:0007375)	1.86395562
82	Increased serum lactate (HP:0002151)	1.85854370
83	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.85706996
84	Abnormality of cochlea (HP:0000375)	1.84845991
85	Progressive macrocephaly (HP:0004481)	1.84504211
86	Abnormality of chromosome stability (HP:0003220)	1.84173347
87	Abnormality of the ileum (HP:0001549)	1.83646695
88	Increased intramyocellular lipid droplets (HP:0012240)	1.83144630
89	Hepatic necrosis (HP:0002605)	1.82783622
90	Petechiae (HP:0000967)	1.82224306
91	Pancytopenia (HP:0001876)	1.82009840
92	Hyperphosphaturia (HP:0003109)	1.81283792
93	Bilateral microphthalmos (HP:0007633)	1.80613048
94	Squamous cell carcinoma (HP:0002860)	1.80062191
95	Agnosia (HP:0010524)	1.77561327
96	Renal Fanconi syndrome (HP:0001994)	1.77067365
97	Esophageal atresia (HP:0002032)	1.76626664
98	Medulloblastoma (HP:0002885)	1.75511434
99	Horseshoe kidney (HP:0000085)	1.74311257
100	Nasolacrimal duct obstruction (HP:0000579)	1.74095539
101	Lymphoma (HP:0002665)	1.73220355
102	Abnormal trabecular bone morphology (HP:0100671)	1.73202736
103	Partial duplication of the phalanx of hand (HP:0009999)	1.73167094
104	Broad distal phalanx of finger (HP:0009836)	1.73062848
105	Cellular immunodeficiency (HP:0005374)	1.71423090
106	Premature ovarian failure (HP:0008209)	1.70333843
107	Exercise intolerance (HP:0003546)	1.69931185
108	Short middle phalanx of the 5th finger (HP:0004220)	1.68828784
109	Abnormality of the axillary hair (HP:0100134)	1.67829704
110	Abnormality of secondary sexual hair (HP:0009888)	1.67829704
111	Sparse lateral eyebrow (HP:0005338)	1.67381722
112	Hyperglycinemia (HP:0002154)	1.67224590
113	Microvesicular hepatic steatosis (HP:0001414)	1.66816909
114	Tracheoesophageal fistula (HP:0002575)	1.66761987
115	Short thumb (HP:0009778)	1.66170141
116	Facial cleft (HP:0002006)	1.65832666
117	Acute encephalopathy (HP:0006846)	1.65622108
118	Partial duplication of thumb phalanx (HP:0009944)	1.65027977
119	Secondary amenorrhea (HP:0000869)	1.64360851
120	Lethargy (HP:0001254)	1.63934457
121	Ectopic kidney (HP:0000086)	1.63886076
122	Progressive muscle weakness (HP:0003323)	1.62879971
123	Muscle fiber atrophy (HP:0100295)	1.62584511
124	Abnormality of urine glucose concentration (HP:0011016)	1.62469580
125	Glycosuria (HP:0003076)	1.62469580
126	Ependymoma (HP:0002888)	1.61909659
127	Abnormality of the anterior horn cell (HP:0006802)	1.60749917
128	Degeneration of anterior horn cells (HP:0002398)	1.60749917
129	Absent radius (HP:0003974)	1.60702257
130	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.60639080
131	Neoplasm of the colon (HP:0100273)	1.60005134
132	Morphological abnormality of the inner ear (HP:0011390)	1.59661756
133	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.59163717
134	Abnormality of the lacrimal duct (HP:0011481)	1.59069703
135	Megaloblastic anemia (HP:0001889)	1.58956847
136	Amaurosis fugax (HP:0100576)	1.58778944
137	Rhabdomyosarcoma (HP:0002859)	1.57063551
138	Forearm undergrowth (HP:0009821)	1.55105893
139	Hypoplasia of the pons (HP:0012110)	1.53350565
140	Sclerocornea (HP:0000647)	1.52702692

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	5.39824448
2	VRK2	4.85712848
3	WEE1	3.46030791
4	BUB1	3.20994259
5	RPS6KB2	2.89891411
6	TLK1	2.82983199
7	CDC7	2.56310328
8	EIF2AK1	2.55861507
9	EEF2K	2.47245029
10	SRPK1	2.32310778
11	STK16	2.29414865
12	VRK1	2.21352398
13	LRRK2	2.14582474
14	TAF1	2.05601109
15	PIM2	1.99436765
16	TGFBR1	1.96058247
17	NEK2	1.81884663
18	DYRK3	1.81673719
19	EIF2AK3	1.73841161
20	DYRK2	1.59908490
21	PASK	1.59063760
22	ACVR1B	1.58541474
23	AURKB	1.58469992
24	MST4	1.58058646
25	RPS6KA4	1.57759811
26	CDK7	1.55768900
27	MKNK1	1.54079134
28	MAPKAPK3	1.45486649
29	MAP4K1	1.45042622
30	BRSK2	1.37838608
31	TSSK6	1.33318577
32	PLK1	1.31725906
33	FLT3	1.30418828
34	EPHB2	1.27779511
35	TESK2	1.27447925
36	TTK	1.23459356
37	STK10	1.21253516
38	ILK	1.12596991
39	ATR	1.12577450
40	PNCK	1.11204836
41	MAP3K8	1.06804716
42	PIM1	1.06660257
43	TEC	1.06386044
44	KDR	1.06110378
45	MAP3K10	1.05529639
46	PAK4	1.05259787
47	SCYL2	1.05181517
48	PLK4	1.00339455
49	BTK	0.99820007
50	AURKA	0.99220897
51	PDK2	0.98943097
52	NME1	0.98852372
53	SMG1	0.98723131
54	NUAK1	0.97173559
55	CDK4	0.96738057
56	PKN2	0.95743004
57	CDK8	0.90486773
58	EPHA2	0.89426288
59	CDK19	0.89124252
60	MKNK2	0.88387948
61	STK24	0.85281425
62	CSNK2A2	0.83950767
63	RPS6KA5	0.83191053
64	STK4	0.83183192
65	EIF2AK2	0.81254304
66	PBK	0.80931926
67	CHEK2	0.77940488
68	KIT	0.77246313
69	BRAF	0.73518632
70	NEK1	0.72881056
71	CSNK2A1	0.71561055
72	WNK4	0.71362326
73	ZAK	0.71196637
74	MAP2K3	0.70088323
75	CHEK1	0.70062272
76	CDK3	0.68167796
77	CSNK1E	0.68029981
78	IKBKB	0.67297933
79	GRK6	0.67221730
80	MAP3K11	0.66949215
81	TYRO3	0.66584623
82	BLK	0.63879534
83	PAK1	0.63417964
84	CCNB1	0.60816849
85	PAK2	0.60549997
86	PLK3	0.58364036
87	CSF1R	0.58165475
88	BRSK1	0.57756105
89	CDK6	0.57391567
90	MAP3K3	0.57163874
91	CDK1	0.54376793
92	TNIK	0.53944872
93	MAPK15	0.53810814
94	ATM	0.52857602
95	ZAP70	0.51832755
96	NLK	0.51632161
97	TYK2	0.50097228
98	CDK2	0.46570312
99	ARAF	0.42469468
100	LYN	0.42386095
101	MATK	0.41854973
102	MAP2K2	0.41731500
103	IRAK3	0.40769784
104	CDK11A	0.40470859
105	CDK12	0.40370571
106	SYK	0.40186684
107	RPS6KC1	0.38983509
108	RPS6KL1	0.38983509
109	TGFBR2	0.38940094
110	PRKCI	0.38206285
111	ABL2	0.38199801
112	RPS6KA6	0.36007977
113	IRAK4	0.35584273
114	CLK1	0.35191656
115	BCKDK	0.35153690
116	DAPK3	0.34870704
117	PRKDC	0.34444960
118	ALK	0.34291951
119	STK3	0.34047408
120	MAPKAPK2	0.33894951
121	JAK3	0.33138815
122	DMPK	0.32762495
123	LCK	0.32359357
124	MAPKAPK5	0.31623099
125	AKT2	0.30065570
126	TRIB3	0.27817375
127	MAPK14	0.26999424
128	DYRK1B	0.26980111
129	BMPR1B	0.26613011
130	RPS6KA1	0.26038035
131	CDK15	0.26037708
132	MUSK	0.24947065
133	AKT1	0.24671294
134	PRKCG	0.21724612
135	CDK9	0.21555066
136	FGFR1	0.18632156
137	CDK14	0.18572486

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Ribosome_Homo sapiens_hsa03010	7.66121326
2	DNA replication_Homo sapiens_hsa03030	4.10636848
3	Mismatch repair_Homo sapiens_hsa03430	3.49221341
4	RNA polymerase_Homo sapiens_hsa03020	3.18236231
5	Spliceosome_Homo sapiens_hsa03040	3.14891136
6	Proteasome_Homo sapiens_hsa03050	3.12956405
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.85202285
8	Homologous recombination_Homo sapiens_hsa03440	2.58133979
9	Nucleotide excision repair_Homo sapiens_hsa03420	2.48473007
10	Base excision repair_Homo sapiens_hsa03410	2.39235720
11	Pyrimidine metabolism_Homo sapiens_hsa00240	2.36849544
12	RNA transport_Homo sapiens_hsa03013	2.33767603
13	One carbon pool by folate_Homo sapiens_hsa00670	2.01283532
14	Non-homologous end-joining_Homo sapiens_hsa03450	1.76002778
15	Cell cycle_Homo sapiens_hsa04110	1.74215198
16	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.73313879
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.72076784
18	Parkinsons disease_Homo sapiens_hsa05012	1.67529815
19	Oxidative phosphorylation_Homo sapiens_hsa00190	1.63102614
20	RNA degradation_Homo sapiens_hsa03018	1.58332609
21	Protein export_Homo sapiens_hsa03060	1.51064106
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.46045616
23	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.45574266
24	Huntingtons disease_Homo sapiens_hsa05016	1.38595160
25	p53 signaling pathway_Homo sapiens_hsa04115	1.38451971
26	Basal transcription factors_Homo sapiens_hsa03022	1.37444432
27	Purine metabolism_Homo sapiens_hsa00230	1.13138827
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.08069072
29	mRNA surveillance pathway_Homo sapiens_hsa03015	1.04888056
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.00064643
31	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.99704934
32	Primary immunodeficiency_Homo sapiens_hsa05340	0.97580295
33	Alzheimers disease_Homo sapiens_hsa05010	0.97541871
34	Sulfur relay system_Homo sapiens_hsa04122	0.94564484
35	Antigen processing and presentation_Homo sapiens_hsa04612	0.93821886
36	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.92116051
37	Herpes simplex infection_Homo sapiens_hsa05168	0.91233531
38	Folate biosynthesis_Homo sapiens_hsa00790	0.89902333
39	Pyruvate metabolism_Homo sapiens_hsa00620	0.75689188
40	Viral carcinogenesis_Homo sapiens_hsa05203	0.74162275
41	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.68518117
42	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.65639006
43	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.62763325
44	HTLV-I infection_Homo sapiens_hsa05166	0.61752380
45	Pentose phosphate pathway_Homo sapiens_hsa00030	0.60674108
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60233695
47	Thyroid cancer_Homo sapiens_hsa05216	0.59618208
48	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.59616620
49	Glutathione metabolism_Homo sapiens_hsa00480	0.59453490
50	Small cell lung cancer_Homo sapiens_hsa05222	0.57475176
51	Legionellosis_Homo sapiens_hsa05134	0.56178280
52	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.54616640
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53037854
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.52224680
55	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.49669776
56	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.48800028
57	Alcoholism_Homo sapiens_hsa05034	0.47759480
58	Measles_Homo sapiens_hsa05162	0.47607067
59	Apoptosis_Homo sapiens_hsa04210	0.46402073
60	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.45597205
61	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.45103164
62	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.44901380
63	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.43146163
64	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.41309546
65	Basal cell carcinoma_Homo sapiens_hsa05217	0.40554063
66	Carbon metabolism_Homo sapiens_hsa01200	0.40372716
67	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.38207239
68	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.36853811
69	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.36431529
70	MicroRNAs in cancer_Homo sapiens_hsa05206	0.34965008
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.34349415
72	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.34074449
73	Hepatitis B_Homo sapiens_hsa05161	0.33475426
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33280254
75	Bladder cancer_Homo sapiens_hsa05219	0.31933925
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.31417412
77	Acute myeloid leukemia_Homo sapiens_hsa05221	0.31130664
78	Asthma_Homo sapiens_hsa05310	0.29686891
79	Notch signaling pathway_Homo sapiens_hsa04330	0.29345493
80	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.29003895
81	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.28735477
82	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.27803701
83	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.27316562
84	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.27187535
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.26885099
86	Pathways in cancer_Homo sapiens_hsa05200	0.26709489
87	Shigellosis_Homo sapiens_hsa05131	0.26300997
88	Metabolic pathways_Homo sapiens_hsa01100	0.25962154
89	Allograft rejection_Homo sapiens_hsa05330	0.25824359
90	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.25792253
91	Wnt signaling pathway_Homo sapiens_hsa04310	0.25775168
92	Propanoate metabolism_Homo sapiens_hsa00640	0.25713316
93	Cardiac muscle contraction_Homo sapiens_hsa04260	0.25621317
94	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.24944686
95	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.24454709
96	Leishmaniasis_Homo sapiens_hsa05140	0.24104371
97	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.23905109
98	Selenocompound metabolism_Homo sapiens_hsa00450	0.23611027
99	Colorectal cancer_Homo sapiens_hsa05210	0.22344706
100	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.21677723
101	Oocyte meiosis_Homo sapiens_hsa04114	0.20792860
102	Fatty acid elongation_Homo sapiens_hsa00062	0.20099510
103	Influenza A_Homo sapiens_hsa05164	0.19893973
104	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.19698255
105	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.19583831
106	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.16665545
107	Renin-angiotensin system_Homo sapiens_hsa04614	0.16024878
108	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.15545773
109	Viral myocarditis_Homo sapiens_hsa05416	0.15431356
110	Fat digestion and absorption_Homo sapiens_hsa04975	0.14764687
111	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.14728120
112	Tyrosine metabolism_Homo sapiens_hsa00350	0.14239721
113	Arginine and proline metabolism_Homo sapiens_hsa00330	0.12984201
114	Linoleic acid metabolism_Homo sapiens_hsa00591	0.12888852
115	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.12518365
116	Hippo signaling pathway_Homo sapiens_hsa04390	0.12457126
117	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.12121519
118	Malaria_Homo sapiens_hsa05144	0.11901698
119	Toxoplasmosis_Homo sapiens_hsa05145	0.11409067
120	Nitrogen metabolism_Homo sapiens_hsa00910	0.11205852
121	Peroxisome_Homo sapiens_hsa04146	0.08895856
122	Phototransduction_Homo sapiens_hsa04744	0.08814371
123	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.08787669
124	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.08244874
125	Steroid biosynthesis_Homo sapiens_hsa00100	0.07101750
126	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.06335745
127	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.03883080
128	Galactose metabolism_Homo sapiens_hsa00052	0.01152243
129	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.00792195
130	Melanoma_Homo sapiens_hsa05218	0.00592031
131	Chemical carcinogenesis_Homo sapiens_hsa05204	-0.0337485
132	Butanoate metabolism_Homo sapiens_hsa00650	-0.0274362
133	Olfactory transduction_Homo sapiens_hsa04740	-0.0195323
134	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	-0.0122354
135	Collecting duct acid secretion_Homo sapiens_hsa04966	-0.0082942

RPL36A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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