RPL36AP15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)6.89480193
2DNA deamination (GO:0045006)6.84163863
3interferon-gamma production (GO:0032609)6.41639055
4GDP-mannose metabolic process (GO:0019673)6.25261371
5positive regulation of defense response to virus by host (GO:0002230)6.09927875
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.12301313
7leukocyte aggregation (GO:0070486)4.87006418
8nucleoside transmembrane transport (GO:1901642)4.66406137
9mannose metabolic process (GO:0006013)4.50375808
10cytidine deamination (GO:0009972)4.26146217
11cytidine metabolic process (GO:0046087)4.26146217
12cytidine catabolic process (GO:0006216)4.26146217
13negative regulation of mast cell activation (GO:0033004)4.09111368
14endoderm formation (GO:0001706)3.99424817
15pyrimidine ribonucleoside catabolic process (GO:0046133)3.88376885
16exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.88020311
17regulation of defense response to virus by host (GO:0050691)3.83046971
18nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.81875633
19positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.65716930
20cellular response to interleukin-15 (GO:0071350)3.65557881
21reproduction (GO:0000003)3.60672798
22positive regulation of T cell mediated cytotoxicity (GO:0001916)3.56524373
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.56297090
24activation of MAPKKK activity (GO:0000185)3.50376526
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.41634582
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.41634582
27regulation of T cell mediated cytotoxicity (GO:0001914)3.37315809
28regulation of memory T cell differentiation (GO:0043380)3.36996766
29nucleoside transport (GO:0015858)3.31059285
30positive regulation of T-helper 1 type immune response (GO:0002827)3.25934587
31mast cell activation (GO:0045576)3.25441409
32RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.22185367
33nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)3.20569900
34regulation of regulatory T cell differentiation (GO:0045589)3.20280443
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.14429426
36meiotic chromosome segregation (GO:0045132)3.12137869
37lateral ventricle development (GO:0021670)3.10858683
38rRNA catabolic process (GO:0016075)3.07845440
39maturation of 5.8S rRNA (GO:0000460)3.07177496
40peroxisome fission (GO:0016559)3.02175255
41positive regulation of T cell cytokine production (GO:0002726)3.02066786
42transcription from mitochondrial promoter (GO:0006390)3.01377275
43positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.96110134
44regulation of activation of Janus kinase activity (GO:0010533)2.95506617
45negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.93748363
46epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.87041286
47regulation of T-helper 1 type immune response (GO:0002825)2.86595806
48piRNA metabolic process (GO:0034587)2.85516791
49cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.84497788
50positive regulation of T cell mediated immunity (GO:0002711)2.84110114
51regulation of leukocyte mediated cytotoxicity (GO:0001910)2.84022432
52cellular defense response (GO:0006968)2.83984736
53negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.82263541
54negative regulation of cell killing (GO:0031342)2.82263541
55regulation of B cell receptor signaling pathway (GO:0050855)2.77197422
56pantothenate metabolic process (GO:0015939)2.77068175
57positive regulation of cell killing (GO:0031343)2.75754236
58negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.73288544
59regulation of germinal center formation (GO:0002634)2.72866563
60protein deneddylation (GO:0000338)2.72818985
61negative T cell selection (GO:0043383)2.71495501
62cofactor transport (GO:0051181)2.69477558
63response to interleukin-15 (GO:0070672)2.69281517
64mast cell degranulation (GO:0043303)2.69140698
65mast cell activation involved in immune response (GO:0002279)2.69140698
66forebrain morphogenesis (GO:0048853)2.68504143
67response to interferon-beta (GO:0035456)2.67412895
68regulation of cell killing (GO:0031341)2.63745989
69cellular ketone body metabolic process (GO:0046950)2.62238805
70maturation of SSU-rRNA (GO:0030490)2.61904013
71regulation of chronic inflammatory response (GO:0002676)2.61807756
72positive regulation of protein homooligomerization (GO:0032464)2.60338590
73coenzyme A biosynthetic process (GO:0015937)2.59798521
74somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.57881416
75somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.57881416
76isotype switching (GO:0045190)2.57881416
77response to pheromone (GO:0019236)2.57733377
78rRNA transcription (GO:0009303)2.56331097
79positive regulation of icosanoid secretion (GO:0032305)2.55730869
80positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.55496548
81reciprocal meiotic recombination (GO:0007131)2.55427985
82reciprocal DNA recombination (GO:0035825)2.55427985
83glycoprotein catabolic process (GO:0006516)2.54749677
84positive regulation of T cell differentiation in thymus (GO:0033089)2.54735174
85protein polyglutamylation (GO:0018095)2.53265215
86water-soluble vitamin biosynthetic process (GO:0042364)2.53107070
87positive regulation of signal transduction by p53 class mediator (GO:1901798)2.52484649
88positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.52409079
89negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.51866623
90negative regulation of T-helper cell differentiation (GO:0045623)2.51866623
91positive regulation of fatty acid transport (GO:2000193)2.50301011
92regulation of T cell mediated immunity (GO:0002709)2.48752513
93positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.46723150
94sleep (GO:0030431)2.46661665
95negative regulation of interleukin-1 beta production (GO:0032691)2.45736850
96modified amino acid transport (GO:0072337)2.45473022
97positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.45322299
98positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.44463371
99regulation of mitochondrial membrane potential (GO:0051881)2.44447336
100L-fucose metabolic process (GO:0042354)2.43803050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.80162108
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.22177564
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.98561449
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.56943233
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.32174782
6NOTCH1_21737748_ChIP-Seq_TLL_Human3.18762661
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.91624888
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.91048506
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.88453203
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.74379046
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.39818172
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33390386
13RUNX_20019798_ChIP-Seq_JUKART_Human2.26987809
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.26665298
15VDR_22108803_ChIP-Seq_LS180_Human2.18489084
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.13212086
17ZNF274_21170338_ChIP-Seq_K562_Hela2.05284193
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01911660
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.98174844
20GATA3_26560356_Chip-Seq_TH2_Human1.97477733
21IRF8_21731497_ChIP-ChIP_J774_Mouse1.89541442
22VDR_23849224_ChIP-Seq_CD4+_Human1.89274263
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.84662614
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.81733439
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80732644
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78077454
27TP53_22573176_ChIP-Seq_HFKS_Human1.76947996
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68017977
29FOXP3_21729870_ChIP-Seq_TREG_Human1.66216821
30MYB_26560356_Chip-Seq_TH2_Human1.64546761
31VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.61310107
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.58811232
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55238169
34AR_20517297_ChIP-Seq_VCAP_Human1.53463347
35GATA3_27048872_Chip-Seq_THYMUS_Human1.51589782
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51305766
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49121764
38GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.48672377
39RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.47159566
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.45916497
41FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45916497
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.45872940
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44843094
44GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.42618717
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38404392
46TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.36944653
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36183984
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35779817
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34014075
50FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33373780
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33099429
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26379912
53ELK1_19687146_ChIP-ChIP_HELA_Human1.23630149
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.21671906
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21160133
56EWS_26573619_Chip-Seq_HEK293_Human1.21085702
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20952551
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17149248
59GATA6_21074721_ChIP-Seq_CACO-2_Human1.16985877
60IGF1R_20145208_ChIP-Seq_DFB_Human1.16720113
61NANOG_20526341_ChIP-Seq_ESCs_Human1.14845839
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.14381681
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.14168471
64EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.13885250
65NCOR_22424771_ChIP-Seq_293T_Human1.13839795
66GATA3_26560356_Chip-Seq_TH1_Human1.13243566
67RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.13212796
68TAF2_19829295_ChIP-Seq_ESCs_Human1.12837765
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12224454
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10934321
71MYC_18940864_ChIP-ChIP_HL60_Human1.10869533
72RBPJ_21746931_ChIP-Seq_IB4_Human1.09799852
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08434514
74FOXH1_21741376_ChIP-Seq_ESCs_Human1.08125287
75STAT1_20625510_ChIP-Seq_HELA_Human1.08014738
76FOXH1_21741376_ChIP-Seq_EPCs_Human1.07096281
77SPI1_23547873_ChIP-Seq_NB4_Human1.06657331
78RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06179841
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.04885820
80SOX2_19829295_ChIP-Seq_ESCs_Human1.02865157
81NANOG_19829295_ChIP-Seq_ESCs_Human1.02865157
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02322853
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.01891942
84HOXB7_26014856_ChIP-Seq_BT474_Human1.01680876
85MYC_19829295_ChIP-Seq_ESCs_Human1.01430164
86CBP_20019798_ChIP-Seq_JUKART_Human1.01088014
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01088014
88PHF8_20622853_ChIP-Seq_HELA_Human1.00898599
89E2F1_20622854_ChIP-Seq_HELA_Human0.99688967
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98064354
91ETV1_20927104_ChIP-Seq_GIST48_Human0.97889809
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96916721
93CRX_20693478_ChIP-Seq_RETINA_Mouse0.96745488
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96043212
95P300_19829295_ChIP-Seq_ESCs_Human0.95921493
96PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.95268079
97POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93658105
98CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92824506
99SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92075376
100VDR_24787735_ChIP-Seq_THP-1_Human0.91402763

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.84396542
2MP0002638_abnormal_pupillary_reflex3.79934218
3MP0009785_altered_susceptibility_to2.84758928
4MP0006072_abnormal_retinal_apoptosis2.78815560
5MP0005623_abnormal_meninges_morphology2.74738041
6MP0001835_abnormal_antigen_presentation2.74615610
7MP0003436_decreased_susceptibility_to2.63393641
8MP0005387_immune_system_phenotype2.54303964
9MP0001790_abnormal_immune_system2.54303964
10MP0005000_abnormal_immune_tolerance2.43873935
11MP0003763_abnormal_thymus_physiology2.42396915
12MP0009379_abnormal_foot_pigmentation2.39868044
13MP0001986_abnormal_taste_sensitivity2.38940605
14MP0001800_abnormal_humoral_immune2.34747477
15MP0003724_increased_susceptibility_to2.29547770
16MP0003195_calcinosis2.26927459
17MP0002148_abnormal_hypersensitivity_rea2.26876442
18MP0000685_abnormal_immune_system2.26236092
19MP0009764_decreased_sensitivity_to2.22566137
20MP0002723_abnormal_immune_serum2.06950735
21MP0003646_muscle_fatigue2.06401035
22MP0004885_abnormal_endolymph1.94517109
23MP0002837_dystrophic_cardiac_calcinosis1.82426879
24MP0001873_stomach_inflammation1.80658110
25MP0002452_abnormal_antigen_presenting1.80125082
26MP0002420_abnormal_adaptive_immunity1.79305020
27MP0001819_abnormal_immune_cell1.79047512
28MP0009384_cardiac_valve_regurgitation1.75577314
29MP0005025_abnormal_response_to1.66833800
30MP0001727_abnormal_embryo_implantation1.63367632
31MP0004043_abnormal_pH_regulation1.61949722
32MP0005551_abnormal_eye_electrophysiolog1.55838788
33MP0008775_abnormal_heart_ventricle1.54845795
34MP0009333_abnormal_splenocyte_physiolog1.51672646
35MP0006082_CNS_inflammation1.51352824
36MP0001501_abnormal_sleep_pattern1.50730678
37MP0002234_abnormal_pharynx_morphology1.47579105
38MP0010155_abnormal_intestine_physiology1.47530044
39MP0002102_abnormal_ear_morphology1.47222325
40MP0005645_abnormal_hypothalamus_physiol1.46966608
41MP0008877_abnormal_DNA_methylation1.45696364
42MP0005075_abnormal_melanosome_morpholog1.44832745
43MP0004947_skin_inflammation1.43963471
44MP0003890_abnormal_embryonic-extraembry1.43894370
45MP0008058_abnormal_DNA_repair1.37331430
46MP0003866_abnormal_defecation1.36580449
47MP0000013_abnormal_adipose_tissue1.29215363
48MP0005253_abnormal_eye_physiology1.28773202
49MP0008875_abnormal_xenobiotic_pharmacok1.25859528
50MP0000689_abnormal_spleen_morphology1.25702558
51MP0000750_abnormal_muscle_regeneration1.25247563
52MP0002876_abnormal_thyroid_physiology1.24660663
53MP0002398_abnormal_bone_marrow1.24031918
54MP0001845_abnormal_inflammatory_respons1.23072510
55MP0000716_abnormal_immune_system1.19995086
56MP0002405_respiratory_system_inflammati1.19069722
57MP0005389_reproductive_system_phenotype1.17488013
58MP0002166_altered_tumor_susceptibility1.16018847
59MP0003786_premature_aging1.15828752
60MP0002419_abnormal_innate_immunity1.15556250
61MP0001533_abnormal_skeleton_physiology1.14805785
62MP0000858_altered_metastatic_potential1.13503181
63MP0008872_abnormal_physiological_respon1.09366022
64MP0002938_white_spotting1.08262341
65MP0006292_abnormal_olfactory_placode1.07994464
66MP0005464_abnormal_platelet_physiology1.07931418
67MP0004133_heterotaxia1.05518747
68MP0005377_hearing/vestibular/ear_phenot1.04780509
69MP0003878_abnormal_ear_physiology1.04780509
70MP0004142_abnormal_muscle_tone1.03935716
71MP0003045_fibrosis1.02011560
72MP0002722_abnormal_immune_system1.01221651
73MP0000372_irregular_coat_pigmentation0.99348670
74MP0002160_abnormal_reproductive_system0.97244665
75MP0002006_tumorigenesis0.95169886
76MP0005084_abnormal_gallbladder_morpholo0.94894498
77MP0008995_early_reproductive_senescence0.94163805
78MP0008469_abnormal_protein_level0.93688829
79MP0002429_abnormal_blood_cell0.93373177
80MP0000703_abnormal_thymus_morphology0.91153032
81MP0003950_abnormal_plasma_membrane0.90285941
82MP0000465_gastrointestinal_hemorrhage0.88514925
83MP0005174_abnormal_tail_pigmentation0.82590455
84MP0002019_abnormal_tumor_incidence0.80371585
85MP0001853_heart_inflammation0.78418521
86MP0002933_joint_inflammation0.77807348
87MP0000343_altered_response_to0.77583429
88MP0001542_abnormal_bone_strength0.77489965
89MP0005410_abnormal_fertilization0.76759390
90MP0005646_abnormal_pituitary_gland0.75840692
91MP0002138_abnormal_hepatobiliary_system0.72935129
92MP0005195_abnormal_posterior_eye0.70307002
93MP0006054_spinal_hemorrhage0.67911911
94MP0001765_abnormal_ion_homeostasis0.67228170
95MP0002277_abnormal_respiratory_mucosa0.66557031
96MP0001119_abnormal_female_reproductive0.62909627
97MP0003252_abnormal_bile_duct0.62768004
98MP0002736_abnormal_nociception_after0.62735654
99MP0004742_abnormal_vestibular_system0.62375481
100MP0001919_abnormal_reproductive_system0.62269539

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the pons (HP:0012110)5.97448360
2Abnormality of the pons (HP:0007361)5.78473912
3Elevated erythrocyte sedimentation rate (HP:0003565)5.52703554
4Cerebellar dysplasia (HP:0007033)5.00239093
5Retinal atrophy (HP:0001105)4.83171688
6Type II lissencephaly (HP:0007260)4.77033073
7IgG deficiency (HP:0004315)4.17913337
8Methylmalonic acidemia (HP:0002912)4.17192101
9Decreased electroretinogram (ERG) amplitude (HP:0000654)4.04420951
10Orchitis (HP:0100796)4.00737698
11Retrobulbar optic neuritis (HP:0100654)3.86110466
12Optic neuritis (HP:0100653)3.86110466
13Abolished electroretinogram (ERG) (HP:0000550)3.83981709
14Global brain atrophy (HP:0002283)3.81321740
15Myositis (HP:0100614)3.80747645
16Buphthalmos (HP:0000557)3.66974365
17Retinal dysplasia (HP:0007973)3.41231342
18Hypobetalipoproteinemia (HP:0003563)3.30050787
19Fatigue (HP:0012378)3.26877239
20Stomatitis (HP:0010280)3.21780335
21Methylmalonic aciduria (HP:0012120)3.10535885
22Aplasia/Hypoplasia affecting the retina (HP:0008061)2.98780122
23Abnormality of DNA repair (HP:0003254)2.96706006
24Abnormality of eosinophils (HP:0001879)2.96406749
25Dyskinesia (HP:0100660)2.87331034
26Abnormality of the phalanges of the 2nd finger (HP:0009541)2.84025942
27Eosinophilia (HP:0001880)2.79171245
28Abnormality of the vitamin B12 metabolism (HP:0004341)2.72255225
29Keratoconjunctivitis (HP:0001096)2.65731558
30Neurodegeneration (HP:0002180)2.65263790
31Abnormality of vitamin B metabolism (HP:0004340)2.56550323
32Delayed CNS myelination (HP:0002188)2.55031781
33Keratoconjunctivitis sicca (HP:0001097)2.54286218
34T lymphocytopenia (HP:0005403)2.53643475
35Congenital stationary night blindness (HP:0007642)2.51121629
36Hypoproteinemia (HP:0003075)2.48075352
37Severe combined immunodeficiency (HP:0004430)2.47006023
38Keratitis (HP:0000491)2.46626253
39Decreased muscle mass (HP:0003199)2.46564498
40Congenital glaucoma (HP:0001087)2.42604059
41Acanthocytosis (HP:0001927)2.41423922
42Abnormality of T cell number (HP:0011839)2.40620273
43Encephalitis (HP:0002383)2.39625932
44Leukocytosis (HP:0001974)2.36444141
45Anorexia (HP:0002039)2.35715597
46Entropion (HP:0000621)2.35115485
47Akinesia (HP:0002304)2.27103204
48Nephronophthisis (HP:0000090)2.22843629
49Severe muscular hypotonia (HP:0006829)2.22456088
50Abnormality of T cells (HP:0002843)2.20104126
51Ketoacidosis (HP:0001993)2.19082527
52Pancreatic cysts (HP:0001737)2.15790828
53Thyroiditis (HP:0100646)2.15132201
54Increased IgM level (HP:0003496)2.12653560
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10528609
56Abnormality of alanine metabolism (HP:0010916)2.10528609
57Hyperalaninemia (HP:0003348)2.10528609
58Vasculitis (HP:0002633)2.09909141
59Absent/shortened dynein arms (HP:0200106)2.08268980
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.08268980
61Hyperglycinemia (HP:0002154)2.05108341
62Granulocytopenia (HP:0001913)2.02709817
63Hemoptysis (HP:0002105)2.01789854
64Clumsiness (HP:0002312)2.00296095
65Pulmonary infiltrates (HP:0002113)1.99892991
66Recurrent bronchitis (HP:0002837)1.99020601
67Absent thumb (HP:0009777)1.98176283
68Carpal bone hypoplasia (HP:0001498)1.98015618
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.96598029
70Poor head control (HP:0002421)1.96534528
71Abnormality of the renal cortex (HP:0011035)1.95974332
72Tubulointerstitial nephritis (HP:0001970)1.95792397
73Poikiloderma (HP:0001029)1.95177859
74Abnormality of the basal ganglia (HP:0002134)1.92687855
75CNS demyelination (HP:0007305)1.91889829
76Difficulty climbing stairs (HP:0003551)1.90951879
77Abnormality of the renal medulla (HP:0100957)1.87372034
78Abnormality of midbrain morphology (HP:0002418)1.87188805
79Molar tooth sign on MRI (HP:0002419)1.87188805
80Hepatocellular necrosis (HP:0001404)1.86127488
81Generalized hypotonia (HP:0001290)1.81970444
82Brushfield spots (HP:0001088)1.81159422
83Abnormal albumin level (HP:0012116)1.79668243
84Hypoalbuminemia (HP:0003073)1.79668243
85Combined immunodeficiency (HP:0005387)1.79055533
86Long nose (HP:0003189)1.78915257
87Delayed closure of the anterior fontanelle (HP:0001476)1.75605193
88Dysphonia (HP:0001618)1.73764852
89Increased CSF lactate (HP:0002490)1.72776807
90Abnormality of B cell number (HP:0010975)1.72194909
91Gangrene (HP:0100758)1.72187663
92Tubulointerstitial abnormality (HP:0001969)1.71072048
93Brittle hair (HP:0002299)1.68485823
94Chronic hepatic failure (HP:0100626)1.67777898
95Pachygyria (HP:0001302)1.66679740
96Hepatic necrosis (HP:0002605)1.66178327
97Abnormal drinking behavior (HP:0030082)1.65699110
98Polydipsia (HP:0001959)1.65699110
99Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.64209320
100Abnormality of T cell physiology (HP:0011840)1.63388767

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.64756164
2STK103.57274643
3MARK33.39601241
4CDK193.14205688
5TLK12.69032371
6TAOK32.60630374
7MAP2K62.50100024
8FRK2.49871221
9GRK62.32527869
10EPHA32.22023474
11MAP4K22.02599280
12ADRBK21.93661732
13PIM11.93625264
14MST41.91209206
15MAP4K11.86217573
16NUAK11.74733564
17IKBKB1.67329200
18ZAK1.65360507
19MUSK1.65352936
20KIT1.48911628
21GRK11.42716365
22MAP2K21.42083466
23WNK41.41812872
24MAP3K141.38713503
25PDK21.38498056
26ZAP701.33243655
27ERN11.32169501
28LCK1.31168817
29TRIM281.26092261
30FES1.25397302
31PTK2B1.20293078
32SYK1.17022612
33IKBKE1.10699618
34NLK1.09424290
35OXSR11.04503996
36PASK1.04487042
37JAK11.02356384
38PIK3CA1.02011536
39TEC1.00719946
40STK111.00644753
41PRKCH0.97355629
42PINK10.96921645
43CAMKK20.95728903
44TESK20.95127905
45CASK0.92100911
46SIK20.88368664
47BTK0.88072745
48ITK0.87635482
49LYN0.86099498
50TIE10.82790242
51SRPK10.80077026
52TBK10.79206468
53PRKCQ0.78716590
54FLT30.76859144
55PIK3CG0.76553901
56IRAK10.69520895
57ADRBK10.67197405
58EIF2AK30.67103620
59EPHB10.66569185
60AKT20.65779873
61CHUK0.65382961
62INSRR0.61248864
63PHKG20.60426142
64PHKG10.60426142
65BCKDK0.60142924
66PRKCE0.57706487
67NEK20.57391770
68RPS6KA60.56103225
69WNK30.54811742
70MATK0.54501066
71CSF1R0.54032530
72IGF1R0.53820703
73STK390.53649458
74RPS6KA50.50656843
75VRK10.49947968
76BMPR20.49614902
77HCK0.49320549
78PRKCD0.47285265
79OBSCN0.46002782
80KDR0.45778730
81DYRK20.45446621
82RPS6KC10.44291117
83RPS6KL10.44291117
84ROCK10.40898515
85TSSK60.39864512
86PKN10.39567958
87JAK30.38162465
88GRK70.38115855
89ABL20.36543209
90TGFBR10.36062894
91ABL10.33871516
92PRKCA0.33428810
93PLK40.33137566
94PRKCI0.32133214
95DAPK20.30825033
96ATR0.30681713
97INSR0.29105924
98VRK20.29007262
99PDK10.27507521
100HIPK20.26901840

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.64507419
2Asthma_Homo sapiens_hsa053103.20148124
3Allograft rejection_Homo sapiens_hsa053303.16566736
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.06716885
5Autoimmune thyroid disease_Homo sapiens_hsa053203.04589011
6Type I diabetes mellitus_Homo sapiens_hsa049402.76970439
7Primary immunodeficiency_Homo sapiens_hsa053402.52572556
8Proteasome_Homo sapiens_hsa030502.50131073
9Antigen processing and presentation_Homo sapiens_hsa046122.47432866
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.27832604
11Ribosome_Homo sapiens_hsa030102.24010649
12Linoleic acid metabolism_Homo sapiens_hsa005912.06559793
13Sulfur metabolism_Homo sapiens_hsa009201.98875723
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.97923907
15Phototransduction_Homo sapiens_hsa047441.92836207
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91990447
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89047987
18RNA degradation_Homo sapiens_hsa030181.86254666
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.86136406
20Caffeine metabolism_Homo sapiens_hsa002321.81992717
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79514127
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.76659566
23Leishmaniasis_Homo sapiens_hsa051401.74761077
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70401267
25Regulation of autophagy_Homo sapiens_hsa041401.68450757
26Hematopoietic cell lineage_Homo sapiens_hsa046401.60754049
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.48435299
28Oxidative phosphorylation_Homo sapiens_hsa001901.43237450
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.38125170
30RNA polymerase_Homo sapiens_hsa030201.33192290
31Homologous recombination_Homo sapiens_hsa034401.28565490
32Basal transcription factors_Homo sapiens_hsa030221.27180651
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24879607
34Rheumatoid arthritis_Homo sapiens_hsa053231.24812714
35Ether lipid metabolism_Homo sapiens_hsa005651.24011786
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19530509
37Herpes simplex infection_Homo sapiens_hsa051681.09442120
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08382407
39Nitrogen metabolism_Homo sapiens_hsa009101.05224696
40Staphylococcus aureus infection_Homo sapiens_hsa051501.04264123
41Viral myocarditis_Homo sapiens_hsa054161.02074604
42Protein export_Homo sapiens_hsa030601.00255390
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93145787
44T cell receptor signaling pathway_Homo sapiens_hsa046600.92358973
45Tryptophan metabolism_Homo sapiens_hsa003800.91496510
46Fanconi anemia pathway_Homo sapiens_hsa034600.90766566
47Arachidonic acid metabolism_Homo sapiens_hsa005900.90698605
48Parkinsons disease_Homo sapiens_hsa050120.87412614
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87258531
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86508111
51Propanoate metabolism_Homo sapiens_hsa006400.82785299
52Vitamin digestion and absorption_Homo sapiens_hsa049770.79644204
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79546034
54TNF signaling pathway_Homo sapiens_hsa046680.79064883
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78882959
56Toxoplasmosis_Homo sapiens_hsa051450.78430986
57Selenocompound metabolism_Homo sapiens_hsa004500.77714567
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.70696689
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67577242
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.66666374
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63968612
62Butanoate metabolism_Homo sapiens_hsa006500.62843506
63Olfactory transduction_Homo sapiens_hsa047400.61644766
64One carbon pool by folate_Homo sapiens_hsa006700.60688768
65Systemic lupus erythematosus_Homo sapiens_hsa053220.59383613
66Measles_Homo sapiens_hsa051620.58962487
67Alzheimers disease_Homo sapiens_hsa050100.58148455
68Peroxisome_Homo sapiens_hsa041460.57966145
69Osteoclast differentiation_Homo sapiens_hsa043800.56639948
70Fat digestion and absorption_Homo sapiens_hsa049750.54736840
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54148929
72Nucleotide excision repair_Homo sapiens_hsa034200.53815169
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49271764
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48901903
75Epstein-Barr virus infection_Homo sapiens_hsa051690.48721352
76Huntingtons disease_Homo sapiens_hsa050160.46818507
77B cell receptor signaling pathway_Homo sapiens_hsa046620.44258200
78Collecting duct acid secretion_Homo sapiens_hsa049660.42828903
79Cardiac muscle contraction_Homo sapiens_hsa042600.42631662
80Chemical carcinogenesis_Homo sapiens_hsa052040.41671305
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39897560
82Pyrimidine metabolism_Homo sapiens_hsa002400.38630707
83Malaria_Homo sapiens_hsa051440.36950787
84Glycerolipid metabolism_Homo sapiens_hsa005610.34638602
85RNA transport_Homo sapiens_hsa030130.31362684
86Purine metabolism_Homo sapiens_hsa002300.30782526
87Taste transduction_Homo sapiens_hsa047420.29868133
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29708736
89Tuberculosis_Homo sapiens_hsa051520.29316178
90Fructose and mannose metabolism_Homo sapiens_hsa000510.29181593
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.28979436
92African trypanosomiasis_Homo sapiens_hsa051430.27514313
93Retinol metabolism_Homo sapiens_hsa008300.23996553
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23975854
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23759371
96Influenza A_Homo sapiens_hsa051640.22920068
97Apoptosis_Homo sapiens_hsa042100.21821813
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21716610
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.21222670
100Metabolic pathways_Homo sapiens_hsa011000.21062577

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