ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	translational termination (GO:0006415)	9.83898878
2	ribosomal small subunit biogenesis (GO:0042274)	9.81413768
3	ribosomal small subunit assembly (GO:0000028)	8.60296891
4	translational elongation (GO:0006414)	8.27486618
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	8.17754025
6	cotranslational protein targeting to membrane (GO:0006613)	8.05297665
7	protein targeting to ER (GO:0045047)	8.01433483
8	establishment of protein localization to endoplasmic reticulum (GO:0072599)	7.67343640
9	viral life cycle (GO:0019058)	7.51909434
10	cellular protein complex disassembly (GO:0043624)	7.50952855
11	protein localization to endoplasmic reticulum (GO:0070972)	7.50901248
12	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	7.20429729
13	maturation of SSU-rRNA (GO:0030490)	6.94162119
14	ATP synthesis coupled proton transport (GO:0015986)	6.47562726
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.47562726
16	protein complex disassembly (GO:0043241)	6.41230335
17	translational initiation (GO:0006413)	6.32410231
18	macromolecular complex disassembly (GO:0032984)	5.97710773
19	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.64040709
20	protein targeting to membrane (GO:0006612)	5.45638860
21	ribosomal large subunit biogenesis (GO:0042273)	5.37842288
22	chaperone-mediated protein transport (GO:0072321)	5.21900962
23	translation (GO:0006412)	5.09885773
24	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.86090844
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.79243069
26	ribonucleoprotein complex biogenesis (GO:0022613)	4.61137321
27	mRNA catabolic process (GO:0006402)	4.56547594
28	respiratory electron transport chain (GO:0022904)	4.49318089
29	electron transport chain (GO:0022900)	4.44171629
30	protein complex biogenesis (GO:0070271)	4.34004029
31	cellular component biogenesis (GO:0044085)	4.32607447
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.25243244
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.25243244
34	NADH dehydrogenase complex assembly (GO:0010257)	4.25243244
35	CTP metabolic process (GO:0046036)	4.23364094
36	CTP biosynthetic process (GO:0006241)	4.23364094
37	nucleotide salvage (GO:0043173)	4.08295224
38	RNA catabolic process (GO:0006401)	4.07154525
39	mitochondrial respiratory chain complex assembly (GO:0033108)	4.05864137
40	ATP biosynthetic process (GO:0006754)	4.05492934
41	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.01504334
42	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.01504334
43	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.98754557
44	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.98069609
45	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.92003508
46	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.83820383
47	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.83732412
48	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.82398146
49	behavioral response to nicotine (GO:0035095)	3.80765978
50	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.78020316
51	protein neddylation (GO:0045116)	3.67694761
52	establishment of protein localization to membrane (GO:0090150)	3.67372109
53	respiratory chain complex IV assembly (GO:0008535)	3.65500117
54	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.56474274
55	protein targeting (GO:0006605)	3.53494011
56	GTP biosynthetic process (GO:0006183)	3.49286991
57	regulation of cellular respiration (GO:0043457)	3.41509040
58	nucleoside salvage (GO:0043174)	3.41411048
59	nucleoside triphosphate biosynthetic process (GO:0009142)	3.41062434
60	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.40668902
61	pyrimidine nucleotide catabolic process (GO:0006244)	3.40425669
62	cytochrome complex assembly (GO:0017004)	3.35609601
63	regulation of activation of Janus kinase activity (GO:0010533)	3.33649079
64	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.26041604
65	establishment of protein localization to organelle (GO:0072594)	3.24966670
66	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.20818540
67	hydrogen ion transmembrane transport (GO:1902600)	3.15571418
68	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.08651406
69	DNA deamination (GO:0045006)	3.08282648
70	UTP biosynthetic process (GO:0006228)	2.98263148
71	substrate-independent telencephalic tangential migration (GO:0021826)	2.95430665
72	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.95430665
73	protein localization to membrane (GO:0072657)	2.93739645
74	pyrimidine nucleoside salvage (GO:0043097)	2.91667579
75	pyrimidine-containing compound salvage (GO:0008655)	2.91667579
76	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.91010821
77	proton transport (GO:0015992)	2.86088883
78	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.85649497
79	rRNA metabolic process (GO:0016072)	2.85594743
80	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.85331834
81	termination of RNA polymerase III transcription (GO:0006386)	2.85331834
82	purine nucleotide salvage (GO:0032261)	2.85156880
83	protein targeting to mitochondrion (GO:0006626)	2.84913866
84	cell proliferation in forebrain (GO:0021846)	2.84082467
85	cardiovascular system development (GO:0072358)	2.80783349
86	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.79725212
87	hydrogen transport (GO:0006818)	2.78248495
88	rRNA processing (GO:0006364)	2.75824172
89	establishment of protein localization to mitochondrion (GO:0072655)	2.73336819
90	activation of MAPKKK activity (GO:0000185)	2.72946416
91	ncRNA 3-end processing (GO:0043628)	2.72318703
92	protein-cofactor linkage (GO:0018065)	2.71926348
93	peptidyl-histidine modification (GO:0018202)	2.70830850
94	UTP metabolic process (GO:0046051)	2.69090393
95	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.68080209
96	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.66098207
97	pseudouridine synthesis (GO:0001522)	2.64215630
98	UMP metabolic process (GO:0046049)	2.60898468
99	UMP biosynthetic process (GO:0006222)	2.60898468
100	viral transcription (GO:0019083)	10.3367017

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.12205630
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.11408367
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.73885370
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.04540295
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.87699584
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.73180740
7	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.53600355
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.52065235
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.50574647
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.46386240
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.22131162
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20482680
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.19829532
14	XRN2_22483619_ChIP-Seq_HELA_Human	2.07812473
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.99519590
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.93550096
17	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.91221169
18	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.89247661
19	VDR_22108803_ChIP-Seq_LS180_Human	1.87217661
20	ZNF274_21170338_ChIP-Seq_K562_Hela	1.84862789
21	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.84850727
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.83235853
23	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.81702323
24	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.78252215
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.78161962
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.77076975
27	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.73685216
28	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.65986537
29	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.64799377
30	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.63672593
31	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.63444179
32	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.62755386
33	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.61508065
34	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.59556703
35	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.58158717
36	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.57637435
37	TTF2_22483619_ChIP-Seq_HELA_Human	1.57449040
38	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.51309203
39	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.49092403
40	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.47880891
41	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.46838954
42	TAF2_19829295_ChIP-Seq_ESCs_Human	1.41428255
43	FOXP3_21729870_ChIP-Seq_TREG_Human	1.39364686
44	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.37336356
45	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.37010454
46	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.35709142
47	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.34573193
48	VDR_23849224_ChIP-Seq_CD4+_Human	1.34317308
49	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.34149628
50	BCL6_27268052_Chip-Seq_Bcells_Human	1.32628704
51	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.30268201
52	MYC_18940864_ChIP-ChIP_HL60_Human	1.30168514
53	CTCF_20526341_ChIP-Seq_ESCs_Human	1.29850134
54	SA1_27219007_Chip-Seq_Bcells_Human	1.29668933
55	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.29451048
56	P68_20966046_ChIP-Seq_HELA_Human	1.29385657
57	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.29289593
58	GABP_19822575_ChIP-Seq_HepG2_Human	1.27743048
59	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27107161
60	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.25339034
61	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.21522987
62	NANOG_20526341_ChIP-Seq_ESCs_Human	1.20618265
63	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.20488145
64	ERA_21632823_ChIP-Seq_H3396_Human	1.20334879
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.19605870
66	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.18644600
67	E2F1_20622854_ChIP-Seq_HELA_Human	1.18553179
68	IRF1_19129219_ChIP-ChIP_H3396_Human	1.17496823
69	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.17128837
70	NCOR_22424771_ChIP-Seq_293T_Human	1.17008731
71	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.16867635
72	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.16560493
73	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.15741427
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13989222
75	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08606236
76	CTCF_27219007_Chip-Seq_Bcells_Human	1.07618538
77	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.06319406
78	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.06319406
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06050855
80	REST_21632747_ChIP-Seq_MESCs_Mouse	1.05609759
81	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.03277905
82	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.03110858
83	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02767283
84	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.02692500
85	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.02471607
86	STAT1_20625510_ChIP-Seq_HELA_Human	1.02401971
87	P53_21459846_ChIP-Seq_SAOS-2_Human	1.00839033
88	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.99951664
89	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.99696625
90	RNF2_27304074_Chip-Seq_NSC_Mouse	0.99073338
91	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.98680726
92	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.97713456
93	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96833952
94	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.94778622
95	SOX2_21211035_ChIP-Seq_LN229_Human	0.94225933
96	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.93947725
97	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.93552768
98	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.92185044
99	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.92145653
100	RAC3_21632823_ChIP-Seq_H3396_Human	0.91825347

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.76162660
2	MP0006292_abnormal_olfactory_placode	4.35426598
3	MP0002163_abnormal_gland_morphology	3.93331942
4	MP0003646_muscle_fatigue	3.53008212
5	MP0002837_dystrophic_cardiac_calcinosis	3.14929950
6	MP0002653_abnormal_ependyma_morphology	2.94265569
7	MP0005623_abnormal_meninges_morphology	2.66949819
8	MP0005379_endocrine/exocrine_gland_phen	2.33710242
9	MP0004145_abnormal_muscle_electrophysio	2.19996995
10	MP0002638_abnormal_pupillary_reflex	2.09054990
11	MP0003136_yellow_coat_color	1.85370151
12	MP0004142_abnormal_muscle_tone	1.73740404
13	MP0008789_abnormal_olfactory_epithelium	1.73420984
14	MP0000049_abnormal_middle_ear	1.72802622
15	MP0003122_maternal_imprinting	1.66253024
16	MP0001986_abnormal_taste_sensitivity	1.54781339
17	MP0003787_abnormal_imprinting	1.53342371
18	MP0003123_paternal_imprinting	1.53223611
19	MP0002938_white_spotting	1.50920733
20	MP0008875_abnormal_xenobiotic_pharmacok	1.49155605
21	MP0004885_abnormal_endolymph	1.47908620
22	MP0003186_abnormal_redox_activity	1.47478605
23	MP0006276_abnormal_autonomic_nervous	1.43951909
24	MP0005646_abnormal_pituitary_gland	1.42299958
25	MP0005423_abnormal_somatic_nervous	1.42122374
26	MP0000750_abnormal_muscle_regeneration	1.38393435
27	MP0005499_abnormal_olfactory_system	1.38301121
28	MP0005394_taste/olfaction_phenotype	1.38301121
29	MP0008872_abnormal_physiological_respon	1.35565973
30	MP0004130_abnormal_muscle_cell	1.35472204
31	MP0002095_abnormal_skin_pigmentation	1.32125985
32	MP0005551_abnormal_eye_electrophysiolog	1.31536433
33	MP0000678_abnormal_parathyroid_gland	1.29318345
34	MP0002160_abnormal_reproductive_system	1.25858377
35	MP0008775_abnormal_heart_ventricle	1.24286467
36	MP0003878_abnormal_ear_physiology	1.22285096
37	MP0005377_hearing/vestibular/ear_phenot	1.22285096
38	MP0009046_muscle_twitch	1.21306441
39	MP0002234_abnormal_pharynx_morphology	1.21080452
40	MP0003121_genomic_imprinting	1.20819681
41	MP0001968_abnormal_touch/_nociception	1.18914256
42	MP0005389_reproductive_system_phenotype	1.15615440
43	MP0005671_abnormal_response_to	1.15295524
44	MP0000631_abnormal_neuroendocrine_gland	1.13026967
45	MP0002272_abnormal_nervous_system	1.12703105
46	MP0001348_abnormal_lacrimal_gland	1.06853128
47	MP0009745_abnormal_behavioral_response	1.06705059
48	MP0001905_abnormal_dopamine_level	1.04840985
49	MP0003011_delayed_dark_adaptation	1.04273255
50	MP0002277_abnormal_respiratory_mucosa	1.02610861
51	MP0002736_abnormal_nociception_after	1.00122031
52	MP0003786_premature_aging	0.99668177
53	MP0001919_abnormal_reproductive_system	0.96479302
54	MP0004858_abnormal_nervous_system	0.96182073
55	MP0004147_increased_porphyrin_level	0.95204915
56	MP0008877_abnormal_DNA_methylation	0.94960579
57	MP0002733_abnormal_thermal_nociception	0.93509554
58	MP0000372_irregular_coat_pigmentation	0.91400005
59	MP0006036_abnormal_mitochondrial_physio	0.89622258
60	MP0005195_abnormal_posterior_eye	0.88258131
61	MP0001485_abnormal_pinna_reflex	0.84648905
62	MP0001970_abnormal_pain_threshold	0.83891043
63	MP0005645_abnormal_hypothalamus_physiol	0.80972244
64	MP0003806_abnormal_nucleotide_metabolis	0.80262808
65	MP0009250_abnormal_appendicular_skeleto	0.78496944
66	MP0002752_abnormal_somatic_nervous	0.77268033
67	MP0003879_abnormal_hair_cell	0.77082002
68	MP0009765_abnormal_xenobiotic_induced	0.76407643
69	MP0001293_anophthalmia	0.75876076
70	MP0009764_decreased_sensitivity_to	0.75754143
71	MP0000026_abnormal_inner_ear	0.75115455
72	MP0002249_abnormal_larynx_morphology	0.74644153
73	MP0001188_hyperpigmentation	0.74332918
74	MP0002822_catalepsy	0.73914459
75	MP0005360_urolithiasis	0.73406532
76	MP0003880_abnormal_central_pattern	0.73233683
77	MP0004133_heterotaxia	0.72960917
78	MP0002735_abnormal_chemical_nociception	0.72107509
79	MP0006072_abnormal_retinal_apoptosis	0.71375391
80	MP0000566_synostosis	0.71136590
81	MP0001663_abnormal_digestive_system	0.70843489
82	MP0004742_abnormal_vestibular_system	0.70402239
83	MP0002184_abnormal_innervation	0.69725893
84	MP0001756_abnormal_urination	0.69110599
85	MP0005332_abnormal_amino_acid	0.68683346
86	MP0002876_abnormal_thyroid_physiology	0.68110779
87	MP0002102_abnormal_ear_morphology	0.67907382
88	MP0001764_abnormal_homeostasis	0.66639992
89	MP0001529_abnormal_vocalization	0.66632744
90	MP0002067_abnormal_sensory_capabilities	0.65908383
91	MP0003567_abnormal_fetal_cardiomyocyte	0.65126396
92	MP0003195_calcinosis	0.64664389
93	MP0000955_abnormal_spinal_cord	0.63828761
94	MP0002138_abnormal_hepatobiliary_system	0.63591295
95	MP0002064_seizures	0.62604993
96	MP0001440_abnormal_grooming_behavior	0.61506686
97	MP0002572_abnormal_emotion/affect_behav	0.58042387
98	MP0001286_abnormal_eye_development	0.56791272
99	MP0003938_abnormal_ear_development	0.56741803
100	MP0003279_aneurysm	0.56017195

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.39584361
2	Abnormality of cells of the erythroid lineage (HP:0012130)	5.35241079
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.89360642
4	Abnormal number of erythroid precursors (HP:0012131)	4.79894846
5	Acute encephalopathy (HP:0006846)	4.48828039
6	Progressive macrocephaly (HP:0004481)	4.43876124
7	Mitochondrial inheritance (HP:0001427)	4.38522825
8	Pallor (HP:0000980)	4.35368336
9	Reticulocytopenia (HP:0001896)	4.31046820
10	Type II lissencephaly (HP:0007260)	4.04365116
11	Macrocytic anemia (HP:0001972)	3.90505035
12	Increased CSF lactate (HP:0002490)	3.79359934
13	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.61625397
14	Hypoplasia of the pons (HP:0012110)	3.55241480
15	Increased hepatocellular lipid droplets (HP:0006565)	3.52842120
16	3-Methylglutaconic aciduria (HP:0003535)	3.51361877
17	Cerebellar dysplasia (HP:0007033)	3.48626064
18	Hepatocellular necrosis (HP:0001404)	3.31220375
19	Renal Fanconi syndrome (HP:0001994)	3.31169514
20	Lipid accumulation in hepatocytes (HP:0006561)	3.29027664
21	Absent/shortened dynein arms (HP:0200106)	3.24958171
22	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.24958171
23	Chronic hepatic failure (HP:0100626)	3.17787398
24	Abnormality of the pons (HP:0007361)	3.17169357
25	Retinal dysplasia (HP:0007973)	3.11760244
26	Cerebral edema (HP:0002181)	3.11049709
27	Increased intramyocellular lipid droplets (HP:0012240)	3.00254723
28	Retinal atrophy (HP:0001105)	2.99081167
29	Hepatic necrosis (HP:0002605)	2.94658094
30	Pancreatic fibrosis (HP:0100732)	2.89025174
31	Molar tooth sign on MRI (HP:0002419)	2.78781880
32	Abnormality of midbrain morphology (HP:0002418)	2.78781880
33	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.76226638
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.75482128
35	Pendular nystagmus (HP:0012043)	2.73143277
36	Optic disc pallor (HP:0000543)	2.71891240
37	Pancreatic cysts (HP:0001737)	2.70902215
38	Increased muscle lipid content (HP:0009058)	2.56541835
39	Septo-optic dysplasia (HP:0100842)	2.53759788
40	Abolished electroretinogram (ERG) (HP:0000550)	2.50727580
41	Dyskinesia (HP:0100660)	2.49762512
42	True hermaphroditism (HP:0010459)	2.45251639
43	Congenital stationary night blindness (HP:0007642)	2.45232293
44	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.44416243
45	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.44416243
46	Abnormal hemoglobin (HP:0011902)	2.44407400
47	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.38110975
48	Myokymia (HP:0002411)	2.36376872
49	Exertional dyspnea (HP:0002875)	2.35127062
50	Respiratory failure (HP:0002878)	2.34556177
51	Sclerocornea (HP:0000647)	2.32438981
52	Leukodystrophy (HP:0002415)	2.28980143
53	Increased serum lactate (HP:0002151)	2.27190948
54	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.25508106
55	Abnormality of renal resorption (HP:0011038)	2.23714775
56	Abnormal respiratory epithelium morphology (HP:0012253)	2.21170963
57	Abnormal respiratory motile cilium morphology (HP:0005938)	2.21170963
58	Lactic acidosis (HP:0003128)	2.20588470
59	Polydipsia (HP:0001959)	2.18299072
60	Abnormal drinking behavior (HP:0030082)	2.18299072
61	Anencephaly (HP:0002323)	2.14821785
62	Decreased central vision (HP:0007663)	2.13717914
63	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.13347880
64	Cystic liver disease (HP:0006706)	2.09838951
65	Respiratory difficulties (HP:0002880)	2.07734132
66	Abnormal ciliary motility (HP:0012262)	2.06919842
67	Absent thumb (HP:0009777)	2.06281158
68	Hyperglycinemia (HP:0002154)	2.05514224
69	Hyperphosphaturia (HP:0003109)	2.05416707
70	Abnormal respiratory motile cilium physiology (HP:0012261)	2.05358879
71	Severe muscular hypotonia (HP:0006829)	2.03583921
72	Tubular atrophy (HP:0000092)	1.98020519
73	Exercise intolerance (HP:0003546)	1.97993540
74	Asplenia (HP:0001746)	1.93216352
75	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.90287494
76	Microretrognathia (HP:0000308)	1.88692388
77	Type 2 muscle fiber atrophy (HP:0003554)	1.87193181
78	Hyperthyroidism (HP:0000836)	1.85552261
79	Depressed nasal ridge (HP:0000457)	1.84702590
80	Partial duplication of thumb phalanx (HP:0009944)	1.83562691
81	Lissencephaly (HP:0001339)	1.83019402
82	Abnormality of urine glucose concentration (HP:0011016)	1.82532297
83	Glycosuria (HP:0003076)	1.82532297
84	Polyuria (HP:0000103)	1.80323141
85	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.79947415
86	Holoprosencephaly (HP:0001360)	1.79350857
87	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.78231570
88	Abnormality of alanine metabolism (HP:0010916)	1.78204727
89	Hyperalaninemia (HP:0003348)	1.78204727
90	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.78204727
91	Muscle fiber atrophy (HP:0100295)	1.77812986
92	Abnormality of the diencephalon (HP:0010662)	1.77366410
93	Nephronophthisis (HP:0000090)	1.76275324
94	Hypoplasia of the radius (HP:0002984)	1.75382950
95	Medial flaring of the eyebrow (HP:0010747)	1.74059110
96	CNS demyelination (HP:0007305)	1.73793038
97	Poor suck (HP:0002033)	1.72370983
98	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.71335416
99	Lethargy (HP:0001254)	1.70096839
100	X-linked dominant inheritance (HP:0001423)	1.69420500

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PASK	4.62662094
2	NME2	4.21763925
3	LIMK1	2.95819521
4	CAMKK1	2.81610424
5	TXK	2.74600815
6	LRRK2	2.70263027
7	MAP4K1	2.67542195
8	ADRBK2	2.19963492
9	MARK3	2.17633854
10	DYRK2	2.15468004
11	STK16	2.06342844
12	CAMKK2	1.95902092
13	MAP3K13	1.93431617
14	WNK4	1.93105607
15	ZAK	1.90658800
16	GRK1	1.77759458
17	BCKDK	1.76343258
18	STK11	1.56935171
19	TIE1	1.49773972
20	RIPK4	1.44015685
21	MAP4K2	1.34516166
22	STK10	1.32035232
23	WNK3	1.29232564
24	CDK19	1.25103142
25	TLK1	1.23078547
26	KDR	1.21421002
27	PRKCG	1.20580036
28	PDK2	1.19320504
29	NUAK1	1.16084559
30	BMPR1B	1.14879072
31	PIK3CA	1.12879777
32	RPS6KA5	1.11483691
33	ABL2	1.09396869
34	PINK1	1.09198141
35	BRSK1	1.08448858
36	INSRR	1.07906743
37	PIM1	1.07389877
38	PLK4	1.07277123
39	FRK	1.06602571
40	PRKCQ	1.04493829
41	MAP2K7	0.97165907
42	MAP3K11	0.97156137
43	ADRBK1	0.95394815
44	CSNK2A2	0.90471777
45	CDK8	0.89890700
46	OBSCN	0.87616774
47	AURKA	0.85827490
48	CAMK1	0.84490060
49	EPHB2	0.83709932
50	IKBKB	0.82582323
51	MUSK	0.81963428
52	BTK	0.81038157
53	TEC	0.77181451
54	NTRK2	0.76548472
55	MAPK13	0.69999088
56	CDC42BPA	0.69061064
57	PRKACA	0.68959187
58	PRKCH	0.68809997
59	PIM2	0.67937429
60	CDC7	0.67430846
61	CSNK2A1	0.66314917
62	SYK	0.64112189
63	PKN1	0.62852927
64	ILK	0.62796245
65	LCK	0.62731336
66	NEK1	0.58925702
67	ITK	0.58580204
68	PAK1	0.58112251
69	NME1	0.57598227
70	MAPK15	0.56676126
71	DYRK1A	0.55999467
72	DYRK1B	0.53031038
73	OXSR1	0.52870300
74	SGK494	0.52617077
75	SGK223	0.52617077
76	PRKCA	0.51989965
77	PRKCD	0.51665292
78	EPHA4	0.50220454
79	CSNK1A1	0.47577405
80	TYRO3	0.46292093
81	LYN	0.44898120
82	NEK2	0.44835079
83	SGK1	0.43393694
84	PRKCZ	0.42549187
85	TGFBR1	0.40689043
86	BRAF	0.39499698
87	PLK1	0.37922061
88	GRK7	0.37187430
89	DAPK3	0.36905241
90	CASK	0.34886404
91	PRKACG	0.32982833
92	SIK2	0.31270290
93	ATR	0.30855813
94	CLK1	0.30536761
95	PTK2B	0.30249706
96	AURKB	0.30077529
97	JAK3	0.29506613
98	CSNK1E	0.28767517
99	PHKG1	0.28431349
100	PHKG2	0.28431349

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	8.33462118
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.70001281
3	Parkinsons disease_Homo sapiens_hsa05012	3.89385502
4	Sulfur relay system_Homo sapiens_hsa04122	3.54677881
5	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.79729655
6	Huntingtons disease_Homo sapiens_hsa05016	2.78562243
7	Alzheimers disease_Homo sapiens_hsa05010	2.75144274
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.54300759
9	RNA polymerase_Homo sapiens_hsa03020	2.27633454
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.04305079
11	Asthma_Homo sapiens_hsa05310	1.77850155
12	Pyrimidine metabolism_Homo sapiens_hsa00240	1.71263122
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.67385504
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.41906175
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.37375082
16	Allograft rejection_Homo sapiens_hsa05330	1.28482089
17	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.25795764
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.24807072
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.22326077
20	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.21235350
21	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.18483662
22	Proteasome_Homo sapiens_hsa03050	1.16237866
23	RNA degradation_Homo sapiens_hsa03018	1.06004622
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.05316875
25	Phototransduction_Homo sapiens_hsa04744	1.04373533
26	DNA replication_Homo sapiens_hsa03030	1.00983015
27	Type I diabetes mellitus_Homo sapiens_hsa04940	0.99415148
28	Protein export_Homo sapiens_hsa03060	0.98014344
29	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.96590769
30	Nitrogen metabolism_Homo sapiens_hsa00910	0.95281839
31	Primary immunodeficiency_Homo sapiens_hsa05340	0.93930781
32	Sulfur metabolism_Homo sapiens_hsa00920	0.92573249
33	Fat digestion and absorption_Homo sapiens_hsa04975	0.90809618
34	One carbon pool by folate_Homo sapiens_hsa00670	0.89061164
35	Homologous recombination_Homo sapiens_hsa03440	0.88015159
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84462859
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.79570350
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78586863
39	Purine metabolism_Homo sapiens_hsa00230	0.76632809
40	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.76324746
41	Fanconi anemia pathway_Homo sapiens_hsa03460	0.75662442
42	Metabolic pathways_Homo sapiens_hsa01100	0.75337896
43	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.74847433
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74415251
45	Olfactory transduction_Homo sapiens_hsa04740	0.73538185
46	Nicotine addiction_Homo sapiens_hsa05033	0.70081694
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67366391
48	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.66825494
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66036263
50	Tyrosine metabolism_Homo sapiens_hsa00350	0.65588919
51	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.63201455
52	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.63140756
53	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62319518
54	Peroxisome_Homo sapiens_hsa04146	0.60106168
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.59614111
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.58630296
57	Rheumatoid arthritis_Homo sapiens_hsa05323	0.56959962
58	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.55111459
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53172382
60	Retinol metabolism_Homo sapiens_hsa00830	0.52957436
61	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.50373448
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50109549
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.49339389
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48798490
65	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.48406047
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.48347902
67	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48244206
68	Butanoate metabolism_Homo sapiens_hsa00650	0.47553397
69	Nucleotide excision repair_Homo sapiens_hsa03420	0.47442585
70	Regulation of autophagy_Homo sapiens_hsa04140	0.46691233
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46314758
72	Insulin secretion_Homo sapiens_hsa04911	0.45947096
73	Caffeine metabolism_Homo sapiens_hsa00232	0.45920371
74	Base excision repair_Homo sapiens_hsa03410	0.43900688
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.43753013
76	Antigen processing and presentation_Homo sapiens_hsa04612	0.43290523
77	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.42995826
78	Ether lipid metabolism_Homo sapiens_hsa00565	0.40901649
79	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.40315354
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39778216
81	Morphine addiction_Homo sapiens_hsa05032	0.39031192
82	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.38381969
83	Folate biosynthesis_Homo sapiens_hsa00790	0.36232151
84	Mismatch repair_Homo sapiens_hsa03430	0.35420427
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34611905
86	Basal transcription factors_Homo sapiens_hsa03022	0.33236946
87	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.31935501
88	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.31716565
89	Spliceosome_Homo sapiens_hsa03040	0.30124110
90	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.28438892
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.27111585
92	Fatty acid degradation_Homo sapiens_hsa00071	0.22605382
93	Glutathione metabolism_Homo sapiens_hsa00480	0.22507648
94	RNA transport_Homo sapiens_hsa03013	0.20971217
95	Arginine and proline metabolism_Homo sapiens_hsa00330	0.20620545
96	Serotonergic synapse_Homo sapiens_hsa04726	0.20299150
97	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.17968937
98	Phenylalanine metabolism_Homo sapiens_hsa00360	0.17816446
99	Propanoate metabolism_Homo sapiens_hsa00640	0.16341738
100	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.16203638

RPL36AP13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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