ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	8.94562794
2	viral transcription (GO:0019083)	8.76837865
3	translational termination (GO:0006415)	8.43222195
4	ribosomal small subunit biogenesis (GO:0042274)	7.91749647
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.02126807
6	cotranslational protein targeting to membrane (GO:0006613)	6.96620110
7	protein targeting to ER (GO:0045047)	6.90927988
8	translational elongation (GO:0006414)	6.84290426
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.69721716
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.67817340
11	ATP synthesis coupled proton transport (GO:0015986)	6.67817340
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.62504129
13	maturation of SSU-rRNA (GO:0030490)	6.58796804
14	cellular protein complex disassembly (GO:0043624)	6.52157139
15	protein localization to endoplasmic reticulum (GO:0070972)	6.49863669
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.13216176
17	viral life cycle (GO:0019058)	6.10928146
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.08590525
19	protein complex disassembly (GO:0043241)	5.54529206
20	macromolecular complex disassembly (GO:0032984)	5.21627795
21	translational initiation (GO:0006413)	5.21456810
22	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.95033919
23	substrate-independent telencephalic tangential migration (GO:0021826)	4.95033919
24	protein targeting to membrane (GO:0006612)	4.91772763
25	respiratory electron transport chain (GO:0022904)	4.67002072
26	electron transport chain (GO:0022900)	4.64818051
27	ribosomal large subunit biogenesis (GO:0042273)	4.57160878
28	pattern specification involved in kidney development (GO:0061004)	4.44872493
29	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.24565002
30	axonemal dynein complex assembly (GO:0070286)	4.14951564
31	translation (GO:0006412)	4.13941846
32	chaperone-mediated protein transport (GO:0072321)	4.13298099
33	protein neddylation (GO:0045116)	4.06314019
34	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.00226297
35	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.97914119
36	epithelial cilium movement (GO:0003351)	3.96364216
37	ATP biosynthetic process (GO:0006754)	3.81590045
38	neuron fate determination (GO:0048664)	3.78435399
39	mRNA catabolic process (GO:0006402)	3.78285827
40	hydrogen ion transmembrane transport (GO:1902600)	3.73910212
41	tongue development (GO:0043586)	3.68092392
42	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.62214787
43	pyrimidine nucleotide catabolic process (GO:0006244)	3.59123045
44	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.56439280
45	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.56439280
46	NADH dehydrogenase complex assembly (GO:0010257)	3.56439280
47	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.53222483
48	cilium movement (GO:0003341)	3.51803513
49	regulation of cellular respiration (GO:0043457)	3.50221849
50	RNA catabolic process (GO:0006401)	3.49429043
51	auditory receptor cell differentiation (GO:0042491)	3.49286508
52	establishment of protein localization to membrane (GO:0090150)	3.41204863
53	ribonucleoprotein complex biogenesis (GO:0022613)	3.38369240
54	rRNA catabolic process (GO:0016075)	3.37523331
55	behavioral response to nicotine (GO:0035095)	3.35435161
56	proton transport (GO:0015992)	3.32798247
57	negative regulation of heart rate (GO:0010459)	3.26184479
58	hypothalamus development (GO:0021854)	3.24149983
59	hydrogen transport (GO:0006818)	3.23341873
60	cell proliferation in forebrain (GO:0021846)	3.23009751
61	protein complex biogenesis (GO:0070271)	3.22498339
62	adaptation of signaling pathway (GO:0023058)	3.18344518
63	motile cilium assembly (GO:0044458)	3.17548849
64	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.15534210
65	cellular component biogenesis (GO:0044085)	3.14661323
66	negative regulation of mast cell activation (GO:0033004)	3.14069698
67	centriole replication (GO:0007099)	3.13384435
68	ncRNA 3-end processing (GO:0043628)	3.07826585
69	protein targeting (GO:0006605)	3.07462777
70	GTP biosynthetic process (GO:0006183)	3.00859804
71	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.98473069
72	central nervous system myelination (GO:0022010)	2.91606856
73	axon ensheathment in central nervous system (GO:0032291)	2.91606856
74	segment specification (GO:0007379)	2.89042598
75	nephron tubule morphogenesis (GO:0072078)	2.88955033
76	nephron epithelium morphogenesis (GO:0072088)	2.88955033
77	regulation of microtubule-based movement (GO:0060632)	2.87466031
78	mitochondrial respiratory chain complex assembly (GO:0033108)	2.84656569
79	rRNA metabolic process (GO:0016072)	2.80460420
80	base-excision repair, AP site formation (GO:0006285)	2.79828017
81	protein localization to membrane (GO:0072657)	2.78735007
82	rRNA processing (GO:0006364)	2.69560205
83	establishment of protein localization to organelle (GO:0072594)	2.68989645
84	short-term memory (GO:0007614)	2.66690470
85	respiratory chain complex IV assembly (GO:0008535)	2.66329380
86	nonmotile primary cilium assembly (GO:0035058)	2.61945781
87	lens fiber cell development (GO:0070307)	2.60745039
88	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.58837460
89	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.58837460
90	nucleoside triphosphate biosynthetic process (GO:0009142)	2.54684598
91	pyrimidine nucleobase catabolic process (GO:0006208)	2.54326986
92	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.54323509
93	positive regulation of respiratory burst (GO:0060267)	2.54050227
94	axoneme assembly (GO:0035082)	2.53983290
95	peptidyl-threonine dephosphorylation (GO:0035970)	2.52340338
96	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.52049891
97	UTP biosynthetic process (GO:0006228)	2.51486969
98	cardiovascular system development (GO:0072358)	2.44311136
99	telencephalon development (GO:0021537)	2.42196099
100	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.41468226

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.85211948
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.88233948
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.60280226
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.03404566
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.34746510
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.33884580
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.25188440
8	VDR_22108803_ChIP-Seq_LS180_Human	2.17833883
9	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.15408517
10	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.12654290
11	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.11460977
12	IGF1R_20145208_ChIP-Seq_DFB_Human	1.96963997
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.90117053
14	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.86683280
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.82510722
16	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.78047053
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.71614130
18	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.66291085
19	TP53_22573176_ChIP-Seq_HFKS_Human	1.65832470
20	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.65654299
21	TAF2_19829295_ChIP-Seq_ESCs_Human	1.62224875
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.62202204
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.61230893
24	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.57763920
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.55511343
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54676811
27	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.53915262
28	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.49718259
29	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.45795261
30	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.43746094
31	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.43688556
32	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.43133161
33	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.42893121
34	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.42062844
35	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.41879315
36	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.41239807
37	EWS_26573619_Chip-Seq_HEK293_Human	1.40743274
38	TTF2_22483619_ChIP-Seq_HELA_Human	1.39803680
39	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.39611789
40	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.39051643
41	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.38322470
42	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.38322470
43	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.37652582
44	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.34276364
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.32403761
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.31444464
47	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.29018482
48	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.26133991
49	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.25194062
50	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.24826804
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.24764233
52	ERA_21632823_ChIP-Seq_H3396_Human	1.23951597
53	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23720033
54	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.22563409
55	GBX2_23144817_ChIP-Seq_PC3_Human	1.22557221
56	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.21046820
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.20168194
58	REST_21632747_ChIP-Seq_MESCs_Mouse	1.19670774
59	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.18578416
60	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.14619677
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13925668
62	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13157126
63	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.13157126
64	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12773283
65	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.10848351
66	NCOR_22424771_ChIP-Seq_293T_Human	1.08623172
67	VDR_23849224_ChIP-Seq_CD4+_Human	1.08373329
68	SA1_27219007_Chip-Seq_Bcells_Human	1.06451639
69	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05149855
70	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.04834298
71	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04070773
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04070773
73	FUS_26573619_Chip-Seq_HEK293_Human	1.03147456
74	STAT1_20625510_ChIP-Seq_HELA_Human	1.01104253
75	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.00730315
76	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.00689993
77	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.98577871
78	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.97671796
79	CBP_20019798_ChIP-Seq_JUKART_Human	0.97671796
80	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.96810609
81	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.94675037
82	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.93633595
83	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.93485817
84	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.92811735
85	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91066750
86	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.90961717
87	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90641934
88	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90641934
89	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.89977953
90	BCL6_27268052_Chip-Seq_Bcells_Human	0.89898361
91	P300_19829295_ChIP-Seq_ESCs_Human	0.87332358
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.87012392
93	ERG_20517297_ChIP-Seq_VCAP_Human	0.86718837
94	CTCF_27219007_Chip-Seq_Bcells_Human	0.86518037
95	P53_21459846_ChIP-Seq_SAOS-2_Human	0.83318107
96	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.83175217
97	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.82972409
98	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.82777552
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.82628282
100	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.82119398

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.77651532
2	MP0006292_abnormal_olfactory_placode	4.47578691
3	MP0004142_abnormal_muscle_tone	2.73096888
4	MP0003122_maternal_imprinting	2.48256832
5	MP0003787_abnormal_imprinting	2.24899772
6	MP0008789_abnormal_olfactory_epithelium	2.15172946
7	MP0003123_paternal_imprinting	2.14436932
8	MP0008877_abnormal_DNA_methylation	2.09476995
9	MP0003646_muscle_fatigue	2.06411148
10	MP0001348_abnormal_lacrimal_gland	2.05248209
11	MP0005377_hearing/vestibular/ear_phenot	2.02109781
12	MP0003878_abnormal_ear_physiology	2.02109781
13	MP0002653_abnormal_ependyma_morphology	1.98812202
14	MP0005394_taste/olfaction_phenotype	1.89755083
15	MP0005499_abnormal_olfactory_system	1.89755083
16	MP0004885_abnormal_endolymph	1.86314889
17	MP0003121_genomic_imprinting	1.83116675
18	MP0010030_abnormal_orbit_morphology	1.82606673
19	MP0000049_abnormal_middle_ear	1.80302102
20	MP0001293_anophthalmia	1.72008059
21	MP0004742_abnormal_vestibular_system	1.69851265
22	MP0002876_abnormal_thyroid_physiology	1.65239638
23	MP0002272_abnormal_nervous_system	1.59567041
24	MP0006276_abnormal_autonomic_nervous	1.59439276
25	MP0000778_abnormal_nervous_system	1.59007142
26	MP0001970_abnormal_pain_threshold	1.58573007
27	MP0001986_abnormal_taste_sensitivity	1.57770835
28	MP0003880_abnormal_central_pattern	1.54162217
29	MP0002638_abnormal_pupillary_reflex	1.50248795
30	MP0005551_abnormal_eye_electrophysiolog	1.48298864
31	MP0008872_abnormal_physiological_respon	1.46666359
32	MP0006072_abnormal_retinal_apoptosis	1.44626153
33	MP0005408_hypopigmentation	1.43447494
34	MP0002733_abnormal_thermal_nociception	1.40531570
35	MP0004145_abnormal_muscle_electrophysio	1.40457566
36	MP0002234_abnormal_pharynx_morphology	1.39018604
37	MP0008875_abnormal_xenobiotic_pharmacok	1.37476114
38	MP0004133_heterotaxia	1.37371516
39	MP0001835_abnormal_antigen_presentation	1.34701686
40	MP0002822_catalepsy	1.27970621
41	MP0002102_abnormal_ear_morphology	1.27247314
42	MP0002837_dystrophic_cardiac_calcinosis	1.26865414
43	MP0008995_early_reproductive_senescence	1.26420564
44	MP0009046_muscle_twitch	1.24863401
45	MP0009764_decreased_sensitivity_to	1.23908523
46	MP0001905_abnormal_dopamine_level	1.23203969
47	MP0001486_abnormal_startle_reflex	1.22423919
48	MP0003879_abnormal_hair_cell	1.21826758
49	MP0002735_abnormal_chemical_nociception	1.21245449
50	MP0000026_abnormal_inner_ear	1.19771370
51	MP0002938_white_spotting	1.19549271
52	MP0001502_abnormal_circadian_rhythm	1.19323434
53	MP0002095_abnormal_skin_pigmentation	1.19217015
54	MP0000516_abnormal_urinary_system	1.18730275
55	MP0005367_renal/urinary_system_phenotyp	1.18730275
56	MP0005253_abnormal_eye_physiology	1.17891577
57	MP0009745_abnormal_behavioral_response	1.16996116
58	MP0003786_premature_aging	1.16633139
59	MP0003136_yellow_coat_color	1.15422305
60	MP0001440_abnormal_grooming_behavior	1.14204517
61	MP0002184_abnormal_innervation	1.11466789
62	MP0005195_abnormal_posterior_eye	1.11048433
63	MP0001968_abnormal_touch/_nociception	1.09690721
64	MP0001485_abnormal_pinna_reflex	1.09610752
65	MP0005174_abnormal_tail_pigmentation	1.08911406
66	MP0005671_abnormal_response_to	1.06192008
67	MP0002557_abnormal_social/conspecific_i	1.03855211
68	MP0005423_abnormal_somatic_nervous	1.02038032
69	MP0002572_abnormal_emotion/affect_behav	1.01464650
70	MP0002233_abnormal_nose_morphology	1.00929997
71	MP0005391_vision/eye_phenotype	0.98528007
72	MP0004043_abnormal_pH_regulation	0.97420852
73	MP0001529_abnormal_vocalization	0.96789484
74	MP0005075_abnormal_melanosome_morpholog	0.94746553
75	MP0002752_abnormal_somatic_nervous	0.93381285
76	MP0000631_abnormal_neuroendocrine_gland	0.92833737
77	MP0003938_abnormal_ear_development	0.92190887
78	MP0001963_abnormal_hearing_physiology	0.91879536
79	MP0003937_abnormal_limbs/digits/tail_de	0.91765293
80	MP0001919_abnormal_reproductive_system	0.89839266
81	MP0002734_abnormal_mechanical_nocicepti	0.89323083
82	MP0002064_seizures	0.87145350
83	MP0002163_abnormal_gland_morphology	0.86967816
84	MP0002063_abnormal_learning/memory/cond	0.86146128
85	MP0001984_abnormal_olfaction	0.86023848
86	MP0003635_abnormal_synaptic_transmissio	0.85140074
87	MP0005389_reproductive_system_phenotype	0.82851172
88	MP0003186_abnormal_redox_activity	0.79920481
89	MP0002249_abnormal_larynx_morphology	0.75789620
90	MP0000427_abnormal_hair_cycle	0.74975913
91	MP0005085_abnormal_gallbladder_physiolo	0.73730029
92	MP0001324_abnormal_eye_pigmentation	0.72582477
93	MP0006036_abnormal_mitochondrial_physio	0.71162123
94	MP0003755_abnormal_palate_morphology	0.69548314
95	MP0000534_abnormal_ureter_morphology	0.67912252
96	MP0002736_abnormal_nociception_after	0.67386808
97	MP0002090_abnormal_vision	0.66891000
98	MP0004859_abnormal_synaptic_plasticity	0.66340938
99	MP0008007_abnormal_cellular_replicative	0.65663632
100	MP0002067_abnormal_sensory_capabilities	0.65465633

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.38630717
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.59157768
3	Acute necrotizing encephalopathy (HP:0006965)	4.40004607
4	Abnormality of midbrain morphology (HP:0002418)	4.10448994
5	Molar tooth sign on MRI (HP:0002419)	4.10448994
6	Macrocytic anemia (HP:0001972)	4.01270734
7	Septo-optic dysplasia (HP:0100842)	3.99423329
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.77761196
9	Mitochondrial inheritance (HP:0001427)	3.66136739
10	Progressive macrocephaly (HP:0004481)	3.63298215
11	Hepatocellular necrosis (HP:0001404)	3.60192606
12	Acute encephalopathy (HP:0006846)	3.58080561
13	Abnormal ciliary motility (HP:0012262)	3.51301751
14	Pancreatic fibrosis (HP:0100732)	3.33365171
15	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.22643847
16	Absent/shortened dynein arms (HP:0200106)	3.22643847
17	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.19378896
18	Hepatic necrosis (HP:0002605)	3.16819311
19	Pancreatic cysts (HP:0001737)	3.11988727
20	Pallor (HP:0000980)	3.11757113
21	Increased CSF lactate (HP:0002490)	3.07210164
22	Stenosis of the external auditory canal (HP:0000402)	3.02397364
23	Abnormal respiratory motile cilium physiology (HP:0012261)	3.01024588
24	Abnormal number of erythroid precursors (HP:0012131)	2.99271042
25	Abnormal respiratory motile cilium morphology (HP:0005938)	2.96869814
26	Abnormal respiratory epithelium morphology (HP:0012253)	2.96869814
27	Supernumerary spleens (HP:0009799)	2.73762226
28	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.61921616
29	Myokymia (HP:0002411)	2.59523494
30	Rib fusion (HP:0000902)	2.57905718
31	Optic disc pallor (HP:0000543)	2.56580888
32	Absent septum pellucidum (HP:0001331)	2.54769879
33	Increased hepatocellular lipid droplets (HP:0006565)	2.51259129
34	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.48016230
35	Lipid accumulation in hepatocytes (HP:0006561)	2.47718725
36	Cerebral edema (HP:0002181)	2.44299948
37	Asplenia (HP:0001746)	2.43075294
38	Congenital stationary night blindness (HP:0007642)	2.39118724
39	Cystic liver disease (HP:0006706)	2.37970728
40	Medial flaring of the eyebrow (HP:0010747)	2.32888065
41	Abnormal hemoglobin (HP:0011902)	2.32265216
42	Sclerocornea (HP:0000647)	2.31198919
43	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.29803011
44	Bifid tongue (HP:0010297)	2.29770627
45	11 pairs of ribs (HP:0000878)	2.28594428
46	Failure to thrive in infancy (HP:0001531)	2.28309689
47	Pendular nystagmus (HP:0012043)	2.27437492
48	Hypoplasia of the ulna (HP:0003022)	2.25953862
49	Anophthalmia (HP:0000528)	2.23181828
50	Depressed nasal ridge (HP:0000457)	2.20600348
51	Abnormal drinking behavior (HP:0030082)	2.20055621
52	Polydipsia (HP:0001959)	2.20055621
53	Renal Fanconi syndrome (HP:0001994)	2.18317639
54	Abnormality of the renal cortex (HP:0011035)	2.16078150
55	Microretrognathia (HP:0000308)	2.04770124
56	Leukodystrophy (HP:0002415)	2.04137741
57	Synostosis of carpal bones (HP:0005048)	2.03932637
58	Absent thumb (HP:0009777)	2.01760581
59	Abnormality of the septum pellucidum (HP:0007375)	2.01136079
60	Congenital, generalized hypertrichosis (HP:0004540)	2.00336886
61	Chronic bronchitis (HP:0004469)	1.99002122
62	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.95025929
63	Polyphagia (HP:0002591)	1.94821703
64	Median cleft lip (HP:0000161)	1.94551754
65	True hermaphroditism (HP:0010459)	1.93567576
66	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.93141172
67	Maternal diabetes (HP:0009800)	1.92106046
68	Abnormal rod and cone electroretinograms (HP:0008323)	1.91632043
69	3-Methylglutaconic aciduria (HP:0003535)	1.91197785
70	Hip dysplasia (HP:0001385)	1.90741643
71	Postaxial foot polydactyly (HP:0001830)	1.90364968
72	Abnormality of the renal medulla (HP:0100957)	1.90001515
73	Tubular atrophy (HP:0000092)	1.89789567
74	Abnormality of the labia minora (HP:0012880)	1.88441561
75	Pachygyria (HP:0001302)	1.88321153
76	Gait imbalance (HP:0002141)	1.87353809
77	Polyuria (HP:0000103)	1.87104892
78	Missing ribs (HP:0000921)	1.84484365
79	Hypoplasia of the radius (HP:0002984)	1.84473404
80	Agitation (HP:0000713)	1.84472530
81	Increased intramyocellular lipid droplets (HP:0012240)	1.84092487
82	Oligodactyly (hands) (HP:0001180)	1.83793533
83	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.82985720
84	Congenital hepatic fibrosis (HP:0002612)	1.81268455
85	Nephronophthisis (HP:0000090)	1.80439184
86	Forearm undergrowth (HP:0009821)	1.79686557
87	Respiratory failure (HP:0002878)	1.79050472
88	Flat capital femoral epiphysis (HP:0003370)	1.78739849
89	Growth hormone deficiency (HP:0000824)	1.77154380
90	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.75469805
91	Exertional dyspnea (HP:0002875)	1.75329703
92	Hyperthyroidism (HP:0000836)	1.74497242
93	Facial hemangioma (HP:0000329)	1.74433996
94	Papilledema (HP:0001085)	1.72913595
95	Abnormality of magnesium homeostasis (HP:0004921)	1.72860981
96	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.71425588
97	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.70890936
98	Lactic acidosis (HP:0003128)	1.69619070
99	Congenital primary aphakia (HP:0007707)	1.68656224
100	Abnormal eating behavior (HP:0100738)	1.68192792

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	4.88466443
2	MAP3K12	4.67030666
3	BMPR2	3.29615889
4	WNK4	3.21320867
5	NUAK1	3.20143004
6	STK16	2.41891550
7	MYLK	2.32841203
8	DYRK2	2.18460640
9	LRRK2	2.14920811
10	OXSR1	1.91111600
11	WNK1	1.77243464
12	GRK1	1.72628323
13	TAOK3	1.64189259
14	PIK3CA	1.63184709
15	ADRBK2	1.62334969
16	PNCK	1.60150906
17	DAPK3	1.60045800
18	TIE1	1.58073619
19	EPHB2	1.51281882
20	MAP4K2	1.49471902
21	BCKDK	1.49339533
22	TXK	1.36609179
23	MAP2K7	1.34865361
24	CDC7	1.32729075
25	CSF1R	1.30875336
26	TLK1	1.20752506
27	PINK1	1.17721213
28	NME2	1.12817790
29	ILK	1.10965791
30	ZAK	1.07439467
31	FLT3	1.03310178
32	STK11	1.02590443
33	MINK1	0.99426152
34	NME1	0.96059051
35	CAMK1	0.96007135
36	FRK	0.95913542
37	ERBB3	0.91162323
38	MAP4K1	0.86758186
39	MARK3	0.84746040
40	MARK1	0.82314554
41	WNK3	0.81887969
42	PRKCG	0.79204555
43	PRKCH	0.78979050
44	MAPK13	0.78402915
45	INSRR	0.77661505
46	PRKCI	0.77355490
47	CAMK2D	0.76110572
48	PAK3	0.76064426
49	AURKA	0.72420783
50	CASK	0.68030196
51	PRKACA	0.67859197
52	CAMKK2	0.66856944
53	AURKB	0.66007741
54	STK39	0.65380211
55	KIT	0.64543503
56	ROCK1	0.63849961
57	BMPR1B	0.63405041
58	ADRBK1	0.62979835
59	PHKG2	0.62785306
60	PHKG1	0.62785306
61	IKBKB	0.62524887
62	OBSCN	0.62116366
63	CAMKK1	0.61935544
64	LATS1	0.60724252
65	NTRK2	0.59803155
66	BTK	0.59689202
67	MAP2K2	0.59501067
68	BRSK1	0.59153544
69	CSNK1E	0.59032171
70	RPS6KA6	0.58076745
71	CSNK2A2	0.58055591
72	BRSK2	0.57003873
73	MAP2K4	0.56436969
74	MAPK15	0.55260310
75	MAP3K4	0.55128033
76	CDK14	0.54659462
77	CAMK1G	0.53901126
78	PRKCE	0.53663509
79	PIM2	0.51921123
80	PRKCA	0.48249331
81	PKN1	0.47644340
82	DAPK2	0.45306837
83	PIM1	0.45271280
84	CDK11A	0.45083654
85	DAPK1	0.44416669
86	MARK2	0.43597919
87	CDK8	0.43590559
88	PRKCD	0.43335699
89	CSNK1G2	0.42250866
90	ABL2	0.41767373
91	CAMK2A	0.39404058
92	EPHA4	0.39076501
93	RPS6KA3	0.39014480
94	PRKG1	0.38355558
95	DMPK	0.37465940
96	SGK1	0.37075013
97	PRKAA2	0.36951424
98	PRKCZ	0.36908974
99	CSNK1G3	0.36547199
100	KDR	0.36436089

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.66388268
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.60438190
3	Asthma_Homo sapiens_hsa05310	4.02826188
4	Parkinsons disease_Homo sapiens_hsa05012	3.69510363
5	Cardiac muscle contraction_Homo sapiens_hsa04260	3.49551747
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.84113818
7	Huntingtons disease_Homo sapiens_hsa05016	2.71239880
8	Alzheimers disease_Homo sapiens_hsa05010	2.69210310
9	Allograft rejection_Homo sapiens_hsa05330	2.61154336
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.53831055
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.47333739
12	Graft-versus-host disease_Homo sapiens_hsa05332	2.12985153
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.94325215
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.81577223
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.68732823
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.53803771
17	RNA polymerase_Homo sapiens_hsa03020	1.41411189
18	Proteasome_Homo sapiens_hsa03050	1.39076475
19	Protein export_Homo sapiens_hsa03060	1.35513637
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.29399715
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.27004311
22	Viral myocarditis_Homo sapiens_hsa05416	1.26803582
23	Homologous recombination_Homo sapiens_hsa03440	1.19620425
24	Phototransduction_Homo sapiens_hsa04744	1.15693223
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.14802476
26	Nicotine addiction_Homo sapiens_hsa05033	1.14241224
27	Rheumatoid arthritis_Homo sapiens_hsa05323	1.13410740
28	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.13043477
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.09931669
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.00638067
31	Antigen processing and presentation_Homo sapiens_hsa04612	0.97509395
32	Basal transcription factors_Homo sapiens_hsa03022	0.96923916
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.94844437
34	RNA degradation_Homo sapiens_hsa03018	0.93681135
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.90271926
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.85261772
37	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.82605953
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.81378281
39	Peroxisome_Homo sapiens_hsa04146	0.80065176
40	Fat digestion and absorption_Homo sapiens_hsa04975	0.79761074
41	Tryptophan metabolism_Homo sapiens_hsa00380	0.75729016
42	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75719284
43	Caffeine metabolism_Homo sapiens_hsa00232	0.75311741
44	Olfactory transduction_Homo sapiens_hsa04740	0.75302122
45	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69826533
46	Propanoate metabolism_Homo sapiens_hsa00640	0.67555346
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.65181773
48	Nucleotide excision repair_Homo sapiens_hsa03420	0.64059628
49	Regulation of autophagy_Homo sapiens_hsa04140	0.63121263
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.61359012
51	One carbon pool by folate_Homo sapiens_hsa00670	0.61199563
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.59926483
53	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.58565889
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.57699323
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56673770
56	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.54647435
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53991229
58	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51032132
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50914658
60	Primary immunodeficiency_Homo sapiens_hsa05340	0.50524516
61	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.49171511
62	Morphine addiction_Homo sapiens_hsa05032	0.49087156
63	Basal cell carcinoma_Homo sapiens_hsa05217	0.48469589
64	Metabolic pathways_Homo sapiens_hsa01100	0.45791386
65	Insulin secretion_Homo sapiens_hsa04911	0.45697906
66	Salivary secretion_Homo sapiens_hsa04970	0.44830004
67	Leishmaniasis_Homo sapiens_hsa05140	0.44529898
68	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.38644141
69	Butanoate metabolism_Homo sapiens_hsa00650	0.38318880
70	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.35633417
71	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.32899758
72	Retinol metabolism_Homo sapiens_hsa00830	0.32103566
73	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.29355100
74	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.29136966
75	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.28771413
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.27569358
77	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.26946860
78	GABAergic synapse_Homo sapiens_hsa04727	0.26731856
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.26098177
80	Taste transduction_Homo sapiens_hsa04742	0.25898423
81	Purine metabolism_Homo sapiens_hsa00230	0.25738118
82	Gastric acid secretion_Homo sapiens_hsa04971	0.25267593
83	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.24800525
84	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.24493140
85	Pancreatic secretion_Homo sapiens_hsa04972	0.22996089
86	Phagosome_Homo sapiens_hsa04145	0.21892229
87	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.21460951
88	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.20493192
89	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.19282449
90	African trypanosomiasis_Homo sapiens_hsa05143	0.19045956
91	Axon guidance_Homo sapiens_hsa04360	0.18933176
92	Circadian entrainment_Homo sapiens_hsa04713	0.18893497
93	Glutamatergic synapse_Homo sapiens_hsa04724	0.17314686
94	Serotonergic synapse_Homo sapiens_hsa04726	0.16682100
95	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.16450289
96	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.13658338
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.13334048
98	Fatty acid degradation_Homo sapiens_hsa00071	0.13071080
99	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.12190503
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.11817075

RPL36AP10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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