ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	9.82878427
2	translational termination (GO:0006415)	9.38375737
3	maturation of SSU-rRNA (GO:0030490)	8.70036267
4	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	8.38850414
5	cotranslational protein targeting to membrane (GO:0006613)	8.27920711
6	protein targeting to ER (GO:0045047)	8.23925404
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	8.07422096
8	establishment of protein localization to endoplasmic reticulum (GO:0072599)	7.92128608
9	translational elongation (GO:0006414)	7.85644817
10	protein localization to endoplasmic reticulum (GO:0070972)	7.72302978
11	ribosomal large subunit biogenesis (GO:0042273)	7.48834501
12	cellular protein complex disassembly (GO:0043624)	7.21432923
13	viral life cycle (GO:0019058)	7.15876053
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	7.07338618
15	ribosomal small subunit assembly (GO:0000028)	6.95639637
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.78354588
17	ATP synthesis coupled proton transport (GO:0015986)	6.78354588
18	translational initiation (GO:0006413)	6.68468071
19	chaperone-mediated protein transport (GO:0072321)	6.09975224
20	protein complex disassembly (GO:0043241)	6.04116624
21	* translation (GO:0006412)	5.75241939
22	ribonucleoprotein complex biogenesis (GO:0022613)	5.72094040
23	macromolecular complex disassembly (GO:0032984)	5.72030051
24	protein targeting to membrane (GO:0006612)	5.59075333
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.48579078
26	respiratory electron transport chain (GO:0022904)	5.24115122
27	electron transport chain (GO:0022900)	5.10934076
28	cellular component biogenesis (GO:0044085)	4.96148334
29	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.92194298
30	mRNA catabolic process (GO:0006402)	4.65640005
31	rRNA processing (GO:0006364)	4.54195539
32	protein neddylation (GO:0045116)	4.39797928
33	rRNA metabolic process (GO:0016072)	4.36195790
34	mitochondrial respiratory chain complex assembly (GO:0033108)	4.35955550
35	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.31570220
36	regulation of mitochondrial translation (GO:0070129)	4.30689093
37	termination of RNA polymerase III transcription (GO:0006386)	4.30581594
38	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.30581594
39	RNA catabolic process (GO:0006401)	4.29991114
40	protein complex biogenesis (GO:0070271)	4.25530468
41	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.21740913
42	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.21740913
43	NADH dehydrogenase complex assembly (GO:0010257)	4.21740913
44	proteasome assembly (GO:0043248)	4.17518926
45	cullin deneddylation (GO:0010388)	4.15195965
46	protein targeting to mitochondrion (GO:0006626)	4.12303102
47	protein deneddylation (GO:0000338)	3.87475172
48	protein targeting (GO:0006605)	3.87102906
49	establishment of protein localization to membrane (GO:0090150)	3.79183265
50	spliceosomal snRNP assembly (GO:0000387)	3.72531120
51	water-soluble vitamin biosynthetic process (GO:0042364)	3.71537117
52	protein localization to mitochondrion (GO:0070585)	3.63753577
53	establishment of protein localization to mitochondrion (GO:0072655)	3.63221034
54	ATP biosynthetic process (GO:0006754)	3.60977109
55	pseudouridine synthesis (GO:0001522)	3.57452637
56	ribosome biogenesis (GO:0042254)	3.53884245
57	establishment of protein localization to organelle (GO:0072594)	3.52392477
58	formation of translation preinitiation complex (GO:0001731)	3.51061066
59	ncRNA 3-end processing (GO:0043628)	3.49409427
60	rRNA modification (GO:0000154)	3.43320427
61	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.41377711
62	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.32125093
63	mitochondrial transport (GO:0006839)	3.30346008
64	DNA damage response, detection of DNA damage (GO:0042769)	3.27718237
65	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.24225353
66	spliceosomal complex assembly (GO:0000245)	3.15275090
67	DNA replication checkpoint (GO:0000076)	3.11986065
68	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.09725178
69	ncRNA processing (GO:0034470)	3.09581303
70	hydrogen ion transmembrane transport (GO:1902600)	3.07671725
71	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.06321059
72	protein localization to membrane (GO:0072657)	2.97129136
73	rRNA methylation (GO:0031167)	2.93575096
74	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.93242525
75	protein-cofactor linkage (GO:0018065)	2.91484526
76	transcription from mitochondrial promoter (GO:0006390)	2.89387287
77	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.87399355
78	ncRNA metabolic process (GO:0034660)	2.84409599
79	DNA deamination (GO:0045006)	2.80442771
80	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.79833509
81	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.79833509
82	chromatin remodeling at centromere (GO:0031055)	2.78932634
83	negative regulation of ligase activity (GO:0051352)	2.78135207
84	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.78135207
85	DNA catabolic process, exonucleolytic (GO:0000738)	2.78066106
86	nucleoside triphosphate biosynthetic process (GO:0009142)	2.74402059
87	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.73815671
88	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.73815671
89	CENP-A containing nucleosome assembly (GO:0034080)	2.71403397
90	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.70587653
91	maturation of 5.8S rRNA (GO:0000460)	2.68445800
92	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.62318359
93	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.62143577
94	intracellular protein transmembrane import (GO:0044743)	2.62077773
95	proton transport (GO:0015992)	2.61805059
96	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.61001461
97	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.59092837
98	kinetochore assembly (GO:0051382)	2.58866213
99	regulation of cellular amino acid metabolic process (GO:0006521)	2.57734865
100	ribosomal small subunit biogenesis (GO:0042274)	10.2003482

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.59046708
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.03864952
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.90304167
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.86275475
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.55871750
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.53970419
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.88286709
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.68935654
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.52446614
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.44296413
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.25974685
12	MYC_19079543_ChIP-ChIP_MESCs_Mouse	3.18288284
13	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.07727834
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	3.04239690
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.94367949
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.91485034
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.89979748
18	XRN2_22483619_ChIP-Seq_HELA_Human	2.65506502
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.64686808
20	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.59169308
21	DCP1A_22483619_ChIP-Seq_HELA_Human	2.47245433
22	TTF2_22483619_ChIP-Seq_HELA_Human	2.46177559
23	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.44594016
24	FOXP3_21729870_ChIP-Seq_TREG_Human	2.42984277
25	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.35610437
26	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.21956038
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.18439600
28	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.11660064
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.00516661
30	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.97161144
31	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.90626265
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.90582007
33	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.85907481
34	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.84007473
35	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.80236320
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.69972416
37	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.69690437
38	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.69151813
39	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.67694505
40	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.67412985
41	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.62593400
42	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.61802593
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.61273426
44	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.59662684
45	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.58193098
46	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.55193015
47	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.53643246
48	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.50909465
49	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.48654175
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.35588219
51	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.32521841
52	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.30066364
53	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.29272886
54	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.26684618
55	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.26667834
56	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.26174695
57	ZNF263_19887448_ChIP-Seq_K562_Human	1.24247009
58	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.23503120
59	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.17899421
60	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.17026903
61	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.14717124
62	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.12901048
63	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.12451494
64	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.04584449
65	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.03481633
66	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.02964071
67	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.00408167
68	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.00313121
69	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.99723316
70	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.99040013
71	KDM5A_27292631_Chip-Seq_BREAST_Human	0.98821694
72	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.98164381
73	EWS_26573619_Chip-Seq_HEK293_Human	0.97196441
74	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.95362738
75	ELF5_23300383_ChIP-Seq_T47D_Human	0.95037661
76	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.89270737
77	AR_21909140_ChIP-Seq_LNCAP_Human	0.84182929
78	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.82863933
79	FUS_26573619_Chip-Seq_HEK293_Human	0.80889465
80	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.78375335
81	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.78226439
82	CIITA_25753668_ChIP-Seq_RAJI_Human	0.77989970
83	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.77601375
84	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.76390668
85	TFEB_21752829_ChIP-Seq_HELA_Human	0.76345713
86	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.76168386
87	IRF1_19129219_ChIP-ChIP_H3396_Human	0.75875981
88	E2F7_22180533_ChIP-Seq_HELA_Human	0.75440682
89	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.75076205
90	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.74870452
91	SPI1_23547873_ChIP-Seq_NB4_Human	0.73864935
92	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.73645679
93	TP53_22573176_ChIP-Seq_HFKS_Human	0.73098049
94	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.72992742
95	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.72898153
96	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.72788664
97	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.70616406
98	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.70373776
99	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.70064360
100	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.69308572

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.52306924
2	MP0003806_abnormal_nucleotide_metabolis	6.07719288
3	MP0003693_abnormal_embryo_hatching	3.23733974
4	MP0006036_abnormal_mitochondrial_physio	3.02687333
5	MP0004957_abnormal_blastocyst_morpholog	2.85280390
6	MP0003186_abnormal_redox_activity	2.81579925
7	MP0005671_abnormal_response_to	2.48180388
8	MP0003077_abnormal_cell_cycle	2.35896223
9	MP0002938_white_spotting	2.28881189
10	MP0010094_abnormal_chromosome_stability	2.28425305
11	MP0002160_abnormal_reproductive_system	2.26450881
12	MP0008058_abnormal_DNA_repair	2.22808598
13	MP0003111_abnormal_nucleus_morphology	2.21971569
14	MP0009697_abnormal_copulation	2.15418183
15	MP0009333_abnormal_splenocyte_physiolog	2.11842105
16	MP0002638_abnormal_pupillary_reflex	2.03406108
17	MP0008007_abnormal_cellular_replicative	1.98668331
18	MP0003718_maternal_effect	1.85026166
19	MP0010386_abnormal_urinary_bladder	1.84261439
20	MP0002148_abnormal_hypersensitivity_rea	1.84127569
21	MP0001835_abnormal_antigen_presentation	1.80291084
22	MP0003786_premature_aging	1.65039075
23	MP0002837_dystrophic_cardiac_calcinosis	1.63653840
24	MP0005389_reproductive_system_phenotype	1.61667220
25	MP0002876_abnormal_thyroid_physiology	1.59026567
26	MP0000685_abnormal_immune_system	1.58076758
27	MP0001905_abnormal_dopamine_level	1.57273064
28	MP0006072_abnormal_retinal_apoptosis	1.53298742
29	MP0009053_abnormal_anal_canal	1.44487234
30	MP0003315_abnormal_perineum_morphology	1.43571260
31	MP0002163_abnormal_gland_morphology	1.41207256
32	MP0009250_abnormal_appendicular_skeleto	1.41199305
33	MP0008875_abnormal_xenobiotic_pharmacok	1.40732103
34	MP0004145_abnormal_muscle_electrophysio	1.38131544
35	MP0005408_hypopigmentation	1.33198682
36	MP0005646_abnormal_pituitary_gland	1.32589068
37	MP0006292_abnormal_olfactory_placode	1.30337543
38	MP0001853_heart_inflammation	1.29032347
39	MP0009785_altered_susceptibility_to	1.27534988
40	MP0008932_abnormal_embryonic_tissue	1.26765154
41	MP0008873_increased_physiological_sensi	1.21394258
42	MP0008789_abnormal_olfactory_epithelium	1.20767323
43	MP0001764_abnormal_homeostasis	1.19973747
44	MP0004142_abnormal_muscle_tone	1.17179011
45	MP0003567_abnormal_fetal_cardiomyocyte	1.15297427
46	MP0001919_abnormal_reproductive_system	1.09996791
47	MP0001800_abnormal_humoral_immune	1.09093599
48	MP0005084_abnormal_gallbladder_morpholo	1.08825928
49	MP0001881_abnormal_mammary_gland	1.07427694
50	MP0002277_abnormal_respiratory_mucosa	1.05984667
51	MP0002452_abnormal_antigen_presenting	1.03589508
52	MP0000678_abnormal_parathyroid_gland	1.02577147
53	MP0002095_abnormal_skin_pigmentation	1.01838034
54	MP0005623_abnormal_meninges_morphology	0.99920093
55	MP0000313_abnormal_cell_death	0.98549270
56	MP0003011_delayed_dark_adaptation	0.97707980
57	MP0001727_abnormal_embryo_implantation	0.96646312
58	MP0000350_abnormal_cell_proliferation	0.93603869
59	MP0003941_abnormal_skin_development	0.92981306
60	MP0005187_abnormal_penis_morphology	0.92633596
61	MP0005379_endocrine/exocrine_gland_phen	0.91325404
62	MP0000049_abnormal_middle_ear	0.90133809
63	MP0005332_abnormal_amino_acid	0.88734145
64	MP0002006_tumorigenesis	0.88081388
65	MP0005000_abnormal_immune_tolerance	0.88071311
66	MP0009764_decreased_sensitivity_to	0.87559264
67	MP0001529_abnormal_vocalization	0.87267785
68	MP0003763_abnormal_thymus_physiology	0.86488343
69	MP0002877_abnormal_melanocyte_morpholog	0.85704405
70	MP0002723_abnormal_immune_serum	0.85490344
71	MP0000516_abnormal_urinary_system	0.82755918
72	MP0005367_renal/urinary_system_phenotyp	0.82755918
73	MP0005636_abnormal_mineral_homeostasis	0.81493967
74	MP0002132_abnormal_respiratory_system	0.81304232
75	MP0000490_abnormal_crypts_of	0.81131746
76	MP0001819_abnormal_immune_cell	0.79727064
77	MP0002420_abnormal_adaptive_immunity	0.79303581
78	MP0005266_abnormal_metabolism	0.77480124
79	MP0001440_abnormal_grooming_behavior	0.77024664
80	MP0001873_stomach_inflammation	0.76157241
81	MP0003123_paternal_imprinting	0.75887882
82	MP0001845_abnormal_inflammatory_respons	0.75507878
83	MP0001790_abnormal_immune_system	0.75419231
84	MP0005387_immune_system_phenotype	0.75419231
85	MP0000631_abnormal_neuroendocrine_gland	0.75147778
86	MP0000538_abnormal_urinary_bladder	0.73846435
87	MP0008872_abnormal_physiological_respon	0.73568227
88	MP0003137_abnormal_impulse_conducting	0.71233070
89	MP0005501_abnormal_skin_physiology	0.70025256
90	MP0003937_abnormal_limbs/digits/tail_de	0.68522762
91	MP0002932_abnormal_joint_morphology	0.68075336
92	MP0009046_muscle_twitch	0.66502361
93	MP0001293_anophthalmia	0.66458369
94	MP0001188_hyperpigmentation	0.66434076
95	MP0000716_abnormal_immune_system	0.66222838
96	MP0000343_altered_response_to	0.65469363
97	MP0009765_abnormal_xenobiotic_induced	0.64237864
98	MP0002166_altered_tumor_susceptibility	0.63515510
99	MP0002398_abnormal_bone_marrow	0.62319675
100	MP0005025_abnormal_response_to	0.62043213

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	5.98232699
2	Decreased activity of mitochondrial respiratory chain (HP:0008972)	5.98232699
3	3-Methylglutaconic aciduria (HP:0003535)	5.83184117
4	Macrocytic anemia (HP:0001972)	5.81190139
5	Acute necrotizing encephalopathy (HP:0006965)	5.71377939
6	Abnormal mitochondria in muscle tissue (HP:0008316)	5.32597531
7	Abnormality of cells of the erythroid lineage (HP:0012130)	5.26620983
8	Mitochondrial inheritance (HP:0001427)	4.89095579
9	Abnormal number of erythroid precursors (HP:0012131)	4.82921579
10	Progressive macrocephaly (HP:0004481)	4.71833707
11	Acute encephalopathy (HP:0006846)	4.59471922
12	Increased hepatocellular lipid droplets (HP:0006565)	4.47812846
13	Increased CSF lactate (HP:0002490)	4.39008266
14	Aplastic anemia (HP:0001915)	4.27124595
15	Pallor (HP:0000980)	4.13114998
16	Lipid accumulation in hepatocytes (HP:0006561)	3.98154592
17	Increased intramyocellular lipid droplets (HP:0012240)	3.95841655
18	Hepatic necrosis (HP:0002605)	3.84693030
19	Hepatocellular necrosis (HP:0001404)	3.73974746
20	Renal Fanconi syndrome (HP:0001994)	3.67848369
21	Reticulocytopenia (HP:0001896)	3.58495084
22	Cerebral edema (HP:0002181)	3.54828204
23	Exertional dyspnea (HP:0002875)	3.44618686
24	Increased muscle lipid content (HP:0009058)	3.36880429
25	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.35237086
26	Congenital, generalized hypertrichosis (HP:0004540)	3.31995006
27	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.22835070
28	Increased serum lactate (HP:0002151)	3.18284818
29	Methylmalonic acidemia (HP:0002912)	3.07105384
30	Exercise intolerance (HP:0003546)	3.03837929
31	Lactic acidosis (HP:0003128)	2.98944822
32	Respiratory failure (HP:0002878)	2.94484715
33	Oral leukoplakia (HP:0002745)	2.91765642
34	Abnormality of alanine metabolism (HP:0010916)	2.83373420
35	Hyperalaninemia (HP:0003348)	2.83373420
36	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.83373420
37	Leukodystrophy (HP:0002415)	2.81483405
38	Respiratory difficulties (HP:0002880)	2.80716253
39	Methylmalonic aciduria (HP:0012120)	2.62041478
40	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.61251959
41	Generalized aminoaciduria (HP:0002909)	2.59101664
42	Radial bowing (HP:0002986)	2.58175002
43	Megaloblastic anemia (HP:0001889)	2.56155331
44	Type I transferrin isoform profile (HP:0003642)	2.55281326
45	Abnormality of renal resorption (HP:0011038)	2.49962292
46	Abnormality of urine glucose concentration (HP:0011016)	2.49024085
47	Glycosuria (HP:0003076)	2.49024085
48	Cleft eyelid (HP:0000625)	2.46876447
49	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.39945088
50	Hypoplasia of the radius (HP:0002984)	2.35465304
51	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.30331636
52	Abnormality of the middle phalanges of the toes (HP:0010183)	2.27671891
53	Abnormality of serum amino acid levels (HP:0003112)	2.27353247
54	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.24091372
55	Abnormality of methionine metabolism (HP:0010901)	2.22279926
56	Microretrognathia (HP:0000308)	2.20560731
57	Lethargy (HP:0001254)	2.19568676
58	Fibular aplasia (HP:0002990)	2.19014047
59	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.16737843
60	Stenosis of the external auditory canal (HP:0000402)	2.15811662
61	Aplasia/hypoplasia of the uterus (HP:0008684)	2.13725696
62	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.13279611
63	Sparse eyelashes (HP:0000653)	2.11909570
64	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.11767592
65	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.08162189
66	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.07068419
67	Testicular atrophy (HP:0000029)	2.05603764
68	Reduced antithrombin III activity (HP:0001976)	2.04275979
69	Optic disc pallor (HP:0000543)	2.02626966
70	Short middle phalanx of the 5th finger (HP:0004220)	1.96706853
71	Increased serum pyruvate (HP:0003542)	1.94640319
72	Pancytopenia (HP:0001876)	1.93000561
73	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.92238451
74	Hyperphosphaturia (HP:0003109)	1.88622247
75	Dicarboxylic aciduria (HP:0003215)	1.86590559
76	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.86590559
77	IgG deficiency (HP:0004315)	1.86534739
78	Sensory axonal neuropathy (HP:0003390)	1.83907484
79	Abnormality of vitamin B metabolism (HP:0004340)	1.81907558
80	Palpitations (HP:0001962)	1.76891923
81	Abnormal protein glycosylation (HP:0012346)	1.76610047
82	Abnormal glycosylation (HP:0012345)	1.76610047
83	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.76610047
84	Abnormal protein N-linked glycosylation (HP:0012347)	1.76610047
85	Abnormality of the fetal cardiovascular system (HP:0010948)	1.75838450
86	Abnormal umbilical cord blood vessels (HP:0011403)	1.75838450
87	Single umbilical artery (HP:0001195)	1.75838450
88	Nausea (HP:0002018)	1.73924070
89	Woolly hair (HP:0002224)	1.70837444
90	Neoplasm of head and neck (HP:0012288)	1.70256086
91	Esophageal neoplasm (HP:0100751)	1.70256086
92	Amniotic constriction ring (HP:0009775)	1.69689143
93	Abnormality of placental membranes (HP:0011409)	1.69689143
94	Abnormality of the anterior horn cell (HP:0006802)	1.66925918
95	Degeneration of anterior horn cells (HP:0002398)	1.66925918
96	Abnormality of glycolysis (HP:0004366)	1.66757552
97	Triphalangeal thumb (HP:0001199)	1.66709397
98	CNS demyelination (HP:0007305)	1.66488685
99	IgM deficiency (HP:0002850)	1.66107606
100	Depressed nasal ridge (HP:0000457)	1.64906487

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	5.80317520
2	BUB1	5.18964542
3	STK16	4.29431718
4	NME2	3.73119206
5	EIF2AK1	3.56142195
6	SRPK1	2.81125150
7	VRK2	2.66855898
8	MST4	2.26444645
9	VRK1	2.23090588
10	ZAK	2.19326859
11	CDC7	2.00549346
12	TESK2	1.84089071
13	PDK2	1.74509428
14	PLK4	1.69877388
15	RPS6KB2	1.65794111
16	NEK1	1.59529298
17	PASK	1.52912056
18	NME1	1.45708467
19	MAP3K12	1.37723627
20	EIF2AK3	1.35335415
21	PIM2	1.31354587
22	RPS6KA5	1.29199039
23	BMPR1B	1.27550258
24	ILK	1.27169005
25	AURKB	1.23155176
26	CCNB1	1.19237220
27	MAP4K2	1.17921314
28	NUAK1	1.16490633
29	MYLK	1.09361309
30	ADRBK2	1.07304888
31	ABL2	1.02970362
32	ARAF	0.99843602
33	CSNK2A2	0.98199497
34	DAPK3	0.97192696
35	AURKA	0.95823487
36	IRAK3	0.95547122
37	SCYL2	0.94790615
38	IKBKB	0.94562644
39	PLK1	0.91302272
40	TTK	0.89983031
41	CSNK2A1	0.87160491
42	BMPR2	0.85325943
43	GRK7	0.80266138
44	GRK1	0.80168821
45	BCKDK	0.78344929
46	CDK8	0.76088915
47	RIPK4	0.73908970
48	PHKG2	0.72025660
49	PHKG1	0.72025660
50	TXK	0.70888651
51	MAP2K2	0.68831577
52	RPS6KA4	0.67345776
53	INSRR	0.66996891
54	MAP3K4	0.64651208
55	CHEK2	0.63024375
56	PLK3	0.61505156
57	MKNK1	0.60691517
58	MKNK2	0.58943556
59	PIM1	0.57321584
60	EIF2AK2	0.57235402
61	STK24	0.56013613
62	CDK3	0.53886174
63	ATR	0.53340154
64	PAK4	0.52103285
65	DYRK2	0.51094249
66	TEC	0.50754455
67	CHEK1	0.50450794
68	RPS6KA6	0.48863370
69	STK10	0.48393397
70	MARK3	0.47919675
71	BRSK2	0.47094036
72	TNK2	0.46435594
73	IRAK4	0.45906170
74	STK4	0.45204100
75	WEE1	0.44334986
76	LIMK1	0.44086849
77	CDK7	0.43545005
78	TAF1	0.42876132
79	CDK4	0.41799795
80	CLK1	0.41701712
81	TESK1	0.40496253
82	MAP2K7	0.38113986
83	TGFBR1	0.38103520
84	TAOK3	0.37856572
85	CSNK1E	0.37296847
86	LYN	0.36360919
87	RPS6KL1	0.36354981
88	RPS6KC1	0.36354981
89	CSNK1G3	0.35838728
90	MUSK	0.34903100
91	ATM	0.34034275
92	PBK	0.33905383
93	TIE1	0.33677193
94	MAPK15	0.32138465
95	PAK2	0.31956826
96	GRK6	0.31916549
97	CDK19	0.31202173
98	CDK9	0.31080476
99	NEK9	0.30797349
100	ADRBK1	0.30204263

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Ribosome_Homo sapiens_hsa03010	7.65591885
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.60561005
3	Parkinsons disease_Homo sapiens_hsa05012	3.69955881
4	Proteasome_Homo sapiens_hsa03050	3.29488355
5	Protein export_Homo sapiens_hsa03060	3.04619124
6	Huntingtons disease_Homo sapiens_hsa05016	2.61322024
7	RNA polymerase_Homo sapiens_hsa03020	2.57592593
8	Alzheimers disease_Homo sapiens_hsa05010	2.52204053
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.44961136
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.35373984
11	DNA replication_Homo sapiens_hsa03030	2.22690216
12	Asthma_Homo sapiens_hsa05310	2.03070669
13	One carbon pool by folate_Homo sapiens_hsa00670	2.01090101
14	Homologous recombination_Homo sapiens_hsa03440	2.01004664
15	Nucleotide excision repair_Homo sapiens_hsa03420	1.99037903
16	Spliceosome_Homo sapiens_hsa03040	1.95204075
17	Mismatch repair_Homo sapiens_hsa03430	1.92550871
18	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.65277891
19	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.59971500
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.56979071
21	Pyrimidine metabolism_Homo sapiens_hsa00240	1.56159232
22	Allograft rejection_Homo sapiens_hsa05330	1.55617361
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.53398763
24	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.47328405
25	Graft-versus-host disease_Homo sapiens_hsa05332	1.41927703
26	Basal transcription factors_Homo sapiens_hsa03022	1.36654343
27	RNA degradation_Homo sapiens_hsa03018	1.30442735
28	RNA transport_Homo sapiens_hsa03013	1.26833391
29	Type I diabetes mellitus_Homo sapiens_hsa04940	1.25774660
30	Folate biosynthesis_Homo sapiens_hsa00790	1.24619519
31	Sulfur relay system_Homo sapiens_hsa04122	1.21957027
32	Base excision repair_Homo sapiens_hsa03410	1.20924252
33	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.20030870
34	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.93481089
35	Rheumatoid arthritis_Homo sapiens_hsa05323	0.92409196
36	Purine metabolism_Homo sapiens_hsa00230	0.92054125
37	Fanconi anemia pathway_Homo sapiens_hsa03460	0.89187059
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.88523839
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.78112441
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.77930311
41	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76758903
42	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.75595847
43	Viral myocarditis_Homo sapiens_hsa05416	0.74515812
44	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.74346302
45	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74302436
46	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.73929812
47	Caffeine metabolism_Homo sapiens_hsa00232	0.72920864
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72658544
49	Regulation of autophagy_Homo sapiens_hsa04140	0.70910880
50	Antigen processing and presentation_Homo sapiens_hsa04612	0.69468570
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69417078
52	Sulfur metabolism_Homo sapiens_hsa00920	0.66044922
53	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.62526813
54	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.59693319
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57526822
56	Primary immunodeficiency_Homo sapiens_hsa05340	0.56073741
57	Metabolic pathways_Homo sapiens_hsa01100	0.55824101
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54859510
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.54679536
60	Mineral absorption_Homo sapiens_hsa04978	0.53477718
61	Glutathione metabolism_Homo sapiens_hsa00480	0.52495457
62	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.51370909
63	Retinol metabolism_Homo sapiens_hsa00830	0.46583278
64	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.42379420
65	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.41007219
66	Alcoholism_Homo sapiens_hsa05034	0.40258756
67	Cell cycle_Homo sapiens_hsa04110	0.39163197
68	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.37956774
69	Tryptophan metabolism_Homo sapiens_hsa00380	0.34267838
70	Leishmaniasis_Homo sapiens_hsa05140	0.34027245
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.34026863
72	Herpes simplex infection_Homo sapiens_hsa05168	0.33697504
73	Tyrosine metabolism_Homo sapiens_hsa00350	0.33068942
74	Pyruvate metabolism_Homo sapiens_hsa00620	0.33062536
75	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.32666154
76	Non-homologous end-joining_Homo sapiens_hsa03450	0.30897072
77	p53 signaling pathway_Homo sapiens_hsa04115	0.29320286
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.27274294
79	Legionellosis_Homo sapiens_hsa05134	0.27255155
80	Linoleic acid metabolism_Homo sapiens_hsa00591	0.22842028
81	Phototransduction_Homo sapiens_hsa04744	0.19941432
82	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.19579990
83	Propanoate metabolism_Homo sapiens_hsa00640	0.17034941
84	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.16996319
85	Peroxisome_Homo sapiens_hsa04146	0.16878152
86	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.15779123
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.14971396
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.14330471
89	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.14258647
90	Toxoplasmosis_Homo sapiens_hsa05145	0.13878086
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.13005726
92	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.12616380
93	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.08167826
94	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.08061710
95	Nitrogen metabolism_Homo sapiens_hsa00910	0.07620180
96	Phagosome_Homo sapiens_hsa04145	0.06739617
97	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.06198700
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.05978383
99	Selenocompound metabolism_Homo sapiens_hsa00450	0.05841182
100	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.04834471

RPL36A-HNRNPH2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »